All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.
# | Tissue | Modality | RNA phenotype | h2 | h2 SE | h2 P | xQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | xQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000026204 | 0.24 | 0.1 | 9.7e-09 | 0.03 | 0.05 | 0.06 | 0.04 | 1.4e-04 | 3.0e-06 | 3.5e-07 | 9.7e-06 |
2 | Adipose | mRNA stability | ENSRNOG00000026204 | 0.5 | 0.11 | 0.0e+00 | 0.51 | 0.51 | 0.53 | 0.53 | 3.2e-65 | 3.0e-65 | 8.8e-70 | 3.7e-69 |
3 | BLA | gene expression | ENSRNOG00000026204 | 0.24 | 0.1 | 1.2e-10 | 0.19 | 0.19 | 0.17 | 0.2 | 2.5e-10 | 1.2e-10 | 1.9e-09 | 1.0e-10 |
4 | BLA | mRNA stability | ENSRNOG00000026204 | 0.15 | 0.1 | 6.4e-05 | 0.05 | 0.05 | 0.04 | 0.05 | 8.2e-04 | 1.1e-03 | 3.6e-03 | 8.1e-04 |
5 | Brain | gene expression | ENSRNOG00000026204 | 0.49 | 0.15 | 0.0e+00 | 0.35 | 0.35 | 0.37 | 0.37 | 6.1e-34 | 6.6e-34 | 1.5e-35 | 1.0e-35 |
6 | Brain | mRNA stability | ENSRNOG00000026204 | 0.59 | 0.12 | 0.0e+00 | 0.45 | 0.48 | 0.49 | 0.49 | 3.1e-46 | 1.3e-50 | 6.1e-51 | 7.7e-51 |
7 | Eye | gene expression | ENSRNOG00000026204 | 0.4 | 0.2 | 6.0e-03 | 0.01 | 0.07 | 0.08 | 0.03 | 2.2e-01 | 3.1e-02 | 2.3e-02 | 1.1e-01 |
8 | IL | gene expression | ENSRNOG00000026204 | 0.55 | 0.15 | 7.0e-10 | 0.35 | 0.35 | 0.35 | 0.34 | 2.5e-09 | 2.6e-09 | 3.8e-09 | 6.9e-09 |
9 | IL | mRNA stability | ENSRNOG00000026204 | 0.31 | 0.13 | 2.1e-06 | 0.26 | 0.26 | 0.24 | 0.29 | 5.7e-07 | 7.9e-07 | 1.8e-06 | 1.2e-07 |
10 | LHb | gene expression | ENSRNOG00000026204 | 0.56 | 0.2 | 7.5e-08 | 0.18 | 0.34 | 0.28 | 0.31 | 4.6e-05 | 4.9e-09 | 2.3e-07 | 4.9e-08 |
11 | LHb | mRNA stability | ENSRNOG00000026204 | 0.45 | 0.17 | 3.9e-06 | 0.22 | 0.2 | 0.22 | 0.26 | 5.4e-06 | 1.4e-05 | 5.1e-06 | 7.1e-07 |
12 | Liver | gene expression | ENSRNOG00000026204 | 0.23 | 0.1 | 0.0e+00 | 0.16 | 0.15 | 0.17 | 0.16 | 7.6e-18 | 3.5e-16 | 1.8e-18 | 9.9e-18 |
13 | Liver | intron excision ratio | chr1:255572081:255573295 | 0.58 | 0.13 | 0.0e+00 | 0.54 | 0.53 | 0.56 | 0.56 | 3.0e-70 | 1.1e-69 | 2.0e-75 | 6.8e-74 |
14 | Liver | intron excision ratio | chr1:255572081:255577291 | 0.09 | 0.05 | 4.2e-10 | 0.06 | 0.05 | 0.07 | 0.07 | 5.6e-07 | 1.8e-06 | 3.2e-08 | 4.4e-08 |
15 | Liver | intron excision ratio | chr1:255572081:255578402 | 0.25 | 0.1 | 0.0e+00 | 0.25 | 0.25 | 0.25 | 0.26 | 5.2e-28 | 2.6e-27 | 5.5e-28 | 2.0e-28 |
16 | Liver | mRNA stability | ENSRNOG00000026204 | 0.62 | 0.1 | 0.0e+00 | 0.57 | 0.58 | 0.58 | 0.59 | 1.0e-77 | 3.2e-79 | 4.2e-80 | 8.2e-81 |
17 | NAcc | gene expression | ENSRNOG00000026204 | 0.27 | 0.1 | 1.2e-15 | 0.21 | 0.21 | 0.2 | 0.2 | 2.4e-15 | 1.4e-15 | 5.8e-15 | 5.1e-15 |
18 | NAcc | mRNA stability | ENSRNOG00000026204 | 0.26 | 0.1 | 3.2e-15 | 0.17 | 0.17 | 0.16 | 0.17 | 8.4e-13 | 2.0e-12 | 7.8e-12 | 6.8e-13 |
19 | OFC | gene expression | ENSRNOG00000026204 | 0.51 | 0.14 | 9.9e-11 | 0.42 | 0.49 | 0.46 | 0.45 | 5.2e-11 | 2.3e-13 | 3.0e-12 | 4.4e-12 |
20 | OFC | mRNA stability | ENSRNOG00000026204 | 0.34 | 0.15 | 6.8e-07 | 0.22 | 0.21 | 0.29 | 0.24 | 6.4e-06 | 1.0e-05 | 1.1e-07 | 1.7e-06 |
21 | PL | gene expression | ENSRNOG00000026204 | 0.24 | 0.09 | 0.0e+00 | 0.21 | 0.25 | 0.25 | 0.24 | 6.1e-16 | 2.3e-19 | 4.6e-19 | 3.1e-18 |
22 | PL | intron excision ratio | chr1:255570406:255571940 | 0.03 | 0.02 | 8.9e-03 | 0.01 | 0.01 | 0.01 | 0.01 | 5.3e-02 | 2.3e-02 | 7.7e-02 | 7.2e-02 |
23 | PL | mRNA stability | ENSRNOG00000026204 | 0.33 | 0.12 | 0.0e+00 | 0.15 | 0.19 | 0.18 | 0.19 | 1.5e-11 | 4.1e-14 | 5.0e-14 | 3.6e-14 |
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BMI with tail | 5.3 | 17.2 | 36.2 | -0.9 | 4.8 | 1.9 | 5.0 | 3.7 | 4.5 | -3.3 | 2.2 | 6.0 | 3.9 | 4.9 | -5.1 | -4.3 | 2.0 | 4.8 | 4.7 | 2.3 | 5.0 | 3.1 | 5.8 | 2.7 | -4.7 | 4.5 |
BMI without tail | 2.0 | 4.3 | 9.3 | -0.3 | 2.2 | 1.1 | 2.3 | 2.1 | 2.0 | -2.1 | 1.4 | 3.1 | 2.2 | 2.2 | -2.5 | -1.8 | 0.8 | 2.2 | 2.3 | 1.5 | 2.5 | 2.0 | 2.9 | 1.8 | -2.2 | 1.9 |
Body weight | 5.6 | 23.7 | 52.8 | -0.8 | 5.6 | 2.4 | 5.8 | 4.2 | 5.2 | -3.9 | 2.5 | 7.3 | 4.5 | 5.7 | -6.0 | -5.0 | 2.3 | 5.8 | 5.5 | 2.6 | 5.7 | 3.6 | 7.2 | 3.1 | -5.5 | 5.2 |
Epididymis fat weight | 8.8 | 20.5 | 45.8 | -0.6 | 5.1 | 2.9 | 5.3 | 4.3 | 4.9 | -1.9 | 2.8 | 6.6 | 4.6 | 5.1 | -5.4 | -4.8 | 1.5 | 5.4 | 5.0 | 2.8 | 5.5 | 3.8 | 6.8 | 3.5 | -4.7 | 4.7 |
Glucose | 3.7 | 5.7 | 11.0 | -0.9 | 3.0 | 1.1 | 2.7 | 2.0 | 3.1 | -0.9 | 1.2 | 3.3 | 2.3 | 2.7 | -3.2 | -3.1 | 1.6 | 3.0 | 2.9 | 1.1 | 2.8 | 1.4 | 3.0 | 1.2 | -2.5 | 2.6 |
Heart weight | 2.2 | 3.1 | 5.7 | -1.1 | 2.2 | 0.6 | 2.1 | 1.3 | 2.2 | -0.7 | 0.4 | 2.4 | 1.4 | 2.2 | -2.3 | -2.1 | 1.1 | 2.2 | 2.2 | 0.6 | 1.9 | 0.9 | 2.4 | 0.8 | -2.1 | 2.2 |
Left kidney weight | 2.6 | 7.4 | 18.0 | -2.3 | 3.5 | -2.3 | 2.2 | -1.4 | 2.4 | -4.2 | -2.7 | 3.1 | -1.1 | 2.6 | -2.3 | -2.0 | 3.8 | 2.2 | 3.0 | -2.7 | 1.8 | -1.8 | 3.3 | -2.1 | -4.0 | 3.0 |
Right kidney weight | 4.1 | 11.6 | 25.5 | -3.0 | 4.5 | -1.5 | 3.7 | 0.1 | 3.9 | -4.4 | -1.5 | 4.4 | 0.5 | 4.0 | -3.8 | -3.5 | 3.9 | 3.6 | 4.1 | -1.3 | 3.5 | -0.7 | 4.5 | -0.9 | -5.1 | 4.1 |
Tail length | 0.1 | 0.3 | 0.8 | 0.4 | 0.5 | 0.7 | 0.2 | 0.8 | 0.2 | 0.4 | 0.6 | 0.8 | 0.7 | 0.1 | -0.6 | -0.5 | -0.1 | 0.5 | 0.4 | 0.6 | 0.3 | 0.9 | 0.8 | 0.9 | -0.2 | 0.1 |
Length with tail | 1.3 | 4.9 | 12.1 | -0.5 | 2.8 | 0.9 | 2.6 | 1.6 | 2.5 | -1.7 | 0.7 | 3.4 | 1.8 | 2.6 | -2.8 | -2.4 | 1.2 | 2.8 | 2.6 | 0.8 | 2.5 | 1.3 | 3.5 | 1.2 | -2.7 | 2.5 |
Length without tail | 3.8 | 8.3 | 17.0 | -1.0 | 3.6 | 1.0 | 3.7 | 1.9 | 3.5 | -1.8 | 0.8 | 4.1 | 2.2 | 3.6 | -3.5 | -3.3 | 1.7 | 3.7 | 3.4 | 0.9 | 3.3 | 1.4 | 4.1 | 1.2 | -3.4 | 3.5 |
Liver weight, left | 2.7 | 4.3 | 10.0 | -0.2 | 2.1 | 1.7 | 2.4 | 2.3 | 2.1 | -0.4 | 1.8 | 2.9 | 2.3 | 2.3 | -2.3 | -1.8 | 0.2 | 2.5 | 2.2 | 1.6 | 2.3 | 2.1 | 3.2 | 2.0 | -1.9 | 2.0 |
Liver weight, right | 4.5 | 7.4 | 18.0 | -0.5 | 3.3 | 1.3 | 3.3 | 2.2 | 3.0 | -1.6 | 1.5 | 4.0 | 2.4 | 3.1 | -3.3 | -2.8 | 1.4 | 3.3 | 3.2 | 1.3 | 3.2 | 2.0 | 4.2 | 1.7 | -3.1 | 2.9 |
Parametrial fat weight | 5.9 | 11.6 | 20.4 | 0.2 | 3.1 | 3.4 | 3.7 | 4.3 | 3.2 | 0.2 | 3.2 | 4.4 | 4.3 | 3.4 | -3.9 | -3.3 | -0.2 | 3.7 | 3.2 | 3.5 | 3.9 | 3.9 | 4.5 | 3.8 | -2.6 | 2.9 |
Retroperitoneal fat weight | 7.7 | 25.6 | 53.4 | -0.8 | 5.8 | 3.0 | 6.0 | 4.7 | 5.5 | -2.7 | 2.9 | 7.3 | 5.0 | 5.8 | -6.3 | -5.5 | 2.0 | 6.1 | 5.7 | 3.1 | 6.1 | 4.0 | 7.3 | 3.6 | -5.5 | 5.3 |
Intraocular pressure | 3.9 | 5.5 | 8.7 | -1.0 | 2.3 | 2.0 | 2.9 | 2.7 | 2.5 | 1.0 | 1.9 | 2.5 | 2.8 | 2.7 | -2.5 | -2.6 | 0.1 | 2.9 | 2.5 | 2.2 | 2.9 | 2.3 | 2.7 | 2.3 | -1.9 | 2.6 |
Extensor digitorum longus weight | 0.3 | 1.3 | 3.0 | 0.9 | 0.4 | 1.6 | 1.0 | 1.6 | 0.5 | -0.2 | 1.7 | 1.4 | 1.7 | 0.7 | -0.9 | -0.5 | -0.7 | 0.7 | 0.5 | 1.6 | 1.1 | 1.7 | 1.3 | 1.7 | -0.3 | 0.4 |
Soleus weight | 2.3 | 6.8 | 14.7 | -1.5 | 3.6 | 0.0 | 2.9 | 1.1 | 3.1 | -2.0 | 0.1 | 3.8 | 1.4 | 3.0 | -3.3 | -3.2 | 2.4 | 2.9 | 3.3 | 0.0 | 3.1 | 0.5 | 3.8 | 0.3 | -3.6 | 2.9 |
Tibialis anterior weight | 0.1 | 0.5 | 2.1 | 0.2 | -0.3 | 1.1 | 0.1 | 1.0 | 0.0 | 0.5 | 1.2 | 0.1 | 1.1 | 0.0 | 0.0 | 0.1 | -0.9 | -0.1 | -0.1 | 1.4 | 0.5 | 1.1 | 0.1 | 1.2 | 0.3 | -0.4 |
Tibia length | 1.2 | 3.5 | 7.2 | -1.4 | 2.5 | -0.2 | 2.0 | 0.6 | 2.2 | -2.2 | -0.4 | 2.4 | 0.6 | 2.2 | -2.4 | -2.1 | 1.9 | 2.0 | 2.4 | -0.3 | 2.0 | 0.1 | 2.5 | -0.1 | -2.7 | 2.2 |
Number of licking bursts | 0.5 | 0.6 | 1.7 | 0.8 | 0.2 | 1.2 | 0.3 | 1.1 | 0.1 | 0.8 | 1.2 | 0.7 | 1.0 | 0.2 | -0.3 | -0.1 | -0.8 | 0.5 | 0.2 | 1.0 | 0.2 | 1.3 | 0.8 | 1.3 | 0.2 | 0.1 |
