Hub : Genes

Elp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000020847	0.06	0.06	2.1e-03	0.03	0.03	0.02	0.02	6.7e-03	9.8e-03	2.0e-02	2.2e-02
2	Brain	isoform ratio	ENSRNOT00000028288	0.03	0.03	3.7e-03	0.02	0.02	0.01	0.01	8.6e-03	4.4e-03	7.7e-02	1.5e-02
3	Brain	isoform ratio	ENSRNOT00000107416	0.03	0.03	3.3e-03	0.02	0.02	0	0.01	7.9e-03	4.1e-03	2.0e-01	1.5e-02
4	NAcc	intron excision ratio	chr8:110290154:110293812	0.05	0.05	1.6e-03	0.04	0.03	0.03	0.03	1.3e-03	1.7e-03	2.0e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.4	1.3	2.0	1.4	1.0	-1.0	-1.0
BMI without tail	1.8	3.7	4.2	2.0	1.9	-1.9	-1.8
Body weight	6.5	27.6	29.6	5.4	5.3	-5.3	-5.0
Epididymis fat weight	0.3	0.7	1.0	1.0	0.8	-0.8	-0.7
Glucose	0.3	0.5	0.7	0.8	0.7	-0.7	-0.6
Heart weight	2.5	3.6	4.2	2.1	1.9	-1.9	-1.7
Left kidney weight	0.9	2.5	3.8	2.0	1.5	-1.5	-1.3
Right kidney weight	0.2	0.6	1.0	1.0	0.7	-0.7	-0.7
Tail length	6.9	20.7	21.7	4.5	4.7	-4.7	-4.4
Length with tail	9.4	34.6	36.2	5.9	6.0	-6.0	-5.5
Length without tail	6.4	14.1	14.6	3.8	3.8	-3.8	-3.6
Liver weight, left	0.0	0.1	0.1	0.2	0.3	-0.3	-0.3
Liver weight, right	1.4	2.3	2.4	1.5	1.5	-1.5	-1.5
Parametrial fat weight	1.3	2.5	2.8	1.7	1.6	-1.6	-1.5
Retroperitoneal fat weight	0.6	2.0	2.7	1.6	1.5	-1.5	-1.0
Intraocular pressure	0.9	1.3	1.4	1.1	1.2	-1.2	-1.1
Extensor digitorum longus weight	0.1	0.6	0.7	-0.8	-0.8	0.8	0.6
Soleus weight	3.7	10.9	11.9	3.5	3.3	-3.3	-3.1
Tibialis anterior weight	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1
Tibia length	6.8	19.2	21.1	4.6	4.4	-4.4	-4.1
Number of licking bursts	0.2	0.3	0.4	-0.6	-0.5	0.5	0.5
Food consumed during 24 hour testing period	1.5	1.8	2.1	1.4	1.3	-1.3	-1.3
Times rat made contact with spout	0.6	0.7	0.9	0.9	0.8	-0.8	-0.9
Mean time between licks in bursts	1.3	1.9	2.0	-1.3	-1.3	1.3	1.4
Mean num. licks in bursts	0.9	1.1	1.3	1.2	0.9	-0.9	-1.1
Std. dev. time between licks in bursts	5.0	5.9	6.4	-2.5	-2.4	2.4	2.5
Water consumed over 24 hours	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Indifference point 0 sec	1.1	1.8	2.2	1.3	1.3	-1.3	-1.5
Indifference point AUC	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Indifference point function ln k	0.2	0.3	0.7	-0.3	-0.6	0.6	0.8
Indifference point function log k	0.2	0.3	0.7	-0.3	-0.6	0.6	0.8
Delay discounting total patch changes 0 sec	1.3	2.1	2.5	1.4	1.4	-1.4	-1.6
Delay discounting total patch changes 12 sec	1.0	1.4	1.5	1.1	1.2	-1.2	-1.2
Delay discounting total patch changes 18 sec	2.3	3.0	3.5	1.6	1.8	-1.8	-1.9
Delay discounting total patch changes 24 sec	2.9	3.7	3.8	1.9	2.0	-2.0	-1.9
Delay discounting total patch changes 6 sec	0.2	0.3	0.3	0.5	0.5	-0.5	-0.6
Delay discounting time to switch 0 sec	0.1	0.2	0.2	-0.5	-0.4	0.4	0.3
Delay discounting water rate 0 sec	0.1	0.2	0.3	0.5	0.4	-0.4	-0.4
Delay discounting water rate 12 sec	0.2	0.3	0.4	0.6	0.6	-0.6	-0.4
Delay discounting water rate 18 sec	0.0	0.0	0.1	0.2	0.1	-0.1	0.1
