Hub : Genes

Kansl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000060185 0.12 0.08 8.6e-15 0.12 0.12 0.12 0.12 1.8e-13 5.3e-13 4.4e-13 5.9e-13
2 Adipose intron excision ratio chr7:129679805:129682769 0.02 0.02 4.1e-03 0.01 0.02 0.01 0.01 7.2e-03 5.6e-03 1.6e-02 1.1e-02
3 Adipose mRNA stability ENSRNOG00000060185 0.05 0.04 6.7e-06 0.04 0.04 0.03 0.03 5.6e-05 6.4e-05 4.3e-04 1.3e-04
4 BLA gene expression ENSRNOG00000060185 0.05 0.04 3.5e-03 0.03 0.02 0.03 0.03 7.1e-03 2.7e-02 1.2e-02 1.2e-02
5 BLA mRNA stability ENSRNOG00000060185 0.07 0.07 2.7e-03 0.02 0.04 0.03 0.02 3.8e-02 2.8e-03 1.1e-02 3.5e-02
6 Brain gene expression ENSRNOG00000060185 0.14 0.07 0.0e+00 0.22 0.22 0.21 0.21 7.1e-20 8.7e-20 4.1e-19 1.3e-19
7 Brain intron excision ratio chr7:129685147:129685358 0.02 0.02 4.8e-03 0.02 0.01 0 0.01 8.4e-03 3.1e-02 1.5e-01 3.9e-02
8 Brain intron excision ratio chr7:129685147:129685692 0.04 0.03 7.0e-04 0.03 0.03 0.02 0.02 1.5e-03 8.5e-04 6.1e-03 4.1e-03
9 Brain mRNA stability ENSRNOG00000060185 0.07 0.05 1.2e-08 0.08 0.09 0.08 0.09 3.3e-08 2.0e-08 1.4e-07 2.6e-08
10 LHb gene expression ENSRNOG00000060185 0.1 0.08 9.4e-03 0.03 0.07 0.05 0.06 6.9e-02 7.6e-03 2.1e-02 1.4e-02
11 NAcc mRNA stability ENSRNOG00000060185 0.03 0.03 2.4e-03 0.03 0.03 0.03 0.02 5.4e-03 4.3e-03 1.5e-03 1.2e-02
12 OFC gene expression ENSRNOG00000060185 0.24 0.13 1.3e-05 0.12 0.11 0.07 0.09 1.2e-03 1.4e-03 9.1e-03 3.8e-03
13 OFC mRNA stability ENSRNOG00000060185 0.13 0.09 2.5e-03 0.06 0.06 0.05 0.05 1.3e-02 1.5e-02 2.8e-02 2.2e-02
14 PL intron excision ratio chr7:129685147:129685618 0.04 0.03 4.0e-04 0.04 0.04 0.03 0.03 8.2e-04 7.0e-04 1.2e-03 1.9e-03
15 PL mRNA stability ENSRNOG00000060185 0.09 0.06 7.5e-09 0.07 0.09 0.07 0.08 4.3e-06 1.4e-07 4.5e-06 1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
BMI with tail4.815.618.14.1-4.0-4.2-3.9-3.74.23.8-4.1-3.73.9-3.83.6-4.2-3.9-3.9
BMI without tail0.10.10.70.4-0.2-0.7-0.8-0.10.4-0.0-0.3-0.20.2-0.2-0.2-0.6-0.2-0.2
Body weight6.829.033.35.5-5.4-5.7-5.7-5.25.55.0-5.4-5.25.4-5.35.0-5.8-5.4-5.4
Epididymis fat weight0.20.51.10.6-0.7-1.1-0.9-0.50.60.4-0.8-0.50.7-0.70.7-1.1-0.6-0.6
Glucose0.10.20.80.5-0.4-0.4-0.9-0.50.40.3-0.3-0.50.4-0.40.1-0.5-0.4-0.5
Heart weight0.00.00.20.2-0.20.20.4-0.1-0.00.3-0.30.00.1-0.10.20.0-0.2-0.1
Left kidney weight0.41.02.11.0-1.2-0.9-0.4-0.81.11.1-1.4-0.61.0-1.01.0-1.0-1.1-1.0
Right kidney weight2.98.28.82.8-2.9-2.8-2.9-2.82.92.8-2.9-2.82.9-3.02.9-2.9-2.9-2.9
Tail length0.10.20.2-0.40.40.4-0.30.4-0.3-0.50.50.3-0.40.4-0.40.30.40.4
Length with tail2.07.59.62.7-2.7-2.6-3.1-2.72.72.7-2.7-2.72.7-2.72.8-2.9-2.7-2.7
Length without tail7.516.418.44.2-4.2-4.0-3.7-4.04.04.1-4.3-3.84.1-4.04.0-4.1-4.1-4.1
Liver weight, left2.03.23.81.9-1.8-1.8-2.0-1.81.61.7-1.8-1.81.8-1.91.6-1.9-1.8-1.8
Liver weight, right1.72.94.31.7-1.7-1.9-2.1-1.61.51.6-1.7-1.71.7-1.71.4-1.8-1.7-1.7
Parametrial fat weight1.93.74.6-1.91.91.61.72.1-1.9-2.11.82.1-2.02.0-2.11.72.02.0
Retroperitoneal fat weight0.31.11.8-0.90.91.01.11.2-1.1-1.10.71.3-1.01.0-1.30.81.01.0
Intraocular pressure7.710.912.8-3.33.43.63.23.2-3.1-3.53.43.1-3.33.3-3.23.43.33.3
Extensor digitorum longus weight4.718.723.84.4-4.2-4.6-4.9-4.34.34.1-4.1-4.44.3-4.23.7-4.6-4.3-4.4
Soleus weight0.61.92.81.3-1.3-1.3-1.7-1.41.41.4-1.2-1.41.3-1.41.3-1.4-1.3-1.3
Tibialis anterior weight1.44.99.02.3-2.0-2.5-3.0-2.22.31.8-1.8-2.42.1-2.21.3-2.5-2.1-2.3
Tibia length7.922.224.74.9-4.7-4.4-5.0-4.75.04.6-4.6-4.74.7-4.74.6-4.7-4.7-4.7
Number of licking bursts0.20.20.7-0.20.60.30.30.2-0.3-0.60.70.1-0.40.4-0.90.30.40.3
