Hub : Genes

Brca2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000001111 0.26 0.11 2.2e-16 0.09 0.11 0.11 0.11 3.5e-10 1.7e-12 2.0e-12 4.4e-12
2 BLA gene expression ENSRNOG00000001111 0.36 0.14 7.0e-13 0.24 0.22 0.23 0.23 5.4e-13 4.5e-12 1.0e-12 1.1e-12
3 BLA isoform ratio ENSRNOT00000001475 0.09 0.06 4.1e-03 0.01 0.03 0.04 0.03 5.7e-02 7.8e-03 3.6e-03 8.9e-03
4 BLA isoform ratio ENSRNOT00000103794 0.09 0.06 6.0e-03 0.01 0.03 0.03 0.02 8.6e-02 1.3e-02 6.1e-03 2.9e-02
5 BLA mRNA stability ENSRNOG00000001111 0.19 0.1 2.4e-06 0.12 0.1 0.1 0.11 9.3e-07 5.9e-06 3.0e-06 1.2e-06
6 Brain gene expression ENSRNOG00000001111 0.42 0.13 0.0e+00 0.32 0.32 0.32 0.33 1.2e-30 1.1e-29 1.9e-30 6.8e-31
7 Brain mRNA stability ENSRNOG00000001111 0.29 0.15 5.8e-14 0.17 0.16 0.17 0.18 7.1e-16 3.4e-14 5.1e-16 3.2e-16
8 LHb mRNA stability ENSRNOG00000001111 0.19 0.12 6.4e-03 0.12 0.07 0.09 0.08 9.6e-04 9.2e-03 3.4e-03 5.1e-03
9 Liver gene expression ENSRNOG00000001111 0.04 0.03 7.1e-04 0.02 0.02 0.01 0.02 1.7e-03 2.9e-03 9.4e-03 3.8e-03
10 Liver mRNA stability ENSRNOG00000001111 0.15 0.08 2.7e-09 0.07 0.06 0.06 0.06 2.0e-08 8.8e-07 4.9e-07 2.4e-07
11 NAcc gene expression ENSRNOG00000001111 0.27 0.12 1.8e-13 0.18 0.19 0.19 0.19 3.1e-13 5.5e-14 3.6e-14 4.8e-14
12 NAcc mRNA stability ENSRNOG00000001111 0.14 0.08 5.9e-07 0.09 0.08 0.09 0.09 4.6e-07 1.7e-06 5.8e-07 4.2e-07
13 PL gene expression ENSRNOG00000001111 0.44 0.14 0.0e+00 0.26 0.3 0.3 0.31 5.6e-20 1.0e-22 2.3e-23 6.0e-24
14 PL mRNA stability ENSRNOG00000001111 0.19 0.09 3.3e-09 0.12 0.12 0.12 0.13 1.6e-09 1.4e-09 1.9e-09 7.3e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
BMI with tail0.82.77.3-0.11.41.2-1.11.41.31.32.72.61.61.42.70.61.4
BMI without tail1.63.46.40.62.10.7-0.62.11.81.92.22.21.92.02.51.52.2
Body weight10.946.080.33.87.05.0-4.77.06.97.08.37.76.97.09.05.77.1
Epididymis fat weight0.10.31.4-0.40.4-0.40.40.40.30.41.01.20.80.20.50.10.3
Glucose0.71.11.9-1.4-1.1-0.90.9-1.1-1.3-1.2-0.30.0-1.1-1.1-0.7-1.4-1.1
Heart weight0.50.81.50.71.1-0.20.31.11.01.1-0.5-0.51.11.0-0.21.21.1
Left kidney weight11.232.142.04.06.04.1-3.86.06.16.26.15.96.56.16.25.46.0
Right kidney weight7.421.129.33.44.83.3-3.24.84.84.95.04.74.95.05.44.34.9
Tail length5.717.326.82.44.81.9-1.74.84.44.74.44.04.24.65.24.05.0
Length with tail13.850.777.64.57.74.6-4.37.77.57.88.07.57.37.68.86.67.8
Length without tail8.719.032.22.44.43.3-3.24.44.54.65.55.24.34.35.73.54.3
Liver weight, left2.13.46.22.31.32.4-2.41.31.41.22.12.51.91.81.31.81.4
Liver weight, right4.67.69.22.32.72.6-2.52.72.72.62.93.03.03.02.92.72.8
Parametrial fat weight0.20.52.60.4-0.10.8-0.8-0.10.20.21.31.60.50.30.7-0.0-0.0
Retroperitoneal fat weight1.55.09.6-3.1-2.5-2.01.9-2.5-2.6-2.5-0.00.4-2.0-2.5-1.0-3.1-2.5
Intraocular pressure2.33.27.61.41.91.1-1.01.92.02.01.91.92.81.91.41.71.7
Extensor digitorum longus weight4.718.824.42.74.82.9-2.74.84.84.94.54.24.94.64.94.14.8
Soleus weight1.64.76.61.92.52.0-1.92.52.42.41.51.12.02.42.22.52.6
Tibialis anterior weight5.218.028.82.24.82.6-2.44.84.74.84.53.84.64.55.43.94.8
Tibia length3.59.818.31.93.12.9-2.83.13.03.03.93.43.03.14.32.53.2
Number of licking bursts1.41.72.91.71.21.4-1.41.21.31.20.90.91.11.51.01.61.4
Food consumed during 24 hour testing period0.60.81.71.30.71.3-1.30.70.80.70.40.40.70.80.61.00.7
Times rat made contact with spout0.60.71.30.51.10.4-0.41.10.91.00.60.50.81.01.01.01.1
