Tcf7l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	ENSRNOG00000049232	0.14	0.11	7.3e-03	0.04	0.06	0.06	0.06	3.9e-02	2.0e-02	1.8e-02	1.2e-02
2	LHb	mRNA stability	ENSRNOG00000049232	0.15	0.11	4.8e-03	0.07	0.05	0.08	0.07	1.2e-02	2.0e-02	6.4e-03	1.0e-02
3	Liver	intron excision ratio	chr1:254787414:254860496	0.03	0.03	3.4e-03	0	0	-0	0	2.2e-01	3.5e-01	4.0e-01	2.1e-01
4	PL	gene expression	ENSRNOG00000049232	0.04	0.03	1.7e-03	0.02	0.02	0.03	0.02	1.8e-02	6.5e-03	4.8e-03	1.6e-02
5	PL	intron excision ratio	chr1:254787414:254860496	0.04	0.03	5.4e-03	0.02	0.02	0.01	0.02	1.7e-02	1.3e-02	2.6e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	10.7	34.8	39.8	6.2	5.4	-6.1	-6.3	-5.5
BMI without tail	4.5	9.4	10.9	3.3	2.7	-3.3	-3.3	-2.7
Body weight	12.5	53.0	60.4	7.8	6.8	-7.4	-7.7	-6.7
Epididymis fat weight	15.9	37.1	46.7	6.8	5.1	-6.8	-6.4	-5.0
Glucose	4.5	6.9	8.2	2.5	2.6	-2.3	-2.9	-2.8
Heart weight	2.7	3.8	4.9	1.8	1.8	-2.1	-2.2	-1.9
Left kidney weight	5.9	16.8	23.6	3.6	4.4	-3.0	-4.4	-4.9
Right kidney weight	6.7	19.0	24.2	4.0	4.4	-3.6	-4.8	-4.9
Tail length	0.2	0.7	1.3	1.0	0.5	-1.1	-0.8	-0.4
Length with tail	2.9	10.6	12.1	3.5	3.0	-3.3	-3.4	-3.0
Length without tail	6.9	15.2	16.8	4.0	3.8	-3.8	-4.1	-3.8
Liver weight, left	3.0	4.9	7.8	2.7	1.4	-2.8	-2.3	-1.5
Liver weight, right	9.1	15.0	17.3	4.2	3.6	-4.0	-4.1	-3.5
Parametrial fat weight	7.3	14.4	21.5	4.5	3.0	-4.6	-3.7	-2.6
Retroperitoneal fat weight	15.0	49.5	57.3	7.6	6.4	-7.4	-7.4	-6.2
Intraocular pressure	3.3	4.6	8.7	2.6	1.6	-3.0	-2.0	-1.0
Extensor digitorum longus weight	0.5	2.0	3.1	1.8	1.2	-1.7	-1.3	-0.9
Soleus weight	4.9	14.2	16.4	3.8	4.1	-3.0	-3.8	-4.0
Tibialis anterior weight	0.1	0.3	0.8	0.1	-0.6	-0.0	0.5	0.9
Tibia length	2.2	6.1	8.3	2.0	2.4	-2.0	-2.9	-2.9
Number of licking bursts	0.5	0.5	1.7	0.7	0.2	-1.3	-0.7	0.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.0	0.5	-0.2	-0.4	-0.5
Times rat made contact with spout	1.4	1.6	2.1	1.4	1.3	-1.2	-1.2	-1.1
Mean time between licks in bursts	0.1	0.1	0.2	0.2	-0.4	-0.4	0.1	0.5
Mean num. licks in bursts	0.6	0.7	1.6	0.6	1.1	0.2	-0.6	-1.3
Std. dev. time between licks in bursts	0.4	0.5	1.2	-0.2	-0.9	-0.4	0.5	1.1
Water consumed over 24 hours	1.1	1.2	2.1	0.8	1.3	-0.6	-1.2	-1.4
Indifference point 0 sec	3.4	5.4	7.2	2.7	2.0	-2.6	-2.4	-1.8
Indifference point AUC	0.4	0.5	0.8	0.8	-0.3	-0.9	0.2	0.9
Indifference point function ln k	0.2	0.2	0.4	-0.6	0.2	0.6	-0.2	-0.6
