Tmbim6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA ENSRNOT00000088176 0.03 0.03 1.8e-03 0.01 0.01 0.01 0.01 1.2e-02 1.2e-02 9.7e-03 1.2e-02
2 Adipose alternative polyA ENSRNOT00000105911 0.03 0.03 2.0e-03 0.01 0.01 0.01 0.01 8.7e-03 1.6e-02 1.2e-02 1.8e-02
3 Adipose gene expression ENSRNOG00000055579 0.32 0.24 0.0e+00 0.17 0.16 0.17 0.16 5.1e-18 5.9e-18 4.7e-18 7.1e-18
4 BLA alternative TSS ENSRNOT00000088176 0.04 0.04 8.4e-03 0.01 0.01 0.01 0 7.0e-02 5.2e-02 1.1e-01 1.6e-01
5 Brain gene expression ENSRNOG00000055579 0.03 0.03 9.1e-03 0.03 0.01 0.01 0.02 1.5e-03 3.0e-02 6.7e-02 1.0e-02
6 Liver alternative polyA ENSRNOT00000088176 0.06 0.06 2.2e-06 0.05 0.05 0.05 0.05 2.8e-06 4.5e-06 1.8e-06 3.1e-06
7 Liver alternative polyA ENSRNOT00000105911 0.06 0.06 2.0e-06 0.04 0.04 0.04 0.04 1.8e-05 1.8e-05 1.0e-05 2.0e-05
8 Liver isoform ratio ENSRNOT00000084674 0.09 0.07 9.5e-10 0.08 0.08 0.08 0.08 2.4e-09 3.7e-09 2.1e-09 2.5e-09
9 Liver isoform ratio ENSRNOT00000105911 0.07 0.07 8.8e-08 0.06 0.06 0.06 0.06 3.5e-07 4.4e-07 3.0e-07 4.5e-07
10 Liver isoform ratio ENSRNOT00000106863 0.04 0.04 5.2e-04 0.03 0.03 0.03 0.03 6.2e-04 6.4e-04 7.8e-04 7.9e-04
11 Liver mRNA stability ENSRNOG00000055579 0.06 0.05 1.4e-06 0.04 0.04 0.04 0.04 1.1e-05 1.0e-05 1.9e-05 2.0e-05
12 PL intron excision ratio chr7:130527799:130535190 0.12 0.11 5.4e-03 0.01 0.01 -0 0 4.9e-02 7.6e-02 4.3e-01 1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail4.313.815.2-3.63.73.63.83.7-3.83.8-3.83.73.7-3.93.6
BMI without tail0.10.10.40.2-0.1-0.4-0.10.7-0.6-0.1-0.50.6-0.1-0.0-0.3
Body weight5.924.926.2-5.05.04.95.15.0-5.15.1-5.14.75.0-5.14.9
Epididymis fat weight0.10.20.5-0.70.50.60.60.1-0.20.6-0.20.10.5-0.50.7
Glucose0.20.31.1-0.1-0.00.2-0.0-1.00.9-0.00.9-1.0-0.00.10.1
Heart weight0.10.10.2-0.30.30.20.30.4-0.40.3-0.40.40.3-0.30.2
Left kidney weight0.82.35.2-1.11.11.01.22.3-2.11.1-2.11.91.1-1.31.0
Right kidney weight2.77.89.6-3.02.62.62.73.1-3.12.7-3.12.62.6-2.72.6
Tail length0.10.20.40.4-0.5-0.7-0.60.1-0.1-0.5-0.0-0.1-0.50.5-0.6
Length with tail2.17.58.8-2.72.62.72.72.9-3.02.7-3.02.62.6-2.72.7
Length without tail6.915.117.0-4.04.04.14.13.5-3.64.1-3.63.44.0-4.04.1
Liver weight, left1.62.63.1-1.61.71.71.81.3-1.51.7-1.51.41.7-1.81.6
Liver weight, right1.62.63.0-1.51.61.61.61.7-1.71.6-1.71.51.6-1.61.6
Parametrial fat weight2.14.15.02.1-2.2-2.1-2.1-1.71.9-2.21.9-1.6-2.22.0-2.1
Retroperitoneal fat weight0.82.63.41.4-1.6-1.3-1.6-1.81.8-1.51.8-1.8-1.61.6-1.3
Intraocular pressure6.89.610.93.2-3.2-3.2-3.3-2.72.8-3.32.8-2.8-3.23.3-3.3
Extensor digitorum longus weight4.116.520.0-3.63.93.64.14.4-4.44.0-4.44.53.9-4.23.6
Soleus weight0.82.33.4-1.31.31.21.51.8-1.81.5-1.81.81.3-1.61.3
Tibialis anterior weight1.55.310.7-1.31.81.31.93.2-3.11.8-3.03.31.8-2.11.4
Tibia length6.017.020.9-4.64.24.64.43.5-3.74.3-3.73.34.2-4.34.5
Number of licking bursts1.21.42.70.8-1.0-0.7-1.0-1.61.6-1.01.6-1.5-1.01.1-0.8
Food consumed during 24 hour testing period1.61.92.3-1.51.41.51.51.3-1.31.4-1.31.31.4-1.51.5
Times rat made contact with spout0.10.10.20.4-0.4-0.4-0.3-0.10.2-0.40.2-0.1-0.40.3-0.4
Mean time between licks in bursts0.00.00.00.1-0.1-0.1-0.10.2-0.1-0.1-0.1-0.0-0.10.1-0.1
