Hub : Genes

Rhebl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000054385	0.03	0.03	1.0e-03	0.01	0.01	0.01	0.01	1.0e-02	7.5e-03	9.7e-03	1.1e-02
2	Brain	intron excision ratio	chr7:130028333:130029695	0.04	0.05	3.1e-03	0.02	0.02	0.01	0.02	6.0e-03	5.0e-03	2.2e-02	9.5e-03
3	NAcc	intron excision ratio	chr7:130028333:130029361	0.03	0.03	6.9e-03	0.02	0.01	0.01	0.01	2.1e-02	3.5e-02	1.1e-01	4.4e-02
4	NAcc	intron excision ratio	chr7:130028333:130029695	0.04	0.04	1.9e-03	0.03	0.03	0.03	0.03	2.1e-03	3.0e-03	2.4e-03	2.9e-03
5	PL	intron excision ratio	chr7:130028333:130029695	0.04	0.04	2.1e-03	0.03	0.03	0.02	0.03	2.0e-03	3.1e-03	8.5e-03	4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	4.5	14.7	15.0	-3.8	-3.7	3.9	-3.9	-3.9
BMI without tail	0.0	0.0	0.1	0.1	0.2	0.3	-0.3	-0.3
Body weight	6.5	27.5	28.3	-5.2	-5.1	5.3	-5.3	-5.3
Epididymis fat weight	0.1	0.3	0.4	-0.6	-0.6	0.4	-0.4	-0.4
Glucose	0.1	0.2	0.2	-0.3	-0.2	0.5	-0.5	-0.5
Heart weight	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.2	-0.2
Left kidney weight	0.4	1.1	1.2	-1.0	-1.0	1.1	-1.1	-1.1
Right kidney weight	2.8	8.0	8.2	-2.8	-2.8	2.9	-2.9	-2.9
Tail length	0.1	0.2	0.3	0.5	0.6	-0.4	0.4	0.4
Length with tail	2.0	7.2	7.3	-2.7	-2.7	2.7	-2.7	-2.7
Length without tail	7.7	16.9	17.4	-4.2	-4.1	4.1	-4.1	-4.1
Liver weight, left	2.1	3.4	3.6	-1.8	-1.7	1.9	-1.9	-1.9
Liver weight, right	1.6	2.6	2.7	-1.6	-1.6	1.6	-1.6	-1.6
Parametrial fat weight	1.9	3.8	4.3	2.0	2.1	-1.9	1.9	1.9
Retroperitoneal fat weight	0.3	1.0	1.6	1.2	1.3	-0.8	0.8	0.8
Intraocular pressure	7.6	10.7	11.0	3.3	3.3	-3.2	3.2	3.2
Extensor digitorum longus weight	4.6	18.3	20.0	-4.1	-3.9	4.5	-4.5	-4.5
Soleus weight	0.6	1.7	1.8	-1.3	-1.3	1.3	-1.3	-1.3
Tibialis anterior weight	1.3	4.4	5.4	-1.8	-1.6	2.3	-2.3	-2.3
Tibia length	7.8	21.9	22.2	-4.7	-4.6	4.7	-4.7	-4.7
Number of licking bursts	0.2	0.2	0.5	0.6	0.7	-0.3	0.3	0.3
Food consumed during 24 hour testing period	1.9	2.2	2.3	-1.5	-1.5	1.5	-1.5	-1.5
Times rat made contact with spout	0.0	0.0	0.1	0.2	0.3	-0.0	0.0	0.0
Mean time between licks in bursts	0.1	0.2	0.3	0.3	0.2	-0.5	0.5	0.5
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1
Std. dev. time between licks in bursts	0.9	1.1	1.3	1.1	1.1	-1.0	1.0	1.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0	-0.0
Indifference point 0 sec	2.2	3.6	3.7	1.9	1.9	-1.9	1.9	1.9
Indifference point AUC	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	0.5
Indifference point function ln k	3.6	5.0	5.6	-2.3	-2.4	2.2	-2.2	-2.2
Indifference point function log k	3.6	5.0	5.6	-2.3	-2.4	2.2	-2.2	-2.2
Delay discounting total patch changes 0 sec	2.2	3.5	3.5	1.9	1.9	-1.9	1.9	1.9
Delay discounting total patch changes 12 sec	1.7	2.3	2.9	1.6	1.7	-1.4	1.4	1.4
