Nr2c1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	alternative polyA	ENSRNOT00000009578	0.2	0.11	5.6e-03	0.19	0.05	0.09	0.13	2.6e-05	2.9e-02	4.1e-03	4.9e-04
2	LHb	alternative polyA	ENSRNOT00000089228	0.32	0.15	1.8e-03	0.21	0.08	0.13	0.15	8.9e-06	6.8e-03	6.3e-04	1.9e-04
3	Liver	gene expression	ENSRNOG00000006983	0.04	0.02	1.7e-04	0.03	0.03	0.03	0.03	7.4e-04	7.0e-04	2.0e-04	8.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	1.1	3.4	4.9	2.2	-2.2	-0.7
BMI without tail	3.6	7.6	9.3	3.0	-3.0	-2.0
Body weight	8.3	35.1	37.8	6.1	-6.1	-5.5
Epididymis fat weight	3.0	6.9	9.2	3.0	-3.0	-1.5
Glucose	0.0	0.0	0.1	-0.1	0.1	-0.3
Heart weight	0.2	0.2	0.6	-0.1	0.1	0.8
Left kidney weight	2.8	8.0	8.3	2.9	-2.9	-2.7
Right kidney weight	1.7	4.9	5.5	2.3	-2.3	-1.9
Tail length	8.5	25.6	25.7	5.1	-5.1	-5.0
Length with tail	11.9	43.6	44.5	6.7	-6.7	-6.5
Length without tail	5.4	11.8	12.3	3.5	-3.5	-3.3
Liver weight, left	1.0	1.7	2.4	1.6	-1.6	-0.3
Liver weight, right	0.9	1.6	2.2	1.5	-1.5	-0.5
Parametrial fat weight	0.6	1.2	3.4	0.2	-0.2	1.8
Retroperitoneal fat weight	3.4	11.3	15.7	4.0	-4.0	-1.6
Intraocular pressure	1.3	1.8	2.7	-1.6	1.6	0.4
Extensor digitorum longus weight	0.1	0.4	0.5	-0.7	0.7	-0.4
Soleus weight	0.0	0.0	0.0	-0.2	0.2	0.2
Tibialis anterior weight	0.6	1.9	2.3	-1.5	1.5	1.1
Tibia length	9.2	25.8	28.4	5.3	-5.3	-4.5
Number of licking bursts	0.1	0.1	0.2	-0.4	0.4	-0.2
Food consumed during 24 hour testing period	0.4	0.5	0.8	0.6	-0.6	-0.9
Times rat made contact with spout	2.0	2.3	6.9	0.1	-0.1	-2.6
Mean time between licks in bursts	0.4	0.6	0.8	0.9	-0.9	-0.1
Mean num. licks in bursts	0.2	0.3	0.9	-0.1	0.1	-0.9
Std. dev. time between licks in bursts	0.8	0.9	2.3	0.5	-0.5	1.5
Water consumed over 24 hours	0.6	0.7	1.6	-0.5	0.5	-1.3
Indifference point 0 sec	0.1	0.1	0.2	-0.4	0.4	0.1
Indifference point AUC	0.3	0.4	1.0	-0.3	0.3	-1.0
Indifference point function ln k	0.4	0.6	0.6	0.8	-0.8	0.7
Indifference point function log k	0.4	0.6	0.6	0.8	-0.8	0.7
Delay discounting total patch changes 0 sec	0.1	0.1	0.1	-0.4	0.4	0.1
Delay discounting total patch changes 12 sec	0.6	0.9	2.6	0.1	-0.1	-1.6
Delay discounting total patch changes 18 sec	0.7	0.9	1.9	-0.6	0.6	-1.4
Delay discounting total patch changes 24 sec	0.7	0.9	2.7	0.2	-0.2	-1.6
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	-0.6	0.6	-0.2
Delay discounting time to switch 0 sec	0.3	0.5	0.7	-0.9	0.9	-0.0
Delay discounting water rate 0 sec	1.9	3.1	4.1	2.0	-2.0	-1.0
Delay discounting water rate 12 sec	1.3	2.0	3.6	1.1	-1.1	-1.9
Delay discounting water rate 18 sec	0.0	0.0	0.1	0.1	-0.1	0.3
Delay discounting water rate 24 sec	3.5	4.8	6.2	2.5	-2.5	-1.4
Delay discounting water rate 6 sec	5.2	7.5	9.5	3.1	-3.1	-1.9
Locomotor activity	4.5	7.1	8.6	2.9	-2.9	-2.0
Locomotor testing distance	1.8	3.0	4.0	2.0	-2.0	-1.0
