Hub : Genes

Srp19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000020204 0.07 0.05 1.0e-05 0.04 0.03 0.03 0.03 2.3e-05 1.1e-04 2.5e-04 1.0e-04
2 Liver gene expression ENSRNOG00000020204 0.04 0.03 8.1e-04 0.02 0.02 0 0.01 6.4e-03 3.9e-03 1.5e-01 2.1e-02
3 Liver intron excision ratio chr18:25931783:25935915 0.03 0.02 3.3e-04 0.02 0.02 0.01 0.02 3.0e-03 1.8e-03 1.4e-02 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail7.223.425.34.55.0-5.0
BMI without tail5.311.012.83.13.3-3.6
Body weight7.230.536.24.96.0-5.6
Epididymis fat weight4.09.311.23.32.4-3.3
Glucose7.912.112.73.43.4-3.6
Heart weight4.05.78.91.83.0-2.2
Left kidney weight0.20.61.30.21.1-0.7
Right kidney weight0.10.20.6-0.00.8-0.3
Tail length0.10.20.30.20.3-0.6
Length with tail0.93.24.51.52.1-1.7
Length without tail0.91.92.81.21.7-1.1
Liver weight, left0.10.20.40.0-0.60.3
Liver weight, right1.83.05.0-1.3-2.21.5
Parametrial fat weight0.91.73.11.80.3-1.4
Retroperitoneal fat weight3.913.014.53.83.3-3.7
Intraocular pressure5.17.28.22.42.9-2.7
Extensor digitorum longus weight2.18.58.72.92.9-3.0
Soleus weight1.54.47.42.71.4-2.0
Tibialis anterior weight0.93.13.71.51.9-1.9
Tibia length1.23.25.01.22.2-1.8
Number of licking bursts1.61.92.5-1.6-1.11.4
Food consumed during 24 hour testing period1.51.83.30.81.8-1.3
Times rat made contact with spout0.40.40.8-0.40.9-0.6
Mean time between licks in bursts0.20.30.70.00.8-0.6
Mean num. licks in bursts2.12.63.11.31.7-1.8
Std. dev. time between licks in bursts0.00.00.0-0.2-0.00.2
Water consumed over 24 hours0.50.51.0-0.81.0-0.1
Indifference point 0 sec2.94.75.6-2.1-2.42.1
Indifference point AUC3.33.84.6-1.9-1.82.1
Indifference point function ln k8.011.412.63.43.2-3.5
Indifference point function log k8.011.412.63.43.2-3.5
Delay discounting total patch changes 0 sec3.04.85.6-2.1-2.42.1
Delay discounting total patch changes 12 sec11.415.215.6-4.0-3.93.9
Delay discounting total patch changes 18 sec4.66.18.1-2.9-2.02.5
Delay discounting total patch changes 24 sec3.54.45.1-2.3-1.92.1
Delay discounting total patch changes 6 sec4.56.87.4-2.7-2.52.6
Delay discounting time to switch 0 sec0.10.20.30.40.3-0.6
Delay discounting water rate 0 sec0.00.00.0-0.2-0.00.0
Delay discounting water rate 12 sec0.50.81.30.31.1-1.0
Delay discounting water rate 18 sec0.10.10.20.3-0.0-0.5
Delay discounting water rate 24 sec0.10.10.30.10.1-0.6
Delay discounting water rate 6 sec0.10.10.1-0.10.4-0.4
Locomotor activity0.10.10.3-0.10.60.1
Locomotor testing distance0.10.10.30.00.6-0.0
Locomotor testing rearing0.60.91.2-1.1-0.80.9
Light reinforcement 11.93.54.3-2.1-1.91.6
Light reinforcement 22.73.63.9-2.0-1.71.9
Reaction time number correct1.42.02.71.11.7-1.5
Reaction time mean minus median0.10.10.2-0.40.20.2
Reaction time mean minus median AUC0.30.30.60.10.8-0.6
Reaction time num false alarms1.11.62.21.50.9-1.3
Reaction time num false alarms AUC1.82.53.51.91.1-1.7
Reaction time trials correct on left1.42.02.71.11.7-1.5
Reaction time trials on left1.52.12.81.11.7-1.5
Reaction time mean0.81.01.21.11.0-1.0