Indifference point function log k	0.2	0.2	0.4	-0.6	0.2	0.6	-0.2	-0.6
Delay discounting total patch changes 0 sec	3.1	5.0	7.1	2.7	1.9	-2.7	-2.2	-1.6
Delay discounting total patch changes 12 sec	0.7	0.9	2.1	1.4	0.4	-1.4	-0.6	-0.1
Delay discounting total patch changes 18 sec	1.9	2.5	5.6	2.2	0.7	-2.4	-1.1	-0.2
Delay discounting total patch changes 24 sec	0.9	1.2	2.8	1.6	-0.2	-1.7	-0.4	0.5
Delay discounting total patch changes 6 sec	3.9	5.9	9.5	3.0	2.0	-3.1	-2.3	-1.5
Delay discounting time to switch 0 sec	0.6	0.9	1.6	-1.1	-0.7	1.3	0.9	0.5
Delay discounting water rate 0 sec	0.7	1.1	1.4	1.1	0.8	-1.2	-1.1	-0.8
Delay discounting water rate 12 sec	0.9	1.4	2.3	1.4	1.0	-1.5	-1.2	-0.7
Delay discounting water rate 18 sec	1.2	1.6	2.3	1.0	1.2	-1.3	-1.5	-1.2
Delay discounting water rate 24 sec	3.1	4.2	5.5	2.0	1.7	-2.4	-2.3	-1.8
Delay discounting water rate 6 sec	0.8	1.2	1.8	0.6	1.2	-0.8	-1.3	-1.3
Locomotor activity	1.4	2.2	3.1	1.2	1.6	-1.1	-1.7	-1.8
Locomotor testing distance	2.1	3.4	5.6	1.3	2.2	-1.1	-2.0	-2.4
Locomotor testing rearing	1.2	2.0	2.8	1.1	1.6	-1.0	-1.5	-1.7
Light reinforcement 1	1.0	1.8	2.1	-1.5	-1.4	1.3	1.4	1.3
Light reinforcement 2	1.5	2.0	2.7	-1.6	-1.3	1.5	1.4	1.1
Reaction time number correct	1.1	1.6	2.8	1.5	1.0	-1.7	-1.2	-0.7
Reaction time mean minus median	0.2	0.2	0.5	0.4	0.3	-0.7	-0.5	-0.3
Reaction time mean minus median AUC	0.5	0.7	0.9	0.7	0.8	-0.7	-0.9	-1.0
Reaction time num false alarms	0.0	0.0	0.1	0.1	-0.3	-0.1	0.1	0.2
Reaction time num false alarms AUC	0.0	0.0	0.0	0.0	-0.2	0.1	0.1	0.0
Reaction time trials correct on left	1.1	1.6	2.8	1.5	1.0	-1.7	-1.2	-0.7
Reaction time trials on left	1.2	1.7	3.0	1.5	1.0	-1.7	-1.3	-0.7
Reaction time mean	0.0	0.1	0.2	-0.2	0.1	0.3	-0.1	-0.4
Reaction time mean AUC	0.2	0.2	0.4	-0.7	-0.3	0.6	0.3	0.0
Median of all reaction times	0.1	0.2	0.4	-0.4	0.1	0.6	-0.1	-0.5
Reaction time omissions	0.2	0.3	0.6	0.5	0.3	-0.8	-0.7	-0.5
Reaction time false alarm rate	0.4	0.6	0.7	-0.7	-0.8	0.8	0.8	0.6
Reaction time premature initiation rate	0.8	1.1	2.0	0.9	1.2	-0.2	-0.9	-1.4
Reaction time premature initiations	2.2	3.1	3.8	1.8	1.9	-1.3	-1.8	-1.9
Std. dev. reaction times	0.8	1.1	1.3	1.0	0.9	-1.1	-1.1	-1.0
Reaction time trials completed	1.2	1.7	3.0	1.5	1.0	-1.7	-1.3	-0.7
Reaction time trials AUC	1.3	1.8	3.2	1.6	1.0	-1.8	-1.3	-0.7
Social response proportion	4.0	4.4	6.4	1.8	2.2	-1.4	-2.3	-2.5
Social responses	3.9	5.1	7.2	2.7	1.9	-2.6	-2.3	-1.7
Social time	1.6	2.0	2.8	1.4	1.7	-1.0	-1.4	-1.6