Mean time between licks in bursts1.21.73.0-0.6-1.5-0.60.5-1.5-1.4-1.5-1.5-1.4-1.4-1.3-1.7-1.2-1.5
Mean num. licks in bursts0.10.20.6-0.8-0.3-0.50.5-0.3-0.4-0.3-0.2-0.2-0.2-0.4-0.2-0.5-0.4
Std. dev. time between licks in bursts0.30.30.60.30.60.1-0.00.60.80.80.10.10.70.70.10.70.7
Water consumed over 24 hours4.04.75.82.12.22.1-2.02.22.42.31.81.82.22.32.12.32.3
Indifference point 0 sec0.61.03.61.90.51.7-1.80.50.70.50.40.40.80.80.21.10.5
Indifference point AUC1.01.11.81.21.20.8-0.71.21.31.30.60.61.11.30.81.31.3
Indifference point function ln k0.10.20.50.70.30.2-0.20.30.30.2-0.5-0.40.50.3-0.40.60.3
Indifference point function log k0.10.20.50.70.30.2-0.20.30.30.2-0.5-0.40.50.3-0.40.60.3
Delay discounting total patch changes 0 sec0.71.24.52.10.51.9-2.00.50.70.50.30.30.80.90.11.20.5
Delay discounting total patch changes 12 sec0.60.71.81.30.51.2-1.30.50.80.70.70.70.70.80.60.80.6
Delay discounting total patch changes 18 sec0.91.24.02.00.62.0-2.00.60.80.60.40.30.61.00.31.30.8
Delay discounting total patch changes 24 sec0.81.03.51.90.81.3-1.20.80.90.7-0.3-0.20.81.1-0.31.50.8
Delay discounting total patch changes 6 sec1.11.74.62.21.01.9-1.91.01.21.00.70.71.21.30.71.51.0
Delay discounting time to switch 0 sec2.94.59.3-2.8-2.4-1.41.2-2.4-2.4-2.40.1-0.0-2.4-2.5-0.5-3.1-2.4
Delay discounting water rate 0 sec4.77.513.53.73.02.7-2.63.03.12.90.80.92.73.11.43.62.9
Delay discounting water rate 12 sec0.71.02.31.41.10.6-0.61.11.01.0-0.2-0.11.41.1-0.11.51.1
Delay discounting water rate 18 sec0.20.30.9-0.10.3-0.90.90.30.40.4-0.9-0.80.50.1-0.70.40.2
Delay discounting water rate 24 sec2.63.65.61.92.21.2-1.12.22.42.41.01.02.32.21.32.32.1
Delay discounting water rate 6 sec0.60.92.21.31.20.7-0.61.21.01.0-0.1-0.10.61.10.31.51.2
Locomotor activity2.84.59.01.12.60.3-0.12.62.62.81.31.43.02.41.52.32.6
Locomotor testing distance1.52.53.81.51.71.2-1.11.71.91.90.91.01.91.81.01.91.8
Locomotor testing rearing0.10.20.80.90.10.8-0.80.10.30.2-0.2-0.30.20.3-0.20.50.1
Light reinforcement 11.12.03.9-1.8-1.2-1.92.0-1.2-1.2-1.1-1.4-1.3-1.0-1.3-1.4-1.4-1.1
Light reinforcement 20.10.10.20.1-0.30.1-0.1-0.3-0.2-0.3-0.4-0.4-0.5-0.3-0.4-0.1-0.3
Reaction time number correct0.91.33.01.71.21.0-1.01.21.11.00.40.51.41.30.41.51.1
Reaction time mean minus median1.01.46.7-2.1-0.2-2.52.6-0.2-0.20.1-0.10.10.6-0.5-0.3-0.9-0.2
Reaction time mean minus median AUC0.91.24.6-1.5-0.7-2.12.1-0.7-0.6-0.4-0.8-0.60.4-0.7-1.2-0.9-0.6
Reaction time num false alarms0.60.93.0-1.2-0.3-1.61.7-0.3-0.4-0.3-1.1-1.1-0.4-0.6-0.9-0.6-0.4
Reaction time num false alarms AUC0.30.52.0-0.9-0.2-1.31.4-0.2-0.2-0.1-0.8-0.7-0.1-0.4-0.7-0.4-0.2
Reaction time trials correct on left0.91.33.01.71.21.0-1.01.21.11.00.40.51.41.30.41.51.1
Reaction time trials on left0.81.22.81.71.10.9-0.91.11.01.00.40.51.41.20.41.51.1
Reaction time mean3.95.39.1-3.0-2.3-2.92.9-2.3-2.3-2.1-1.4-1.4-1.6-2.4-2.0-2.7-2.3
Reaction time mean AUC4.15.48.5-2.9-2.3-2.92.9-2.3-2.3-2.2-1.6-1.5-1.6-2.4-2.1-2.6-2.3
Median of all reaction times5.16.99.3-3.0-2.8-2.72.7-2.8-2.8-2.7-1.8-1.8-2.2-2.8-2.4-3.0-2.8
Reaction time omissions1.21.63.1-1.8-1.2-1.41.5-1.2-1.3-1.2-0.9-0.8-0.9-1.2-1.1-1.5-1.2
Reaction time false alarm rate0.71.02.9-1.6-0.6-1.61.7-0.6-0.6-0.4-0.8-0.8-0.7-0.8-0.7-1.0-0.6
Reaction time premature initiation rate0.10.20.9-0.70.2-0.91.00.2-0.00.1-0.0-0.00.2-0.00.0-0.10.2
Reaction time premature initiations0.20.20.70.00.6-0.50.50.60.40.50.20.20.90.50.20.50.6