Locomotor testing rearing	0.2	0.3	0.5	0.5	-0.5	-0.7
Light reinforcement 1	1.2	2.2	3.1	1.8	-1.8	-0.5
Light reinforcement 2	0.5	0.6	0.7	-0.8	0.8	0.8
Reaction time number correct	0.2	0.2	0.3	0.5	-0.5	0.3
Reaction time mean minus median	0.5	0.6	0.7	-0.8	0.8	0.7
Reaction time mean minus median AUC	0.6	0.8	1.1	-1.1	1.1	0.4
Reaction time num false alarms	1.4	1.9	2.7	-1.6	1.6	0.6
Reaction time num false alarms AUC	1.9	2.7	3.4	-1.8	1.8	1.1
Reaction time trials correct on left	0.2	0.2	0.3	0.5	-0.5	0.3
Reaction time trials on left	0.1	0.2	0.2	0.5	-0.5	0.3
Reaction time mean	0.2	0.2	0.3	-0.6	0.6	0.3
Reaction time mean AUC	0.2	0.2	0.4	-0.6	0.6	-0.0
Median of all reaction times	0.0	0.0	0.1	-0.3	0.3	0.0
Reaction time omissions	2.4	3.2	4.5	-1.6	1.6	2.1
Reaction time false alarm rate	2.1	2.9	4.0	-2.0	2.0	0.9
Reaction time premature initiation rate	0.1	0.1	0.2	0.3	-0.3	0.4
Reaction time premature initiations	0.2	0.2	0.4	0.6	-0.6	0.1
Std. dev. reaction times	1.0	1.3	1.6	-1.3	1.3	0.9
Reaction time trials completed	0.1	0.2	0.2	0.5	-0.5	0.3
Reaction time trials AUC	0.1	0.2	0.3	0.5	-0.5	0.3
Social response proportion	1.5	1.6	2.4	1.5	-1.5	-0.3
Social responses	2.5	3.3	4.7	2.2	-2.2	-0.6
Social time	0.7	0.9	1.8	-0.7	0.7	-1.3
Conditioned locomotion	0.1	0.1	0.2	0.0	-0.0	0.5
Cocaine response after cond. corrected	0.4	0.5	0.6	-0.8	0.8	-0.5
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.4	0.4	-0.7
Cocaine response before conditioning	0.3	0.3	0.5	0.7	-0.7	-0.2
Saline control response	0.4	0.5	1.2	0.4	-0.4	-1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	-0.3	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.1	-0.1
Condit. Reinf. active responses	0.3	0.4	0.8	0.4	-0.4	0.9
Condit. Reinf. inactive responses	0.7	0.8	2.4	0.1	-0.1	1.6
Condit. Reinf. lever presses	0.2	0.3	0.3	0.5	-0.5	0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.0	0.7	-0.7	1.0
Pavlov. Cond. lever latency	0.5	0.7	0.7	-0.9	0.9	-0.8
Pavlov. Cond. magazine entry latency	0.8	0.9	1.0	1.0	-1.0	-0.7
Pavlov. Cond. change in total contacts	2.8	3.9	5.8	2.4	-2.4	-0.5
Pavlov. Cond. index score	1.4	1.8	2.7	1.6	-1.6	-0.3
Pavlov. Cond. latency score	1.1	1.4	2.0	1.4	-1.4	-0.2
Pavlov. Cond. lever contacts	0.5	0.7	0.9	0.9	-0.9	0.7
Pavlov. Cond. magazine entry number	1.4	1.7	2.5	-1.6	1.6	0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.3	-0.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	2.6	1.6	-1.6	-0.6
Pavlov. Cond. response bias	0.8	1.1	1.6	1.3	-1.3	0.1
Conditioned reinforcement - actives	0.7	0.7	2.0	-0.1	0.1	-1.4
Conditioned reinforcement - inactives	0.7	0.8	1.0	-0.8	0.8	-1.0
Conditioned locomotion	1.1	1.3	3.4	0.6	-0.6	-1.8
Intermittent access intake day 1-15 change	0.9	0.9	2.3	-0.4	0.4	-1.5
Intermittent access intake escalation	1.1	1.1	2.8	-0.6	0.6	-1.7