Food consumed during 24 hour testing period1.62.02.91.4-1.5-1.3-1.2-1.31.31.7-1.7-1.11.4-1.31.6-1.3-1.4-1.4
Times rat made contact with spout0.00.00.2-0.00.1-0.10.30.3-0.1-0.1-0.00.3-0.20.3-0.5-0.10.10.1
Mean time between licks in bursts0.20.20.4-0.50.50.60.60.4-0.5-0.60.40.5-0.40.4-0.20.60.40.5
Mean num. licks in bursts0.00.10.3-0.2-0.10.10.30.4-0.10.2-0.40.5-0.10.20.20.10.10.1
Std. dev. time between licks in bursts0.91.01.4-1.01.11.00.80.9-1.0-1.21.10.9-1.01.0-1.01.01.01.0
Water consumed over 24 hours0.00.00.1-0.1-0.1-0.1-0.00.0-0.10.2-0.10.00.10.00.3-0.1-0.1-0.0
Indifference point 0 sec2.03.23.7-1.91.81.51.21.9-1.6-1.91.81.8-1.81.9-1.91.81.81.8
Indifference point AUC0.10.20.3-0.30.50.50.20.4-0.1-0.20.60.3-0.50.5-0.40.50.50.5
Indifference point function ln k3.55.05.52.1-2.3-2.3-2.1-2.22.02.2-2.3-2.22.3-2.22.3-2.2-2.3-2.3
Indifference point function log k3.55.05.52.1-2.3-2.3-2.1-2.22.02.2-2.3-2.22.3-2.22.3-2.2-2.3-2.3
Delay discounting total patch changes 0 sec1.93.13.5-1.91.81.51.11.8-1.6-1.81.81.7-1.81.9-1.91.81.81.8
Delay discounting total patch changes 12 sec1.62.12.8-1.41.61.31.01.4-1.2-1.51.71.3-1.51.6-1.71.51.51.5
Delay discounting total patch changes 18 sec3.74.96.2-2.32.42.21.42.2-2.1-2.22.52.0-2.32.4-2.22.22.32.3
Delay discounting total patch changes 24 sec1.62.03.0-1.61.61.20.71.3-1.4-1.31.71.1-1.51.5-1.51.41.51.5
Delay discounting total patch changes 6 sec2.23.44.0-1.81.91.81.51.8-1.6-1.81.91.8-1.91.9-1.92.01.91.9
Delay discounting time to switch 0 sec2.74.15.2-1.92.02.32.11.9-2.0-2.22.01.9-2.01.9-2.02.12.01.9
Delay discounting water rate 0 sec3.55.67.22.2-2.3-2.7-2.6-2.32.52.5-2.3-2.42.3-2.32.2-2.5-2.3-2.3
Delay discounting water rate 12 sec3.75.66.62.2-2.4-2.2-2.2-2.42.22.4-2.3-2.42.4-2.42.6-2.4-2.4-2.4
Delay discounting water rate 18 sec0.30.50.80.6-0.7-0.7-0.9-0.70.50.5-0.6-0.70.7-0.70.5-0.8-0.7-0.7
Delay discounting water rate 24 sec3.14.35.12.0-2.0-2.1-1.9-2.21.92.1-1.9-2.32.1-2.12.1-2.0-2.1-2.1
Delay discounting water rate 6 sec3.95.66.02.2-2.4-2.5-2.3-2.42.22.4-2.3-2.42.4-2.42.4-2.4-2.4-2.4
Locomotor activity0.81.31.7-1.21.21.11.11.1-1.2-1.21.31.0-1.21.0-1.21.11.21.1
Locomotor testing distance2.64.34.9-2.22.21.92.12.1-2.2-2.12.22.0-2.12.0-2.02.02.12.1
Locomotor testing rearing2.13.34.3-1.82.01.71.61.7-1.8-2.02.11.6-1.81.8-1.91.81.91.8
Light reinforcement 12.64.76.6-2.42.42.21.22.0-2.3-2.12.61.9-2.22.1-2.22.12.32.2
Light reinforcement 20.81.01.4-1.21.01.00.81.0-1.0-1.11.11.0-1.00.9-1.10.81.01.0
Reaction time number correct1.01.43.21.1-1.2-0.8-0.3-1.31.01.5-1.2-1.21.3-1.31.8-0.9-1.2-1.2
Reaction time mean minus median8.611.212.6-3.13.23.43.53.5-3.3-3.43.03.5-3.43.4-3.53.43.33.3
Reaction time mean minus median AUC6.48.29.2-2.72.72.92.93.0-2.9-3.02.63.0-2.92.8-2.92.92.82.9
Reaction time num false alarms1.92.63.3-1.61.61.71.71.6-1.4-1.41.51.6-1.61.6-1.41.81.61.6
Reaction time num false alarms AUC2.83.94.9-2.01.92.22.12.0-1.8-1.91.82.1-2.02.0-1.72.21.92.0
Reaction time trials correct on left1.01.43.21.1-1.2-0.8-0.3-1.31.01.5-1.2-1.21.3-1.31.8-0.9-1.2-1.2
Reaction time trials on left0.71.02.60.9-1.0-0.6-0.1-1.10.81.3-1.0-1.01.1-1.11.6-0.7-1.1-1.0
Reaction time mean0.50.71.2-0.70.80.80.90.9-0.8-1.10.70.9-0.80.8-1.00.70.80.8
Reaction time mean AUC0.30.40.7-0.50.50.60.80.7-0.6-0.80.40.7-0.60.5-0.80.50.60.6
Median of all reaction times0.00.10.20.3-0.3-0.2-0.2-0.20.2-0.0-0.3-0.20.2-0.30.1-0.4-0.2-0.3
Reaction time omissions10.213.814.7-3.83.73.83.83.8-3.8-3.63.63.8-3.73.6-3.63.73.73.7
Reaction time false alarm rate2.63.74.2-1.91.91.91.62.0-1.7-2.01.82.0-2.02.0-2.12.01.92.0