Mean num. licks in bursts0.40.51.5-0.20.40.10.41.2-1.10.4-1.11.10.4-0.50.1
Std. dev. time between licks in bursts1.21.51.81.1-1.3-1.1-1.3-1.11.1-1.31.1-1.3-1.31.3-1.1
Water consumed over 24 hours0.00.00.1-0.20.00.20.0-0.30.30.10.3-0.30.00.00.2
Indifference point 0 sec3.96.310.52.0-2.1-1.9-2.3-3.13.0-2.23.0-3.2-2.12.5-2.0
Indifference point AUC0.40.40.70.5-0.7-0.5-0.6-0.80.8-0.70.8-0.6-0.70.6-0.5
Indifference point function ln k4.76.77.8-2.42.52.32.62.8-2.82.5-2.82.82.5-2.62.4
Indifference point function log k4.76.77.8-2.42.52.32.62.8-2.82.5-2.82.82.5-2.62.4
Delay discounting total patch changes 0 sec3.75.99.82.0-2.1-1.8-2.3-3.12.9-2.12.9-3.1-2.12.4-1.9
Delay discounting total patch changes 12 sec3.85.18.51.8-2.0-1.7-2.1-2.62.6-2.02.6-2.9-2.02.3-1.8
Delay discounting total patch changes 18 sec6.07.911.22.3-2.6-2.2-2.7-3.33.3-2.63.2-3.4-2.62.8-2.3
Delay discounting total patch changes 24 sec3.44.36.31.7-1.9-1.6-2.0-2.52.5-1.82.4-2.5-1.92.1-1.6
Delay discounting total patch changes 6 sec4.36.511.22.0-2.2-1.9-2.4-3.23.1-2.23.0-3.4-2.22.6-2.0
Delay discounting time to switch 0 sec2.23.44.11.9-1.9-1.8-1.9-1.71.7-2.01.7-2.0-1.92.0-1.8
Delay discounting water rate 0 sec2.84.55.3-2.11.92.12.22.1-2.12.2-2.12.31.9-2.22.1
Delay discounting water rate 12 sec3.35.06.4-2.52.42.42.41.7-1.82.3-1.82.02.4-2.42.5
Delay discounting water rate 18 sec0.30.40.7-0.50.60.50.60.8-0.80.6-0.80.80.6-0.60.5
Delay discounting water rate 24 sec3.85.26.3-2.12.22.12.32.3-2.32.2-2.32.52.2-2.42.2
Delay discounting water rate 6 sec4.46.58.2-2.42.32.42.52.7-2.72.4-2.72.92.3-2.62.4
Locomotor activity1.01.52.41.3-1.4-1.5-1.5-0.60.7-1.40.8-0.9-1.41.5-1.4
Locomotor testing distance2.84.76.22.2-2.2-2.3-2.4-1.81.9-2.31.9-2.0-2.22.5-2.2
Locomotor testing rearing2.23.44.21.9-1.7-1.9-2.0-1.61.7-2.01.7-1.8-1.72.1-1.9
Light reinforcement 12.24.15.52.3-2.2-2.3-2.2-1.51.6-2.21.6-1.4-2.22.1-2.3
Light reinforcement 20.50.71.61.1-0.9-1.3-0.90.3-0.2-0.9-0.1-0.1-0.90.8-1.2
Reaction time number correct1.72.43.0-1.71.71.61.61.2-1.31.7-1.31.21.7-1.61.7
Reaction time mean minus median8.210.711.83.3-3.4-3.3-3.4-3.03.1-3.43.2-3.0-3.43.4-3.4
Reaction time mean minus median AUC5.97.58.42.7-2.8-2.7-2.8-2.62.7-2.92.7-2.5-2.82.8-2.8
Reaction time num false alarms1.62.32.61.4-1.6-1.4-1.5-1.51.5-1.61.5-1.4-1.61.6-1.4
Reaction time num false alarms AUC2.13.03.41.7-1.8-1.7-1.8-1.61.7-1.81.7-1.5-1.81.8-1.7
Reaction time trials correct on left1.72.43.0-1.71.71.61.61.2-1.31.7-1.31.21.7-1.61.7
Reaction time trials on left1.31.92.4-1.51.51.41.51.1-1.11.5-1.11.11.5-1.41.5
Reaction time mean0.81.11.20.9-1.1-1.0-1.1-0.91.0-1.11.0-1.1-1.11.1-1.0
Reaction time mean AUC0.40.60.70.7-0.8-0.8-0.8-0.50.7-0.80.7-0.7-0.80.8-0.7
Median of all reaction times0.00.00.0-0.1-0.10.0-0.00.10.0-0.10.0-0.1-0.10.00.1
Reaction time omissions9.112.314.13.6-3.6-3.8-3.8-3.03.2-3.63.3-3.1-3.63.8-3.7
Reaction time false alarm rate2.63.74.52.0-2.1-1.9-2.0-1.71.7-2.11.8-1.6-2.12.0-2.0
Reaction time premature initiation rate5.87.810.63.2-2.9-3.3-3.1-2.02.1-2.92.2-2.0-2.93.1-3.2
Reaction time premature initiations2.33.34.92.1-1.9-2.2-2.1-1.21.3-1.91.3-1.2-1.92.0-2.1