Std. dev. reaction times1.52.06.4-2.3-1.1-2.52.5-1.1-1.0-0.8-0.5-0.3-0.1-1.2-1.0-1.6-1.1
Reaction time trials completed0.81.22.81.71.10.9-0.91.11.01.00.40.51.41.20.41.51.1
Reaction time trials AUC0.60.82.41.60.90.8-0.80.90.80.80.10.21.21.10.11.30.9
Social response proportion4.04.37.70.22.40.00.12.42.12.42.52.62.82.12.41.62.3
Social responses2.02.65.31.12.00.3-0.22.01.81.91.21.32.31.91.31.92.0
Social time2.53.35.3-1.8-1.6-2.32.3-1.6-1.7-1.6-2.0-1.9-1.3-1.8-2.2-1.6-1.6
Conditioned locomotion0.10.10.40.60.10.5-0.60.10.20.10.40.60.20.30.20.20.1
Cocaine response after cond. corrected0.40.41.4-0.3-0.40.8-0.9-0.4-0.0-0.11.21.0-0.5-0.41.0-0.7-0.4
Cocaine response after cond. not corrected0.30.30.9-0.8-0.4-0.0-0.1-0.4-0.2-0.20.90.7-0.5-0.50.8-0.8-0.4
Cocaine response before conditioning0.30.42.3-0.60.3-1.41.50.3-0.20.0-0.5-0.50.40.1-0.50.10.3
Saline control response3.95.37.92.32.71.3-1.22.72.52.51.62.02.82.71.62.72.6
Condit. Reinf. active minus inactive responses0.81.03.7-0.21.2-0.50.61.20.91.10.90.81.91.10.90.81.2
Condit. Reinf. active-inactive response ratio0.30.31.0-0.60.6-0.81.00.60.20.40.1-0.01.00.40.30.20.6
Condit. Reinf. active responses1.01.44.4-0.21.4-0.60.81.41.11.31.00.82.11.21.00.91.4
Condit. Reinf. inactive responses0.50.61.50.40.9-0.00.00.90.80.90.60.61.20.80.60.91.0
Condit. Reinf. lever presses0.10.21.1-0.10.4-0.40.40.40.30.30.30.51.10.40.20.40.5
Condit. Reinf. lever reinforcers received0.70.93.6-0.41.1-0.91.01.10.81.00.60.51.90.90.60.71.1
Pavlov. Cond. lever latency0.60.83.51.30.41.8-1.90.40.70.50.80.50.00.50.80.60.2
Pavlov. Cond. magazine entry latency2.42.75.7-2.4-1.5-2.32.4-1.5-1.6-1.4-0.8-0.1-1.1-1.7-1.4-1.9-1.5
Pavlov. Cond. change in total contacts0.40.52.3-0.8-0.3-1.51.5-0.3-0.4-0.2-0.7-0.40.5-0.3-0.8-0.3-0.1
Pavlov. Cond. index score1.21.64.9-1.7-0.9-2.22.2-0.9-1.0-0.9-1.1-0.7-0.3-1.1-1.4-1.2-0.9
Pavlov. Cond. latency score1.31.64.5-1.8-1.0-2.12.1-1.0-1.1-0.9-1.0-0.6-0.4-1.1-1.3-1.3-1.0
Pavlov. Cond. lever contacts0.70.93.3-1.4-0.5-1.81.8-0.5-0.8-0.6-0.7-0.5-0.1-0.7-0.8-0.8-0.5
Pavlov. Cond. magazine entry number1.92.34.71.91.42.1-2.21.41.41.31.10.50.91.41.71.61.4
Pavlov. Cond. intertrial magazine entries0.60.81.41.01.10.6-0.61.11.11.10.1-0.50.60.90.71.21.1
Pavlov. Cond. lever-magazine prob. diff.1.41.85.4-1.8-1.0-2.22.3-1.0-1.1-0.9-1.1-0.7-0.4-1.1-1.4-1.2-0.9
Pavlov. Cond. response bias1.31.86.0-1.9-0.8-2.42.4-0.8-1.1-0.9-1.2-0.9-0.5-1.1-1.3-1.1-0.8
Conditioned reinforcement - actives5.85.78.31.82.91.2-1.12.92.82.82.01.92.92.62.22.62.7
Conditioned reinforcement - inactives0.80.91.81.30.91.0-1.00.91.00.90.50.41.01.00.51.10.9
Conditioned locomotion3.44.15.71.52.41.1-1.02.42.32.41.81.72.32.31.92.22.3
Intermittent access intake day 1-15 change2.12.03.71.91.41.5-1.51.41.51.50.70.71.21.61.11.81.5
Intermittent access intake escalation1.91.83.21.71.41.2-1.11.41.61.50.60.51.21.60.91.81.6
Intermittent access intake escalation 20.30.30.91.00.40.5-0.50.40.40.4-0.5-0.50.20.5-0.20.80.5
Intermitt. access day 1 inactive lever presses1.11.22.71.61.01.6-1.61.01.00.90.50.41.11.20.61.30.9
Intermitt. access day 15 inactive lever presses0.40.41.20.1-0.70.9-1.1-0.7-0.6-0.70.70.6-0.5-0.40.4-0.6-0.6
Intermitt. access escalation Index0.60.51.9-0.2-0.3-0.91.0-0.3-0.4-0.3-1.2-1.4-0.3-0.4-1.0-0.1-0.2
Intermittent access day 1 total infusions0.80.92.0-1.1-0.6-1.41.4-0.6-0.8-0.7-1.1-1.2-0.8-0.9-1.0-0.7-0.6