Delay discounting total patch changes 18 sec	4.4	5.9	6.1	2.4	2.3	-2.5	2.5	2.5
Delay discounting total patch changes 24 sec	1.7	2.2	2.6	1.6	1.6	-1.4	1.4	1.4
Delay discounting total patch changes 6 sec	2.4	3.7	3.8	2.0	2.0	-1.9	1.9	1.9
Delay discounting time to switch 0 sec	2.3	3.6	3.6	1.9	1.9	-1.9	1.9	1.9
Delay discounting water rate 0 sec	3.1	4.9	4.9	-2.2	-2.2	2.2	-2.2	-2.2
Delay discounting water rate 12 sec	3.8	5.6	6.0	-2.4	-2.4	2.3	-2.3	-2.3
Delay discounting water rate 18 sec	0.4	0.5	0.6	-0.6	-0.6	0.8	-0.8	-0.8
Delay discounting water rate 24 sec	3.2	4.4	4.6	-2.1	-2.1	2.1	-2.1	-2.1
Delay discounting water rate 6 sec	3.9	5.6	5.7	-2.4	-2.4	2.4	-2.4	-2.4
Locomotor activity	0.8	1.3	1.9	1.3	1.4	-1.0	1.0	1.0
Locomotor testing distance	2.8	4.6	5.1	2.3	2.3	-2.1	2.1	2.1
Locomotor testing rearing	2.4	3.7	3.8	1.9	1.9	-1.9	1.9	1.9
Light reinforcement 1	2.6	4.7	5.4	2.3	2.3	-2.1	2.1	2.1
Light reinforcement 2	0.6	0.7	1.3	1.1	1.1	-0.6	0.6	0.6
Reaction time number correct	1.4	2.0	2.4	-1.4	-1.6	1.3	-1.3	-1.3
Reaction time mean minus median	8.8	11.4	11.6	3.3	3.4	-3.4	3.4	3.4
Reaction time mean minus median AUC	6.6	8.5	8.8	2.8	2.8	-3.0	3.0	3.0
Reaction time num false alarms	1.9	2.6	2.8	1.5	1.5	-1.7	1.7	1.7
Reaction time num false alarms AUC	2.6	3.7	3.9	1.8	1.8	-2.0	2.0	2.0
Reaction time trials correct on left	1.4	2.0	2.4	-1.4	-1.6	1.3	-1.3	-1.3
Reaction time trials on left	1.1	1.5	1.9	-1.3	-1.4	1.2	-1.2	-1.2
Reaction time mean	0.6	0.9	1.0	0.9	1.0	-0.9	0.9	0.9
Reaction time mean AUC	0.3	0.5	0.5	0.7	0.7	-0.7	0.7	0.7
Median of all reaction times	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2	-0.2
Reaction time omissions	10.3	13.9	14.1	3.8	3.7	-3.7	3.7	3.7
Reaction time false alarm rate	2.9	4.1	4.2	2.0	2.0	-2.0	2.0	2.0
Reaction time premature initiation rate	5.6	7.5	9.4	3.0	3.1	-2.6	2.6	2.6
Reaction time premature initiations	2.5	3.6	4.4	2.1	2.1	-1.7	1.7	1.7
Std. dev. reaction times	6.5	8.9	9.0	3.0	3.0	-3.0	3.0	3.0
Reaction time trials completed	1.1	1.5	1.9	-1.3	-1.4	1.2	-1.2	-1.2
Reaction time trials AUC	1.7	2.4	3.0	-1.6	-1.7	1.5	-1.5	-1.5
Social response proportion	0.0	0.1	0.1	0.3	0.4	-0.1	0.1	0.1
Social responses	7.3	9.4	10.5	3.2	3.2	-3.0	3.0	3.0
Social time	0.0	0.0	0.0	0.0	0.1	0.0	-0.0	-0.0
Conditioned locomotion	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.1	-0.1
Cocaine response after cond. corrected	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Cocaine response after cond. not corrected	0.6	0.7	0.8	0.8	0.8	-0.9	0.9	0.9
Cocaine response before conditioning	3.9	4.8	5.1	2.1	2.1	-2.3	2.3	2.3
Saline control response	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	0.1	-0.3	0.3	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	0.6	0.6	-0.6	0.6	0.6