Conditioned locomotion	0.0	0.0	0.1	-0.2	-0.1	0.3	0.2	0.1
Cocaine response after cond. corrected	1.0	1.1	2.1	-1.2	-0.6	1.5	1.1	0.6
Cocaine response after cond. not corrected	2.2	2.5	3.9	-1.7	-1.3	2.0	1.6	1.1
Cocaine response before conditioning	0.9	1.1	1.8	-0.9	-1.3	0.7	1.0	1.1
Saline control response	0.3	0.5	1.0	-0.8	-0.4	1.0	0.7	0.3
Condit. Reinf. active minus inactive responses	0.7	0.9	1.8	-0.4	-1.2	-1.0	0.2	1.3
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.7	-0.8	-1.3	-0.4	0.5	1.3
Condit. Reinf. active responses	0.6	0.8	2.7	0.4	-0.6	-1.6	-0.4	0.8
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.8	0.1	-1.0	-0.4	0.0
Condit. Reinf. lever presses	0.3	0.4	0.9	0.1	-0.8	-0.9	-0.1	0.7
Condit. Reinf. lever reinforcers received	0.5	0.7	2.0	0.2	-0.8	-1.4	-0.2	1.0
Pavlov. Cond. lever latency	0.6	0.8	1.6	-0.1	1.3	0.9	-0.3	-1.3
Pavlov. Cond. magazine entry latency	1.0	1.1	2.2	1.5	0.4	-1.4	-1.0	-0.6
Pavlov. Cond. change in total contacts	0.5	0.7	2.0	0.8	-0.4	-1.4	-0.3	0.6
Pavlov. Cond. index score	0.6	0.8	2.4	1.1	-0.2	-1.5	-0.7	0.1
Pavlov. Cond. latency score	0.6	0.8	2.2	1.1	-0.2	-1.5	-0.7	0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.9	0.5	-0.6	-1.0	-0.2	0.5
Pavlov. Cond. magazine entry number	0.8	1.0	1.9	-1.4	-0.4	1.4	0.9	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.2	0.3	-0.4	-0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.2	1.0	-0.1	-1.5	-0.7	0.0
Pavlov. Cond. response bias	0.4	0.6	1.8	0.9	-0.3	-1.4	-0.6	0.2
Conditioned reinforcement - actives	0.3	0.3	0.3	-0.5	-0.5	0.5	0.6	0.5
Conditioned reinforcement - inactives	0.3	0.4	0.7	0.9	0.3	-0.9	-0.6	-0.2
Conditioned locomotion	0.4	0.5	0.6	-0.7	-0.6	0.8	0.8	0.6
Intermittent access intake day 1-15 change	2.2	2.2	3.3	1.7	1.0	-1.8	-1.6	-1.1
Intermittent access intake escalation	4.1	4.0	5.0	2.1	1.7	-2.1	-2.2	-1.9
Intermittent access intake escalation 2	2.3	2.3	3.0	1.5	1.3	-1.5	-1.7	-1.5
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.7	1.6	0.7	-1.6	-1.2	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1	0.1
Intermitt. access escalation Index	0.2	0.2	0.4	0.3	0.5	-0.3	-0.5	-0.6
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.2	-0.5	-0.5	0.2	0.7
Intermittent access day 15 total infusions	1.2	1.3	2.7	1.4	0.6	-1.7	-1.1	-0.5
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.2	0.8	0.2	-1.1	-0.6	-0.1
Intermittent access total infusions	0.4	0.4	1.3	0.8	0.1	-1.1	-0.5	0.1