Intermittent access day 15 total infusions0.30.30.80.70.60.0-0.00.60.60.6-0.4-0.40.40.5-0.10.90.7
Intermittent access terminal intake (last 3 days)0.10.10.50.0-0.0-0.30.3-0.0-0.1-0.1-0.7-0.6-0.4-0.2-0.50.1-0.1
Intermittent access total infusions0.50.51.3-0.9-0.4-1.11.1-0.4-0.6-0.5-0.8-0.8-0.7-0.8-0.7-0.5-0.5
Intermittent access day 1 locomotion2.22.23.6-1.7-1.3-1.91.9-1.3-1.4-1.3-1.5-1.5-1.4-1.6-1.4-1.5-1.3
Intermittent access day 15 total locomotion0.20.20.6-0.10.6-0.70.80.60.40.5-0.4-0.40.10.4-0.10.50.6
Intermittent access total locomotion1.11.23.2-1.3-0.6-1.81.8-0.6-0.8-0.7-1.3-1.3-0.9-1.0-1.1-0.9-0.7
Intermittent access standard deviation0.80.93.41.30.41.8-1.80.40.60.50.90.90.20.70.80.70.4
Cocaine induced anxiety0.50.61.2-0.9-0.6-1.11.1-0.6-0.6-0.5-0.7-0.7-0.4-0.8-0.8-0.8-0.7
Post-drug Anxiety5.35.88.0-2.8-2.3-2.82.7-2.3-2.4-2.2-1.9-1.7-2.1-2.7-2.1-2.8-2.5
Baseline Anxiety5.05.37.8-2.5-2.5-2.01.9-2.5-2.6-2.5-1.4-1.3-2.6-2.7-1.6-2.8-2.5
Lifetime Intake0.60.71.0-1.0-0.7-0.90.9-0.7-0.8-0.8-0.7-0.8-0.9-1.0-0.6-0.8-0.7
Incentive Sensitization - Responses0.20.20.60.10.2-0.40.50.20.20.3-0.8-0.70.30.2-0.60.40.3
Incentive Sensitization - Breakpoint0.20.20.70.10.3-0.40.50.30.20.3-0.8-0.80.30.2-0.70.50.3
Progressive ratio test 1 active lever presses0.80.81.10.61.00.5-0.51.01.01.00.91.01.00.90.90.91.0
Progressive ratio test 1 breakpoint0.70.81.00.51.00.4-0.41.01.01.00.91.01.00.90.90.80.9
Progressive ratio test 1 inactive lever presses1.82.03.21.51.60.6-0.61.61.61.70.90.91.71.61.01.81.6
Progressive ratio test 2 active lever presses1.51.52.60.81.60.3-0.21.61.51.60.70.71.51.40.81.51.6
Progressive ratio test 2 breakpoint0.80.91.60.41.2-0.10.21.21.21.30.20.31.21.00.41.21.3
Progressive ratio test 2 inactive lever presses4.45.08.52.72.51.7-1.72.52.52.41.31.22.52.61.52.92.6
Total sessions with >9 infusions0.00.00.1-0.30.1-0.30.30.10.10.10.10.00.0-0.10.1-0.10.0
Short access day 1 total inactive lever presses0.20.30.50.60.40.7-0.70.40.50.40.60.70.40.40.50.50.4
Short access day 10 total inactive lever presses3.03.35.22.11.52.3-2.31.51.61.51.91.81.51.81.91.71.6
Short access day 1 total infusions1.31.42.4-0.6-1.5-0.1-0.1-1.5-1.4-1.5-0.7-0.7-1.4-1.4-0.9-1.4-1.5
Short access day 10 total infusions0.80.81.5-0.7-0.8-0.70.7-0.8-0.8-0.9-1.1-1.2-0.9-1.1-1.1-0.8-1.0
Short access total infusions0.90.91.7-1.1-1.1-0.50.4-1.1-1.1-1.1-0.3-0.3-1.2-1.3-0.4-1.3-1.1
Short access day 1 locomotion1.61.63.4-1.8-1.2-1.51.4-1.2-1.2-1.1-1.0-0.9-1.2-1.4-1.0-1.5-1.2
Short access day 10 total locomotion0.30.30.6-0.3-0.7-0.10.1-0.7-0.6-0.6-0.4-0.5-0.7-0.7-0.5-0.6-0.8
Short access total locomotion1.51.52.5-1.6-1.3-1.11.1-1.3-1.3-1.2-0.7-0.8-1.3-1.5-0.8-1.6-1.4
Compulsive drug intake2.82.84.8-0.8-1.9-0.90.9-1.9-1.8-1.9-1.9-1.7-1.5-1.7-2.2-1.5-1.9
One hour access (0.3 mA shock)0.70.82.11.31.00.4-0.31.01.00.9-0.7-0.71.00.9-0.51.40.9
One hour access (shock baseline)1.82.13.81.11.90.2-0.11.91.71.80.50.41.61.60.91.91.9
Number of responses in last shaping day0.20.20.50.50.40.7-0.70.40.50.50.30.30.50.40.30.50.3
Context. condit. distance diff. score2.32.84.90.52.00.3-0.22.01.92.11.61.22.21.81.91.52.0
Locomotion velocity, session 11.11.22.2-1.1-0.8-1.31.3-0.8-1.2-1.1-1.3-1.5-0.9-0.9-1.1-0.9-0.7
Locomotion distance, session 12.12.74.2-1.1-1.5-1.81.7-1.5-1.8-1.7-2.0-2.1-1.6-1.4-1.9-1.2-1.3
Locomotion velocity, session 20.30.30.9-0.6-0.2-0.91.0-0.2-0.5-0.4-0.7-0.9-0.4-0.4-0.5-0.3-0.2