Std. dev. reaction times6.38.69.32.9-3.0-3.0-3.0-2.72.9-3.12.9-2.8-3.03.0-3.0
Reaction time trials completed1.31.92.4-1.51.51.41.51.1-1.11.5-1.11.11.5-1.41.5
Reaction time trials AUC2.13.03.7-1.91.91.81.81.4-1.41.9-1.51.41.9-1.81.9
Social response proportion0.10.10.30.3-0.4-0.5-0.4-0.10.2-0.50.2-0.1-0.40.4-0.5
Social responses7.79.911.33.3-3.3-3.3-3.3-2.82.9-3.42.9-2.7-3.33.3-3.3
Social time0.20.20.80.10.2-0.20.20.9-0.70.1-0.70.90.2-0.2-0.2
Conditioned locomotion0.10.10.2-0.30.10.30.1-0.40.40.10.4-0.20.1-0.10.2
Cocaine response after cond. corrected0.00.00.10.00.0-0.0-0.00.4-0.30.0-0.30.10.0-0.0-0.0
Cocaine response after cond. not corrected0.30.40.60.8-0.7-0.8-0.7-0.30.3-0.70.4-0.4-0.70.7-0.7
Cocaine response before conditioning3.23.94.22.0-2.0-2.0-2.0-1.91.9-2.01.9-1.7-2.02.0-2.0
Saline control response0.10.10.3-0.40.40.50.3-0.50.30.40.3-0.30.4-0.30.5
Condit. Reinf. active minus inactive responses0.10.10.50.1-0.1-0.10.10.4-0.4-0.0-0.40.7-0.1-0.3-0.1
Condit. Reinf. active-inactive response ratio0.20.20.40.6-0.5-0.7-0.30.3-0.2-0.4-0.10.5-0.50.1-0.6
Condit. Reinf. active responses0.10.10.20.4-0.4-0.4-0.3-0.00.1-0.40.10.2-0.40.2-0.4
Condit. Reinf. inactive responses0.50.70.90.8-0.8-0.8-0.9-0.70.8-0.80.8-0.8-0.80.9-0.8
Condit. Reinf. lever presses0.00.00.1-0.00.00.10.0-0.30.2-0.00.2-0.00.0-0.00.1
Condit. Reinf. lever reinforcers received0.30.50.60.8-0.8-0.8-0.7-0.60.6-0.80.6-0.3-0.80.6-0.8
Pavlov. Cond. lever latency0.50.72.4-0.20.30.10.41.5-1.40.3-1.31.20.3-0.50.1
Pavlov. Cond. magazine entry latency0.70.81.3-1.11.01.20.9-0.60.41.00.3-0.51.0-0.71.1
Pavlov. Cond. change in total contacts0.81.11.7-1.31.21.31.20.3-0.41.2-0.50.61.2-1.21.3
Pavlov. Cond. index score0.50.61.5-0.70.60.80.5-1.21.00.60.9-0.90.6-0.30.8
Pavlov. Cond. latency score0.50.61.5-0.80.60.80.5-1.20.90.60.8-0.90.6-0.40.8
Pavlov. Cond. lever contacts0.60.82.40.5-0.5-0.4-0.6-1.61.4-0.51.3-1.2-0.50.7-0.4
Pavlov. Cond. magazine entry number1.21.52.71.6-1.4-1.6-1.30.4-0.1-1.5-0.00.2-1.41.2-1.6
Pavlov. Cond. intertrial magazine entries4.15.37.02.6-2.6-2.6-2.6-1.41.7-2.61.7-1.5-2.62.5-2.6
Pavlov. Cond. lever-magazine prob. diff.0.60.71.2-1.00.91.10.8-0.90.70.90.5-0.60.9-0.61.0
Pavlov. Cond. response bias0.30.41.60.1-0.2-0.1-0.2-1.31.1-0.21.0-1.0-0.20.3-0.1
Conditioned reinforcement - actives1.51.52.11.3-1.2-1.5-1.3-1.01.0-1.31.0-0.9-1.21.3-1.5
Conditioned reinforcement - inactives2.32.63.01.5-1.7-1.7-1.7-1.51.5-1.61.5-1.5-1.71.7-1.7
Conditioned locomotion0.50.61.20.6-1.1-0.9-0.7-0.50.6-0.70.6-0.6-1.10.7-0.9
Intermittent access intake day 1-15 change1.11.11.81.2-1.1-1.3-1.2-0.60.7-1.30.8-0.4-1.11.1-1.3
Intermittent access intake escalation0.70.71.21.0-0.9-1.1-0.9-0.20.4-1.10.4-0.0-0.90.8-1.1
Intermittent access intake escalation 21.11.11.91.2-1.1-1.4-1.2-0.50.7-1.40.7-0.4-1.11.1-1.4
Intermitt. access day 1 inactive lever presses1.51.63.71.9-1.3-1.6-1.4-0.70.8-1.30.8-0.8-1.31.3-1.6
Intermitt. access day 15 inactive lever presses0.80.91.61.1-1.3-1.2-1.0-0.30.4-1.00.5-0.2-1.30.9-1.2
Intermitt. access escalation Index0.40.30.90.5-0.4-0.3-0.5-0.80.7-0.40.7-0.9-0.40.6-0.3
