All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.
# | Tissue | Modality | RNA phenotype | h2 | h2 SE | h2 P | xQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | xQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000065260 | 0.17 | 0.07 | 2.6e-15 | 0.12 | 0.1 | 0.11 | 0.11 | 3.2e-13 | 1.0e-11 | 7.1e-12 | 2.2e-12 |
2 | BLA | gene expression | ENSRNOG00000065260 | 0.36 | 0.13 | 3.6e-13 | 0.23 | 0.22 | 0.22 | 0.21 | 1.9e-12 | 5.1e-12 | 9.2e-12 | 1.5e-11 |
3 | Brain | gene expression | ENSRNOG00000065260 | 0.37 | 0.1 | 0.0e+00 | 0.39 | 0.38 | 0.36 | 0.37 | 3.9e-38 | 1.5e-36 | 3.0e-34 | 2.0e-36 |
4 | Eye | gene expression | ENSRNOG00000065260 | 0.45 | 0.17 | 1.6e-03 | 0.18 | 0.12 | 0.14 | 0.15 | 9.5e-04 | 7.0e-03 | 4.2e-03 | 2.5e-03 |
5 | IL | gene expression | ENSRNOG00000065260 | 0.38 | 0.14 | 4.9e-06 | 0.26 | 0.25 | 0.24 | 0.26 | 4.6e-07 | 1.1e-06 | 2.0e-06 | 7.4e-07 |
6 | LHb | gene expression | ENSRNOG00000065260 | 0.45 | 0.15 | 2.3e-06 | 0.19 | 0.25 | 0.25 | 0.23 | 2.6e-05 | 1.4e-06 | 1.3e-06 | 4.1e-06 |
7 | Liver | gene expression | ENSRNOG00000065260 | 0.29 | 0.1 | 0.0e+00 | 0.23 | 0.21 | 0.23 | 0.23 | 1.9e-25 | 3.2e-23 | 2.3e-25 | 1.1e-25 |
8 | NAcc | gene expression | ENSRNOG00000065260 | 0.36 | 0.11 | 0.0e+00 | 0.29 | 0.3 | 0.3 | 0.3 | 8.3e-22 | 1.0e-22 | 1.2e-22 | 5.7e-23 |
9 | OFC | gene expression | ENSRNOG00000065260 | 0.33 | 0.15 | 8.6e-05 | 0.13 | 0.17 | 0.21 | 0.15 | 4.8e-04 | 6.4e-05 | 1.0e-05 | 2.3e-04 |
10 | PL | gene expression | ENSRNOG00000065260 | 0.46 | 0.14 | 0.0e+00 | 0.28 | 0.28 | 0.28 | 0.28 | 1.7e-21 | 1.6e-21 | 1.2e-21 | 1.5e-21 |
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BMI with tail | 10.3 | 33.3 | 129.5 | -4.9 | -5.4 | -5.5 | -11.4 | -5.6 | 1.7 | -4.8 | -5.0 | -4.4 | -4.3 |
BMI without tail | 8.0 | 16.7 | 58.1 | -3.5 | -4.1 | -4.1 | -7.6 | -4.1 | 1.0 | -3.4 | -3.6 | -3.2 | -3.2 |
Body weight | 10.5 | 44.4 | 155.3 | -6.0 | -6.4 | -6.5 | -12.5 | -6.6 | 1.6 | -5.7 | -6.1 | -5.4 | -5.0 |
Epididymis fat weight | 16.7 | 39.0 | 106.3 | -6.1 | -6.1 | -6.2 | -10.3 | -6.3 | 0.5 | -6.0 | -6.1 | -6.0 | -4.7 |
Glucose | 2.0 | 3.0 | 8.7 | -1.2 | -1.7 | -1.8 | -2.9 | -1.8 | 1.3 | -1.1 | -1.3 | -2.2 | -1.1 |
Heart weight | 2.2 | 3.1 | 14.9 | -0.9 | -1.7 | -1.8 | -3.9 | -1.8 | 1.2 | -0.9 | -1.1 | -1.0 | -1.3 |
Left kidney weight | 2.9 | 8.2 | 44.7 | -2.3 | -2.3 | -2.6 | -6.7 | -2.7 | 0.5 | -2.2 | -2.2 | -0.3 | -1.7 |
Right kidney weight | 2.7 | 7.6 | 42.0 | -2.5 | -1.9 | -2.2 | -6.5 | -2.3 | 0.7 | -2.3 | -2.3 | -0.5 | -1.6 |
Tail length | 0.5 | 1.6 | 4.3 | -1.2 | -1.4 | -1.4 | -2.1 | -1.3 | 0.1 | -1.2 | -1.3 | -1.0 | -1.0 |
Length with tail | 1.4 | 5.3 | 15.7 | -2.1 | -2.3 | -2.3 | -4.0 | -2.4 | 0.4 | -2.0 | -2.2 | -2.0 | -1.9 |
Length without tail | 2.1 | 4.7 | 13.5 | -1.9 | -2.1 | -2.2 | -3.7 | -2.2 | 0.3 | -1.8 | -2.0 | -1.9 | -2.0 |
Liver weight, left | 3.1 | 4.9 | 12.2 | -2.2 | -2.1 | -2.0 | -3.5 | -2.0 | 0.6 | -2.2 | -2.1 | -2.7 | -1.7 |
Liver weight, right | 6.3 | 10.5 | 24.1 | -3.2 | -3.3 | -3.2 | -4.9 | -3.3 | -0.1 | -3.1 | -3.2 | -3.2 | -2.8 |
Parametrial fat weight | 11.8 | 23.0 | 63.9 | -5.0 | -4.3 | -4.5 | -8.0 | -4.5 | 0.3 | -5.0 | -4.9 | -4.7 | -3.4 |
Retroperitoneal fat weight | 16.2 | 53.6 | 177.2 | -6.7 | -6.9 | -7.2 | -13.3 | -7.3 | 1.3 | -6.6 | -6.8 | -6.6 | -5.2 |
Intraocular pressure | 1.5 | 2.1 | 5.3 | -1.6 | -1.3 | -1.3 | 0.0 | -1.3 | -0.7 | -1.5 | -1.5 | -2.3 | -1.7 |
Extensor digitorum longus weight | 1.0 | 4.1 | 13.2 | -1.9 | -2.0 | -2.0 | -3.6 | -1.9 | 0.1 | -1.9 | -2.1 | -1.3 | -1.7 |
Soleus weight | 0.5 | 1.4 | 9.1 | -0.0 | 0.2 | 0.1 | -3.0 | 0.1 | 2.1 | 0.1 | -0.0 | 0.2 | 0.5 |
Tibialis anterior weight | 0.3 | 0.9 | 2.2 | -0.9 | -1.0 | -0.9 | -1.5 | -1.0 | 0.2 | -0.8 | -1.0 | -0.8 | -0.9 |
Tibia length | 0.1 | 0.4 | 1.3 | -0.4 | -0.7 | -0.7 | -1.1 | -0.7 | 0.3 | -0.3 | -0.4 | -0.5 | -0.9 |
Number of licking bursts | 0.9 | 1.0 | 1.8 | -1.1 | -1.0 | -1.0 | -0.3 | -1.0 | -0.6 | -1.1 | -1.1 | -1.3 | -1.2 |
Food consumed during 24 hour testing period | 0.4 | 0.5 | 1.6 | -0.6 | -0.8 | -0.7 | -1.2 | -0.7 | -0.4 | -0.6 | -0.6 | 0.0 | -0.9 |
Times rat made contact with spout | 1.0 | 1.1 | 3.4 | -0.8 | -1.1 | -1.1 | -1.9 | -1.1 | -0.2 | -0.8 | -0.9 | -0.4 | -1.3 |
Mean time between licks in bursts | 2.8 | 3.9 | 5.7 | -2.2 | -1.9 | -1.9 | -0.3 | -1.9 | -2.2 | -2.2 | -2.1 | -1.8 | -2.4 |
