Hub : Genes

Wdr95

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000000904 0.15 0.08 5.9e-03 0.01 0.03 0.01 0.02 5.5e-02 1.5e-02 1.4e-01 2.8e-02
2 BLA intron excision ratio chr12:5432510:5435603 0.08 0.07 6.3e-03 0.03 0.03 0 0.03 1.4e-02 1.1e-02 3.3e-01 8.6e-03
3 Brain alternative TSS ENSRNOT00000001203 0.03 0.02 1.4e-03 0.03 0.02 0.02 0.02 1.1e-03 2.5e-03 6.0e-03 4.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.93.03.2-1.8-1.71.7
BMI without tail1.02.02.2-1.31.4-1.5
Body weight4.518.948.7-7.0-1.92.1
Epididymis fat weight2.25.28.3-0.6-2.62.9
Glucose0.30.50.90.1-1.00.8
Heart weight1.52.12.9-1.71.4-1.2
Left kidney weight2.98.221.8-4.7-1.11.3
Right kidney weight4.011.427.3-5.2-1.62.0
Tail length2.68.012.2-3.52.5-2.4
Length with tail3.914.142.3-6.5-0.20.2
Length without tail6.714.721.4-4.6-3.33.4
Liver weight, left1.72.74.4-2.1-1.41.3
Liver weight, right2.84.613.1-3.6-0.50.7
Parametrial fat weight0.30.51.6-1.3-0.10.1
Retroperitoneal fat weight2.89.113.90.3-3.63.7
Intraocular pressure0.50.71.3-0.1-0.81.1
Extensor digitorum longus weight0.83.16.1-2.5-1.31.1
Soleus weight0.51.52.0-1.4-1.20.9
Tibialis anterior weight1.34.513.4-3.7-0.1-0.0
Tibia length1.33.69.3-3.0-0.70.9
Number of licking bursts1.82.14.6-2.11.0-1.0
Food consumed during 24 hour testing period1.21.52.20.61.5-1.4
Times rat made contact with spout1.82.02.1-1.51.4-1.4
Mean time between licks in bursts0.20.30.40.50.7-0.6
Mean num. licks in bursts0.30.40.91.00.3-0.3
Std. dev. time between licks in bursts0.00.00.00.10.0-0.2
Water consumed over 24 hours1.51.82.5-1.61.2-1.1
Indifference point 0 sec0.81.31.8-0.7-1.41.3
Indifference point AUC0.40.40.9-1.00.4-0.4
Indifference point function ln k0.20.20.5-0.7-0.30.4
Indifference point function log k0.20.20.5-0.7-0.30.4
Delay discounting total patch changes 0 sec0.71.11.7-0.6-1.31.2
Delay discounting total patch changes 12 sec1.11.52.3-0.5-1.41.5
Delay discounting total patch changes 18 sec0.30.40.60.2-0.80.7
Delay discounting total patch changes 24 sec0.00.10.10.0-0.40.2
Delay discounting total patch changes 6 sec0.00.10.2-0.1-0.40.3
Delay discounting time to switch 0 sec1.11.64.42.1-0.50.5
Delay discounting water rate 0 sec1.01.64.9-2.2-0.00.1
Delay discounting water rate 12 sec0.91.33.6-1.90.4-0.5
Delay discounting water rate 18 sec0.81.01.6-0.21.2-1.3
Delay discounting water rate 24 sec2.73.75.0-2.21.6-1.8
Delay discounting water rate 6 sec0.50.81.3-1.1-0.70.6
Locomotor activity0.81.33.2-1.80.7-0.4
Locomotor testing distance0.30.51.4-1.20.30.1
Locomotor testing rearing0.00.00.00.1-0.10.1
Light reinforcement 10.40.72.01.4-0.30.1
Light reinforcement 20.20.30.40.6-0.50.6
Reaction time number correct0.71.02.6-1.60.4-0.4
Reaction time mean minus median1.41.92.11.31.4-1.4
Reaction time mean minus median AUC1.51.93.51.91.0-1.2
Reaction time num false alarms0.20.30.40.00.6-0.6
Reaction time num false alarms AUC0.00.00.00.10.1-0.1
Reaction time trials correct on left0.71.02.6-1.60.4-0.4
Reaction time trials on left0.71.02.6-1.60.4-0.4
