Hub : Genes

Map2k7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000001047	0.03	0.02	6.5e-03	0.01	0.01	0.01	0	3.7e-02	3.7e-02	2.5e-02	9.2e-02
2	Brain	alternative polyA	ENSRNOT00000061821	0.03	0.02	1.4e-03	0.01	0.01	-0	0.01	3.8e-02	1.5e-02	5.8e-01	6.5e-02
3	Brain	alternative polyA	ENSRNOT00000104881	0.03	0.02	1.4e-03	0.01	0.02	0	0.01	2.4e-02	7.1e-03	3.2e-01	3.0e-02
4	PL	gene expression	ENSRNOG00000001047	0.03	0.02	5.9e-03	0.02	0.02	0.02	0.02	9.2e-03	6.5e-03	8.3e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.3	4.2	9.3	-3.0	1.6	-1.5	-1.7
BMI without tail	0.8	1.6	5.9	-2.4	0.1	-0.1	-0.7
Body weight	2.7	11.6	42.7	-6.5	0.1	0.1	-1.9
Epididymis fat weight	1.9	4.4	4.9	-2.0	2.1	-2.1	-2.2
Glucose	0.1	0.2	0.5	0.7	0.1	-0.1	0.5
Heart weight	0.7	1.0	1.6	0.8	-1.3	1.3	0.5
Left kidney weight	1.5	4.4	13.0	-3.6	-1.4	1.5	-0.5
Right kidney weight	1.2	3.4	9.8	-3.1	-1.3	1.4	-0.2
Tail length	1.4	4.1	13.9	-3.7	-0.9	1.0	-0.8
Length with tail	2.5	9.2	32.0	-5.7	-1.2	1.4	-1.2
Length without tail	2.3	4.9	17.1	-4.1	0.4	-0.3	-1.6
Liver weight, left	0.3	0.4	0.8	-0.3	-0.8	0.9	0.5
Liver weight, right	1.0	1.7	5.5	-2.4	0.1	-0.1	-1.1
Parametrial fat weight	0.9	1.7	2.4	1.1	-1.3	1.3	1.6
Retroperitoneal fat weight	2.1	6.9	10.8	-1.3	3.2	-3.3	-2.2
Intraocular pressure	1.3	1.8	4.2	-2.0	0.7	-0.7	-1.4
Extensor digitorum longus weight	2.0	8.1	23.1	-4.8	1.1	-1.0	-2.7
Soleus weight	1.1	3.3	7.7	-2.8	1.0	-1.0	-1.8
Tibialis anterior weight	2.5	8.5	24.7	-5.0	1.2	-1.0	-2.6
Tibia length	1.3	3.7	6.0	-0.5	-2.4	2.5	1.7
Number of licking bursts	7.6	9.0	11.0	2.3	-3.3	3.3	3.0
Food consumed during 24 hour testing period	0.8	1.0	1.4	0.6	-1.2	1.2	0.9
Times rat made contact with spout	0.6	0.7	1.3	-0.0	-1.1	1.1	0.5
Mean time between licks in bursts	0.2	0.2	0.7	0.8	0.3	-0.3	0.1
Mean num. licks in bursts	2.6	3.1	3.4	-1.7	1.8	-1.8	-1.8
Std. dev. time between licks in bursts	0.4	0.5	0.9	-0.9	0.4	-0.4	-0.9
Water consumed over 24 hours	1.9	2.2	3.9	0.0	-1.9	2.0	1.1
Indifference point 0 sec	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Indifference point AUC	0.1	0.2	0.3	-0.3	-0.5	0.5	0.1
Indifference point function ln k	0.2	0.2	0.4	0.1	-0.6	0.7	0.2
Indifference point function log k	0.2	0.2	0.4	0.1	-0.6	0.7	0.2
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1
Delay discounting total patch changes 12 sec	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.3
Delay discounting total patch changes 18 sec	0.2	0.3	0.4	0.4	-0.7	0.7	0.5
Delay discounting total patch changes 24 sec	0.2	0.3	0.7	-0.5	0.4	-0.4	-0.8
Delay discounting total patch changes 6 sec	0.1	0.1	0.3	-0.6	0.0	-0.0	-0.4
Delay discounting time to switch 0 sec	0.5	0.8	1.2	1.1	0.9	-1.0	0.5
Delay discounting water rate 0 sec	0.7	1.2	2.1	-1.4	-1.0	1.1	-0.4
Delay discounting water rate 12 sec	0.2	0.3	0.5	-0.7	-0.1	0.2	-0.7
Delay discounting water rate 18 sec	0.3	0.4	1.0	-0.5	0.4	-0.4	-1.0
Delay discounting water rate 24 sec	0.5	0.7	1.7	-1.3	-0.6	0.6	-0.6
Delay discounting water rate 6 sec	1.1	1.6	3.0	-1.7	0.8	-0.7	-1.5
Locomotor activity	0.5	0.9	2.6	-1.6	-0.4	0.4	-0.7