Mean num. licks in bursts | 0.5 | 0.6 | 1.9 | 0.8 | 0.5 | 0.5 | -0.8 | 0.5 | 0.5 | 0.8 | 0.7 | 1.4 | 0.6 |
Std. dev. time between licks in bursts | 0.9 | 1.1 | 3.2 | -1.0 | -0.9 | -0.9 | 0.7 | -0.9 | -1.8 | -0.9 | -0.9 | -0.6 | -1.4 |
Water consumed over 24 hours | 0.1 | 0.2 | 0.8 | 0.3 | 0.2 | 0.1 | -0.6 | 0.2 | 0.1 | 0.3 | 0.3 | 0.9 | -0.2 |
Indifference point 0 sec | 1.4 | 2.2 | 10.1 | -1.4 | -0.9 | -1.1 | -3.2 | -0.9 | 1.3 | -1.3 | -1.3 | -1.6 | -0.4 |
Indifference point AUC | 0.4 | 0.5 | 1.2 | -0.3 | 0.9 | 0.9 | 0.1 | 0.9 | 1.0 | -0.2 | 0.1 | -0.7 | 1.1 |
Indifference point function ln k | 0.2 | 0.3 | 1.1 | 0.1 | -0.6 | -0.5 | -1.1 | -0.5 | -0.3 | 0.0 | -0.1 | 0.7 | 0.0 |
Indifference point function log k | 0.2 | 0.3 | 1.1 | 0.1 | -0.6 | -0.5 | -1.1 | -0.5 | -0.3 | 0.0 | -0.1 | 0.7 | 0.0 |
Delay discounting total patch changes 0 sec | 1.6 | 2.6 | 12.2 | -1.5 | -1.0 | -1.2 | -3.5 | -1.0 | 1.4 | -1.4 | -1.4 | -1.7 | -0.3 |
Delay discounting total patch changes 12 sec | 1.4 | 1.9 | 5.1 | -1.7 | -0.8 | -0.9 | -2.3 | -0.8 | 0.8 | -1.6 | -1.4 | -1.8 | -0.7 |
Delay discounting total patch changes 18 sec | 1.2 | 1.6 | 3.4 | -1.6 | -0.7 | -0.8 | -1.8 | -0.8 | 0.5 | -1.5 | -1.3 | -1.7 | -0.7 |
Delay discounting total patch changes 24 sec | 0.6 | 0.7 | 2.6 | -1.2 | 0.3 | 0.1 | -0.4 | 0.2 | 0.7 | -1.2 | -0.8 | -1.6 | 0.6 |
Delay discounting total patch changes 6 sec | 1.6 | 2.4 | 6.6 | -2.0 | -0.4 | -0.6 | -2.6 | -0.4 | 1.1 | -2.0 | -1.6 | -2.2 | -0.0 |
Delay discounting time to switch 0 sec | 0.2 | 0.3 | 1.6 | 0.3 | -0.0 | 0.1 | 1.3 | 0.1 | -0.8 | 0.3 | 0.2 | 0.5 | -0.9 |
Delay discounting water rate 0 sec | 0.4 | 0.7 | 4.0 | -0.5 | -0.1 | -0.2 | -2.0 | -0.2 | 1.3 | -0.4 | -0.3 | -0.6 | 0.6 |
Delay discounting water rate 12 sec | 0.8 | 1.2 | 4.5 | -0.8 | -0.9 | -1.1 | -2.1 | -1.1 | 0.8 | -0.8 | -0.8 | -1.2 | -0.4 |
Delay discounting water rate 18 sec | 0.5 | 0.7 | 1.6 | 0.5 | 0.7 | 0.5 | -1.2 | 0.4 | 1.3 | 0.5 | 0.6 | 0.8 | 1.2 |
Delay discounting water rate 24 sec | 0.9 | 1.2 | 6.2 | 0.3 | 0.5 | 0.3 | -2.5 | 0.2 | 1.9 | 0.3 | 0.4 | 0.5 | 1.1 |
Delay discounting water rate 6 sec | 0.4 | 0.5 | 3.8 | -0.2 | -0.1 | -0.1 | -1.9 | -0.1 | 1.0 | -0.2 | -0.1 | 0.2 | 0.6 |
Locomotor activity | 0.0 | 0.1 | 0.1 | -0.1 | -0.3 | -0.4 | 0.1 | -0.3 | -0.2 | -0.1 | -0.2 | -0.2 | -0.3 |
Locomotor testing distance | 0.2 | 0.4 | 1.0 | 0.6 | 0.5 | 0.5 | 0.8 | 0.6 | -0.2 | 0.6 | 0.5 | 1.0 | 0.4 |
Locomotor testing rearing | 0.8 | 1.3 | 2.2 | 1.2 | 1.1 | 1.1 | 0.2 | 1.1 | 0.9 | 1.2 | 1.1 | 1.4 | 1.5 |
Light reinforcement 1 | 0.2 | 0.4 | 1.0 | 0.3 | 0.7 | 0.6 | 0.1 | 0.8 | -0.0 | 0.2 | 0.4 | 1.0 | 0.9 |
Light reinforcement 2 | 0.1 | 0.2 | 0.6 | 0.2 | -0.4 | -0.4 | 0.6 | -0.5 | -0.8 | 0.2 | 0.0 | 0.4 | -0.4 |
Reaction time number correct | 0.2 | 0.3 | 0.6 | -0.2 | -0.6 | -0.6 | -0.7 | -0.6 | 0.4 | -0.1 | -0.3 | -0.7 | -0.8 |
Reaction time mean minus median | 1.2 | 1.6 | 2.8 | 1.3 | 1.1 | 1.3 | 0.6 | 1.2 | 1.6 | 1.3 | 1.2 | 0.5 | 1.7 |
Reaction time mean minus median AUC | 3.5 | 4.5 | 6.4 | 2.5 | 2.0 | 2.2 | 0.9 | 2.1 | 2.5 | 2.5 | 2.3 | 1.5 | 2.3 |
Reaction time num false alarms | 0.5 | 0.7 | 2.2 | -0.5 | -0.9 | -1.0 | -1.5 | -0.9 | -0.5 | -0.5 | -0.5 | 0.3 | -1.2 |
Reaction time num false alarms AUC | 0.4 | 0.6 | 2.5 | -0.2 | -0.8 | -0.9 | -1.6 | -0.7 | -0.0 | -0.1 | -0.2 | 0.4 | -1.0 |
Reaction time trials correct on left | 0.2 | 0.3 | 0.6 | -0.2 | -0.6 | -0.6 | -0.7 | -0.6 | 0.4 | -0.1 | -0.3 | -0.7 | -0.8 |
Reaction time trials on left | 0.2 | 0.3 | 0.7 | -0.3 | -0.6 | -0.6 | -0.7 | -0.6 | 0.4 | -0.1 | -0.4 | -0.8 | -0.8 |
Reaction time mean | 2.9 | 4.0 | 6.6 | 2.0 | 2.0 | 2.2 | 2.6 | 2.1 | 1.6 | 2.1 | 2.1 | 0.9 | 2.0 |
Reaction time mean AUC | 3.9 | 5.2 | 7.2 | 2.3 | 2.3 | 2.5 | 2.7 | 2.4 | 1.8 | 2.4 | 2.3 | 1.2 | 2.3 |
Median of all reaction times | 3.4 | 4.5 | 7.7 | 2.2 | 2.2 | 2.4 | 2.8 | 2.3 | 1.5 | 2.2 | 2.2 | 1.1 | 2.0 |
Reaction time omissions | 0.1 | 0.2 | 0.8 | -0.4 | 0.0 | 0.1 | 0.9 | 0.0 | -0.3 | -0.4 | -0.2 | -0.8 | -0.2 |
Reaction time false alarm rate | 0.3 | 0.4 | 1.2 | -0.3 | -0.6 | -0.7 | -1.1 | -0.7 | -0.4 | -0.3 | -0.3 | 0.3 | -0.8 |
Reaction time premature initiation rate | 0.8 | 1.0 | 2.0 | 0.9 | 1.2 | 1.2 | 0.7 | 1.2 | 1.0 | 0.8 | 1.0 | 0.4 | 1.4 |
Reaction time premature initiations | 0.4 | 0.6 | 1.6 | 0.7 | 0.8 | 0.8 | -0.0 | 0.8 | 1.3 | 0.7 | 0.7 | 0.1 | 1.0 |
Std. dev. reaction times | 0.9 | 1.2 | 2.3 | 1.2 | 0.9 | 1.1 | 0.8 | 1.0 | 1.5 | 1.2 | 1.1 | 0.3 | 1.2 |