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.0
Intermittent access day 15 total locomotion	1.7	1.8	2.7	1.6	1.0	-1.6	-1.4	-0.9
Intermittent access total locomotion	0.1	0.2	0.3	0.3	0.4	-0.2	-0.5	-0.6
Intermittent access standard deviation	0.9	1.0	2.6	1.3	0.1	-1.6	-0.6	0.3
Cocaine induced anxiety	2.7	3.1	6.5	-2.3	-0.9	2.5	1.7	0.7
Post-drug Anxiety	0.2	0.2	0.6	-0.7	-0.0	0.8	0.4	-0.0
Baseline Anxiety	5.5	5.8	10.4	2.9	1.6	-3.2	-2.4	-1.4
Lifetime Intake	0.5	0.6	1.6	1.0	0.1	-1.3	-0.6	0.1
Incentive Sensitization - Responses	0.7	0.7	1.5	0.9	0.3	-1.2	-1.0	-0.5
Incentive Sensitization - Breakpoint	0.7	0.7	1.5	0.9	0.3	-1.2	-1.0	-0.5
Progressive ratio test 1 active lever presses	0.4	0.5	1.0	0.8	0.3	-1.0	-0.7	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.1	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.2	-0.5	-0.3	0.1
Progressive ratio test 2 active lever presses	1.5	1.6	2.9	1.5	0.8	-1.7	-1.4	-0.8
Progressive ratio test 2 breakpoint	1.2	1.3	2.7	1.4	0.6	-1.6	-1.2	-0.6
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.6	0.9	0.1	-1.3	-0.8	-0.2
Total sessions with >9 infusions	4.3	4.7	5.5	2.4	2.1	-2.2	-2.3	-2.0
Short access day 1 total inactive lever presses	1.1	1.3	2.0	1.4	0.9	-1.3	-1.1	-0.8
Short access day 10 total inactive lever presses	0.4	0.4	0.6	0.8	0.5	-0.7	-0.6	-0.5
Short access day 1 total infusions	0.6	0.6	0.8	0.9	0.6	-0.9	-0.9	-0.6
Short access day 10 total infusions	0.1	0.2	0.3	-0.0	-0.6	-0.2	0.2	0.6
Short access total infusions	0.3	0.3	0.8	0.7	-0.0	-0.9	-0.4	0.2
Short access day 1 locomotion	0.1	0.2	0.4	0.5	0.1	-0.7	-0.3	0.1
Short access day 10 total locomotion	1.2	1.3	2.5	0.8	1.3	-0.5	-1.2	-1.6
Short access total locomotion	0.6	0.6	1.1	0.6	0.9	-0.4	-0.8	-1.1
Compulsive drug intake	0.4	0.4	0.8	-0.3	-0.8	0.0	0.5	0.9
One hour access (0.3 mA shock)	1.2	1.4	4.1	1.5	0.0	-2.0	-0.9	0.2
One hour access (shock baseline)	1.2	1.3	2.2	1.4	0.8	-1.5	-1.2	-0.7
Number of responses in last shaping day	0.1	0.1	0.3	0.5	0.5	-0.2	-0.2	-0.3
Context. condit. distance diff. score	0.2	0.2	0.5	-0.6	-0.1	0.7	0.1	-0.2
Locomotion velocity, session 1	2.7	2.9	4.3	-1.7	-2.1	1.3	1.6	1.7
Locomotion distance, session 1	0.3	0.4	0.7	-0.8	-0.5	0.8	0.4	0.0
Locomotion velocity, session 2	0.6	0.7	2.0	-1.0	-0.3	1.4	0.4	-0.4
Locomotion distance, session 2	1.5	2.1	2.4	1.5	1.4	-1.4	-1.5	-1.4
Locomotion velocity, session 3	0.1	0.1	0.2	-0.1	0.1	0.1	-0.3	-0.4
Locomotion distance, session 3	0.4	0.5	1.2	0.2	0.8	0.1	-0.7	-1.1