Reaction time premature initiation rate5.67.59.4-2.62.92.62.42.7-2.7-2.82.92.5-2.82.8-3.12.62.82.7
Reaction time premature initiations2.94.14.8-1.92.12.12.11.9-2.1-1.92.21.8-2.02.1-2.02.12.02.0
Std. dev. reaction times6.38.69.7-2.82.82.93.13.0-2.9-3.12.73.1-3.02.9-3.02.92.92.9
Reaction time trials completed0.71.02.60.9-1.0-0.6-0.1-1.10.81.3-1.0-1.01.1-1.11.6-0.7-1.1-1.0
Reaction time trials AUC1.31.83.91.2-1.4-1.0-0.4-1.51.11.6-1.4-1.41.4-1.42.0-1.0-1.4-1.3
Social response proportion0.10.10.4-0.20.30.60.40.3-0.3-0.40.30.4-0.30.4-0.40.50.30.3
Social responses7.810.112.0-2.93.33.43.03.0-3.1-3.23.33.0-3.23.3-3.33.53.23.1
Social time0.00.10.2-0.10.00.40.40.3-0.2-0.2-0.10.4-0.20.2-0.10.30.10.1
Conditioned locomotion0.00.00.20.2-0.0-0.1-0.2-0.40.00.10.1-0.50.2-0.30.3-0.1-0.2-0.2
Cocaine response after cond. corrected0.00.00.2-0.0-0.10.00.20.30.0-0.1-0.30.5-0.10.1-0.1-0.00.00.1
Cocaine response after cond. not corrected0.70.81.4-0.80.70.91.11.0-0.6-0.80.51.2-0.90.9-0.80.90.80.9
Cocaine response before conditioning4.15.06.4-2.22.32.52.42.0-2.0-1.92.42.0-2.22.2-2.02.52.22.2
Saline control response0.10.10.20.3-0.2-0.1-0.3-0.30.30.3-0.3-0.20.3-0.10.4-0.1-0.3-0.2
Condit. Reinf. active minus inactive responses0.00.00.1-0.30.20.2-0.10.2-0.20.00.30.1-0.20.2-0.10.20.20.2
Condit. Reinf. active-inactive response ratio0.30.30.4-0.60.60.50.50.6-0.5-0.50.60.6-0.60.6-0.60.60.60.6
Condit. Reinf. active responses0.20.30.4-0.60.60.60.20.5-0.6-0.40.60.4-0.50.5-0.40.60.60.6
Condit. Reinf. inactive responses0.70.81.2-1.01.01.10.70.8-0.9-0.91.10.7-0.90.9-0.81.10.90.9
Condit. Reinf. lever presses0.00.00.0-0.10.10.1-0.20.1-0.2-0.10.10.1-0.10.00.00.20.10.1
Condit. Reinf. lever reinforcers received0.60.81.0-1.00.90.90.60.9-1.0-0.81.00.8-0.90.9-0.81.00.90.9
Pavlov. Cond. lever latency0.00.00.00.0-0.00.0-0.0-0.00.00.1-0.0-0.00.0-0.10.20.0-0.0-0.0
Pavlov. Cond. magazine entry latency1.01.11.71.1-1.0-0.9-1.0-1.11.11.3-1.0-1.01.1-1.01.2-0.9-1.1-1.0
Pavlov. Cond. change in total contacts1.62.32.81.7-1.6-1.5-1.5-1.51.71.5-1.6-1.41.5-1.41.3-1.5-1.5-1.6
Pavlov. Cond. index score0.50.70.80.9-0.8-0.8-0.9-0.80.90.9-0.8-0.80.8-0.80.7-0.8-0.8-0.8
Pavlov. Cond. latency score0.60.80.90.9-0.9-0.9-0.9-0.90.91.0-0.9-0.80.9-0.80.8-0.8-0.9-0.9
Pavlov. Cond. lever contacts0.10.10.2-0.30.30.30.30.3-0.3-0.40.30.3-0.30.4-0.40.30.30.3
Pavlov. Cond. magazine entry number2.32.83.2-1.71.61.61.71.7-1.6-1.81.61.7-1.71.7-1.71.61.71.7
Pavlov. Cond. intertrial magazine entries4.96.37.2-2.62.52.42.72.6-2.5-2.42.42.6-2.52.5-2.72.42.52.5
Pavlov. Cond. lever-magazine prob. diff.0.91.21.41.2-1.1-1.0-1.1-1.11.11.2-1.1-1.11.1-1.01.0-1.0-1.1-1.1
Pavlov. Cond. response bias0.00.00.00.00.00.0-0.00.0-0.0-0.10.00.0-0.00.1-0.10.10.00.0
Conditioned reinforcement - actives1.41.41.7-1.21.31.31.11.2-1.1-1.21.31.2-1.21.1-1.11.21.21.2
Conditioned reinforcement - inactives1.61.82.1-1.21.31.31.31.4-1.3-1.41.31.4-1.41.3-1.31.21.41.3
Conditioned locomotion0.30.30.6-0.60.70.60.20.5-0.6-0.60.80.4-0.60.5-0.40.60.60.6
Intermittent access intake day 1-15 change1.21.21.6-1.01.01.01.21.2-1.2-1.20.91.2-1.11.0-1.21.01.11.1
Intermittent access intake escalation0.80.81.2-0.80.80.81.11.0-1.1-1.00.71.1-0.90.9-1.00.80.90.9
Intermittent access intake escalation 21.31.31.6-1.11.01.01.21.2-1.3-1.31.01.3-1.11.1-1.21.01.11.1
Intermitt. access day 1 inactive lever presses3.33.64.9-2.02.12.01.41.7-1.9-1.92.21.6-1.91.9-1.82.02.01.9
Intermitt. access day 15 inactive lever presses1.21.31.8-1.11.21.00.71.1-1.3-1.31.31.0-1.21.2-1.01.01.21.2