Reaction time trials completed | 0.2 | 0.3 | 0.7 | -0.3 | -0.6 | -0.6 | -0.7 | -0.6 | 0.4 | -0.1 | -0.4 | -0.8 | -0.8 |
Reaction time trials AUC | 0.4 | 0.6 | 1.1 | -0.4 | -0.9 | -0.8 | -1.1 | -0.8 | 0.4 | -0.3 | -0.5 | -0.8 | -1.0 |
Social response proportion | 0.9 | 1.0 | 1.5 | -1.1 | -1.1 | -1.2 | -0.9 | -1.2 | -0.6 | -1.0 | -1.1 | -0.7 | -1.0 |
Social responses | 1.6 | 2.1 | 3.7 | -1.6 | -1.4 | -1.4 | -1.9 | -1.4 | 0.1 | -1.6 | -1.5 | -1.9 | -0.8 |
Social time | 0.0 | 0.0 | 0.2 | 0.0 | -0.1 | -0.1 | -0.3 | -0.1 | 0.4 | 0.1 | 0.2 | -0.2 | 0.3 |
Conditioned locomotion | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.5 | 0.4 | 0.3 | 0.2 | -0.1 | 0.4 |
Cocaine response after cond. corrected | 1.7 | 1.9 | 5.3 | 1.1 | 1.5 | 1.5 | 1.4 | 1.5 | -0.4 | 1.1 | 1.2 | 2.3 | 1.2 |
Cocaine response after cond. not corrected | 1.1 | 1.3 | 3.5 | 0.7 | 1.1 | 1.1 | 1.7 | 1.0 | -1.1 | 0.6 | 0.7 | 1.9 | 0.6 |
Cocaine response before conditioning | 1.7 | 2.0 | 2.7 | -1.4 | -1.4 | -1.5 | 0.0 | -1.5 | -1.7 | -1.5 | -1.4 | -1.4 | -1.6 |
Saline control response | 1.4 | 1.8 | 3.2 | 1.2 | 1.6 | 1.5 | 0.6 | 1.5 | 1.2 | 1.2 | 1.3 | 1.2 | 1.8 |
Condit. Reinf. active minus inactive responses | 2.2 | 2.7 | 3.8 | -1.5 | -1.9 | -1.9 | -1.7 | -2.0 | -0.3 | -1.4 | -1.6 | -1.8 | -1.7 |
Condit. Reinf. active-inactive response ratio | 1.1 | 1.1 | 2.4 | -0.7 | -1.2 | -1.2 | -1.6 | -1.3 | 0.4 | -0.7 | -0.8 | -1.1 | -1.1 |
Condit. Reinf. active responses | 3.0 | 4.1 | 6.9 | -1.9 | -2.2 | -2.3 | -2.0 | -2.3 | -0.3 | -1.9 | -2.0 | -2.6 | -1.9 |
Condit. Reinf. inactive responses | 1.8 | 2.2 | 3.7 | -1.4 | -1.6 | -1.7 | -1.4 | -1.7 | -0.5 | -1.4 | -1.5 | -1.9 | -1.3 |
Condit. Reinf. lever presses | 1.5 | 2.1 | 3.4 | -1.6 | -1.3 | -1.4 | -1.8 | -1.4 | -0.1 | -1.6 | -1.5 | -1.8 | -1.1 |
Condit. Reinf. lever reinforcers received | 2.7 | 3.7 | 6.0 | -1.9 | -2.1 | -2.2 | -1.6 | -2.2 | -0.6 | -1.9 | -2.0 | -2.5 | -1.8 |
Pavlov. Cond. lever latency | 2.8 | 3.8 | 5.8 | 2.3 | 1.9 | 1.9 | 1.6 | 1.9 | 0.8 | 2.2 | 2.2 | 2.4 | 1.8 |
Pavlov. Cond. magazine entry latency | 0.4 | 0.4 | 1.4 | -0.6 | -0.5 | -0.6 | 0.6 | -0.6 | -0.5 | -0.7 | -0.5 | -1.2 | -0.6 |
Pavlov. Cond. change in total contacts | 1.1 | 1.5 | 3.1 | -1.5 | -1.2 | -1.2 | -0.7 | -1.2 | -0.5 | -1.4 | -1.4 | -1.8 | -1.0 |
Pavlov. Cond. index score | 1.2 | 1.5 | 3.5 | -1.5 | -1.1 | -1.1 | -0.5 | -1.1 | -0.6 | -1.5 | -1.4 | -1.9 | -1.0 |
Pavlov. Cond. latency score | 1.1 | 1.4 | 3.2 | -1.5 | -1.0 | -1.1 | -0.5 | -1.1 | -0.6 | -1.5 | -1.4 | -1.8 | -0.8 |
Pavlov. Cond. lever contacts | 1.5 | 2.1 | 3.9 | -1.8 | -1.3 | -1.4 | -1.1 | -1.4 | -0.5 | -1.6 | -1.6 | -2.0 | -1.3 |
Pavlov. Cond. magazine entry number | 0.1 | 0.2 | 0.9 | 0.4 | 0.2 | 0.2 | -0.4 | 0.2 | 0.1 | 0.4 | 0.3 | 0.9 | 0.2 |
Pavlov. Cond. intertrial magazine entries | 0.6 | 0.8 | 5.9 | -0.7 | -0.4 | -0.4 | -2.4 | -0.4 | 0.7 | -0.7 | -0.7 | -0.2 | 0.1 |
Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.9 | 2.6 | -1.2 | -0.8 | -0.9 | -0.2 | -0.9 | -0.4 | -1.1 | -1.0 | -1.6 | -0.7 |
Pavlov. Cond. response bias | 2.3 | 3.1 | 5.4 | -2.0 | -1.7 | -1.8 | -0.8 | -1.8 | -1.0 | -1.9 | -1.9 | -2.3 | -1.8 |
Conditioned reinforcement - actives | 0.9 | 0.9 | 4.1 | 0.8 | 0.1 | 0.4 | 2.0 | 0.4 | -1.0 | 0.9 | 0.6 | 1.2 | -0.2 |
Conditioned reinforcement - inactives | 0.2 | 0.2 | 0.5 | -0.5 | 0.1 | 0.2 | 0.7 | 0.3 | -0.4 | -0.5 | -0.3 | -0.6 | 0.0 |
Conditioned locomotion | 0.6 | 0.7 | 2.6 | 0.0 | -0.1 | -0.2 | 1.5 | -0.1 | -1.6 | 0.2 | 0.1 | 1.0 | -0.8 |
Intermittent access intake day 1-15 change | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | -0.2 | -0.1 | -0.2 | 0.1 |
Intermittent access intake escalation | 0.1 | 0.1 | 0.4 | 0.2 | 0.5 | 0.3 | 0.0 | 0.3 | 0.1 | 0.2 | 0.3 | 0.6 | 0.4 |
Intermittent access intake escalation 2 | 0.2 | 0.2 | 0.3 | -0.5 | -0.3 | -0.6 | -0.6 | -0.5 | -0.5 | -0.4 | -0.4 | 0.2 | -0.5 |
Intermitt. access day 1 inactive lever presses | 0.6 | 0.7 | 2.1 | -1.1 | -0.2 | -0.2 | -0.8 | -0.2 | 0.2 | -1.2 | -0.9 | -1.4 | 0.3 |
Intermitt. access day 15 inactive lever presses | 0.8 | 0.9 | 2.7 | 0.5 | 1.0 | 0.9 | -0.8 | 1.0 | 1.6 | 0.5 | 0.6 | 0.1 | 1.4 |
Intermitt. access escalation Index | 0.3 | 0.3 | 0.6 | -0.7 | -0.5 | -0.6 | -0.1 | -0.7 | -0.4 | -0.6 | -0.5 | -0.3 | -0.7 |
Intermittent access day 1 total infusions | 0.2 | 0.2 | 1.0 | 0.2 | 0.3 | 0.4 | 1.0 | 0.5 | -0.2 | 0.2 | 0.3 | 0.3 | 0.3 |