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	0.3	0.2	-0.3	-0.1	0.0
Stereotopy head waving duration, day 3	0.9	1.1	1.6	-1.0	-1.2	0.6	1.0	1.2
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.2	-0.2
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.1	-0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.1	0.0	-0.5	-0.2	0.0
Stereotopy head waving duration, day 7	0.4	0.5	1.2	0.6	0.5	-1.1	-0.7	-0.3
Locomotion velocity, session 8	1.5	1.8	2.8	-1.5	-1.1	1.7	1.3	0.8
Locomotion distance, session 8	0.1	0.1	0.2	-0.4	0.1	0.5	-0.1	-0.5
Degree of sensitization distance	1.0	1.0	1.7	-0.8	-1.3	0.5	1.0	1.3
Degree of sensitization stereotypy	0.1	0.1	0.4	0.3	0.1	-0.6	-0.3	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.4	-0.7	0.2	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	-0.8	-0.9	0.5	0.6	0.7
Condit. Reinf. active responses	0.1	0.1	0.4	0.5	-0.2	-0.6	-0.3	0.1
Condit. Reinf. inactive responses	0.3	0.4	1.0	0.9	0.2	-1.0	-0.5	-0.0
Incentive salience index mean	0.8	1.0	1.7	-1.0	-1.3	0.8	0.9	0.9
Condit. Reinf. lever presses	1.0	1.3	2.2	-1.0	-1.5	1.0	1.1	1.1
Time in familiar zone, hab. session 1	0.3	0.3	0.9	-0.8	-0.0	0.9	0.4	-0.1
Time in novel zone, hab. session 1	0.7	0.7	2.1	0.9	0.2	-1.4	-0.8	-0.0
Total zone transitions, hab. session 1	1.7	2.4	2.8	1.5	1.5	-1.4	-1.7	-1.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.3	0.0	-0.5	-0.3	-0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.2	-0.0
Time in familiar zone, hab. session 2	2.2	2.3	5.2	1.9	1.0	-2.3	-1.3	-0.4
Time in novel zone, hab. session 2	0.7	0.7	2.1	-1.1	-0.3	1.4	0.6	-0.2
Total zone transitions, hab. session 2	2.5	3.3	3.9	2.0	1.7	-1.8	-1.9	-1.7
Total locomotion distance, hab. session 2	1.4	1.9	2.5	1.6	1.2	-1.3	-1.4	-1.2
Locomotion velocity, hab. session 2	0.8	1.1	1.4	1.2	0.9	-1.0	-1.1	-1.0
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.1	-0.3	-0.1	0.3	0.5
Novelty place preference	0.0	0.0	0.1	0.1	-0.1	-0.3	0.1	0.3
Time in novel zone, NPP test	0.2	0.2	0.6	0.5	0.1	-0.8	-0.2	0.2
Total zone transitions, NPP test	2.0	2.9	3.9	2.0	1.4	-1.9	-1.8	-1.4
Total locomotion distance, NPP test	1.4	2.0	3.0	1.7	1.1	-1.6	-1.4	-1.0
Locomotion velocity, NPP test	0.7	1.0	1.4	1.2	0.8	-1.0	-1.0	-0.9
Pavlov. Cond. lever latency	0.4	0.6	1.2	1.0	0.6	-1.1	-0.5	-0.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	0.9	0.5	-0.5	-0.6	-0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.0	0.1	0.2	-0.2	-0.5