Intermittent access day 1 total infusions1.21.41.71.1-1.2-1.3-1.3-1.11.1-1.21.1-1.1-1.21.3-1.3
Intermittent access day 15 total infusions2.52.83.61.7-1.7-1.9-1.9-1.31.4-1.91.5-1.2-1.71.8-1.9
Intermittent access terminal intake (last 3 days)2.72.93.91.6-1.8-1.9-1.9-1.41.5-2.01.5-1.3-1.81.9-1.9
Intermittent access total infusions2.52.83.61.6-1.7-1.9-1.8-1.31.4-1.91.4-1.3-1.71.8-1.9
Intermittent access day 1 locomotion1.11.11.51.0-1.2-1.0-1.0-1.01.0-0.91.0-1.0-1.21.1-1.0
Intermittent access day 15 total locomotion1.82.02.61.2-1.6-1.6-1.4-1.21.3-1.41.3-1.1-1.61.4-1.6
Intermittent access total locomotion4.04.55.31.9-2.3-2.2-2.1-2.02.1-2.02.1-2.1-2.32.2-2.2
Intermittent access standard deviation0.40.40.70.8-0.8-0.8-0.60.10.1-0.70.10.1-0.80.6-0.8
Cocaine induced anxiety1.41.62.5-1.11.61.11.11.2-1.31.2-1.41.21.6-1.11.1
Post-drug Anxiety5.76.37.7-2.42.82.42.52.4-2.52.4-2.62.52.8-2.52.4
Baseline Anxiety0.80.91.0-1.00.91.01.00.8-0.80.9-0.80.90.9-1.01.0
Lifetime Intake2.83.13.81.6-1.8-1.9-1.9-1.61.6-2.01.6-1.5-1.81.9-1.9
Incentive Sensitization - Responses0.10.10.2-0.30.3-0.10.10.3-0.30.0-0.30.40.3-0.1-0.1
Incentive Sensitization - Breakpoint0.00.00.1-0.20.1-0.2-0.10.2-0.2-0.1-0.20.30.1-0.0-0.2
Progressive ratio test 1 active lever presses6.26.48.32.1-2.4-2.4-2.6-2.72.7-2.52.7-2.9-2.42.7-2.4
Progressive ratio test 1 breakpoint5.65.77.22.0-2.2-2.3-2.5-2.62.5-2.42.5-2.7-2.22.6-2.3
Progressive ratio test 1 inactive lever presses3.23.44.82.0-1.8-2.2-2.0-1.51.6-1.81.6-1.5-1.82.0-2.2
Progressive ratio test 2 active lever presses2.52.63.21.4-1.6-1.8-1.8-1.51.5-1.71.5-1.5-1.61.8-1.8
Progressive ratio test 2 breakpoint3.03.44.11.7-1.8-2.0-2.0-1.61.6-2.01.6-1.7-1.82.0-2.0
Progressive ratio test 2 inactive lever presses2.22.63.61.5-1.8-1.9-1.7-1.21.3-1.71.3-1.2-1.81.7-1.9
Total sessions with >9 infusions1.51.61.90.8-1.2-1.3-1.4-1.31.3-1.41.3-1.3-1.21.4-1.3
Short access day 1 total inactive lever presses1.61.82.21.3-1.5-1.4-1.4-1.11.2-1.41.2-1.2-1.51.4-1.4
Short access day 10 total inactive lever presses0.10.10.40.7-0.4-0.4-0.20.10.0-0.20.0-0.0-0.40.1-0.4
Short access day 1 total infusions0.20.20.50.1-0.2-0.4-0.5-0.70.6-0.50.6-0.7-0.20.6-0.4
Short access day 10 total infusions1.92.13.11.0-1.4-1.3-1.4-1.61.6-1.41.6-1.8-1.41.5-1.3
Short access total infusions1.11.31.80.7-0.9-1.0-1.2-1.31.3-1.21.3-1.3-0.91.2-1.0
Short access day 1 locomotion0.20.30.40.3-0.5-0.5-0.5-0.50.5-0.40.5-0.7-0.50.5-0.5
Short access day 10 total locomotion0.20.20.50.4-0.7-0.4-0.4-0.40.3-0.20.3-0.7-0.70.4-0.4
Short access total locomotion0.60.70.90.7-0.9-0.9-0.8-0.70.8-0.70.8-0.9-0.90.8-0.9
Compulsive drug intake1.41.42.2-0.91.21.21.21.3-1.21.1-1.11.51.2-1.21.2
One hour access (0.3 mA shock)0.20.30.60.5-0.5-0.8-0.60.10.1-0.80.10.3-0.50.5-0.8
One hour access (shock baseline)0.20.20.50.3-0.5-0.7-0.6-0.10.1-0.60.1-0.0-0.50.5-0.7
Number of responses in last shaping day0.10.10.2-0.20.4-0.00.20.4-0.40.1-0.40.20.4-0.20.0
Context. condit. distance diff. score0.20.20.3-0.50.60.50.50.4-0.50.6-0.50.30.6-0.50.5
Locomotion velocity, session 11.92.04.21.1-1.1-1.0-1.3-1.91.8-1.01.7-2.0-1.11.4-1.1
Locomotion distance, session 12.63.43.71.8-1.7-1.9-1.9-1.81.9-1.71.9-1.9-1.71.9-1.9