Locomotion distance, session 21.31.87.3-0.4-0.8-1.31.3-0.8-1.0-0.9-2.4-2.7-1.0-0.9-1.9-0.4-0.7
Locomotion velocity, session 30.00.00.1-0.20.2-0.30.30.2-0.2-0.1-0.0-0.20.10.10.10.00.2
Locomotion distance, session 30.10.10.40.60.20.4-0.40.20.10.1-0.3-0.40.20.2-0.30.30.0
Stereotopy head waving bouts, day 33.13.84.61.82.01.7-1.72.02.12.11.81.32.12.02.12.02.1
Stereotopy head waving duration, day 30.10.10.30.30.20.4-0.40.20.30.30.40.10.60.20.50.20.3
Locomotion velocity, session 71.61.73.9-2.0-1.0-1.91.9-1.0-1.2-1.1-1.0-1.2-1.0-1.2-0.8-1.4-0.9
Locomotion distance, session 70.50.72.1-1.0-0.4-1.41.4-0.4-0.6-0.5-1.1-1.2-0.1-0.5-0.8-0.5-0.3
Stereotopy head waving bouts, day 70.30.30.8-0.4-0.5-0.90.9-0.5-0.2-0.1-0.4-0.10.1-0.5-0.9-0.4-0.6
Stereotopy head waving duration, day 70.30.40.9-0.6-0.7-1.00.9-0.7-0.3-0.3-0.3-0.0-0.2-0.7-0.8-0.7-0.8
Locomotion velocity, session 80.20.20.8-0.70.1-0.90.90.1-0.2-0.1-0.1-0.4-0.4-0.20.2-0.30.1
Locomotion distance, session 80.30.51.10.01.0-0.30.41.00.70.90.3-0.10.70.80.90.71.1
Degree of sensitization distance1.21.22.7-1.4-0.9-1.61.6-0.9-1.0-0.9-1.1-1.0-0.5-1.0-1.1-1.1-0.9
Degree of sensitization stereotypy0.30.30.8-0.7-0.5-0.90.9-0.5-0.3-0.3-0.00.4-0.0-0.6-0.7-0.6-0.7
Condit. Reinf. active minus inactive responses0.70.81.5-1.2-0.6-1.01.0-0.6-0.8-0.8-0.7-0.9-0.8-1.2-0.6-1.2-1.1
Condit. Reinf. active-inactive response ratio0.50.51.6-1.3-0.4-1.01.0-0.4-0.6-0.5-0.1-0.2-0.4-0.9-0.2-1.0-0.8
Condit. Reinf. active responses0.50.62.0-0.8-0.3-1.01.0-0.3-0.2-0.1-1.1-1.4-0.5-0.8-0.7-0.7-0.7
Condit. Reinf. inactive responses0.81.04.6-0.4-0.4-1.01.1-0.4-0.2-0.2-1.9-2.1-0.8-0.7-1.3-0.3-0.5
Incentive salience index mean0.60.71.2-0.9-0.5-1.01.0-0.5-0.7-0.7-1.0-1.1-0.6-1.0-0.9-0.9-0.9
Condit. Reinf. lever presses0.30.51.2-0.5-0.4-0.80.8-0.4-0.6-0.6-1.1-1.0-0.3-0.5-1.0-0.3-0.4
Time in familiar zone, hab. session 10.30.30.90.4-0.70.8-0.9-0.7-0.5-0.60.20.2-0.7-0.3-0.1-0.3-0.6
Time in novel zone, hab. session 10.40.40.7-0.20.8-0.40.40.80.50.60.70.90.90.50.60.30.6
Total zone transitions, hab. session 11.72.44.2-1.4-1.0-1.92.0-1.0-1.3-1.2-2.1-2.0-1.5-1.4-1.8-1.1-1.1
Total locomotion distance, hab. session 10.71.02.4-1.3-0.7-1.51.5-0.7-0.6-0.5-0.9-1.0-0.7-1.1-0.9-1.0-0.9
Locomotion velocity, hab. session 11.72.44.4-1.7-1.2-2.12.1-1.2-1.1-1.0-1.8-1.9-1.2-1.6-1.6-1.4-1.3
Time in familiar zone, hab. session 20.20.20.9-0.3-0.50.2-0.3-0.5-0.4-0.40.0-0.2-0.9-0.50.3-0.5-0.4
Time in novel zone, hab. session 20.20.20.8-0.3-0.0-0.80.9-0.0-0.2-0.2-0.6-0.40.2-0.2-0.8-0.2-0.3
Total zone transitions, hab. session 20.10.10.30.10.5-0.40.50.5-0.00.10.00.20.20.4-0.00.40.5
Total locomotion distance, hab. session 20.10.20.8-0.4-0.1-0.90.9-0.1-0.1-0.0-0.4-0.20.0-0.2-0.6-0.1-0.1
Locomotion velocity, hab. session 20.10.20.7-0.3-0.1-0.80.9-0.1-0.1-0.0-0.4-0.20.1-0.2-0.6-0.1-0.1
Novel to familiar place preference ratio0.10.10.5-0.10.2-0.30.30.20.20.20.30.70.50.1-0.10.10.1
Novelty place preference0.10.10.3-0.3-0.1-0.50.6-0.1-0.2-0.1-0.00.50.2-0.2-0.5-0.1-0.1
Time in novel zone, NPP test0.10.10.2-0.20.1-0.40.40.10.00.10.10.40.4-0.0-0.2-0.00.0
Total zone transitions, NPP test0.10.20.8-0.30.2-0.80.90.2-0.3-0.2-0.5-0.90.2-0.0-0.20.10.2
Total locomotion distance, NPP test0.40.62.5-1.1-0.1-1.61.6-0.1-0.3-0.1-0.6-0.90.1-0.6-0.5-0.6-0.3
Locomotion velocity, NPP test0.40.52.4-0.80.2-1.51.50.20.00.2-0.7-0.90.4-0.3-0.5-0.20.1