Food consumed during 24 hour testing period | 0.1 | 0.1 | 0.4 | 0.3 | -0.3 | -0.4 | -0.2 | -0.3 | -0.3 | -0.6 | -0.2 | -0.2 | -0.4 | -0.2 | 0.1 | 0.3 | 0.2 | -0.3 | -0.2 | -0.5 | -0.4 | -0.2 | -0.5 | -0.4 | 0.4 | -0.2 |
Times rat made contact with spout | 0.3 | 0.3 | 0.8 | -0.3 | 0.9 | -0.5 | 0.5 | -0.2 | 0.5 | -0.4 | -0.5 | 0.8 | -0.3 | 0.6 | -0.4 | -0.4 | 0.8 | 0.5 | 0.8 | -0.6 | 0.6 | -0.2 | 0.9 | -0.3 | -0.9 | 0.7 |
Mean time between licks in bursts | 0.2 | 0.2 | 0.7 | 0.6 | -0.3 | 0.7 | -0.0 | 0.6 | -0.3 | 0.8 | 0.8 | 0.0 | 0.5 | -0.2 | 0.1 | 0.2 | -0.8 | -0.1 | -0.3 | 0.7 | -0.2 | 0.8 | 0.1 | 0.8 | 0.5 | -0.3 |
Mean num. licks in bursts | 1.0 | 1.1 | 2.8 | -1.3 | 0.9 | -1.6 | 0.4 | -1.2 | 0.7 | -1.3 | -1.6 | 0.2 | -1.1 | 0.6 | -0.4 | -0.6 | 1.7 | 0.3 | 0.8 | -1.5 | 0.6 | -1.5 | 0.2 | -1.5 | -1.2 | 0.8 |
Std. dev. time between licks in bursts | 0.4 | 0.5 | 2.4 | 0.6 | -0.7 | 0.3 | -0.7 | -0.2 | -1.0 | 1.6 | 0.3 | -0.8 | -0.2 | -0.7 | 1.0 | 0.9 | -1.0 | -0.8 | -0.8 | 0.3 | -0.7 | 0.3 | -0.4 | 0.4 | 0.7 | -0.8 |
Water consumed over 24 hours | 0.5 | 0.5 | 1.6 | -0.4 | 0.8 | -1.0 | 0.5 | -0.6 | 0.6 | -1.2 | -0.8 | 0.7 | -0.5 | 0.5 | -0.5 | -0.5 | 1.2 | 0.5 | 0.7 | -1.0 | 0.3 | -0.7 | 0.5 | -0.8 | -0.9 | 0.7 |
Indifference point 0 sec | 2.8 | 4.6 | 7.8 | -0.3 | 2.3 | 1.7 | 2.4 | 2.4 | 2.1 | 0.3 | 1.7 | 2.8 | 2.5 | 2.3 | -2.6 | -2.6 | 0.3 | 2.6 | 2.2 | 1.9 | 2.7 | 2.0 | 2.6 | 2.0 | -1.9 | 2.1 |
Indifference point AUC | 0.6 | 0.7 | 2.6 | -0.1 | 0.3 | 1.1 | 0.2 | 1.1 | 0.2 | 1.6 | 1.1 | 0.3 | 1.1 | 0.2 | -0.1 | -0.4 | -0.8 | 0.5 | 0.4 | 1.4 | 0.6 | 1.2 | 0.6 | 1.4 | -0.1 | 0.1 |
Indifference point function ln k | 0.1 | 0.2 | 1.3 | -0.2 | 0.1 | -0.4 | 0.3 | -0.2 | 0.3 | -1.1 | -0.4 | 0.1 | -0.3 | 0.2 | -0.6 | -0.4 | 0.6 | 0.0 | 0.2 | -0.5 | 0.3 | -0.5 | -0.2 | -0.7 | -0.3 | 0.2 |
Indifference point function log k | 0.1 | 0.2 | 1.3 | -0.2 | 0.1 | -0.4 | 0.3 | -0.2 | 0.3 | -1.1 | -0.4 | 0.1 | -0.3 | 0.2 | -0.6 | -0.4 | 0.6 | 0.0 | 0.2 | -0.5 | 0.3 | -0.5 | -0.2 | -0.7 | -0.3 | 0.2 |
Delay discounting total patch changes 0 sec | 2.8 | 4.6 | 7.5 | -0.1 | 2.1 | 1.9 | 2.4 | 2.6 | 2.1 | 0.5 | 1.9 | 2.7 | 2.6 | 2.2 | -2.5 | -2.5 | 0.1 | 2.6 | 2.1 | 2.1 | 2.6 | 2.2 | 2.5 | 2.2 | -1.7 | 2.0 |
Delay discounting total patch changes 12 sec | 1.1 | 1.4 | 3.7 | 0.8 | 0.6 | 1.7 | 0.7 | 1.8 | 0.3 | 1.3 | 1.8 | 1.1 | 1.7 | 0.6 | -0.7 | -0.6 | -1.0 | 1.0 | 0.5 | 1.8 | 0.8 | 1.9 | 1.2 | 1.9 | -0.2 | 0.4 |
Delay discounting total patch changes 18 sec | 2.7 | 3.6 | 6.9 | -0.0 | 1.6 | 2.3 | 1.7 | 2.6 | 1.3 | 1.8 | 2.1 | 1.8 | 2.6 | 1.5 | -1.5 | -1.7 | -0.7 | 2.0 | 1.6 | 2.5 | 2.2 | 2.5 | 2.0 | 2.6 | -1.0 | 1.3 |
Delay discounting total patch changes 24 sec | 2.1 | 2.6 | 6.5 | 0.5 | 0.9 | 2.3 | 1.2 | 2.4 | 0.8 | 1.8 | 2.1 | 1.4 | 2.3 | 0.9 | -1.0 | -1.1 | -1.1 | 1.4 | 1.0 | 2.4 | 1.6 | 2.4 | 1.7 | 2.6 | -0.5 | 0.7 |
Delay discounting total patch changes 6 sec | 3.9 | 6.0 | 9.3 | -0.5 | 2.5 | 2.2 | 2.7 | 3.0 | 2.4 | 0.6 | 2.0 | 3.0 | 3.0 | 2.6 | -2.7 | -2.7 | 0.1 | 2.9 | 2.5 | 2.4 | 2.8 | 2.6 | 3.0 | 2.6 | -1.9 | 2.3 |
Delay discounting time to switch 0 sec | 0.4 | 0.6 | 1.4 | 0.3 | -0.8 | -0.6 | -0.8 | -1.0 | -0.8 | -0.4 | -0.7 | -0.7 | -1.0 | -0.8 | 1.0 | 1.0 | -0.0 | -0.8 | -0.8 | -1.0 | -1.2 | -0.8 | -0.6 | -0.8 | 0.7 | -0.6 |
Delay discounting water rate 0 sec | 0.6 | 0.9 | 1.7 | -0.4 | 1.0 | 0.5 | 1.1 | 1.1 | 1.1 | -0.0 | 0.8 | 1.0 | 1.1 | 1.1 | -1.3 | -1.3 | 0.3 | 1.1 | 1.0 | 0.8 | 1.2 | 0.8 | 0.9 | 0.7 | -0.9 | 0.9 |
Delay discounting water rate 12 sec | 1.4 | 2.1 | 5.1 | 0.7 | 0.7 | 1.8 | 1.2 | 2.3 | 0.9 | 0.7 | 2.2 | 1.2 | 2.2 | 1.0 | -1.4 | -1.4 | -0.6 | 1.2 | 0.8 | 2.3 | 1.4 | 2.0 | 1.1 | 2.0 | -0.4 | 0.6 |
Delay discounting water rate 18 sec | 0.5 | 0.7 | 1.6 | -0.9 | 1.1 | -0.3 | 0.9 | 0.4 | 0.9 | -1.2 | -0.2 | 1.0 | 0.3 | 1.0 | -1.2 | -1.0 | 1.0 | 0.8 | 1.1 | -0.1 | 1.0 | -0.1 | 1.0 | -0.1 | -1.3 | 0.9 |
Delay discounting water rate 24 sec | 0.7 | 1.0 | 2.2 | -0.5 | 1.4 | -0.3 | 1.2 | 0.2 | 0.9 | -1.0 | -0.2 | 1.4 | 0.2 | 1.3 | -1.1 | -1.0 | 1.0 | 1.1 | 1.2 | -0.2 | 1.1 | 0.1 | 1.5 | 0.0 | -1.5 | 1.2 |
Delay discounting water rate 6 sec | 0.3 | 0.5 | 1.2 | -0.5 | 1.0 | -0.5 | 0.7 | -0.0 | 0.8 | -0.7 | -0.3 | 0.6 | -0.0 | 0.8 | -0.9 | -1.1 | 1.1 | 0.6 | 0.9 | -0.3 | 0.8 | -0.2 | 0.5 | -0.4 | -1.0 | 0.8 |
Locomotor activity | 1.3 | 2.0 | 4.3 | -1.1 | 1.7 | -0.2 | 1.7 | 0.6 | 1.8 | -1.6 | -0.0 | 2.1 | 0.8 | 1.7 | -1.9 | -1.7 | 1.3 | 1.8 | 1.7 | -0.1 | 1.5 | 0.1 | 1.8 | -0.0 | -1.8 | 1.8 |
Locomotor testing distance | 2.2 | 3.6 | 6.7 | -2.0 | 2.4 | -1.0 | 2.2 | 0.1 | 2.4 | -1.8 | -0.8 | 2.2 | 0.3 | 2.3 | -2.3 | -2.4 | 2.3 | 2.3 | 2.3 | -0.8 | 1.8 | -0.6 | 1.8 | -0.7 | -2.4 | 2.6 |
Locomotor testing rearing | 0.9 | 1.5 | 3.1 | -0.8 | 1.5 | -0.6 | 1.5 | 0.1 | 1.4 | -1.3 | -0.3 | 1.7 | 0.3 | 1.5 | -1.5 | -1.4 | 1.4 | 1.6 | 1.4 | -0.6 | 0.9 | -0.3 | 1.4 | -0.4 | -1.4 | 1.7 |
Light reinforcement 1 | 1.4 | 2.5 | 4.5 | 1.1 | -1.8 | -0.7 | -2.0 | -1.4 | -2.0 | 0.4 | -0.9 | -2.0 | -1.6 | -2.0 | 2.0 | 2.1 | -0.8 | -2.0 | -1.9 | -1.0 | -1.7 | -0.9 | -1.7 | -0.9 | 1.6 | -1.9 |
Light reinforcement 2 | 2.4 | 3.1 | 5.8 | 0.9 | -1.8 | -1.4 | -2.1 | -2.0 | -2.2 | 0.2 | -1.2 | -2.1 | -2.0 | -2.1 | 2.3 | 2.4 | -0.5 | -2.1 | -2.0 | -1.4 | -2.0 | -1.5 | -1.8 | -1.4 | 1.4 | -1.9 |
Reaction time number correct | 0.6 | 0.8 | 1.8 | 0.4 | 0.8 | 0.9 | 0.9 | 1.3 | 0.7 | 0.2 | 1.2 | 1.1 | 1.2 | 0.9 | -0.9 | -0.9 | -0.2 | 0.9 | 0.7 | 1.1 | 0.7 | 1.1 | 1.2 | 1.1 | -0.6 | 0.6 |
Reaction time mean minus median | 0.8 | 1.1 | 3.6 | -1.9 | 1.2 | 0.0 | 1.3 | 0.3 | 1.4 | -0.9 | -0.4 | 1.1 | 0.5 | 1.4 | -1.0 | -1.0 | 1.0 | 1.2 | 1.4 | -0.2 | 1.1 | -0.1 | 1.1 | -0.0 | -1.2 | 1.4 |
Reaction time mean minus median AUC | 1.0 | 1.3 | 3.3 | -1.8 | 1.3 | -0.8 | 1.1 | -0.4 | 1.2 | -1.5 | -1.1 | 1.1 | -0.2 | 1.3 | -0.9 | -0.9 | 1.5 | 1.0 | 1.4 | -1.0 | 0.8 | -0.7 | 1.1 | -0.7 | -1.5 | 1.4 |
Reaction time num false alarms | 0.1 | 0.1 | 0.3 | 0.1 | -0.3 | -0.3 | -0.3 | -0.2 | -0.5 | -0.2 | -0.2 | -0.2 | -0.3 | -0.3 | 0.4 | 0.6 | -0.2 | -0.4 | -0.4 | -0.1 | -0.1 | -0.1 | -0.1 | -0.0 | 0.0 | -0.3 |
Reaction time num false alarms AUC | 0.1 | 0.1 | 0.4 | -0.3 | 0.0 | -0.6 | -0.2 | -0.4 | -0.2 | -0.3 | -0.5 | -0.0 | -0.4 | -0.1 | 0.2 | 0.2 | 0.3 | -0.1 | -0.1 | -0.4 | 0.1 | -0.4 | 0.0 | -0.3 | -0.3 | -0.0 |
Reaction time trials correct on left | 0.6 | 0.8 | 1.8 | 0.4 | 0.8 | 0.9 | 0.9 | 1.3 | 0.7 | 0.2 | 1.2 | 1.1 | 1.2 | 0.9 | -0.9 | -0.9 | -0.2 | 0.9 | 0.7 | 1.1 | 0.7 | 1.1 | 1.2 | 1.1 | -0.6 | 0.6 |
Reaction time trials on left | 0.6 | 0.9 | 1.9 | 0.4 | 0.8 | 0.9 | 1.0 | 1.4 | 0.8 | 0.2 | 1.2 | 1.2 | 1.2 | 0.9 | -0.9 | -0.9 | -0.1 | 0.9 | 0.8 | 1.1 | 0.8 | 1.2 | 1.2 | 1.1 | -0.6 | 0.7 |
Reaction time mean | 0.7 | 1.0 | 2.8 | -1.7 | 1.2 | -0.3 | 1.2 | 0.2 | 1.5 | -0.3 | -0.4 | 0.9 | 0.4 | 1.2 | -1.2 | -1.3 | 1.2 | 1.2 | 1.3 | -0.3 | 1.0 | -0.3 | 0.7 | -0.3 | -1.0 | 1.3 |
Reaction time mean AUC | 0.3 | 0.4 | 1.8 | -1.3 | 0.7 | -0.2 | 0.8 | 0.0 | 1.0 | -0.1 | -0.4 | 0.5 | 0.2 | 0.8 | -0.7 | -0.9 | 0.8 | 0.8 | 0.9 | -0.3 | 0.6 | -0.4 | 0.4 | -0.3 | -0.6 | 0.9 |
Median of all reaction times | 0.6 | 0.8 | 2.1 | -1.4 | 1.1 | -0.5 | 1.0 | -0.0 | 1.3 | -0.4 | -0.5 | 0.7 | 0.2 | 1.0 | -1.1 | -1.3 | 1.2 | 1.1 | 1.2 | -0.4 | 0.9 | -0.5 | 0.5 | -0.5 | -1.0 | 1.2 |
Reaction time omissions | 0.2 | 0.2 | 0.7 | 0.1 | 0.4 | 0.5 | 0.6 | 0.5 | 0.3 | -0.7 | 0.3 | 0.7 | 0.6 | 0.5 | -0.3 | -0.1 | -0.1 | 0.5 | 0.4 | 0.5 | 0.7 | 0.5 | 0.8 | 0.5 | -0.5 | 0.4 |
Reaction time false alarm rate | 0.2 | 0.3 | 0.7 | -0.2 | -0.5 | -0.7 | -0.7 | -0.8 | -0.6 | -0.1 | -0.7 | -0.6 | -0.8 | -0.6 | 0.7 | 0.7 | -0.0 | -0.6 | -0.6 | -0.6 | -0.4 | -0.6 | -0.6 | -0.6 | 0.2 | -0.5 |