Locomotion velocity, session 20.20.20.40.4-0.5-0.4-0.5-0.60.6-0.50.6-0.5-0.50.5-0.4
Locomotion distance, session 22.43.44.11.7-1.7-1.7-1.9-2.02.0-1.72.0-2.0-1.71.9-1.7
Locomotion velocity, session 34.55.26.12.1-2.2-2.1-2.3-2.42.5-2.22.5-2.4-2.22.4-2.1
Locomotion distance, session 34.24.65.82.2-2.4-2.2-2.4-1.71.8-2.41.9-1.6-2.42.3-2.2
Stereotopy head waving bouts, day 30.70.81.9-1.30.91.40.90.3-0.30.9-0.30.20.9-0.91.3
Stereotopy head waving duration, day 30.30.40.9-0.90.71.00.7-0.10.00.7-0.0-0.10.7-0.60.9
Locomotion velocity, session 70.91.02.70.4-0.7-0.3-0.9-1.31.3-0.81.3-1.7-0.71.0-0.4
Locomotion distance, session 72.43.15.01.4-1.7-1.3-1.8-1.92.0-1.71.9-2.2-1.71.9-1.4
Stereotopy head waving bouts, day 70.70.81.2-1.10.81.10.90.8-0.80.8-0.80.70.8-0.91.1
Stereotopy head waving duration, day 71.11.31.5-1.21.11.21.21.1-1.11.1-1.11.11.1-1.21.2
Locomotion velocity, session 80.10.20.60.00.1-0.0-0.1-0.70.70.00.6-0.60.10.2-0.0
Locomotion distance, session 81.11.72.11.3-1.2-1.3-1.3-1.31.4-1.21.3-1.5-1.21.3-1.3
Degree of sensitization distance0.30.30.5-0.70.60.70.50.1-0.20.7-0.2-0.10.6-0.50.7
Degree of sensitization stereotypy0.30.30.7-0.30.30.30.50.8-0.70.4-0.70.80.3-0.50.3
Condit. Reinf. active minus inactive responses0.10.10.10.2-0.3-0.2-0.3-0.20.2-0.30.3-0.3-0.30.3-0.2
Condit. Reinf. active-inactive response ratio0.20.20.4-0.60.50.60.50.4-0.40.4-0.40.30.5-0.50.6
Condit. Reinf. active responses0.70.81.00.8-0.9-0.8-0.9-0.90.9-0.91.0-1.0-0.90.9-0.8
Condit. Reinf. inactive responses2.93.43.71.9-1.8-1.9-1.9-1.81.8-1.81.8-1.8-1.81.9-1.9
Incentive salience index mean0.00.00.0-0.10.10.10.10.1-0.10.0-0.1-0.00.1-0.10.1
Condit. Reinf. lever presses0.20.30.8-0.30.40.30.40.9-0.80.4-0.80.80.4-0.50.3
Time in familiar zone, hab. session 10.10.10.30.5-0.4-0.5-0.40.00.0-0.40.10.1-0.40.3-0.5
Time in novel zone, hab. session 10.20.10.3-0.50.40.50.40.1-0.10.5-0.20.10.4-0.40.5
Total zone transitions, hab. session 10.20.30.60.7-0.5-0.8-0.6-0.40.4-0.50.4-0.4-0.50.6-0.7
Total locomotion distance, hab. session 10.10.10.3-0.20.00.3-0.0-0.60.50.00.5-0.60.00.10.2
Locomotion velocity, hab. session 10.10.10.2-0.30.10.30.1-0.50.40.10.4-0.50.10.00.3
Time in familiar zone, hab. session 20.80.81.6-0.60.70.50.81.2-1.20.8-1.11.30.7-0.90.6
Time in novel zone, hab. session 20.80.81.90.5-0.6-0.5-0.7-1.31.3-0.61.2-1.4-0.60.8-0.5
Total zone transitions, hab. session 20.30.40.40.6-0.5-0.6-0.6-0.60.6-0.50.6-0.6-0.50.6-0.6
Total locomotion distance, hab. session 20.20.30.70.1-0.3-0.1-0.4-0.80.8-0.40.8-0.7-0.30.4-0.1
Locomotion velocity, hab. session 20.10.10.4-0.0-0.20.1-0.2-0.60.6-0.20.6-0.5-0.20.30.1
Novel to familiar place preference ratio1.51.62.0-1.31.31.31.41.0-1.11.4-1.11.01.3-1.41.3
Novelty place preference1.01.01.5-1.11.11.11.20.7-0.71.2-0.80.71.1-1.11.1
Time in novel zone, NPP test0.80.81.2-1.01.01.01.00.5-0.61.1-0.60.51.0-1.01.0
Total zone transitions, NPP test1.82.53.91.4-1.4-1.4-1.6-1.91.8-1.41.8-2.0-1.41.7-1.4
Total locomotion distance, NPP test2.33.14.91.3-1.5-1.3-1.7-2.22.2-1.62.1-2.1-1.51.8-1.3
Locomotion velocity, NPP test1.41.93.41.0-1.2-0.9-1.3-1.81.8-1.21.8-1.8-1.21.4-1.0