Condit. Reinf. active responses	0.3	0.4	0.5	0.5	0.5	-0.7	0.7	0.7
Condit. Reinf. inactive responses	0.7	0.9	0.9	0.9	0.9	-1.0	1.0	1.0
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1
Condit. Reinf. lever reinforcers received	0.6	0.9	1.0	0.9	0.8	-1.0	1.0	1.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0	0.0
Pavlov. Cond. magazine entry latency	0.9	1.1	1.3	-1.1	-1.2	1.0	-1.0	-1.0
Pavlov. Cond. change in total contacts	1.7	2.3	2.6	-1.4	-1.3	1.6	-1.6	-1.6
Pavlov. Cond. index score	0.5	0.7	0.7	-0.8	-0.8	0.8	-0.8	-0.8
Pavlov. Cond. latency score	0.6	0.7	0.7	-0.8	-0.8	0.9	-0.9	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.4	-0.3	0.3	0.3
Pavlov. Cond. magazine entry number	2.2	2.7	2.8	1.7	1.7	-1.6	1.6	1.6
Pavlov. Cond. intertrial magazine entries	4.9	6.3	6.9	2.6	2.6	-2.4	2.4	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.2	-1.1	-1.1	1.1	-1.1	-1.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.0	0.1	0.0	-0.0	-0.0
Conditioned reinforcement - actives	1.5	1.5	1.7	1.3	1.3	-1.2	1.2	1.2
Conditioned reinforcement - inactives	1.7	1.9	2.4	1.5	1.6	-1.3	1.3	1.3
Conditioned locomotion	0.4	0.4	0.5	0.7	0.7	-0.6	0.6	0.6
Intermittent access intake day 1-15 change	1.3	1.3	1.5	1.2	1.2	-1.0	1.0	1.0
Intermittent access intake escalation	0.9	0.9	1.1	1.0	1.0	-0.9	0.9	0.9
Intermittent access intake escalation 2	1.3	1.3	1.7	1.3	1.3	-1.1	1.1	1.1
Intermitt. access day 1 inactive lever presses	3.4	3.7	4.0	1.8	1.7	-2.0	2.0	2.0
Intermitt. access day 15 inactive lever presses	1.3	1.5	1.5	1.2	1.2	-1.2	1.2	1.2
Intermitt. access escalation Index	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Intermittent access day 1 total infusions	1.1	1.3	1.4	1.2	1.2	-1.1	1.1	1.1
Intermittent access day 15 total infusions	2.4	2.7	3.2	1.8	1.8	-1.5	1.5	1.5
Intermittent access terminal intake (last 3 days)	2.8	3.0	3.4	1.8	1.8	-1.7	1.7	1.7
Intermittent access total infusions	2.4	2.6	3.1	1.7	1.8	-1.5	1.5	1.5
Intermittent access day 1 locomotion	1.0	1.0	1.1	1.0	1.0	-1.0	1.0	1.0
Intermittent access day 15 total locomotion	1.5	1.6	1.8	1.3	1.4	-1.2	1.2	1.2
Intermittent access total locomotion	3.3	3.7	4.0	2.0	2.0	-1.9	1.9	1.9
Intermittent access standard deviation	0.4	0.5	0.6	0.7	0.8	-0.6	0.6	0.6
Cocaine induced anxiety	1.2	1.4	1.5	-1.1	-1.1	1.2	-1.2	-1.2
Post-drug Anxiety	5.2	5.8	5.8	-2.4	-2.4	2.4	-2.4	-2.4
Baseline Anxiety	1.1	1.1	1.2	-1.1	-1.0	1.1	-1.1	-1.1
Lifetime Intake	2.0	2.3	3.0	1.7	1.7	-1.4	1.4	1.4
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Progressive ratio test 1 active lever presses	4.1	4.2	5.0	2.2	2.2	-1.9	1.9	1.9
Progressive ratio test 1 breakpoint	3.7	3.8	4.6	2.1	2.1	-1.8	1.8	1.8
Progressive ratio test 1 inactive lever presses	3.7	3.9	4.3	2.0	2.1	-1.9	1.9	1.9
