Hub : Genes

Shisa5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000020667	0.06	0.04	7.4e-03	0.01	0.01	0.01	0.01	8.5e-03	1.3e-02	6.7e-02	2.2e-02
2	Eye	gene expression	ENSRNOG00000020667	0.37	0.18	3.7e-04	0.17	0.03	0.08	0.17	1.4e-03	1.1e-01	2.3e-02	1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.9	2.8	3.6	1.9	-1.4
BMI without tail	2.1	4.4	5.1	2.2	-1.9
Body weight	6.4	26.9	29.6	4.9	-5.4
Epididymis fat weight	0.2	0.4	0.8	0.2	-0.9
Glucose	0.3	0.5	0.7	-0.5	-0.8
Heart weight	3.1	4.5	4.7	2.2	-2.1
Left kidney weight	0.8	2.2	3.7	0.9	-1.9
Right kidney weight	0.2	0.7	1.2	-0.4	-1.1
Tail length	5.4	16.4	19.7	3.6	-4.4
Length with tail	7.6	28.0	35.4	4.5	-5.9
Length without tail	5.4	11.9	15.6	2.9	-3.9
Liver weight, left	0.0	0.0	0.0	-0.1	-0.1
Liver weight, right	0.8	1.3	2.4	0.4	-1.6
Parametrial fat weight	0.8	1.6	2.3	0.9	-1.5
Retroperitoneal fat weight	0.5	1.5	2.5	0.7	-1.6
Intraocular pressure	0.5	0.7	1.1	0.6	-1.0
Extensor digitorum longus weight	0.1	0.3	0.6	-0.2	0.8
Soleus weight	3.7	10.8	11.8	3.1	-3.4
Tibialis anterior weight	0.0	0.1	0.1	0.3	-0.2
Tibia length	6.1	17.1	21.7	3.5	-4.7
Number of licking bursts	0.2	0.2	0.3	0.4	0.6
Food consumed during 24 hour testing period	1.6	1.9	2.2	1.2	-1.5
Times rat made contact with spout	0.7	0.8	0.9	0.9	-0.9
Mean time between licks in bursts	1.2	1.7	1.8	-1.3	1.3
Mean num. licks in bursts	0.5	0.6	1.3	-0.0	-1.1
Std. dev. time between licks in bursts	3.5	4.1	6.0	-1.5	2.4
Water consumed over 24 hours	0.1	0.1	0.1	0.4	-0.1
Indifference point 0 sec	0.9	1.4	1.5	1.2	-1.2
Indifference point AUC	0.1	0.2	0.2	-0.5	-0.3
Indifference point function ln k	0.0	0.0	0.1	-0.1	0.3
Indifference point function log k	0.0	0.0	0.1	-0.1	0.3
Delay discounting total patch changes 0 sec	1.2	2.0	2.3	1.5	-1.3
Delay discounting total patch changes 12 sec	0.8	1.1	1.3	0.9	-1.1
Delay discounting total patch changes 18 sec	1.5	1.9	2.3	1.2	-1.5
Delay discounting total patch changes 24 sec	2.4	3.1	3.7	1.5	-1.9
Delay discounting total patch changes 6 sec	0.0	0.1	0.1	-0.0	-0.4
Delay discounting time to switch 0 sec	0.1	0.1	0.2	-0.0	0.5
Delay discounting water rate 0 sec	0.3	0.4	0.6	0.8	-0.5
Delay discounting water rate 12 sec	0.4	0.7	1.0	1.0	-0.5
Delay discounting water rate 18 sec	0.0	0.0	0.0	-0.0	-0.1
Delay discounting water rate 24 sec	0.7	1.0	1.2	0.9	-1.1
Delay discounting water rate 6 sec	0.2	0.3	0.6	0.4	-0.7
Locomotor activity	4.4	7.1	7.6	2.5	-2.8
Locomotor testing distance	3.5	5.8	6.6	2.2	-2.6
Locomotor testing rearing	0.0	0.0	0.0	0.2	0.0
Light reinforcement 1	0.5	0.8	1.0	0.8	-1.0
Light reinforcement 2	0.3	0.4	0.7	-0.8	0.2
Reaction time number correct	1.3	1.9	3.3	-1.8	0.8
Reaction time mean minus median	0.0	0.0	0.1	-0.1	-0.3
Reaction time mean minus median AUC	0.1	0.1	0.2	0.1	-0.4
Reaction time num false alarms	0.4	0.6	0.6	-0.8	0.8
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	0.3
Reaction time trials correct on left	1.3	1.9	3.3	-1.8	0.8
Reaction time trials on left	1.4	1.9	3.2	-1.8	0.8
Reaction time mean	0.0	0.0	0.0	-0.0	-0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.2	0.1