Locomotor testing distance	0.3	0.4	0.7	-0.8	-0.7	0.7	-0.0
Locomotor testing rearing	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.2
Light reinforcement 1	0.3	0.5	0.9	0.4	0.9	-0.9	-0.5
Light reinforcement 2	0.7	0.9	1.5	1.2	-0.8	0.8	1.0
Reaction time number correct	0.3	0.4	0.7	-0.2	-0.8	0.8	0.2
Reaction time mean minus median	3.8	5.0	6.1	-2.3	2.1	-2.1	-2.5
Reaction time mean minus median AUC	1.4	1.7	2.6	-1.0	1.3	-1.3	-1.6
Reaction time num false alarms	0.8	1.1	1.7	-0.8	1.0	-1.0	-1.3
Reaction time num false alarms AUC	1.6	2.2	3.1	-1.3	1.4	-1.4	-1.7
Reaction time trials correct on left	0.3	0.4	0.7	-0.2	-0.8	0.8	0.2
Reaction time trials on left	0.2	0.3	0.7	-0.2	-0.8	0.8	0.2
Reaction time mean	0.5	0.7	1.2	0.7	1.1	-1.1	-0.3
Reaction time mean AUC	0.7	0.9	1.6	0.6	1.2	-1.3	-0.5
Median of all reaction times	0.7	0.9	2.6	1.6	0.7	-0.8	0.4
Reaction time omissions	0.7	0.9	1.3	-0.2	1.1	-1.1	-1.0
Reaction time false alarm rate	1.8	2.6	3.2	-1.2	1.7	-1.7	-1.8
Reaction time premature initiation rate	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.4
Reaction time premature initiations	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.2
Std. dev. reaction times	1.6	2.2	2.7	-1.0	1.6	-1.7	-1.5
Reaction time trials completed	0.2	0.3	0.7	-0.2	-0.8	0.8	0.2
Reaction time trials AUC	0.1	0.2	0.3	-0.3	-0.6	0.6	0.0
Social response proportion	0.5	0.6	0.9	-0.8	-0.9	0.9	0.2
Social responses	0.8	1.0	2.9	-1.7	0.1	-0.1	-1.0
Social time	0.5	0.7	2.6	1.6	-0.0	-0.0	0.5
Conditioned locomotion	0.8	0.9	0.9	-0.9	1.0	-1.0	-1.0
Cocaine response after cond. corrected	0.1	0.1	0.3	0.3	0.1	-0.1	0.5
Cocaine response after cond. not corrected	0.9	1.0	1.5	-0.8	1.2	-1.2	-0.7
Cocaine response before conditioning	4.7	5.8	7.1	-2.4	2.3	-2.2	-2.7
Saline control response	1.2	1.6	3.0	-0.2	-1.7	1.7	0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.7	-0.2	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.5	0.5	0.2
Condit. Reinf. active responses	1.0	1.4	2.7	-1.6	0.8	-0.7	-1.3
Condit. Reinf. inactive responses	1.2	1.6	2.3	-1.5	1.0	-1.0	-1.4
Condit. Reinf. lever presses	2.1	2.9	3.7	-1.9	1.5	-1.5	-1.9
Condit. Reinf. lever reinforcers received	0.8	1.1	1.9	-1.4	0.7	-0.7	-1.2
Pavlov. Cond. lever latency	1.3	1.8	2.2	1.1	-1.4	1.4	1.5
Pavlov. Cond. magazine entry latency	1.5	1.7	2.7	-0.4	1.6	-1.6	-1.2
Pavlov. Cond. change in total contacts	0.4	0.6	0.8	-0.6	0.7	-0.7	-0.9
Pavlov. Cond. index score	1.4	1.8	2.3	-0.7	1.5	-1.5	-1.4
Pavlov. Cond. latency score	1.5	1.9	2.5	-0.7	1.6	-1.6	-1.4
Pavlov. Cond. lever contacts	2.5	3.5	4.0	-1.5	2.0	-2.0	-2.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.6	0.0	-1.2	1.2	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	-0.0	-0.9	1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.5	2.0	-0.5	1.4	-1.4	-1.3
Pavlov. Cond. response bias	3.2	4.3	5.2	-1.4	2.3	-2.3	-2.2
Conditioned reinforcement - actives	1.2	1.1	1.8	-1.0	-1.3	1.3	0.4
Conditioned reinforcement - inactives	1.0	1.1	1.6	0.6	-1.3	1.3	1.0
Conditioned locomotion	0.8	0.9	3.0	-1.7	-0.1	0.2	-0.8