Progressive ratio test 2 active lever presses	2.1	2.2	2.8	1.6	1.7	-1.4	1.4	1.4
Progressive ratio test 2 breakpoint	2.8	3.1	3.7	1.9	1.9	-1.6	1.6	1.6
Progressive ratio test 2 inactive lever presses	2.6	3.0	3.1	1.8	1.8	-1.7	1.7	1.7
Total sessions with >9 infusions	0.5	0.6	1.1	1.0	1.1	-0.5	0.5	0.5
Short access day 1 total inactive lever presses	1.2	1.3	1.8	1.3	1.3	-1.0	1.0	1.0
Short access day 10 total inactive lever presses	0.3	0.4	0.5	0.5	0.5	-0.7	0.7	0.7
Short access day 1 total infusions	0.0	0.0	0.1	0.2	0.2	0.1	-0.1	-0.1
Short access day 10 total infusions	0.7	0.7	1.2	1.0	1.1	-0.7	0.7	0.7
Short access total infusions	0.3	0.3	0.7	0.7	0.8	-0.3	0.3	0.3
Short access day 1 locomotion	0.1	0.1	0.1	0.3	0.4	-0.1	0.1	0.1
Short access day 10 total locomotion	0.2	0.2	0.2	0.4	0.4	-0.5	0.5	0.5
Short access total locomotion	0.4	0.4	0.5	0.7	0.7	-0.5	0.5	0.5
Compulsive drug intake	0.9	0.9	1.1	-1.0	-1.0	0.9	-0.9	-0.9
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.5	0.6	-0.3	0.3	0.3
One hour access (shock baseline)	0.1	0.1	0.3	0.4	0.5	-0.1	0.1	0.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.4	-0.4
Context. condit. distance diff. score	0.3	0.4	0.4	-0.6	-0.5	0.7	-0.7	-0.7
Locomotion velocity, session 1	1.2	1.2	1.3	1.1	1.1	-1.1	1.1	1.1
Locomotion distance, session 1	2.9	3.8	3.9	1.9	1.9	-2.0	2.0	2.0
Locomotion velocity, session 2	0.3	0.3	0.4	0.5	0.5	-0.6	0.6	0.6
Locomotion distance, session 2	2.3	3.3	3.4	1.8	1.8	-1.9	1.9	1.9
Locomotion velocity, session 3	3.8	4.4	4.7	2.2	2.1	-2.1	2.1	2.1
Locomotion distance, session 3	5.1	5.5	5.8	2.4	2.3	-2.3	2.3	2.3
Stereotopy head waving bouts, day 3	1.2	1.4	1.5	-1.2	-1.2	1.2	-1.2	-1.2
Stereotopy head waving duration, day 3	0.5	0.5	0.7	-0.8	-0.9	0.7	-0.7	-0.7
Locomotion velocity, session 7	0.1	0.2	0.2	0.5	0.5	-0.3	0.3	0.3
Locomotion distance, session 7	1.4	1.8	2.2	1.5	1.5	-1.3	1.3	1.3
Stereotopy head waving bouts, day 7	1.0	1.2	1.2	-1.0	-1.0	1.1	-1.1	-1.1
Stereotopy head waving duration, day 7	1.2	1.5	1.5	-1.2	-1.2	1.2	-1.2	-1.2
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1	-0.1
Locomotion distance, session 8	1.2	1.7	1.7	1.3	1.3	-1.3	1.3	1.3
Degree of sensitization distance	0.6	0.6	0.6	-0.7	-0.7	0.8	-0.8	-0.8
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.4	-0.4	0.5	-0.5	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	-0.5
Condit. Reinf. active responses	0.5	0.6	0.7	0.8	0.8	-0.8	0.8	0.8
Condit. Reinf. inactive responses	2.8	3.3	3.4	1.8	1.8	-1.8	1.8	1.8
Incentive salience index mean	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.5	-0.4	0.7	-0.7	-0.7
Time in familiar zone, hab. session 1	0.3	0.3	0.3	0.5	0.5	-0.6	0.6	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.5	-0.5	0.5	-0.5	-0.5