Median of all reaction times	0.0	0.0	0.0	-0.2	0.0
Reaction time omissions	0.2	0.2	0.4	-0.2	0.6
Reaction time false alarm rate	0.0	0.1	0.1	0.3	0.2
Reaction time premature initiation rate	1.9	2.5	2.8	1.5	-1.7
Reaction time premature initiations	0.5	0.8	1.2	0.5	-1.1
Std. dev. reaction times	0.0	0.1	0.1	-0.1	-0.3
Reaction time trials completed	1.4	1.9	3.2	-1.8	0.8
Reaction time trials AUC	1.7	2.4	3.9	-2.0	0.9
Social response proportion	0.4	0.5	0.5	0.7	-0.7
Social responses	0.1	0.2	0.4	0.1	-0.6
Social time	0.3	0.3	0.5	-0.4	0.7
Conditioned locomotion	3.2	3.8	3.9	-2.0	1.9
Cocaine response after cond. corrected	0.3	0.3	0.4	0.6	-0.5
Cocaine response after cond. not corrected	1.4	1.6	2.0	1.1	-1.4
Cocaine response before conditioning	0.9	1.0	1.9	0.5	-1.4
Saline control response	0.8	1.1	1.8	0.7	-1.3
Condit. Reinf. active minus inactive responses	1.8	2.2	2.8	1.3	-1.7
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.9	0.9	-1.4
Condit. Reinf. active responses	1.8	2.5	2.8	1.5	-1.7
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	0.0
Condit. Reinf. lever presses	2.2	3.0	3.8	1.5	-2.0
Condit. Reinf. lever reinforcers received	2.0	2.8	3.1	1.6	-1.8
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.4	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. change in total contacts	2.1	2.9	3.3	1.6	-1.8
Pavlov. Cond. index score	0.1	0.1	0.1	0.2	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	0.2	-0.3
Pavlov. Cond. lever contacts	0.7	0.9	1.5	0.6	-1.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.3	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.2	-0.3
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.1	-0.3
Conditioned reinforcement - actives	0.4	0.4	0.4	-0.7	0.6
Conditioned reinforcement - inactives	0.6	0.7	1.3	-0.3	1.1
Conditioned locomotion	0.6	0.7	1.0	-1.0	0.6
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.1	0.7
Intermittent access intake escalation	0.3	0.3	0.6	-0.2	0.7
Intermittent access intake escalation 2	0.2	0.2	0.3	0.5	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.1
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.0	-0.1	1.0
Intermitt. access escalation Index	0.0	0.0	0.1	-0.3	0.0
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	0.3
Intermittent access day 15 total infusions	0.3	0.3	0.6	-0.3	0.7
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.3	-0.2	0.5
Intermittent access total infusions	0.4	0.5	0.7	-0.5	0.8
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.4	0.5
Intermittent access day 15 total locomotion	1.3	1.4	2.0	-1.4	0.9
Intermittent access total locomotion	1.6	1.8	2.3	-1.5	1.1
Intermittent access standard deviation	0.6	0.7	1.3	1.1	-0.3
Cocaine induced anxiety	0.3	0.3	0.5	0.4	0.7
Post-drug Anxiety	0.1	0.1	0.2	0.2	0.4
Baseline Anxiety	0.7	0.8	1.2	-1.1	0.6
Lifetime Intake	0.4	0.5	0.5	-0.7	0.7
Incentive Sensitization - Responses	1.2	1.2	1.7	-0.8	1.3