Intermittent access day 15 total infusions | 0.3 | 0.3 | 0.7 | 0.4 | 0.7 | 0.5 | 0.8 | 0.6 | 0.1 | 0.4 | 0.5 | 0.6 | 0.5 |
Intermittent access terminal intake (last 3 days) | 0.2 | 0.2 | 0.4 | 0.2 | 0.6 | 0.4 | 0.6 | 0.4 | 0.1 | 0.2 | 0.3 | 0.3 | 0.5 |
Intermittent access total infusions | 0.3 | 0.3 | 1.6 | 0.2 | 0.6 | 0.5 | 1.3 | 0.5 | -0.2 | 0.3 | 0.4 | 0.4 | 0.3 |
Intermittent access day 1 locomotion | 1.2 | 1.2 | 3.5 | 0.7 | 1.2 | 1.2 | 1.9 | 1.3 | -0.1 | 0.8 | 0.9 | 0.8 | 1.0 |
Intermittent access day 15 total locomotion | 0.1 | 0.1 | 0.5 | -0.3 | -0.0 | -0.0 | 0.1 | 0.0 | 0.1 | -0.3 | -0.2 | -0.7 | -0.1 |
Intermittent access total locomotion | 0.4 | 0.5 | 1.6 | 0.4 | 0.7 | 0.8 | 1.3 | 0.8 | -0.2 | 0.6 | 0.7 | 0.7 | 0.3 |
Intermittent access standard deviation | 0.2 | 0.3 | 0.5 | -0.5 | -0.4 | -0.7 | 0.5 | -0.7 | -0.5 | -0.4 | -0.4 | -0.5 | -0.5 |
Cocaine induced anxiety | 0.7 | 0.8 | 3.5 | 0.7 | 0.5 | 0.5 | 1.9 | 0.5 | -0.9 | 0.7 | 0.6 | 1.3 | 0.2 |
Post-drug Anxiety | 0.2 | 0.2 | 1.0 | 0.0 | -0.1 | 0.1 | 1.0 | 0.1 | -0.7 | 0.1 | -0.0 | 0.2 | -0.2 |
Baseline Anxiety | 0.9 | 1.0 | 3.1 | -1.1 | -0.7 | -0.7 | -1.1 | -0.7 | 0.3 | -1.1 | -1.0 | -1.8 | -0.3 |
Lifetime Intake | 0.5 | 0.6 | 2.3 | 0.4 | 0.9 | 0.8 | 1.5 | 0.9 | -0.1 | 0.5 | 0.6 | 0.5 | 0.7 |
Incentive Sensitization - Responses | 0.3 | 0.3 | 1.8 | -0.0 | 0.1 | 0.0 | -1.2 | 0.1 | 1.3 | 0.1 | 0.1 | -0.2 | -0.1 |
Incentive Sensitization - Breakpoint | 0.3 | 0.3 | 1.5 | -0.2 | -0.0 | -0.1 | -1.1 | -0.1 | 1.2 | -0.1 | -0.1 | -0.4 | -0.2 |
Progressive ratio test 1 active lever presses | 0.9 | 0.9 | 2.1 | 0.7 | 1.1 | 1.1 | 1.4 | 1.1 | 0.2 | 0.6 | 0.7 | 0.6 | 1.2 |
Progressive ratio test 1 breakpoint | 1.1 | 1.1 | 2.2 | 0.8 | 1.3 | 1.3 | 1.5 | 1.3 | 0.3 | 0.7 | 0.9 | 0.6 | 1.4 |
Progressive ratio test 1 inactive lever presses | 0.4 | 0.4 | 1.0 | -0.7 | 0.5 | 0.5 | 1.0 | 0.5 | -0.5 | -0.7 | -0.5 | -0.6 | 0.7 |
Progressive ratio test 2 active lever presses | 0.5 | 0.5 | 1.5 | 0.5 | 0.8 | 0.7 | -0.2 | 0.7 | 1.2 | 0.6 | 0.6 | 0.4 | 0.8 |
Progressive ratio test 2 breakpoint | 0.5 | 0.5 | 1.6 | 0.4 | 0.9 | 0.8 | -0.2 | 0.8 | 1.3 | 0.5 | 0.6 | 0.2 | 0.7 |
Progressive ratio test 2 inactive lever presses | 0.2 | 0.3 | 0.7 | -0.8 | -0.3 | -0.4 | -0.3 | -0.4 | -0.3 | -0.8 | -0.7 | -0.6 | -0.1 |
Total sessions with >9 infusions | 1.1 | 1.2 | 2.5 | 0.5 | 1.4 | 1.5 | 1.1 | 1.5 | 0.3 | 0.6 | 0.8 | 0.8 | 1.6 |
Short access day 1 total inactive lever presses | 1.0 | 1.1 | 2.5 | -1.6 | -0.7 | -0.3 | 0.7 | -0.2 | -1.4 | -1.5 | -1.2 | -1.1 | -0.9 |
Short access day 10 total inactive lever presses | 0.8 | 0.8 | 3.5 | -1.2 | -0.3 | -0.1 | -1.9 | -0.1 | 0.2 | -1.3 | -1.0 | -0.7 | 0.2 |
Short access day 1 total infusions | 0.5 | 0.6 | 1.8 | 0.2 | 0.9 | 1.0 | 1.4 | 1.0 | -0.1 | 0.2 | 0.4 | 0.2 | 0.9 |
Short access day 10 total infusions | 0.8 | 0.9 | 3.3 | 0.9 | 0.8 | 0.9 | 1.8 | 0.9 | -0.3 | 0.9 | 0.7 | 0.9 | 0.5 |
Short access total infusions | 1.3 | 1.5 | 3.4 | 0.8 | 1.4 | 1.5 | 1.8 | 1.5 | 0.1 | 0.8 | 1.0 | 0.9 | 1.4 |
Short access day 1 locomotion | 0.7 | 0.7 | 1.6 | 0.2 | 1.1 | 1.1 | 1.0 | 1.1 | 0.6 | 0.3 | 0.6 | 0.0 | 1.3 |
Short access day 10 total locomotion | 0.2 | 0.2 | 0.9 | 0.4 | 0.5 | 0.4 | 0.9 | 0.4 | -0.1 | 0.5 | 0.5 | 0.5 | 0.3 |
Short access total locomotion | 3.6 | 3.7 | 5.3 | 1.7 | 2.3 | 2.2 | 1.8 | 2.2 | 1.0 | 1.8 | 2.0 | 1.7 | 2.1 |
Compulsive drug intake | 1.1 | 1.1 | 2.3 | -1.5 | -0.9 | -0.7 | -0.5 | -0.7 | -0.9 | -1.5 | -1.4 | -1.1 | -0.7 |
One hour access (0.3 mA shock) | 0.3 | 0.4 | 0.8 | -0.9 | -0.1 | 0.2 | 0.8 | 0.2 | -0.6 | -0.8 | -0.7 | -0.8 | -0.1 |
One hour access (shock baseline) | 0.3 | 0.3 | 1.5 | 0.2 | 0.7 | 0.7 | 1.2 | 0.7 | -0.2 | 0.3 | 0.4 | 0.4 | 0.4 |
Number of responses in last shaping day | 0.3 | 0.3 | 1.2 | 0.1 | 0.5 | 0.6 | 1.1 | 0.6 | -0.0 | 0.1 | 0.1 | -0.2 | 0.6 |
Context. condit. distance diff. score | 0.2 | 0.3 | 0.6 | -0.4 | -0.6 | -0.6 | -0.1 | -0.6 | -0.7 | -0.5 | -0.5 | -0.4 | -0.7 |
Locomotion velocity, session 1 | 0.3 | 0.3 | 1.2 | 0.6 | 0.1 | -0.1 | 1.1 | -0.1 | -0.5 | 0.6 | 0.5 | 0.7 | -0.1 |
Locomotion distance, session 1 | 1.8 | 2.3 | 4.3 | 1.7 | 1.4 | 1.3 | 2.1 | 1.4 | 0.3 | 1.7 | 1.7 | 1.6 | 1.1 |
Locomotion velocity, session 2 | 1.0 | 1.2 | 2.5 | 1.2 | 1.0 | 1.0 | 1.2 | 0.9 | -0.0 | 1.1 | 1.2 | 1.6 | 1.2 |
