Hub : Traits

Short access day 1 locomotion

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 89760933 91151703 1 1 3.6e-09 0.018 0.00013 -161 Cd59
2 10 46789397 48185455 1 1 3.1e-09 0.025 1.00000 100 Trim16

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 1.8 1 0 0 0 1 Cd59
Heart weight 7.8 1 0 0 0 1 Trim16
Liver weight, left 7.8 1 0 0 0 1 Trim16
Intraocular pressure 38.8 1 1 50 0 1 Trim16
Soleus weight 4.9 1 0 0 0 1 Cd59
Number of licking bursts 19.2 1 0 0 0 1 Trim16
Food consumed during 24 hour testing period 18.6 1 0 0 0 1 Trim16
Times rat made contact with spout 16.5 1 0 0 0 1 Trim16
Mean num. licks in bursts 46.0 1 1 50 0 1 Trim16
Std. dev. time between licks in bursts 5.4 1 0 0 0 1 Trim16
Water consumed over 24 hours 23.8 1 1 50 0 1 Trim16
Indifference point 0 sec 7.9 1 0 0 0 1 Trim16
Delay discounting total patch changes 0 sec 8.5 1 0 0 0 1 Trim16
Delay discounting total patch changes 18 sec 45.7 1 1 50 0 1 Trim16
Delay discounting total patch changes 6 sec 5.0 1 0 0 0 1 Trim16
Delay discounting water rate 0 sec 15.1 1 0 0 0 1 Trim16
Delay discounting water rate 18 sec 4.5 1 0 0 0 1 Cd59
Delay discounting water rate 6 sec 5.5 2 0 0 0 1 Trim16 Cd59
Locomotor activity 4.9 1 0 0 0 1 Trim16
Reaction time number correct 7.5 1 0 0 0 1 Trim16
Reaction time trials correct on left 7.5 1 0 0 0 1 Trim16
Reaction time trials on left 6.9 1 0 0 0 1 Trim16
Reaction time omissions 7.8 1 0 0 0 1 Cd59
Reaction time premature initiation rate 5.8 1 0 0 0 1 Trim16
Reaction time trials completed 6.9 1 0 0 0 1 Trim16
Reaction time trials AUC 6.0 1 0 0 0 1 Trim16
Social response proportion 21.6 1 0 0 0 1 Cd59
Social responses 4.0 1 0 0 0 1 Trim16
Social time 25.9 1 1 50 0 1 Trim16
Cocaine response after cond. corrected 14.6 1 0 0 0 1 Trim16
Cocaine response after cond. not corrected 16.0 1 0 0 0 1 Trim16
Condit. Reinf. lever presses 7.4 1 0 0 0 1 Trim16
Conditioned reinforcement - actives 7.9 1 0 0 0 1 Cd59
Intermitt. access day 1 inactive lever presses 35.0 2 2 100 0 1 Trim16 Cd59
Intermitt. access escalation Index 20.4 2 0 0 0 1 Trim16 Cd59
Intermittent access day 15 total infusions 9.1 1 0 0 0 1 Cd59
Intermittent access terminal intake (last 3 days) 24.4 1 1 50 0 1 Cd59
Intermittent access total infusions 12.0 1 0 0 0 1 Cd59
Intermittent access day 1 locomotion 12.8 1 0 0 0 1 Trim16
Intermittent access day 15 total locomotion 5.9 1 0 0 0 1 Cd59
Intermittent access total locomotion 9.9 1 0 0 0 1 Trim16
Cocaine induced anxiety 31.7 1 1 50 0 1 Trim16
Post-drug Anxiety 10.6 1 0 0 0 1 Trim16
Baseline Anxiety 29.9 1 1 50 0 1 Trim16
Lifetime Intake 11.0 1 0 0 0 1 Cd59
Progressive ratio test 1 active lever presses 4.9 1 0 0 0 1 Cd59
Progressive ratio test 1 breakpoint 7.2 1 0 0 0 1 Cd59
Progressive ratio test 1 inactive lever presses 10.6 1 0 0 0 1 Trim16
Progressive ratio test 2 active lever presses 7.2 1 0 0 0 1 Cd59
Progressive ratio test 2 breakpoint 9.0 1 0 0 0 1 Cd59
Total sessions with >9 infusions 13.7 1 0 0 0 1 Trim16
Short access day 1 total inactive lever presses 13.8 1 0 0 0 1 Trim16
Short access day 10 total inactive lever presses 6.4 1 0 0 0 1 Cd59
Short access day 1 total infusions 37.3 2 1 50 0 1 Trim16 Cd59
Short access day 10 total infusions 5.5 1 0 0 0 1 Cd59
Short access total infusions 7.3 2 0 0 0 1 Trim16 Cd59
Short access day 10 total locomotion 14.3 1 0 0 0 1 Trim16
Short access total locomotion 11.5 2 0 0 0 1 Trim16 Cd59
Compulsive drug intake 11.9 1 0 0 0 1 Trim16
One hour access (shock baseline) 20.4 1 0 0 0 1 Cd59
Number of responses in last shaping day 25.6 1 1 50 0 1 Trim16
Context. condit. distance diff. score 5.0 1 0 0 0 1 Trim16
Locomotion distance, session 1 31.9 1 1 50 0 1 Trim16
Locomotion distance, session 2 15.7 1 0 0 0 1 Trim16
