Hub : Genes

Pcp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000000993	0.12	0.06	3.1e-08	0.1	0.08	0.08	0.09	1.8e-09	4.1e-08	5.0e-08	1.6e-08
2	Brain	intron excision ratio	chr12:1683275:1683377	0.03	0.02	7.5e-03	0.01	0.01	0	0.01	2.7e-02	3.4e-02	1.6e-01	8.6e-02
3	Brain	intron excision ratio	chr12:1683275:1683586	0.05	0.03	4.1e-03	0.02	0.03	0.02	0.02	2.4e-03	1.2e-03	3.8e-03	6.8e-03
4	Brain	mRNA stability	ENSRNOG00000000993	0.1	0.05	1.1e-07	0.05	0.07	0.07	0.07	1.8e-05	3.2e-07	3.5e-07	7.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	2.4	7.8	11.5	3.4	-3.0	2.0	-2.5
BMI without tail	4.3	9.1	11.5	3.4	-3.4	2.8	-2.4
Body weight	9.9	41.7	65.8	8.1	-7.0	5.7	-4.5
Epididymis fat weight	0.1	0.2	0.3	0.4	-0.6	-0.1	-0.4
Glucose	0.2	0.3	0.9	0.2	-0.1	0.5	-1.0
Heart weight	0.4	0.6	1.7	-0.3	1.3	0.8	0.4
Left kidney weight	4.8	13.6	21.1	4.6	-4.0	3.8	-1.9
Right kidney weight	4.2	12.0	18.8	4.3	-3.8	3.4	-1.9
Tail length	6.6	19.8	26.0	5.1	-5.1	4.4	-2.9
Length with tail	10.5	38.6	58.1	7.6	-6.8	6.0	-3.9
Length without tail	5.8	12.6	21.9	4.7	-3.6	3.0	-2.5
Liver weight, left	0.4	0.7	1.9	-0.3	0.5	-0.8	1.4
Liver weight, right	0.7	1.2	2.4	1.6	-1.2	0.9	-0.1
Parametrial fat weight	0.0	0.1	0.1	0.3	-0.2	0.3	-0.2
Retroperitoneal fat weight	0.2	0.8	2.4	0.5	-0.6	-0.4	-1.5
Intraocular pressure	0.3	0.4	0.8	0.9	-0.9	0.3	0.2
Extensor digitorum longus weight	3.3	13.4	21.6	4.6	-4.3	3.0	-2.0
Soleus weight	0.4	1.1	2.1	1.4	-1.4	0.5	0.1
Tibialis anterior weight	5.6	19.2	29.1	5.4	-5.1	3.7	-2.9
Tibia length	3.1	8.8	11.9	3.4	-3.2	3.0	-2.1
Number of licking bursts	0.2	0.2	0.7	-0.3	0.1	0.8	0.3
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.3	0.5	-0.2	0.7
Times rat made contact with spout	1.2	1.4	2.0	1.2	-1.1	1.4	-0.9
Mean time between licks in bursts	1.6	2.2	2.7	-1.6	1.6	-1.5	1.2
Mean num. licks in bursts	0.2	0.2	0.4	0.7	-0.4	-0.1	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.2	-0.3	0.1	0.2
Water consumed over 24 hours	0.6	0.7	1.2	0.9	-0.8	1.1	-0.1
Indifference point 0 sec	1.9	3.0	4.5	-1.4	1.5	-1.8	2.1
Indifference point AUC	0.1	0.2	0.4	0.6	-0.2	0.6	0.0
Indifference point function ln k	0.2	0.3	0.6	-0.5	0.6	-0.4	0.8
Indifference point function log k	0.2	0.3	0.6	-0.5	0.6	-0.4	0.8
Delay discounting total patch changes 0 sec	2.7	4.3	6.4	-1.7	1.9	-2.1	2.5
Delay discounting total patch changes 12 sec	0.5	0.7	1.1	-0.5	0.6	-1.0	1.0
Delay discounting total patch changes 18 sec	1.9	2.6	4.0	-1.1	1.6	-1.5	2.0
Delay discounting total patch changes 24 sec	2.4	3.0	5.0	-1.5	1.4	-1.6	2.2
Delay discounting total patch changes 6 sec	1.4	2.1	3.3	-1.1	1.5	-1.4	1.8
Delay discounting time to switch 0 sec	0.4	0.7	2.4	0.2	-0.5	-0.1	-1.6
Delay discounting water rate 0 sec	0.8	1.2	4.3	-0.2	0.6	-0.4	2.1
Delay discounting water rate 12 sec	0.3	0.5	1.4	-0.4	0.5	-0.3	1.2
Delay discounting water rate 18 sec	0.0	0.0	0.1	-0.0	-0.0	0.2	0.3
Delay discounting water rate 24 sec	0.2	0.3	0.4	0.5	-0.4	0.5	0.6
Delay discounting water rate 6 sec	0.4	0.6	1.6	-0.0	0.4	-0.7	1.3