Reaction time premature initiation rate | 0.9 | 1.2 | 2.8 | -1.4 | 1.4 | -1.1 | 0.6 | -0.7 | 1.1 | -0.9 | -1.4 | 0.7 | -0.6 | 0.8 | -0.9 | -1.2 | 1.7 | 0.8 | 1.2 | -1.2 | 0.9 | -1.1 | 0.9 | -1.1 | -1.4 | 1.1 |
Reaction time premature initiations | 1.3 | 1.8 | 4.0 | -1.4 | 2.0 | -0.7 | 1.3 | -0.0 | 1.6 | -1.0 | -0.9 | 1.5 | 0.0 | 1.4 | -1.5 | -1.8 | 1.8 | 1.5 | 1.8 | -0.7 | 1.4 | -0.5 | 1.6 | -0.5 | -1.9 | 1.6 |
Std. dev. reaction times | 2.1 | 2.9 | 5.3 | -2.2 | 2.1 | 0.1 | 2.2 | 0.8 | 2.3 | -0.6 | -0.1 | 2.0 | 1.1 | 2.2 | -2.0 | -2.0 | 1.4 | 2.2 | 2.2 | 0.1 | 2.0 | 0.3 | 2.0 | 0.3 | -1.9 | 2.3 |
Reaction time trials completed | 0.6 | 0.9 | 1.9 | 0.4 | 0.8 | 0.9 | 1.0 | 1.4 | 0.8 | 0.2 | 1.2 | 1.2 | 1.2 | 0.9 | -0.9 | -0.9 | -0.1 | 0.9 | 0.8 | 1.1 | 0.8 | 1.2 | 1.2 | 1.1 | -0.6 | 0.7 |
Reaction time trials AUC | 0.7 | 1.0 | 2.0 | 0.3 | 0.9 | 1.0 | 1.0 | 1.4 | 0.8 | 0.3 | 1.2 | 1.2 | 1.3 | 1.0 | -1.0 | -1.0 | -0.1 | 1.0 | 0.8 | 1.1 | 0.8 | 1.2 | 1.3 | 1.2 | -0.7 | 0.7 |
Social response proportion | 2.6 | 2.8 | 9.2 | -1.6 | 2.0 | -1.2 | 1.5 | -0.4 | 1.7 | -3.0 | -1.5 | 1.9 | -0.4 | 1.8 | -1.5 | -1.4 | 2.2 | 1.4 | 1.8 | -1.3 | 1.4 | -0.9 | 1.8 | -1.1 | -2.4 | 1.9 |
Social responses | 3.9 | 5.1 | 10.0 | -1.5 | 2.7 | 1.1 | 2.8 | 1.9 | 2.7 | -1.0 | 0.6 | 3.2 | 1.9 | 2.8 | -2.7 | -2.5 | 1.0 | 2.8 | 2.6 | 1.0 | 2.8 | 1.3 | 3.1 | 1.3 | -2.5 | 2.7 |
Social time | 1.5 | 2.0 | 4.0 | -1.3 | 1.8 | -0.4 | 1.5 | 0.3 | 1.6 | -1.8 | -0.6 | 2.0 | 0.3 | 1.6 | -1.5 | -1.3 | 1.4 | 1.6 | 1.7 | -0.5 | 1.4 | -0.3 | 2.0 | -0.3 | -2.0 | 1.7 |
Conditioned locomotion | 0.1 | 0.1 | 0.3 | -0.4 | -0.1 | -0.4 | -0.2 | -0.4 | -0.0 | -0.1 | -0.6 | -0.3 | -0.5 | -0.2 | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | -0.5 | -0.1 | -0.5 | -0.3 | -0.5 | 0.1 | -0.2 |
Cocaine response after cond. corrected | 2.1 | 2.3 | 5.8 | -1.1 | -0.6 | -2.2 | -1.1 | -2.4 | -0.8 | -0.4 | -2.3 | -1.6 | -2.3 | -0.8 | 1.3 | 1.0 | 1.0 | -1.2 | -0.7 | -2.1 | -1.4 | -2.3 | -1.5 | -2.2 | 0.3 | -0.5 |
Cocaine response after cond. not corrected | 1.9 | 2.1 | 4.4 | -0.6 | -1.1 | -1.8 | -1.3 | -2.1 | -1.1 | -0.1 | -1.8 | -1.8 | -2.0 | -1.2 | 1.6 | 1.2 | 0.4 | -1.4 | -1.1 | -1.8 | -1.7 | -2.0 | -1.7 | -1.9 | 0.8 | -0.8 |
Cocaine response before conditioning | 0.8 | 0.9 | 2.8 | 1.5 | -0.9 | 1.4 | -0.4 | 1.1 | -0.6 | 1.0 | 1.7 | -0.2 | 0.9 | -0.7 | 0.3 | 0.5 | -1.5 | -0.3 | -0.8 | 1.2 | -0.4 | 1.1 | -0.3 | 1.1 | 1.2 | -0.8 |
Saline control response | 0.3 | 0.4 | 1.6 | -1.3 | 0.4 | -0.8 | 0.4 | -0.6 | 0.6 | -0.7 | -0.8 | 0.1 | -0.3 | 0.5 | -0.1 | -0.4 | 0.9 | 0.3 | 0.5 | -0.6 | 0.2 | -0.8 | 0.0 | -0.7 | -0.6 | 0.6 |
Condit. Reinf. active minus inactive responses | 2.7 | 3.3 | 7.6 | -0.7 | 0.9 | 2.4 | 1.8 | 2.6 | 1.4 | 2.0 | 2.2 | 1.1 | 2.8 | 1.6 | -1.4 | -1.6 | -1.0 | 1.7 | 1.4 | 2.7 | 1.7 | 2.4 | 1.1 | 2.6 | -0.4 | 1.3 |
Condit. Reinf. active-inactive response ratio | 0.8 | 0.9 | 3.0 | -0.1 | 0.0 | 1.4 | 0.6 | 1.5 | 0.3 | 1.3 | 1.3 | 0.0 | 1.4 | 0.5 | -0.3 | -0.5 | -1.0 | 0.4 | 0.3 | 1.7 | 0.7 | 1.4 | 0.1 | 1.6 | 0.1 | 0.2 |
Condit. Reinf. active responses | 4.2 | 5.9 | 12.1 | -0.9 | 1.6 | 3.0 | 2.6 | 3.3 | 2.2 | 2.1 | 2.7 | 2.1 | 3.5 | 2.3 | -2.2 | -2.4 | -0.9 | 2.7 | 2.1 | 3.1 | 2.4 | 3.0 | 2.1 | 3.1 | -0.9 | 2.0 |
Condit. Reinf. inactive responses | 2.2 | 2.7 | 4.7 | -0.5 | 1.3 | 1.9 | 1.8 | 2.0 | 1.7 | 1.2 | 1.7 | 1.9 | 2.2 | 1.7 | -1.7 | -1.7 | -0.3 | 2.1 | 1.5 | 1.7 | 1.6 | 1.7 | 1.9 | 1.8 | -0.7 | 1.6 |
Condit. Reinf. lever presses | 0.8 | 1.0 | 2.7 | 0.1 | 0.5 | 1.5 | 0.7 | 1.5 | 0.4 | 1.6 | 1.3 | 0.8 | 1.4 | 0.6 | -0.6 | -0.6 | -0.8 | 0.8 | 0.6 | 1.4 | 0.7 | 1.6 | 1.0 | 1.6 | -0.1 | 0.4 |
Condit. Reinf. lever reinforcers received | 3.1 | 4.3 | 8.8 | -0.8 | 1.4 | 2.6 | 2.2 | 2.8 | 1.8 | 2.1 | 2.3 | 1.7 | 3.0 | 2.0 | -1.8 | -2.0 | -0.8 | 2.3 | 1.8 | 2.7 | 2.1 | 2.6 | 1.8 | 2.7 | -0.7 | 1.7 |
Pavlov. Cond. lever latency | 0.7 | 1.0 | 4.5 | -0.2 | -0.2 | -1.5 | -0.5 | -1.4 | -0.1 | -2.1 | -1.3 | -0.5 | -1.3 | -0.3 | 0.2 | 0.3 | 1.2 | -0.6 | -0.2 | -1.5 | -0.5 | -1.5 | -0.8 | -1.7 | -0.2 | -0.2 |
Pavlov. Cond. magazine entry latency | 0.6 | 0.7 | 1.8 | 0.6 | 0.7 | 0.9 | 0.7 | 1.0 | 0.4 | 0.6 | 0.9 | 1.2 | 0.9 | 0.5 | -0.7 | -0.5 | -0.3 | 0.8 | 0.6 | 0.7 | 0.8 | 1.1 | 1.3 | 1.1 | -0.4 | 0.5 |
Pavlov. Cond. change in total contacts | 1.1 | 1.6 | 3.3 | -0.2 | 0.8 | 1.6 | 1.2 | 1.7 | 0.8 | 1.7 | 1.4 | 1.2 | 1.7 | 1.1 | -0.9 | -1.0 | -0.7 | 1.3 | 1.0 | 1.6 | 1.1 | 1.7 | 1.4 | 1.8 | -0.4 | 0.9 |
Pavlov. Cond. index score | 1.1 | 1.4 | 2.8 | -0.1 | 1.0 | 1.2 | 1.2 | 1.5 | 0.8 | 1.2 | 1.1 | 1.5 | 1.4 | 1.1 | -1.0 | -1.0 | -0.4 | 1.3 | 1.0 | 1.2 | 1.2 | 1.5 | 1.7 | 1.5 | -0.7 | 1.0 |
Pavlov. Cond. latency score | 1.0 | 1.2 | 2.6 | 0.1 | 0.9 | 1.3 | 1.0 | 1.4 | 0.7 | 1.2 | 1.1 | 1.4 | 1.4 | 0.9 | -0.9 | -0.8 | -0.5 | 1.1 | 0.9 | 1.2 | 1.1 | 1.5 | 1.6 | 1.5 | -0.5 | 0.8 |
Pavlov. Cond. lever contacts | 0.4 | 0.6 | 1.9 | -0.0 | 0.6 | 0.9 | 0.6 | 1.0 | 0.4 | 1.4 | 0.8 | 0.8 | 0.9 | 0.5 | -0.5 | -0.6 | -0.4 | 0.8 | 0.6 | 0.9 | 0.6 | 1.1 | 1.1 | 1.1 | -0.3 | 0.5 |
Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.8 | -0.4 | -0.7 | -0.9 | -0.7 | -1.0 | -0.4 | -0.5 | -0.8 | -1.2 | -0.9 | -0.6 | 0.7 | 0.5 | 0.2 | -0.8 | -0.7 | -0.6 | -0.8 | -1.1 | -1.4 | -1.0 | 0.4 | -0.6 |
Pavlov. Cond. intertrial magazine entries | 0.1 | 0.1 | 0.2 | 0.4 | 0.0 | 0.4 | 0.2 | 0.4 | 0.2 | -0.1 | 0.4 | 0.3 | 0.4 | 0.1 | -0.3 | -0.1 | -0.2 | 0.2 | 0.1 | 0.3 | 0.0 | 0.4 | 0.2 | 0.3 | 0.1 | 0.1 |
Pavlov. Cond. lever-magazine prob. diff. | 1.0 | 1.3 | 2.8 | -0.3 | 1.2 | 1.0 | 1.2 | 1.3 | 0.9 | 1.1 | 0.9 | 1.5 | 1.3 | 1.1 | -1.0 | -1.1 | -0.2 | 1.3 | 1.1 | 1.0 | 1.2 | 1.3 | 1.7 | 1.4 | -0.8 | 1.1 |
Pavlov. Cond. response bias | 0.8 | 1.1 | 2.1 | 0.1 | 0.9 | 1.2 | 0.9 | 1.4 | 0.7 | 1.4 | 1.1 | 1.2 | 1.3 | 0.8 | -0.8 | -0.9 | -0.4 | 1.1 | 0.8 | 1.1 | 0.9 | 1.4 | 1.5 | 1.4 | -0.4 | 0.8 |
Conditioned reinforcement - actives | 1.0 | 1.0 | 3.8 | -1.8 | 0.6 | -1.6 | 0.1 | -1.5 | 0.3 | 0.1 | -2.0 | -0.2 | -1.3 | 0.2 | 0.3 | -0.1 | 1.1 | -0.0 | 0.4 | -1.6 | 0.1 | -1.6 | 0.3 | -1.3 | -0.8 | 0.5 |
Conditioned reinforcement - inactives | 0.6 | 0.7 | 1.5 | -0.7 | 1.1 | 0.1 | 1.0 | 0.4 | 1.1 | 0.3 | -0.1 | 1.1 | 0.4 | 1.0 | -1.0 | -1.1 | 0.5 | 1.1 | 1.1 | -0.0 | 1.0 | 0.1 | 1.2 | 0.2 | -0.9 | 1.0 |
Conditioned locomotion | 0.9 | 1.1 | 3.8 | -1.6 | 0.2 | -1.6 | -0.4 | -1.7 | -0.1 | -0.3 | -1.9 | -0.6 | -1.5 | -0.1 | 0.6 | 0.3 | 1.0 | -0.5 | 0.1 | -1.7 | -0.2 | -1.7 | -0.1 | -1.5 | -0.5 | 0.1 |
Intermittent access intake day 1-15 change | 2.5 | 2.5 | 4.8 | -0.6 | 1.8 | 1.0 | 1.9 | 1.5 | 1.9 | 0.1 | 0.9 | 2.1 | 1.4 | 1.8 | -2.2 | -2.2 | 0.6 | 2.2 | 1.9 | 0.7 | 2.0 | 1.0 | 1.8 | 0.9 | -1.4 | 1.8 |
Intermittent access intake escalation | 3.5 | 3.4 | 6.3 | -1.5 | 2.5 | 0.0 | 2.2 | 0.8 | 2.4 | -1.0 | -0.2 | 2.5 | 0.8 | 2.3 | -2.4 | -2.4 | 1.7 | 2.3 | 2.4 | -0.3 | 2.2 | 0.1 | 2.2 | 0.0 | -2.2 | 2.3 |
Intermittent access intake escalation 2 | 1.8 | 1.8 | 3.3 | -1.2 | 1.8 | -0.5 | 1.5 | -0.0 | 1.7 | -1.0 | -0.8 | 1.7 | 0.0 | 1.5 | -1.6 | -1.6 | 1.5 | 1.5 | 1.7 | -0.8 | 1.4 | -0.4 | 1.6 | -0.5 | -1.7 | 1.7 |
Intermitt. access day 1 inactive lever presses | 1.3 | 1.4 | 3.1 | 0.8 | 0.7 | 1.3 | 1.1 | 1.8 | 0.7 | 0.0 | 1.6 | 1.5 | 1.6 | 0.9 | -1.1 | -0.9 | -0.5 | 1.1 | 0.7 | 1.5 | 1.4 | 1.7 | 1.4 | 1.6 | -0.6 | 0.7 |
Intermitt. access day 15 inactive lever presses | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | 0.0 | 0.5 | 0.2 | 0.5 | 0.0 | 0.0 | 0.5 | 0.2 | 0.4 | -0.4 | -0.4 | 0.2 | 0.5 | 0.5 | -0.0 | 0.4 | 0.1 | 0.5 | 0.1 | -0.4 | 0.5 |