Intermitt. access escalation Index0.30.30.6-0.50.50.50.40.4-0.6-0.70.60.4-0.50.5-0.80.60.50.4
Intermittent access day 1 total infusions1.21.31.6-1.11.11.21.31.2-1.1-1.11.11.2-1.21.2-1.11.21.21.2
Intermittent access day 15 total infusions2.32.63.0-1.61.61.61.61.6-1.7-1.71.61.7-1.61.6-1.71.61.61.6
Intermittent access terminal intake (last 3 days)2.62.83.2-1.71.71.61.61.7-1.8-1.71.61.7-1.71.6-1.71.61.71.7
Intermittent access total infusions2.32.62.9-1.61.61.61.51.6-1.7-1.71.61.6-1.61.6-1.61.61.61.6
Intermittent access day 1 locomotion0.90.91.4-1.11.11.00.60.9-1.0-1.01.20.7-1.00.9-1.00.91.01.0
Intermittent access day 15 total locomotion1.21.32.0-1.21.31.00.61.1-1.3-1.31.40.9-1.21.0-1.20.91.21.1
Intermittent access total locomotion2.93.34.9-1.92.01.71.11.7-2.0-1.92.21.5-1.91.8-1.91.61.91.8
Intermittent access standard deviation0.50.50.9-0.60.70.70.90.7-0.7-0.80.60.8-0.70.6-0.80.80.70.7
Cocaine induced anxiety1.11.31.51.2-1.1-1.0-1.2-1.21.01.1-1.0-1.21.1-1.21.2-1.0-1.1-1.2
Post-drug Anxiety4.85.36.12.5-2.3-2.1-2.2-2.42.32.3-2.2-2.42.3-2.32.4-2.1-2.3-2.3
Baseline Anxiety1.11.21.51.2-1.1-1.2-1.0-1.01.11.0-1.2-1.01.1-1.00.9-1.2-1.1-1.1
Lifetime Intake2.02.22.7-1.51.51.41.31.5-1.6-1.61.41.5-1.51.5-1.61.31.51.4
Incentive Sensitization - Responses0.10.10.30.3-0.2-0.2-0.5-0.20.30.1-0.1-0.30.2-0.50.6-0.2-0.2-0.2
Incentive Sensitization - Breakpoint0.00.00.20.1-0.0-0.1-0.4-0.10.1-0.1-0.0-0.10.1-0.30.4-0.1-0.1-0.1
Progressive ratio test 1 active lever presses3.94.15.3-2.22.11.81.62.0-2.2-2.12.11.9-2.02.0-2.31.82.02.0
Progressive ratio test 1 breakpoint3.53.64.8-2.12.01.71.51.9-2.0-2.02.01.8-1.91.9-2.21.71.91.9
Progressive ratio test 1 inactive lever presses3.33.64.4-1.92.01.71.41.9-1.9-2.02.11.8-1.91.9-2.11.72.01.9
Progressive ratio test 2 active lever presses1.92.03.1-1.51.61.30.91.4-1.5-1.81.61.3-1.51.3-1.51.31.51.4
Progressive ratio test 2 breakpoint2.52.84.1-1.81.81.51.11.6-1.8-2.01.91.5-1.71.5-1.71.51.71.7
Progressive ratio test 2 inactive lever presses2.52.93.5-1.71.81.81.41.6-1.7-1.91.91.6-1.71.6-1.41.81.71.7
Total sessions with >9 infusions0.40.50.9-0.80.70.50.40.7-0.8-0.80.70.7-0.70.7-0.90.40.70.6
Short access day 1 total inactive lever presses1.11.32.0-1.11.11.00.81.1-1.2-1.41.21.1-1.11.1-1.31.01.11.1
Short access day 10 total inactive lever presses0.40.40.8-0.60.80.80.30.5-0.6-0.70.90.4-0.70.6-0.60.90.70.7
Short access day 1 total infusions0.00.00.1-0.1-0.0-0.3-0.20.1-0.2-0.2-0.10.00.0-0.0-0.2-0.3-0.0-0.1
Short access day 10 total infusions0.60.71.1-0.70.80.80.90.9-0.9-0.90.70.9-0.80.7-1.10.70.80.8
Short access total infusions0.20.20.6-0.50.50.30.30.5-0.6-0.60.50.5-0.50.5-0.70.30.50.4
Short access day 1 locomotion0.10.10.2-0.20.2-0.2-0.40.1-0.2-0.30.3-0.1-0.10.1-0.5-0.30.10.1
Short access day 10 total locomotion0.20.20.6-0.50.60.3-0.20.2-0.5-0.40.8-0.0-0.40.4-0.50.30.40.4
Short access total locomotion0.30.30.7-0.60.70.4-0.10.4-0.7-0.70.80.2-0.50.5-0.70.20.60.5
Compulsive drug intake0.80.81.20.9-1.0-0.8-0.8-0.91.10.9-1.0-0.80.9-0.70.9-0.7-0.9-0.9
One hour access (0.3 mA shock)0.10.20.3-0.30.40.40.40.4-0.4-0.50.30.5-0.40.3-0.50.40.40.4
One hour access (shock baseline)0.00.00.2-0.10.20.10.10.3-0.4-0.30.20.2-0.20.0-0.2-0.00.20.2
Number of responses in last shaping day0.20.21.10.4-0.3-0.7-1.0-0.4-0.10.0-0.2-0.50.3-0.40.1-0.7-0.3-0.4
Context. condit. distance diff. score0.30.30.50.6-0.6-0.6-0.7-0.60.50.3-0.5-0.60.6-0.50.4-0.6-0.6-0.6
Locomotion velocity, session 11.11.21.5-1.11.21.11.21.0-1.0-1.21.20.9-1.11.1-1.01.11.11.1
Locomotion distance, session 13.24.25.3-2.11.92.02.32.1-2.1-2.21.82.2-2.02.1-1.82.02.02.0
