Hub : Genes

Ccnt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	ENSRNOG00000053054	0.05	0.03	6.6e-06	0.05	0.06	0.06	0.05	9.4e-06	6.4e-06	3.8e-06	8.6e-06
2	NAcc	mRNA stability	ENSRNOG00000053054	0.04	0.03	5.6e-03	0	0.01	0	0	2.9e-01	3.1e-02	1.2e-01	1.6e-01
3	PL	gene expression	ENSRNOG00000053054	0.08	0.06	1.7e-07	0.08	0.09	0.07	0.08	9.0e-07	4.5e-07	3.7e-06	1.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	4.7	15.3	16.5	-3.7	-4.1	4.0
BMI without tail	0.0	0.1	0.1	-0.2	-0.3	0.2
Body weight	6.7	28.3	29.9	-5.1	-5.5	5.4
Epididymis fat weight	0.2	0.4	0.6	-0.4	-0.8	0.6
Glucose	0.1	0.2	0.3	-0.5	-0.4	0.4
Heart weight	0.0	0.0	0.0	-0.1	-0.2	0.2
Left kidney weight	0.4	1.1	1.4	-0.8	-1.2	1.2
Right kidney weight	2.8	8.1	8.3	-2.8	-2.9	2.9
Tail length	0.1	0.2	0.2	0.3	0.4	-0.5
Length with tail	2.0	7.2	7.5	-2.6	-2.7	2.7
Length without tail	7.6	16.7	17.6	-3.9	-4.2	4.2
Liver weight, left	2.1	3.4	3.4	-1.8	-1.9	1.8
Liver weight, right	1.7	2.8	3.0	-1.6	-1.7	1.7
Parametrial fat weight	1.9	3.8	4.0	2.0	1.9	-1.9
Retroperitoneal fat weight	0.3	0.9	1.2	1.1	0.8	-0.9
Intraocular pressure	7.7	10.9	11.4	3.2	3.4	-3.3
Extensor digitorum longus weight	4.7	19.0	19.8	-4.4	-4.3	4.3
Soleus weight	0.6	1.7	1.9	-1.4	-1.3	1.3
Tibialis anterior weight	1.4	4.9	5.7	-2.4	-2.1	2.1
Tibia length	7.8	21.8	22.0	-4.7	-4.7	4.7
Number of licking bursts	0.1	0.2	0.2	0.2	0.5	-0.5
Food consumed during 24 hour testing period	1.7	2.1	2.2	-1.4	-1.5	1.5
Times rat made contact with spout	0.0	0.0	0.0	0.2	0.0	-0.1
Mean time between licks in bursts	0.2	0.2	0.3	0.5	0.5	-0.5
Mean num. licks in bursts	0.0	0.0	0.1	0.4	-0.1	0.0
Std. dev. time between licks in bursts	0.9	1.0	1.2	0.9	1.1	-1.1
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.1	0.0
Indifference point 0 sec	2.1	3.4	3.5	1.9	1.8	-1.9
Indifference point AUC	0.2	0.2	0.3	0.4	0.5	-0.5
Indifference point function ln k	3.5	5.0	5.1	-2.2	-2.3	2.2
Indifference point function log k	3.5	5.0	5.1	-2.2	-2.3	2.2
Delay discounting total patch changes 0 sec	2.1	3.3	3.4	1.8	1.8	-1.8
Delay discounting total patch changes 12 sec	1.7	2.2	2.5	1.3	1.6	-1.5
Delay discounting total patch changes 18 sec	4.2	5.6	5.9	2.3	2.4	-2.4
Delay discounting total patch changes 24 sec	1.7	2.2	2.4	1.3	1.5	-1.6
Delay discounting total patch changes 6 sec	2.3	3.6	3.7	1.8	1.9	-1.9
Delay discounting time to switch 0 sec	2.4	3.7	4.1	1.8	2.0	-1.9
Delay discounting water rate 0 sec	3.3	5.2	5.5	-2.2	-2.3	2.3
Delay discounting water rate 12 sec	3.7	5.6	5.8	-2.3	-2.4	2.4
Delay discounting water rate 18 sec	0.4	0.5	0.5	-0.7	-0.7	0.7
Delay discounting water rate 24 sec	3.2	4.4	5.1	-2.3	-2.0	2.1
Delay discounting water rate 6 sec	3.9	5.7	5.8	-2.4	-2.4	2.4
Locomotor activity	0.8	1.3	1.4	1.0	1.2	-1.2
Locomotor testing distance	2.6	4.4	4.6	2.0	2.1	-2.1
Locomotor testing rearing	2.1	3.3	3.7	1.6	1.9	-1.9
Light reinforcement 1	2.7	4.9	5.5	1.9	2.3	-2.3
Light reinforcement 2	0.7	0.9	1.0	0.8	1.0	-1.0
Reaction time number correct	1.0	1.5	1.6	-1.3	-1.1	1.2
Reaction time mean minus median	8.4	11.0	11.9	3.4	3.2	-3.2
Reaction time mean minus median AUC	6.4	8.1	8.9	3.0	2.8	-2.8
Reaction time num false alarms	1.9	2.6	2.7	1.6	1.6	-1.6
Reaction time num false alarms AUC	2.8	3.9	4.1	2.0	2.0	-1.9
Reaction time trials correct on left	1.0	1.5	1.6	-1.3	-1.1	1.2
