Hub : Traits : body_g : ← →

chr10:81,874,092-84,687,108

Best TWAS P=2.716737e-08 · Best GWAS P=8.591201e-08 conditioned to 0.3621666

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Cdk12	alternative polyA	ENSRNOT00000114817	0.02	0.01	blup	908	0.02	4.4e-03	3.9	-5.2	2.0e-07	-0.77	0.38	0.45	FALSE
2	Adipose	Cdk12	gene expression	ENSRNOG00000006000	0.16	0.28	enet	75	0.29	1.5e-32	4.5	5.2	2.0e-07	0.86	0.44	0.56	FALSE
3	Adipose	Pcgf2	gene expression	ENSRNOG00000012705	0.02	0.02	top1	1	0.02	1.9e-03	5.2	-5.2	2.2e-07	-0.68	0.03	0.04	FALSE
4	Adipose	Stard3	gene expression	ENSRNOG00000042044	0.02	0.01	top1	1	0.01	1.4e-02	5.3	-5.3	1.5e-07	-0.81	0.03	0.04	FALSE
5	Adipose	Mllt6	gene expression	ENSRNOG00000053285	0.02	0.04	top1	1	0.04	5.7e-05	5.2	5.2	2.3e-07	0.68	0.03	0.04	FALSE
6	Adipose	Cdk12	isoform ratio	ENSRNOT00000114817	0.03	0.02	blup	908	0.04	8.8e-05	4.2	-5.2	2.0e-07	-0.79	0.45	0.54	FALSE
7	Adipose	Cdk12	intron excision ratio	chr10:83253382:83266506	0.02	0.01	blup	908	0.01	1.8e-02	4.1	5.4	8.7e-08	0.86	0.31	0.37	FALSE
8	Adipose	Cdk12	intron excision ratio	chr10:83271000:83279092	0.02	0.01	blup	908	0.02	2.6e-03	4.8	-5.5	3.9e-08	-0.85	0.41	0.48	FALSE
9	Adipose	NA	intron excision ratio	chr10:83271000:83279092	0.02	0.01	blup	907	0.02	2.8e-03	4.8	-5.5	3.7e-08	-0.86	0.40	0.49	FALSE
10	Adipose	Lasp1	mRNA stability	ENSRNOG00000004132	0.03	0.04	top1	1	0.04	5.4e-05	5.2	5.2	2.4e-07	0.69	0.08	0.11	FALSE
11	Adipose	Rpl19	mRNA stability	ENSRNOG00000004741	0.07	0.07	top1	1	0.07	2.0e-08	5.2	5.2	2.2e-07	0.71	0.39	0.60	FALSE
12	Adipose	Fbxl20	mRNA stability	ENSRNOG00000005081	0.04	0.03	blup	979	0.03	1.7e-04	4.2	5.3	1.4e-07	0.84	0.51	0.48	FALSE
13	Adipose	Cdk12	mRNA stability	ENSRNOG00000006000	0.05	0.07	blup	908	0.07	2.2e-08	4.7	5.2	2.1e-07	0.77	0.46	0.54	FALSE
14	BLA	Cacnb1	gene expression	ENSRNOG00000004518	0.13	0.00	blup	971	0.01	7.2e-02	5.3	5.2	1.9e-07	0.72	0.23	0.32	FALSE
15	BLA	Zpbp2	intron excision ratio	chr10:83560463:83563463	0.06	0.01	blup	1117	0.02	2.5e-02	5.2	-5.5	4.8e-08	-0.96	0.34	0.38	FALSE
16	BLA	Srcin1	intron excision ratio	chr10:82536884:82546225	0.06	0.04	top1	1	0.04	4.6e-03	5.1	5.1	3.2e-07	0.68	0.04	0.04	FALSE
17	BLA	Msl1	mRNA stability	ENSRNOG00000009643	0.25	0.10	blup	1470	0.12	4.1e-07	4.7	-5.2	1.5e-07	-0.92	0.55	0.45	FALSE