Pavlov. Cond. lever latency0.10.20.4-0.40.50.40.4-0.40.30.60.2-0.40.5-0.30.4
Pavlov. Cond. magazine entry latency0.30.41.3-0.10.20.00.31.1-1.00.1-1.01.10.2-0.40.0
Pavlov. Cond. change in total contacts0.40.41.4-0.00.0-0.00.21.2-1.1-0.0-1.01.10.0-0.30.0
Pavlov. Cond. index score0.20.30.9-0.0-0.0-0.00.10.9-0.8-0.1-0.70.9-0.0-0.20.0
Pavlov. Cond. latency score0.10.20.70.0-0.2-0.1-0.00.8-0.6-0.3-0.60.8-0.2-0.1-0.0
Pavlov. Cond. lever contacts0.40.50.90.9-0.8-0.9-0.80.3-0.1-0.9-0.10.3-0.80.6-0.9
Pavlov. Cond. magazine entry number0.10.10.5-0.20.20.20.1-0.70.60.20.5-0.60.20.00.2
Pavlov. Cond. intertrial magazine entries1.62.05.10.6-0.7-0.6-1.0-2.22.1-0.82.0-2.3-0.71.2-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.51.4-0.30.30.30.41.2-1.10.2-1.01.20.3-0.50.3
Pavlov. Cond. response bias0.10.20.40.3-0.3-0.4-0.20.6-0.5-0.4-0.50.5-0.30.1-0.3
Bone: apparent density9.816.319.0-4.34.14.44.23.5-3.74.2-3.73.54.1-4.24.3
Bone surface11.520.322.9-4.74.54.84.84.1-4.24.6-4.34.04.5-4.84.8
Bone volume9.415.917.5-4.13.94.14.13.9-3.93.9-4.03.83.9-4.24.1
Bone: connectivity density6.410.013.0-3.63.33.63.42.4-2.63.4-2.72.43.3-3.33.6
Bone: cortical apparent density0.20.20.40.6-0.6-0.5-0.6-0.20.3-0.60.3-0.3-0.60.6-0.5
Bone: cortical area8.112.214.4-3.83.63.83.73.0-3.13.6-3.22.93.6-3.73.8
Bone: cortical porosity0.30.30.60.8-0.7-0.8-0.6-0.10.1-0.60.2-0.0-0.70.5-0.8
Bone: cortical porosity0.60.61.01.0-0.9-1.0-0.8-0.30.4-0.90.4-0.3-0.90.8-1.0
Bone: cortical thickness2.54.15.3-2.22.12.32.21.6-1.72.1-1.71.62.1-2.12.3
Bone: cortical thickness0.10.10.3-0.20.10.30.1-0.60.50.10.5-0.50.10.00.3
Bone: cortical tissue density0.30.30.50.6-0.7-0.6-0.7-0.30.4-0.70.4-0.4-0.70.7-0.6
Bone: elastic displacement4.85.47.02.2-2.0-2.1-2.3-2.72.6-2.12.6-2.6-2.02.4-2.2
Bone: elastic work0.10.10.1-0.20.30.20.20.3-0.40.3-0.30.20.3-0.20.2
Bone: endosteal estimation8.017.219.0-4.34.24.24.33.8-4.04.2-4.03.94.2-4.44.2
Bone: endosteal perimeter6.613.515.3-3.83.73.73.93.4-3.53.7-3.63.63.7-3.93.7
Bone: final force10.717.619.1-4.14.24.14.34.1-4.24.2-4.34.24.2-4.44.1
Bone: final moment11.819.421.1-4.24.44.34.54.4-4.54.4-4.54.54.4-4.64.3
Bone: marrow area7.716.518.3-4.24.14.24.33.7-3.94.1-3.93.74.1-4.34.2
Bone: maximum diameter2.64.86.5-2.52.32.52.41.7-1.82.3-1.81.62.3-2.32.5
Bone: maximum force15.426.929.0-5.15.25.15.35.0-5.25.3-5.25.05.2-5.45.1
Bone: maximum moment16.629.031.3-5.35.45.35.55.3-5.45.5-5.45.35.4-5.65.3
Bone: minimum diameter9.016.618.4-4.24.14.14.33.8-4.04.1-4.03.94.1-4.34.1
Bone: periosteal estimation11.222.825.4-5.04.85.05.04.3-4.54.9-4.64.34.8-5.05.0
Bone: periosteal perimeter9.716.018.0-4.14.04.14.23.7-3.84.0-3.83.84.0-4.24.1
Bone: post-yield work9.212.513.8-3.53.63.53.73.3-3.53.7-3.53.33.6-3.73.5
Bone: stiffness18.529.331.4-5.45.35.35.55.5-5.55.3-5.65.45.3-5.65.3
Bone: tissue strength2.01.92.5-1.21.31.21.31.6-1.61.4-1.61.51.3-1.41.2
Bone: trabecular number6.19.512.1-3.43.23.53.32.5-2.63.2-2.72.53.2-3.23.4
Bone: trabecular spacing2.53.23.71.9-1.8-1.9-1.8-1.61.7-1.91.7-1.5-1.81.8-1.9
Bone: trabecular thickness0.20.30.90.3-0.2-0.3-0.10.9-0.8-0.2-0.80.9-0.2-0.0-0.3