Reaction time trials on left	0.7	1.1	1.2	-1.1	-1.0	1.1
Reaction time mean	0.5	0.7	0.8	0.9	0.7	-0.8
Reaction time mean AUC	0.2	0.3	0.5	0.7	0.5	-0.5
Median of all reaction times	0.0	0.1	0.1	-0.2	-0.3	0.3
Reaction time omissions	10.1	13.7	13.9	3.7	3.7	-3.7
Reaction time false alarm rate	2.7	3.8	4.1	2.0	1.9	-1.9
Reaction time premature initiation rate	5.5	7.4	8.0	2.5	2.8	-2.8
Reaction time premature initiations	2.7	3.9	4.4	1.8	2.1	-2.0
Std. dev. reaction times	6.2	8.5	9.3	3.0	2.8	-2.9
Reaction time trials completed	0.7	1.1	1.2	-1.1	-1.0	1.1
Reaction time trials AUC	1.3	1.9	2.0	-1.4	-1.3	1.4
Social response proportion	0.1	0.1	0.1	0.2	0.3	-0.3
Social responses	7.5	9.8	10.7	2.9	3.3	-3.2
Social time	0.0	0.0	0.0	0.2	0.1	-0.0
Conditioned locomotion	0.0	0.0	0.1	-0.3	-0.1	0.1
Cocaine response after cond. corrected	0.0	0.0	0.1	0.3	-0.1	0.1
Cocaine response after cond. not corrected	0.7	0.8	1.1	1.1	0.7	-0.7
Cocaine response before conditioning	4.1	5.0	5.6	2.1	2.4	-2.3
Saline control response	0.0	0.0	0.1	-0.2	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	0.2	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	0.6	0.6	-0.6
Condit. Reinf. active responses	0.3	0.4	0.4	0.6	0.6	-0.6
Condit. Reinf. inactive responses	0.7	0.9	1.0	0.8	1.0	-1.0
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.1	-0.1
Condit. Reinf. lever reinforcers received	0.6	0.9	0.9	0.9	1.0	-1.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.0	-0.0	0.0
Pavlov. Cond. magazine entry latency	0.9	1.0	1.1	-1.0	-1.0	1.0
Pavlov. Cond. change in total contacts	1.8	2.4	2.5	-1.5	-1.6	1.6
Pavlov. Cond. index score	0.5	0.7	0.7	-0.8	-0.8	0.8
Pavlov. Cond. latency score	0.6	0.8	0.8	-0.9	-0.9	0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	2.3	2.8	2.9	1.7	1.6	-1.7
Pavlov. Cond. intertrial magazine entries	4.7	6.1	6.1	2.5	2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.3	-1.1	-1.1	1.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.0	-0.0
Conditioned reinforcement - actives	1.5	1.4	1.5	1.1	1.2	-1.2
Conditioned reinforcement - inactives	1.5	1.8	1.8	1.3	1.3	-1.3
Conditioned locomotion	0.3	0.4	0.5	0.5	0.7	-0.7
Intermittent access intake day 1-15 change	1.1	1.1	1.3	1.1	1.0	-1.0
Intermittent access intake escalation	0.7	0.7	0.9	1.0	0.8	-0.8
Intermittent access intake escalation 2	1.2	1.2	1.3	1.2	1.0	-1.0
Intermitt. access day 1 inactive lever presses	3.6	3.9	4.3	1.8	2.1	-2.0
Intermitt. access day 15 inactive lever presses	1.3	1.5	1.5	1.2	1.2	-1.2
Intermitt. access escalation Index	0.2	0.2	0.3	0.4	0.5	-0.5
Intermittent access day 1 total infusions	1.1	1.3	1.3	1.1	1.1	-1.1
Intermittent access day 15 total infusions	2.2	2.5	2.5	1.6	1.6	-1.6
Intermittent access terminal intake (last 3 days)	2.5	2.8	2.9	1.7	1.6	-1.7
Intermittent access total infusions	2.2	2.5	2.5	1.6	1.6	-1.6
Intermittent access day 1 locomotion	1.0	1.0	1.1	0.9	1.1	-1.1
Intermittent access day 15 total locomotion	1.3	1.4	1.6	1.0	1.2	-1.3
Intermittent access total locomotion	3.2	3.6	4.0	1.7	2.0	-2.0
Intermittent access standard deviation	0.4	0.4	0.5	0.7	0.7	-0.6
Cocaine induced anxiety	1.2	1.4	1.6	-1.3	-1.1	1.1
Post-drug Anxiety	4.9	5.4	5.7	-2.4	-2.3	2.3
Baseline Anxiety	1.1	1.2	1.3	-1.0	-1.1	1.1
Lifetime Intake	1.8	2.1	2.1	1.4	1.4	-1.5
