Best TWAS P=4.35e-09 · Best GWAS P=2.56e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Orc3 | alternative polyA | NM_001025282.1 | 0.02 | 1 | 0.01 | 8.6e-03 | -5.32 | 1.02e-07 | 0.03 | FALSE |
| Adipose | RGD1359108 | alternative polyA | XM_039109830.1 | 0.09 | 1 | 0.04 | 2.1e-05 | 5.18 | 2.22e-07 | 0.07 | FALSE |
| Adipose | Cnr1 | gene expression | Cnr1 | 0.1 | 1348 | 0.03 | 1.9e-04 | 5.18 | 2.23e-07 | 0.43 | FALSE |
| Adipose | RGD1359108 | gene expression | RGD1359108 | 0.19 | 1 | 0.09 | 8.8e-10 | 5.48 | 4.23e-08 | 0.4 | FALSE |
| Adipose | Slc35a1 | gene expression | Slc35a1 | 0.1 | 1555 | 0.06 | 2.2e-07 | 5.3 | 1.17e-07 | 0.52 | FALSE |
| Adipose | RGD1359108 | isoform ratio | XM_039109830.1 | 0.09 | 1 | 0.04 | 2.8e-05 | 5.78 | 7.54e-09 | 0.52 | FALSE |
| Adipose | Rars2 | intron excision ratio | chr5_49210334_49211494 | 0.03 | 1 | 0.02 | 3.4e-03 | -5.34 | 9.42e-08 | 0.04 | FALSE |
| Adipose | Slc35a1 | mRNA stability | Slc35a1 | 0.05 | 13 | 0.03 | 1.3e-04 | 5.27 | 1.34e-07 | 0.5 | FALSE |
| BLA | Rars2 | alternative polyA | XM_006237986.4 | 0.08 | 212 | 0.04 | 2.0e-03 | 5.25 | 1.51e-07 | 0.49 | FALSE |
| BLA | Rars2 | alternative polyA | NM_001106643.2 | 0.08 | 24 | 0.07 | 1.4e-04 | 5.18 | 2.25e-07 | 0.48 | FALSE |
| BLA | Rars2 | alternative polyA | XM_006237986.4 | 0.08 | 22 | 0.07 | 1.0e-04 | -5.18 | 2.26e-07 | 0.48 | FALSE |
| BLA | Cfap206 | gene expression | Cfap206 | 0.74 | 93 | 0.67 | 3.5e-47 | 5.27 | 1.35e-07 | 0.46 | FALSE |
| BLA | LOC102557269 | gene expression | LOC102557269 | 0.26 | 1 | 0.13 | 1.6e-07 | 5.74 | 9.50e-09 | 0.71 | FALSE |
| BLA | Orc3 | gene expression | Orc3 | 0.06 | 1 | 0.04 | 5.6e-03 | 5.18 | 2.22e-07 | 0.04 | FALSE |
| BLA | Rars2 | gene expression | Rars2 | 0.09 | 59 | 0.07 | 1.0e-04 | -5.18 | 2.25e-07 | 0.5 | FALSE |
| BLA | Rars2 | isoform ratio | XM_006237986.4 | 0.22 | 11 | 0.17 | 2.2e-09 | -5.32 | 1.03e-07 | 0.52 | FALSE |
| BLA | LOC102557269 | mRNA stability | LOC102557269 | 0.43 | 1 | 0.27 | 7.1e-15 | 5.77 | 7.75e-09 | 0.77 | FALSE |
| BLA | RGD1359108 | mRNA stability | RGD1359108 | 0.08 | 1022 | 0.04 | 4.8e-03 | 5.5 | 3.79e-08 | 0.61 | FALSE |
| Brain | RGD1359108 | alternative polyA | XM_039109830.1 | 0.14 | 1 | 0.09 | 8.9e-09 | 5.37 | 8.06e-08 | 0.26 | FALSE |
| Brain | LOC102557269 | gene expression | LOC102557269 | 0.49 | 1 | 0.15 | 2.1e-13 | 5.67 | 1.46e-08 | 0.65 | FALSE |
| Brain | Orc3 | gene expression | Orc3 | 0.1 | 1 | 0.06 | 2.9e-06 | 5.23 | 1.70e-07 | 0.44 | FALSE |
| Brain | Orc3 | isoform ratio | NM_001025282.1 | 0.04 | 26 | 0.03 | 6.6e-04 | 5.17 | 2.28e-07 | 0.47 | FALSE |
| Brain | Rars2 | isoform ratio | XM_006237986.4 | 0.13 | 1566 | 0.12 | 1.8e-11 | -5.29 | 1.22e-07 | 0.52 | FALSE |