Intermittent access intake day 1-15 change	1.2	1.2	2.0	-0.0	-1.4	1.4	0.9
Intermittent access intake escalation	0.6	0.6	1.0	-0.5	-1.0	1.0	0.4
Intermittent access intake escalation 2	0.1	0.1	0.2	0.0	-0.5	0.5	0.2
Intermitt. access day 1 inactive lever presses	1.1	1.2	1.8	0.7	-1.3	1.3	0.9
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.7	0.6	-0.4	0.3	0.8
Intermitt. access escalation Index	0.5	0.4	0.8	-0.4	0.6	-0.6	-0.9
Intermittent access day 1 total infusions	0.4	0.5	0.7	0.0	0.8	-0.9	-0.7
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.5	0.0	0.0	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Intermittent access total infusions	0.4	0.4	0.6	-0.2	0.8	-0.8	-0.6
Intermittent access day 1 locomotion	2.9	3.0	4.1	-0.7	2.0	-2.0	-1.8
Intermittent access day 15 total locomotion	1.5	1.6	2.8	-1.2	1.1	-1.0	-1.7
Intermittent access total locomotion	1.8	2.1	2.9	-0.7	1.6	-1.6	-1.7
Intermittent access standard deviation	0.5	0.6	0.8	0.2	-0.8	0.8	0.9
Cocaine induced anxiety	3.0	3.4	4.0	-1.3	2.0	-2.0	-2.0
Post-drug Anxiety	1.8	2.0	3.6	0.4	1.8	-1.9	-1.0
Baseline Anxiety	1.0	1.1	3.3	1.8	0.2	-0.3	0.9
Lifetime Intake	0.2	0.2	0.4	0.1	0.6	-0.6	-0.2
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.1	0.1	-0.1	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	0.1	-0.7	0.7	0.5
Progressive ratio test 1 breakpoint	0.5	0.5	0.8	0.2	-0.9	0.9	0.7
Progressive ratio test 1 inactive lever presses	1.0	1.0	1.8	0.3	-1.3	1.4	0.7
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	-0.6	-0.5	0.5	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.2	-0.6	0.6	0.1
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.5	-1.0	-1.2	1.2	-0.0
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.2
Short access day 1 total inactive lever presses	0.8	0.9	1.2	0.7	-1.1	1.1	0.9
Short access day 10 total inactive lever presses	0.7	0.7	1.2	-0.5	-1.1	1.1	0.6
Short access day 1 total infusions	0.4	0.4	1.1	1.0	0.2	-0.2	0.7
Short access day 10 total infusions	0.4	0.5	0.8	0.2	0.9	-0.9	-0.4
Short access total infusions	0.3	0.3	0.7	0.8	0.1	-0.2	0.7
Short access day 1 locomotion	0.3	0.3	0.4	0.5	0.6	-0.6	-0.3
Short access day 10 total locomotion	0.3	0.3	0.5	-0.0	0.7	-0.7	-0.6
Short access total locomotion	0.7	0.7	1.3	0.2	1.1	-1.1	-0.6
Compulsive drug intake	1.2	1.2	4.1	2.0	-0.3	0.2	0.8
One hour access (0.3 mA shock)	0.6	0.7	1.3	0.6	-1.1	1.1	0.4
One hour access (shock baseline)	0.5	0.6	1.7	-1.3	-0.1	0.1	-0.8
Number of responses in last shaping day	0.1	0.1	0.2	0.1	-0.4	0.4	0.3
Context. condit. distance diff. score	4.8	5.9	11.1	-3.3	1.8	-1.7	-2.5
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	0.5	-0.5	-0.3
Locomotion distance, session 1	0.1	0.2	0.5	0.7	0.2	-0.2	0.1
Locomotion velocity, session 2	0.5	0.6	0.7	0.8	-0.7	0.7	0.8
Locomotion distance, session 2	0.4	0.5	1.3	1.1	-0.5	0.5	0.5
Locomotion velocity, session 3	1.2	1.4	2.1	-1.4	1.0	-1.0	-1.2
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.2	-0.2	-0.4
Stereotopy head waving bouts, day 3	0.4	0.5	1.6	-1.3	-0.4	0.4	-0.2