Pavlov. Cond. lever latency3.03.74.71.81.91.9-1.81.92.02.02.01.81.82.12.22.02.0
Pavlov. Cond. magazine entry latency0.10.10.3-0.10.3-0.30.30.3-0.1-0.00.20.4-0.10.40.30.30.6
Pavlov. Cond. change in total contacts1.11.23.1-1.8-0.9-1.31.3-0.9-1.1-1.0-0.6-0.6-0.8-1.2-0.6-1.4-1.0
Pavlov. Cond. index score0.30.40.8-0.9-0.5-0.80.9-0.5-0.7-0.7-0.4-0.2-0.6-0.5-0.5-0.7-0.4
Pavlov. Cond. latency score0.71.01.6-1.3-0.8-1.31.3-0.8-1.1-1.0-0.8-0.5-1.0-0.9-0.8-1.0-0.8
Pavlov. Cond. lever contacts2.22.63.2-1.6-1.6-1.51.5-1.6-1.8-1.8-1.6-1.4-1.5-1.7-1.7-1.7-1.7
Pavlov. Cond. magazine entry number0.20.30.60.0-0.70.2-0.3-0.7-0.3-0.4-0.3-0.4-0.6-0.7-0.4-0.6-0.8
Pavlov. Cond. intertrial magazine entries0.81.04.6-0.2-0.8-0.20.2-0.8-0.4-0.4-1.7-2.2-1.0-1.0-1.1-0.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.7-0.8-0.4-0.60.7-0.4-0.7-0.6-0.2-0.0-0.5-0.5-0.3-0.6-0.4
Pavlov. Cond. response bias0.00.10.2-0.40.1-0.40.50.1-0.1-0.00.10.20.10.10.0-0.00.2
Bone: apparent density5.08.313.23.02.63.6-3.62.62.92.72.72.52.33.03.02.92.7
Bone surface4.78.412.52.42.73.1-3.02.72.72.63.43.12.43.03.52.62.9
Bone volume3.15.38.62.21.92.9-2.91.92.12.02.62.41.92.32.72.02.0
Bone: connectivity density6.29.712.13.03.23.4-3.33.23.23.02.82.52.23.53.43.33.4
Bone: cortical apparent density0.81.12.0-1.4-1.1-1.31.3-1.1-1.0-1.0-0.4-0.1-1.0-1.0-0.8-1.3-1.0
Bone: cortical area1.11.73.90.11.40.4-0.31.41.11.21.82.00.91.31.90.91.5
Bone: cortical porosity0.30.30.90.50.60.4-0.40.60.50.50.81.00.70.50.40.50.3
Bone: cortical porosity0.00.00.10.00.2-0.30.20.20.10.10.00.30.30.0-0.30.1-0.1
Bone: cortical thickness0.91.54.10.11.30.5-0.51.31.01.11.82.00.51.31.80.91.4
Bone: cortical thickness1.11.32.10.71.40.4-0.31.41.11.21.11.21.41.41.01.21.4
Bone: cortical tissue density0.91.11.8-1.3-1.2-1.21.2-1.2-1.1-1.0-0.5-0.2-1.0-1.1-0.9-1.3-1.1
Bone: elastic displacement0.50.50.70.90.80.8-0.80.80.60.50.60.60.40.80.70.80.8
Bone: elastic work4.45.76.82.12.62.1-2.02.62.22.22.62.62.32.62.52.42.5
Bone: endosteal estimation1.53.24.72.21.81.9-1.81.81.91.81.20.92.11.91.52.11.9
Bone: endosteal perimeter1.12.24.01.31.70.9-0.81.71.81.81.00.82.01.61.31.71.8
Bone: final force2.43.95.91.02.11.1-1.02.11.81.92.42.42.32.12.31.82.2
Bone: final moment2.03.35.91.01.91.2-1.11.91.61.72.32.42.02.02.11.62.0
Bone: marrow area1.53.35.02.21.81.9-1.91.81.91.81.10.82.11.91.52.21.9
Bone: maximum diameter1.52.74.11.21.71.4-1.41.71.71.71.81.71.61.72.01.51.8
Bone: maximum force2.34.05.21.42.21.5-1.42.22.02.02.12.02.32.22.22.02.3
Bone: maximum moment2.03.54.31.42.01.6-1.52.01.81.82.02.02.02.12.01.92.0
Bone: minimum diameter0.00.00.20.30.10.2-0.20.10.20.20.20.4-0.10.20.00.20.2
Bone: periosteal estimation1.73.54.81.52.01.4-1.32.01.91.91.81.71.92.12.12.02.2
Bone: periosteal perimeter0.50.91.50.31.1-0.10.21.11.01.10.91.11.11.10.90.91.2
Bone: post-yield work0.30.40.90.70.60.9-0.90.60.70.70.40.50.60.70.50.70.6
Bone: stiffness0.50.91.60.21.20.10.11.21.11.20.60.41.11.10.81.01.3
Bone: tissue strength0.60.52.51.20.01.5-1.60.00.30.10.50.80.10.40.20.4-0.0
Bone: trabecular number4.46.88.62.32.52.9-2.82.52.62.52.62.32.22.82.92.52.6
Bone: trabecular spacing3.24.15.6-1.5-2.3-1.71.6-2.3-2.2-2.2-1.9-1.3-2.1-2.2-2.4-2.1-2.3
Bone: trabecular thickness4.65.67.51.92.42.3-2.22.42.62.52.52.22.42.52.72.22.4
Bone: trabecular tissue density1.21.66.8-2.4-0.3-2.52.6-0.3-0.5-0.20.40.70.8-0.6-0.2-1.1-0.3
