Hub : Traits : body_g : ← →

chr5:47,710,012-49,968,409

Best TWAS P=6.72386e-09 · Best GWAS P=2.564392e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Slc35a1	alternative TSS	ENSRNOT00000011969	0.02	0.02	top1	1	0.02	3.7e-03	5.4	5.4	5.3e-08	0.71	0.05	0.04	FALSE
2	Adipose	Slc35a1	alternative TSS	ENSRNOT00000081150	0.02	0.02	top1	1	0.02	4.4e-03	5.4	-5.4	5.3e-08	-0.71	0.05	0.04	FALSE
3	Adipose	Cnr1	gene expression	ENSRNOG00000008223	0.06	0.03	blup	1345	0.03	3.1e-04	5.0	5.2	2.5e-07	0.81	0.56	0.42	FALSE
4	Adipose	Orc3	gene expression	ENSRNOG00000008314	0.03	0.02	top1	1	0.02	5.9e-03	5.3	-5.3	1.3e-07	-0.79	0.05	0.03	FALSE
5	Adipose	RGD1359108	gene expression	ENSRNOG00000009478	0.13	0.06	top1	1	0.06	1.9e-07	5.8	-5.8	6.7e-09	-0.86	0.20	0.78	TRUE
6	Adipose	Slc35a1	isoform ratio	ENSRNOT00000011969	0.02	0.01	top1	1	0.01	8.6e-03	5.3	5.3	1.3e-07	0.71	0.05	0.03	FALSE
7	Adipose	Rars2	intron excision ratio	chr5:49210334:49211494	0.03	0.02	top1	1	0.02	1.2e-03	5.4	5.4	8.3e-08	0.80	0.05	0.04	FALSE
8	Adipose	Slc35a1	mRNA stability	ENSRNOG00000008908	0.06	0.03	top1	1	0.03	3.0e-04	5.2	5.2	1.9e-07	0.80	0.14	0.11	FALSE
9	BLA	Rars2	gene expression	ENSRNOG00000008643	0.08	0.07	blup	1563	0.08	7.2e-05	5.4	5.2	2.0e-07	0.84	0.48	0.51	FALSE
10	BLA	Cfap206	gene expression	ENSRNOG00000009061	0.85	0.60	lasso	53	0.65	2.7e-45	5.2	-5.2	1.5e-07	-0.86	0.56	0.44	FALSE
11	BLA	Rars2	mRNA stability	ENSRNOG00000008643	0.15	0.12	lasso	12	0.12	5.2e-07	5.4	5.4	7.0e-08	0.87	0.47	0.53	FALSE
12	BLA	Slc35a1	mRNA stability	ENSRNOG00000008908	0.07	0.04	top1	1	0.04	2.9e-03	5.3	5.3	9.3e-08	0.77	0.07	0.05	FALSE
13	BLA	RGD1359108	mRNA stability	ENSRNOG00000009478	0.11	0.06	lasso	22	0.07	1.8e-04	5.8	5.7	1.2e-08	-0.90	0.25	0.73	TRUE
14	Brain	Rars2	alternative polyA	ENSRNOT00000011688	0.26	0.18	top1	1	0.18	4.4e-16	5.3	-5.3	1.1e-07	-0.85	0.42	0.58	FALSE
15	Brain	Rars2	alternative polyA	ENSRNOT00000115962	0.26	0.18	top1	1	0.18	3.9e-16	5.3	5.3	1.1e-07	0.85	0.42	0.58	FALSE
16	Brain	Orc3	gene expression	ENSRNOG00000008314	0.03	0.02	blup	1563	0.02	2.7e-03	5.2	-5.3	1.2e-07	-0.87	0.47	0.49	FALSE
17	Brain	Cfap206	gene expression	ENSRNOG00000009061	0.51	0.63	lasso	26	0.63	9.3e-76	5.2	-5.4	7.4e-08	-0.70	0.56	0.44	TRUE
18	Brain	Rars2	isoform ratio	ENSRNOT00000011688	0.05	0.07	top1	1	0.07	9.5e-07	5.3	-5.3	9.3e-08	-0.84	0.34	0.53	FALSE
19	Brain	Rars2	isoform ratio	ENSRNOT00000115962	0.05	0.07	top1	1	0.07	5.9e-07	5.3	5.3	9.3e-08	0.84	0.33	0.52	FALSE
20	Brain	Slc35a1	intron excision ratio	chr5:49226632:49230692	0.05	0.02	blup	1548	0.03	8.2e-04	5.1	-5.3	1.2e-07	-0.87	0.50	0.49	FALSE
21	Brain	Slc35a1	mRNA stability	ENSRNOG00000008908	0.08	0.05	blup	1548	0.06	2.5e-06	5.2	5.3	1.5e-07	0.87	0.47	0.53	FALSE
22	Brain	RGD1359108	mRNA stability	ENSRNOG00000009478	0.16	0.11	blup	1015	0.12	3.0e-11	5.8	5.7	9.4e-09	0.99	0.24	0.76	TRUE
23	IL	Rars2	alternative polyA	ENSRNOT00000011688	0.22	0.12	top1	1	0.12	8.3e-04	5.3	-5.3	1.5e-07	-0.86	0.09	0.06	FALSE
24	IL	Rars2	alternative polyA	ENSRNOT00000115962	0.22	0.12	top1	1	0.12	9.2e-04	5.3	5.3	1.5e-07	0.86	0.09	0.06	FALSE
25	IL	Cfap206	gene expression	ENSRNOG00000009061	0.42	0.21	blup	1500	0.23	3.9e-06	5.3	-5.2	2.5e-07	-0.84	0.56	0.44	FALSE