Locomotion distance, session 2 | 0.2 | 0.3 | 0.8 | 0.5 | 0.5 | 0.4 | -0.6 | 0.4 | 0.5 | 0.5 | 0.5 | 0.9 | 0.3 |
Locomotion velocity, session 3 | 1.0 | 1.2 | 4.8 | 0.8 | 1.2 | 1.1 | 2.2 | 1.0 | -0.3 | 0.8 | 1.0 | 0.8 | 0.8 |
Locomotion distance, session 3 | 0.4 | 0.4 | 1.4 | 0.6 | 0.6 | 0.5 | 1.2 | 0.5 | -0.4 | 0.5 | 0.5 | 0.7 | 0.3 |
Stereotopy head waving bouts, day 3 | 1.2 | 1.4 | 2.1 | 1.3 | 1.2 | 1.2 | 0.8 | 1.2 | 0.9 | 1.4 | 1.4 | 1.1 | 0.9 |
Stereotopy head waving duration, day 3 | 2.0 | 2.4 | 3.2 | 1.6 | 1.7 | 1.6 | 1.1 | 1.6 | 1.4 | 1.7 | 1.7 | 1.3 | 1.8 |
Locomotion velocity, session 7 | 0.1 | 0.1 | 0.2 | -0.1 | -0.1 | -0.1 | 0.5 | -0.2 | -0.4 | -0.2 | -0.1 | -0.2 | 0.2 |
Locomotion distance, session 7 | 0.4 | 0.5 | 0.8 | -0.8 | -0.7 | -0.7 | -0.9 | -0.7 | -0.8 | -0.9 | -0.8 | -0.2 | -0.7 |
Stereotopy head waving bouts, day 7 | 0.6 | 0.6 | 1.3 | 1.0 | 0.5 | 0.5 | 1.0 | 0.5 | 1.2 | 1.0 | 0.9 | -0.3 | 0.5 |
Stereotopy head waving duration, day 7 | 0.9 | 1.1 | 2.3 | 1.1 | 0.8 | 0.7 | 1.5 | 0.7 | 1.4 | 1.1 | 1.0 | -0.6 | 0.9 |
Locomotion velocity, session 8 | 0.5 | 0.6 | 2.4 | -0.4 | -0.4 | -0.5 | 1.0 | -0.5 | -1.5 | -0.5 | -0.4 | -0.0 | -1.1 |
Locomotion distance, session 8 | 0.4 | 0.6 | 2.5 | -0.4 | -0.6 | -0.7 | 0.3 | -0.7 | -1.6 | -0.5 | -0.5 | 0.3 | -1.1 |
Degree of sensitization distance | 1.7 | 1.7 | 4.2 | -1.4 | -1.3 | -1.3 | -2.0 | -1.3 | -0.6 | -1.4 | -1.4 | -0.8 | -1.0 |
Degree of sensitization stereotypy | 0.4 | 0.4 | 1.6 | 0.6 | 0.3 | 0.3 | 0.6 | 0.3 | 1.3 | 0.6 | 0.5 | -0.8 | 0.5 |
Condit. Reinf. active minus inactive responses | 1.2 | 1.3 | 4.0 | -0.9 | -1.0 | -1.0 | 0.6 | -1.1 | -2.0 | -0.9 | -1.0 | -0.5 | -1.5 |
Condit. Reinf. active-inactive response ratio | 0.6 | 0.6 | 2.4 | -0.1 | -0.7 | -0.6 | 1.0 | -0.7 | -1.5 | -0.2 | -0.3 | 0.1 | -1.1 |
Condit. Reinf. active responses | 2.6 | 3.2 | 4.1 | -1.9 | -1.8 | -1.8 | -1.0 | -1.9 | -1.8 | -1.9 | -2.0 | -1.5 | -2.0 |
Condit. Reinf. inactive responses | 3.3 | 3.9 | 5.7 | -2.4 | -1.9 | -1.9 | -2.3 | -1.9 | -0.8 | -2.2 | -2.3 | -2.0 | -1.7 |
Incentive salience index mean | 0.9 | 1.1 | 3.8 | -0.9 | -1.0 | -1.0 | 0.3 | -1.0 | -2.0 | -0.9 | -0.9 | -0.3 | -1.4 |
Condit. Reinf. lever presses | 0.3 | 0.4 | 1.6 | -0.6 | -0.5 | -0.5 | 0.1 | -0.5 | -1.3 | -0.6 | -0.5 | 0.0 | -0.9 |
Time in familiar zone, hab. session 1 | 0.3 | 0.3 | 1.4 | 0.4 | -0.1 | -0.0 | -1.2 | -0.0 | 1.1 | 0.4 | 0.2 | -0.1 | 0.1 |
Time in novel zone, hab. session 1 | 0.8 | 0.8 | 3.3 | -0.6 | -0.3 | -0.4 | 1.8 | -0.4 | -1.5 | -0.6 | -0.5 | -0.5 | -0.7 |
Total zone transitions, hab. session 1 | 0.9 | 1.3 | 2.1 | 1.0 | 1.4 | 1.3 | 0.5 | 1.3 | 1.3 | 1.0 | 1.2 | 0.6 | 1.3 |
Total locomotion distance, hab. session 1 | 0.1 | 0.2 | 0.5 | -0.5 | -0.1 | -0.2 | 0.3 | -0.2 | -0.4 | -0.5 | -0.4 | -0.7 | -0.2 |
Locomotion velocity, hab. session 1 | 0.1 | 0.2 | 0.5 | -0.7 | -0.2 | -0.3 | -0.0 | -0.3 | -0.5 | -0.7 | -0.5 | -0.6 | -0.2 |
Time in familiar zone, hab. session 2 | 2.4 | 2.5 | 4.0 | -1.5 | -1.6 | -1.5 | 0.2 | -1.6 | -1.8 | -1.6 | -1.5 | -1.7 | -2.0 |
Time in novel zone, hab. session 2 | 1.0 | 1.0 | 1.6 | 1.2 | 0.8 | 0.7 | -0.3 | 0.8 | 1.2 | 1.2 | 1.0 | 1.2 | 1.1 |
Total zone transitions, hab. session 2 | 0.4 | 0.6 | 1.0 | 0.7 | 0.9 | 0.8 | 0.0 | 0.8 | 1.0 | 0.7 | 0.8 | 0.6 | 0.8 |
Total locomotion distance, hab. session 2 | 0.3 | 0.3 | 0.8 | -0.6 | -0.6 | -0.6 | -0.9 | -0.6 | -0.1 | -0.6 | -0.5 | -0.5 | -0.7 |
Locomotion velocity, hab. session 2 | 0.1 | 0.2 | 0.9 | -0.4 | -0.3 | -0.3 | -0.9 | -0.3 | 0.2 | -0.4 | -0.4 | -0.4 | -0.3 |
Novel to familiar place preference ratio | 1.6 | 1.7 | 2.3 | -1.2 | -1.5 | -1.5 | -0.4 | -1.5 | -1.1 | -1.1 | -1.4 | -1.4 | -1.3 |
Novelty place preference | 1.2 | 1.2 | 1.8 | -1.0 | -1.3 | -1.3 | -0.3 | -1.3 | -1.0 | -0.9 | -1.1 | -1.1 | -1.1 |
Time in novel zone, NPP test | 2.6 | 2.8 | 4.2 | -1.4 | -2.0 | -2.0 | -0.5 | -2.0 | -1.4 | -1.3 | -1.7 | -1.7 | -1.9 |
Total zone transitions, NPP test | 0.1 | 0.1 | 0.7 | -0.2 | 0.3 | 0.1 | -0.8 | 0.1 | 0.2 | -0.2 | -0.0 | 0.4 | 0.2 |
Total locomotion distance, NPP test | 0.1 | 0.2 | 0.5 | -0.6 | -0.1 | -0.3 | -0.7 | -0.3 | -0.3 | -0.6 | -0.4 | -0.1 | -0.3 |
Locomotion velocity, NPP test | 0.2 | 0.2 | 0.5 | -0.2 | 0.7 | 0.6 | -0.5 | 0.6 | -0.0 | -0.2 | 0.1 | 0.7 | 0.6 |
Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.8 | -0.1 | 0.3 | 0.2 | 0.9 | 0.2 | -0.2 | -0.1 | -0.1 | -0.4 | 0.4 |