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.4	0.4	-0.7
Intermitt. access day 1 inactive lever presses	5.8	6.3	9.0	-3.0	3.0	1.0
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.4	0.1	-0.1	1.2
Intermitt. access escalation Index	0.2	0.2	0.4	-0.1	0.1	0.7
Intermittent access day 1 total infusions	2.4	2.7	2.8	1.7	-1.7	-1.5
Intermittent access day 15 total infusions	2.6	3.0	5.2	1.4	-1.4	-2.3
Intermittent access terminal intake (last 3 days)	3.4	3.7	3.8	1.9	-1.9	-2.0
Intermittent access total infusions	2.8	3.0	3.6	1.7	-1.7	-1.9
Intermittent access day 1 locomotion	0.8	0.8	1.3	0.7	-0.7	-1.2
Intermittent access day 15 total locomotion	2.2	2.4	6.2	0.7	-0.7	-2.5
Intermittent access total locomotion	1.3	1.5	3.4	0.8	-0.8	-1.8
Intermittent access standard deviation	1.8	1.9	5.6	0.3	-0.3	-2.4
Cocaine induced anxiety	1.2	1.3	3.9	0.3	-0.3	2.0
Post-drug Anxiety	0.6	0.7	2.0	0.2	-0.2	1.4
Baseline Anxiety	0.5	0.5	1.5	-0.2	0.2	-1.2
Lifetime Intake	3.2	3.6	4.3	2.1	-2.1	-1.4
Incentive Sensitization - Responses	1.6	1.6	4.5	0.4	-0.4	-2.1
Incentive Sensitization - Breakpoint	1.5	1.5	4.1	0.4	-0.4	-2.0
Progressive ratio test 1 active lever presses	4.1	4.2	7.6	1.6	-1.6	-2.8
Progressive ratio test 1 breakpoint	4.1	4.2	6.9	1.7	-1.7	-2.6
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.2	0.2	-0.4
Progressive ratio test 2 active lever presses	2.4	2.5	4.5	1.2	-1.2	-2.1
Progressive ratio test 2 breakpoint	2.6	2.9	5.7	1.2	-1.2	-2.4
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.7	0.1	-0.1	-0.8
Total sessions with >9 infusions	2.4	2.6	3.5	1.9	-1.9	-1.0
Short access day 1 total inactive lever presses	1.2	1.3	2.0	-1.4	1.4	-0.0
Short access day 10 total inactive lever presses	0.9	1.0	2.7	-0.5	0.5	1.6
Short access day 1 total infusions	2.1	2.2	2.9	1.7	-1.7	-0.9
Short access day 10 total infusions	3.3	3.6	4.2	2.0	-2.0	-1.6
Short access total infusions	3.9	4.3	5.6	2.4	-2.4	-1.3
Short access day 1 locomotion	1.7	1.8	2.5	1.2	-1.2	-1.6
Short access day 10 total locomotion	1.5	1.7	2.4	-1.6	1.6	-0.3
Short access total locomotion	1.0	1.0	2.9	-0.3	0.3	-1.7
Compulsive drug intake	0.6	0.6	1.3	0.4	-0.4	1.2
One hour access (0.3 mA shock)	3.3	3.9	4.3	1.9	-1.9	-2.1
One hour access (shock baseline)	2.7	3.1	6.2	1.3	-1.3	-2.5
Number of responses in last shaping day	0.5	0.5	1.2	0.4	-0.4	-1.1
Context. condit. distance diff. score	1.0	1.2	1.8	1.4	-1.4	-0.3
Locomotion velocity, session 1	0.2	0.3	0.7	-0.2	0.2	0.8
Locomotion distance, session 1	0.1	0.1	0.1	0.4	-0.4	0.2
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	0.1	0.2
Locomotion distance, session 2	0.2	0.2	0.2	0.5	-0.5	-0.4
Locomotion velocity, session 3	1.0	1.2	1.8	1.3	-1.3	0.4
Locomotion distance, session 3	1.2	1.3	2.0	1.4	-1.4	-0.1
Stereotopy head waving bouts, day 3	1.4	1.7	2.4	-1.5	1.5	0.5