18	Brain	Lasp1	alternative polyA	ENSRNOT00000005522	0.08	0.07	enet	17	0.07	2.5e-07	5.2	-5.2	1.8e-07	-0.69	0.40	0.60	FALSE
19	Brain	Lasp1	alternative polyA	ENSRNOT00000102880	0.09	0.07	enet	16	0.07	3.8e-07	5.2	5.2	1.8e-07	0.69	0.39	0.61	FALSE
20	Brain	Cdk12	alternative polyA	ENSRNOT00000008256	0.04	0.03	blup	908	0.03	9.9e-04	4.8	-5.5	3.8e-08	-0.81	0.41	0.55	FALSE
21	Brain	Stac2	gene expression	ENSRNOG00000004805	0.07	0.07	blup	937	0.08	6.2e-08	5.3	-5.2	2.2e-07	-0.73	0.41	0.59	FALSE
22	Brain	Igfbp4	gene expression	ENSRNOG00000010635	0.23	0.17	top1	1	0.17	3.3e-15	5.2	5.2	1.6e-07	0.96	0.27	0.73	FALSE
23	Brain	Cisd3	gene expression	ENSRNOG00000036894	0.08	0.08	top1	1	0.08	1.3e-07	5.2	-5.2	1.9e-07	-0.68	0.32	0.66	FALSE
24	Brain	Stard3	gene expression	ENSRNOG00000042044	0.06	0.05	blup	887	0.07	4.1e-07	4.8	-5.4	7.3e-08	-0.85	0.44	0.56	FALSE
25	Brain	Cacnb1	isoform ratio	ENSRNOT00000082974	0.03	0.02	top1	1	0.02	8.5e-03	5.2	5.2	2.2e-07	0.70	0.04	0.04	FALSE
26	Brain	Cdk12	isoform ratio	ENSRNOT00000008256	0.04	0.04	top1	1	0.04	5.6e-05	5.1	-5.1	2.7e-07	-0.77	0.20	0.22	FALSE
27	Brain	Cdk12	isoform ratio	ENSRNOT00000082668	0.04	0.02	blup	908	0.03	1.6e-03	5.1	5.2	2.3e-07	0.71	0.42	0.56	FALSE
28	Brain	Cacnb1	intron excision ratio	chr10:83008403:83008770	0.04	0.02	blup	971	0.02	2.4e-03	5.3	5.1	3.2e-07	0.70	0.44	0.54	FALSE
29	Brain	Rpl19	intron excision ratio	chr10:83022773:83023579	0.10	0.04	blup	971	0.04	1.1e-04	5.2	-5.3	1.4e-07	-0.67	0.39	0.60	FALSE
30	Brain	Cdk12	intron excision ratio	chr10:83271000:83276800	0.08	0.05	top1	1	0.05	4.5e-05	5.2	5.2	1.8e-07	0.74	0.08	0.12	FALSE
31	Brain	Cdk12	intron excision ratio	chr10:83271000:83279092	0.09	0.12	top1	1	0.12	1.7e-11	5.2	-5.2	2.2e-07	-0.76	0.42	0.58	FALSE
32	Brain	Srcin1	intron excision ratio	chr10:82536884:82546225	0.07	0.07	lasso	28	0.07	8.4e-07	5.2	5.2	1.6e-07	0.69	0.31	0.69	FALSE
33	Brain	NA	intron excision ratio	chr10:83271000:83276800	0.08	0.05	top1	1	0.05	4.5e-05	5.2	5.2	1.8e-07	0.75	0.08	0.12	FALSE
34	Brain	NA	intron excision ratio	chr10:83271000:83279092	0.09	0.12	top1	1	0.12	1.7e-11	5.2	-5.2	2.2e-07	-0.77	0.41	0.58	FALSE
35	Brain	Mllt6	intron excision ratio	chr10:82666187:82667041	0.03	0.01	top1	1	0.01	2.1e-02	5.3	5.3	1.4e-07	0.68	0.03	0.04	FALSE