Intermitt. access escalation Index | 0.1 | 0.1 | 0.4 | 0.4 | 0.0 | -0.2 | -0.1 | -0.4 | -0.1 | -0.6 | -0.7 | 0.2 | -0.4 | -0.1 | 0.1 | 0.3 | 0.1 | -0.1 | -0.1 | -0.6 | -0.2 | -0.3 | 0.1 | -0.4 | 0.0 | -0.0 |
Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.6 | -0.8 | 0.3 | -0.3 | 0.1 | -0.4 | 0.1 | 0.4 | -0.6 | 0.2 | -0.2 | 0.2 | 0.3 | 0.2 | 0.1 | 0.1 | 0.2 | -0.4 | 0.0 | -0.3 | 0.7 | -0.0 | -0.4 | 0.2 |
Intermittent access day 15 total infusions | 1.0 | 1.1 | 3.1 | -1.2 | 1.5 | -0.1 | 1.2 | 0.2 | 1.3 | -0.2 | -0.5 | 1.6 | 0.2 | 1.3 | -1.1 | -1.1 | 0.9 | 1.3 | 1.4 | -0.6 | 1.0 | -0.1 | 1.8 | -0.0 | -1.4 | 1.3 |
Intermittent access terminal intake (last 3 days) | 0.5 | 0.6 | 1.7 | -1.0 | 1.0 | -0.2 | 0.7 | -0.1 | 0.9 | -0.1 | -0.6 | 1.0 | -0.1 | 0.8 | -0.6 | -0.7 | 0.6 | 0.8 | 0.9 | -0.5 | 0.7 | -0.2 | 1.3 | -0.1 | -1.0 | 0.9 |
Intermittent access total infusions | 1.0 | 1.1 | 2.6 | -1.6 | 1.4 | -0.3 | 1.2 | 0.1 | 1.3 | 0.2 | -0.7 | 1.2 | 0.1 | 1.3 | -0.8 | -1.1 | 0.8 | 1.2 | 1.3 | -0.4 | 1.2 | -0.3 | 1.6 | -0.0 | -1.4 | 1.3 |
Intermittent access day 1 locomotion | 0.6 | 0.6 | 1.9 | -0.9 | 0.1 | -1.3 | -0.3 | -1.2 | -0.1 | -0.7 | -1.4 | -0.2 | -1.1 | -0.1 | 0.6 | 0.5 | 0.7 | -0.5 | -0.0 | -1.3 | -0.4 | -1.2 | 0.2 | -1.1 | -0.5 | -0.0 |
Intermittent access day 15 total locomotion | 2.4 | 2.5 | 4.6 | -1.1 | 1.9 | 0.6 | 2.0 | 1.3 | 2.0 | -0.3 | 0.5 | 2.1 | 1.4 | 2.0 | -2.0 | -2.0 | 0.8 | 2.1 | 2.0 | 0.7 | 1.8 | 0.8 | 2.0 | 0.8 | -1.7 | 1.9 |
Intermittent access total locomotion | 1.0 | 1.2 | 2.9 | -1.7 | 1.2 | -1.3 | 0.8 | -0.7 | 1.0 | -1.0 | -1.4 | 0.7 | -0.6 | 1.0 | -0.6 | -0.9 | 1.5 | 0.7 | 1.1 | -1.1 | 0.6 | -1.1 | 0.9 | -1.0 | -1.5 | 1.1 |
Intermittent access standard deviation | 0.9 | 1.0 | 2.4 | 0.3 | 0.6 | 1.6 | 0.9 | 1.4 | 0.7 | 1.3 | 1.1 | 1.2 | 1.1 | 0.7 | -0.7 | -0.7 | -0.8 | 1.0 | 0.5 | 1.0 | 1.1 | 1.3 | 1.4 | 1.4 | -0.3 | 0.6 |
Cocaine induced anxiety | 4.9 | 5.6 | 10.2 | 1.1 | -2.3 | -2.0 | -2.9 | -2.7 | -2.7 | -0.4 | -1.7 | -2.8 | -2.8 | -2.7 | 2.7 | 2.7 | -0.2 | -2.9 | -2.5 | -2.1 | -3.2 | -2.2 | -2.7 | -2.3 | 1.9 | -2.4 |
Post-drug Anxiety | 1.3 | 1.4 | 2.6 | 0.4 | -1.0 | -1.3 | -1.4 | -1.5 | -1.3 | -0.4 | -1.0 | -1.2 | -1.5 | -1.2 | 1.3 | 1.3 | 0.2 | -1.4 | -1.1 | -1.4 | -1.6 | -1.2 | -1.2 | -1.3 | 0.8 | -1.0 |
Baseline Anxiety | 5.1 | 5.4 | 9.8 | -0.8 | 2.4 | 1.8 | 2.7 | 2.6 | 2.5 | 0.0 | 1.9 | 3.0 | 2.7 | 2.5 | -2.7 | -2.5 | 0.4 | 2.8 | 2.5 | 2.0 | 3.1 | 2.3 | 2.8 | 2.3 | -2.0 | 2.3 |
Lifetime Intake | 1.1 | 1.3 | 3.0 | -1.7 | 1.5 | -0.4 | 1.3 | 0.0 | 1.4 | 0.2 | -0.8 | 1.3 | 0.1 | 1.4 | -0.8 | -1.2 | 0.9 | 1.3 | 1.4 | -0.5 | 1.3 | -0.3 | 1.7 | -0.1 | -1.5 | 1.5 |
Incentive Sensitization - Responses | 1.4 | 1.4 | 2.7 | -0.8 | 1.5 | 0.4 | 1.4 | 0.8 | 1.5 | -0.3 | 0.2 | 1.6 | 0.9 | 1.5 | -1.5 | -1.5 | 0.7 | 1.5 | 1.4 | 0.4 | 1.4 | 0.5 | 1.7 | 0.5 | -1.4 | 1.4 |
Incentive Sensitization - Breakpoint | 1.5 | 1.6 | 2.9 | -0.8 | 1.5 | 0.6 | 1.5 | 1.0 | 1.6 | -0.2 | 0.4 | 1.7 | 1.1 | 1.6 | -1.5 | -1.6 | 0.6 | 1.6 | 1.5 | 0.5 | 1.5 | 0.6 | 1.7 | 0.7 | -1.4 | 1.5 |
Progressive ratio test 1 active lever presses | 1.5 | 1.5 | 4.2 | -2.0 | 1.6 | -0.9 | 1.3 | -0.4 | 1.4 | -0.3 | -1.2 | 1.3 | -0.3 | 1.4 | -0.8 | -1.1 | 1.4 | 1.2 | 1.6 | -1.1 | 0.9 | -0.7 | 1.4 | -0.6 | -1.5 | 1.6 |
Progressive ratio test 1 breakpoint | 0.7 | 0.7 | 2.7 | -1.6 | 1.0 | -0.7 | 0.9 | -0.3 | 1.0 | 0.2 | -0.9 | 0.8 | -0.2 | 1.0 | -0.5 | -0.8 | 0.9 | 0.9 | 1.1 | -0.7 | 0.5 | -0.6 | 1.0 | -0.4 | -1.0 | 1.1 |
Progressive ratio test 1 inactive lever presses | 0.2 | 0.2 | 0.5 | -0.5 | 0.6 | -0.2 | 0.5 | -0.1 | 0.6 | -0.0 | -0.4 | 0.6 | -0.1 | 0.5 | -0.4 | -0.4 | 0.5 | 0.6 | 0.6 | -0.6 | 0.0 | -0.2 | 0.7 | -0.2 | -0.4 | 0.6 |
Progressive ratio test 2 active lever presses | 2.4 | 2.6 | 5.0 | -1.9 | 2.2 | -0.3 | 1.9 | 0.2 | 2.0 | -0.7 | -0.8 | 2.1 | 0.4 | 2.1 | -1.6 | -1.8 | 1.5 | 1.9 | 2.1 | -0.5 | 1.6 | -0.2 | 2.2 | -0.1 | -2.1 | 2.1 |
Progressive ratio test 2 breakpoint | 2.1 | 2.3 | 4.8 | -1.8 | 2.0 | -0.2 | 1.8 | 0.3 | 1.9 | -0.5 | -0.6 | 2.0 | 0.5 | 2.0 | -1.5 | -1.7 | 1.3 | 1.8 | 2.0 | -0.4 | 1.5 | -0.1 | 2.2 | 0.1 | -2.0 | 2.0 |
Progressive ratio test 2 inactive lever presses | 0.8 | 1.0 | 2.4 | -0.2 | 1.1 | 0.9 | 1.2 | 1.0 | 1.2 | 0.2 | 0.4 | 1.4 | 0.9 | 1.1 | -1.2 | -1.1 | 0.0 | 1.2 | 1.0 | 0.6 | 1.2 | 0.7 | 1.5 | 0.8 | -0.9 | 1.0 |
Total sessions with >9 infusions | 5.8 | 6.4 | 11.3 | -3.1 | 3.4 | -1.1 | 3.0 | 0.2 | 3.2 | -1.1 | -1.2 | 2.8 | 0.5 | 3.2 | -2.6 | -3.1 | 2.7 | 3.0 | 3.3 | -0.9 | 3.0 | -0.6 | 2.9 | -0.5 | -3.4 | 3.4 |
Short access day 1 total inactive lever presses | 0.2 | 0.2 | 1.0 | 0.1 | 0.6 | 0.1 | 0.5 | 0.2 | 0.4 | -0.7 | -0.2 | 0.9 | -0.0 | 0.5 | -0.4 | -0.1 | 0.3 | 0.6 | 0.5 | -0.5 | 0.1 | 0.1 | 1.0 | -0.0 | -0.4 | 0.6 |
Short access day 10 total inactive lever presses | 0.6 | 0.7 | 1.3 | -0.1 | 0.8 | 0.7 | 0.9 | 1.1 | 0.9 | -0.0 | 0.7 | 1.0 | 1.1 | 0.8 | -1.1 | -1.0 | 0.1 | 1.0 | 0.8 | 0.9 | 1.1 | 0.8 | 0.8 | 0.8 | -0.6 | 0.7 |
Short access day 1 total infusions | 1.0 | 1.0 | 1.8 | -1.3 | 1.2 | -1.0 | 0.9 | -0.5 | 1.1 | -0.7 | -1.2 | 0.9 | -0.5 | 1.1 | -0.6 | -0.8 | 1.3 | 1.0 | 1.1 | -1.2 | 0.8 | -0.9 | 1.1 | -0.9 | -1.3 | 1.3 |
Short access day 10 total infusions | 0.6 | 0.7 | 2.8 | -1.7 | 0.8 | -1.0 | 0.6 | -0.7 | 0.7 | 0.2 | -1.2 | 0.4 | -0.6 | 0.7 | -0.1 | -0.5 | 0.9 | 0.5 | 0.8 | -1.1 | 0.4 | -0.9 | 0.8 | -0.7 | -0.9 | 0.9 |
Short access total infusions | 0.9 | 1.0 | 3.2 | -1.8 | 1.2 | -0.9 | 0.9 | -0.6 | 1.0 | -0.0 | -1.3 | 0.8 | -0.5 | 1.1 | -0.4 | -0.7 | 1.1 | 0.9 | 1.1 | -1.1 | 0.8 | -0.9 | 1.3 | -0.6 | -1.3 | 1.3 |
Short access day 1 locomotion | 0.9 | 0.9 | 2.9 | -1.7 | 1.3 | -0.7 | 1.0 | -0.2 | 1.1 | 0.0 | -0.9 | 0.8 | -0.0 | 1.2 | -0.7 | -1.0 | 1.1 | 1.1 | 1.3 | -0.7 | 0.8 | -0.5 | 1.0 | -0.3 | -1.1 | 1.3 |
Short access day 10 total locomotion | 0.6 | 0.7 | 1.8 | -0.5 | 1.0 | -0.9 | 0.7 | -0.3 | 0.9 | -1.3 | -0.5 | 0.8 | -0.2 | 0.8 | -0.8 | -0.8 | 1.3 | 0.7 | 0.9 | -0.7 | 0.4 | -0.5 | 0.7 | -0.6 | -1.1 | 0.9 |
Short access total locomotion | 1.7 | 1.8 | 3.9 | -1.9 | 1.4 | -1.9 | 0.8 | -1.3 | 1.1 | -1.2 | -1.8 | 0.7 | -1.0 | 1.0 | -0.5 | -0.9 | 2.0 | 0.7 | 1.2 | -1.7 | 0.6 | -1.5 | 1.0 | -1.5 | -1.8 | 1.3 |
Compulsive drug intake | 0.5 | 0.5 | 1.1 | 0.9 | -0.8 | 0.8 | -0.5 | 0.5 | -0.7 | 0.7 | 0.9 | -0.5 | 0.2 | -0.7 | 0.6 | 0.8 | -1.0 | -0.5 | -0.7 | 0.6 | -0.3 | 0.7 | -0.4 | 0.7 | 1.0 | -0.7 |
One hour access (0.3 mA shock) | 1.3 | 1.5 | 4.1 | -0.3 | 1.2 | 1.3 | 1.4 | 1.4 | 1.2 | 0.8 | 0.8 | 1.8 | 1.2 | 1.3 | -1.2 | -1.1 | -0.4 | 1.5 | 1.2 | 0.8 | 1.2 | 1.2 | 2.0 | 1.3 | -0.8 | 1.2 |
One hour access (shock baseline) | 1.7 | 2.0 | 3.9 | -1.5 | 1.9 | -0.1 | 1.7 | 0.5 | 1.8 | -0.2 | -0.4 | 1.9 | 0.6 | 1.8 | -1.6 | -1.7 | 1.1 | 1.7 | 1.8 | -0.2 | 1.6 | 0.0 | 2.0 | 0.2 | -1.8 | 1.7 |
Number of responses in last shaping day | 0.2 | 0.2 | 0.6 | -0.7 | 0.5 | -0.6 | 0.3 | -0.3 | 0.4 | -0.1 | -0.8 | 0.2 | -0.4 | 0.3 | -0.2 | -0.4 | 0.5 | 0.2 | 0.5 | -0.6 | 0.4 | -0.6 | 0.3 | -0.5 | -0.6 | 0.3 |
Context. condit. distance diff. score | 1.3 | 1.5 | 3.0 | 1.2 | -1.2 | -0.9 | -1.6 | -1.2 | -1.4 | -1.1 | -0.7 | -1.1 | -1.3 | -1.5 | 1.2 | 1.5 | -0.0 | -1.5 | -1.3 | -1.1 | -1.7 | -0.9 | -1.3 | -1.1 | 1.1 | -1.3 |
Locomotion velocity, session 1 | 0.2 | 0.2 | 1.0 | -0.9 | -0.3 | -0.4 | -0.0 | -0.3 | -0.1 | 1.0 | -0.3 | -0.8 | -0.3 | -0.1 | 0.5 | 0.1 | -0.1 | -0.1 | -0.2 | -0.0 | -0.0 | -0.4 | -0.8 | -0.2 | 0.3 | -0.0 |
Locomotion distance, session 1 | 0.9 | 1.1 | 4.2 | -2.1 | 0.7 | -1.6 | 0.7 | -1.1 | 0.9 | -1.2 | -1.5 | 0.0 | -0.8 | 0.9 | -0.2 | -0.5 | 1.6 | 0.5 | 0.8 | -1.2 | 0.5 | -1.4 | -0.1 | -1.3 | -1.0 | 1.1 |