Locomotion velocity, session 7 5.0 1 0 0 0 1 Trim16
Stereotopy head waving bouts, day 7 25.4 1 1 50 0 1 Trim16
Stereotopy head waving duration, day 7 6.5 1 0 0 0 1 Trim16
Degree of sensitization stereotypy 7.4 1 0 0 0 1 Trim16
Condit. Reinf. active minus inactive responses 5.1 1 0 0 0 1 Trim16
Condit. Reinf. active-inactive response ratio 5.1 1 0 0 0 1 Trim16
Incentive salience index mean 5.9 1 0 0 0 1 Trim16
Time in familiar zone, hab. session 1 6.6 1 0 0 0 1 Trim16
Time in novel zone, hab. session 1 5.6 1 0 0 0 1 Trim16
Total zone transitions, hab. session 1 37.4 1 1 50 0 1 Trim16
Total locomotion distance, hab. session 1 38.5 1 1 50 0 1 Trim16
Locomotion velocity, hab. session 1 30.2 1 1 50 0 1 Trim16
Time in familiar zone, hab. session 2 8.6 1 0 0 0 1 Trim16
Total locomotion distance, hab. session 2 11.5 1 0 0 0 1 Trim16
Locomotion velocity, hab. session 2 10.0 1 0 0 0 1 Trim16
Time in novel zone, NPP test 5.2 1 0 0 0 1 Trim16
Total zone transitions, NPP test 3.6 1 0 0 0 1 Trim16
Total locomotion distance, NPP test 4.5 1 0 0 0 1 Trim16
Locomotion velocity, NPP test 4.0 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry latency 30.9 1 1 50 0 1 Trim16
Pavlov. Cond. index score 10.8 1 0 0 0 1 Trim16
Pavlov. Cond. latency score 5.9 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry number 28.0 1 1 50 0 1 Trim16
Pavlov. Cond. intertrial magazine entries 9.6 2 0 0 0 1 Trim16 Cd59
Pavlov. Cond. lever-magazine prob. diff. 10.2 1 0 0 0 1 Trim16
Pavlov. Cond. response bias 8.3 1 0 0 0 1 Trim16
Bone: cortical apparent density 11.1 2 0 0 0 1 Trim16 Cd59
Bone: cortical porosity 21.5 1 0 0 0 1 Trim16
Bone: cortical porosity 27.4 1 1 50 0 1 Trim16
Bone: cortical tissue density 19.6 1 0 0 0 1 Trim16
Bone: elastic work 5.8 1 0 0 0 1 Trim16
Bone: post-yield work 16.2 1 0 0 0 1 Trim16
Bone: tissue strength 7.4 1 0 0 0 1 Trim16
Bone: trabecular tissue density 4.0 1 0 0 0 1 Cd59
Distance traveled before self-admin 5.9 1 0 0 0 1 Cd59
Distance traveled after self-admin 6.2 1 0 0 0 1 Cd59
Delta time in open arm before/after self-admin 7.8 1 0 0 0 1 Cd59
Active lever presses in extinction session 6 6.9 1 0 0 0 1 Cd59
Time to tail flick, vehicle, before self-admin 5.1 1 0 0 0 1 Cd59
Time to tail flick, vehicle, after self-admin 12.1 1 0 0 0 1 Cd59
Time to tail flick, test, before self-admin 7.4 1 0 0 0 1 Cd59
Ambulatory time before self-admin 5.2 1 0 0 0 1 Cd59
Ambulatory time after self-admin 9.1 1 0 0 0 1 Cd59
Total heroin consumption 5.0 1 0 0 0 1 Cd59
Delay disc. indifference point, 16s delay 6.6 1 0 0 0 1 Trim16
Delay discount exponential model param 5.1 1 0 0 0 1 Cd59
Delay discount hyperbolic model param 5.0 1 0 0 0 1 Cd59
Fecal boli incidents, locomotor time 1 8.3 1 0 0 0 1 Cd59
Change in fecal boli incidents, locomotor task 17.1 1 0 0 0 1 Cd59
Bouts of movement, locomotor time 1 7.3 1 0 0 0 1 Cd59
Rest time, locomotor task time 1 6.0 1 0 0 0 1 Cd59
Vertical activity count, locomotor time 1 6.5 1 0 0 0 1 Cd59
Bouts of movement, locomotor time 2 17.4 1 0 0 0 1 Cd59
Total resting periods, locomotor time 2 15.7 1 0 0 0 1 Cd59
Distance moved, locomotor task time 2 6.6 1 0 0 0 1 Trim16
Food seeking constrained by brief footshock 4.2 1 0 0 0 1 Trim16
Run reversals in cocaine runway, females 13.4 2 0 0 0 1 Trim16 Cd59
Run reversals in cocaine runway, males 7.4 2 0 0 0 1 Trim16 Cd59
Latency to leave start box in cocaine runway 10.7 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway, F 7.3 1 0 0 0 1 Trim16
Cu content in liver 6.2 1 0 0 0 1 Trim16
K content in liver 7.8 2 0 0 0 1 Trim16 Cd59
Mg content in liver 17.2 2 1 50 0 1 Trim16 Cd59
Mn content in liver 4.4 1 0 0 0 1 Trim16
Rb content in liver 24.8 1 1 50 0 1 Trim16
Se content in liver 19.8 1 0 0 0 1 Trim16