Incentive Sensitization - Breakpoint	1.1	1.1	1.7	-0.7	1.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.5	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.6	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.6	-0.2	0.8
Progressive ratio test 2 active lever presses	0.9	0.9	1.2	-0.8	1.1
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	-0.6	0.9
Progressive ratio test 2 inactive lever presses	1.2	1.4	2.7	-0.4	1.6
Total sessions with >9 infusions	0.1	0.1	0.2	0.1	0.4
Short access day 1 total inactive lever presses	4.8	5.4	5.5	-2.3	2.3
Short access day 10 total inactive lever presses	0.5	0.6	1.1	1.1	0.1
Short access day 1 total infusions	1.0	1.1	1.3	-1.0	1.1
Short access day 10 total infusions	0.2	0.2	0.3	-0.5	0.3
Short access total infusions	1.0	1.2	1.6	-1.3	0.9
Short access day 1 locomotion	0.0	0.1	0.1	-0.2	0.2
Short access day 10 total locomotion	0.1	0.1	0.2	-0.5	-0.2
Short access total locomotion	0.1	0.1	0.3	-0.5	0.1
Compulsive drug intake	0.5	0.5	1.0	-1.0	0.1
One hour access (0.3 mA shock)	0.5	0.6	0.8	-0.9	0.5
One hour access (shock baseline)	0.1	0.1	0.2	0.2	0.4
Number of responses in last shaping day	0.6	0.6	1.1	-0.3	1.1
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	0.0
Locomotion velocity, session 1	0.8	0.8	1.6	-1.3	0.2
Locomotion distance, session 1	0.6	0.7	1.5	-0.0	-1.2
Locomotion velocity, session 2	0.3	0.3	0.5	-0.7	0.4
Locomotion distance, session 2	0.2	0.3	0.6	-0.7	-0.0
Locomotion velocity, session 3	0.1	0.2	0.2	-0.5	-0.3
Locomotion distance, session 3	1.2	1.3	1.5	-1.2	1.0
Stereotopy head waving bouts, day 3	0.3	0.4	0.8	0.9	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	0.6	0.8	-0.3
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	-0.2
Locomotion distance, session 7	1.0	1.3	1.4	-1.2	1.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.3	0.1
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.3	-0.7
Locomotion velocity, session 8	0.2	0.2	0.4	-0.2	-0.6
Locomotion distance, session 8	0.3	0.4	0.4	-0.6	-0.7
Degree of sensitization distance	1.0	1.0	1.1	1.0	-1.0
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.4	-0.3
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	-0.4
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.2
Condit. Reinf. inactive responses	0.3	0.3	0.6	-0.1	0.8
Incentive salience index mean	0.0	0.0	0.1	-0.2	0.3
Condit. Reinf. lever presses	1.0	1.4	1.8	-0.9	1.4
Time in familiar zone, hab. session 1	1.3	1.2	2.2	-0.4	1.5
Time in novel zone, hab. session 1	0.7	0.7	1.2	0.4	-1.1
Total zone transitions, hab. session 1	0.4	0.6	1.2	0.1	-1.1
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.3	-0.8
Locomotion velocity, hab. session 1	0.2	0.4	0.6	0.3	-0.8
Time in familiar zone, hab. session 2	0.5	0.5	0.8	-0.4	0.9
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.3	-0.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.3	-0.4
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.5	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.3	-0.7
Novel to familiar place preference ratio	0.4	0.5	0.9	-0.2	-0.9
Novelty place preference	0.5	0.5	0.9	-0.3	-0.9