Locomotion velocity, session 2 | 1.2 | 1.4 | 4.4 | -1.6 | 0.6 | -2.1 | 0.1 | -1.5 | 0.6 | -1.6 | -1.7 | -0.1 | -1.3 | 0.3 | -0.1 | -0.3 | 1.8 | -0.0 | 0.5 | -1.8 | 0.1 | -1.9 | -0.2 | -1.8 | -0.9 | 0.6 |
Locomotion distance, session 2 | 1.2 | 1.7 | 3.7 | -1.8 | 1.8 | -1.2 | 1.2 | -0.5 | 1.4 | -0.8 | -1.2 | 1.2 | -0.4 | 1.5 | -1.0 | -1.2 | 1.8 | 1.1 | 1.6 | -1.0 | 1.4 | -0.8 | 1.5 | -0.7 | -1.9 | 1.6 |
Locomotion velocity, session 3 | 0.8 | 0.9 | 2.4 | -1.5 | 0.8 | -1.4 | 0.4 | -1.0 | 0.7 | -1.4 | -1.4 | 0.3 | -0.8 | 0.6 | -0.3 | -0.4 | 1.5 | 0.3 | 0.8 | -1.3 | 0.3 | -1.2 | 0.2 | -1.2 | -0.9 | 0.8 |
Locomotion distance, session 3 | 1.2 | 1.4 | 3.5 | -1.5 | 0.8 | -1.8 | 0.2 | -1.3 | 0.7 | -1.8 | -1.9 | 0.1 | -1.2 | 0.4 | -0.3 | -0.3 | 1.8 | 0.1 | 0.7 | -1.9 | -0.0 | -1.6 | 0.1 | -1.7 | -0.9 | 0.7 |
Stereotopy head waving bouts, day 3 | 0.2 | 0.2 | 0.5 | -0.6 | 0.5 | 0.5 | 0.5 | 0.4 | 0.6 | 0.7 | 0.1 | 0.3 | 0.5 | 0.6 | -0.5 | -0.7 | 0.1 | 0.7 | 0.6 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | -0.2 | 0.6 |
Stereotopy head waving duration, day 3 | 0.2 | 0.3 | 1.5 | -0.2 | -0.3 | 1.0 | 0.2 | 0.6 | 0.1 | 1.2 | 0.7 | -0.3 | 0.7 | 0.1 | -0.1 | -0.3 | -0.7 | 0.2 | -0.1 | 0.9 | 0.1 | 0.6 | -0.4 | 0.7 | 0.5 | -0.0 |
Locomotion velocity, session 7 | 0.1 | 0.1 | 0.3 | 0.3 | 0.2 | 0.4 | 0.1 | 0.4 | 0.2 | -0.3 | 0.5 | 0.4 | 0.4 | 0.1 | -0.3 | -0.2 | -0.2 | 0.1 | 0.1 | 0.4 | 0.4 | 0.4 | 0.5 | 0.4 | -0.3 | -0.0 |
Locomotion distance, session 7 | 0.1 | 0.2 | 0.5 | 0.5 | -0.3 | -0.4 | -0.5 | -0.5 | -0.3 | -0.7 | -0.2 | -0.3 | -0.5 | -0.5 | 0.3 | 0.4 | 0.1 | -0.7 | -0.5 | -0.4 | -0.4 | -0.4 | -0.2 | -0.4 | 0.1 | -0.6 |
Stereotopy head waving bouts, day 7 | 0.1 | 0.1 | 0.6 | 0.3 | 0.1 | 0.5 | 0.0 | 0.3 | -0.0 | 0.8 | 0.3 | 0.2 | 0.2 | -0.1 | -0.1 | -0.1 | -0.3 | 0.2 | 0.0 | 0.3 | 0.1 | 0.3 | 0.3 | 0.3 | -0.1 | -0.0 |
Stereotopy head waving duration, day 7 | 0.6 | 0.8 | 1.3 | 0.0 | 0.8 | 1.0 | 1.0 | 1.1 | 0.8 | 0.7 | 0.8 | 1.0 | 1.1 | 0.9 | -0.8 | -0.9 | -0.2 | 1.1 | 0.8 | 1.0 | 1.0 | 0.9 | 1.1 | 0.9 | -0.7 | 0.8 |
Locomotion velocity, session 8 | 2.1 | 2.5 | 4.2 | 1.2 | -1.8 | -0.9 | -1.9 | -1.4 | -1.9 | -0.8 | -0.7 | -1.9 | -1.6 | -1.9 | 1.9 | 2.1 | -0.6 | -1.9 | -1.9 | -1.0 | -2.0 | -1.0 | -1.8 | -1.1 | 1.5 | -1.7 |
Locomotion distance, session 8 | 1.1 | 1.7 | 3.7 | 0.3 | -0.7 | -1.8 | -1.2 | -1.9 | -1.0 | -1.6 | -1.6 | -1.0 | -1.9 | -1.0 | 1.1 | 1.2 | 0.7 | -1.2 | -0.8 | -1.9 | -1.2 | -1.6 | -0.9 | -1.7 | 0.3 | -0.7 |
Degree of sensitization distance | 1.9 | 1.9 | 5.6 | 2.4 | -1.6 | 1.4 | -1.2 | 0.5 | -1.6 | 1.6 | 1.5 | -0.9 | 0.3 | -1.4 | 1.2 | 1.3 | -2.0 | -1.2 | -1.7 | 1.2 | -1.0 | 1.1 | -0.8 | 1.1 | 1.7 | -1.7 |
Degree of sensitization stereotypy | 0.1 | 0.1 | 0.5 | 0.7 | -0.1 | 0.6 | -0.1 | 0.4 | -0.3 | 0.7 | 0.4 | 0.1 | 0.2 | -0.2 | 0.1 | 0.1 | -0.6 | 0.0 | -0.2 | 0.5 | 0.1 | 0.4 | 0.3 | 0.5 | 0.0 | -0.2 |
Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.9 | -1.0 | 0.3 | -0.6 | 0.2 | -0.3 | 0.3 | 0.2 | -0.3 | -0.1 | -0.2 | 0.4 | -0.1 | -0.2 | 0.5 | 0.1 | 0.4 | -0.5 | 0.2 | -0.4 | -0.2 | -0.4 | -0.2 | 0.4 |
Condit. Reinf. active-inactive response ratio | 0.0 | 0.0 | 0.3 | -0.5 | -0.2 | -0.2 | 0.1 | -0.1 | -0.1 | -0.2 | -0.0 | -0.2 | -0.1 | 0.1 | 0.2 | 0.2 | 0.0 | -0.1 | 0.0 | -0.1 | -0.1 | -0.1 | -0.3 | -0.1 | 0.1 | 0.1 |
Condit. Reinf. active responses | 0.8 | 1.0 | 2.0 | -1.4 | 1.2 | 0.1 | 1.3 | 0.6 | 1.3 | 0.6 | 0.3 | 0.9 | 0.9 | 1.4 | -1.1 | -1.3 | 0.6 | 1.2 | 1.3 | 0.5 | 1.3 | 0.4 | 0.8 | 0.5 | -1.0 | 1.3 |
Condit. Reinf. inactive responses | 1.6 | 1.9 | 3.6 | -1.2 | 1.5 | 0.8 | 1.7 | 1.3 | 1.7 | 1.2 | 0.8 | 1.2 | 1.5 | 1.6 | -1.5 | -1.9 | 0.4 | 1.7 | 1.5 | 1.2 | 1.8 | 1.0 | 1.2 | 1.1 | -1.2 | 1.5 |
Incentive salience index mean | 0.3 | 0.3 | 1.9 | -1.4 | 0.2 | -1.0 | 0.2 | -0.7 | 0.2 | 0.1 | -0.8 | -0.4 | -0.6 | 0.3 | 0.2 | -0.1 | 0.6 | -0.0 | 0.3 | -0.7 | 0.1 | -0.8 | -0.4 | -0.7 | -0.2 | 0.3 |
Condit. Reinf. lever presses | 0.2 | 0.2 | 2.0 | -1.4 | 0.2 | -0.7 | 0.4 | -0.3 | 0.4 | 0.3 | -0.6 | -0.2 | -0.3 | 0.4 | 0.1 | -0.2 | 0.4 | 0.2 | 0.3 | -0.3 | 0.3 | -0.6 | -0.3 | -0.4 | -0.3 | 0.5 |
Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 1.4 | -0.6 | -0.0 | -0.4 | 0.2 | -0.2 | 0.4 | -1.2 | -0.2 | -0.1 | -0.1 | 0.3 | -0.2 | -0.2 | 0.5 | -0.0 | 0.1 | -0.2 | 0.4 | -0.5 | -0.3 | -0.5 | -0.3 | 0.2 |
Time in novel zone, hab. session 1 | 0.6 | 0.5 | 1.5 | 0.8 | 0.4 | 1.1 | 0.3 | 1.0 | 0.1 | 1.2 | 1.0 | 0.7 | 0.9 | 0.2 | -0.4 | -0.3 | -0.6 | 0.6 | 0.2 | 0.9 | 0.4 | 1.2 | 0.9 | 1.2 | 0.0 | 0.1 |
Total zone transitions, hab. session 1 | 1.1 | 1.6 | 3.2 | -1.2 | 1.8 | -0.7 | 1.4 | -0.0 | 1.5 | -0.7 | -0.5 | 1.5 | 0.1 | 1.5 | -1.4 | -1.5 | 1.5 | 1.4 | 1.6 | -0.6 | 1.4 | -0.3 | 1.6 | -0.4 | -1.8 | 1.7 |
Total locomotion distance, hab. session 1 | 0.1 | 0.1 | 1.1 | 0.1 | 0.2 | -0.3 | -0.1 | -0.3 | -0.1 | 1.1 | -0.3 | -0.0 | -0.4 | -0.2 | -0.0 | -0.1 | 0.2 | 0.1 | 0.0 | -0.5 | -0.1 | -0.2 | -0.0 | -0.2 | 0.1 | 0.0 |
Locomotion velocity, hab. session 1 | 0.1 | 0.2 | 1.0 | 0.1 | 0.0 | -0.6 | -0.3 | -0.6 | -0.2 | 1.0 | -0.6 | -0.2 | -0.7 | -0.3 | 0.2 | 0.1 | 0.2 | -0.2 | -0.2 | -0.8 | -0.3 | -0.4 | -0.3 | -0.5 | 0.2 | -0.1 |
Time in familiar zone, hab. session 2 | 1.7 | 1.8 | 5.0 | 0.6 | 0.4 | 2.2 | 1.1 | 2.0 | 0.6 | 1.2 | 1.8 | 1.1 | 1.8 | 0.9 | -1.0 | -0.7 | -1.2 | 1.0 | 0.6 | 1.8 | 1.2 | 2.1 | 1.1 | 2.0 | -0.1 | 0.6 |
Time in novel zone, hab. session 2 | 1.0 | 1.0 | 3.6 | -1.2 | 0.3 | -1.9 | -0.3 | -1.5 | 0.2 | -1.3 | -1.6 | -0.3 | -1.2 | -0.1 | 0.2 | -0.1 | 1.5 | -0.3 | 0.2 | -1.5 | -0.3 | -1.7 | -0.4 | -1.6 | -0.6 | 0.1 |
Total zone transitions, hab. session 2 | 1.3 | 1.7 | 3.3 | -1.2 | 1.8 | -0.7 | 1.6 | 0.1 | 1.5 | -0.9 | -0.3 | 1.7 | 0.3 | 1.7 | -1.3 | -1.4 | 1.5 | 1.5 | 1.7 | -0.4 | 1.5 | -0.1 | 1.7 | -0.1 | -1.8 | 1.8 |
Total locomotion distance, hab. session 2 | 0.3 | 0.4 | 1.0 | -0.7 | 1.0 | -0.6 | 0.5 | -0.2 | 0.7 | -0.1 | -0.6 | 0.8 | -0.2 | 0.6 | -0.7 | -0.7 | 1.0 | 0.7 | 0.9 | -0.7 | 0.5 | -0.2 | 0.8 | -0.3 | -0.8 | 0.9 |
Locomotion velocity, hab. session 2 | 0.2 | 0.3 | 0.9 | -0.6 | 0.8 | -0.7 | 0.3 | -0.4 | 0.5 | -0.2 | -0.6 | 0.6 | -0.4 | 0.4 | -0.5 | -0.5 | 0.9 | 0.5 | 0.7 | -0.8 | 0.3 | -0.4 | 0.6 | -0.5 | -0.7 | 0.7 |
Novel to familiar place preference ratio | 0.3 | 0.3 | 0.9 | 0.6 | -0.3 | 0.6 | -0.0 | 0.7 | -0.2 | 0.8 | 0.9 | 0.2 | 0.7 | -0.2 | 0.0 | 0.1 | -0.7 | 0.1 | -0.2 | 0.9 | -0.1 | 0.8 | 0.1 | 0.8 | 0.4 | -0.3 |
Novelty place preference | 0.3 | 0.3 | 0.8 | 0.5 | -0.1 | 0.7 | 0.1 | 0.8 | -0.1 | 0.8 | 0.9 | 0.4 | 0.7 | -0.0 | -0.1 | -0.1 | -0.7 | 0.2 | -0.1 | 0.9 | -0.0 | 0.8 | 0.3 | 0.9 | 0.2 | -0.2 |
Time in novel zone, NPP test | 0.6 | 0.7 | 1.8 | 0.7 | 0.1 | 1.1 | 0.4 | 1.3 | 0.1 | 1.0 | 1.3 | 0.7 | 1.2 | 0.2 | -0.4 | -0.3 | -0.9 | 0.5 | 0.1 | 1.3 | 0.3 | 1.3 | 0.7 | 1.4 | 0.1 | -0.0 |
Total zone transitions, NPP test | 0.3 | 0.5 | 1.7 | -0.3 | 1.0 | -0.6 | 0.8 | -0.2 | 0.5 | -0.6 | -0.4 | 1.1 | -0.2 | 0.8 | -0.4 | -0.3 | 0.8 | 0.7 | 0.8 | -0.6 | 0.7 | -0.1 | 1.3 | -0.2 | -1.1 | 0.9 |
Total locomotion distance, NPP test | 0.1 | 0.1 | 0.5 | 0.1 | 0.5 | -0.5 | 0.1 | -0.3 | -0.1 | 0.2 | -0.4 | 0.5 | -0.5 | 0.1 | -0.1 | 0.0 | 0.4 | 0.2 | 0.3 | -0.7 | -0.0 | -0.1 | 0.6 | -0.2 | -0.3 | 0.3 |
Locomotion velocity, NPP test | 0.2 | 0.3 | 1.6 | 0.0 | 0.2 | -1.0 | -0.3 | -1.0 | -0.4 | -0.2 | -0.9 | 0.0 | -1.1 | -0.2 | 0.3 | 0.4 | 0.6 | -0.2 | -0.0 | -1.3 | -0.4 | -0.7 | 0.1 | -0.8 | -0.2 | 0.1 |
Pavlov. Cond. lever latency | 0.3 | 0.3 | 1.4 | 0.6 | -0.1 | 1.2 | 0.3 | 0.9 | -0.0 | 0.4 | 0.8 | 0.3 | 0.8 | 0.1 | -0.2 | -0.0 | -0.8 | 0.2 | -0.1 | 0.9 | 0.2 | 0.9 | 0.3 | 0.9 | 0.3 | -0.0 |