Locomotor activity	1.6	2.6	4.2	2.0	-1.2	2.1	-1.0
Locomotor testing distance	0.1	0.2	0.3	0.5	0.1	0.3	0.6
Locomotor testing rearing	0.9	1.4	1.9	-0.9	1.1	-1.3	1.4
Light reinforcement 1	0.4	0.8	1.5	0.6	-0.9	0.7	-1.2
Light reinforcement 2	0.2	0.2	0.3	-0.5	0.4	-0.3	0.5
Reaction time number correct	0.3	0.5	1.2	-0.3	0.6	-0.2	1.1
Reaction time mean minus median	4.0	5.2	6.7	2.2	-2.6	1.8	-2.4
Reaction time mean minus median AUC	0.4	0.6	1.0	0.5	-1.0	0.5	-0.9
Reaction time num false alarms	0.3	0.4	0.7	0.5	0.1	0.7	-0.8
Reaction time num false alarms AUC	0.1	0.2	0.2	0.5	0.3	0.4	-0.5
Reaction time trials correct on left	0.3	0.5	1.2	-0.3	0.6	-0.2	1.1
Reaction time trials on left	0.3	0.4	1.1	-0.3	0.6	-0.2	1.1
Reaction time mean	0.5	0.6	2.4	0.1	-0.1	0.4	-1.5
Reaction time mean AUC	0.3	0.4	1.7	-0.1	0.1	0.2	-1.3
Median of all reaction times	0.4	0.5	1.0	-0.7	0.8	-0.2	-1.0
Reaction time omissions	0.1	0.2	0.6	0.2	-0.0	0.2	-0.8
Reaction time false alarm rate	0.3	0.5	1.1	0.7	-0.2	0.6	-1.0
Reaction time premature initiation rate	0.4	0.6	0.8	0.6	-0.7	0.8	-0.9
Reaction time premature initiations	0.1	0.2	0.3	0.4	-0.4	0.6	-0.3
Std. dev. reaction times	1.4	2.0	3.4	1.2	-1.4	1.0	-1.8
Reaction time trials completed	0.3	0.4	1.1	-0.3	0.6	-0.2	1.1
Reaction time trials AUC	0.4	0.6	1.4	-0.5	0.8	-0.4	1.2
Social response proportion	8.8	9.5	11.9	3.1	-3.0	3.5	-2.7
Social responses	1.2	1.5	2.4	1.5	-1.1	1.5	-0.7
Social time	0.3	0.3	0.9	-0.9	0.6	-0.1	-0.2
Conditioned locomotion	0.6	0.7	1.3	-0.7	0.5	-1.2	1.0
Cocaine response after cond. corrected	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.5
Cocaine response after cond. not corrected	0.4	0.4	0.6	0.7	-0.6	-0.1	-0.8
Cocaine response before conditioning	0.3	0.3	0.7	0.8	-0.7	0.2	-0.4
Saline control response	0.4	0.6	1.0	0.8	-0.8	1.0	0.3
Condit. Reinf. active minus inactive responses	3.5	4.4	5.6	2.1	-1.9	2.4	-2.0
Condit. Reinf. active-inactive response ratio	2.9	3.0	4.5	1.5	-1.4	2.1	-1.8
Condit. Reinf. active responses	3.2	4.4	5.3	2.3	-2.1	2.1	-1.9
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.7	-0.6	0.2	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.6	0.8	-0.6	0.3	-0.5
Condit. Reinf. lever reinforcers received	2.6	3.6	4.1	2.0	-1.8	2.0	-1.8
Pavlov. Cond. lever latency	0.7	1.0	1.5	-1.0	0.8	-1.0	1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.7	0.4	-0.3	0.5	-1.3
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	0.4	-0.3	0.7	-0.6
Pavlov. Cond. index score	0.3	0.4	1.0	0.5	-0.3	0.6	-1.0
Pavlov. Cond. latency score	0.3	0.4	1.0	0.5	-0.3	0.5	-1.0
Pavlov. Cond. lever contacts	0.4	0.6	1.0	0.8	-0.6	0.5	-1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	0.0	-0.2	-0.3	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	-0.4	0.5	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	0.5	-0.2	0.6	-1.0
Pavlov. Cond. response bias	0.3	0.5	1.1	0.6	-0.4	0.5	-1.0
Conditioned reinforcement - actives	3.0	3.0	4.5	1.9	-1.7	2.1	-0.9