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.0	-0.1	0.1	0.2
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	0.2	-0.2	0.1
Locomotion distance, session 7	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.4
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	-0.0	0.5	-0.5	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.5	0.1	-0.1	0.2
Locomotion velocity, session 8	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1
Locomotion distance, session 8	0.8	1.1	2.5	-1.6	0.7	-0.6	-1.1
Degree of sensitization distance	0.4	0.4	1.2	1.1	-0.3	0.3	0.6
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.1	0.6	-0.6	-0.4
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.0	1.0	-1.0	-0.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.2	-0.5	1.1	-1.1	-0.8
Condit. Reinf. active responses	0.6	0.8	1.0	-0.3	1.0	-1.0	-0.9
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.0	0.5	-0.5	-0.7
Incentive salience index mean	1.1	1.3	1.8	-0.5	1.3	-1.3	-1.2
Condit. Reinf. lever presses	1.5	2.0	2.5	-0.9	1.5	-1.5	-1.6
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.7	-0.4	0.4	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.3
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.5	0.7	-0.8	-0.5
Total locomotion distance, hab. session 1	1.3	1.9	2.9	-0.5	1.7	-1.7	-1.3
Locomotion velocity, hab. session 1	1.3	1.9	3.0	-0.1	1.7	-1.7	-1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.1	0.4	-0.4	-0.1
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	0.0	-0.0	-0.1
Total zone transitions, hab. session 2	0.8	1.0	1.3	0.7	-1.1	1.1	1.0
Total locomotion distance, hab. session 2	0.0	0.1	0.2	0.4	-0.1	0.1	0.2
Locomotion velocity, hab. session 2	0.1	0.2	0.4	0.6	-0.3	0.3	0.4
Novel to familiar place preference ratio	0.9	0.9	1.0	0.9	-1.0	1.0	1.0
Novelty place preference	0.9	0.9	1.1	1.0	-0.9	0.9	1.0
Time in novel zone, NPP test	0.7	0.7	0.8	0.8	-0.8	0.8	0.9
Total zone transitions, NPP test	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.2
Total locomotion distance, NPP test	1.7	2.4	2.7	-1.3	1.6	-1.6	-1.6
Locomotion velocity, NPP test	1.3	1.8	2.4	-1.2	1.3	-1.3	-1.5
Pavlov. Cond. lever latency	0.7	0.9	1.6	-0.5	-1.2	1.3	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.6	0.0	-0.0	-0.3
Pavlov. Cond. change in total contacts	0.7	0.8	1.3	-0.2	1.1	-1.1	-0.7
Pavlov. Cond. index score	0.6	0.8	1.0	-0.6	1.0	-1.0	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.2	-0.5	1.1	-1.1	-1.0
Pavlov. Cond. lever contacts	0.8	1.0	1.6	0.2	1.2	-1.3	-0.8
Pavlov. Cond. magazine entry number	0.8	1.0	1.7	1.3	-0.7	0.6	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	1.0	-0.3	0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.9	-0.6	0.9	-0.9	-0.9
Pavlov. Cond. response bias	0.8	1.0	1.3	-1.0	0.9	-0.9	-1.1
Bone: apparent density	2.1	3.4	10.0	-3.2	0.8	-0.7	-1.6
Bone surface	2.1	3.7	11.0	-3.3	0.9	-0.8	-1.6
Bone volume	2.6	4.3	9.9	-3.2	1.4	-1.3	-1.9
Bone: connectivity density	1.9	2.9	10.0	-3.2	0.3	-0.2	-1.3
Bone: cortical apparent density	0.1	0.1	0.2	0.4	0.4	-0.4	0.1