Bone: trabecular tissue density0.20.20.70.2-0.2-0.20.00.8-0.7-0.2-0.60.9-0.2-0.1-0.2
Breakpoint value in progressive ratio session0.20.20.3-0.30.30.60.50.5-0.60.5-0.60.50.3-0.50.4
Distance traveled before self-admin1.41.52.41.1-1.3-1.0-1.3-1.11.1-1.01.1-1.6-1.31.3-1.1
Distance traveled after self-admin0.30.40.90.3-0.8-0.4-0.5-0.50.5-0.40.5-1.0-0.80.6-0.4
Delta time in closed arm before/after self-admin0.20.20.4-0.40.30.60.50.3-0.20.3-0.20.40.3-0.50.5
Delta time in open arm before/after self-admin4.64.45.22.0-1.9-2.1-2.1-2.32.2-2.02.2-2.2-1.92.1-2.1
Diff in mean of infusions in LGA sessions2.02.22.8-1.31.71.41.41.5-1.61.5-1.61.51.7-1.41.3
Extinction: sum of active levers before priming0.70.70.9-0.60.90.70.81.0-0.90.8-0.90.60.9-0.80.7
Active lever presses in extinction session 60.30.30.6-0.60.60.80.60.3-0.40.6-0.40.50.6-0.60.6
Delta distance traveled before/after self-admin0.10.10.2-0.40.00.20.30.2-0.10.2-0.10.10.0-0.30.3
Delta ambulatory time before/after self-admin0.00.00.1-0.2-0.30.00.10.1-0.0-0.0-0.00.0-0.3-0.10.0
Time in closed arm before self-admin1.31.51.8-1.31.01.21.31.0-1.21.4-1.21.21.0-1.31.2
Time in closed arm after self-admin0.60.61.1-0.90.41.00.90.7-0.70.8-0.71.00.4-0.90.9
Time in open arm before self-admin0.70.81.1-0.81.01.00.81.0-0.90.8-0.90.51.0-0.70.9
Time in open arm after self-admin0.20.20.40.6-0.1-0.6-0.5-0.30.3-0.40.3-0.6-0.10.5-0.6
Sum of active levers in priming session hrs 5-60.30.30.60.2-0.5-0.1-0.2-0.70.8-0.20.8-0.7-0.50.3-0.2
Time to tail flick, vehicle, before self-admin0.70.71.11.0-0.7-0.8-0.9-0.80.8-0.90.8-0.8-0.70.9-0.9
Time to tail flick, vehicle, after self-admin0.50.61.1-0.50.50.50.61.1-1.00.7-1.01.10.5-0.70.5
Time to tail flick, test, before self-admin0.10.10.40.5-0.1-0.6-0.4-0.00.0-0.2-0.0-0.1-0.10.4-0.6
Time to tail flick, test, after self-admin0.60.61.4-0.50.80.50.61.2-1.10.7-1.01.00.8-0.70.4
Delta time to tail flick, vehicle, before/after SA0.50.50.9-0.70.40.50.70.9-0.90.8-0.90.90.4-0.70.6
Delta time to tail flick, test, before/after SA0.20.20.4-0.40.20.40.50.6-0.50.3-0.40.70.2-0.50.4
Ambulatory time before self-admin3.84.04.62.1-2.0-2.0-2.1-1.91.9-1.91.9-2.1-2.02.1-2.0
Ambulatory time after self-admin2.42.63.61.4-1.9-1.4-1.5-1.51.6-1.51.6-1.8-1.91.5-1.4
Total heroin consumption1.72.02.3-1.41.21.51.51.4-1.41.5-1.41.41.2-1.51.4
Area under the delay curve1.11.22.1-0.91.10.81.01.2-1.21.0-1.21.41.1-1.11.0
Delay disc. indifference point, 0s delay1.31.51.8-1.21.11.01.31.3-1.31.2-1.21.41.1-1.31.1
Delay disc. indifference point, 16s delay1.01.02.4-0.90.70.80.91.2-1.10.9-1.11.50.7-1.00.8
Delay disc. indifference point, 2s delay2.02.23.1-1.31.81.21.41.5-1.51.4-1.51.51.8-1.41.4
Delay disc. indifference point, 24s delay1.11.01.2-1.10.91.11.10.9-0.91.1-0.91.10.9-1.11.1
Delay disc. indifference point, 4s delay0.60.61.4-0.50.80.40.71.0-1.00.7-1.01.20.8-0.80.6
Delay disc. indifference point, 8s delay2.32.42.8-1.61.61.51.51.5-1.51.6-1.51.71.6-1.51.5
Delay discount exponential model param1.11.22.00.9-1.1-0.8-1.0-1.21.2-1.01.2-1.4-1.11.0-0.9
Delay discount hyperbolic model param1.11.22.00.9-1.2-0.8-1.0-1.21.2-1.01.2-1.4-1.21.0-0.9
Fecal boli incidents, locomotor time 11.92.12.61.5-1.4-1.6-1.6-1.21.3-1.51.3-1.1-1.41.5-1.6