Breakpoint value in progressive ratio session0.20.21.2-1.10.1-1.01.10.1-0.10.10.00.0-0.0-0.10.2-0.30.1
Distance traveled before self-admin0.60.62.0-1.2-0.4-1.41.4-0.4-0.5-0.4-0.5-0.7-0.5-0.7-0.5-0.7-0.4
Distance traveled after self-admin0.10.10.5-0.20.3-0.70.70.30.10.2-0.4-0.40.10.0-0.20.20.2
Delta time in closed arm before/after self-admin0.10.10.1-0.30.3-0.20.30.30.10.2-0.3-0.2-0.00.20.20.20.4
Delta time in open arm before/after self-admin3.23.14.0-1.2-1.9-1.41.3-1.9-1.8-1.8-1.8-1.9-1.9-1.9-2.0-1.6-1.9
Diff in mean of infusions in LGA sessions0.10.10.20.10.2-0.40.40.20.20.2-0.4-0.30.40.2-0.30.30.2
Extinction: sum of active levers before priming1.41.42.0-1.2-1.1-1.31.3-1.1-1.2-1.1-1.4-1.3-1.0-1.2-1.4-1.1-1.1
Active lever presses in extinction session 60.00.00.10.20.20.3-0.20.20.10.1-0.3-0.1-0.20.30.10.30.3
Delta distance traveled before/after self-admin0.30.31.01.00.50.5-0.50.50.50.4-0.1-0.00.50.6-0.10.80.5
Delta ambulatory time before/after self-admin0.10.10.40.5-0.10.1-0.1-0.1-0.1-0.1-0.5-0.5-0.1-0.1-0.60.1-0.2
Time in closed arm before self-admin2.83.25.12.01.81.3-1.31.82.12.11.51.62.31.91.32.01.8
Time in closed arm after self-admin1.92.03.81.41.70.7-0.61.71.71.80.60.71.91.70.81.81.7
Time in open arm before self-admin0.10.10.1-0.40.4-0.30.30.4-0.1-0.00.1-0.0-0.00.10.30.10.3
Time in open arm after self-admin0.40.40.7-0.6-0.7-0.50.4-0.7-0.8-0.8-0.3-0.4-0.9-0.8-0.4-0.8-0.8
Sum of active levers in priming session hrs 5-61.21.22.0-1.4-1.2-0.90.9-1.2-1.2-1.2-0.5-0.3-1.3-1.2-0.4-1.4-1.1
Time to tail flick, vehicle, before self-admin1.91.95.2-2.1-1.0-2.32.2-1.0-1.2-1.0-0.7-0.6-1.0-1.4-0.6-1.5-1.0
Time to tail flick, vehicle, after self-admin0.40.40.8-0.8-0.5-0.80.9-0.5-0.5-0.4-0.9-0.7-0.3-0.5-0.8-0.5-0.4
Time to tail flick, test, before self-admin0.60.60.80.70.80.5-0.50.80.80.80.90.80.80.80.80.70.8
Time to tail flick, test, after self-admin0.20.20.5-0.7-0.3-0.00.0-0.3-0.3-0.30.50.5-0.4-0.30.4-0.7-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.70.5-0.30.4-0.3-0.3-0.2-0.3-0.8-0.8-0.2-0.0-0.90.1-0.3
Delta time to tail flick, test, before/after SA0.40.30.6-0.6-0.80.1-0.1-0.8-0.6-0.7-0.2-0.2-0.7-0.6-0.3-0.8-0.7
Ambulatory time before self-admin0.40.52.3-1.1-0.1-1.41.5-0.1-0.2-0.0-0.4-0.4-0.0-0.4-0.4-0.4-0.1
Ambulatory time after self-admin0.20.20.9-0.50.0-0.91.00.0-0.1-0.0-0.5-0.6-0.1-0.3-0.5-0.1-0.1
Total heroin consumption5.06.07.9-2.4-2.3-2.82.8-2.3-2.4-2.2-2.7-2.8-2.2-2.4-2.7-2.2-2.2
Area under the delay curve1.81.96.3-2.3-0.8-2.52.5-0.8-0.9-0.6-0.5-0.5-0.6-1.4-0.7-1.6-1.0
Delay disc. indifference point, 0s delay1.01.14.8-2.2-0.5-1.41.3-0.5-0.7-0.51.11.1-0.5-0.90.7-1.4-0.5
Delay disc. indifference point, 16s delay0.60.72.6-1.2-0.3-1.61.6-0.3-0.3-0.1-0.4-0.3-0.0-0.7-0.6-0.8-0.6
Delay disc. indifference point, 2s delay3.64.010.1-3.2-1.7-2.82.8-1.7-1.8-1.6-0.8-0.8-1.5-2.2-1.2-2.5-1.8
Delay disc. indifference point, 24s delay0.70.72.0-1.2-0.5-1.41.4-0.5-0.5-0.4-0.6-0.6-0.5-1.0-0.7-0.9-0.7
Delay disc. indifference point, 4s delay1.71.84.8-2.2-1.1-2.02.0-1.1-1.2-1.0-0.4-0.4-1.0-1.5-0.7-1.7-1.2
Delay disc. indifference point, 8s delay0.90.93.7-1.2-0.4-1.91.9-0.4-0.5-0.3-0.7-0.6-0.2-0.8-0.7-0.8-0.6
Delay discount exponential model param2.12.27.12.40.92.7-2.70.90.90.70.80.70.61.40.91.61.1
Delay discount hyperbolic model param2.12.36.72.41.02.6-2.61.01.00.80.70.70.71.50.91.71.2
Fecal boli incidents, locomotor time 11.11.21.90.81.30.5-0.41.31.31.30.80.81.31.31.11.31.4