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.3	-0.2	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	-0.1	0.1
Progressive ratio test 1 active lever presses	3.8	4.0	4.3	1.9	2.0	-2.1
Progressive ratio test 1 breakpoint	3.4	3.5	3.8	1.8	1.9	-2.0
Progressive ratio test 1 inactive lever presses	3.5	3.7	4.0	1.9	1.9	-2.0
Progressive ratio test 2 active lever presses	2.0	2.1	2.3	1.3	1.5	-1.5
Progressive ratio test 2 breakpoint	2.6	2.9	3.1	1.6	1.7	-1.8
Progressive ratio test 2 inactive lever presses	2.6	3.0	3.2	1.6	1.8	-1.8
Total sessions with >9 infusions	0.3	0.4	0.4	0.6	0.6	-0.7
Short access day 1 total inactive lever presses	1.1	1.2	1.2	1.1	1.1	-1.1
Short access day 10 total inactive lever presses	0.5	0.5	0.6	0.5	0.8	-0.7
Short access day 1 total infusions	0.0	0.0	0.0	-0.0	-0.1	0.0
Short access day 10 total infusions	0.5	0.6	0.6	0.8	0.7	-0.7
Short access total infusions	0.2	0.2	0.2	0.4	0.4	-0.4
Short access day 1 locomotion	0.0	0.0	0.0	0.1	0.1	-0.2
Short access day 10 total locomotion	0.2	0.2	0.3	0.3	0.5	-0.6
Short access total locomotion	0.3	0.3	0.4	0.4	0.6	-0.6
Compulsive drug intake	0.8	0.8	0.9	-0.8	-0.9	0.9
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.3	0.4	-0.4
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.1	-0.2
Number of responses in last shaping day	0.1	0.1	0.2	-0.5	-0.4	0.3
Context. condit. distance diff. score	0.3	0.4	0.4	-0.6	-0.6	0.6
Locomotion velocity, session 1	1.2	1.2	1.3	1.1	1.1	-1.1
Locomotion distance, session 1	3.1	4.0	4.6	2.1	1.9	-2.0
Locomotion velocity, session 2	0.3	0.3	0.4	0.6	0.6	-0.5
Locomotion distance, session 2	2.5	3.5	4.0	2.0	1.8	-1.8
Locomotion velocity, session 3	3.8	4.4	4.6	2.1	2.1	-2.1
Locomotion distance, session 3	5.2	5.6	5.8	2.4	2.3	-2.4
Stereotopy head waving bouts, day 3	1.2	1.4	1.7	-1.3	-1.1	1.2
Stereotopy head waving duration, day 3	0.4	0.5	0.6	-0.8	-0.7	0.7
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	0.3	-0.4
Locomotion distance, session 7	1.3	1.7	1.8	1.3	1.3	-1.4
Stereotopy head waving bouts, day 7	1.1	1.2	1.7	-1.3	-1.0	1.0
Stereotopy head waving duration, day 7	1.3	1.6	2.0	-1.4	-1.1	1.2
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion distance, session 8	1.3	1.9	2.2	1.5	1.3	-1.3
Degree of sensitization distance	0.6	0.6	0.7	-0.8	-0.8	0.8
Degree of sensitization stereotypy	0.3	0.3	0.5	-0.7	-0.4	0.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.3	-0.5	0.5
Condit. Reinf. active responses	0.5	0.6	0.7	0.8	0.8	-0.7
Condit. Reinf. inactive responses	2.7	3.2	3.3	1.7	1.8	-1.8
Incentive salience index mean	0.1	0.1	0.1	-0.2	-0.3	0.3
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.6	-0.7	0.7
Time in familiar zone, hab. session 1	0.4	0.3	0.5	0.7	0.5	-0.5
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.7	-0.5	0.5
Total zone transitions, hab. session 1	0.3	0.5	0.5	0.7	0.7	-0.7
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	0.0	-0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.0	-0.1	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.3	-0.5	0.5
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.2	0.6	-0.5
Total zone transitions, hab. session 2	0.3	0.3	0.5	0.7	0.5	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.5	0.3	-0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.3	0.1	-0.1
Novel to familiar place preference ratio	1.8	1.9	2.3	-1.5	-1.3	1.3