Total zone transitions, hab. session 1	0.3	0.4	0.5	0.7	0.7	-0.6	0.6	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	0.0	-0.0	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.6	-0.6	0.4	-0.4	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.2	0.5	0.5	-0.4	0.4	0.4
Total zone transitions, hab. session 2	0.3	0.3	0.4	0.6	0.6	-0.5	0.5	0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.3	0.2	-0.4	0.4	0.4
Locomotion velocity, hab. session 2	0.0	0.0	0.0	0.1	0.1	-0.2	0.2	0.2
Novel to familiar place preference ratio	1.8	1.9	1.9	-1.4	-1.3	1.4	-1.4	-1.4
Novelty place preference	1.2	1.3	1.3	-1.1	-1.1	1.1	-1.1	-1.1
Time in novel zone, NPP test	1.0	1.0	1.1	-1.0	-1.0	1.0	-1.0	-1.0
Total zone transitions, NPP test	1.1	1.5	1.9	1.3	1.4	-1.2	1.2	1.2
Total locomotion distance, NPP test	1.7	2.3	2.4	1.5	1.5	-1.5	1.5	1.5
Locomotion velocity, NPP test	0.8	1.2	1.2	1.1	1.1	-1.1	1.1	1.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2	0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	-0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.4	-0.4
Pavlov. Cond. index score	0.1	0.2	0.3	-0.2	-0.1	0.6	-0.6	-0.6
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.1	0.0	0.5	-0.5	-0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.7	0.8	-0.3	0.3	0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	0.6	0.6	-0.7	0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.5	-0.4	0.9	-0.9	-0.9
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	0.3	-0.1	0.1	0.1
Bone: apparent density	10.6	17.5	18.2	-4.2	-4.3	4.1	-4.1	-4.1
Bone surface	12.3	21.6	22.4	-4.7	-4.7	4.6	-4.6	-4.6
Bone volume	9.2	15.6	16.3	-4.0	-4.0	3.9	-3.9	-3.9
Bone: connectivity density	7.5	11.8	12.5	-3.5	-3.5	3.4	-3.4	-3.4
Bone: cortical apparent density	0.3	0.4	0.5	0.6	0.6	-0.7	0.7	0.7
Bone: cortical area	10.4	15.7	16.2	-3.9	-3.8	4.0	-4.0	-4.0
Bone: cortical porosity	1.2	1.3	1.6	1.0	0.9	-1.3	1.3	1.3
Bone: cortical porosity	1.7	1.9	2.2	1.2	1.1	-1.5	1.5	1.5
Bone: cortical thickness	4.2	7.0	7.7	-2.5	-2.4	2.8	-2.8	-2.8
Bone: cortical thickness	0.2	0.3	0.3	-0.4	-0.3	0.6	-0.6	-0.6
Bone: cortical tissue density	0.5	0.6	0.6	0.7	0.7	-0.8	0.8	0.8
Bone: elastic displacement	4.8	5.4	5.7	2.3	2.2	-2.4	2.4	2.4
Bone: elastic work	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.2	0.2
Bone: endosteal estimation	7.5	16.1	17.6	-4.1	-4.2	3.9	-3.9	-3.9
Bone: endosteal perimeter	7.0	14.5	14.6	-3.8	-3.8	3.8	-3.8	-3.8
Bone: final force	10.3	16.8	17.2	-4.1	-4.1	4.1	-4.1	-4.1
Bone: final moment	10.5	17.3	18.2	-4.2	-4.3	4.1	-4.1	-4.1
Bone: marrow area	7.3	15.7	17.2	-4.1	-4.1	3.9	-3.9	-3.9
Bone: maximum diameter	4.2	7.8	8.3	-2.7	-2.6	2.9	-2.9	-2.9
Bone: maximum force	13.9	24.2	26.1	-5.1	-5.1	4.8	-4.8	-4.8
Bone: maximum moment	14.1	24.5	27.3	-5.1	-5.2	4.8	-4.8	-4.8