Delay discounting water rate 24 sec	0.7	1.0	1.2	1.1	1.0	-1.0	-0.9
Delay discounting water rate 6 sec	0.3	0.4	0.6	0.8	0.6	-0.6	-0.4
Locomotor activity	5.5	8.8	9.0	2.8	3.0	-3.0	-3.0
Locomotor testing distance	4.8	8.0	8.7	2.7	3.0	-3.0	-2.7
Locomotor testing rearing	0.1	0.1	0.2	0.0	0.4	-0.4	-0.3
Light reinforcement 1	0.6	1.2	1.3	1.1	1.2	-1.2	-0.9
Light reinforcement 2	0.1	0.2	0.5	-0.2	-0.3	0.3	0.7
Reaction time number correct	0.5	0.7	1.1	-0.7	-0.7	0.7	1.0
Reaction time mean minus median	0.1	0.1	0.1	0.2	0.2	-0.2	-0.3
Reaction time mean minus median AUC	0.2	0.3	0.4	0.5	0.5	-0.5	-0.6
Reaction time num false alarms	0.3	0.5	0.7	-0.8	-0.6	0.6	0.7
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.4	-0.2	0.2	0.3
Reaction time trials correct on left	0.5	0.7	1.1	-0.7	-0.7	0.7	1.0
Reaction time trials on left	0.5	0.7	1.1	-0.8	-0.8	0.8	1.1
Reaction time mean	0.0	0.0	0.0	0.0	0.0	-0.0	0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1
Median of all reaction times	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1
Reaction time omissions	0.2	0.2	0.3	-0.6	-0.5	0.5	0.3
Reaction time false alarm rate	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.0
Reaction time premature initiation rate	2.5	3.4	4.2	1.7	1.8	-1.8	-2.0
Reaction time premature initiations	1.1	1.6	1.7	1.2	1.2	-1.2	-1.3
Std. dev. reaction times	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4
Reaction time trials completed	0.5	0.7	1.1	-0.8	-0.8	0.8	1.1
Reaction time trials AUC	0.6	0.9	1.4	-0.9	-0.9	0.9	1.2
Social response proportion	0.6	0.6	0.7	0.7	0.8	-0.8	-0.8
Social responses	0.4	0.5	0.7	0.7	0.7	-0.7	-0.8
Social time	0.3	0.4	0.5	-0.6	-0.7	0.7	0.7
Conditioned locomotion	2.9	3.4	3.7	-1.9	-1.9	1.9	1.8
Cocaine response after cond. corrected	0.2	0.3	0.4	0.4	0.5	-0.5	-0.6
Cocaine response after cond. not corrected	1.9	2.1	2.3	1.4	1.4	-1.4	-1.5
Cocaine response before conditioning	1.2	1.5	1.8	1.4	1.2	-1.2	-1.2
Saline control response	1.5	2.0	2.4	1.4	1.4	-1.4	-1.6
Condit. Reinf. active minus inactive responses	2.1	2.6	2.7	1.7	1.6	-1.6	-1.6
Condit. Reinf. active-inactive response ratio	1.8	1.9	1.9	1.4	1.3	-1.3	-1.4
Condit. Reinf. active responses	1.9	2.7	2.9	1.7	1.6	-1.6	-1.7
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0
Condit. Reinf. lever presses	2.4	3.3	3.7	1.9	1.8	-1.8	-1.7
Condit. Reinf. lever reinforcers received	2.1	2.9	3.2	1.7	1.7	-1.7	-1.8
Pavlov. Cond. lever latency	0.3	0.5	0.5	-0.7	-0.7	0.7	0.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.3	-0.4	0.4	0.6
Pavlov. Cond. change in total contacts	2.2	3.0	3.2	1.8	1.7	-1.7	-1.7
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	0.2	-0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	0.2	-0.2	0.0
Pavlov. Cond. lever contacts	0.9	1.2	1.4	1.2	1.1	-1.1	-1.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.6	0.7	-0.7	-0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.9	-0.9	-0.7	0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.3	0.2	-0.2	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1