Pavlov. Cond. index score	0.2	0.3	0.6	0.5	0.5	-0.1	-0.5	-0.8
Pavlov. Cond. latency score	0.1	0.2	0.4	0.4	0.3	0.0	-0.4	-0.6
Pavlov. Cond. lever contacts	0.4	0.4	0.7	-0.8	-0.7	0.9	0.6	0.3
Pavlov. Cond. magazine entry number	1.2	1.5	2.0	-1.4	-1.2	0.9	1.2	1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.4	0.3	-0.7	-0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.4	0.3	-0.1	-0.3	-0.6
Pavlov. Cond. response bias	0.1	0.2	0.5	0.3	0.3	0.0	-0.4	-0.7
Bone: apparent density	1.4	2.4	4.6	1.8	1.1	-2.2	-1.5	-0.8
Bone surface	0.9	1.5	2.6	1.1	0.9	-1.6	-1.4	-0.9
Bone volume	3.2	5.5	8.4	2.5	1.9	-2.9	-2.5	-1.7
Bone: connectivity density	0.0	0.1	0.1	-0.3	-0.3	0.1	0.2	0.2
Bone: cortical apparent density	0.9	1.2	3.4	-1.4	-0.0	1.8	0.4	-0.7
Bone: cortical area	9.2	13.9	20.2	3.7	3.1	-4.5	-4.2	-3.0
Bone: cortical porosity	0.1	0.1	0.3	0.2	-0.2	-0.5	-0.0	0.4
Bone: cortical porosity	0.2	0.3	0.7	0.7	-0.0	-0.9	-0.3	0.2
Bone: cortical thickness	4.8	7.9	9.9	2.7	2.6	-3.1	-3.1	-2.6
Bone: cortical thickness	2.8	3.3	4.4	1.5	1.8	-1.6	-2.1	-2.0
Bone: cortical tissue density	1.1	1.4	4.0	-1.5	-0.2	2.0	0.6	-0.5
Bone: elastic displacement	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.3
Bone: elastic work	1.7	2.3	3.1	1.3	1.6	-1.1	-1.7	-1.8
Bone: endosteal estimation	2.2	4.7	7.1	2.3	1.8	-2.7	-2.4	-1.6
Bone: endosteal perimeter	4.4	9.0	12.2	2.7	2.6	-3.5	-3.5	-2.6
Bone: final force	2.7	4.5	6.4	1.9	1.6	-2.5	-2.5	-1.9
Bone: final moment	3.4	5.7	7.8	2.2	1.9	-2.8	-2.8	-2.1
Bone: marrow area	2.3	4.9	7.3	2.3	1.8	-2.7	-2.4	-1.7
Bone: maximum diameter	7.3	13.4	20.9	3.7	2.9	-4.6	-4.0	-2.7
Bone: maximum force	2.4	4.1	6.2	1.7	1.6	-2.3	-2.5	-2.0
Bone: maximum moment	2.9	5.1	7.2	2.0	1.8	-2.6	-2.7	-2.1
Bone: minimum diameter	4.5	8.2	11.7	2.9	2.6	-3.4	-3.1	-2.2
Bone: periosteal estimation	7.0	14.4	20.1	3.8	3.2	-4.5	-4.2	-3.1
Bone: periosteal perimeter	10.1	16.8	23.0	3.9	3.6	-4.8	-4.5	-3.4
Bone: post-yield work	0.1	0.1	0.3	-0.1	-0.4	-0.5	-0.1	0.4
Bone: stiffness	0.8	1.3	2.5	0.5	0.7	-1.2	-1.6	-1.3
Bone: tissue strength	0.3	0.3	0.5	-0.4	-0.7	0.3	0.5	0.6
Bone: trabecular number	0.2	0.3	1.0	0.6	0.2	-1.0	-0.4	0.1
Bone: trabecular spacing	0.2	0.3	0.4	-0.5	-0.6	0.5	0.6	0.6
Bone: trabecular thickness	5.2	6.3	9.9	2.8	2.1	-3.2	-2.6	-1.7
Bone: trabecular tissue density	0.2	0.3	0.8	-0.1	0.6	-0.2	-0.7	-0.9
Breakpoint value in progressive ratio session	0.3	0.3	1.0	0.6	-0.2	-1.0	-0.2	0.5