Bone: minimum diameter	9.3	17.1	17.4	-4.2	-4.2	4.1	-4.1	-4.1
Bone: periosteal estimation	12.3	25.2	25.4	-5.0	-5.0	5.0	-5.0	-5.0
Bone: periosteal perimeter	10.7	17.8	17.9	-4.2	-4.2	4.2	-4.2	-4.2
Bone: post-yield work	7.7	10.4	12.1	-3.4	-3.5	3.1	-3.1	-3.1
Bone: stiffness	16.6	26.3	28.0	-5.3	-5.3	5.0	-5.0	-5.0
Bone: tissue strength	0.8	0.8	1.2	-1.0	-1.1	0.8	-0.8	-0.8
Bone: trabecular number	6.1	9.5	10.9	-3.2	-3.3	3.0	-3.0	-3.0
Bone: trabecular spacing	2.1	2.8	3.3	1.8	1.8	-1.6	1.6	1.6
Bone: trabecular thickness	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.3
Bone: trabecular tissue density	0.1	0.1	0.1	0.3	0.3	-0.4	0.4	0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.5	-0.5	0.4	-0.4	-0.4
Distance traveled before self-admin	1.0	1.1	1.2	1.1	1.1	-1.0	1.0	1.0
Distance traveled after self-admin	0.2	0.2	0.2	0.4	0.4	-0.5	0.5	0.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.4	-0.4	-0.4
Delta time in open arm before/after self-admin	4.1	3.9	4.3	2.1	2.1	-1.9	1.9	1.9
Diff in mean of infusions in LGA sessions	1.5	1.6	1.8	-1.3	-1.3	1.2	-1.2	-1.2
Extinction: sum of active levers before priming	0.4	0.4	0.5	-0.7	-0.7	0.6	-0.6	-0.6
Active lever presses in extinction session 6	0.5	0.5	0.5	-0.7	-0.7	0.7	-0.7	-0.7
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.3	-0.3	0.1	-0.1	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0	0.0
Time in closed arm before self-admin	1.4	1.6	1.7	-1.3	-1.3	1.3	-1.3	-1.3
Time in closed arm after self-admin	0.6	0.6	0.8	-0.9	-0.9	0.7	-0.7	-0.7
Time in open arm before self-admin	0.6	0.6	0.8	-0.8	-0.9	0.7	-0.7	-0.7
Time in open arm after self-admin	0.3	0.3	0.3	0.5	0.6	-0.5	0.5	0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.2	0.1	-0.3	0.3	0.3
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.0	1.0	1.0	-1.0	1.0	1.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	-0.5
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.6	0.5	-0.8	0.8	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	-0.5	0.3	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.6	-0.7	-0.6	0.8	-0.8	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.4	-0.4	0.5	-0.5	-0.5
Ambulatory time before self-admin	3.9	4.1	4.2	2.0	2.1	-2.0	2.0	2.0
Ambulatory time after self-admin	1.7	1.9	2.0	1.4	1.4	-1.3	1.3	1.3
Total heroin consumption	1.6	1.9	2.2	-1.5	-1.5	1.3	-1.3	-1.3
Area under the delay curve	1.1	1.1	1.2	-1.0	-1.0	1.1	-1.1	-1.1
Delay disc. indifference point, 0s delay	1.1	1.2	1.3	-1.1	-1.1	1.0	-1.0	-1.0
Delay disc. indifference point, 16s delay	1.2	1.3	1.5	-1.0	-0.9	1.2	-1.2	-1.2
Delay disc. indifference point, 2s delay	1.3	1.4	1.6	-1.3	-1.3	1.1	-1.1	-1.1
Delay disc. indifference point, 24s delay	1.4	1.3	1.4	-1.2	-1.1	1.2	-1.2	-1.2