Pavlov. Cond. magazine entry latency | 0.1 | 0.2 | 0.4 | -0.3 | 0.6 | -0.2 | 0.3 | -0.3 | 0.4 | 0.2 | -0.4 | 0.5 | -0.2 | 0.3 | -0.4 | -0.4 | 0.5 | 0.4 | 0.5 | -0.6 | 0.2 | -0.2 | 0.6 | -0.3 | -0.5 | 0.5 |
Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.4 | 0.0 | 0.1 | -0.6 | -0.1 | -0.4 | 0.0 | -0.4 | -0.3 | 0.1 | -0.3 | -0.0 | -0.0 | -0.0 | 0.5 | -0.0 | 0.1 | -0.4 | -0.1 | -0.3 | -0.0 | -0.4 | -0.3 | 0.0 |
Pavlov. Cond. index score | 0.2 | 0.2 | 0.5 | -0.4 | 0.6 | -0.5 | 0.3 | -0.2 | 0.5 | -0.4 | -0.3 | 0.5 | -0.1 | 0.4 | -0.5 | -0.4 | 0.7 | 0.4 | 0.6 | -0.5 | 0.3 | -0.2 | 0.5 | -0.3 | -0.6 | 0.5 |
Pavlov. Cond. latency score | 0.1 | 0.2 | 0.5 | -0.4 | 0.5 | -0.6 | 0.2 | -0.3 | 0.4 | -0.4 | -0.3 | 0.4 | -0.2 | 0.3 | -0.4 | -0.4 | 0.7 | 0.3 | 0.5 | -0.5 | 0.3 | -0.3 | 0.4 | -0.4 | -0.6 | 0.4 |
Pavlov. Cond. lever contacts | 0.0 | 0.1 | 0.3 | -0.5 | 0.1 | -0.5 | -0.0 | -0.2 | 0.2 | -0.1 | -0.2 | -0.1 | -0.2 | 0.1 | -0.1 | -0.2 | 0.4 | 0.0 | 0.2 | -0.2 | 0.1 | -0.3 | -0.1 | -0.3 | -0.2 | 0.1 |
Pavlov. Cond. magazine entry number | 0.7 | 0.9 | 1.8 | 0.8 | -1.3 | 0.2 | -1.1 | -0.2 | -1.3 | 0.5 | 0.1 | -1.3 | -0.3 | -1.1 | 1.2 | 1.2 | -1.1 | -1.2 | -1.3 | 0.3 | -1.0 | -0.1 | -1.2 | 0.1 | 1.2 | -1.3 |
Pavlov. Cond. intertrial magazine entries | 0.2 | 0.2 | 0.7 | -0.9 | 0.6 | -0.2 | 0.5 | 0.1 | 0.5 | 0.1 | -0.2 | 0.3 | 0.2 | 0.6 | -0.5 | -0.7 | 0.4 | 0.5 | 0.6 | 0.1 | 0.6 | -0.0 | 0.2 | 0.0 | -0.6 | 0.6 |
Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.3 | -0.3 | 0.5 | -0.3 | 0.3 | -0.1 | 0.5 | -0.2 | -0.1 | 0.5 | 0.0 | 0.3 | -0.4 | -0.4 | 0.5 | 0.4 | 0.5 | -0.3 | 0.3 | -0.1 | 0.5 | -0.1 | -0.5 | 0.4 |
Pavlov. Cond. response bias | 0.3 | 0.4 | 0.9 | -0.8 | 0.8 | -0.6 | 0.5 | -0.3 | 0.8 | -0.3 | -0.5 | 0.6 | -0.2 | 0.6 | -0.6 | -0.7 | 1.0 | 0.6 | 0.8 | -0.6 | 0.4 | -0.4 | 0.6 | -0.5 | -0.8 | 0.7 |
Bone: apparent density | 1.4 | 2.3 | 5.6 | 0.9 | 0.6 | 2.2 | 1.2 | 2.4 | 0.7 | -0.1 | 2.1 | 1.7 | 2.2 | 1.0 | -1.2 | -0.7 | -1.1 | 0.9 | 0.8 | 2.2 | 1.5 | 2.3 | 1.8 | 2.3 | -0.6 | 0.5 |
Bone surface | 0.4 | 0.7 | 1.8 | 0.7 | 0.4 | 1.2 | 0.5 | 1.2 | 0.3 | -0.6 | 1.1 | 1.1 | 1.2 | 0.5 | -0.7 | -0.4 | -0.5 | 0.4 | 0.5 | 1.3 | 0.7 | 1.3 | 1.3 | 1.2 | -0.6 | 0.2 |
Bone volume | 1.6 | 2.8 | 6.2 | 0.5 | 1.3 | 1.8 | 1.6 | 2.2 | 1.2 | -0.8 | 1.8 | 2.3 | 2.2 | 1.6 | -1.7 | -1.2 | -0.4 | 1.4 | 1.4 | 1.9 | 1.9 | 2.1 | 2.5 | 2.0 | -1.4 | 1.0 |
Bone: connectivity density | 0.3 | 0.5 | 1.2 | 1.0 | -0.6 | 1.0 | -0.4 | 0.8 | -0.5 | -0.1 | 1.0 | -0.1 | 0.7 | -0.4 | 0.1 | 0.4 | -1.0 | -0.5 | -0.5 | 1.1 | -0.1 | 0.9 | -0.1 | 0.9 | 0.5 | -0.7 |
Bone: cortical apparent density | 2.1 | 2.7 | 7.3 | -2.2 | 0.7 | -2.7 | 0.0 | -2.1 | 0.7 | -2.1 | -2.7 | -0.3 | -1.9 | 0.3 | -0.1 | -0.4 | 2.5 | 0.0 | 0.7 | -2.6 | -0.2 | -2.7 | -0.7 | -2.7 | -1.1 | 0.8 |
Bone: cortical area | 7.0 | 10.6 | 21.2 | -1.0 | 3.7 | 1.9 | 3.9 | 3.2 | 3.5 | -0.7 | 2.1 | 4.5 | 3.4 | 3.8 | -3.9 | -3.6 | 1.1 | 3.8 | 3.7 | 2.3 | 3.8 | 2.7 | 4.6 | 2.6 | -3.4 | 3.5 |
Bone: cortical porosity | 0.3 | 0.3 | 0.9 | 0.5 | -0.2 | 1.0 | -0.2 | 0.7 | -0.3 | 0.4 | 0.8 | 0.2 | 0.5 | -0.2 | 0.1 | 0.3 | -0.9 | -0.2 | -0.2 | 0.7 | 0.0 | 0.8 | 0.4 | 0.9 | 0.3 | -0.4 |
Bone: cortical porosity | 0.5 | 0.6 | 1.7 | 1.1 | -0.3 | 1.3 | -0.3 | 0.9 | -0.5 | 0.4 | 1.1 | 0.4 | 0.7 | -0.3 | 0.1 | 0.5 | -1.2 | -0.3 | -0.3 | 1.0 | -0.1 | 1.2 | 0.6 | 1.2 | 0.4 | -0.6 |
Bone: cortical thickness | 3.8 | 6.3 | 12.5 | -1.3 | 3.1 | 0.9 | 3.1 | 2.0 | 3.0 | -0.9 | 1.0 | 3.5 | 2.2 | 3.1 | -3.1 | -3.0 | 1.5 | 3.1 | 3.1 | 1.1 | 2.9 | 1.5 | 3.4 | 1.3 | -2.9 | 3.0 |
Bone: cortical thickness | 1.5 | 1.8 | 3.8 | -0.7 | 1.8 | -0.1 | 1.5 | 0.6 | 1.6 | -1.5 | -0.1 | 1.8 | 0.6 | 1.6 | -1.7 | -1.5 | 1.3 | 1.4 | 1.6 | -0.2 | 1.5 | 0.2 | 1.9 | 0.0 | -1.8 | 1.6 |
Bone: cortical tissue density | 2.1 | 2.8 | 7.5 | -2.1 | 0.5 | -2.7 | -0.2 | -2.3 | 0.5 | -2.0 | -2.7 | -0.5 | -2.0 | 0.1 | 0.1 | -0.2 | 2.4 | -0.2 | 0.5 | -2.7 | -0.4 | -2.7 | -0.9 | -2.7 | -0.8 | 0.6 |
Bone: elastic displacement | 0.2 | 0.2 | 0.4 | 0.6 | -0.4 | 0.3 | -0.5 | 0.1 | -0.4 | 0.6 | 0.4 | -0.3 | -0.0 | -0.6 | 0.3 | 0.4 | -0.6 | -0.3 | -0.4 | 0.2 | -0.2 | 0.3 | -0.3 | 0.3 | 0.6 | -0.5 |
Bone: elastic work | 0.8 | 1.0 | 2.2 | -0.8 | 1.4 | -0.7 | 0.9 | -0.1 | 1.1 | -1.3 | -0.5 | 1.2 | -0.0 | 1.0 | -1.1 | -1.0 | 1.4 | 0.9 | 1.3 | -0.6 | 1.0 | -0.3 | 1.3 | -0.4 | -1.5 | 1.1 |
Bone: endosteal estimation | 0.8 | 1.8 | 5.3 | 0.1 | 1.5 | 1.1 | 1.3 | 1.4 | 1.2 | -0.4 | 1.0 | 1.9 | 1.4 | 1.3 | -1.6 | -1.3 | 0.2 | 1.4 | 1.4 | 1.1 | 1.4 | 1.5 | 2.3 | 1.3 | -1.4 | 1.1 |
Bone: endosteal perimeter | 3.5 | 7.2 | 15.0 | -1.2 | 3.3 | 1.3 | 3.2 | 2.2 | 3.1 | -1.3 | 1.2 | 3.6 | 2.5 | 3.2 | -3.3 | -3.1 | 1.4 | 3.2 | 3.3 | 1.4 | 3.2 | 1.8 | 3.9 | 1.7 | -3.1 | 3.0 |
Bone: final force | 2.2 | 3.6 | 8.5 | -1.2 | 2.3 | 0.4 | 2.3 | 1.2 | 2.1 | -1.4 | 0.4 | 2.7 | 1.5 | 2.4 | -2.1 | -2.0 | 1.2 | 2.0 | 2.3 | 0.7 | 2.2 | 0.9 | 2.9 | 0.9 | -2.5 | 2.1 |
Bone: final moment | 2.1 | 3.5 | 8.9 | -1.0 | 2.3 | 0.5 | 2.3 | 1.4 | 2.0 | -1.3 | 0.5 | 2.8 | 1.5 | 2.3 | -2.1 | -1.9 | 1.1 | 1.9 | 2.3 | 0.8 | 2.2 | 1.1 | 3.0 | 1.0 | -2.5 | 2.0 |
Bone: marrow area | 0.9 | 1.8 | 5.5 | 0.2 | 1.5 | 1.1 | 1.4 | 1.4 | 1.2 | -0.5 | 1.0 | 1.9 | 1.5 | 1.3 | -1.6 | -1.3 | 0.2 | 1.4 | 1.4 | 1.2 | 1.4 | 1.5 | 2.3 | 1.4 | -1.5 | 1.1 |
Bone: maximum diameter | 6.0 | 11.0 | 21.5 | -0.5 | 3.5 | 2.5 | 3.8 | 3.7 | 3.4 | -0.1 | 2.7 | 4.5 | 3.8 | 3.6 | -3.9 | -3.6 | 0.6 | 3.9 | 3.6 | 2.8 | 3.7 | 3.3 | 4.6 | 3.1 | -3.1 | 3.3 |
Bone: maximum force | 2.1 | 3.6 | 8.3 | -1.1 | 2.4 | 0.4 | 2.3 | 1.3 | 2.1 | -1.5 | 0.4 | 2.7 | 1.5 | 2.4 | -2.2 | -2.0 | 1.3 | 2.0 | 2.4 | 0.6 | 2.2 | 0.9 | 2.9 | 0.8 | -2.5 | 2.1 |
Bone: maximum moment | 2.0 | 3.4 | 8.6 | -0.9 | 2.3 | 0.6 | 2.2 | 1.4 | 2.0 | -1.4 | 0.5 | 2.7 | 1.5 | 2.3 | -2.2 | -2.0 | 1.2 | 1.9 | 2.3 | 0.7 | 2.1 | 1.1 | 2.9 | 0.9 | -2.4 | 2.0 |
Bone: minimum diameter | 2.2 | 4.1 | 9.2 | 0.2 | 2.2 | 1.7 | 2.2 | 2.3 | 1.8 | -0.2 | 1.8 | 2.8 | 2.4 | 2.0 | -2.4 | -2.1 | 0.3 | 2.3 | 2.1 | 1.9 | 2.1 | 2.3 | 3.0 | 2.1 | -1.9 | 1.8 |
Bone: periosteal estimation | 3.7 | 7.6 | 18.0 | -0.5 | 3.2 | 1.7 | 3.1 | 2.7 | 2.8 | -0.9 | 1.7 | 3.9 | 2.8 | 3.1 | -3.3 | -3.0 | 0.9 | 3.2 | 3.1 | 1.9 | 3.1 | 2.4 | 4.2 | 2.2 | -3.0 | 2.8 |
Bone: periosteal perimeter | 7.9 | 13.1 | 26.1 | -1.6 | 4.3 | 1.8 | 4.4 | 3.3 | 4.1 | -1.3 | 1.9 | 4.9 | 3.5 | 4.3 | -4.3 | -4.1 | 1.6 | 4.3 | 4.3 | 2.2 | 4.3 | 2.7 | 5.1 | 2.5 | -4.0 | 4.0 |
Bone: post-yield work | 0.2 | 0.3 | 1.0 | 1.0 | -0.5 | 0.6 | -0.4 | 0.3 | -0.7 | 0.4 | 0.6 | -0.1 | 0.2 | -0.5 | 0.5 | 0.7 | -0.9 | -0.4 | -0.5 | 0.5 | -0.5 | 0.6 | 0.2 | 0.6 | 0.4 | -0.6 |
Bone: stiffness | 1.6 | 2.5 | 4.8 | -1.2 | 2.0 | 0.1 | 2.1 | 0.8 | 1.9 | -1.3 | 0.1 | 2.2 | 1.1 | 2.1 | -1.8 | -1.8 | 1.3 | 1.8 | 2.0 | 0.3 | 1.8 | 0.4 | 2.2 | 0.4 | -2.1 | 2.0 |
Bone: tissue strength | 0.3 | 0.3 | 0.7 | 0.6 | -0.7 | 0.5 | -0.7 | 0.1 | -0.7 | 0.4 | 0.3 | -0.5 | -0.0 | -0.7 | 0.6 | 0.7 | -0.7 | -0.7 | -0.6 | 0.3 | -0.5 | 0.2 | -0.5 | 0.3 | 0.7 | -0.8 |
Bone: trabecular number | 0.8 | 1.3 | 3.9 | 1.3 | -0.3 | 1.9 | 0.2 | 1.8 | -0.2 | 0.2 | 1.8 | 0.6 | 1.6 | 0.0 | -0.2 | 0.2 | -1.5 | 0.0 | -0.1 | 2.0 | 0.7 | 1.9 | 0.7 | 1.9 | 0.2 | -0.5 |
Bone: trabecular spacing | 0.0 | 0.0 | 0.5 | 0.2 | -0.2 | -0.1 | 0.0 | -0.0 | 0.0 | 0.7 | 0.3 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 | -0.1 | 0.1 | -0.2 | 0.0 | -0.3 | 0.0 | -0.3 | 0.1 | 0.4 | -0.0 |