Conditioned reinforcement - actives	0.4	0.4	0.5	-0.6	-0.7	0.7	0.5
Conditioned reinforcement - inactives	1.0	1.2	1.3	-1.1	-1.0	1.0	1.2
Conditioned locomotion	0.3	0.4	0.5	-0.5	-0.7	0.7	0.4
Intermittent access intake day 1-15 change	0.6	0.6	0.7	-0.7	-0.8	0.8	0.8
Intermittent access intake escalation	0.6	0.6	0.6	-0.8	-0.7	0.7	0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	-0.9	-0.8	0.8	0.7
Intermitt. access escalation Index	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1
Intermittent access day 15 total infusions	0.4	0.4	0.5	-0.7	-0.7	0.7	0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.2	-0.5	-0.5	0.5	0.2
Intermittent access total infusions	0.5	0.5	0.6	-0.8	-0.8	0.8	0.5
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.4	-0.4	0.4	0.1
Intermittent access day 15 total locomotion	0.7	0.8	1.0	-0.9	-0.8	0.8	1.0
Intermittent access total locomotion	1.1	1.2	1.4	-1.1	-1.2	1.2	1.0
Intermittent access standard deviation	0.1	0.1	0.1	0.4	0.4	-0.4	-0.4
Cocaine induced anxiety	0.3	0.4	0.5	-0.7	-0.7	0.7	0.0
Post-drug Anxiety	0.1	0.1	0.2	-0.4	-0.4	0.4	0.1
Baseline Anxiety	0.4	0.4	1.0	-0.6	-0.5	0.4	1.0
Lifetime Intake	0.4	0.4	0.5	-0.6	-0.7	0.7	0.6
Incentive Sensitization - Responses	1.6	1.6	1.8	-1.3	-1.3	1.3	1.1
Incentive Sensitization - Breakpoint	1.6	1.6	1.7	-1.3	-1.3	1.3	1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	-0.2	0.2	0.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.5	-0.7	-0.7	0.7	0.6
Progressive ratio test 2 active lever presses	0.9	1.0	1.1	-1.0	-1.1	1.1	0.7
Progressive ratio test 2 breakpoint	0.6	0.7	0.9	-0.8	-0.9	0.9	0.6
Progressive ratio test 2 inactive lever presses	1.9	2.2	2.6	-1.6	-1.6	1.6	1.2
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	-0.3	0.3	0.4
Short access day 1 total inactive lever presses	4.9	5.5	7.1	-2.2	-2.2	2.2	2.7
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.2
Short access day 1 total infusions	1.0	1.1	1.2	-1.0	-1.0	1.0	1.1
Short access day 10 total infusions	0.1	0.1	0.1	-0.2	-0.3	0.3	0.3
Short access total infusions	0.7	0.7	0.9	-0.8	-0.8	0.8	1.0
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.2	0.2	0.2
Short access day 10 total locomotion	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1
Short access total locomotion	0.0	0.0	0.0	0.0	-0.1	0.1	-0.1
Compulsive drug intake	0.1	0.1	0.3	-0.2	-0.1	0.1	0.5
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5
One hour access (shock baseline)	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1
Number of responses in last shaping day	0.8	0.8	1.0	-1.0	-0.9	0.9	0.7
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Locomotion velocity, session 1	0.1	0.1	0.1	-0.2	-0.3	0.3	0.2
Locomotion distance, session 1	0.8	1.1	1.4	1.2	1.0	-1.0	-1.0
Locomotion velocity, session 2	0.3	0.3	0.3	-0.5	-0.6	0.6	0.6
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	-0.2	0.2	0.2
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3