Reaction time mean AUC0.40.60.80.90.6-0.8
Median of all reaction times1.31.82.61.61.0-1.3
Reaction time omissions0.00.00.0-0.1-0.20.0
Reaction time false alarm rate0.50.71.51.20.3-0.8
Reaction time premature initiation rate3.54.76.6-2.6-1.62.3
Reaction time premature initiations1.52.23.5-1.9-1.01.5
Std. dev. reaction times0.81.12.00.51.4-1.0
Reaction time trials completed1.52.12.81.11.7-1.5
Reaction time trials AUC1.52.12.91.11.7-1.5
Social response proportion1.01.12.01.40.6-1.0
Social responses0.81.02.3-0.2-1.50.9
Social time0.30.30.50.7-0.6-0.4
Conditioned locomotion0.10.10.3-0.30.5-0.1
Cocaine response after cond. corrected0.60.71.20.50.7-1.1
Cocaine response after cond. not corrected0.10.10.2-0.3-0.4-0.1
Cocaine response before conditioning6.47.89.0-2.5-3.02.8
Saline control response1.01.41.4-1.1-1.21.2
Condit. Reinf. active minus inactive responses4.15.16.8-2.0-2.62.1
Condit. Reinf. active-inactive response ratio0.00.00.10.3-0.2-0.2
Condit. Reinf. active responses10.214.217.7-3.4-4.23.6
Condit. Reinf. inactive responses11.213.916.0-3.5-4.03.7
Condit. Reinf. lever presses2.73.73.9-2.0-2.01.9
Condit. Reinf. lever reinforcers received9.513.317.2-3.2-4.13.5
Pavlov. Cond. lever latency1.41.92.41.31.5-1.3
Pavlov. Cond. magazine entry latency0.10.10.2-0.3-0.40.3
Pavlov. Cond. change in total contacts1.82.53.2-1.2-1.81.6
Pavlov. Cond. index score0.81.01.5-0.8-1.21.0
Pavlov. Cond. latency score0.70.91.4-0.6-1.21.0
Pavlov. Cond. lever contacts1.72.33.0-1.5-1.71.3
Pavlov. Cond. magazine entry number1.41.72.41.01.6-1.3
Pavlov. Cond. intertrial magazine entries0.20.20.5-0.10.7-0.2
Pavlov. Cond. lever-magazine prob. diff.0.81.01.5-0.8-1.21.0
Pavlov. Cond. response bias2.63.64.4-1.8-2.11.8
Conditioned reinforcement - actives0.10.10.30.2-0.6-0.0
Conditioned reinforcement - inactives0.10.10.3-0.5-0.20.2
Conditioned locomotion0.30.30.5-0.6-0.70.4
Intermittent access intake day 1-15 change0.20.20.20.40.4-0.4
Intermittent access intake escalation0.00.00.10.10.2-0.2
Intermittent access intake escalation 20.20.20.40.40.7-0.4
Intermitt. access day 1 inactive lever presses0.00.00.1-0.3-0.10.2
Intermitt. access day 15 inactive lever presses0.10.10.2-0.5-0.1-0.2
Intermitt. access escalation Index1.10.91.01.01.0-0.9
Intermittent access day 1 total infusions1.01.22.6-0.7-1.60.7
Intermittent access day 15 total infusions0.80.91.9-0.7-1.40.5
Intermittent access terminal intake (last 3 days)0.50.61.3-0.5-1.10.4
Intermittent access total infusions0.30.41.1-0.2-1.10.1
Intermittent access day 1 locomotion0.40.41.1-0.0-1.10.1
Intermittent access day 15 total locomotion1.11.21.91.10.8-1.4
Intermittent access total locomotion0.50.61.01.00.0-0.9
Intermittent access standard deviation0.20.20.50.7-0.2-0.0
Cocaine induced anxiety0.30.30.40.60.6-0.4
Post-drug Anxiety0.20.20.4-0.30.20.6
Baseline Anxiety0.50.60.8-0.9-0.40.9
Lifetime Intake0.40.51.4-0.0-1.2-0.1
Incentive Sensitization - Responses0.00.00.10.10.2-0.3
Incentive Sensitization - Breakpoint0.10.10.10.10.3-0.4