Time in novel zone, NPP test	0.5	0.5	1.1	-0.0	-1.0
Total zone transitions, NPP test	1.8	2.6	4.6	0.8	-2.1
Total locomotion distance, NPP test	1.1	1.6	2.0	1.0	-1.4
Locomotion velocity, NPP test	1.1	1.6	2.3	0.9	-1.5
Pavlov. Cond. lever latency	3.9	5.0	6.5	1.9	-2.6
Pavlov. Cond. magazine entry latency	4.8	6.2	8.5	-1.9	2.9
Pavlov. Cond. change in total contacts	1.3	1.4	2.3	-0.7	1.5
Pavlov. Cond. index score	4.4	5.6	8.5	-1.7	2.9
Pavlov. Cond. latency score	4.7	6.0	8.4	-1.9	2.9
Pavlov. Cond. lever contacts	1.9	2.2	3.3	-1.1	1.8
Pavlov. Cond. magazine entry number	5.3	6.7	9.8	1.9	-3.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.7	7.5	-1.3	2.7
Pavlov. Cond. response bias	4.7	5.7	8.6	-1.7	2.9
Bone: apparent density	0.2	0.3	0.5	-0.7	-0.2
Bone surface	0.1	0.2	0.3	-0.5	0.2
Bone volume	0.2	0.3	0.7	-0.8	-0.0
Bone: connectivity density	0.5	0.8	1.3	-1.1	0.5
Bone: cortical apparent density	0.3	0.4	0.7	-0.8	0.5
Bone: cortical area	0.1	0.1	0.2	0.0	0.4
Bone: cortical porosity	0.4	0.4	0.8	-0.9	0.2
Bone: cortical porosity	0.7	0.8	1.4	-1.2	0.5
Bone: cortical thickness	0.4	0.6	1.2	1.1	-0.3
Bone: cortical thickness	0.0	0.0	0.0	0.0	0.0
Bone: cortical tissue density	0.4	0.5	0.8	-0.9	0.5
Bone: elastic displacement	0.2	0.2	0.3	0.6	-0.2
Bone: elastic work	0.5	0.7	0.7	0.8	-0.9
Bone: endosteal estimation	0.0	0.0	0.0	-0.2	-0.2
Bone: endosteal perimeter	1.4	2.8	3.3	-1.8	1.5
Bone: final force	1.1	1.8	1.9	1.4	-1.3
Bone: final moment	1.4	2.4	2.5	1.6	-1.5
Bone: marrow area	0.0	0.0	0.1	-0.1	-0.2
Bone: maximum diameter	0.2	0.4	0.6	-0.4	0.8
Bone: maximum force	0.7	1.3	1.3	1.1	-1.2
Bone: maximum moment	0.9	1.6	1.6	1.3	-1.2
Bone: minimum diameter	0.5	0.9	1.1	-1.0	0.8
Bone: periosteal estimation	0.0	0.0	0.0	-0.0	-0.0
Bone: periosteal perimeter	1.2	2.0	2.2	-1.5	1.4
Bone: post-yield work	0.1	0.2	0.3	0.5	-0.2
Bone: stiffness	0.1	0.2	0.2	0.4	-0.5
Bone: tissue strength	3.8	3.6	4.5	2.1	-1.7
Bone: trabecular number	1.4	2.2	3.6	-1.9	0.9
Bone: trabecular spacing	2.6	3.3	5.1	2.3	-1.2
Bone: trabecular thickness	0.3	0.4	0.6	-0.8	-0.4
Bone: trabecular tissue density	0.3	0.4	0.4	0.7	-0.6
Breakpoint value in progressive ratio session	0.2	0.2	0.4	0.6	-0.3
Distance traveled before self-admin	0.4	0.4	0.8	-0.9	0.1
Distance traveled after self-admin	0.9	1.0	1.6	-1.3	0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	-0.5	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.1	-0.3
Diff in mean of infusions in LGA sessions	1.6	1.8	3.6	1.9	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	-0.0
Active lever presses in extinction session 6	0.2	0.1	0.2	-0.4	-0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.1	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.4	-0.3
Time in closed arm before self-admin	1.8	2.1	2.6	1.6	-1.3
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	-0.2
Time in open arm before self-admin	0.8	0.8	0.8	-0.9	0.9
Time in open arm after self-admin	0.6	0.7	1.2	-1.1	0.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.6	0.8	-0.8
Time to tail flick, vehicle, before self-admin	2.2	2.2	2.7	1.6	-1.3