Bone: cortical area	1.6	2.5	5.6	-2.4	1.0	-1.0	-1.4
Bone: cortical porosity	0.1	0.1	0.1	-0.0	-0.3	0.3	0.2
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3
Bone: cortical thickness	0.9	1.4	3.6	-1.9	0.7	-0.7	-1.0
Bone: cortical thickness	0.2	0.2	0.6	-0.8	-0.3	0.4	-0.2
Bone: cortical tissue density	0.1	0.1	0.2	0.5	0.3	-0.4	0.2
Bone: elastic displacement	0.2	0.2	0.3	-0.4	-0.5	0.5	0.1
Bone: elastic work	0.9	1.2	4.0	-2.0	-0.3	0.3	-0.7
Bone: endosteal estimation	0.3	0.6	0.9	-0.7	-0.9	0.9	0.2
Bone: endosteal perimeter	0.8	1.7	4.2	-2.0	0.6	-0.5	-1.4
Bone: final force	0.4	0.7	1.4	-1.2	-0.8	0.8	0.2
Bone: final moment	0.4	0.7	0.9	-0.9	-0.9	0.9	0.3
Bone: marrow area	0.3	0.6	1.0	-0.7	-1.0	1.0	0.2
Bone: maximum diameter	0.7	1.2	3.8	-2.0	0.4	-0.3	-0.9
Bone: maximum force	0.5	0.9	3.0	-1.7	-0.3	0.3	-0.5
Bone: maximum moment	0.4	0.6	2.1	-1.4	-0.4	0.5	-0.3
Bone: minimum diameter	0.0	0.1	0.1	0.1	-0.3	0.3	0.3
Bone: periosteal estimation	0.5	0.9	3.3	-1.8	-0.1	0.2	-0.6
Bone: periosteal perimeter	2.3	3.8	6.6	-2.6	1.5	-1.4	-2.1
Bone: post-yield work	1.1	1.5	1.9	-1.4	1.1	-1.0	-1.3
Bone: stiffness	0.3	0.5	1.5	-1.2	0.2	-0.2	-0.7
Bone: tissue strength	0.6	0.6	0.7	0.6	-0.8	0.8	0.9
Bone: trabecular number	1.4	2.2	7.3	-2.7	0.5	-0.4	-1.1
Bone: trabecular spacing	0.8	1.0	3.6	1.9	0.1	-0.1	0.5
Bone: trabecular thickness	4.0	4.8	11.5	-3.4	1.3	-1.3	-2.1
Bone: trabecular tissue density	1.3	1.8	2.0	-1.2	1.4	-1.4	-1.4
Breakpoint value in progressive ratio session	2.5	2.8	3.1	-1.8	1.6	-1.6	-1.8
Distance traveled before self-admin	0.3	0.4	0.6	0.1	0.8	-0.8	-0.6
Distance traveled after self-admin	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.2
Delta time in open arm before/after self-admin	0.9	0.8	1.4	0.6	1.1	-1.2	-0.4
Diff in mean of infusions in LGA sessions	1.1	1.2	1.6	-1.2	1.0	-0.9	-1.3
Extinction: sum of active levers before priming	1.1	1.1	1.8	-0.1	1.3	-1.3	-0.9
Active lever presses in extinction session 6	0.5	0.5	0.8	-0.9	0.6	-0.6	-0.7
Delta distance traveled before/after self-admin	0.4	0.5	0.7	0.2	-0.8	0.8	0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.3	-0.4	0.4	0.3
Time in closed arm before self-admin	0.7	0.8	1.3	-0.2	-1.1	1.2	0.7
Time in closed arm after self-admin	0.4	0.5	0.9	-0.3	-0.9	1.0	0.0
Time in open arm before self-admin	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.0
Time in open arm after self-admin	0.2	0.3	0.5	-0.2	0.7	-0.7	-0.3
Sum of active levers in priming session hrs 5-6	1.7	1.7	2.8	-0.7	1.6	-1.7	-0.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	0.8	0.4	-0.4	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.2	-0.6	0.7	0.4
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.1	0.5	-0.6	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.0	0.3	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.7	0.7	1.1	-0.3	1.0	-1.0	-0.6
Ambulatory time before self-admin	2.1	2.2	2.7	-1.0	1.6	-1.6	-1.6
Ambulatory time after self-admin	0.9	1.0	1.1	-0.9	1.0	-1.0	-1.1
Total heroin consumption	3.0	3.6	5.5	-0.4	2.3	-2.3	-1.9