Reaction time mean2.33.19.23.00.2-0.3
Reaction time mean AUC2.23.08.93.00.1-0.3
Median of all reaction times2.63.510.33.2-0.30.2
Reaction time omissions0.81.13.01.70.3-0.4
Reaction time false alarm rate0.10.20.40.6-0.20.2
Reaction time premature initiation rate3.14.15.21.72.3-2.1
Reaction time premature initiations2.63.75.70.72.4-2.3
Std. dev. reaction times1.41.93.82.00.9-1.0
Reaction time trials completed0.71.02.6-1.60.4-0.4
Reaction time trials AUC0.60.82.4-1.50.2-0.2
Social response proportion2.32.43.1-1.71.5-1.4
Social responses1.51.93.3-0.51.5-1.8
Social time0.30.41.31.1-0.10.0
Conditioned locomotion0.10.10.20.20.4-0.3
Cocaine response after cond. corrected1.11.32.91.7-0.60.7
Cocaine response after cond. not corrected1.51.63.41.8-0.80.9
Cocaine response before conditioning0.20.20.3-0.0-0.60.5
Saline control response4.35.76.7-2.12.5-2.6
Condit. Reinf. active minus inactive responses1.01.31.7-0.71.3-1.3
Condit. Reinf. active-inactive response ratio1.91.92.7-0.61.7-1.6
Condit. Reinf. active responses0.70.90.9-0.91.0-1.0
Condit. Reinf. inactive responses0.10.10.2-0.5-0.20.2
Condit. Reinf. lever presses0.10.20.2-0.4-0.50.4
Condit. Reinf. lever reinforcers received0.60.91.0-1.00.9-0.9
Pavlov. Cond. lever latency0.00.00.1-0.1-0.30.3
Pavlov. Cond. magazine entry latency0.10.10.20.4-0.00.0
Pavlov. Cond. change in total contacts0.20.20.7-0.80.1-0.2
Pavlov. Cond. index score0.00.10.10.10.3-0.3
Pavlov. Cond. latency score0.00.00.00.20.1-0.1
Pavlov. Cond. lever contacts0.30.40.80.9-0.30.4
Pavlov. Cond. magazine entry number0.10.10.2-0.50.3-0.3
Pavlov. Cond. intertrial magazine entries0.50.71.0-0.50.9-1.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.00.3-0.3
Pavlov. Cond. response bias0.40.51.41.2-0.30.4
Conditioned reinforcement - actives0.90.92.6-1.60.2-0.1
Conditioned reinforcement - inactives0.10.20.40.1-0.30.6
Conditioned locomotion0.40.51.0-1.00.8-0.1
Intermittent access intake day 1-15 change0.50.50.7-0.80.8-0.4
Intermittent access intake escalation0.80.81.0-1.01.0-0.6
Intermittent access intake escalation 20.50.50.8-0.50.9-0.6
Intermitt. access day 1 inactive lever presses0.30.30.6-0.80.3-0.4
Intermitt. access day 15 inactive lever presses1.92.13.81.9-1.40.8
Intermitt. access escalation Index0.10.10.1-0.4-0.0-0.2
Intermittent access day 1 total infusions1.01.12.11.50.7-0.8
Intermittent access day 15 total infusions1.21.32.10.21.5-1.3
Intermittent access terminal intake (last 3 days)0.70.80.90.90.9-0.8
Intermittent access total infusions1.41.51.81.31.2-1.2
Intermittent access day 1 locomotion0.80.82.01.40.6-0.2
Intermittent access day 15 total locomotion1.21.32.30.51.5-1.2
Intermittent access total locomotion1.11.31.71.21.3-0.8
Intermittent access standard deviation0.20.20.4-0.60.4-0.1
Cocaine induced anxiety0.50.60.80.9-0.80.6
Post-drug Anxiety1.41.54.12.00.4-0.5
Baseline Anxiety0.70.72.01.4-0.10.2
Lifetime Intake0.91.02.01.40.6-0.7
Incentive Sensitization - Responses1.01.01.7-0.31.2-1.3
Incentive Sensitization - Breakpoint1.11.11.8-0.31.2-1.4