Stereotopy head waving duration, day 3	0.6	0.7	1.0	-1.0	1.0	0.3
Locomotion velocity, session 7	1.9	2.1	3.1	1.8	-1.8	0.3
Locomotion distance, session 7	0.6	0.8	1.1	1.1	-1.1	0.2
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	0.2	0.0
Stereotopy head waving duration, day 7	0.2	0.2	0.3	-0.5	0.5	0.2
Locomotion velocity, session 8	0.9	1.1	1.6	1.3	-1.3	-0.5
Locomotion distance, session 8	3.7	5.6	7.7	2.8	-2.8	-1.1
Degree of sensitization distance	0.2	0.2	0.3	-0.5	0.5	0.3
Degree of sensitization stereotypy	0.2	0.3	0.3	-0.5	0.5	0.6
Condit. Reinf. active minus inactive responses	0.5	0.6	1.5	-0.3	0.3	1.2
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.4	-1.0	1.0	1.2
Condit. Reinf. active responses	1.3	1.6	1.8	-1.2	1.2	1.4
Condit. Reinf. inactive responses	1.2	1.4	1.6	-1.3	1.3	0.9
Incentive salience index mean	0.0	0.1	0.2	0.1	-0.1	0.4
Condit. Reinf. lever presses	0.2	0.3	0.4	0.7	-0.7	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.3	-0.3	0.6
Time in novel zone, hab. session 1	1.0	0.9	1.2	-1.1	1.1	0.7
Total zone transitions, hab. session 1	2.9	4.1	5.3	2.3	-2.3	-1.3
Total locomotion distance, hab. session 1	3.5	5.1	6.9	2.6	-2.6	-1.2
Locomotion velocity, hab. session 1	4.9	7.1	9.2	3.0	-3.0	-1.7
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	-0.0	0.2
Time in novel zone, hab. session 2	0.4	0.4	0.8	-0.4	0.4	0.9
Total zone transitions, hab. session 2	0.6	0.8	1.1	1.1	-1.1	0.1
Total locomotion distance, hab. session 2	0.4	0.6	0.9	0.9	-0.9	-0.0
Locomotion velocity, hab. session 2	0.7	0.9	1.4	1.2	-1.2	-0.1
Novel to familiar place preference ratio	0.5	0.5	0.7	0.8	-0.8	-0.4
Novelty place preference	0.3	0.3	0.4	0.6	-0.6	-0.2
Time in novel zone, NPP test	0.3	0.3	0.4	0.7	-0.7	-0.2
Total zone transitions, NPP test	0.9	1.3	1.9	1.4	-1.4	-0.4
Total locomotion distance, NPP test	1.0	1.4	1.9	1.4	-1.4	-0.7
Locomotion velocity, NPP test	0.7	1.0	1.3	1.2	-1.2	-0.6
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.7	-0.7	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.1	-0.1	0.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.7	0.7	-0.0
Pavlov. Cond. index score	0.1	0.1	0.1	-0.2	0.2	0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.3	0.3	0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.5	0.0	-0.0	-0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.2	0.2	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	0.1	-0.1	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.1	0.1	0.4
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	-0.1	0.0
Bone: apparent density	0.1	0.1	0.2	-0.4	0.4	-0.2
Bone surface	0.0	0.1	0.2	0.1	-0.1	-0.4
Bone volume	0.1	0.1	0.2	0.3	-0.3	-0.5
Bone: connectivity density	0.5	0.8	1.1	-1.1	1.1	-0.2
Bone: cortical apparent density	1.5	1.9	2.9	1.7	-1.7	-0.2