Pavlov. Cond. magazine entry latency | 0.7 | 0.8 | 1.6 | -0.8 | -1.0 | -1.0 | -1.2 | -1.0 | -0.3 | -0.8 | -0.8 | -0.7 | -1.3 |
Pavlov. Cond. change in total contacts | 2.9 | 3.1 | 5.2 | -1.4 | -2.2 | -2.0 | -2.0 | -2.0 | -0.6 | -1.3 | -1.6 | -1.4 | -2.3 |
Pavlov. Cond. index score | 0.9 | 1.1 | 2.1 | -0.9 | -1.2 | -1.1 | -1.4 | -1.2 | -0.4 | -0.9 | -0.9 | -0.7 | -1.3 |
Pavlov. Cond. latency score | 0.7 | 0.9 | 1.6 | -0.8 | -1.1 | -1.0 | -1.3 | -1.0 | -0.3 | -0.8 | -0.8 | -0.6 | -1.2 |
Pavlov. Cond. lever contacts | 0.4 | 0.5 | 1.3 | -0.5 | -0.8 | -0.8 | -1.1 | -0.8 | 0.2 | -0.4 | -0.5 | -0.5 | -0.9 |
Pavlov. Cond. magazine entry number | 1.3 | 1.7 | 2.6 | 1.2 | 1.5 | 1.4 | 1.4 | 1.4 | 0.7 | 1.2 | 1.2 | 1.1 | 1.6 |
Pavlov. Cond. intertrial magazine entries | 1.3 | 1.5 | 4.3 | -1.4 | -1.1 | -1.2 | -2.1 | -1.2 | -0.4 | -1.3 | -1.4 | -0.7 | -0.8 |
Pavlov. Cond. lever-magazine prob. diff. | 1.2 | 1.5 | 2.3 | -1.1 | -1.5 | -1.3 | -1.5 | -1.3 | -0.5 | -1.0 | -1.1 | -0.9 | -1.5 |
Pavlov. Cond. response bias | 0.5 | 0.6 | 1.5 | -0.5 | -0.9 | -0.8 | -1.2 | -0.8 | -0.0 | -0.4 | -0.5 | -0.4 | -1.1 |
Bone: apparent density | 4.4 | 7.3 | 10.1 | -2.8 | -2.8 | -2.8 | -3.0 | -2.8 | -1.1 | -2.7 | -2.9 | -2.4 | -3.2 |
Bone surface | 2.8 | 5.0 | 8.5 | -2.0 | -2.5 | -2.4 | -2.8 | -2.4 | -0.6 | -2.0 | -2.2 | -1.8 | -2.9 |
Bone volume | 3.4 | 5.7 | 13.3 | -2.3 | -2.5 | -2.4 | -3.7 | -2.4 | -0.0 | -2.1 | -2.4 | -1.9 | -2.7 |
Bone: connectivity density | 1.4 | 2.1 | 3.9 | -1.4 | -1.7 | -1.6 | -0.8 | -1.5 | -1.1 | -1.5 | -1.5 | -1.3 | -2.0 |
Bone: cortical apparent density | 3.6 | 4.7 | 11.3 | 1.8 | 2.4 | 2.4 | 3.4 | 2.4 | -0.3 | 1.8 | 2.0 | 2.0 | 2.1 |
Bone: cortical area | 4.3 | 6.5 | 24.1 | -2.4 | -2.3 | -2.3 | -4.9 | -2.3 | 0.9 | -2.3 | -2.4 | -2.2 | -1.6 |
Bone: cortical porosity | 1.3 | 1.5 | 2.2 | -1.3 | -1.2 | -1.2 | -1.3 | -1.2 | -0.2 | -1.3 | -1.3 | -1.3 | -1.5 |
Bone: cortical porosity | 1.6 | 1.8 | 2.7 | -1.3 | -1.4 | -1.3 | -1.6 | -1.3 | 0.1 | -1.3 | -1.3 | -1.5 | -1.6 |
Bone: cortical thickness | 1.8 | 2.9 | 15.6 | -1.6 | -1.2 | -1.2 | -4.0 | -1.2 | 0.9 | -1.6 | -1.5 | -1.1 | -0.3 |
Bone: cortical thickness | 1.1 | 1.2 | 5.5 | 0.1 | 0.7 | 0.6 | -2.3 | 0.6 | 2.0 | 0.1 | 0.3 | 0.3 | 1.3 |
Bone: cortical tissue density | 3.7 | 4.9 | 12.8 | 1.8 | 2.4 | 2.4 | 3.6 | 2.4 | -0.4 | 1.8 | 2.0 | 2.0 | 2.0 |
Bone: elastic displacement | 0.9 | 1.1 | 2.1 | 1.0 | 1.0 | 0.9 | 0.0 | 1.0 | 1.3 | 1.0 | 1.0 | 1.0 | 1.4 |
Bone: elastic work | 1.4 | 1.8 | 4.4 | 1.3 | 1.2 | 1.2 | -1.1 | 1.2 | 2.1 | 1.3 | 1.3 | 1.4 | 1.1 |
Bone: endosteal estimation | 0.9 | 2.0 | 5.9 | -0.9 | -1.5 | -1.5 | -2.4 | -1.5 | 0.4 | -0.9 | -1.1 | -1.0 | -1.7 |
Bone: endosteal perimeter | 0.7 | 1.5 | 7.0 | -0.5 | -1.1 | -1.1 | -2.6 | -1.1 | 1.5 | -0.4 | -0.7 | -1.1 | -0.7 |
Bone: final force | 1.9 | 3.2 | 17.1 | -1.3 | -1.4 | -1.4 | -4.1 | -1.4 | 1.2 | -1.1 | -1.3 | -1.0 | -1.2 |
Bone: final moment | 2.4 | 3.9 | 18.8 | -1.5 | -1.7 | -1.7 | -4.3 | -1.7 | 1.0 | -1.4 | -1.6 | -1.2 | -1.6 |
Bone: marrow area | 1.0 | 2.1 | 6.5 | -1.0 | -1.5 | -1.6 | -2.5 | -1.6 | 0.4 | -0.9 | -1.2 | -1.1 | -1.7 |
Bone: maximum diameter | 3.2 | 5.9 | 13.3 | -2.3 | -2.4 | -2.5 | -3.6 | -2.4 | 0.5 | -2.2 | -2.4 | -2.8 | -2.0 |
Bone: maximum force | 2.1 | 3.6 | 16.9 | -1.4 | -1.7 | -1.7 | -4.1 | -1.7 | 0.7 | -1.3 | -1.5 | -1.0 | -1.8 |
Bone: maximum moment | 2.5 | 4.4 | 17.9 | -1.7 | -2.0 | -1.9 | -4.2 | -1.9 | 0.5 | -1.6 | -1.8 | -1.2 | -2.1 |
Bone: minimum diameter | 2.5 | 4.6 | 15.2 | -1.7 | -2.2 | -2.2 | -3.9 | -2.2 | 0.8 | -1.6 | -1.9 | -1.9 | -1.8 |
Bone: periosteal estimation | 2.8 | 5.8 | 21.7 | -2.0 | -2.3 | -2.3 | -4.7 | -2.3 | 0.8 | -1.9 | -2.1 | -1.8 | -2.0 |
Bone: periosteal perimeter | 2.5 | 4.1 | 18.9 | -1.4 | -1.8 | -1.8 | -4.4 | -1.8 | 1.7 | -1.3 | -1.5 | -1.8 | -1.0 |
Bone: post-yield work | 2.3 | 3.1 | 3.8 | -1.8 | -1.9 | -1.9 | -1.8 | -1.9 | -1.1 | -1.8 | -1.8 | -1.6 | -1.9 |
Bone: stiffness | 1.0 | 1.5 | 7.4 | -0.8 | -1.2 | -1.1 | -2.7 | -1.1 | 0.3 | -0.7 | -0.9 | -0.4 | -1.3 |
Bone: tissue strength | 0.2 | 0.2 | 0.5 | -0.2 | -0.2 | -0.1 | 0.7 | -0.1 | -0.4 | -0.2 | -0.2 | -0.5 | -0.7 |
Bone: trabecular number | 2.2 | 3.4 | 4.5 | -1.9 | -2.0 | -2.0 | -2.0 | -1.9 | -0.6 | -1.9 | -2.0 | -1.8 | -2.1 |
Bone: trabecular spacing | 0.5 | 0.6 | 4.0 | 0.3 | 0.3 | 0.3 | 2.0 | 0.3 | -1.1 | 0.2 | 0.3 | 0.2 | 0.6 |
Bone: trabecular thickness | 3.4 | 4.2 | 16.2 | -1.9 | -1.6 | -1.7 | -4.0 | -1.6 | 1.2 | -1.7 | -1.9 | -2.0 | -1.4 |