Area under the delay curve	0.8	0.8	1.4	-0.1	1.2	-1.2	-0.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.1	0.5	-0.5	0.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	0.4	-0.4	-0.1
Delay disc. indifference point, 2s delay	3.3	3.7	5.8	-0.7	2.4	-2.4	-1.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	0.9	-0.1	0.1	0.4
Delay disc. indifference point, 4s delay	1.9	2.0	3.1	-0.5	1.7	-1.8	-1.2
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	-0.1	0.8	-0.8	-0.6
Delay discount exponential model param	1.1	1.2	1.9	0.2	-1.4	1.4	1.0
Delay discount hyperbolic model param	1.1	1.2	2.0	0.2	-1.4	1.4	0.9
Fecal boli incidents, locomotor time 1	0.5	0.5	1.6	-1.3	-0.1	0.1	-0.7
Change in fecal boli incidents, locomotor task	0.7	0.7	1.3	1.1	-0.5	0.4	1.1
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.7	-0.5	1.6	-1.7	-1.2
Bouts of movement, locomotor time 1	0.3	0.3	0.8	-0.9	-0.5	0.6	-0.1
Total resting periods, locomotor time 1	0.3	0.3	0.9	-0.9	-0.4	0.4	-0.2
Rest time, locomotor task time 1	0.5	0.6	1.7	-1.3	0.2	-0.2	-0.6
Distance moved, locomotor task time 1	0.2	0.2	0.8	0.9	-0.1	0.1	0.3
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	0.4	0.2
Time >=10cm from walls, locomotor time 2	2.5	2.6	3.7	-1.9	1.5	-1.5	-1.5
Bouts of movement, locomotor time 2	1.2	1.3	3.2	-1.8	0.6	-0.5	-1.2
Total resting periods, locomotor time 2	1.0	1.0	2.9	-1.7	0.4	-0.4	-1.0
Rest time, locomotor task time 2	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.8
Distance moved, locomotor task time 2	2.1	2.4	2.6	1.4	-1.6	1.6	1.6
Vertical activity count, locomotor time 2	1.9	2.1	3.4	0.4	-1.8	1.8	1.2
Weight adjusted by age	0.3	0.4	0.6	-0.4	-0.7	0.8	0.4
Seeking ratio, delayed vs. immediate footshock	3.2	3.7	7.8	2.8	-1.3	1.3	1.9
Locomotion in novel chamber	0.4	0.5	1.0	0.2	-1.0	1.0	0.3
Locomotion in novel chamber post-restriction	0.5	0.6	1.5	-1.2	-0.5	0.5	-0.6
Progressive ratio	0.7	0.8	1.7	1.3	-0.6	0.6	1.0
Food seeking constrained by brief footshock	0.3	0.4	1.0	1.0	-0.3	0.3	0.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.7	-0.9	0.3	-0.2	-0.5
Run reversals in cocaine runway, females	0.2	0.2	0.3	0.0	0.5	-0.5	-0.3
Run reversals in cocaine runway, males	0.7	0.7	1.0	0.7	-1.0	1.0	0.6
Latency to leave start box in cocaine runway	0.2	0.3	0.5	0.6	-0.4	0.3	0.7
Latency to leave start box in cocaine runway, F	0.8	0.9	1.6	0.7	-0.9	0.9	1.3
Latency to leave start box in cocaine runway, M	0.6	0.5	0.9	-0.3	0.8	-0.8	-1.0
Cd content in liver	0.9	1.0	2.5	1.6	-0.8	0.8	0.6
Co content in liver	1.5	1.8	2.5	0.9	-1.6	1.6	1.2
Cu content in liver	0.3	0.3	0.6	-0.4	0.5	-0.5	-0.8
Fe content in liver	5.1	6.1	9.4	-3.1	2.0	-1.9	-2.7
K content in liver	0.5	0.5	0.6	-0.5	0.8	-0.8	-0.7
Mg content in liver	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1
Mn content in liver	1.4	1.6	2.4	1.5	-1.1	1.0	1.4
Na content in liver	0.3	0.4	0.6	-0.8	0.5	-0.5	-0.6
Rb content in liver	1.3	1.7	2.8	0.1	1.6	-1.7	-1.1
Se content in liver	6.5	7.9	8.1	-2.8	2.8	-2.8	-2.8
Sr content in liver	2.2	2.1	2.5	0.9	-1.5	1.5	1.6
Zn content in liver	0.5	0.6	0.9	-0.6	-0.9	0.9	0.4