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.1	1.1	-0.8
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.3	-0.5
Time to tail flick, test, after self-admin	0.2	0.3	0.4	0.7	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.4	0.6
Delta time to tail flick, test, before/after SA	0.3	0.2	0.5	0.1	0.7
Ambulatory time before self-admin	0.1	0.1	0.2	-0.1	0.5
Ambulatory time after self-admin	0.9	1.0	1.9	-1.4	0.4
Total heroin consumption	1.4	1.7	2.3	1.5	-1.0
Area under the delay curve	2.3	2.5	2.6	-1.6	1.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	0.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.0	-1.0	1.0
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	-0.9	0.6
Delay disc. indifference point, 24s delay	1.1	1.1	1.3	-1.1	0.9
Delay disc. indifference point, 4s delay	1.9	2.0	2.4	-1.2	1.6
Delay disc. indifference point, 8s delay	2.7	2.8	3.2	-1.8	1.5
Delay discount exponential model param	2.5	2.7	2.8	1.6	-1.7
Delay discount hyperbolic model param	2.5	2.7	2.7	1.6	-1.7
Fecal boli incidents, locomotor time 1	0.9	1.0	1.7	1.3	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.7	-0.8	0.2
Bouts of movement, locomotor time 1	0.4	0.5	1.0	1.0	-0.1
Total resting periods, locomotor time 1	0.3	0.3	0.7	0.8	-0.1
Rest time, locomotor task time 1	0.4	0.4	0.7	-0.3	0.8
Distance moved, locomotor task time 1	1.3	1.4	2.2	0.8	-1.5
Vertical activity count, locomotor time 1	0.8	0.8	1.2	0.6	-1.1
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.7	0.7	-1.3
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.6	0.1
Total resting periods, locomotor time 2	0.4	0.4	0.7	-0.8	0.4
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.1	0.4
Distance moved, locomotor task time 2	0.8	0.9	1.8	0.3	-1.4
Vertical activity count, locomotor time 2	0.2	0.3	0.3	-0.6	-0.5
Weight adjusted by age	0.3	0.3	0.5	0.7	-0.5
Seeking ratio, delayed vs. immediate footshock	2.7	3.0	3.6	-1.6	1.9
Locomotion in novel chamber	0.1	0.1	0.1	-0.4	0.3
Locomotion in novel chamber post-restriction	0.5	0.6	1.2	0.2	-1.1
Progressive ratio	1.9	2.2	4.4	0.3	-2.1
Food seeking constrained by brief footshock	1.4	1.7	2.9	-1.7	0.8
Seeking ratio, punishment vs. effort	3.2	3.9	6.5	-1.2	2.5
Run reversals in cocaine runway, females	1.1	1.1	1.3	-0.9	1.2
Run reversals in cocaine runway, males	1.1	1.1	1.5	1.2	-0.8
Latency to leave start box in cocaine runway	0.4	0.5	0.6	0.6	-0.8
Latency to leave start box in cocaine runway, F	1.9	2.0	2.4	1.6	-1.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.1	-1.0	0.4
Cd content in liver	2.4	2.6	3.4	1.8	-1.4
Co content in liver	0.1	0.1	0.1	0.3	0.2
Cu content in liver	3.8	4.6	4.9	2.2	-2.1
Fe content in liver	2.1	2.4	3.5	1.9	-1.2
K content in liver	1.0	1.0	1.0	1.0	-1.0
Mg content in liver	0.0	0.0	0.1	0.3	-0.1
Mn content in liver	0.4	0.5	0.9	-0.2	-1.0
Na content in liver	0.3	0.3	0.3	0.6	-0.5
Rb content in liver	1.2	1.5	2.6	1.6	-0.6
Se content in liver	0.1	0.1	0.2	0.3	-0.4
Sr content in liver	0.1	0.1	0.1	-0.1	-0.3
Zn content in liver	4.3	4.7	5.3	2.0	-2.3