Progressive ratio test 1 active lever presses0.10.10.3-0.20.6-0.2
Progressive ratio test 1 breakpoint0.50.51.0-0.31.0-0.6
Progressive ratio test 1 inactive lever presses0.20.20.3-0.60.3-0.5
Progressive ratio test 2 active lever presses1.51.62.3-0.91.5-1.2
Progressive ratio test 2 breakpoint1.92.13.3-0.71.8-1.6
Progressive ratio test 2 inactive lever presses1.01.11.7-1.31.0-0.9
Total sessions with >9 infusions0.00.00.0-0.1-0.10.1
Short access day 1 total inactive lever presses0.40.41.0-1.00.5-0.2
Short access day 10 total inactive lever presses0.70.81.0-0.61.0-1.0
Short access day 1 total infusions0.40.40.60.8-0.60.5
Short access day 10 total infusions0.50.51.31.20.1-0.4
Short access total infusions0.40.51.41.2-0.1-0.1
Short access day 1 locomotion0.10.10.30.50.4-0.1
Short access day 10 total locomotion0.40.40.8-0.0-0.70.9
Short access total locomotion0.30.30.70.80.30.1
Compulsive drug intake0.50.51.11.00.2-0.7
One hour access (0.3 mA shock)1.82.13.10.61.7-1.8
One hour access (shock baseline)0.80.91.6-0.41.3-1.0
Number of responses in last shaping day0.00.00.0-0.0-0.10.0
Context. condit. distance diff. score1.01.21.4-0.9-1.21.2
Locomotion velocity, session 11.11.21.7-0.71.3-1.2
Locomotion distance, session 11.41.82.6-0.41.6-1.6
Locomotion velocity, session 22.22.62.7-1.61.6-1.7
Locomotion distance, session 23.44.96.3-1.52.5-2.5
Locomotion velocity, session 30.40.50.8-0.2-0.80.9
Locomotion distance, session 30.10.10.2-0.10.4-0.3
Stereotopy head waving bouts, day 32.12.53.2-1.81.4-1.6
Stereotopy head waving duration, day 30.10.10.2-0.20.3-0.5
Locomotion velocity, session 70.20.20.50.7-0.20.1
Locomotion distance, session 70.10.10.40.60.1-0.1
Stereotopy head waving bouts, day 71.51.72.30.91.4-1.5
Stereotopy head waving duration, day 70.60.71.10.50.9-1.0
Locomotion velocity, session 80.91.01.5-0.51.2-1.2
Locomotion distance, session 80.91.43.5-1.90.6-0.6
Degree of sensitization distance0.20.20.30.50.4-0.5
Degree of sensitization stereotypy0.50.51.01.00.5-0.6
Condit. Reinf. active minus inactive responses0.70.80.9-0.8-0.90.9
Condit. Reinf. active-inactive response ratio1.11.11.7-0.1-1.31.3
Condit. Reinf. active responses0.10.20.4-0.7-0.20.1
Condit. Reinf. inactive responses0.40.50.80.20.9-0.9
Incentive salience index mean0.10.20.2-0.3-0.50.5
Condit. Reinf. lever presses0.10.20.50.7-0.10.1
Time in familiar zone, hab. session 10.20.20.3-0.3-0.50.4
Time in novel zone, hab. session 10.20.20.5-0.70.00.1
Total zone transitions, hab. session 13.24.56.7-0.72.5-2.6
Total locomotion distance, hab. session 10.60.81.20.60.9-1.1
Locomotion velocity, hab. session 11.01.42.01.41.0-1.1
Time in familiar zone, hab. session 22.12.23.30.1-1.81.8
Time in novel zone, hab. session 21.11.11.70.31.3-1.2
Total zone transitions, hab. session 24.15.37.0-1.42.6-2.6
Total locomotion distance, hab. session 21.82.33.60.31.8-1.9
Locomotion velocity, hab. session 21.92.64.10.21.9-2.0
Novel to familiar place preference ratio0.10.10.20.10.5-0.4
Novelty place preference0.00.00.00.10.2-0.2
Time in novel zone, NPP test0.00.00.0-0.10.1-0.1