26	IL	Rars2	isoform ratio	ENSRNOT00000011688	0.16	0.07	enet	3	0.15	1.7e-04	5.3	-5.3	1.4e-07	-0.87	0.40	0.38	FALSE
27	IL	Rars2	isoform ratio	ENSRNOT00000115962	0.15	0.07	enet	4	0.13	4.5e-04	5.3	5.3	1.5e-07	0.87	0.39	0.36	FALSE
28	IL	Slc35a1	intron excision ratio	chr5:49230826:49231247	0.14	0.04	top1	1	0.04	4.6e-02	5.2	5.2	2.0e-07	0.80	0.08	0.05	FALSE
29	IL	Cnr1	mRNA stability	ENSRNOG00000008223	0.23	0.07	lasso	2	0.08	5.6e-03	5.1	-5.1	3.0e-07	-0.66	0.44	0.35	FALSE
30	LHb	Cfap206	gene expression	ENSRNOG00000009061	0.70	0.39	lasso	5	0.41	7.2e-11	5.3	-5.3	1.2e-07	-0.88	0.54	0.46	FALSE
31	LHb	Rars2	mRNA stability	ENSRNOG00000008643	0.17	0.09	lasso	3	0.10	2.8e-03	5.2	5.2	2.5e-07	0.86	0.41	0.38	FALSE
32	Liver	Rars2	alternative TSS	ENSRNOT00000011688	0.12	0.10	blup	1562	0.10	4.8e-11	5.3	-5.1	2.7e-07	-0.83	0.52	0.48	FALSE
33	Liver	Orc3	gene expression	ENSRNOG00000008314	0.02	0.01	top1	1	0.01	2.1e-02	5.2	-5.2	2.1e-07	-0.83	0.05	0.03	FALSE
34	Liver	Slc35a1	gene expression	ENSRNOG00000008908	0.14	0.09	top1	1	0.09	1.9e-10	5.1	5.1	3.1e-07	0.81	0.65	0.35	FALSE
35	Liver	Slc35a1	isoform ratio	ENSRNOT00000011969	0.03	0.02	top1	1	0.02	2.6e-03	5.4	5.4	5.3e-08	0.83	0.05	0.04	FALSE
36	Liver	Slc35a1	isoform ratio	ENSRNOT00000081150	0.04	0.00	blup	1548	0.01	1.8e-02	5.4	-5.2	1.8e-07	-0.87	0.34	0.39	FALSE
37	Liver	Rars2	intron excision ratio	chr5:49184400:49186141	0.21	0.12	lasso	6	0.12	1.8e-13	5.2	-5.2	2.5e-07	-0.82	0.57	0.43	FALSE
38	Liver	Rars2	intron excision ratio	chr5:49184400:49187818	0.15	0.11	top1	1	0.11	3.0e-12	5.2	5.2	2.5e-07	0.81	0.62	0.38	FALSE
39	Liver	Rars2	intron excision ratio	chr5:49222641:49232932	0.03	0.01	enet	18	0.01	4.3e-02	5.3	5.3	1.0e-07	0.89	0.40	0.39	FALSE
40	NAcc	Cfap206	gene expression	ENSRNOG00000009061	0.53	0.29	top1	1	0.29	3.3e-07	5.3	-5.3	1.0e-07	-0.86	0.25	0.25	FALSE
41	NAcc	Rars2	intron excision ratio	chr5:49196931:49198935	0.16	0.08	top1	1	0.08	9.1e-03	5.2	-5.2	2.4e-07	-0.86	0.08	0.05	FALSE
42	NAcc2	Rars2	alternative polyA	ENSRNOT00000011688	0.08	0.04	top1	1	0.04	2.0e-03	5.4	-5.4	8.0e-08	-0.83	0.06	0.05	FALSE
43	NAcc2	Rars2	alternative polyA	ENSRNOT00000115962	0.07	0.04	top1	1	0.04	2.2e-03	5.4	5.4	8.0e-08	0.82	0.06	0.05	FALSE
44	NAcc2	Cfap206	gene expression	ENSRNOG00000009061	0.56	0.40	lasso	32	0.50	1.1e-30	5.3	-5.2	2.0e-07	-0.86	0.54	0.46	TRUE
45	NAcc2	Rars2	intron excision ratio	chr5:49210334:49211494	0.06	0.03	blup	1563	0.03	9.4e-03	4.3	5.2	2.1e-07	0.87	0.40	0.40	FALSE
46	NAcc2	RGD1359108	mRNA stability	ENSRNOG00000009478	0.13	0.05	top1	1	0.05	8.9e-04	5.8	5.8	7.2e-09	0.98	0.05	0.08	FALSE
47	OFC	RGD1359108	gene expression	ENSRNOG00000009478	0.29	0.08	top1	1	0.08	5.7e-03	5.3	5.3	1.2e-07	0.61	0.06	0.05	FALSE
48	PL2	Rars2	alternative polyA	ENSRNOT00000011688	0.08	0.06	top1	1	0.06	3.9e-04	5.4	-5.4	8.3e-08	-0.87	0.07	0.06	FALSE
49	PL2	Rars2	alternative polyA	ENSRNOT00000115962	0.08	0.06	top1	1	0.06	2.8e-04	5.4	5.4	8.3e-08	0.87	0.07	0.07	FALSE
50	PL2	Slc35a1	mRNA stability	ENSRNOG00000008908	0.06	0.03	top1	1	0.03	1.4e-02	5.1	5.1	3.1e-07	0.87	0.07	0.04	FALSE
51	PL2	RGD1359108	mRNA stability	ENSRNOG00000009478	0.11	0.07	top1	1	0.07	9.4e-05	5.4	5.4	8.1e-08	0.95	0.08	0.05	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.