Progressive ratio test 1 active lever presses0.10.10.20.1-0.4-0.3
Progressive ratio test 1 breakpoint0.10.10.20.1-0.5-0.3
Progressive ratio test 1 inactive lever presses0.60.71.6-0.5-1.30.4
Progressive ratio test 2 active lever presses0.10.20.30.2-0.4-0.5
Progressive ratio test 2 breakpoint0.20.20.40.4-0.1-0.7
Progressive ratio test 2 inactive lever presses0.20.20.50.2-0.7-0.1
Total sessions with >9 infusions1.01.01.81.30.4-1.1
Short access day 1 total inactive lever presses0.80.91.5-0.9-1.20.6
Short access day 10 total inactive lever presses0.50.61.2-1.1-0.20.7
Short access day 1 total infusions0.60.71.60.5-1.2-0.4
Short access day 10 total infusions0.10.10.3-0.2-0.50.2
Short access total infusions0.60.72.1-0.1-1.50.2
Short access day 1 locomotion1.41.52.31.40.6-1.5
Short access day 10 total locomotion2.32.53.82.01.4-1.3
Short access total locomotion0.80.81.71.30.2-0.9
Compulsive drug intake1.01.01.20.91.0-1.1
One hour access (0.3 mA shock)0.20.20.30.5-0.4-0.5
One hour access (shock baseline)0.30.41.0-0.2-1.00.3
Number of responses in last shaping day1.61.62.6-1.3-1.60.8
Context. condit. distance diff. score0.00.00.1-0.3-0.1-0.1
Locomotion velocity, session 10.40.40.70.80.5-0.6
Locomotion distance, session 10.00.00.0-0.0-0.1-0.1
Locomotion velocity, session 20.50.60.90.90.6-0.7
Locomotion distance, session 20.60.91.0-0.9-1.00.9
Locomotion velocity, session 30.30.30.60.40.4-0.7
Locomotion distance, session 30.10.10.3-0.6-0.00.0
Stereotopy head waving bouts, day 32.02.42.7-1.4-1.61.7
Stereotopy head waving duration, day 30.20.20.40.2-0.70.3
Locomotion velocity, session 70.50.51.20.31.1-0.6
Locomotion distance, session 70.20.20.4-0.70.30.4
Stereotopy head waving bouts, day 70.50.61.31.20.4-0.6
Stereotopy head waving duration, day 70.10.20.50.7-0.2-0.2
Locomotion velocity, session 80.20.30.50.7-0.3-0.5
Locomotion distance, session 80.10.10.2-0.3-0.40.0
Degree of sensitization distance0.20.20.50.40.7-0.2
Degree of sensitization stereotypy0.20.30.70.8-0.0-0.2
Condit. Reinf. active minus inactive responses2.12.42.5-1.5-1.61.6
Condit. Reinf. active-inactive response ratio1.11.21.3-1.2-1.01.1
Condit. Reinf. active responses2.42.93.3-1.8-1.71.6
Condit. Reinf. inactive responses1.51.72.3-1.5-1.21.2
Incentive salience index mean1.92.32.8-1.3-1.71.6
Condit. Reinf. lever presses1.31.82.1-1.1-1.51.4
Time in familiar zone, hab. session 10.40.30.80.20.9-0.4
Time in novel zone, hab. session 11.00.91.2-0.8-1.11.0
Total zone transitions, hab. session 12.33.23.41.81.8-1.7
Total locomotion distance, hab. session 10.00.10.10.30.2-0.2
Locomotion velocity, hab. session 10.00.10.10.40.0-0.2
Time in familiar zone, hab. session 23.84.05.9-2.4-1.71.8
Time in novel zone, hab. session 23.43.45.02.21.5-1.7
Total zone transitions, hab. session 20.10.10.20.30.2-0.4
Total locomotion distance, hab. session 20.40.50.7-0.8-0.70.4
Locomotion velocity, hab. session 20.10.10.2-0.5-0.40.1
Novel to familiar place preference ratio2.93.03.31.81.8-1.6
Novelty place preference3.43.54.02.01.9-1.7
Time in novel zone, NPP test2.93.13.41.81.8-1.6