Change in fecal boli incidents, locomotor task1.21.11.7-1.31.21.21.20.8-0.81.2-0.90.51.2-1.11.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.40.20.40.2-0.30.20.30.2-0.30.2-0.10.4
Bouts of movement, locomotor time 10.00.00.0-0.20.10.00.10.00.00.00.00.10.1-0.1-0.1
Total resting periods, locomotor time 10.20.30.40.3-0.5-0.4-0.4-0.60.6-0.50.6-0.5-0.50.5-0.6
Rest time, locomotor task time 10.50.60.70.6-0.8-0.6-0.7-0.80.8-0.70.8-0.8-0.80.8-0.7
Distance moved, locomotor task time 10.00.00.1-0.20.20.30.2-0.10.10.20.1-0.10.2-0.10.3
Vertical activity count, locomotor time 11.31.31.9-1.21.41.11.20.9-1.01.2-1.10.91.4-1.21.2
Time >=10cm from walls, locomotor time 20.50.50.90.7-0.6-1.0-0.9-0.50.5-0.80.5-0.4-0.60.8-0.8
Bouts of movement, locomotor time 22.73.03.4-1.81.81.61.81.7-1.71.7-1.71.71.8-1.81.6
Total resting periods, locomotor time 23.13.33.8-1.91.81.71.91.8-1.81.8-1.81.81.8-2.01.7
Rest time, locomotor task time 20.10.10.4-0.1-0.00.20.0-0.40.4-0.10.4-0.6-0.00.10.1
Distance moved, locomotor task time 20.00.00.10.2-0.2-0.2-0.2-0.00.0-0.10.00.1-0.20.2-0.2
Vertical activity count, locomotor time 20.00.00.1-0.20.0-0.00.10.3-0.30.1-0.30.40.0-0.10.1
Weight adjusted by age1.51.72.2-1.51.41.41.31.1-1.21.5-1.20.91.4-1.21.4
Seeking ratio, delayed vs. immediate footshock0.20.20.4-0.60.30.60.60.3-0.40.6-0.40.50.3-0.70.5
Locomotion in novel chamber1.01.32.3-0.80.90.81.01.5-1.40.9-1.41.50.9-1.20.8
Locomotion in novel chamber post-restriction0.10.10.3-0.20.00.10.30.5-0.60.2-0.60.60.0-0.40.2
Progressive ratio0.30.41.10.1-0.3-0.1-0.5-1.00.9-0.30.9-1.0-0.30.6-0.2
Food seeking constrained by brief footshock0.70.82.00.7-0.4-0.7-0.9-1.21.0-0.71.0-1.4-0.41.0-0.8
Seeking ratio, punishment vs. effort0.10.10.20.20.2-0.10.10.5-0.4-0.1-0.40.30.2-0.1-0.1
Run reversals in cocaine runway, females0.20.20.60.10.3-0.10.20.6-0.50.1-0.50.80.3-0.3-0.1
Run reversals in cocaine runway, males1.71.71.91.2-1.4-1.2-1.2-1.41.3-1.31.3-1.2-1.41.2-1.2
Latency to leave start box in cocaine runway0.00.00.20.1-0.1-0.1-0.10.4-0.2-0.1-0.10.2-0.10.1-0.1
Latency to leave start box in cocaine runway, F1.41.62.21.3-1.3-1.4-1.5-0.81.0-1.31.0-1.0-1.31.5-1.3
Latency to leave start box in cocaine runway, M1.91.92.2-1.41.31.41.51.3-1.31.4-1.31.41.3-1.51.4
Cd content in liver0.80.91.00.9-1.0-0.9-0.9-0.90.9-1.00.9-0.8-1.00.9-0.9
Co content in liver0.80.91.21.1-1.1-1.1-1.1-0.50.6-1.00.6-0.7-1.11.0-1.1
Cu content in liver0.40.50.8-0.70.90.70.80.3-0.30.9-0.40.40.9-0.80.7
Fe content in liver0.60.70.80.8-0.7-0.8-0.8-0.80.9-0.70.9-0.9-0.70.9-0.8
K content in liver0.10.10.1-0.30.20.40.3-0.10.10.30.1-0.20.2-0.20.3
Mg content in liver0.10.10.30.1-0.3-0.1-0.3-0.50.5-0.30.5-0.4-0.30.3-0.1
Mn content in liver0.10.10.2-0.40.30.40.40.4-0.40.4-0.40.40.3-0.40.4
Na content in liver0.10.10.20.3-0.3-0.3-0.3-0.50.5-0.30.4-0.4-0.30.3-0.3
Rb content in liver1.21.53.00.8-0.9-0.8-1.0-1.71.7-0.91.6-1.6-0.91.1-0.8
Se content in liver1.41.73.20.9-1.2-0.9-1.2-1.81.7-1.21.7-1.6-1.21.2-0.9
Sr content in liver0.10.10.2-0.50.20.50.3-0.10.10.20.10.00.2-0.30.5
Zn content in liver2.62.93.41.6-1.6-1.6-1.7-1.71.8-1.71.8-1.8-1.61.8-1.6