36	Brain	Lasp1	mRNA stability	ENSRNOG00000004132	0.07	0.06	top1	1	0.06	2.6e-06	5.2	5.2	1.9e-07	0.69	0.28	0.50	FALSE
37	Brain	Cacnb1	mRNA stability	ENSRNOG00000004518	0.08	0.06	blup	971	0.08	1.2e-07	5.0	-5.2	2.1e-07	-0.72	0.39	0.61	FALSE
38	Brain	Fbxl20	mRNA stability	ENSRNOG00000005081	0.05	0.05	blup	979	0.06	6.7e-06	5.3	-5.4	6.3e-08	-0.79	0.41	0.59	FALSE
39	Brain	Stard3	mRNA stability	ENSRNOG00000042044	0.08	0.09	blup	887	0.10	3.9e-09	5.2	-5.4	8.7e-08	-0.76	0.37	0.63	FALSE
40	LHb	NA	mRNA stability	ENSRNOG00000028430	0.37	0.11	top1	1	0.11	1.7e-03	5.2	-5.2	2.1e-07	-0.79	0.05	0.06	FALSE
41	Liver	Cdk12	isoform ratio	ENSRNOT00000008256	0.03	0.03	top1	1	0.03	5.6e-04	5.3	-5.3	1.4e-07	-0.78	0.07	0.14	FALSE
42	Liver	Cdk12	intron excision ratio	chr10:83271000:83276800	0.02	0.01	blup	908	0.01	1.8e-02	5.2	5.4	5.9e-08	0.83	0.31	0.38	FALSE
43	Liver	Zpbp2	intron excision ratio	chr10:83566539:83567063	0.03	0.02	top1	1	0.02	5.7e-03	5.2	5.2	1.7e-07	0.96	0.04	0.04	FALSE
44	Liver	NA	intron excision ratio	chr10:83271000:83276800	0.02	0.01	blup	907	0.01	1.7e-02	5.2	5.4	6.1e-08	0.84	0.31	0.38	FALSE
45	Liver	Zpbp2	mRNA stability	ENSRNOG00000007255	0.06	0.01	top1	1	0.01	2.3e-02	5.3	5.3	1.1e-07	0.99	0.05	0.08	FALSE
46	Liver	Srcin1	mRNA stability	ENSRNOG00000011475	0.02	0.02	top1	1	0.02	2.0e-03	5.2	5.2	1.9e-07	0.67	0.03	0.05	FALSE
47	Liver	NA	mRNA stability	ENSRNOG00000028430	0.07	0.06	lasso	16	0.08	1.3e-09	5.3	-5.6	2.7e-08	-0.89	0.43	0.57	TRUE
48	Liver	Ormdl3	mRNA stability	ENSRNOG00000030445	0.18	0.22	top1	1	0.22	1.4e-24	5.3	5.3	1.1e-07	0.96	0.24	0.76	FALSE
49	Liver	Stard3	mRNA stability	ENSRNOG00000042044	0.02	0.01	blup	887	0.02	5.8e-03	4.6	-5.1	3.0e-07	-0.79	0.40	0.43	FALSE
50	NAcc	Fbxl20	alternative TSS	ENSRNOT00000096966	0.17	0.09	enet	2	0.11	2.3e-03	5.2	-5.1	3.1e-07	-0.78	0.30	0.33	FALSE
51	NAcc	Psmb3	intron excision ratio	chr10:82697500:82697797	0.17	0.08	top1	1	0.08	6.5e-03	5.2	5.2	1.9e-07	0.68	0.05	0.06	FALSE
52	NAcc2	Cdk12	alternative polyA	ENSRNOT00000082668	0.12	0.04	top1	1	0.04	2.0e-03	5.1	5.1	3.0e-07	0.80	0.06	0.06	FALSE
53	NAcc2	Cdk12	alternative polyA	ENSRNOT00000105342	0.05	0.01	top1	1	0.01	6.3e-02	5.3	-5.3	1.3e-07	-0.77	0.04	0.05	FALSE
54	NAcc2	Tcap	gene expression	ENSRNOG00000068106	0.06	0.02	blup	901	0.03	7.8e-03	4.1	5.2	1.6e-07	0.84	0.36	0.38	FALSE