Delay disc. indifference point, 4s delay	0.2	0.3	0.3	-0.5	-0.5	0.5	-0.5	-0.5
Delay disc. indifference point, 8s delay	2.9	3.0	3.2	-1.7	-1.6	1.8	-1.8	-1.8
Delay discount exponential model param	1.0	1.0	1.1	1.0	0.9	-1.0	1.0	1.0
Delay discount hyperbolic model param	0.9	0.9	1.0	1.0	0.9	-1.0	1.0	1.0
Fecal boli incidents, locomotor time 1	1.6	1.8	2.4	1.5	1.5	-1.2	1.2	1.2
Change in fecal boli incidents, locomotor task	1.6	1.5	1.5	-1.2	-1.2	1.2	-1.2	-1.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.4	-0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Rest time, locomotor task time 1	0.3	0.3	0.4	0.6	0.6	-0.5	0.5	0.5
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	0.1
Vertical activity count, locomotor time 1	1.3	1.4	1.4	-1.2	-1.2	1.2	-1.2	-1.2
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.7	0.8	0.8	-0.6	0.6	0.6
Bouts of movement, locomotor time 2	2.3	2.5	2.8	-1.7	-1.7	1.5	-1.5	-1.5
Total resting periods, locomotor time 2	2.7	2.9	3.2	-1.8	-1.8	1.6	-1.6	-1.6
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.2	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.3	0.3	-0.4	0.4	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2	-0.2
Weight adjusted by age	2.5	2.8	3.1	-1.6	-1.5	1.8	-1.8	-1.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.4	-0.6	-0.6	0.7	-0.7	-0.7
Locomotion in novel chamber	0.5	0.6	0.7	-0.8	-0.8	0.7	-0.7	-0.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2	-0.2
Progressive ratio	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	0.2
Food seeking constrained by brief footshock	0.2	0.3	0.4	0.6	0.7	-0.4	0.4	0.4
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.0	0.1	0.0	-0.0	-0.0
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.1	0.0	-0.2	0.2	0.2
Run reversals in cocaine runway, males	1.4	1.4	1.5	1.2	1.2	-1.1	1.1	1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	0.1	-0.3	0.3	0.3
Latency to leave start box in cocaine runway, F	2.1	2.3	2.5	1.4	1.4	-1.6	1.6	1.6
Latency to leave start box in cocaine runway, M	1.9	1.9	2.1	-1.4	-1.4	1.3	-1.3	-1.3
Cd content in liver	0.4	0.5	0.8	0.8	0.9	-0.5	0.5	0.5
Co content in liver	0.2	0.3	0.8	0.7	0.9	-0.1	0.1	0.1
Cu content in liver	1.1	1.3	1.6	-1.0	-0.9	1.3	-1.3	-1.3
Fe content in liver	0.2	0.2	0.5	0.6	0.7	-0.2	0.2	0.2
K content in liver	0.4	0.4	0.5	-0.5	-0.4	0.7	-0.7	-0.7
Mg content in liver	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Mn content in liver	0.0	0.0	0.1	-0.2	-0.3	0.0	-0.0	-0.0
Na content in liver	0.0	0.0	0.1	0.2	0.2	-0.0	0.0	0.0
Rb content in liver	0.2	0.3	0.5	0.6	0.7	-0.4	0.4	0.4
Se content in liver	0.5	0.6	0.8	0.9	0.9	-0.7	0.7	0.7
Sr content in liver	0.7	0.6	0.8	-0.6	-0.5	0.9	-0.9	-0.9
Zn content in liver	1.4	1.5	2.3	1.4	1.5	-1.1	1.1	1.1