Locomotion distance, session 3	1.0	1.1	1.3	-0.9	-1.1	1.1	1.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	0.2	-0.2	-0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.3	0.5	-0.5	-0.5
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	0.5	-0.5	-0.3
Locomotion distance, session 7	0.8	1.0	1.3	-1.1	-0.9	0.9	1.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.1	-0.2	0.2	0.2
Stereotopy head waving duration, day 7	0.3	0.3	0.4	0.7	0.6	-0.6	-0.5
Locomotion velocity, session 8	0.2	0.2	0.3	0.6	0.4	-0.4	-0.4
Locomotion distance, session 8	0.2	0.3	0.4	0.6	0.5	-0.5	-0.4
Degree of sensitization distance	1.1	1.1	1.3	0.9	1.1	-1.1	-1.1
Degree of sensitization stereotypy	0.1	0.1	0.1	0.3	0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	0.4	0.5	-0.5	-0.6
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	-0.1	0.1	0.2
Condit. Reinf. inactive responses	0.6	0.7	1.0	-0.8	-0.8	0.8	1.0
Incentive salience index mean	0.0	0.1	0.1	-0.2	-0.3	0.3	0.2
Condit. Reinf. lever presses	1.5	2.0	2.2	-1.3	-1.5	1.5	1.4
Time in familiar zone, hab. session 1	1.7	1.6	2.0	-1.4	-1.2	1.2	1.2
Time in novel zone, hab. session 1	0.9	0.9	1.1	1.0	0.9	-0.9	-1.0
Total zone transitions, hab. session 1	0.6	0.8	1.0	1.0	0.9	-0.9	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.8	0.6	-0.6	-0.6
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.8	0.6	-0.6	-0.6
Time in familiar zone, hab. session 2	0.7	0.8	0.8	-0.9	-0.8	0.8	0.9
Time in novel zone, hab. session 2	0.0	0.1	0.1	0.2	0.2	-0.2	-0.3
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.4	0.2	-0.2	-0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.8	0.6	-0.6	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.7	0.5	-0.5	-0.4
Novel to familiar place preference ratio	0.7	0.7	0.8	0.9	0.9	-0.9	-0.7
Novelty place preference	0.7	0.7	0.8	0.9	0.9	-0.9	-0.7
Time in novel zone, NPP test	0.9	1.0	1.1	1.0	1.0	-1.0	-0.9
Total zone transitions, NPP test	2.3	3.2	4.3	2.1	1.7	-1.7	-1.6
Total locomotion distance, NPP test	1.1	1.5	2.1	1.5	1.2	-1.2	-1.1
Locomotion velocity, NPP test	1.2	1.7	2.3	1.5	1.2	-1.2	-1.1
Pavlov. Cond. lever latency	5.2	6.6	7.1	2.4	2.7	-2.7	-2.6
Pavlov. Cond. magazine entry latency	6.7	8.7	9.1	-2.9	-3.0	3.0	2.8
Pavlov. Cond. change in total contacts	1.9	2.0	2.1	-1.4	-1.4	1.4	1.3
Pavlov. Cond. index score	6.6	8.5	8.9	-2.8	-3.0	3.0	2.8
Pavlov. Cond. latency score	6.4	8.2	8.7	-2.8	-3.0	3.0	2.8
Pavlov. Cond. lever contacts	2.9	3.5	3.9	-1.7	-2.0	2.0	1.8
Pavlov. Cond. magazine entry number	7.8	9.8	10.1	3.1	3.2	-3.2	-3.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.5	0.7	-0.7	-0.4
Pavlov. Cond. lever-magazine prob. diff.	5.9	7.4	7.9	-2.7	-2.8	2.8	2.6
Pavlov. Cond. response bias	7.2	8.9	9.3	-2.9	-3.0	3.0	2.9
Bone: apparent density	0.0	0.0	0.0	0.2	0.2	-0.2	0.1
Bone surface	0.1	0.1	0.2	-0.2	-0.3	0.3	0.5
Bone volume	0.0	0.0	0.1	-0.0	-0.1	0.1	0.4
Bone: connectivity density	0.2	0.3	0.3	-0.5	-0.5	0.5	0.6