Distance traveled before self-admin	0.4	0.5	1.0	-0.4	0.5	1.0	-0.1	-0.9
Distance traveled after self-admin	1.4	1.5	3.2	0.8	1.5	-0.2	-1.2	-1.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	0.4	0.3	-0.1	-0.4
Delta time in open arm before/after self-admin	0.4	0.4	1.1	0.7	-0.2	-1.0	-0.3	0.3
Diff in mean of infusions in LGA sessions	2.4	2.7	3.6	-1.9	-1.6	1.5	1.6	1.6
Extinction: sum of active levers before priming	0.5	0.5	1.4	-0.3	-0.8	-0.1	0.7	1.2
Active lever presses in extinction session 6	0.3	0.3	0.6	0.7	0.3	-0.8	-0.4	-0.1
Delta distance traveled before/after self-admin	2.1	2.3	2.6	1.6	1.5	-1.6	-1.6	-1.3
Delta ambulatory time before/after self-admin	1.7	1.8	3.2	1.6	1.0	-1.8	-1.3	-0.8
Time in closed arm before self-admin	0.2	0.3	0.5	0.4	0.5	-0.2	-0.6	-0.7
Time in closed arm after self-admin	0.1	0.1	0.3	-0.4	-0.1	0.6	0.3	-0.0
Time in open arm before self-admin	2.1	2.3	2.7	-1.6	-1.3	1.6	1.6	1.4
Time in open arm after self-admin	1.0	1.1	2.5	-0.6	-1.3	0.3	1.1	1.6
Sum of active levers in priming session hrs 5-6	2.2	2.1	2.4	-1.6	-1.3	1.4	1.5	1.4
Time to tail flick, vehicle, before self-admin	1.3	1.4	2.0	1.4	1.0	-1.4	-1.1	-0.8
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.1	0.4	0.3	-0.2	-0.6
Time to tail flick, test, before self-admin	1.6	1.6	2.9	1.0	1.5	-0.4	-1.2	-1.7
Time to tail flick, test, after self-admin	1.9	1.9	2.8	1.7	1.1	-1.6	-1.4	-1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.5	-0.3	0.6	0.2	0.0
Delta time to tail flick, test, before/after SA	0.7	0.6	1.4	0.9	0.4	-1.2	-0.7	-0.2
Ambulatory time before self-admin	0.9	1.0	2.4	0.3	1.2	0.2	-0.9	-1.6
Ambulatory time after self-admin	1.9	2.1	4.2	0.9	1.7	-0.4	-1.5	-2.0
Total heroin consumption	1.0	1.1	2.4	1.4	0.6	-1.6	-0.9	-0.2
Area under the delay curve	0.5	0.5	1.2	1.0	0.2	-1.1	-0.5	0.1
Delay disc. indifference point, 0s delay	1.0	1.0	1.6	1.2	0.9	-1.2	-1.0	-0.7
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.0	-0.6	-0.2	0.4	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.2
Delay disc. indifference point, 24s delay	0.5	0.5	1.2	0.8	-0.3	-1.1	-0.1	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.1	-0.3	-0.2	0.2	0.5
Delay disc. indifference point, 8s delay	2.1	2.1	4.3	1.9	0.9	-2.1	-1.3	-0.5
Delay discount exponential model param	0.5	0.6	1.4	-1.1	-0.2	1.2	0.5	-0.1
Delay discount hyperbolic model param	0.4	0.4	1.0	-0.9	-0.3	1.0	0.5	0.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.0	-0.3	-0.0	0.2	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.2	0.4	0.3	0.2