Bone: cortical area	0.7	1.1	1.6	0.9	-0.9	-1.2
Bone: cortical porosity	0.5	0.5	0.8	-0.9	0.9	-0.2
Bone: cortical porosity	0.2	0.2	0.3	-0.5	0.5	-0.2
Bone: cortical thickness	0.5	0.8	2.0	0.5	-0.5	-1.4
Bone: cortical thickness	0.6	0.7	1.0	-1.0	1.0	0.4
Bone: cortical tissue density	1.6	2.1	3.2	1.8	-1.8	-0.1
Bone: elastic displacement	2.3	2.6	2.7	-1.6	1.6	1.6
Bone: elastic work	1.2	1.6	1.9	-1.4	1.4	1.0
Bone: endosteal estimation	0.4	0.8	1.9	-0.5	0.5	1.4
Bone: endosteal perimeter	0.4	0.9	1.3	1.1	-1.1	-0.4
Bone: final force	0.0	0.0	0.0	-0.1	0.1	0.1
Bone: final moment	0.0	0.0	0.0	-0.2	0.2	-0.1
Bone: marrow area	0.3	0.7	1.9	-0.4	0.4	1.4
Bone: maximum diameter	0.8	1.4	1.7	1.3	-1.3	-0.8
Bone: maximum force	0.0	0.1	0.2	-0.2	0.2	0.4
Bone: maximum moment	0.0	0.1	0.1	-0.3	0.3	0.3
Bone: minimum diameter	2.5	4.7	5.8	2.4	-2.4	-1.5
Bone: periosteal estimation	0.1	0.3	0.4	0.7	-0.7	0.2
Bone: periosteal perimeter	0.4	0.6	0.9	0.9	-0.9	-0.4
Bone: post-yield work	0.1	0.1	0.2	-0.4	0.4	-0.1
Bone: stiffness	0.2	0.3	0.4	0.6	-0.6	-0.2
Bone: tissue strength	0.1	0.1	0.2	-0.2	0.2	-0.4
Bone: trabecular number	0.5	0.8	1.3	-1.1	1.1	0.1
Bone: trabecular spacing	0.2	0.3	0.4	0.6	-0.6	-0.1
Bone: trabecular thickness	0.2	0.2	0.3	0.4	-0.4	-0.5
Bone: trabecular tissue density	0.3	0.4	0.4	0.7	-0.7	0.5
Breakpoint value in progressive ratio session	0.9	1.1	2.2	-0.7	0.7	1.5
Distance traveled before self-admin	0.3	0.3	0.4	0.6	-0.6	-0.3
Distance traveled after self-admin	0.4	0.5	0.7	0.8	-0.8	0.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.2	-0.4
Delta time in open arm before/after self-admin	0.9	0.9	1.7	-0.7	0.7	1.3
Diff in mean of infusions in LGA sessions	1.9	2.1	2.6	-1.6	1.6	1.1
Extinction: sum of active levers before priming	0.5	0.5	0.5	-0.7	0.7	0.6
Active lever presses in extinction session 6	0.1	0.1	0.4	0.1	-0.1	0.6
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.1	0.1
Delta ambulatory time before/after self-admin	0.4	0.4	0.8	-0.5	0.5	0.9
Time in closed arm before self-admin	1.1	1.3	1.7	1.3	-1.3	-0.7
Time in closed arm after self-admin	0.5	0.5	0.7	0.9	-0.9	-0.2
Time in open arm before self-admin	0.1	0.1	0.1	-0.3	0.3	0.1
Time in open arm after self-admin	0.6	0.7	1.0	-0.7	0.7	1.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	-0.1	-0.3
Time to tail flick, vehicle, before self-admin	3.7	3.7	7.8	1.3	-1.3	-2.8
Time to tail flick, vehicle, after self-admin	2.9	3.1	3.5	-1.9	1.9	1.5
Time to tail flick, test, before self-admin	0.3	0.3	0.4	0.7	-0.7	0.0
Time to tail flick, test, after self-admin	0.6	0.6	0.9	1.0	-1.0	-0.2
Delta time to tail flick, vehicle, before/after SA	5.3	5.1	8.0	-1.9	1.9	2.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.3	-0.2
Ambulatory time before self-admin	0.2	0.2	0.3	0.3	-0.3	-0.5
Ambulatory time after self-admin	1.0	1.1	1.7	1.3	-1.3	0.2