Bone: trabecular tissue density | 0.3 | 0.4 | 1.8 | 0.3 | 0.4 | 0.4 | 1.3 | 0.4 | -0.9 | 0.3 | 0.3 | 0.6 | 0.1 |
Breakpoint value in progressive ratio session | 0.6 | 0.7 | 1.8 | -1.1 | -0.5 | -0.3 | -1.2 | -0.2 | 0.3 | -1.1 | -1.0 | -1.3 | -0.2 |
Distance traveled before self-admin | 4.3 | 4.6 | 5.7 | 2.3 | 2.4 | 2.4 | 1.5 | 2.4 | 1.4 | 2.3 | 2.4 | 2.2 | 2.0 |
Distance traveled after self-admin | 2.1 | 2.3 | 3.3 | 1.4 | 1.8 | 1.8 | 1.8 | 1.8 | 0.3 | 1.4 | 1.3 | 1.5 | 1.4 |
Delta time in closed arm before/after self-admin | 0.2 | 0.2 | 1.1 | -0.3 | -0.2 | -0.3 | -0.1 | -0.3 | -1.1 | -0.3 | -0.3 | 0.5 | -0.5 |
Delta time in open arm before/after self-admin | 4.0 | 3.9 | 5.0 | -2.2 | -2.1 | -2.1 | -0.7 | -2.1 | -1.7 | -2.2 | -2.2 | -2.1 | -1.8 |
Diff in mean of infusions in LGA sessions | 0.1 | 0.1 | 0.5 | -0.1 | 0.0 | 0.3 | -0.2 | 0.4 | 0.7 | -0.1 | -0.1 | -0.6 | 0.1 |
Extinction: sum of active levers before priming | 0.4 | 0.4 | 1.3 | -0.7 | -0.3 | -0.3 | 0.4 | -0.4 | -0.6 | -0.8 | -0.7 | -1.1 | -0.2 |
Active lever presses in extinction session 6 | 0.6 | 0.6 | 1.8 | 0.2 | 0.8 | 0.9 | -0.8 | 1.0 | 1.3 | 0.1 | 0.2 | -0.2 | 1.0 |
Delta distance traveled before/after self-admin | 0.2 | 0.2 | 0.6 | -0.5 | -0.3 | -0.3 | 0.7 | -0.3 | -0.8 | -0.5 | -0.4 | -0.2 | -0.4 |
Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 0.7 | -0.7 | -0.3 | -0.3 | 0.6 | -0.3 | -0.8 | -0.7 | -0.7 | -0.5 | -0.3 |
Time in closed arm before self-admin | 0.4 | 0.5 | 0.9 | 0.9 | 0.6 | 0.7 | 0.6 | 0.7 | 0.8 | 0.9 | 0.8 | 0.3 | 0.5 |
Time in closed arm after self-admin | 0.6 | 0.6 | 1.2 | 0.9 | 0.7 | 0.8 | 0.8 | 0.8 | 0.0 | 0.8 | 0.8 | 1.1 | 0.2 |
Time in open arm before self-admin | 0.3 | 0.3 | 1.1 | 0.7 | 0.4 | 0.4 | 1.1 | 0.3 | -0.1 | 0.7 | 0.6 | 0.6 | 0.3 |
Time in open arm after self-admin | 1.1 | 1.3 | 1.9 | -1.0 | -1.3 | -1.3 | 0.2 | -1.4 | -1.0 | -1.0 | -1.1 | -1.3 | -1.1 |
Sum of active levers in priming session hrs 5-6 | 0.3 | 0.3 | 0.6 | -0.8 | -0.2 | 0.0 | 0.1 | 0.0 | -0.5 | -0.8 | -0.8 | -0.7 | -0.1 |
Time to tail flick, vehicle, before self-admin | 1.5 | 1.5 | 2.2 | -1.4 | -1.2 | -1.4 | -0.7 | -1.5 | -0.9 | -1.4 | -1.3 | -1.2 | -1.0 |
Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.6 | -0.1 | -0.1 | -0.3 | -0.8 | -0.2 | 0.2 | -0.2 | -0.1 | 0.0 | -0.1 |
Time to tail flick, test, before self-admin | 2.2 | 2.2 | 2.9 | 1.5 | 1.5 | 1.7 | 1.3 | 1.7 | 0.8 | 1.5 | 1.5 | 1.6 | 1.4 |
Time to tail flick, test, after self-admin | 1.2 | 1.2 | 2.2 | -1.5 | -0.9 | -1.0 | -0.4 | -1.0 | -0.8 | -1.5 | -1.3 | -1.5 | -0.5 |
Delta time to tail flick, vehicle, before/after SA | 1.0 | 1.0 | 3.1 | 1.1 | 0.9 | 0.8 | -0.8 | 0.9 | 1.8 | 1.0 | 0.9 | 0.5 | 0.9 |
Delta time to tail flick, test, before/after SA | 5.7 | 5.1 | 6.4 | -2.5 | -2.2 | -2.5 | -2.0 | -2.5 | -1.4 | -2.5 | -2.5 | -2.2 | -2.0 |
Ambulatory time before self-admin | 2.8 | 2.9 | 3.9 | 1.8 | 1.9 | 2.0 | 1.1 | 2.0 | 1.2 | 1.8 | 1.8 | 1.7 | 1.7 |
Ambulatory time after self-admin | 2.1 | 2.3 | 4.7 | 1.2 | 1.9 | 1.8 | 2.2 | 1.9 | 0.2 | 1.2 | 1.3 | 1.3 | 1.5 |
Total heroin consumption | 0.7 | 0.8 | 4.2 | -0.6 | -0.2 | -0.1 | -2.1 | 0.0 | 1.3 | -0.6 | -0.5 | -1.1 | -0.1 |
Area under the delay curve | 1.2 | 1.2 | 3.6 | 1.3 | 1.1 | 1.0 | 0.3 | 1.0 | 1.9 | 1.3 | 1.3 | 0.0 | 0.8 |
Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 0.8 | 0.6 | 0.6 | 0.3 | -0.7 | 0.3 | 0.9 | 0.6 | 0.6 | 0.6 | 0.2 |
Delay disc. indifference point, 16s delay | 0.8 | 0.8 | 2.3 | 1.3 | 0.5 | 0.4 | 0.4 | 0.4 | 1.5 | 1.3 | 1.1 | 0.0 | 0.3 |
Delay disc. indifference point, 2s delay | 1.7 | 1.9 | 2.5 | 1.6 | 1.6 | 1.4 | 0.9 | 1.4 | 1.4 | 1.6 | 1.6 | 0.9 | 1.1 |
Delay disc. indifference point, 24s delay | 0.7 | 0.7 | 2.2 | 0.9 | 0.8 | 0.7 | 0.1 | 0.7 | 1.5 | 0.9 | 0.9 | -0.1 | 0.7 |
Delay disc. indifference point, 4s delay | 0.9 | 1.0 | 2.6 | 1.2 | 0.9 | 0.8 | 0.3 | 0.8 | 1.6 | 1.2 | 1.2 | 0.1 | 0.7 |
Delay disc. indifference point, 8s delay | 1.4 | 1.4 | 2.6 | 1.2 | 1.3 | 1.3 | 0.7 | 1.3 | 1.6 | 1.3 | 1.3 | 0.2 | 1.0 |
Delay discount exponential model param | 1.5 | 1.6 | 4.3 | -1.5 | -1.2 | -1.1 | -0.4 | -1.1 | -2.1 | -1.5 | -1.4 | -0.1 | -1.0 |
Delay discount hyperbolic model param | 1.6 | 1.7 | 4.2 | -1.5 | -1.3 | -1.2 | -0.5 | -1.2 | -2.1 | -1.6 | -1.5 | -0.2 | -1.0 |
Fecal boli incidents, locomotor time 1 | 0.3 | 0.3 | 0.8 | 0.1 | -0.9 | -0.9 | -0.4 | -0.9 | 0.1 | 0.1 | -0.2 | -0.5 | -0.7 |