Conditioned reinforcement - inactives	0.2	0.2	0.6	-0.3	0.5	-0.1	0.8
Conditioned locomotion	1.1	1.3	2.0	1.4	-1.3	1.3	-0.4
Intermittent access intake day 1-15 change	0.1	0.1	0.4	0.2	0.1	0.2	0.7
Intermittent access intake escalation	0.1	0.1	0.2	0.4	-0.1	0.3	0.5
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.4	0.5	-0.3	0.8
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.7	-0.8	1.0	-0.5	1.3
Intermitt. access day 15 inactive lever presses	0.4	0.5	0.8	-0.6	0.6	-0.9	0.6
Intermitt. access escalation Index	0.3	0.2	0.3	-0.6	0.5	-0.4	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.1
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.3	0.5	-0.2	0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.4	0.5	-0.4	0.4
Intermittent access total infusions	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2
Intermittent access day 1 locomotion	0.5	0.5	0.7	-0.9	0.8	-0.8	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.1	-0.3	0.4	-0.1	0.4
Intermittent access total locomotion	0.2	0.2	0.4	-0.6	0.7	-0.4	0.1
Intermittent access standard deviation	0.4	0.4	0.8	-0.3	0.5	-0.7	0.9
Cocaine induced anxiety	0.1	0.1	0.3	-0.2	0.1	-0.5	0.0
Post-drug Anxiety	0.2	0.3	0.6	-0.5	0.3	-0.4	-0.8
Baseline Anxiety	0.3	0.3	0.8	-0.5	0.3	-0.1	-0.9
Lifetime Intake	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	0.2	0.1	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.2	0.2	0.1	0.2
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	0.6	-0.4	0.7	-0.3
Progressive ratio test 1 breakpoint	0.5	0.5	0.9	0.7	-0.6	0.9	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.1	0.1	0.4	0.5
Progressive ratio test 2 active lever presses	0.6	0.7	1.4	0.8	-0.7	1.2	-0.4
Progressive ratio test 2 breakpoint	0.5	0.6	1.4	0.6	-0.5	1.2	-0.5
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.5	0.1	0.3	0.2	1.2
Total sessions with >9 infusions	0.2	0.3	0.3	0.6	-0.5	0.4	-0.5
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.3	0.5	-0.3	0.6
Short access day 10 total inactive lever presses	0.2	0.2	0.8	0.3	-0.0	-0.2	0.9
Short access day 1 total infusions	1.0	1.1	1.7	-1.1	1.0	-1.3	0.6
Short access day 10 total infusions	0.4	0.4	0.7	-0.7	0.7	-0.8	0.3
Short access total infusions	0.1	0.1	0.3	-0.0	-0.0	-0.2	-0.6
Short access day 1 locomotion	0.2	0.2	0.6	-0.2	0.1	0.3	-0.8
Short access day 10 total locomotion	1.2	1.3	1.7	-1.1	1.1	-1.3	1.0
Short access total locomotion	0.2	0.2	0.2	-0.5	0.4	-0.5	-0.3
Compulsive drug intake	2.7	2.7	4.2	-2.0	1.9	-1.4	1.1
One hour access (0.3 mA shock)	0.7	0.8	1.4	-0.9	1.1	-0.3	1.2
One hour access (shock baseline)	0.5	0.6	0.9	0.9	-0.8	0.9	-0.2
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.3	-0.2	0.4
Context. condit. distance diff. score	3.3	4.0	6.2	2.5	-2.4	1.6	-1.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.2	0.1	0.1	-0.4
Locomotion distance, session 1	0.5	0.6	1.2	-0.9	1.1	-0.5	0.4
Locomotion velocity, session 2	0.1	0.2	0.4	0.1	-0.0	0.6	-0.5