Total heroin consumption	0.7	0.8	1.2	0.8	-0.8	1.1
Area under the delay curve	0.2	0.3	0.8	0.0	-0.0	0.9
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	-0.4	0.4	0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	-0.2	0.2	0.8
Delay disc. indifference point, 2s delay	0.8	0.9	1.4	1.2	-1.2	-0.1
Delay disc. indifference point, 24s delay	1.3	1.2	1.8	1.4	-1.4	0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.4	0.2
Delay disc. indifference point, 8s delay	0.7	0.8	1.6	-0.6	0.6	1.3
Delay discount exponential model param	0.2	0.2	0.5	-0.2	0.2	-0.7
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.3	0.3	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.1	0.2	-0.2	1.0
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.7	-0.3	0.3	1.3
Bouts of movement, locomotor time 1	0.6	0.7	1.1	-0.7	0.7	1.0
Total resting periods, locomotor time 1	0.6	0.7	1.0	-0.7	0.7	1.0
Rest time, locomotor task time 1	1.1	1.2	1.8	-1.0	1.0	1.3
Distance moved, locomotor task time 1	0.8	0.8	1.6	0.7	-0.7	-1.3
Vertical activity count, locomotor time 1	2.9	3.0	3.5	1.9	-1.9	-1.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	0.3	0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.3	0.5	-0.5	0.4
Total resting periods, locomotor time 2	0.4	0.4	0.6	0.6	-0.6	0.8
Rest time, locomotor task time 2	1.2	1.4	3.1	-0.8	0.8	1.8
Distance moved, locomotor task time 2	0.5	0.6	1.7	0.2	-0.2	-1.3
Vertical activity count, locomotor time 2	2.4	2.7	5.5	1.1	-1.1	-2.3
Weight adjusted by age	2.0	2.3	3.4	1.9	-1.9	-0.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.5	0.8	-0.9	0.9	0.1
Locomotion in novel chamber	0.8	1.0	1.5	1.2	-1.2	0.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	-0.4	0.4	-0.6
Progressive ratio	0.8	1.0	2.1	-0.6	0.6	1.4
Food seeking constrained by brief footshock	0.7	0.9	2.5	0.3	-0.3	-1.6
Seeking ratio, punishment vs. effort	0.8	1.0	2.6	0.4	-0.4	-1.6
Run reversals in cocaine runway, females	0.2	0.2	0.2	0.4	-0.4	-0.5
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.1	-0.1	-0.0
Latency to leave start box in cocaine runway	1.3	1.4	2.0	1.4	-1.4	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	0.5	-0.5	0.4
Latency to leave start box in cocaine runway, M	3.2	3.1	3.2	1.7	-1.7	-1.8
Cd content in liver	0.1	0.1	0.1	0.3	-0.3	0.1
Co content in liver	2.1	2.4	3.4	1.4	-1.4	-1.9
Cu content in liver	0.3	0.4	1.1	0.2	-0.2	-1.0
Fe content in liver	0.2	0.2	0.3	0.5	-0.5	0.1
K content in liver	0.8	0.8	0.9	-0.9	0.9	-0.9
Mg content in liver	0.1	0.1	0.2	-0.5	0.5	-0.0
Mn content in liver	0.0	0.1	0.1	-0.2	0.2	-0.3
Na content in liver	0.0	0.0	0.0	0.0	-0.0	-0.2
Rb content in liver	1.4	1.7	2.5	-1.6	1.6	0.1
Se content in liver	0.6	0.8	1.0	1.0	-1.0	0.6
Sr content in liver	0.2	0.1	0.3	-0.3	0.3	-0.5
Zn content in liver	0.4	0.5	0.5	0.7	-0.7	-0.6