Bone: trabecular thickness | 3.7 | 4.5 | 8.1 | -0.1 | 2.0 | 2.0 | 2.3 | 2.6 | 1.9 | 0.3 | 2.0 | 2.7 | 2.6 | 2.1 | -2.5 | -2.2 | -0.1 | 2.2 | 2.1 | 2.1 | 2.6 | 2.4 | 2.8 | 2.3 | -1.7 | 1.7 |
Bone: trabecular tissue density | 1.0 | 1.4 | 3.1 | -1.7 | 1.4 | -1.1 | 1.1 | -0.3 | 1.3 | -1.5 | -1.0 | 1.1 | -0.1 | 1.3 | -1.1 | -1.2 | 1.8 | 1.1 | 1.5 | -0.8 | 0.9 | -0.7 | 0.9 | -0.7 | -1.5 | 1.5 |
Breakpoint value in progressive ratio session | 0.5 | 0.6 | 2.0 | 1.4 | -0.7 | 1.0 | -0.4 | 0.5 | -0.8 | 0.7 | 0.8 | 0.1 | 0.4 | -0.5 | 0.7 | 0.9 | -1.2 | -0.3 | -0.8 | 0.7 | -0.9 | 1.0 | 0.3 | 1.0 | 0.8 | -0.5 |
Distance traveled before self-admin | 0.6 | 0.6 | 2.2 | -0.2 | -0.0 | -1.1 | -0.4 | -1.1 | -0.0 | -0.7 | -1.1 | -0.5 | -1.3 | -0.4 | 0.0 | 0.0 | 0.9 | -0.3 | -0.2 | -1.4 | -0.7 | -1.3 | -0.6 | -1.5 | -0.0 | -0.1 |
Distance traveled after self-admin | 1.1 | 1.2 | 4.1 | -0.7 | 0.7 | -1.7 | -0.3 | -1.4 | 0.0 | -1.8 | -1.8 | 0.3 | -1.6 | -0.1 | -0.0 | 0.1 | 1.5 | -0.2 | 0.4 | -2.0 | -0.1 | -1.6 | 0.4 | -1.7 | -0.9 | 0.2 |
Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 1.0 | -0.5 | 0.2 | -0.7 | -0.1 | -0.8 | 0.1 | 0.2 | -1.0 | -0.2 | -0.7 | -0.1 | 0.1 | -0.1 | 0.6 | -0.1 | 0.0 | -1.0 | -0.1 | -0.8 | -0.1 | -0.8 | -0.1 | 0.2 |
Delta time in open arm before/after self-admin | 0.3 | 0.3 | 1.1 | 0.4 | 0.1 | 0.9 | 0.4 | 0.8 | 0.1 | 0.5 | 0.8 | 0.4 | 0.9 | 0.3 | -0.0 | -0.0 | -0.6 | 0.3 | 0.1 | 1.0 | 0.4 | 1.0 | 0.4 | 1.0 | 0.0 | 0.1 |
Diff in mean of infusions in LGA sessions | 3.4 | 3.8 | 6.8 | 2.5 | -2.6 | 0.6 | -2.2 | -0.6 | -2.5 | 1.6 | 0.7 | -2.2 | -0.6 | -2.4 | 2.3 | 2.3 | -2.0 | -2.3 | -2.6 | 0.4 | -2.4 | 0.3 | -2.1 | 0.2 | 2.6 | -2.4 |
Extinction: sum of active levers before priming | 0.8 | 0.8 | 1.7 | 0.8 | -1.1 | 0.6 | -0.8 | -0.1 | -1.1 | 1.0 | 0.3 | -0.9 | -0.1 | -1.1 | 1.1 | 1.3 | -1.1 | -0.9 | -1.1 | 0.1 | -1.3 | 0.3 | -0.7 | 0.4 | 1.3 | -0.9 |
Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.5 | -0.3 | 0.3 | 0.2 | 0.4 | 0.3 | 0.3 | -0.1 | 0.0 | 0.7 | 0.2 | 0.4 | -0.3 | -0.0 | 0.1 | 0.5 | 0.4 | -0.2 | 0.1 | 0.3 | 0.5 | 0.2 | -0.0 | 0.4 |
Delta distance traveled before/after self-admin | 0.4 | 0.5 | 2.5 | -0.4 | 0.7 | -0.7 | 0.1 | -0.4 | 0.0 | -1.6 | -0.8 | 1.0 | -0.4 | 0.4 | -0.1 | 0.2 | 0.8 | 0.1 | 0.6 | -0.9 | 0.4 | -0.4 | 1.1 | -0.4 | -1.0 | 0.4 |
Delta ambulatory time before/after self-admin | 0.2 | 0.2 | 1.2 | 0.1 | 0.5 | 0.1 | 0.1 | 0.2 | -0.1 | -0.9 | -0.1 | 0.9 | 0.1 | 0.2 | -0.1 | 0.2 | 0.1 | 0.1 | 0.4 | -0.1 | 0.4 | 0.3 | 1.1 | 0.3 | -0.6 | 0.1 |
Time in closed arm before self-admin | 0.2 | 0.2 | 3.4 | 0.6 | -0.2 | -0.2 | -0.3 | -0.0 | -0.4 | -1.8 | 0.1 | 0.2 | -0.3 | -0.2 | 0.0 | 0.5 | 0.0 | -0.3 | -0.2 | -0.2 | -0.4 | -0.1 | 0.1 | -0.2 | -0.1 | -0.3 |
Time in closed arm after self-admin | 0.7 | 0.7 | 1.4 | 0.4 | -0.6 | -1.0 | -0.9 | -1.1 | -1.0 | -0.7 | -0.8 | -0.5 | -1.2 | -0.8 | 0.9 | 1.1 | 0.0 | -1.0 | -0.8 | -1.1 | -1.1 | -0.9 | -0.3 | -0.9 | 0.3 | -0.7 |
Time in open arm before self-admin | 1.2 | 1.2 | 2.5 | 0.7 | -1.3 | -0.0 | -1.4 | -0.7 | -1.2 | 1.6 | -0.2 | -1.5 | -0.7 | -1.4 | 1.4 | 1.1 | -0.8 | -1.2 | -1.4 | -0.3 | -1.5 | -0.3 | -1.3 | -0.3 | 1.6 | -1.2 |
Time in open arm after self-admin | 0.5 | 0.5 | 3.9 | 0.4 | -0.6 | 0.9 | -0.2 | 0.3 | -0.4 | 2.0 | 0.6 | -0.7 | 0.4 | -0.4 | 0.8 | 0.3 | -1.0 | -0.2 | -0.6 | 0.8 | -0.3 | 0.6 | -0.5 | 0.7 | 0.9 | -0.4 |
Sum of active levers in priming session hrs 5-6 | 1.7 | 1.7 | 3.4 | 0.9 | -1.8 | 0.4 | -1.6 | -0.4 | -1.6 | 0.7 | 0.0 | -1.8 | -0.7 | -1.7 | 1.5 | 1.8 | -1.2 | -1.6 | -1.7 | -0.1 | -1.5 | -0.3 | -1.5 | -0.2 | 1.7 | -1.6 |
Time to tail flick, vehicle, before self-admin | 2.5 | 2.6 | 4.2 | -0.4 | 1.5 | 1.5 | 1.9 | 1.9 | 1.9 | 0.4 | 1.4 | 1.8 | 2.0 | 1.8 | -2.0 | -2.0 | 0.1 | 2.1 | 1.6 | 1.6 | 1.7 | 1.5 | 1.6 | 1.5 | -1.2 | 1.6 |
Time to tail flick, vehicle, after self-admin | 0.5 | 0.5 | 1.5 | -1.1 | 0.8 | -0.3 | 0.9 | 0.1 | 1.1 | -0.2 | -0.3 | 0.3 | 0.3 | 0.9 | -1.0 | -1.2 | 0.9 | 0.8 | 0.9 | -0.0 | 0.9 | -0.2 | -0.0 | -0.3 | -0.7 | 0.9 |
Time to tail flick, test, before self-admin | 2.5 | 2.4 | 5.9 | -2.2 | 1.7 | -2.1 | 0.8 | -1.4 | 1.3 | -2.0 | -2.1 | 0.9 | -1.2 | 1.1 | -0.9 | -1.1 | 2.4 | 0.9 | 1.5 | -2.0 | 0.8 | -1.7 | 0.9 | -1.8 | -2.0 | 1.5 |
Time to tail flick, test, after self-admin | 1.7 | 1.7 | 3.9 | -0.6 | 1.4 | 0.8 | 1.3 | 1.4 | 1.4 | -0.5 | 0.7 | 2.0 | 1.5 | 1.4 | -1.6 | -1.5 | 0.4 | 1.4 | 1.5 | 1.0 | 1.7 | 1.2 | 1.8 | 1.2 | -1.4 | 1.1 |
Delta time to tail flick, vehicle, before/after SA | 0.1 | 0.1 | 0.3 | -0.2 | -0.0 | -0.5 | -0.1 | -0.4 | -0.0 | 0.0 | -0.6 | -0.4 | -0.3 | -0.1 | 0.1 | -0.1 | 0.4 | -0.2 | -0.0 | -0.3 | 0.0 | -0.3 | -0.5 | -0.4 | 0.1 | -0.0 |
Delta time to tail flick, test, before/after SA | 2.5 | 2.2 | 5.2 | 0.3 | 0.8 | 2.0 | 1.3 | 2.3 | 1.2 | 0.8 | 1.9 | 1.5 | 2.2 | 1.2 | -1.6 | -1.4 | -0.7 | 1.4 | 1.0 | 2.1 | 1.7 | 2.0 | 1.3 | 2.0 | -0.5 | 0.7 |
Ambulatory time before self-admin | 0.5 | 0.5 | 1.3 | -0.3 | 0.6 | -0.9 | 0.5 | -0.6 | 0.7 | -0.8 | -0.8 | 0.4 | -0.6 | 0.4 | -0.8 | -0.7 | 1.1 | 0.5 | 0.5 | -1.1 | 0.1 | -0.9 | 0.2 | -1.1 | -0.6 | 0.7 |
Ambulatory time after self-admin | 1.0 | 1.1 | 3.6 | -0.5 | 0.8 | -1.5 | -0.1 | -1.2 | 0.2 | -1.8 | -1.6 | 0.5 | -1.4 | 0.1 | -0.3 | -0.1 | 1.6 | -0.0 | 0.5 | -1.9 | -0.2 | -1.4 | 0.4 | -1.6 | -0.9 | 0.4 |
Total heroin consumption | 0.6 | 0.7 | 1.9 | 0.7 | 0.4 | 1.4 | 0.7 | 1.2 | 0.3 | 0.7 | 1.0 | 0.9 | 1.2 | 0.4 | -0.6 | -0.5 | -0.7 | 0.8 | 0.4 | 1.2 | 0.5 | 1.3 | 1.0 | 1.3 | -0.2 | 0.4 |
Area under the delay curve | 0.4 | 0.5 | 1.1 | 0.0 | 0.6 | 0.8 | 0.6 | 0.9 | 0.6 | 0.6 | 0.7 | 0.9 | 1.0 | 0.6 | -0.5 | -0.5 | -0.2 | 0.7 | 0.6 | 0.7 | 0.7 | 1.0 | 0.8 | 1.0 | -0.2 | 0.5 |
Delay disc. indifference point, 0s delay | 0.2 | 0.3 | 0.8 | -0.1 | 0.9 | -0.0 | 0.5 | 0.0 | 0.5 | 0.5 | -0.1 | 0.8 | 0.1 | 0.5 | -0.6 | -0.7 | 0.5 | 0.6 | 0.7 | -0.2 | 0.6 | 0.2 | 0.8 | 0.1 | -0.6 | 0.5 |
Delay disc. indifference point, 16s delay | 0.2 | 0.2 | 0.6 | 0.5 | -0.4 | 0.4 | -0.2 | 0.4 | -0.3 | 0.5 | 0.4 | 0.1 | 0.5 | -0.2 | 0.6 | 0.5 | -0.6 | -0.2 | -0.4 | 0.6 | -0.2 | 0.7 | -0.0 | 0.8 | 0.5 | -0.3 |
Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.5 | 0.7 | -0.4 | -0.2 | -0.7 | -0.5 | -0.6 | -0.2 | -0.2 | -0.2 | -0.5 | -0.7 | 0.5 | 0.7 | -0.2 | -0.7 | -0.5 | -0.5 | -0.7 | -0.2 | -0.1 | -0.3 | 0.4 | -0.6 |
Delay disc. indifference point, 24s delay | 1.0 | 1.0 | 3.3 | 1.0 | -0.2 | 1.5 | 0.1 | 1.6 | -0.0 | 1.0 | 1.7 | 0.7 | 1.4 | 0.0 | -0.1 | 0.1 | -1.2 | 0.3 | -0.1 | 1.6 | 0.3 | 1.7 | 0.6 | 1.8 | 0.5 | -0.3 |
Delay disc. indifference point, 4s delay | 0.3 | 0.3 | 0.7 | 0.8 | -0.6 | 0.1 | -0.6 | -0.2 | -0.8 | 0.6 | 0.2 | -0.4 | -0.2 | -0.7 | 0.8 | 0.8 | -0.6 | -0.6 | -0.7 | 0.0 | -0.6 | 0.2 | -0.4 | 0.2 | 0.8 | -0.7 |
Delay disc. indifference point, 8s delay | 3.5 | 3.6 | 6.2 | -1.4 | 2.1 | 1.2 | 2.3 | 1.8 | 2.2 | 0.5 | 0.9 | 2.3 | 2.1 | 2.2 | -2.1 | -2.3 | 0.5 | 2.4 | 2.3 | 1.4 | 2.5 | 1.5 | 2.2 | 1.6 | -1.7 | 2.1 |
Delay discount exponential model param | 0.5 | 0.5 | 1.2 | -0.1 | -0.5 | -0.8 | -0.7 | -0.9 | -0.6 | -0.5 | -0.7 | -1.0 | -1.0 | -0.6 | 0.5 | 0.5 | 0.2 | -0.7 | -0.6 | -0.8 | -0.7 | -1.0 | -0.9 | -1.1 | 0.2 | -0.5 |
Delay discount hyperbolic model param | 0.2 | 0.2 | 0.7 | -0.2 | -0.4 | -0.6 | -0.4 | -0.6 | -0.3 | -0.4 | -0.5 | -0.7 | -0.7 | -0.3 | 0.3 | 0.3 | 0.2 | -0.5 | -0.4 | -0.5 | -0.4 | -0.8 | -0.7 | -0.8 | 0.1 | -0.3 |
Fecal boli incidents, locomotor time 1 | 1.8 | 2.0 | 4.4 | -1.2 | 1.2 | 0.9 | 1.6 | 1.7 | 1.8 | 1.2 | 1.3 | 1.0 | 1.8 | 1.6 | -1.7 | -2.1 | 0.1 | 1.8 | 1.4 | 1.6 | 1.6 | 1.1 | 0.8 | 1.3 | -0.8 | 1.3 |