Locomotion distance, session 2	0.8	1.1	1.8	-1.2	1.4	-0.5	0.8
Locomotion velocity, session 3	0.3	0.4	0.7	0.8	-0.7	0.4	-0.4
Locomotion distance, session 3	0.6	0.7	1.0	-0.7	0.8	-0.8	1.0
Stereotopy head waving bouts, day 3	0.6	0.7	1.4	1.0	-1.2	0.6	0.0
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.0
Locomotion velocity, session 7	1.4	1.5	2.9	1.0	-0.7	1.3	-1.7
Locomotion distance, session 7	0.4	0.5	0.8	0.5	-0.5	0.9	-0.9
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	-0.7	0.8	-0.6	0.4
Stereotopy head waving duration, day 7	0.3	0.3	0.6	-0.7	0.7	-0.4	0.2
Locomotion velocity, session 8	1.0	1.2	1.3	1.1	-0.9	1.1	-1.2
Locomotion distance, session 8	1.3	2.0	2.8	1.7	-1.5	1.3	-1.1
Degree of sensitization distance	0.4	0.4	0.9	0.0	-0.1	0.8	-0.9
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.1	0.2	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.4	-0.3	0.2	-0.8
Condit. Reinf. active responses	0.1	0.1	0.1	-0.2	0.4	-0.3	-0.0
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.7	0.8	-0.5	0.6
Incentive salience index mean	0.1	0.2	0.4	-0.3	0.5	-0.6	0.1
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.3	0.5	-0.7	0.4
Time in familiar zone, hab. session 1	1.4	1.3	1.7	-1.2	1.0	-1.3	1.1
Time in novel zone, hab. session 1	1.3	1.2	1.5	1.2	-1.0	1.2	-1.0
Total zone transitions, hab. session 1	0.2	0.3	0.7	-0.8	0.8	-0.2	-0.0
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.3
Locomotion velocity, hab. session 1	0.2	0.2	0.4	-0.7	0.5	-0.4	-0.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.4	0.4	0.0	0.1
Total zone transitions, hab. session 2	0.2	0.3	0.8	0.3	-0.4	0.9	-0.4
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.3	0.2	0.2	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.0	-0.0	0.6	-0.4
Novelty place preference	0.1	0.1	0.2	-0.3	0.2	0.4	-0.2
Time in novel zone, NPP test	0.1	0.1	0.2	-0.1	0.0	0.5	-0.3
Total zone transitions, NPP test	0.1	0.2	0.3	0.4	-0.4	0.6	-0.4
Total locomotion distance, NPP test	0.3	0.4	0.7	0.7	-0.6	0.5	-0.9
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	-0.6	0.6	-0.7
Pavlov. Cond. lever latency	0.7	0.8	1.6	0.9	-1.3	0.9	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	0.9	-0.7	0.8	-0.6
Pavlov. Cond. change in total contacts	0.7	0.7	1.6	0.9	-0.5	0.6	-1.3
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	-0.2	0.2	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.4	0.4	-0.1	0.1	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.7	-0.5	0.9	-0.7	0.0
Pavlov. Cond. magazine entry number	0.6	0.7	1.1	-1.1	0.9	-0.8	0.6
Pavlov. Cond. intertrial magazine entries	1.3	1.5	2.1	-1.3	1.4	-1.1	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.5	-0.2	0.1	-0.5
Pavlov. Cond. response bias	0.2	0.3	0.5	0.7	-0.5	0.3	-0.5
Bone: apparent density	0.6	1.0	2.0	1.4	-1.3	-0.1	0.7
Bone surface	1.8	3.1	5.9	2.4	-2.4	0.9	-0.5
Bone volume	0.6	1.0	2.0	1.4	-1.4	-0.2	0.4
Bone: connectivity density	1.8	2.8	5.3	2.3	-2.2	1.0	-0.1
Bone: cortical apparent density	0.2	0.3	0.8	0.2	-0.2	0.5	-0.9
