Best TWAS P = 8.18e-10 · Best GWAS P= 6.57e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Arrdc4 | gene expression | Arrdc4 | 0.1 | 19 | 0.16 | 5.8e-17 | 5.84 | 5.16e-09 | 0.4 | FALSE |
| Adipose | Fam169b | gene expression | Fam169b | 0.1 | 10 | 0.12 | 5.0e-13 | -5.31 | 1.09e-07 | 0.21 | FALSE |
| Adipose | Arrdc4 | mRNA stability | Arrdc4 | 0.02 | 1 | 0.02 | 1.3e-03 | 5.85 | 4.92e-09 | 0.03 | FALSE |
| Adipose | Igf1r | mRNA stability | Igf1r | 0.07 | 1 | 0.07 | 3.0e-08 | -5.43 | 5.58e-08 | 0.76 | FALSE |
| BLA | Arrdc4 | gene expression | Arrdc4 | 0.05 | 1681 | 0.04 | 4.1e-03 | 6.14 | 8.18e-10 | 0.45 | TRUE |
| BLA | Fam169b | isoform ratio | XR_010063049.1 | 0.22 | 2137 | 0.1 | 8.6e-06 | -5.81 | 6.33e-09 | 0.08 | FALSE |
| IL | Fam169b | gene expression | Fam169b | 0.44 | 1 | 0.29 | 8.7e-08 | -5.28 | 1.32e-07 | 0.05 | FALSE |
| LHb | Fam169b | gene expression | Fam169b | 0.38 | 2137 | 0.26 | 7.6e-07 | -6.02 | 1.76e-09 | 0.04 | FALSE |
| Liver | Arrdc4 | gene expression | Arrdc4 | 0.02 | 3 | 0.02 | 4.4e-03 | -5.8 | 6.64e-09 | 0.34 | TRUE |
| NAcc | Arrdc4 | gene expression | Arrdc4 | 0.04 | 1 | 0.04 | 4.2e-07 | 5.21 | 1.92e-07 | 0.01 | FALSE |
| NAcc | Fam169b | intron excision ratio | chr1_131312478_131313476 | 0.02 | 2137 | 0 | 9.8e-02 | -5.45 | 5.00e-08 | 0.6 | FALSE |