55	NAcc2	NA	gene expression	ENSRNOG00000070737	0.10	0.08	top1	1	0.08	6.7e-05	5.3	-5.3	1.1e-07	-0.70	0.09	0.21	FALSE
56	NAcc2	NA	isoform ratio	ENSRNOT00000101608	0.06	0.02	top1	1	0.02	1.7e-02	5.3	5.3	1.1e-07	0.70	0.04	0.05	FALSE
57	NAcc2	Cacnb1	mRNA stability	ENSRNOG00000004518	0.07	0.02	blup	971	0.04	3.3e-03	4.8	-5.1	2.8e-07	-0.71	0.38	0.50	FALSE
58	OFC	Msl1	intron excision ratio	chr10:83760232:83762620	0.15	0.10	lasso	4	0.11	1.1e-03	5.2	-5.2	1.7e-07	-0.97	0.41	0.31	FALSE
59	OFC	Srcin1	intron excision ratio	chr10:82530385:82530945	0.17	0.10	top1	1	0.10	2.8e-03	5.3	-5.3	1.4e-07	-0.67	0.05	0.08	FALSE
60	OFC	Srcin1	intron excision ratio	chr10:82530709:82530945	0.19	0.11	top1	1	0.11	1.8e-03	5.3	5.3	1.4e-07	0.67	0.06	0.09	FALSE
61	PL	Pip4k2b	gene expression	ENSRNOG00000013030	0.17	0.08	top1	1	0.07	7.6e-03	5.3	-5.3	1.4e-07	-0.68	0.06	0.06	FALSE
62	PL	Tcap	gene expression	ENSRNOG00000068106	0.26	0.11	top1	1	0.11	1.2e-03	5.2	5.2	1.9e-07	0.80	0.05	0.06	FALSE
63	PL	Rpl19	intron excision ratio	chr10:83018591:83023579	0.29	0.20	top1	1	0.20	1.8e-05	5.2	5.2	2.0e-07	0.71	0.06	0.07	FALSE
64	PL2	Cdk12	alternative polyA	ENSRNOT00000082668	0.06	0.02	blup	908	0.03	1.1e-02	4.2	5.1	3.1e-07	0.72	0.28	0.36	FALSE
65	PL2	Cacnb1	gene expression	ENSRNOG00000004518	0.07	0.03	blup	971	0.04	5.2e-03	5.3	5.1	3.2e-07	0.70	0.38	0.46	FALSE
66	PL2	Rpl19	gene expression	ENSRNOG00000004741	0.09	0.01	blup	971	0.01	9.7e-02	5.2	-5.2	2.3e-07	-0.71	0.30	0.44	FALSE
67	PL2	Stac2	gene expression	ENSRNOG00000004805	0.33	0.09	blup	937	0.12	8.3e-07	4.9	-5.2	1.9e-07	-0.76	0.44	0.56	FALSE
68	PL2	Srcin1	gene expression	ENSRNOG00000011475	0.05	0.02	top1	1	0.02	3.9e-02	5.1	5.1	3.3e-07	0.68	0.04	0.04	FALSE
69	PL2	Pcgf2	gene expression	ENSRNOG00000012705	0.05	0.03	top1	1	0.03	7.1e-03	5.2	-5.2	2.4e-07	-0.68	0.04	0.04	FALSE
70	PL2	Ormdl3	gene expression	ENSRNOG00000030445	0.11	0.03	blup	1118	0.04	1.8e-03	4.6	-5.4	6.2e-08	-0.94	0.50	0.44	FALSE
71	PL2	Tcap	gene expression	ENSRNOG00000068106	0.18	0.09	blup	901	0.10	7.6e-06	4.7	5.4	5.2e-08	0.73	0.38	0.62	FALSE
72	PL2	NA	gene expression	ENSRNOG00000070737	0.07	0.01	top1	1	0.01	1.2e-01	5.1	-5.1	3.2e-07	-0.70	0.04	0.04	FALSE
73	PL2	Msl1	mRNA stability	ENSRNOG00000009643	0.12	0.05	blup	1470	0.06	4.2e-04	4.9	-5.3	1.4e-07	-0.97	0.46	0.53	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.