| Brain | RGD1359108 | isoform ratio | XM_039109830.1 | 0.07 | 1 | 0.05 | 1.8e-05 | 5.67 | 1.46e-08 | 0.29 | FALSE |
| Brain | Slc35a1 | intron excision ratio | chr5_49226632_49230692 | 0.04 | 1556 | 0.02 | 4.5e-03 | -5.29 | 1.20e-07 | 0.48 | FALSE |
| Brain | LOC102557269 | mRNA stability | LOC102557269 | 0.33 | 1 | 0.22 | 4.0e-20 | 5.55 | 2.78e-08 | 0.5 | FALSE |
| Brain | RGD1359108 | mRNA stability | RGD1359108 | 0.1 | 1 | 0.08 | 1.3e-07 | -5.18 | 2.23e-07 | 0.11 | FALSE |
| Brain | Slc35a1 | mRNA stability | Slc35a1 | 0.1 | 96 | 0.06 | 1.9e-06 | -5.23 | 1.66e-07 | 0.53 | FALSE |
| IL | LOC102557269 | gene expression | LOC102557269 | 0.24 | 1 | 0.05 | 2.3e-02 | 5.36 | 8.34e-08 | 0.05 | FALSE |
| IL | Slc35a1 | gene expression | Slc35a1 | 0.2 | 1 | 0.09 | 3.5e-03 | 5.36 | 8.34e-08 | 0.05 | FALSE |
| IL | Cnr1 | mRNA stability | Cnr1 | 0.24 | 1 | 0.05 | 2.3e-02 | 5.43 | 5.50e-08 | 0.06 | FALSE |
| LHb | Cfap206 | gene expression | Cfap206 | 0.71 | 13 | 0.4 | 1.2e-10 | -5.4 | 6.71e-08 | 0.46 | FALSE |
| Liver | RGD1359108 | alternative polyA | NM_001007702.2 | 0.03 | 1 | 0.01 | 1.2e-02 | -5.33 | 9.61e-08 | 0.03 | FALSE |
| Liver | RGD1359108 | alternative polyA | XM_039109830.1 | 0.03 | 1 | 0.02 | 3.4e-03 | 5.33 | 9.61e-08 | 0.03 | FALSE |
| Liver | Slc35a1 | gene expression | Slc35a1 | 0.12 | 1 | 0.09 | 7.5e-10 | -5.35 | 9.03e-08 | 0.64 | FALSE |
| Liver | RGD1359108 | isoform ratio | NM_001007702.2 | 0.03 | 1 | 0.02 | 3.8e-03 | -5.33 | 9.61e-08 | 0.03 | FALSE |
| Liver | Rars2 | intron excision ratio | chr5_49222641_49232932 | 0.03 | 1 | 0.01 | 7.5e-02 | -5.36 | 8.34e-08 | 0.03 | FALSE |
| NAcc | Orc3 | alternative polyA | NM_001025282.1 | 0.04 | 1566 | 0.05 | 3.4e-06 | 5.29 | 1.23e-07 | 0.48 | FALSE |
| NAcc | Orc3 | alternative polyA | XM_006237995.4 | 0.03 | 1566 | 0.04 | 3.2e-05 | -5.28 | 1.26e-07 | 0.48 | FALSE |
| NAcc | RGD1359108 | alternative polyA | NM_001007702.2 | 0.03 | 1 | 0.01 | 1.8e-02 | -5.77 | 7.77e-09 | 0.07 | FALSE |
| NAcc | Cfap206 | alternative TSS | NM_001079701.1 | 0.06 | 5 | 0.05 | 6.7e-07 | -5.44 | 5.39e-08 | 0.44 | FALSE |
| NAcc | RGD1359108 | alternative TSS | XM_039109829.1 | 0.05 | 1 | 0.04 | 1.9e-05 | 5.6 | 2.12e-08 | 0.18 | FALSE |
| NAcc | RGD1359108 | alternative TSS | NM_001007702.2 | 0.05 | 1 | 0.04 | 5.1e-05 | -5.6 | 2.12e-08 | 0.16 | FALSE |
| NAcc | RGD1359108 | alternative TSS | XM_039109829.1 | 0.05 | 1 | 0.04 | 3.3e-05 | 5.74 | 9.50e-09 | 0.33 | FALSE |
| NAcc | Cfap206 | gene expression | Cfap206 | 0.87 | 1518 | 0.58 | 5.2e-83 | -5.31 | 1.12e-07 | 0.46 | FALSE |
| NAcc | LOC102557269 | gene expression | LOC102557269 | 0.21 | 1 | 0.25 | 9.4e-29 | 5.74 | 9.50e-09 | 0.74 | FALSE |
