Hub : Genes

Tmie

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000027799 0.74 0.11 0.0e+00 0.01 0.2 0.2 0.2 2.0e-02 2.4e-22 2.5e-22 1.7e-21
2 Liver mRNA stability ENSRNOG00000027799 0.11 0.09 7.2e-04 0.02 0.02 0.02 0.02 9.5e-04 4.2e-03 4.0e-03 2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail1.44.47.0-2.6-1.4
BMI without tail1.53.24.9-1.2-2.2
Body weight3.615.030.00.1-5.5
Epididymis fat weight0.20.50.80.4-0.9
Glucose0.20.30.6-0.3-0.8
Heart weight1.21.73.40.4-1.8
Left kidney weight0.92.72.8-1.7-1.6
Right kidney weight0.51.42.0-1.4-0.9
Tail length4.614.022.72.3-4.8
Length with tail5.921.737.02.5-6.1
Length without tail3.78.013.81.5-3.7
Liver weight, left0.40.61.11.1-0.2
Liver weight, right0.81.32.60.2-1.6
Parametrial fat weight0.71.32.60.2-1.6
Retroperitoneal fat weight0.41.22.40.1-1.5
Intraocular pressure2.23.15.22.3-1.0
Extensor digitorum longus weight0.10.50.8-0.50.9
Soleus weight2.06.011.90.2-3.5
Tibialis anterior weight0.00.10.1-0.4-0.1
Tibia length3.911.121.6-0.7-4.7
Number of licking bursts0.20.20.40.20.6
Food consumed during 24 hour testing period0.60.71.40.1-1.2
Times rat made contact with spout0.40.40.50.6-0.7
Mean time between licks in bursts0.91.31.8-0.91.3
Mean num. licks in bursts0.40.51.00.2-1.0
Std. dev. time between licks in bursts3.13.65.7-1.32.4
Water consumed over 24 hours0.10.10.2-0.50.1
Indifference point 0 sec0.71.11.30.9-1.1
Indifference point AUC0.10.10.2-0.2-0.4
Indifference point function ln k1.01.42.5-1.60.4
Indifference point function log k1.01.42.5-1.60.4
Delay discounting total patch changes 0 sec0.81.21.51.0-1.2
Delay discounting total patch changes 12 sec0.70.91.10.8-1.1
Delay discounting total patch changes 18 sec2.22.93.41.9-1.6
Delay discounting total patch changes 24 sec1.51.93.40.6-1.9
Delay discounting total patch changes 6 sec0.10.20.30.5-0.4
Delay discounting time to switch 0 sec0.10.20.30.40.5
Delay discounting water rate 0 sec0.10.10.20.0-0.4
Delay discounting water rate 12 sec0.20.30.5-0.4-0.7
Delay discounting water rate 18 sec0.81.12.1-1.4-0.3
Delay discounting water rate 24 sec0.50.71.10.5-1.1
Delay discounting water rate 6 sec0.40.50.5-0.7-0.7
Locomotor activity3.45.49.61.1-3.1
Locomotor testing distance3.15.19.60.8-3.1
Locomotor testing rearing0.30.40.70.8-0.4
Light reinforcement 10.30.61.2-0.1-1.1
Light reinforcement 20.70.91.9-1.40.1
Reaction time number correct0.20.30.50.10.7
Reaction time mean minus median0.20.20.4-0.6-0.3
Reaction time mean minus median AUC0.10.10.3-0.2-0.5
Reaction time num false alarms0.30.40.70.40.8
Reaction time num false alarms AUC0.20.30.30.60.4
Reaction time trials correct on left0.20.30.50.10.7
Reaction time trials on left0.20.30.50.20.7
Reaction time mean0.10.10.10.4-0.1
Reaction time mean AUC0.10.10.10.40.0
Median of all reaction times0.20.20.50.7-0.0
Reaction time omissions0.91.21.91.40.7
Reaction time false alarm rate0.10.10.20.40.3
Reaction time premature initiation rate1.31.82.90.8-1.7
Reaction time premature initiations0.60.91.40.6-1.2
Std. dev. reaction times0.10.10.10.2-0.3
Reaction time trials completed0.20.30.50.20.7
Reaction time trials AUC0.20.40.70.10.8
Social response proportion0.70.81.01.0-0.8
Social responses0.30.40.70.0-0.8
Social time0.30.30.4-0.60.5
Conditioned locomotion1.61.93.8-0.12.0
Cocaine response after cond. corrected0.20.20.30.5-0.4
Cocaine response after cond. not corrected0.91.11.90.5-1.4
Cocaine response before conditioning1.01.21.9-0.7-1.4
Saline control response1.31.71.71.3-1.3
