Best TWAS P=1.479845e-08 · Best GWAS P=2.332971e-08 conditioned to 0.2042008
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Pigh | gene expression | ENSRNOG00000010914 | 0.11 | 0.02 | enet | 17 | 0.07 | 3.4e-08 | 4.5 | 5.6 | 2.4e-08 | -0.75 | 0.49 | 0.51 | FALSE |
2 | BLA | Pigh | alternative polyA | ENSRNOT00000014775 | 0.12 | 0.04 | enet | 30 | 0.06 | 5.1e-04 | -5.3 | -5.5 | 5.0e-08 | 0.81 | 0.30 | 0.62 | FALSE |
3 | BLA | Pigh | alternative polyA | ENSRNOT00000101349 | 0.16 | 0.05 | blup | 2175 | 0.07 | 8.8e-05 | -5.3 | 5.3 | 1.5e-07 | -0.77 | 0.29 | 0.69 | FALSE |
4 | BLA | Pigh | gene expression | ENSRNOG00000010914 | 0.25 | 0.14 | enet | 114 | 0.20 | 5.3e-11 | -5.3 | 5.5 | 3.2e-08 | -0.93 | 0.09 | 0.91 | FALSE |
5 | BLA | Arg2 | gene expression | ENSRNOG00000053811 | 0.20 | 0.17 | top1 | 1 | 0.17 | 2.4e-09 | -5.3 | 5.3 | 1.5e-07 | -0.92 | 0.11 | 0.88 | FALSE |
6 | BLA | Pigh | isoform ratio | ENSRNOT00000014775 | 0.19 | 0.09 | enet | 119 | 0.13 | 2.8e-07 | -5.3 | -5.4 | 7.5e-08 | 0.84 | 0.25 | 0.75 | FALSE |
7 | BLA | Pigh | isoform ratio | ENSRNOT00000101349 | 0.18 | 0.10 | enet | 156 | 0.11 | 1.0e-06 | -5.3 | 5.6 | 1.8e-08 | -0.89 | 0.14 | 0.86 | FALSE |
8 | BLA | Arg2 | mRNA stability | ENSRNOG00000053811 | 0.15 | 0.12 | top1 | 1 | 0.12 | 5.8e-07 | -5.3 | 5.3 | 1.0e-07 | -0.97 | 0.08 | 0.86 | FALSE |
9 | Brain | Atp6v1d | mRNA stability | ENSRNOG00000009080 | 0.09 | 0.01 | blup | 1744 | 0.04 | 3.0e-04 | -5.5 | -5.5 | 4.6e-08 | 0.94 | 0.04 | 0.94 | FALSE |
10 | IL | Mpp5 | mRNA stability | ENSRNOG00000008788 | 0.65 | 0.23 | blup | 1508 | 0.29 | 1.2e-07 | -4.8 | 5.2 | 2.0e-07 | -0.91 | 0.04 | 0.96 | FALSE |
11 | Liver | Pigh | isoform ratio | ENSRNOT00000101349 | 0.03 | 0.00 | blup | 2174 | 0.00 | 9.9e-02 | -5.0 | 5.7 | 1.5e-08 | -0.88 | 0.19 | 0.57 | TRUE |
12 | NAcc | Mpp5 | mRNA stability | ENSRNOG00000008788 | 0.36 | 0.12 | enet | 9 | 0.12 | 1.1e-03 | -5.3 | 5.5 | 3.9e-08 | -0.90 | 0.06 | 0.82 | FALSE |
13 | NAcc2 | Pigh | intron excision ratio | chr6:97889566:97890560 | 0.10 | 0.07 | top1 | 1 | 0.07 | 1.7e-04 | -5.3 | -5.3 | 9.5e-08 | 0.88 | 0.08 | 0.31 | FALSE |
14 | OFC | Pigh | gene expression | ENSRNOG00000010914 | 0.28 | 0.10 | lasso | 15 | 0.11 | 1.3e-03 | -4.8 | 5.1 | 2.7e-07 | -0.94 | 0.14 | 0.71 | FALSE |
15 | PL | Pigh | gene expression | ENSRNOG00000010914 | 0.54 | 0.36 | top1 | 1 | 0.36 | 1.8e-09 | -5.5 | 5.5 | 3.7e-08 | -0.91 | 0.03 | 0.96 | FALSE |
16 | PL2 | Pigh | gene expression | ENSRNOG00000010914 | 0.45 | 0.17 | blup | 2175 | 0.24 | 2.6e-13 | -4.8 | 5.4 | 5.9e-08 | -0.85 | 0.10 | 0.90 | FALSE |
17 | PL2 | Pigh | isoform ratio | ENSRNOT00000101349 | 0.08 | 0.03 | blup | 2175 | 0.05 | 1.3e-03 | -5.3 | 5.2 | 2.1e-07 | -0.91 | 0.14 | 0.79 | FALSE |
18 | PL2 | Mpp5 | mRNA stability | ENSRNOG00000008788 | 0.67 | 0.38 | enet | 105 | 0.41 | 1.3e-23 | -5.0 | 5.2 | 2.3e-07 | -0.87 | 0.10 | 0.90 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.