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 0.99
Adipose alternative TSS 0 0.000 1.12
Adipose gene expression 0 0.000 1.09
Adipose isoform ratio 1 0.035 1.07
Adipose intron excision ratio 0 0.000 1.08
Adipose mRNA stability 0 0.000 1.09
BLA alternative polyA 0 0.000 0.97
BLA alternative TSS 0 0.000 0.94
BLA gene expression 0 0.000 1.10
BLA isoform ratio 0 0.000 0.99
BLA intron excision ratio 0 0.000 1.10
BLA mRNA stability 0 0.000 1.08
Brain alternative polyA 0 0.000 0.94
Brain alternative TSS 0 0.000 1.05
Brain gene expression 0 0.000 1.07
Brain isoform ratio 0 0.000 1.04
Brain intron excision ratio 0 0.000 1.08
Brain mRNA stability 0 0.000 1.05
Eye alternative polyA 0 0.000 0.89
Eye alternative TSS 0 0.000 0.97
Eye gene expression 0 0.000 1.14
Eye isoform ratio 0 0.000 1.07
Eye intron excision ratio 0 0.000 1.07
Eye mRNA stability 0 0.000 1.13
IL alternative polyA 0 0.000 0.82
IL alternative TSS 0 0.000 0.98
IL gene expression 0 0.000 1.02
IL isoform ratio 0 0.000 0.98
IL intron excision ratio 0 0.000 1.06
IL mRNA stability 0 0.000 1.11
LHb alternative polyA 0 0.000 1.00
LHb alternative TSS 0 0.000 1.11
LHb gene expression 0 0.000 1.07
LHb isoform ratio 0 0.000 1.03
LHb intron excision ratio 0 0.000 1.08
LHb mRNA stability 0 0.000 1.12
Liver alternative polyA 0 0.000 0.98
Liver alternative TSS 0 0.000 1.00
Liver gene expression 0 0.000 1.09
Liver isoform ratio 0 0.000 1.03
Liver intron excision ratio 0 0.000 1.05
Liver mRNA stability 0 0.000 1.05
NAcc alternative polyA 0 0.000 0.99
NAcc alternative TSS 0 0.000 1.00
NAcc gene expression 0 0.000 1.09
NAcc isoform ratio 0 0.000 1.05
NAcc intron excision ratio 0 0.000 1.14
NAcc mRNA stability 0 0.000 1.08
OFC alternative polyA 0 0.000 1.00
OFC alternative TSS 0 0.000 1.05
OFC gene expression 0 0.000 1.06
OFC isoform ratio 0 0.000 1.01
OFC intron excision ratio 0 0.000 1.05
OFC mRNA stability 0 0.000 1.10
PL alternative polyA 0 0.000 0.97
PL alternative TSS 0 0.000 1.05
PL gene expression 1 0.014 1.09
PL isoform ratio 0 0.000 1.06
PL intron excision ratio 0 0.000 1.10
PL mRNA stability 0 0.000 1.08

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.