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.5	-1.2	-0.9	1.2	1.1	0.8
Bouts of movement, locomotor time 1	0.9	0.9	2.8	1.2	0.2	-1.7	-0.7	0.2
Total resting periods, locomotor time 1	0.9	1.0	2.8	1.2	0.3	-1.7	-0.8	0.0
Rest time, locomotor task time 1	0.3	0.4	0.4	0.5	0.6	-0.6	-0.6	-0.6
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	-0.1
Vertical activity count, locomotor time 1	0.3	0.3	1.1	-0.6	0.1	1.0	0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	0.8	0.5	-0.8	-0.6	-0.3
Bouts of movement, locomotor time 2	1.1	1.2	1.6	-1.3	-1.1	1.1	1.1	1.0
Total resting periods, locomotor time 2	0.5	0.6	0.7	-0.9	-0.8	0.7	0.8	0.7
Rest time, locomotor task time 2	0.1	0.1	0.2	0.1	0.3	0.2	-0.2	-0.5
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.4	-0.2	-0.6	0.0	0.5
Vertical activity count, locomotor time 2	0.2	0.2	0.4	0.7	0.4	-0.6	-0.4	-0.3
Weight adjusted by age	6.9	7.8	8.6	2.9	2.8	-2.7	-2.9	-2.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	-0.2	0.2	0.2	0.1
Locomotion in novel chamber	0.5	0.6	1.3	0.3	1.0	0.1	-0.7	-1.1
Locomotion in novel chamber post-restriction	0.9	1.0	2.1	-1.2	-0.6	1.4	1.0	0.5
Progressive ratio	1.1	1.3	1.8	-1.1	-1.3	0.8	1.2	1.4
Food seeking constrained by brief footshock	0.8	1.0	2.2	-0.6	-1.3	0.0	0.9	1.5
Seeking ratio, punishment vs. effort	0.3	0.3	0.4	0.6	0.4	-0.6	-0.6	-0.5
Run reversals in cocaine runway, females	1.0	1.0	1.5	0.9	1.2	-0.6	-1.0	-1.2
Run reversals in cocaine runway, males	1.8	1.8	2.3	-1.4	-1.5	1.1	1.3	1.4
Latency to leave start box in cocaine runway	0.8	0.9	1.3	-1.2	-0.7	1.2	0.9	0.6
Latency to leave start box in cocaine runway, F	0.9	1.0	2.1	-1.2	-0.5	1.5	0.9	0.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.1	-0.4	-0.0	0.2
Cd content in liver	2.7	2.9	3.5	-1.8	-1.7	1.4	1.8	1.9
Co content in liver	0.3	0.3	1.4	-0.3	0.2	1.2	0.4	-0.3
Cu content in liver	0.2	0.2	0.4	0.4	0.6	-0.1	-0.4	-0.6
Fe content in liver	0.1	0.1	0.2	0.5	0.3	-0.2	0.1	0.1
K content in liver	0.5	0.5	0.8	-0.3	-0.7	0.7	0.9	0.7
Mg content in liver	0.2	0.2	0.6	0.1	-0.6	-0.1	0.5	0.8
Mn content in liver	0.3	0.3	0.6	-0.6	-0.4	0.8	0.6	0.4
Na content in liver	1.5	1.6	2.3	-1.2	-1.5	0.8	1.2	1.5
Rb content in liver	1.9	2.3	3.8	-0.9	-1.6	1.0	1.8	2.0
Se content in liver	1.0	1.2	1.7	-1.2	-1.3	0.9	1.0	1.0
Sr content in liver	1.5	1.3	2.2	-1.4	-0.9	1.5	1.1	0.7
Zn content in liver	1.9	2.1	4.3	-1.6	-1.0	2.1	1.5	0.7