Novelty place preference	1.3	1.3	1.7	-1.3	-1.1	1.1
Time in novel zone, NPP test	1.0	1.0	1.4	-1.2	-0.9	0.9
Total zone transitions, NPP test	1.1	1.5	1.8	1.4	1.2	-1.2
Total locomotion distance, NPP test	1.8	2.5	2.8	1.7	1.5	-1.5
Locomotion velocity, NPP test	0.9	1.3	1.5	1.2	1.1	-1.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	-0.3	0.4
Pavlov. Cond. index score	0.2	0.2	0.2	-0.5	-0.5	0.4
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.4	-0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	0.8	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.6	-0.8	-0.8	0.8
Pavlov. Cond. response bias	0.0	0.0	0.0	0.2	0.1	-0.1
Bone: apparent density	10.2	16.9	18.0	-3.9	-4.2	4.2
Bone surface	12.0	21.1	21.9	-4.4	-4.7	4.7
Bone volume	9.0	15.2	15.9	-3.7	-4.0	4.0
Bone: connectivity density	7.2	11.3	12.0	-3.1	-3.5	3.5
Bone: cortical apparent density	0.3	0.4	0.5	0.6	0.7	-0.7
Bone: cortical area	10.6	16.1	16.3	-4.0	-4.0	4.0
Bone: cortical porosity	1.3	1.4	1.5	1.1	1.2	-1.2
Bone: cortical porosity	1.9	2.0	2.1	1.3	1.5	-1.4
Bone: cortical thickness	4.5	7.4	7.6	-2.7	-2.8	2.7
Bone: cortical thickness	0.3	0.3	0.4	-0.5	-0.6	0.6
Bone: cortical tissue density	0.5	0.6	0.7	0.7	0.8	-0.8
Bone: elastic displacement	5.0	5.6	5.8	2.3	2.4	-2.4
Bone: elastic work	0.0	0.0	0.0	0.2	0.2	-0.2
Bone: endosteal estimation	7.2	15.5	15.8	-4.0	-3.9	3.9
Bone: endosteal perimeter	7.1	14.6	15.0	-3.9	-3.8	3.8
Bone: final force	10.1	16.6	17.3	-3.9	-4.2	4.1
Bone: final moment	10.2	16.8	17.7	-3.9	-4.2	4.2
Bone: marrow area	7.1	15.2	15.5	-3.9	-3.9	3.9
Bone: maximum diameter	4.4	8.1	8.5	-2.9	-2.8	2.8
Bone: maximum force	13.5	23.4	24.2	-4.7	-4.9	4.9
Bone: maximum moment	13.5	23.5	24.4	-4.7	-4.9	4.9
Bone: minimum diameter	9.2	17.0	17.5	-4.2	-4.1	4.1
Bone: periosteal estimation	12.3	25.1	25.2	-5.0	-5.0	5.0
Bone: periosteal perimeter	10.8	17.9	18.2	-4.2	-4.3	4.3
Bone: post-yield work	7.3	9.9	10.2	-3.2	-3.1	3.1
Bone: stiffness	16.4	25.9	26.7	-5.0	-5.2	5.1
Bone: tissue strength	0.7	0.6	0.7	-0.8	-0.8	0.8
Bone: trabecular number	5.7	8.9	9.8	-2.6	-3.1	3.1
Bone: trabecular spacing	2.0	2.5	3.0	1.3	1.7	-1.7
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.2	-0.3
Bone: trabecular tissue density	0.1	0.1	0.1	0.2	0.4	-0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.2	-0.5	-0.4	0.4
Distance traveled before self-admin	1.1	1.2	1.3	1.0	1.1	-1.1
Distance traveled after self-admin	0.2	0.2	0.2	0.5	0.4	-0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.2	-0.5	0.5
Delta time in open arm before/after self-admin	4.1	3.9	4.2	1.8	2.0	-2.0
Diff in mean of infusions in LGA sessions	1.4	1.6	1.7	-1.2	-1.3	1.3
Extinction: sum of active levers before priming	0.3	0.3	0.4	-0.6	-0.6	0.6
Active lever presses in extinction session 6	0.5	0.5	0.5	-0.7	-0.7	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.1	-0.1	-0.4	0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.0	-0.2	0.2
Time in closed arm before self-admin	1.4	1.6	2.2	-1.5	-1.1	1.2
Time in closed arm after self-admin	0.6	0.6	0.6	-0.7	-0.8	0.8
Time in open arm before self-admin	0.7	0.7	0.9	-0.7	-1.0	0.9
Time in open arm after self-admin	0.2	0.3	0.3	0.5	0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	0.3	-0.3
Time to tail flick, vehicle, before self-admin	1.2	1.2	1.3	1.0	1.1	-1.1