Bone: cortical area	3.0	4.5	6.0	2.4	-2.4	1.8	-1.8
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.5	0.4	-0.3	0.3
Bone: cortical thickness	2.6	4.3	5.7	2.4	-2.3	1.8	-1.7
Bone: cortical thickness	1.3	1.5	1.9	1.4	-1.3	1.3	-0.7
Bone: cortical tissue density	0.1	0.2	0.6	0.0	-0.0	0.3	-0.7
Bone: elastic displacement	0.1	0.1	0.3	0.6	-0.3	0.3	0.1
Bone: elastic work	1.2	1.6	2.8	1.7	-1.6	1.0	-0.3
Bone: endosteal estimation	0.1	0.2	0.7	0.1	-0.2	-0.0	0.9
Bone: endosteal perimeter	0.1	0.3	0.7	0.6	-0.8	0.3	0.2
Bone: final force	2.7	4.4	5.6	2.2	-2.4	2.2	-1.5
Bone: final moment	2.1	3.5	4.4	2.0	-2.1	1.9	-1.3
Bone: marrow area	0.1	0.2	0.9	-0.0	-0.1	-0.1	0.9
Bone: maximum diameter	0.7	1.3	2.2	1.4	-1.5	0.8	-0.5
Bone: maximum force	1.3	2.3	3.5	1.7	-1.9	1.4	-0.8
Bone: maximum moment	0.9	1.6	2.5	1.5	-1.6	1.2	-0.6
Bone: minimum diameter	0.0	0.0	0.0	-0.1	0.2	-0.1	0.2
Bone: periosteal estimation	0.8	1.6	2.7	1.5	-1.6	1.1	-0.5
Bone: periosteal perimeter	0.7	1.2	2.0	1.3	-1.4	0.8	-0.8
Bone: post-yield work	0.1	0.1	0.2	0.2	-0.2	-0.4	0.4
Bone: stiffness	0.9	1.4	1.8	1.1	-1.3	1.3	-0.9
Bone: tissue strength	1.4	1.4	1.8	-1.1	1.1	-1.2	1.3
Bone: trabecular number	1.2	1.8	3.4	1.8	-1.8	0.7	-0.1
Bone: trabecular spacing	1.8	2.3	3.4	-1.8	1.8	-1.4	0.8
Bone: trabecular thickness	1.8	2.2	4.2	2.1	-2.0	0.7	-0.3
Bone: trabecular tissue density	3.9	5.5	8.3	2.0	-2.1	2.3	-2.9
Breakpoint value in progressive ratio session	1.4	1.5	1.9	1.3	-1.2	1.0	-1.4
Distance traveled before self-admin	0.1	0.1	0.3	-0.1	0.0	0.3	-0.6
Distance traveled after self-admin	0.1	0.1	0.1	0.2	-0.0	0.4	-0.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.3	-0.4	0.7	-0.4
Delta time in open arm before/after self-admin	1.7	1.6	2.2	-1.3	1.5	-1.5	0.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.3	0.0	-0.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.1	0.2	0.1	0.4
Delta ambulatory time before/after self-admin	0.2	0.3	0.4	-0.4	0.7	-0.4	0.6
Time in closed arm before self-admin	0.2	0.3	0.4	0.5	-0.6	0.5	0.4
Time in closed arm after self-admin	0.2	0.2	0.4	0.2	-0.5	0.6	0.4
Time in open arm before self-admin	0.4	0.4	0.7	0.6	-0.4	0.8	-0.6
Time in open arm after self-admin	0.0	0.1	0.1	0.1	0.2	-0.3	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.3	-0.2	-0.2	-0.7
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.4	0.4	-0.6	1.0	-1.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.0	0.0	0.4	-0.5
Time to tail flick, test, before self-admin	0.5	0.5	0.9	0.9	-0.6	0.7	-0.3
Time to tail flick, test, after self-admin	0.5	0.5	0.8	0.7	-0.7	0.5	-0.9
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.0	-0.9	0.9	-0.9	1.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.5	0.3	-0.7	0.2
Ambulatory time before self-admin	0.3	0.3	0.6	0.3	-0.5	0.4	-0.8
Ambulatory time after self-admin	0.1	0.1	0.1	0.3	-0.1	0.2	-0.4
Total heroin consumption	0.5	0.5	0.9	-0.9	0.9	-0.7	-0.2
Area under the delay curve	1.4	1.5	3.2	0.9	-0.8	1.1	-1.8