Locomotion velocity, session 20.30.40.9-0.60.50.71.00.6-0.5-0.50.50.6-0.60.6-0.40.70.50.6
Locomotion distance, session 22.63.75.0-1.91.82.02.22.0-1.9-2.11.72.1-1.91.9-1.71.91.91.9
Locomotion velocity, session 33.94.54.9-2.22.12.12.12.2-2.2-2.22.02.2-2.12.2-2.12.12.12.1
Locomotion distance, session 35.25.66.4-2.42.32.42.32.4-2.5-2.42.22.5-2.42.3-2.22.42.42.4
Stereotopy head waving bouts, day 31.21.41.81.1-1.1-1.1-0.7-1.31.31.3-1.1-1.31.2-1.21.3-1.1-1.2-1.2
Stereotopy head waving duration, day 30.50.60.90.7-0.7-0.7-0.2-0.90.90.9-0.7-0.80.8-0.70.8-0.6-0.8-0.7
Locomotion velocity, session 70.10.10.4-0.50.40.1-0.00.4-0.6-0.60.40.3-0.30.3-0.40.20.40.3
Locomotion distance, session 71.31.72.6-1.41.31.10.61.3-1.5-1.61.41.2-1.31.3-1.41.11.31.3
Stereotopy head waving bouts, day 71.01.21.81.0-1.0-1.0-0.9-1.31.21.3-0.9-1.31.1-1.11.1-1.0-1.1-1.1
Stereotopy head waving duration, day 71.31.52.21.2-1.1-1.2-1.0-1.41.41.5-1.0-1.41.2-1.21.2-1.2-1.2-1.2
Locomotion velocity, session 80.00.00.00.0-0.1-0.00.1-0.10.1-0.1-0.1-0.10.1-0.1-0.0-0.0-0.1-0.1
Locomotion distance, session 81.32.03.2-1.31.31.41.41.5-1.4-1.81.21.5-1.41.4-1.21.41.31.4
Degree of sensitization distance0.70.71.30.7-0.7-0.9-1.1-0.80.80.6-0.7-0.90.8-0.80.6-0.9-0.8-0.8
Degree of sensitization stereotypy0.30.30.60.5-0.4-0.5-0.5-0.70.60.7-0.3-0.70.5-0.50.4-0.4-0.5-0.5
Condit. Reinf. active minus inactive responses0.10.10.4-0.30.20.30.60.4-0.3-0.20.10.5-0.30.3-0.20.30.20.3
Condit. Reinf. active-inactive response ratio0.10.20.40.3-0.5-0.3-0.1-0.30.30.5-0.6-0.20.4-0.40.5-0.4-0.4-0.4
Condit. Reinf. active responses0.60.71.5-0.80.70.91.20.8-0.7-0.80.70.9-0.80.8-0.80.80.80.8
Condit. Reinf. inactive responses2.73.23.6-1.71.81.91.81.7-1.6-1.91.81.7-1.81.8-1.91.81.81.8
Incentive salience index mean0.00.10.10.2-0.3-0.2-0.0-0.20.30.2-0.4-0.10.2-0.30.1-0.3-0.3-0.3
Condit. Reinf. lever presses0.30.30.60.7-0.6-0.7-0.4-0.50.60.3-0.7-0.50.6-0.60.4-0.8-0.6-0.7
Time in familiar zone, hab. session 10.40.40.6-0.60.50.60.80.7-0.6-0.70.40.7-0.60.6-0.60.60.60.6
Time in novel zone, hab. session 10.40.30.70.5-0.4-0.6-0.8-0.70.60.5-0.3-0.80.6-0.60.5-0.5-0.5-0.6
Total zone transitions, hab. session 10.30.51.1-0.80.70.70.50.7-0.7-1.10.70.6-0.70.7-0.60.60.70.7
Total locomotion distance, hab. session 10.00.00.1-0.1-0.00.10.30.0-0.1-0.3-0.10.1-0.00.00.20.10.00.0
Locomotion velocity, hab. session 10.00.00.1-0.0-0.1-0.00.2-0.1-0.0-0.2-0.1-0.00.1-0.10.3-0.0-0.1-0.0
Time in familiar zone, hab. session 20.20.20.40.4-0.6-0.4-0.4-0.30.50.4-0.6-0.30.5-0.40.6-0.4-0.5-0.4
Time in novel zone, hab. session 20.20.20.6-0.50.60.40.30.3-0.5-0.40.80.1-0.50.4-0.60.50.50.4
Total zone transitions, hab. session 20.30.30.6-0.70.50.50.60.7-0.6-0.80.40.7-0.60.6-0.50.50.60.6
Total locomotion distance, hab. session 20.10.20.5-0.50.30.30.70.5-0.4-0.70.20.5-0.30.3-0.10.40.30.4
Locomotion velocity, hab. session 20.10.10.3-0.30.10.10.50.3-0.3-0.5-0.00.4-0.20.20.00.20.20.2
Novel to familiar place preference ratio1.81.93.21.4-1.3-1.4-1.8-1.51.41.5-1.1-1.61.4-1.41.2-1.3-1.3-1.4
Novelty place preference1.41.42.71.1-1.0-1.2-1.6-1.31.11.3-0.9-1.41.1-1.11.0-1.1-1.1-1.2
Time in novel zone, NPP test1.11.12.51.0-0.9-1.0-1.6-1.21.01.2-0.7-1.31.0-1.00.9-0.9-1.0-1.0
Total zone transitions, NPP test1.21.72.4-1.31.21.21.61.4-1.3-1.61.11.5-1.31.3-1.31.21.31.3
Total locomotion distance, NPP test1.92.63.6-1.61.51.61.91.6-1.6-1.81.41.7-1.61.6-1.41.61.61.6
Locomotion velocity, NPP test1.01.42.4-1.21.01.11.51.2-1.2-1.30.91.3-1.11.2-1.01.11.11.1