Total zone transitions, NPP test0.00.00.1-0.1-0.20.1
Total locomotion distance, NPP test0.50.80.9-0.9-1.00.7
Locomotion velocity, NPP test0.71.01.2-1.0-1.10.9
Pavlov. Cond. lever latency0.00.00.0-0.10.1-0.1
Pavlov. Cond. magazine entry latency0.20.30.5-0.4-0.40.7
Pavlov. Cond. change in total contacts0.00.00.10.10.20.3
Pavlov. Cond. index score0.00.00.10.1-0.10.3
Pavlov. Cond. latency score0.00.10.10.40.00.1
Pavlov. Cond. lever contacts0.20.20.4-0.1-0.60.6
Pavlov. Cond. magazine entry number0.10.10.30.30.2-0.5
Pavlov. Cond. intertrial magazine entries0.10.20.3-0.6-0.20.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.1-0.20.4
Pavlov. Cond. response bias0.20.20.4-0.4-0.30.6
Bone: apparent density0.30.40.9-1.00.10.6
Bone surface0.71.22.4-1.5-0.41.1
Bone volume0.50.81.8-1.3-0.20.8
Bone: connectivity density1.42.23.2-1.8-1.01.5
Bone: cortical apparent density1.21.62.0-0.9-1.41.4
Bone: cortical area2.94.46.1-2.5-1.62.1
Bone: cortical porosity0.80.91.11.00.8-1.0
Bone: cortical porosity0.60.60.80.90.7-0.8
Bone: cortical thickness2.13.45.0-2.2-1.22.0
Bone: cortical thickness0.30.40.9-0.9-0.20.6
Bone: cortical tissue density1.01.31.8-0.7-1.31.2
Bone: elastic displacement1.11.31.71.30.7-1.3
Bone: elastic work1.41.82.41.50.9-1.5
Bone: endosteal estimation0.71.41.7-1.3-1.21.1
Bone: endosteal perimeter0.10.20.3-0.5-0.60.5
Bone: final force1.21.92.4-1.6-1.11.5
Bone: final moment0.71.21.5-1.2-0.91.1
Bone: marrow area0.61.41.7-1.3-1.11.1
Bone: maximum diameter2.85.26.3-2.5-2.12.2
Bone: maximum force0.40.60.9-1.0-0.40.9
Bone: maximum moment0.10.20.3-0.6-0.20.5
Bone: minimum diameter0.91.62.4-1.6-0.91.3
Bone: periosteal estimation1.63.24.4-2.1-1.51.8
Bone: periosteal perimeter1.01.61.7-1.3-1.21.2
Bone: post-yield work0.20.20.3-0.5-0.30.5
Bone: stiffness0.81.21.8-1.3-0.71.2
Bone: tissue strength0.10.10.10.10.3-0.2
Bone: trabecular number0.20.30.7-0.80.10.4
Bone: trabecular spacing0.10.10.2-0.2-0.50.3
Bone: trabecular thickness0.30.30.7-0.8-0.20.6
Bone: trabecular tissue density0.20.20.40.40.6-0.3
Breakpoint value in progressive ratio session0.00.00.00.20.2-0.2
Distance traveled before self-admin0.10.10.20.00.4-0.1
Distance traveled after self-admin0.60.71.4-0.6-1.20.6
Delta time in closed arm before/after self-admin2.52.43.71.91.0-1.6
Delta time in open arm before/after self-admin0.80.81.2-1.10.31.0
Diff in mean of infusions in LGA sessions0.91.01.60.71.0-1.3
Extinction: sum of active levers before priming0.30.30.50.40.7-0.4
Active lever presses in extinction session 62.12.12.7-1.6-1.21.4
Delta distance traveled before/after self-admin3.23.45.7-1.8-2.41.1
Delta ambulatory time before/after self-admin2.62.94.4-1.7-2.11.1
Time in closed arm before self-admin1.01.22.50.41.6-0.9
Time in closed arm after self-admin1.41.41.61.11.3-1.2
Time in open arm before self-admin0.40.41.20.1-1.10.0
Time in open arm after self-admin0.40.40.7-0.80.00.7
Sum of active levers in priming session hrs 5-61.91.92.6-1.2-1.61.2
Time to tail flick, vehicle, before self-admin2.02.02.6-1.4-1.11.6