Total zone transitions, NPP test2.02.93.5-1.51.7-1.9
Total locomotion distance, NPP test0.91.21.90.51.2-1.4
Locomotion velocity, NPP test1.42.03.00.51.7-1.7
Pavlov. Cond. lever latency2.22.93.6-1.9-1.51.6
Pavlov. Cond. magazine entry latency1.92.53.9-0.11.9-2.0
Pavlov. Cond. change in total contacts0.30.30.40.60.5-0.5
Pavlov. Cond. index score1.31.62.20.91.4-1.5
Pavlov. Cond. latency score1.82.23.01.01.6-1.7
Pavlov. Cond. lever contacts2.12.54.12.01.3-1.3
Pavlov. Cond. magazine entry number1.01.21.9-0.0-1.31.4
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.2-0.40.4
Pavlov. Cond. lever-magazine prob. diff.1.01.31.60.91.2-1.3
Pavlov. Cond. response bias1.01.31.80.71.3-1.3
Bone: apparent density3.25.27.9-2.8-2.11.9
Bone surface2.74.810.0-3.2-1.61.3
Bone volume3.35.56.3-2.2-2.52.3
Bone: connectivity density2.94.612.4-3.5-0.90.7
Bone: cortical apparent density0.30.40.70.2-0.90.8
Bone: cortical area1.21.83.1-1.8-1.21.0
Bone: cortical porosity0.91.01.40.51.2-1.1
Bone: cortical porosity0.91.01.40.61.2-1.1
Bone: cortical thickness0.91.52.1-1.4-1.21.0
Bone: cortical thickness0.30.30.70.10.5-0.8
Bone: cortical tissue density0.30.50.70.4-0.80.7
Bone: elastic displacement1.41.52.2-0.51.5-1.5
Bone: elastic work1.31.74.3-2.10.6-0.7
Bone: endosteal estimation0.71.63.7-1.90.7-0.8
Bone: endosteal perimeter0.51.13.2-1.8-0.20.1
Bone: final force0.61.13.0-1.70.2-0.4
Bone: final moment0.61.12.9-1.70.3-0.4
Bone: marrow area0.71.63.5-1.90.7-0.8
Bone: maximum diameter0.81.53.9-2.0-0.60.4
Bone: maximum force0.61.13.2-1.8-0.20.0
Bone: maximum moment0.61.13.1-1.8-0.2-0.0
Bone: minimum diameter0.00.00.0-0.2-0.0-0.2
Bone: periosteal estimation0.91.85.3-2.3-0.1-0.1
Bone: periosteal perimeter0.91.42.6-1.6-1.00.9
Bone: post-yield work0.10.10.2-0.1-0.50.3
Bone: stiffness0.10.20.5-0.7-0.30.2
Bone: tissue strength0.60.61.7-1.3-0.30.3
Bone: trabecular number2.53.87.9-2.8-1.41.3
Bone: trabecular spacing0.70.92.41.6-0.30.3
Bone: trabecular thickness2.42.93.2-1.8-1.71.6
Bone: trabecular tissue density1.11.52.30.6-1.41.5
Breakpoint value in progressive ratio session0.10.10.10.20.4-0.2
Distance traveled before self-admin1.01.11.41.2-1.20.7
Distance traveled after self-admin0.00.00.0-0.00.10.1
Delta time in closed arm before/after self-admin0.30.30.5-0.4-0.70.5
Delta time in open arm before/after self-admin2.62.47.22.70.3-0.1
Diff in mean of infusions in LGA sessions0.40.51.31.2-0.2-0.2
Extinction: sum of active levers before priming0.70.71.3-0.2-0.81.1
Active lever presses in extinction session 61.91.82.9-0.7-1.51.7
Delta distance traveled before/after self-admin1.92.02.9-1.21.7-1.3
Delta ambulatory time before/after self-admin0.91.01.6-0.91.3-0.8
Time in closed arm before self-admin1.01.12.7-1.60.7-0.5
Time in closed arm after self-admin1.92.06.0-2.40.2-0.2
Time in open arm before self-admin0.40.51.0-1.0-0.5-0.4
Time in open arm after self-admin0.80.92.81.7-0.0-0.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.2-0.20.4
Time to tail flick, vehicle, before self-admin0.10.10.20.5-0.10.3