Pavlov. Cond. lever latency0.00.00.1-0.20.10.10.1-0.0-0.1-0.10.1-0.0-0.00.00.30.20.00.1
Pavlov. Cond. magazine entry latency0.00.00.00.0-0.1-0.00.10.10.00.2-0.20.20.00.00.1-0.0-0.00.0
Pavlov. Cond. change in total contacts0.10.10.30.5-0.3-0.3-0.3-0.30.40.4-0.4-0.30.3-0.30.1-0.3-0.3-0.4
Pavlov. Cond. index score0.10.20.30.5-0.4-0.5-0.5-0.30.40.4-0.4-0.30.4-0.40.1-0.6-0.4-0.5
Pavlov. Cond. latency score0.10.10.30.5-0.4-0.4-0.4-0.30.40.4-0.4-0.30.3-0.30.1-0.5-0.4-0.4
Pavlov. Cond. lever contacts0.20.20.6-0.30.40.40.30.5-0.3-0.40.40.5-0.50.5-0.80.30.40.4
Pavlov. Cond. magazine entry number0.00.00.0-0.10.0-0.0-0.1-0.10.1-0.10.1-0.20.1-0.10.10.0-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.40.51.6-0.70.60.71.30.7-0.6-0.50.60.8-0.70.7-0.60.70.70.7
Pavlov. Cond. lever-magazine prob. diff.0.40.50.70.8-0.7-0.8-0.7-0.60.70.7-0.8-0.60.7-0.70.4-0.9-0.7-0.8
Pavlov. Cond. response bias0.00.00.1-0.00.10.10.20.3-0.1-0.0-0.00.3-0.20.2-0.30.10.10.1
Bone: apparent density10.216.919.44.0-4.3-4.0-4.0-3.94.04.2-4.4-3.84.2-4.14.2-4.1-4.2-4.1
Bone surface12.021.123.04.5-4.7-4.5-4.5-4.54.54.8-4.8-4.44.7-4.64.7-4.5-4.7-4.6
Bone volume9.015.216.83.8-4.0-3.8-3.7-3.83.84.1-4.1-3.74.0-3.94.1-3.9-4.0-3.9
Bone: connectivity density7.211.313.43.3-3.5-3.2-3.2-3.23.33.5-3.7-3.03.4-3.33.5-3.3-3.4-3.3
Bone: cortical apparent density0.30.40.6-0.60.70.70.60.6-0.8-0.80.80.5-0.60.6-0.70.70.70.7
Bone: cortical area10.616.018.04.0-4.0-4.0-4.0-3.94.04.2-4.0-3.94.0-4.03.8-4.1-4.0-4.0
Bone: cortical porosity1.21.31.8-1.21.21.41.31.0-1.3-0.81.31.0-1.11.1-0.71.31.21.2
Bone: cortical porosity1.71.92.4-1.41.41.61.51.3-1.6-1.01.51.2-1.31.3-0.91.51.41.4
Bone: cortical thickness4.37.27.92.7-2.7-2.8-2.6-2.62.82.8-2.7-2.62.7-2.62.3-2.8-2.7-2.7
Bone: cortical thickness0.30.30.70.6-0.6-0.6-0.8-0.50.70.4-0.6-0.40.5-0.50.3-0.7-0.5-0.6
Bone: cortical tissue density0.50.60.8-0.80.80.80.70.7-0.9-0.90.90.6-0.80.7-0.70.80.80.8
Bone: elastic displacement5.05.76.4-2.52.42.42.32.3-2.5-2.32.42.3-2.42.4-2.42.42.42.4
Bone: elastic work0.00.00.1-0.40.20.30.10.1-0.4-0.10.20.1-0.10.1-0.00.20.10.2
Bone: endosteal estimation7.416.018.33.8-3.9-3.8-4.0-4.13.94.1-3.8-4.14.0-4.14.3-3.9-4.0-4.0
Bone: endosteal perimeter7.114.616.33.8-3.8-3.8-3.9-3.93.84.0-3.7-3.93.8-3.83.7-3.8-3.8-3.8
Bone: final force10.116.517.84.0-4.2-4.0-3.9-4.04.14.1-4.2-3.94.1-4.14.1-4.1-4.1-4.1
Bone: final moment10.216.918.54.0-4.2-4.0-3.9-4.04.14.1-4.3-3.94.2-4.14.2-4.1-4.2-4.1
Bone: marrow area7.315.617.73.8-3.9-3.8-4.0-4.03.94.0-3.8-4.04.0-4.04.2-3.8-4.0-3.9
Bone: maximum diameter4.58.29.52.8-2.8-2.9-3.1-2.82.93.1-2.7-2.92.8-2.82.6-2.9-2.8-2.9
Bone: maximum force13.723.825.94.8-5.0-4.7-4.9-4.84.84.8-4.9-4.85.0-4.95.1-4.8-4.9-4.9
Bone: maximum moment13.824.027.04.7-5.0-4.7-4.9-4.84.84.9-5.0-4.85.0-4.95.2-4.8-5.0-4.9
Bone: minimum diameter9.317.219.84.1-4.1-4.1-4.1-4.24.04.4-4.0-4.24.2-4.24.1-4.1-4.2-4.2
Bone: periosteal estimation12.425.427.74.9-5.0-5.0-5.1-5.05.05.3-5.0-5.05.1-5.15.1-5.0-5.1-5.0
Bone: periosteal perimeter10.817.920.44.2-4.3-4.2-4.2-4.24.24.5-4.3-4.14.2-4.24.1-4.2-4.3-4.2
Bone: post-yield work7.710.512.43.2-3.1-3.1-3.3-3.43.23.2-3.0-3.43.3-3.33.5-3.1-3.2-3.2
Bone: stiffness16.826.528.45.1-5.2-5.0-5.2-5.15.15.1-5.2-5.05.2-5.25.3-5.1-5.2-5.1
Bone: tissue strength0.70.71.20.8-0.9-0.7-0.8-0.90.70.7-0.8-0.90.9-0.91.1-0.8-0.9-0.8
Bone: trabecular number5.78.911.82.9-3.3-2.9-2.7-2.82.93.1-3.4-2.63.1-2.93.3-2.9-3.1-3.0
Bone: trabecular spacing2.02.53.9-1.51.81.51.51.4-1.6-1.62.01.2-1.61.6-1.71.61.71.6
Bone: trabecular thickness0.10.10.3-0.40.20.30.00.5-0.4-0.20.10.5-0.30.3-0.30.20.30.3