Time to tail flick, vehicle, after self-admin0.10.10.20.0-0.20.4
Time to tail flick, test, before self-admin0.20.20.20.50.4-0.3
Time to tail flick, test, after self-admin1.31.42.5-0.8-1.61.0
Delta time to tail flick, vehicle, before/after SA0.30.30.40.60.3-0.6
Delta time to tail flick, test, before/after SA0.40.40.9-0.1-1.00.4
Ambulatory time before self-admin0.10.10.40.10.6-0.2
Ambulatory time after self-admin0.50.60.8-0.9-0.90.5
Total heroin consumption0.20.20.30.60.1-0.5
Area under the delay curve3.74.05.1-2.3-1.91.8
Delay disc. indifference point, 0s delay1.21.31.8-1.3-0.91.1
Delay disc. indifference point, 16s delay5.05.06.1-2.5-2.12.2
Delay disc. indifference point, 2s delay0.30.30.5-0.7-0.30.5
Delay disc. indifference point, 24s delay0.60.61.2-1.1-0.60.5
Delay disc. indifference point, 4s delay0.40.40.6-0.8-0.50.7
Delay disc. indifference point, 8s delay5.25.47.2-2.7-2.22.0
Delay discount exponential model param3.84.05.32.31.8-1.9
Delay discount hyperbolic model param3.43.64.82.21.7-1.8
Fecal boli incidents, locomotor time 10.10.20.30.5-0.4-0.3
Change in fecal boli incidents, locomotor task0.10.10.10.2-0.3-0.2
Time >=10cm from walls, locomotor time 10.40.40.80.30.6-0.9
Bouts of movement, locomotor time 11.92.13.2-1.8-1.41.0
Total resting periods, locomotor time 11.71.92.9-1.7-1.40.9
Rest time, locomotor task time 10.10.10.1-0.30.2-0.3
Distance moved, locomotor task time 10.20.20.30.30.60.4
Vertical activity count, locomotor time 11.21.32.61.01.6-0.3
Time >=10cm from walls, locomotor time 26.16.57.42.72.7-2.2
Bouts of movement, locomotor time 20.50.60.8-0.9-0.70.6
Total resting periods, locomotor time 20.20.30.5-0.7-0.40.3
Rest time, locomotor task time 21.41.72.40.81.4-1.6
Distance moved, locomotor task time 20.20.20.5-0.00.50.7
Vertical activity count, locomotor time 20.30.30.5-0.20.50.7
Weight adjusted by age2.02.22.81.71.4-1.3
Seeking ratio, delayed vs. immediate footshock0.81.01.3-0.7-1.11.1
Locomotion in novel chamber0.20.20.50.2-0.7-0.2
Locomotion in novel chamber post-restriction0.00.00.1-0.20.30.0
Progressive ratio0.10.20.20.4-0.5-0.2
Food seeking constrained by brief footshock0.10.10.1-0.1-0.30.4
Seeking ratio, punishment vs. effort0.10.20.3-0.60.20.4
Run reversals in cocaine runway, females0.40.40.4-0.6-0.70.7
Run reversals in cocaine runway, males0.10.10.20.1-0.40.2
Latency to leave start box in cocaine runway1.51.72.3-1.5-1.11.3
Latency to leave start box in cocaine runway, F1.31.52.3-1.5-0.71.3
Latency to leave start box in cocaine runway, M0.10.10.10.2-0.2-0.3
Cd content in liver0.10.10.3-0.1-0.50.2
Co content in liver0.20.30.40.50.6-0.4
Cu content in liver4.35.25.5-2.2-2.32.3
Fe content in liver1.01.22.0-1.4-0.41.2
K content in liver0.60.61.2-0.3-1.10.8
Mg content in liver2.42.53.7-1.3-1.91.4
Mn content in liver0.20.20.30.40.3-0.5
Na content in liver0.00.00.00.1-0.00.2
Rb content in liver3.24.14.6-1.9-2.12.0
Se content in liver0.30.40.6-0.7-0.30.8
Sr content in liver0.50.50.6-0.5-0.70.8
Zn content in liver2.42.72.8-1.6-1.61.7