Change in fecal boli incidents, locomotor task | 1.0 | 0.9 | 1.6 | -1.3 | -0.9 | -0.9 | -1.2 | -0.9 | -0.6 | -1.3 | -1.2 | -0.6 | -0.6 |
Time >=10cm from walls, locomotor time 1 | 0.1 | 0.1 | 0.4 | -0.3 | -0.3 | -0.4 | 0.3 | -0.4 | -0.6 | -0.3 | -0.3 | -0.2 | -0.4 |
Bouts of movement, locomotor time 1 | 0.8 | 0.9 | 1.6 | -1.2 | -0.8 | -1.0 | -0.7 | -1.0 | -0.9 | -1.3 | -1.1 | -0.8 | -0.5 |
Total resting periods, locomotor time 1 | 0.5 | 0.5 | 0.9 | -0.9 | -0.6 | -0.7 | -0.8 | -0.7 | -0.7 | -1.0 | -0.9 | -0.4 | -0.3 |
Rest time, locomotor task time 1 | 0.3 | 0.4 | 1.8 | -0.0 | 0.1 | 0.2 | -1.2 | 0.2 | -0.4 | -0.0 | -0.0 | 1.3 | 0.3 |
Distance moved, locomotor task time 1 | 0.7 | 0.7 | 1.2 | 0.7 | 1.1 | 0.9 | 1.1 | 0.9 | 1.1 | 0.7 | 0.8 | -0.2 | 0.6 |
Vertical activity count, locomotor time 1 | 0.9 | 0.9 | 1.8 | 0.9 | 1.2 | 1.0 | 1.3 | 1.0 | 0.9 | 0.9 | 1.0 | -0.0 | 0.7 |
Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.3 | -0.4 | -0.0 | -0.1 | -0.5 | -0.1 | -0.3 | -0.4 | -0.3 | -0.2 | 0.0 |
Bouts of movement, locomotor time 2 | 0.1 | 0.1 | 0.4 | 0.4 | 0.2 | 0.2 | 0.4 | 0.2 | -0.1 | 0.4 | 0.3 | 0.7 | 0.4 |
Total resting periods, locomotor time 2 | 0.2 | 0.2 | 0.5 | 0.5 | 0.5 | 0.4 | 0.5 | 0.4 | -0.0 | 0.5 | 0.5 | 0.7 | 0.6 |
Rest time, locomotor task time 2 | 0.1 | 0.1 | 0.6 | 0.3 | 0.3 | 0.4 | 0.1 | 0.4 | -0.2 | 0.3 | 0.3 | 0.8 | 0.3 |
Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.3 | -0.0 | 0.6 | 0.4 | 0.2 | 0.4 | 0.3 | -0.0 | 0.1 | -0.2 | 0.4 |
Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.2 | -0.4 | 0.2 | 0.0 | 0.4 | 0.0 | -0.3 | -0.4 | -0.2 | -0.4 | 0.1 |
Weight adjusted by age | 1.4 | 1.5 | 9.2 | -0.7 | -1.1 | -1.2 | -3.0 | -0.9 | 0.6 | -0.8 | -0.8 | -0.4 | -0.6 |
Seeking ratio, delayed vs. immediate footshock | 1.4 | 1.6 | 10.7 | 0.4 | 0.6 | 0.7 | 3.3 | 0.8 | -1.6 | 0.4 | 0.5 | 0.5 | 0.3 |
Locomotion in novel chamber | 0.7 | 0.9 | 1.8 | 0.6 | 1.2 | 1.2 | -0.5 | 1.3 | 0.9 | 0.6 | 0.8 | 0.9 | 1.0 |
Locomotion in novel chamber post-restriction | 2.9 | 3.5 | 5.1 | 1.9 | 2.2 | 2.3 | 0.5 | 2.2 | 1.4 | 1.9 | 2.0 | 1.9 | 1.7 |
Progressive ratio | 2.0 | 2.3 | 5.4 | 1.3 | 1.6 | 1.6 | 2.3 | 1.8 | 0.3 | 1.3 | 1.4 | 1.1 | 1.6 |
Food seeking constrained by brief footshock | 2.1 | 2.6 | 11.7 | 1.2 | 1.5 | 1.7 | 3.4 | 1.6 | -0.1 | 1.2 | 1.3 | 0.4 | 1.2 |
Seeking ratio, punishment vs. effort | 0.0 | 0.1 | 0.2 | -0.2 | -0.2 | -0.1 | -0.0 | -0.3 | -0.3 | -0.2 | -0.2 | -0.2 | -0.4 |
Run reversals in cocaine runway, females | 0.3 | 0.2 | 0.9 | 0.2 | 0.4 | 0.5 | 1.0 | 0.5 | 0.4 | 0.1 | 0.2 | -0.5 | 0.6 |
Run reversals in cocaine runway, males | 2.4 | 2.3 | 3.9 | 1.4 | 2.0 | 1.8 | 0.9 | 1.7 | 0.9 | 1.3 | 1.5 | 1.6 | 1.7 |
Latency to leave start box in cocaine runway | 0.1 | 0.1 | 0.6 | 0.1 | 0.0 | 0.0 | 0.8 | -0.0 | 0.2 | 0.2 | 0.1 | -0.3 | -0.1 |
Latency to leave start box in cocaine runway, F | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.4 | -0.2 | -0.3 | -0.0 | -0.2 | -0.2 | -0.4 | -0.5 |
Latency to leave start box in cocaine runway, M | 0.4 | 0.4 | 1.2 | 0.6 | 0.6 | 0.6 | 1.1 | 0.5 | 0.6 | 0.7 | 0.6 | 0.3 | 0.5 |
Cd content in liver | 0.8 | 0.9 | 3.8 | -1.1 | -0.5 | -0.4 | 0.7 | -0.5 | -2.0 | -1.2 | -0.9 | -0.4 | -0.6 |
Co content in liver | 0.0 | 0.0 | 0.2 | -0.1 | 0.2 | 0.1 | -0.3 | 0.2 | -0.2 | 0.0 | 0.0 | 0.4 | 0.0 |
Cu content in liver | 0.1 | 0.1 | 0.5 | -0.1 | -0.0 | -0.1 | -0.6 | -0.1 | 0.7 | 0.1 | -0.0 | -0.3 | 0.0 |
Fe content in liver | 0.1 | 0.1 | 0.3 | -0.3 | -0.1 | -0.3 | -0.0 | -0.2 | -0.1 | -0.3 | -0.2 | -0.5 | 0.4 |
K content in liver | 0.2 | 0.2 | 0.7 | 0.1 | 0.3 | 0.4 | -0.3 | 0.3 | 0.7 | 0.2 | 0.1 | 0.0 | 0.8 |
Mg content in liver | 1.1 | 1.1 | 2.8 | 0.8 | 0.9 | 1.1 | -0.1 | 1.0 | 1.6 | 1.0 | 0.9 | 0.5 | 1.7 |
Mn content in liver | 0.1 | 0.1 | 0.2 | 0.0 | 0.4 | 0.4 | -0.5 | 0.3 | 0.2 | 0.0 | 0.1 | 0.5 | 0.3 |
Na content in liver | 0.5 | 0.6 | 2.3 | 0.3 | 0.1 | 0.1 | -1.3 | 0.1 | 1.5 | 0.4 | 0.3 | -0.2 | 1.0 |
Rb content in liver | 0.9 | 1.1 | 1.7 | 1.1 | 1.0 | 1.1 | 1.3 | 1.1 | 0.9 | 1.2 | 1.1 | 0.5 | 1.2 |
Se content in liver | 0.2 | 0.2 | 1.0 | 0.4 | 0.3 | 0.5 | 0.5 | 0.4 | 0.2 | 0.3 | 0.4 | 0.2 | 1.0 |
Sr content in liver | 7.0 | 6.4 | 8.2 | 2.7 | 2.9 | 2.8 | 1.9 | 2.8 | 0.8 | 2.5 | 2.8 | 2.8 | 2.6 |
Zn content in liver | 2.5 | 2.7 | 4.6 | 1.7 | 1.5 | 1.6 | 0.0 | 1.5 | 1.4 | 1.8 | 1.7 | 2.1 | 2.1 |