Bone: trabecular tissue density0.10.10.2-0.40.40.20.10.2-0.4-0.10.50.1-0.30.2-0.20.30.30.3
Breakpoint value in progressive ratio session0.10.20.30.5-0.4-0.3-0.4-0.50.40.5-0.4-0.40.4-0.40.2-0.3-0.4-0.4
Distance traveled before self-admin1.11.11.5-1.01.21.10.80.9-1.2-1.21.20.9-1.11.1-1.21.01.11.0
Distance traveled after self-admin0.20.20.3-0.40.40.30.40.5-0.4-0.40.40.5-0.40.5-0.40.30.40.4
Delta time in closed arm before/after self-admin0.20.20.50.4-0.6-0.30.1-0.30.50.6-0.7-0.10.4-0.40.6-0.4-0.5-0.4
Delta time in open arm before/after self-admin4.24.04.5-2.02.12.01.81.9-2.1-2.12.11.8-2.02.0-2.02.02.02.0
Diff in mean of infusions in LGA sessions1.31.51.91.2-1.3-1.1-0.9-1.21.21.2-1.4-1.11.3-1.41.3-1.1-1.3-1.3
Extinction: sum of active levers before priming0.40.40.70.6-0.6-0.7-0.8-0.70.50.7-0.5-0.70.6-0.60.6-0.6-0.6-0.6
Active lever presses in extinction session 60.40.40.60.7-0.7-0.7-0.5-0.60.60.7-0.7-0.50.7-0.60.6-0.6-0.7-0.7
Delta distance traveled before/after self-admin0.10.10.20.2-0.4-0.4-0.1-0.10.30.3-0.5-0.00.3-0.20.4-0.4-0.3-0.2
Delta ambulatory time before/after self-admin0.00.00.10.1-0.2-0.2-0.3-0.00.10.1-0.30.00.1-0.10.2-0.2-0.1-0.1
Time in closed arm before self-admin1.41.62.21.3-1.1-1.0-1.5-1.41.21.2-1.0-1.51.3-1.31.4-1.1-1.3-1.3
Time in closed arm after self-admin0.60.60.90.7-0.8-0.6-0.7-0.80.80.9-0.8-0.80.8-0.81.0-0.7-0.8-0.8
Time in open arm before self-admin0.80.91.40.9-0.9-1.1-1.2-0.80.80.8-0.9-0.90.9-0.90.8-1.1-0.9-0.9
Time in open arm after self-admin0.20.30.4-0.60.60.50.50.5-0.5-0.60.60.4-0.50.5-0.60.50.50.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.30.30.50.50.3-0.3-0.30.30.3-0.30.3-0.20.40.30.3
Time to tail flick, vehicle, before self-admin1.21.31.4-1.21.11.11.21.1-1.0-0.91.01.2-1.11.2-1.11.21.11.2
Time to tail flick, vehicle, after self-admin0.20.20.40.4-0.3-0.2-0.6-0.60.30.4-0.2-0.70.5-0.50.5-0.3-0.5-0.5
Time to tail flick, test, before self-admin0.50.50.9-0.60.60.80.90.7-0.7-0.70.60.7-0.60.6-0.50.70.70.7
Time to tail flick, test, after self-admin0.10.10.20.3-0.4-0.4-0.2-0.40.40.4-0.4-0.30.4-0.40.5-0.3-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.50.50.60.8-0.7-0.6-0.7-0.80.60.6-0.6-0.80.7-0.80.7-0.7-0.7-0.8
Delta time to tail flick, test, before/after SA0.30.20.50.4-0.4-0.7-0.6-0.40.50.5-0.4-0.50.5-0.30.3-0.5-0.4-0.5
Ambulatory time before self-admin3.94.14.9-2.02.12.01.61.9-2.1-2.22.21.8-2.02.0-2.22.02.12.0
Ambulatory time after self-admin1.61.72.1-1.31.41.30.91.3-1.4-1.41.51.2-1.31.3-1.41.31.41.3
Total heroin consumption2.12.53.31.6-1.4-1.7-1.8-1.71.41.5-1.2-1.81.6-1.61.4-1.6-1.5-1.6
Area under the delay curve1.21.31.81.2-1.2-1.3-1.2-1.01.20.9-1.3-1.01.1-1.10.8-1.3-1.1-1.1
Delay disc. indifference point, 0s delay1.41.62.01.2-1.2-1.3-1.4-1.21.31.4-1.1-1.31.2-1.31.2-1.4-1.2-1.2
Delay disc. indifference point, 16s delay1.31.32.21.1-1.1-1.4-1.5-1.11.11.0-1.1-1.11.1-1.10.9-1.4-1.1-1.1
Delay disc. indifference point, 2s delay1.21.41.51.2-1.2-1.1-1.1-1.21.21.1-1.2-1.21.2-1.21.2-1.1-1.2-1.2
Delay disc. indifference point, 24s delay1.61.51.91.4-1.2-1.3-1.4-1.21.31.1-1.2-1.21.2-1.21.1-1.3-1.2-1.2
Delay disc. indifference point, 4s delay0.20.30.60.5-0.7-0.6-0.4-0.30.50.3-0.8-0.20.5-0.50.4-0.7-0.5-0.5
Delay disc. indifference point, 8s delay3.13.24.01.9-1.9-2.0-1.7-1.61.81.6-2.0-1.61.8-1.71.5-2.0-1.8-1.8
Delay discount exponential model param1.01.11.5-1.11.11.21.10.9-1.1-0.81.20.9-1.01.0-0.81.21.11.0
Delay discount hyperbolic model param1.01.01.4-1.01.11.21.00.9-1.1-0.71.20.8-1.01.0-0.81.21.01.0
Fecal boli incidents, locomotor time 11.71.83.1-1.41.10.91.61.7-1.4-1.60.81.8-1.31.3-1.41.01.31.3