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.5	-0.4	0.4
Time to tail flick, test, before self-admin	0.5	0.5	0.7	0.8	0.6	-0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.2	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.5	-0.7	-0.7	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.5	-0.5	0.4
Ambulatory time before self-admin	4.0	4.1	4.4	1.9	2.1	-2.1
Ambulatory time after self-admin	1.6	1.8	1.9	1.2	1.4	-1.4
Total heroin consumption	1.9	2.3	2.6	-1.6	-1.5	1.4
Area under the delay curve	1.2	1.2	1.5	-1.0	-1.2	1.2
Delay disc. indifference point, 0s delay	1.2	1.4	1.4	-1.1	-1.2	1.2
Delay disc. indifference point, 16s delay	1.3	1.3	1.3	-1.1	-1.2	1.1
Delay disc. indifference point, 2s delay	1.2	1.4	1.4	-1.1	-1.2	1.2
Delay disc. indifference point, 24s delay	1.5	1.4	1.5	-1.2	-1.2	1.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.3	-0.6	0.6
Delay disc. indifference point, 8s delay	3.1	3.2	3.6	-1.6	-1.9	1.8
Delay discount exponential model param	1.0	1.1	1.3	0.9	1.1	-1.1
Delay discount hyperbolic model param	0.9	1.0	1.2	0.8	1.1	-1.1
Fecal boli incidents, locomotor time 1	1.4	1.6	2.3	1.5	1.0	-1.2
Change in fecal boli incidents, locomotor task	1.2	1.1	1.3	-1.1	-1.0	1.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	-0.3	-0.6	0.5
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.1	-0.3	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.5	0.2	-0.3
Rest time, locomotor task time 1	0.2	0.2	0.3	0.5	0.3	-0.4
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.0	0.2	-0.1
Vertical activity count, locomotor time 1	1.3	1.4	1.6	-1.0	-1.2	1.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.4	0.6	0.6	-0.7
Bouts of movement, locomotor time 2	2.5	2.6	2.8	-1.6	-1.7	1.6
Total resting periods, locomotor time 2	2.8	3.0	3.1	-1.7	-1.8	1.7
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.4	0.3
Distance moved, locomotor task time 2	0.2	0.2	0.3	0.4	0.5	-0.5
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.2	-0.2	0.2
Weight adjusted by age	2.6	2.9	3.5	-1.9	-1.6	1.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.6	-0.4	-0.7	0.7
Locomotion in novel chamber	0.6	0.8	0.8	-0.9	-0.8	0.9
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.2	-0.3	0.2
Progressive ratio	0.0	0.0	0.1	0.2	0.1	-0.2
Food seeking constrained by brief footshock	0.1	0.2	0.2	0.4	0.4	-0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	-0.0	-0.0
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.1	0.2	-0.2
Run reversals in cocaine runway, males	1.5	1.4	1.5	1.1	1.2	-1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	0.1	-0.1
Latency to leave start box in cocaine runway, F	1.9	2.1	2.2	1.4	1.5	-1.5
Latency to leave start box in cocaine runway, M	2.0	2.0	2.1	-1.3	-1.4	1.5
Cd content in liver	0.4	0.4	0.4	0.6	0.6	-0.7
Co content in liver	0.1	0.1	0.1	0.2	0.3	-0.3
Cu content in liver	1.1	1.3	1.4	-1.2	-1.1	1.1
Fe content in liver	0.1	0.1	0.1	0.3	0.4	-0.4
K content in liver	0.5	0.5	0.6	-0.6	-0.7	0.7
Mg content in liver	0.0	0.0	0.0	0.0	-0.1	0.1
Mn content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Na content in liver	0.0	0.0	0.0	0.0	0.1	-0.1
Rb content in liver	0.1	0.2	0.2	0.3	0.4	-0.4
Se content in liver	0.4	0.5	0.5	0.7	0.7	-0.7
Sr content in liver	0.7	0.7	0.7	-0.9	-0.8	0.8
Zn content in liver	1.2	1.3	1.5	1.0	1.2	-1.2