Condit. Reinf. active minus inactive responses1.11.42.7-0.1-1.6
Condit. Reinf. active-inactive response ratio1.01.02.0-0.3-1.4
Condit. Reinf. active responses1.01.32.50.4-1.6
Condit. Reinf. inactive responses0.10.10.10.40.2
Condit. Reinf. lever presses1.31.83.5-0.3-1.9
Condit. Reinf. lever reinforcers received1.01.42.70.4-1.6
Pavlov. Cond. lever latency0.40.60.60.70.8
Pavlov. Cond. magazine entry latency1.21.32.6-1.60.2
Pavlov. Cond. change in total contacts1.21.73.3-0.3-1.8
Pavlov. Cond. index score0.71.01.8-1.3-0.4
Pavlov. Cond. latency score0.81.01.9-1.4-0.4
Pavlov. Cond. lever contacts0.70.91.5-0.7-1.2
Pavlov. Cond. magazine entry number1.01.22.11.5-0.6
Pavlov. Cond. intertrial magazine entries0.91.21.51.20.9
Pavlov. Cond. lever-magazine prob. diff.0.91.22.3-1.5-0.4
Pavlov. Cond. response bias0.71.01.9-1.4-0.3
Conditioned reinforcement - actives0.40.40.7-0.40.8
Conditioned reinforcement - inactives0.50.61.0-0.51.0
Conditioned locomotion0.40.50.8-0.40.9
Intermittent access intake day 1-15 change0.40.40.8-0.20.9
Intermittent access intake escalation0.30.30.7-0.20.8
Intermittent access intake escalation 20.00.00.00.1-0.1
Intermitt. access day 1 inactive lever presses0.10.10.1-0.30.0
Intermitt. access day 15 inactive lever presses0.40.40.6-0.50.8
Intermitt. access escalation Index0.00.00.0-0.1-0.1
Intermittent access day 1 total infusions0.00.00.0-0.20.2
Intermittent access day 15 total infusions0.30.30.6-0.30.8
Intermittent access terminal intake (last 3 days)0.20.20.3-0.20.6
Intermittent access total infusions0.50.50.8-0.50.9
Intermittent access day 1 locomotion0.10.10.1-0.30.4
Intermittent access day 15 total locomotion0.40.40.7-0.30.9
Intermittent access total locomotion0.91.01.6-0.61.3
Intermittent access standard deviation0.10.10.10.2-0.3
Cocaine induced anxiety0.30.30.5-0.30.7
Post-drug Anxiety0.10.10.2-0.10.4
Baseline Anxiety0.10.10.2-0.20.4
Lifetime Intake0.40.40.7-0.40.8
Incentive Sensitization - Responses1.01.01.6-0.71.3
Incentive Sensitization - Breakpoint1.01.01.6-0.61.3
Progressive ratio test 1 active lever presses0.00.00.0-0.10.1
Progressive ratio test 1 breakpoint0.00.00.0-0.10.2
Progressive ratio test 1 inactive lever presses0.30.30.6-0.30.8
Progressive ratio test 2 active lever presses0.70.71.2-0.51.1
Progressive ratio test 2 breakpoint0.60.61.1-0.51.0
Progressive ratio test 2 inactive lever presses1.71.93.0-0.91.7
Total sessions with >9 infusions0.10.10.3-0.00.5
Short access day 1 total inactive lever presses2.93.35.2-1.12.3
Short access day 10 total inactive lever presses0.00.00.0-0.20.2
Short access day 1 total infusions0.70.71.3-0.41.1
Short access day 10 total infusions0.10.10.2-0.30.4
Short access total infusions0.50.50.9-0.40.9
Short access day 1 locomotion0.10.10.2-0.20.5
Short access day 10 total locomotion0.00.00.00.1-0.0
Short access total locomotion0.10.10.1-0.10.3
Compulsive drug intake0.00.00.0-0.10.0
One hour access (0.3 mA shock)0.20.20.3-0.30.5
One hour access (shock baseline)0.10.10.1-0.30.4
Number of responses in last shaping day0.70.71.1-0.51.1
Context. condit. distance diff. score0.00.00.0-0.1-0.0
Locomotion velocity, session 10.20.20.3-0.60.3
Locomotion distance, session 11.11.41.6-1.3-1.1
Locomotion velocity, session 20.81.01.7-1.30.5
Locomotion distance, session 21.11.63.1-1.80.1
Locomotion velocity, session 31.01.22.1-1.4-0.6
Locomotion distance, session 32.02.23.8-2.00.8
Stereotopy head waving bouts, day 30.10.10.30.5-0.1
Stereotopy head waving duration, day 30.70.81.51.2-0.4
Locomotion velocity, session 70.20.20.30.2-0.5