Change in fecal boli incidents, locomotor task1.21.11.71.0-1.0-0.9-1.1-1.11.01.0-0.9-1.11.1-1.21.3-0.9-1.1-1.0
Time >=10cm from walls, locomotor time 10.30.30.70.4-0.6-0.8-0.4-0.30.40.3-0.7-0.30.5-0.50.3-0.8-0.5-0.5
Bouts of movement, locomotor time 10.00.10.3-0.1-0.3-0.4-0.10.0-0.00.0-0.3-0.00.2-0.30.0-0.6-0.2-0.2
Total resting periods, locomotor time 10.10.20.3-0.60.20.20.30.5-0.5-0.50.20.5-0.30.3-0.50.00.40.4
Rest time, locomotor task time 10.20.30.4-0.60.40.40.40.6-0.5-0.70.30.6-0.50.5-0.70.20.50.5
Distance moved, locomotor task time 10.00.00.20.10.10.30.2-0.10.10.20.1-0.1-0.0-0.00.20.40.00.1
Vertical activity count, locomotor time 11.41.52.21.3-1.3-1.1-0.9-1.11.21.3-1.4-1.01.2-1.21.5-1.0-1.2-1.2
Time >=10cm from walls, locomotor time 20.40.40.6-0.70.70.40.50.7-0.8-0.80.70.7-0.70.6-0.70.50.70.7
Bouts of movement, locomotor time 22.93.13.51.7-1.6-1.9-1.8-1.81.81.6-1.5-1.91.7-1.81.9-1.8-1.7-1.7
Total resting periods, locomotor time 23.23.44.01.8-1.7-1.9-1.9-1.91.91.7-1.6-2.01.8-1.92.0-1.8-1.8-1.8
Rest time, locomotor task time 20.10.10.30.3-0.3-0.4-0.3-0.20.2-0.1-0.4-0.20.3-0.30.0-0.5-0.3-0.3
Distance moved, locomotor task time 20.20.20.4-0.40.50.60.50.4-0.4-0.10.50.4-0.40.4-0.20.60.40.5
Vertical activity count, locomotor time 20.10.10.40.2-0.2-0.4-0.6-0.20.20.4-0.2-0.30.2-0.20.4-0.3-0.2-0.2
Weight adjusted by age2.62.93.81.7-1.6-1.9-2.0-1.81.71.6-1.4-1.91.7-1.61.5-1.8-1.7-1.7
Seeking ratio, delayed vs. immediate footshock0.30.40.90.7-0.8-0.6-0.1-0.50.70.7-0.9-0.30.6-0.60.6-0.7-0.6-0.6
Locomotion in novel chamber0.60.81.30.9-0.8-1.2-0.8-0.91.00.9-0.8-0.90.9-0.80.8-0.8-0.9-0.9
Locomotion in novel chamber post-restriction0.10.20.70.1-0.3-0.8-0.8-0.20.10.1-0.2-0.30.3-0.30.2-0.6-0.2-0.2
Progressive ratio0.00.00.1-0.20.10.00.10.2-0.0-0.00.00.2-0.20.2-0.10.20.20.2
Food seeking constrained by brief footshock0.20.20.5-0.40.40.10.10.6-0.6-0.50.40.5-0.50.6-0.70.10.50.4
Seeking ratio, punishment vs. effort0.00.00.00.00.0-0.0-0.1-0.0-0.2-0.20.1-0.1-0.0-0.0-0.2-0.20.0-0.0
Run reversals in cocaine runway, females0.00.00.2-0.10.20.50.10.00.00.00.20.1-0.10.1-0.10.20.10.2
Run reversals in cocaine runway, males1.41.41.6-1.21.21.10.91.2-1.1-1.11.21.1-1.21.1-1.21.21.21.2
Latency to leave start box in cocaine runway0.00.00.0-0.10.10.20.00.10.10.00.10.0-0.10.1-0.10.10.10.1
Latency to leave start box in cocaine runway, F1.82.02.4-1.51.51.51.11.3-1.4-1.41.61.2-1.41.4-1.31.41.41.4
Latency to leave start box in cocaine runway, M2.12.02.51.4-1.5-1.4-1.1-1.31.61.5-1.5-1.31.4-1.41.4-1.4-1.4-1.4
Cd content in liver0.40.51.0-0.60.70.60.40.7-0.8-1.00.70.7-0.70.7-0.90.60.70.6
Co content in liver0.10.20.8-0.30.40.10.20.4-0.3-0.60.40.3-0.40.4-0.90.10.40.3
Cu content in liver0.91.01.61.2-1.1-1.3-0.7-1.00.70.8-1.1-1.01.0-1.10.6-1.2-1.1-1.1
Fe content in liver0.20.20.8-0.20.40.10.30.4-0.5-0.50.40.4-0.50.5-0.90.30.40.3
K content in liver0.40.41.00.7-0.7-1.0-0.5-0.50.60.4-0.7-0.50.6-0.60.4-0.9-0.7-0.7
Mg content in liver0.00.00.00.1-0.1-0.10.10.00.1-0.0-0.10.00.00.00.0-0.2-0.1-0.0
Mn content in liver0.00.00.1-0.1-0.1-0.2-0.0-0.20.10.2-0.0-0.20.2-0.20.3-0.1-0.1-0.1
Na content in liver0.00.00.2-0.10.2-0.00.10.1-0.2-0.50.20.0-0.10.1-0.40.00.10.1
Rb content in liver0.20.20.6-0.30.50.10.20.4-0.5-0.60.50.3-0.40.5-0.80.10.40.4
Se content in liver0.40.50.8-0.70.70.70.70.8-0.7-0.70.60.8-0.80.8-0.90.60.70.7
Sr content in liver0.70.71.30.8-0.8-0.9-1.1-0.70.70.8-0.7-0.80.8-0.70.5-1.0-0.8-0.8
Zn content in liver1.21.42.4-1.11.30.90.81.1-1.2-1.21.31.0-1.21.2-1.60.91.21.1