Time to tail flick, vehicle, after self-admin0.20.20.6-0.8-0.10.1
Time to tail flick, test, before self-admin0.70.71.7-1.3-0.40.4
Time to tail flick, test, after self-admin0.60.71.30.2-0.81.1
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.0-0.80.6
Delta time to tail flick, test, before/after SA0.20.20.60.80.20.1
Ambulatory time before self-admin0.40.40.70.8-0.60.3
Ambulatory time after self-admin0.00.00.0-0.00.10.1
Total heroin consumption1.21.44.12.0-0.10.2
Area under the delay curve0.50.50.60.70.8-0.6
Delay disc. indifference point, 0s delay0.10.10.1-0.3-0.20.2
Delay disc. indifference point, 16s delay0.30.30.90.9-0.10.2
Delay disc. indifference point, 2s delay0.60.72.01.40.3-0.1
Delay disc. indifference point, 24s delay0.20.20.30.50.4-0.5
Delay disc. indifference point, 4s delay0.30.40.70.80.5-0.4
Delay disc. indifference point, 8s delay0.30.40.50.50.7-0.6
Delay discount exponential model param0.60.61.0-1.0-0.70.6
Delay discount hyperbolic model param0.60.60.9-1.0-0.80.6
Fecal boli incidents, locomotor time 10.80.82.5-1.6-0.10.2
Change in fecal boli incidents, locomotor task0.70.71.91.4-0.30.2
Time >=10cm from walls, locomotor time 10.60.60.90.9-0.80.5
Bouts of movement, locomotor time 10.20.20.3-0.60.4-0.3
Total resting periods, locomotor time 10.00.00.1-0.20.2-0.2
Rest time, locomotor task time 10.60.61.00.11.0-0.9
Distance moved, locomotor task time 10.20.20.5-0.7-0.20.2
Vertical activity count, locomotor time 10.70.81.7-1.3-0.40.7
Time >=10cm from walls, locomotor time 20.50.60.8-0.6-0.70.9
Bouts of movement, locomotor time 21.41.53.9-2.0-0.50.7
Total resting periods, locomotor time 21.41.52.9-1.7-0.81.0
Rest time, locomotor task time 20.30.41.11.10.0-0.2
Distance moved, locomotor task time 21.01.23.2-1.80.7-0.0
Vertical activity count, locomotor time 22.22.47.1-2.70.40.3
Weight adjusted by age2.22.44.9-2.21.2-1.0
Seeking ratio, delayed vs. immediate footshock1.11.33.71.9-0.20.4
Locomotion in novel chamber3.23.96.3-0.82.5-2.2
Locomotion in novel chamber post-restriction5.46.57.8-2.32.5-2.8
Progressive ratio0.30.40.60.70.2-0.8
Food seeking constrained by brief footshock0.10.10.1-0.4-0.30.4
Seeking ratio, punishment vs. effort0.60.72.0-1.40.10.5
Run reversals in cocaine runway, females0.40.40.70.80.3-0.6
Run reversals in cocaine runway, males0.80.70.9-0.9-0.71.0
Latency to leave start box in cocaine runway3.63.95.41.2-2.22.3
Latency to leave start box in cocaine runway, F4.95.48.80.9-2.53.0
Latency to leave start box in cocaine runway, M0.30.30.70.20.4-0.8
Cd content in liver0.40.40.70.10.8-0.7
Co content in liver1.41.62.20.71.5-1.5
Cu content in liver1.41.71.9-1.3-1.31.4
Fe content in liver6.57.810.4-1.9-3.13.2
K content in liver0.40.40.60.40.6-0.8
Mg content in liver0.40.40.50.60.6-0.7
Mn content in liver0.20.30.4-0.60.4-0.5
Na content in liver0.00.00.0-0.10.0-0.1
Rb content in liver1.92.44.42.1-1.21.1
Se content in liver2.32.84.20.4-2.02.1
Sr content in liver1.51.42.2-1.50.9-1.0
Zn content in liver1.82.05.1-2.3-0.60.7