Locomotion distance, session 70.40.50.6-0.70.8
Stereotopy head waving bouts, day 70.00.00.00.10.2
Stereotopy head waving duration, day 70.20.20.40.2-0.6
Locomotion velocity, session 81.31.62.8-1.7-0.6
Locomotion distance, session 81.32.03.6-1.9-0.7
Degree of sensitization distance1.61.72.41.6-0.9
Degree of sensitization stereotypy0.10.10.10.3-0.2
Condit. Reinf. active minus inactive responses0.60.71.31.1-0.2
Condit. Reinf. active-inactive response ratio0.91.01.71.3-0.4
Condit. Reinf. active responses0.10.20.40.60.1
Condit. Reinf. inactive responses0.40.50.5-0.70.7
Incentive salience index mean0.00.00.1-0.00.3
Condit. Reinf. lever presses1.41.92.1-1.31.5
Time in familiar zone, hab. session 11.41.31.80.91.3
Time in novel zone, hab. session 10.50.50.8-0.3-0.9
Total zone transitions, hab. session 11.11.62.0-1.4-1.1
Total locomotion distance, hab. session 10.40.60.6-0.8-0.7
Locomotion velocity, hab. session 10.40.60.6-0.8-0.8
Time in familiar zone, hab. session 20.30.40.7-0.00.8
Time in novel zone, hab. session 20.10.10.20.4-0.1
Total zone transitions, hab. session 21.51.93.7-1.9-0.4
Total locomotion distance, hab. session 20.60.71.0-1.0-0.7
Locomotion velocity, hab. session 20.60.81.2-1.1-0.6
Novel to familiar place preference ratio0.40.50.80.3-0.9
Novelty place preference0.50.50.80.4-0.9
Time in novel zone, NPP test0.70.71.10.6-1.0
Total zone transitions, NPP test3.04.44.6-2.1-2.0
Total locomotion distance, NPP test1.01.41.9-1.0-1.4
Locomotion velocity, NPP test1.11.62.1-1.1-1.5
Pavlov. Cond. lever latency4.65.96.32.3-2.5
Pavlov. Cond. magazine entry latency4.76.19.0-1.83.0
Pavlov. Cond. change in total contacts1.11.22.4-0.21.5
Pavlov. Cond. index score4.76.08.8-1.83.0
Pavlov. Cond. latency score4.96.28.4-2.02.9
Pavlov. Cond. lever contacts3.03.63.7-1.91.9
Pavlov. Cond. magazine entry number5.16.310.41.5-3.2
Pavlov. Cond. intertrial magazine entries0.40.40.50.6-0.7
Pavlov. Cond. lever-magazine prob. diff.4.25.37.8-1.72.8
Pavlov. Cond. response bias5.16.29.2-1.83.0
Bone: apparent density0.00.00.0-0.1-0.2
Bone surface0.30.50.9-0.90.2
Bone volume0.20.30.7-0.8-0.0
Bone: connectivity density0.10.20.30.30.6
Bone: cortical apparent density0.10.10.20.20.5
Bone: cortical area0.10.10.3-0.10.5
Bone: cortical porosity0.60.71.31.10.3
Bone: cortical porosity0.70.81.21.10.6
Bone: cortical thickness0.00.10.10.1-0.4
Bone: cortical thickness0.00.00.00.0-0.0
Bone: cortical tissue density0.10.10.20.20.5
Bone: elastic displacement0.10.10.10.3-0.2
Bone: elastic work0.50.60.8-0.6-0.9
Bone: endosteal estimation0.10.20.30.6-0.3
Bone: endosteal perimeter0.81.62.5-0.81.6
Bone: final force0.40.61.20.2-1.1
Bone: final moment0.50.81.60.1-1.3
Bone: marrow area0.10.20.30.5-0.4
Bone: maximum diameter0.30.60.9-0.51.0
Bone: maximum force0.40.71.00.5-1.0
Bone: maximum moment0.40.71.20.5-1.1
Bone: minimum diameter0.30.60.7-0.70.8
Bone: periosteal estimation0.00.00.00.0-0.1
Bone: periosteal perimeter0.81.32.2-0.61.5
Bone: post-yield work0.00.00.0-0.2-0.1
Bone: stiffness0.20.30.40.7-0.3
Bone: tissue strength1.91.83.00.8-1.7
Bone: trabecular number0.50.80.8-0.90.9
Bone: trabecular spacing1.11.41.90.9-1.4
Bone: trabecular thickness0.30.30.6-0.8-0.3
Bone: trabecular tissue density0.20.20.5-0.0-0.7
Breakpoint value in progressive ratio session0.10.10.10.3-0.4
Distance traveled before self-admin0.00.00.00.00.0
Distance traveled after self-admin0.20.20.3-0.40.6
Delta time in closed arm before/after self-admin0.20.20.3-0.20.5