Bone: cortical apparent density	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5
Bone: cortical area	0.2	0.3	0.3	-0.6	-0.5	0.5	0.5
Bone: cortical porosity	0.0	0.0	0.1	-0.3	-0.2	0.2	0.1
Bone: cortical porosity	0.2	0.2	0.3	-0.6	-0.4	0.4	0.3
Bone: cortical thickness	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2
Bone: cortical thickness	0.0	0.0	0.0	0.0	0.0	-0.0	0.1
Bone: cortical tissue density	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5
Bone: elastic displacement	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1
Bone: elastic work	0.4	0.5	0.7	0.8	0.7	-0.7	-0.5
Bone: endosteal estimation	0.0	0.1	0.1	0.1	0.3	-0.3	-0.3
Bone: endosteal perimeter	1.2	2.4	2.5	-1.6	-1.6	1.6	1.5
Bone: final force	0.8	1.3	1.3	1.1	1.2	-1.2	-1.1
Bone: final moment	1.0	1.7	1.7	1.2	1.3	-1.3	-1.3
Bone: marrow area	0.0	0.1	0.1	0.1	0.4	-0.4	-0.3
Bone: maximum diameter	0.4	0.8	0.8	-0.9	-0.9	0.9	0.8
Bone: maximum force	0.6	1.1	1.2	0.9	1.1	-1.1	-1.0
Bone: maximum moment	0.7	1.2	1.3	1.0	1.2	-1.2	-1.1
Bone: minimum diameter	0.5	0.9	1.0	-1.0	-0.9	0.9	1.0
Bone: periosteal estimation	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0
Bone: periosteal perimeter	1.3	2.1	2.2	-1.5	-1.5	1.5	1.4
Bone: post-yield work	0.0	0.0	0.0	0.1	0.2	-0.2	-0.1
Bone: stiffness	0.1	0.2	0.2	0.3	0.5	-0.5	-0.5
Bone: tissue strength	2.8	2.7	2.9	1.6	1.7	-1.7	-1.6
Bone: trabecular number	0.6	1.0	1.3	-0.9	-0.9	0.9	1.1
Bone: trabecular spacing	1.4	1.8	1.9	1.2	1.4	-1.4	-1.4
Bone: trabecular thickness	0.0	0.0	0.1	0.4	0.2	-0.2	0.0
Bone: trabecular tissue density	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.1	0.3	-0.3	-0.5
Distance traveled before self-admin	0.0	0.0	0.1	-0.2	0.0	-0.0	0.2
Distance traveled after self-admin	0.3	0.3	0.4	-0.7	-0.5	0.5	0.5
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.4	-0.4	0.4	0.7
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.4	0.5	-0.5	-0.4
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.1
Active lever presses in extinction session 6	0.3	0.3	0.5	0.4	0.5	-0.5	-0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.1	-0.4	-0.4	0.4	0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	0.4	0.5	-0.5	-0.7
Time in closed arm before self-admin	1.6	1.8	2.1	1.4	1.3	-1.3	-1.3
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.1	-0.1	0.1
Time in open arm before self-admin	1.2	1.3	1.5	-1.2	-1.1	1.1	1.1
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	-0.4	0.4	0.5
Sum of active levers in priming session hrs 5-6	0.7	0.6	0.8	0.8	0.7	-0.7	-0.9
Time to tail flick, vehicle, before self-admin	2.0	2.0	2.1	1.4	1.4	-1.4	-1.5
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.3	1.0	0.8	-0.8	-1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.5	0.3	-0.3	-0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	-0.6	-0.7	0.7	0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	-0.7	-0.6	0.6	0.4
Ambulatory time before self-admin	0.2	0.2	0.3	-0.4	-0.3	0.3	0.5