Change in fecal boli incidents, locomotor task0.50.40.9-0.4-0.80.0-0.1-0.8-0.9-1.0-0.2-0.2-0.9-0.8-0.5-0.7-0.7
Time >=10cm from walls, locomotor time 13.23.24.5-2.1-1.8-1.91.8-1.8-2.0-1.9-1.2-1.2-1.8-2.0-1.5-2.0-1.8
Bouts of movement, locomotor time 11.92.13.21.11.80.6-0.61.81.71.81.41.41.61.51.51.51.5
Total resting periods, locomotor time 11.61.83.00.91.70.4-0.41.71.61.71.31.31.51.31.41.31.4
Rest time, locomotor task time 10.60.61.00.40.90.6-0.60.90.80.81.01.00.70.81.00.70.9
Distance moved, locomotor task time 10.40.51.0-0.5-0.6-0.91.0-0.6-0.5-0.5-1.0-0.9-0.4-0.5-0.8-0.5-0.6
Vertical activity count, locomotor time 10.20.20.60.30.5-0.80.80.50.40.5-0.4-0.40.50.4-0.10.50.5
Time >=10cm from walls, locomotor time 20.30.31.1-1.0-0.0-0.40.4-0.0-0.2-0.11.00.9-0.1-0.10.7-0.50.0
Bouts of movement, locomotor time 22.22.43.51.11.90.7-0.71.91.81.91.41.51.71.51.61.61.6
Total resting periods, locomotor time 22.12.33.21.21.80.7-0.71.81.71.81.51.51.61.41.71.51.5
Rest time, locomotor task time 20.10.20.3-0.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.4-0.6-0.5-0.4-0.3-0.3
Distance moved, locomotor task time 20.10.20.40.60.40.5-0.50.40.40.40.10.10.40.50.20.50.4
Vertical activity count, locomotor time 22.72.94.11.81.91.4-1.31.91.81.81.21.21.82.01.52.01.9
Weight adjusted by age1.31.42.31.51.21.4-1.41.21.21.11.00.91.21.10.91.41.1
Seeking ratio, delayed vs. immediate footshock1.72.03.2-0.1-1.60.5-0.5-1.6-1.6-1.8-1.6-1.6-1.7-1.3-1.7-1.1-1.5
Locomotion in novel chamber0.60.81.20.90.90.6-0.60.91.01.00.50.60.91.10.71.11.0
Locomotion in novel chamber post-restriction2.93.55.41.42.30.8-0.72.32.22.31.11.22.22.21.62.22.3
Progressive ratio0.60.71.4-0.4-1.1-0.30.2-1.1-1.1-1.1-0.5-0.6-1.2-0.9-0.7-0.8-0.9
Food seeking constrained by brief footshock0.80.91.30.8-1.11.0-1.1-1.1-0.8-1.1-1.0-1.0-0.9-0.6-1.2-0.4-1.1
Seeking ratio, punishment vs. effort0.70.81.31.10.91.2-1.10.91.00.90.50.61.11.00.61.00.7
Run reversals in cocaine runway, females0.20.20.5-0.2-0.6-0.20.2-0.6-0.4-0.4-0.5-0.4-0.4-0.6-0.7-0.5-0.7
Run reversals in cocaine runway, males0.30.31.01.00.30.3-0.30.30.30.3-0.9-0.90.20.4-0.40.90.5
Latency to leave start box in cocaine runway0.30.30.7-0.8-0.5-0.60.6-0.5-0.6-0.5-0.2-0.2-0.5-0.5-0.3-0.7-0.5
Latency to leave start box in cocaine runway, F0.20.20.9-0.10.00.4-0.40.00.00.00.91.00.10.10.7-0.20.1
Latency to leave start box in cocaine runway, M1.11.03.1-0.7-0.6-1.01.2-0.6-0.7-0.6-1.8-1.7-0.8-0.6-1.4-0.5-0.6
Cd content in liver1.61.76.70.3-0.9-0.50.5-0.9-0.9-1.0-2.5-2.6-1.1-0.8-2.1-0.2-0.9
Co content in liver1.01.23.71.90.91.6-1.70.90.90.7-0.1-0.50.41.10.51.41.0
Cu content in liver0.10.20.50.7-0.10.5-0.6-0.1-0.1-0.2-0.5-0.7-0.20.2-0.50.3-0.2
Fe content in liver1.82.23.40.91.80.6-0.51.81.81.81.21.21.51.71.31.71.8
K content in liver0.10.11.1-0.10.0-0.0-0.00.00.10.10.71.0-0.10.20.2-0.0-0.0
Mg content in liver0.40.41.30.40.60.5-0.50.60.50.50.91.10.30.80.70.50.6
Mn content in liver0.30.40.9-0.1-0.80.1-0.2-0.8-0.8-0.9-0.20.2-0.8-0.6-0.7-0.6-0.8
Na content in liver0.20.21.2-0.40.2-0.30.40.2-0.00.10.81.1-0.10.20.4-0.20.1
Rb content in liver2.12.63.4-1.0-1.8-1.21.1-1.8-1.8-1.8-1.6-1.6-1.7-1.6-1.9-1.5-1.8
Se content in liver0.20.31.2-1.10.3-0.70.70.30.00.20.40.3-0.7-0.00.8-0.30.3
Sr content in liver0.80.82.31.50.51.4-1.50.50.70.50.70.50.30.80.60.90.5
Zn content in liver4.24.76.12.42.02.3-2.32.02.12.02.32.51.92.32.22.12.0