Delta time in open arm before/after self-admin0.20.20.40.3-0.6
Diff in mean of infusions in LGA sessions0.00.00.00.10.1
Extinction: sum of active levers before priming0.00.00.10.2-0.0
Active lever presses in extinction session 60.30.30.40.4-0.6
Delta distance traveled before/after self-admin0.10.10.2-0.40.3
Delta ambulatory time before/after self-admin0.20.20.40.0-0.6
Time in closed arm before self-admin0.91.11.50.8-1.2
Time in closed arm after self-admin0.00.00.00.10.0
Time in open arm before self-admin0.70.71.1-0.61.0
Time in open arm after self-admin0.10.10.1-0.10.3
Sum of active levers in priming session hrs 5-60.50.50.60.5-0.8
Time to tail flick, vehicle, before self-admin1.31.31.80.9-1.4
Time to tail flick, vehicle, after self-admin0.40.40.80.1-0.9
Time to tail flick, test, before self-admin0.10.10.1-0.0-0.3
Time to tail flick, test, after self-admin0.10.10.2-0.20.4
Delta time to tail flick, vehicle, before/after SA0.40.40.5-0.70.6
Delta time to tail flick, test, before/after SA0.30.30.5-0.20.7
Ambulatory time before self-admin0.10.10.1-0.00.3
Ambulatory time after self-admin0.00.00.0-0.20.2
Total heroin consumption0.80.91.60.5-1.3
Area under the delay curve1.11.21.9-0.71.4
Delay disc. indifference point, 0s delay0.10.10.1-0.20.2
Delay disc. indifference point, 16s delay0.60.60.8-0.60.9
Delay disc. indifference point, 2s delay0.20.20.3-0.30.5
Delay disc. indifference point, 24s delay0.40.40.6-0.40.8
Delay disc. indifference point, 4s delay1.21.32.1-0.71.4
Delay disc. indifference point, 8s delay1.01.11.8-0.61.3
Delay discount exponential model param1.31.42.20.7-1.5
Delay discount hyperbolic model param1.31.42.20.7-1.5
Fecal boli incidents, locomotor time 10.20.20.30.2-0.6
Change in fecal boli incidents, locomotor task0.00.00.00.2-0.1
Time >=10cm from walls, locomotor time 10.00.00.10.10.3
Bouts of movement, locomotor time 10.00.00.10.3-0.1
Total resting periods, locomotor time 10.00.00.10.3-0.1
Rest time, locomotor task time 10.40.40.8-0.10.9
Distance moved, locomotor task time 11.01.02.00.3-1.4
Vertical activity count, locomotor time 10.50.50.80.3-0.9
Time >=10cm from walls, locomotor time 20.80.91.50.5-1.2
Bouts of movement, locomotor time 20.10.10.1-0.3-0.1
Total resting periods, locomotor time 20.10.10.2-0.50.2
Rest time, locomotor task time 20.00.00.00.10.2
Distance moved, locomotor task time 20.50.61.10.3-1.0
Vertical activity count, locomotor time 20.00.00.0-0.1-0.2
Weight adjusted by age0.20.20.30.3-0.6
Seeking ratio, delayed vs. immediate footshock2.12.54.5-0.72.1
Locomotion in novel chamber0.10.10.1-0.20.3
Locomotion in novel chamber post-restriction0.40.50.90.4-1.0
Progressive ratio1.82.13.50.8-1.9
Food seeking constrained by brief footshock0.50.70.7-0.80.9
Seeking ratio, punishment vs. effort3.23.95.8-1.42.4
Run reversals in cocaine runway, females0.60.61.0-0.51.0
Run reversals in cocaine runway, males0.40.30.60.2-0.8
Latency to leave start box in cocaine runway0.20.20.40.1-0.6
Latency to leave start box in cocaine runway, F0.60.71.20.3-1.1
Latency to leave start box in cocaine runway, M0.10.10.1-0.20.3
Cd content in liver3.43.75.72.4-1.3
Co content in liver0.00.00.10.3-0.0
Cu content in liver2.53.04.41.3-2.1
Fe content in liver3.94.68.12.9-1.0
K content in liver1.01.01.1-0.9-1.1
Mg content in liver1.61.63.2-1.8-0.2
Mn content in liver1.01.21.4-1.2-1.0
Na content in liver1.31.42.41.5-0.6
Rb content in liver5.26.512.53.5-0.7
Se content in liver0.20.20.3-0.6-0.4
Sr content in liver2.42.24.2-2.1-0.3
Zn content in liver2.22.44.80.3-2.2