Ambulatory time after self-admin	0.0	0.1	0.1	-0.4	-0.1	0.1	0.2
Total heroin consumption	1.0	1.2	1.4	1.0	1.2	-1.2	-1.1
Area under the delay curve	2.0	2.1	2.3	-1.5	-1.5	1.5	1.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.2	-0.2	0.2	0.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.0	-1.0	-1.0	1.0	0.9
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	-0.6	-0.5	0.5	0.3
Delay disc. indifference point, 24s delay	0.8	0.8	0.8	-0.9	-0.9	0.9	0.9
Delay disc. indifference point, 4s delay	2.0	2.1	2.4	-1.6	-1.5	1.5	1.2
Delay disc. indifference point, 8s delay	2.0	2.1	2.3	-1.5	-1.5	1.5	1.3
Delay discount exponential model param	2.3	2.5	2.8	1.7	1.6	-1.6	-1.4
Delay discount hyperbolic model param	2.3	2.4	2.7	1.7	1.6	-1.6	-1.4
Fecal boli incidents, locomotor time 1	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.2	-0.3	0.3	0.6
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Rest time, locomotor task time 1	0.7	0.8	0.9	-0.9	-0.8	0.8	1.0
Distance moved, locomotor task time 1	1.8	2.0	2.3	1.5	1.4	-1.4	-1.3
Vertical activity count, locomotor time 1	1.0	1.1	1.3	1.1	1.0	-1.0	-1.0
Time >=10cm from walls, locomotor time 2	1.4	1.5	1.7	1.3	1.3	-1.3	-1.1
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.0	0.0	0.0
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	-0.3	0.3	0.3
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.2	0.2	0.3
Distance moved, locomotor task time 2	1.2	1.4	2.0	1.4	1.1	-1.1	-1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.5	0.3	-0.3	-0.2
Weight adjusted by age	0.3	0.4	0.7	0.5	0.5	-0.5	-0.8
Seeking ratio, delayed vs. immediate footshock	2.9	3.3	3.6	-1.9	-1.8	1.8	1.7
Locomotion in novel chamber	0.2	0.2	0.2	-0.4	-0.5	0.5	0.4
Locomotion in novel chamber post-restriction	0.7	0.8	1.1	1.0	0.9	-0.9	-0.6
Progressive ratio	3.4	3.9	4.0	1.9	2.0	-2.0	-2.0
Food seeking constrained by brief footshock	0.8	1.0	1.4	-0.7	-1.0	1.0	1.2
Seeking ratio, punishment vs. effort	5.3	6.6	7.2	-2.4	-2.6	2.6	2.7
Run reversals in cocaine runway, females	1.9	1.9	2.9	-1.2	-1.3	1.3	1.7
Run reversals in cocaine runway, males	0.8	0.8	1.1	0.8	0.8	-0.8	-1.1
Latency to leave start box in cocaine runway	0.5	0.5	0.7	0.8	0.6	-0.6	-0.8
Latency to leave start box in cocaine runway, F	1.4	1.6	1.9	1.4	1.2	-1.2	-1.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.4	-0.5	0.5	0.3
Cd content in liver	2.4	2.6	3.5	1.4	1.6	-1.6	-1.9
Co content in liver	0.0	0.0	0.0	-0.2	-0.0	0.0	0.1
Cu content in liver	4.0	4.8	5.3	2.1	2.2	-2.2	-2.3
Fe content in liver	1.6	1.9	2.4	1.2	1.4	-1.4	-1.6
K content in liver	0.8	0.8	1.1	1.0	0.9	-0.9	-0.8
Mg content in liver	0.0	0.0	0.0	0.2	0.0	0.0	0.1
Mn content in liver	0.6	0.7	0.9	1.0	0.8	-0.8	-0.7
Na content in liver	0.4	0.4	0.5	0.5	0.6	-0.6	-0.7
Rb content in liver	0.9	1.1	1.6	0.6	1.1	-1.1	-1.2
Se content in liver	0.1	0.1	0.2	0.4	0.3	-0.3	0.0
Sr content in liver	0.0	0.0	0.1	0.3	0.1	-0.1	0.2
Zn content in liver	4.4	4.9	5.4	2.3	2.2	-2.2	-2.2