Change in fecal boli incidents, locomotor task | 2.4 | 2.3 | 5.3 | 1.7 | -1.8 | -0.3 | -1.9 | -1.0 | -2.1 | -0.5 | -0.3 | -1.4 | -1.3 | -1.9 | 1.9 | 2.3 | -1.0 | -2.0 | -1.9 | -0.8 | -1.9 | -0.4 | -1.3 | -0.6 | 1.5 | -1.8 |
Time >=10cm from walls, locomotor time 1 | 1.7 | 1.7 | 3.4 | 1.0 | -1.6 | 0.1 | -1.7 | -0.7 | -1.7 | 0.2 | -0.2 | -1.8 | -1.0 | -1.7 | 1.4 | 1.7 | -1.0 | -1.7 | -1.6 | -0.4 | -1.6 | -0.5 | -1.5 | -0.5 | 1.5 | -1.6 |
Bouts of movement, locomotor time 1 | 0.7 | 0.8 | 2.4 | 0.6 | 0.4 | 1.1 | 0.6 | 1.1 | 0.2 | 1.2 | 1.2 | 0.9 | 1.2 | 0.5 | -0.3 | -0.3 | -0.8 | 0.7 | 0.4 | 1.4 | 0.9 | 1.5 | 1.0 | 1.5 | -0.3 | 0.2 |
Total resting periods, locomotor time 1 | 0.4 | 0.5 | 1.4 | 0.4 | 0.4 | 0.7 | 0.4 | 0.8 | 0.1 | 0.7 | 0.8 | 0.8 | 0.8 | 0.4 | -0.2 | -0.1 | -0.5 | 0.5 | 0.4 | 1.0 | 0.8 | 1.1 | 1.0 | 1.2 | -0.4 | 0.2 |
Rest time, locomotor task time 1 | 0.5 | 0.5 | 1.3 | -1.1 | 0.8 | -0.9 | 0.4 | -0.7 | 0.6 | -0.7 | -1.0 | 0.3 | -0.4 | 0.7 | -0.2 | -0.5 | 1.0 | 0.3 | 0.7 | -0.6 | 0.8 | -0.6 | 0.5 | -0.6 | -1.1 | 0.7 |
Distance moved, locomotor task time 1 | 0.2 | 0.2 | 0.5 | 0.7 | -0.5 | 0.7 | 0.0 | 0.6 | -0.2 | -0.5 | 0.7 | 0.2 | 0.4 | -0.1 | -0.0 | 0.4 | -0.6 | -0.1 | -0.3 | 0.3 | -0.2 | 0.5 | -0.0 | 0.4 | 0.6 | -0.2 |
Vertical activity count, locomotor time 1 | 0.5 | 0.5 | 1.0 | 0.7 | -0.9 | -0.2 | -0.8 | -0.5 | -0.7 | -0.8 | -0.2 | -0.7 | -0.7 | -0.9 | 0.5 | 0.8 | -0.1 | -0.9 | -0.8 | -0.7 | -1.0 | -0.5 | -0.9 | -0.7 | 0.9 | -0.8 |
Time >=10cm from walls, locomotor time 2 | 0.5 | 0.6 | 2.2 | 1.5 | -0.5 | 1.4 | -0.3 | 0.8 | -0.6 | 0.4 | 1.1 | 0.1 | 0.5 | -0.5 | 0.0 | 0.5 | -1.2 | -0.2 | -0.5 | 0.8 | -0.3 | 1.0 | 0.4 | 0.9 | 0.5 | -0.5 |
Bouts of movement, locomotor time 2 | 2.8 | 3.0 | 5.9 | 1.5 | -1.9 | -0.7 | -2.3 | -1.6 | -2.4 | -0.2 | -0.6 | -1.8 | -1.6 | -2.2 | 2.2 | 2.4 | -0.9 | -2.3 | -2.1 | -0.8 | -2.3 | -0.8 | -1.5 | -0.8 | 1.6 | -2.1 |
Total resting periods, locomotor time 2 | 1.9 | 2.0 | 4.1 | 1.2 | -1.5 | -0.7 | -1.9 | -1.5 | -2.0 | -0.3 | -0.6 | -1.4 | -1.3 | -1.8 | 1.9 | 2.0 | -0.6 | -1.9 | -1.7 | -0.8 | -1.8 | -0.7 | -1.2 | -0.6 | 1.2 | -1.7 |
Rest time, locomotor task time 2 | 0.3 | 0.3 | 0.8 | -0.8 | 0.5 | -0.6 | 0.4 | -0.3 | 0.7 | -0.9 | -0.6 | 0.3 | -0.0 | 0.5 | -0.4 | -0.6 | 0.9 | 0.4 | 0.6 | -0.4 | 0.7 | -0.4 | 0.2 | -0.4 | -0.5 | 0.6 |
Distance moved, locomotor task time 2 | 0.3 | 0.4 | 1.3 | 0.1 | 0.0 | 1.2 | 0.4 | 0.9 | 0.2 | 0.6 | 0.9 | 0.5 | 0.9 | 0.3 | -0.3 | -0.2 | -0.8 | 0.3 | 0.2 | 0.9 | 0.5 | 0.9 | 0.6 | 1.0 | 0.0 | 0.2 |
Vertical activity count, locomotor time 2 | 0.3 | 0.4 | 0.8 | 0.2 | 0.4 | 0.9 | 0.5 | 0.8 | 0.4 | 0.7 | 0.8 | 0.5 | 0.8 | 0.4 | -0.6 | -0.7 | -0.3 | 0.6 | 0.4 | 0.8 | 0.5 | 0.7 | 0.6 | 0.7 | -0.2 | 0.3 |
Weight adjusted by age | 5.7 | 6.4 | 11.1 | -1.9 | 3.1 | 0.4 | 3.1 | 1.6 | 3.1 | -2.0 | 0.2 | 3.3 | 1.8 | 3.2 | -3.1 | -3.0 | 1.8 | 3.1 | 3.2 | 0.7 | 3.3 | 0.9 | 3.0 | 0.9 | -3.0 | 3.0 |
Seeking ratio, delayed vs. immediate footshock | 0.5 | 0.6 | 1.3 | 0.3 | -0.5 | -0.9 | -0.8 | -1.1 | -0.9 | -0.0 | -0.9 | -0.6 | -1.1 | -0.7 | 0.9 | 0.9 | -0.0 | -0.8 | -0.7 | -1.0 | -0.8 | -0.8 | -0.2 | -0.8 | 0.2 | -0.6 |
Locomotion in novel chamber | 0.8 | 1.0 | 3.1 | -0.7 | 0.3 | -1.8 | -0.1 | -1.4 | 0.0 | -1.7 | -1.5 | -0.1 | -1.4 | -0.0 | 0.2 | 0.2 | 1.3 | -0.3 | 0.1 | -1.7 | -0.2 | -1.4 | 0.1 | -1.5 | -0.6 | 0.2 |
Locomotion in novel chamber post-restriction | 1.2 | 1.4 | 3.8 | -1.6 | -0.3 | -2.0 | -0.5 | -1.8 | -0.4 | -0.9 | -1.9 | -1.1 | -1.7 | -0.2 | 0.7 | 0.5 | 1.0 | -0.9 | -0.3 | -1.7 | -0.5 | -2.0 | -0.8 | -1.8 | -0.3 | -0.1 |
Progressive ratio | 0.3 | 0.4 | 1.8 | -0.1 | -0.7 | 0.0 | -0.4 | -0.4 | -0.5 | 1.3 | -0.1 | -0.8 | -0.3 | -0.5 | 0.9 | 0.6 | -0.5 | -0.5 | -0.6 | -0.2 | -0.7 | -0.2 | -0.8 | -0.1 | 0.9 | -0.4 |
Food seeking constrained by brief footshock | 0.9 | 1.1 | 2.5 | 1.0 | -1.3 | 0.8 | -1.1 | 0.5 | -1.2 | 1.1 | 1.1 | -0.7 | 0.2 | -1.3 | 0.9 | 1.2 | -1.6 | -1.1 | -1.1 | 0.6 | -1.0 | 0.7 | -0.7 | 0.8 | 1.6 | -1.3 |
Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 0.5 | 0.6 | -0.1 | 0.1 | -0.4 | 0.3 | -0.4 | -0.7 | 0.3 | 0.2 | -0.0 | -0.5 | -0.2 | 0.2 | -0.4 | -0.4 | -0.2 | 0.1 | -0.0 | 0.3 | 0.3 | 0.2 | 0.0 | -0.6 |
Run reversals in cocaine runway, females | 0.8 | 0.8 | 2.0 | -1.0 | 1.1 | -0.4 | 0.9 | 0.1 | 1.0 | -1.4 | -0.3 | 0.9 | 0.2 | 1.0 | -1.1 | -1.0 | 1.0 | 0.8 | 1.1 | -0.2 | 1.2 | -0.2 | 1.0 | -0.2 | -1.3 | 0.9 |
Run reversals in cocaine runway, males | 2.3 | 2.3 | 4.2 | 1.7 | -1.8 | -0.1 | -1.9 | -0.7 | -1.9 | 0.8 | 0.0 | -1.6 | -1.0 | -2.1 | 1.7 | 1.8 | -1.3 | -1.9 | -2.0 | -0.3 | -2.0 | -0.3 | -1.6 | -0.3 | 1.8 | -2.0 |
Latency to leave start box in cocaine runway | 0.6 | 0.6 | 1.3 | 0.2 | -1.0 | -0.5 | -1.0 | -0.8 | -0.9 | -0.5 | -0.4 | -1.1 | -0.6 | -0.9 | 0.9 | 1.1 | -0.1 | -1.1 | -0.9 | -0.5 | -0.7 | -0.4 | -1.2 | -0.4 | 1.0 | -0.9 |
Latency to leave start box in cocaine runway, F | 0.8 | 0.9 | 2.3 | 0.4 | -1.2 | -0.6 | -1.2 | -0.9 | -1.1 | -0.6 | -0.4 | -1.4 | -0.8 | -1.1 | 1.0 | 1.1 | -0.0 | -1.3 | -1.0 | -0.6 | -0.8 | -0.5 | -1.5 | -0.6 | 1.1 | -1.1 |
Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.5 | -0.4 | 0.5 | -0.2 | 0.3 | -0.1 | 0.3 | 0.0 | -0.3 | 0.5 | 0.1 | 0.4 | -0.1 | -0.2 | 0.2 | 0.3 | 0.3 | -0.2 | 0.4 | -0.0 | 0.7 | 0.1 | -0.4 | 0.4 |
Cd content in liver | 2.1 | 2.3 | 4.0 | 1.0 | -2.0 | -0.2 | -1.9 | -0.8 | -2.0 | 0.8 | -0.1 | -2.0 | -1.0 | -1.8 | 2.0 | 2.0 | -1.3 | -2.0 | -1.9 | -0.2 | -1.7 | -0.4 | -2.0 | -0.3 | 1.8 | -1.9 |
Co content in liver | 0.2 | 0.2 | 0.6 | -0.3 | -0.2 | -0.8 | -0.1 | -0.7 | -0.2 | -0.8 | -0.6 | -0.4 | -0.6 | 0.0 | 0.3 | 0.2 | 0.4 | -0.3 | -0.2 | -0.4 | 0.0 | -0.8 | -0.6 | -0.8 | -0.2 | -0.0 |
Cu content in liver | 0.2 | 0.2 | 1.2 | -0.6 | 0.3 | -0.4 | 0.3 | -0.2 | 0.3 | -1.1 | -0.4 | 0.3 | -0.1 | 0.5 | -0.3 | -0.2 | 0.5 | 0.1 | 0.4 | -0.3 | 0.4 | -0.3 | 0.3 | -0.3 | -0.6 | 0.3 |
Fe content in liver | 0.0 | 0.1 | 0.5 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.7 | 0.3 | -0.1 | 0.4 | 0.2 | -0.0 | -0.2 | -0.1 | 0.2 | 0.1 | 0.4 | 0.2 | 0.3 | -0.2 | 0.3 | 0.0 | 0.1 |
K content in liver | 0.6 | 0.6 | 1.3 | 1.0 | -1.0 | -0.1 | -0.8 | -0.3 | -1.0 | 0.1 | 0.1 | -0.7 | -0.4 | -0.9 | 1.1 | 1.2 | -0.8 | -1.0 | -1.1 | 0.1 | -0.8 | -0.1 | -0.7 | 0.0 | 0.8 | -1.0 |
Mg content in liver | 0.5 | 0.5 | 1.4 | 1.0 | -0.8 | 0.7 | -0.4 | 0.4 | -0.9 | 0.5 | 0.7 | -0.3 | 0.2 | -0.6 | 0.8 | 1.0 | -1.2 | -0.7 | -0.8 | 0.7 | -0.5 | 0.7 | -0.2 | 0.7 | 0.7 | -0.8 |
Mn content in liver | 1.0 | 1.1 | 2.4 | 1.0 | -1.3 | -0.6 | -1.2 | -0.9 | -1.3 | -0.4 | -0.5 | -1.0 | -1.0 | -1.3 | 1.2 | 1.4 | -0.5 | -1.3 | -1.4 | -0.8 | -1.5 | -0.7 | -1.0 | -0.7 | 1.1 | -1.2 |
Na content in liver | 0.7 | 0.7 | 1.8 | 1.3 | -1.1 | 0.7 | -0.5 | 0.2 | -0.9 | 1.1 | 0.8 | -0.6 | 0.3 | -0.8 | 1.0 | 1.0 | -1.4 | -0.5 | -1.1 | 0.7 | -0.9 | 0.6 | -0.5 | 0.7 | 1.2 | -0.8 |
Rb content in liver | 1.6 | 2.1 | 6.3 | 1.4 | -1.7 | 0.6 | -1.6 | -0.2 | -1.7 | 2.5 | 0.4 | -1.6 | -0.4 | -1.7 | 1.6 | 1.4 | -1.7 | -1.4 | -1.7 | 0.3 | -1.7 | 0.2 | -1.5 | 0.3 | 1.9 | -1.7 |
Se content in liver | 0.1 | 0.2 | 0.3 | 0.3 | -0.6 | 0.2 | -0.3 | 0.3 | -0.4 | 0.2 | 0.5 | -0.4 | 0.3 | -0.3 | 0.4 | 0.4 | -0.5 | -0.4 | -0.4 | 0.5 | -0.3 | 0.3 | -0.6 | 0.3 | 0.5 | -0.5 |
Sr content in liver | 2.7 | 2.5 | 4.4 | 0.5 | -1.4 | -1.9 | -1.6 | -2.1 | -1.7 | -0.9 | -1.8 | -1.6 | -2.1 | -1.4 | 1.7 | 1.7 | 0.2 | -1.8 | -1.5 | -1.7 | -1.6 | -1.8 | -1.8 | -1.7 | 0.9 | -1.4 |
Zn content in liver | 2.3 | 2.5 | 4.6 | 0.3 | -1.7 | -1.6 | -1.7 | -1.7 | -1.7 | -1.6 | -1.4 | -1.6 | -1.8 | -1.4 | 1.7 | 1.9 | -0.0 | -2.2 | -1.6 | -1.4 | -1.7 | -1.6 | -1.8 | -1.5 | 1.1 | -1.7 |