Delay disc. indifference point, 0s delay	4.8	5.2	8.0	2.1	-2.1	2.0	-2.8
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.4	-0.3	0.6	-0.9
Delay disc. indifference point, 2s delay	1.0	1.2	3.3	0.7	-0.7	0.5	-1.8
Delay disc. indifference point, 24s delay	0.2	0.1	0.4	-0.1	0.2	0.4	-0.6
Delay disc. indifference point, 4s delay	0.5	0.6	1.6	0.5	-0.4	0.4	-1.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.4	-0.2	0.5	-0.7
Delay discount exponential model param	1.1	1.1	2.6	-0.8	0.6	-0.9	1.6
Delay discount hyperbolic model param	1.0	1.0	2.6	-0.7	0.6	-0.8	1.6
Fecal boli incidents, locomotor time 1	0.7	0.8	1.2	1.0	-1.1	1.0	-0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.5	0.5	-0.5	0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	-0.0	-0.1	-0.4	-0.8
Bouts of movement, locomotor time 1	0.5	0.5	0.9	0.8	-0.6	0.9	-0.3
Total resting periods, locomotor time 1	0.5	0.6	0.9	0.9	-0.7	0.9	-0.4
Rest time, locomotor task time 1	0.5	0.5	0.8	0.8	-0.9	0.6	-0.5
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.2	0.3	0.0	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.4	0.3	-0.1	0.6	-0.1
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.5	1.4	-1.6	0.8	-1.6
Bouts of movement, locomotor time 2	0.4	0.4	0.7	0.9	-0.7	0.5	-0.1
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.7	-0.6	0.4	-0.0
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	0.2	-0.6	0.2
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.0	0.0	0.5	0.0
Vertical activity count, locomotor time 2	0.6	0.6	1.5	0.8	-0.7	1.2	0.0
Weight adjusted by age	0.2	0.2	0.3	0.5	-0.3	-0.2	0.5
Seeking ratio, delayed vs. immediate footshock	3.1	3.6	4.7	-2.2	2.1	-1.6	1.6
Locomotion in novel chamber	0.1	0.2	0.4	-0.2	0.4	0.3	0.6
Locomotion in novel chamber post-restriction	1.0	1.2	2.0	1.2	-1.1	1.4	-0.3
Progressive ratio	1.0	1.2	1.7	-1.3	1.3	-0.9	0.8
Food seeking constrained by brief footshock	4.2	5.2	5.4	-2.3	2.2	-2.3	2.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.3	-0.4	-0.1	0.3
Run reversals in cocaine runway, females	0.6	0.6	0.7	-0.8	0.7	-0.9	0.6
Run reversals in cocaine runway, males	0.9	0.9	1.5	-0.8	1.0	-0.5	1.2
Latency to leave start box in cocaine runway	0.6	0.6	1.0	0.7	-0.7	0.8	-1.0
Latency to leave start box in cocaine runway, F	0.5	0.5	0.6	0.7	-0.7	0.8	-0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.3	-0.2	0.2
Cd content in liver	3.5	3.8	5.4	-2.1	2.3	-1.4	1.9
Co content in liver	0.9	1.1	2.2	-0.9	0.9	-0.7	1.5
Cu content in liver	1.2	1.5	2.2	-0.9	1.5	-1.2	1.3
Fe content in liver	0.8	1.0	2.0	1.4	-1.3	0.6	-0.3
K content in liver	0.0	0.0	0.1	0.4	0.1	-0.1	-0.2
Mg content in liver	0.3	0.3	0.7	0.8	-0.3	0.6	-0.4
Mn content in liver	0.5	0.5	0.9	-0.8	0.9	-0.6	0.6
Na content in liver	0.6	0.7	0.8	0.9	-0.9	0.7	-0.9
Rb content in liver	1.6	2.0	2.9	-1.3	1.7	-1.6	0.9
Se content in liver	2.2	2.6	4.1	2.0	-1.6	0.9	-1.7
Sr content in liver	0.5	0.5	1.2	-0.6	0.2	-0.6	1.1
Zn content in liver	0.4	0.4	0.7	0.8	-0.8	0.3	0.5