| NAcc | Orc3 | isoform ratio | NM_001025282.1 | 0.02 | 3 | 0.02 | 1.2e-03 | 5.31 | 1.07e-07 | 0.41 | FALSE |
| NAcc | Slc35a1 | intron excision ratio | chr5_49226632_49230692 | 0.04 | 1556 | 0.03 | 1.9e-04 | -5.21 | 1.88e-07 | 0.52 | FALSE |
| NAcc | Slc35a1 | intron excision ratio | chr5_49231423_49233546 | 0.03 | 1556 | 0.02 | 9.0e-04 | 5.24 | 1.58e-07 | 0.53 | FALSE |
| NAcc | LOC102557269 | mRNA stability | LOC102557269 | 0.25 | 12 | 0.11 | 1.9e-12 | -5.79 | 7.02e-09 | 0.72 | FALSE |
| NAcc | Slc35a1 | mRNA stability | Slc35a1 | 0.03 | 1556 | 0.02 | 5.2e-03 | 5.24 | 1.57e-07 | 0.51 | FALSE |
| OFC | Cnr1 | alternative polyA | XM_017593151.2 | 0.38 | 1 | 0.26 | 7.2e-07 | -5.26 | 1.46e-07 | 0.17 | FALSE |
| PL | RGD1359108 | alternative TSS | XM_039109829.1 | 0.03 | 1 | 0.01 | 2.8e-02 | 5.76 | 8.56e-09 | 0.05 | FALSE |
| PL | Cfap206 | gene expression | Cfap206 | 0.29 | 1518 | 0.34 | 7.6e-39 | -5.22 | 1.82e-07 | 0.46 | FALSE |
| PL | LOC102557269 | gene expression | LOC102557269 | 0.19 | 1023 | 0.18 | 6.6e-19 | -5.63 | 1.85e-08 | 0.8 | FALSE |
| PL | LOC120102853 | gene expression | LOC120102853 | 0.15 | 26 | 0.18 | 1.7e-19 | -5.19 | 2.11e-07 | 0.3 | FALSE |
| PL | Rars2 | isoform ratio | XM_006237986.4 | 0.09 | 3 | 0.11 | 3.0e-12 | -5.47 | 4.41e-08 | 0.52 | FALSE |
| PL | RGD1359108 | isoform ratio | XM_039109830.1 | 0.08 | 26 | 0.06 | 7.5e-07 | 5.32 | 1.05e-07 | 0.76 | FALSE |
| PL | LOC102557269 | mRNA stability | LOC102557269 | 0.14 | 1023 | 0.11 | 1.0e-11 | -5.71 | 1.10e-08 | 0.75 | FALSE |
| PL | RGD1359108 | mRNA stability | RGD1359108 | 0.09 | 1 | 0.04 | 3.3e-05 | -5.87 | 4.35e-09 | 0.75 | TRUE |
| pVTA | Orc3 | alternative polyA | NM_001025282.1 | 0.12 | 1566 | 0.08 | 2.2e-04 | 5.25 | 1.53e-07 | 0.5 | FALSE |
| pVTA | Orc3 | alternative polyA | XM_006237995.4 | 0.13 | 1566 | 0.09 | 1.0e-04 | -5.22 | 1.82e-07 | 0.5 | FALSE |
| pVTA | Cfap206 | gene expression | Cfap206 | 0.6 | 496 | 0.62 | 2.5e-33 | 5.26 | 1.41e-07 | 0.44 | FALSE |
| pVTA | Cnr1 | gene expression | Cnr1 | 0.33 | 1350 | 0.18 | 2.0e-08 | 5.28 | 1.31e-07 | 0.48 | FALSE |
| pVTA | LOC102557269 | gene expression | LOC102557269 | 0.23 | 1 | 0.12 | 5.7e-06 | 5.78 | 7.66e-09 | 0.66 | FALSE |
| RMTg | RGD1359108 | gene expression | RGD1359108 | 0.31 | 277 | 0.12 | 3.9e-04 | 5.82 | 5.97e-09 | 0.72 | FALSE |
| RMTg | Rars2 | intron excision ratio | chr5_49193093_49195837 | 0.35 | 19 | 0.41 | 5.1e-12 | -5.18 | 2.25e-07 | 0.47 | FALSE |
| RMTg | Rars2 | intron excision ratio | chr5_49211589_49213311 | 0.11 | 1566 | 0.09 | 1.7e-03 | -5.24 | 1.65e-07 | 0.45 | FALSE |
| RMTg | Rars2 | mRNA stability | Rars2 | 0.11 | 25 | 0.13 | 2.5e-04 | 5.22 | 1.76e-07 | 0.46 | FALSE |