Hub : Genes

Impdh2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000031965 0.08 0.06 9.3e-04 0.02 0.02 0.02 0.02 1.5e-03 3.5e-03 3.4e-03 3.3e-03
2 Brain gene expression ENSRNOG00000031965 0.06 0.04 9.1e-03 0.03 0.02 0.03 0.03 5.8e-04 7.2e-03 5.4e-04 7.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail1.03.24.2-1.52.1
BMI without tail2.75.66.4-2.22.5
Body weight6.025.526.0-5.05.1
Epididymis fat weight0.10.20.3-0.50.2
Glucose0.20.30.5-0.7-0.3
Heart weight2.94.24.6-1.92.1
Left kidney weight0.72.13.0-1.71.1
Right kidney weight0.10.40.7-0.8-0.1
Tail length5.717.219.9-4.53.8
Length with tail7.126.030.1-5.54.7
Length without tail4.39.410.8-3.32.8
Liver weight, left0.10.10.2-0.40.1
Liver weight, right1.01.72.9-1.70.7
Parametrial fat weight0.81.61.8-1.41.2
Retroperitoneal fat weight0.31.01.3-1.10.8
Intraocular pressure0.50.81.3-1.10.5
Extensor digitorum longus weight0.10.40.60.8-0.3
Soleus weight3.811.111.9-3.53.2
Tibialis anterior weight0.00.00.1-0.10.2
Tibia length6.217.421.2-4.63.7
Number of licking bursts0.10.20.30.50.2
Food consumed during 24 hour testing period1.41.61.7-1.21.3
Times rat made contact with spout0.70.80.8-0.80.9
Mean time between licks in bursts1.52.02.11.5-1.4
Mean num. licks in bursts0.50.51.0-1.00.2
Std. dev. time between licks in bursts3.84.66.12.5-1.8
Water consumed over 24 hours0.00.10.1-0.10.3
Indifference point 0 sec1.11.82.1-1.21.4
Indifference point AUC0.10.20.2-0.4-0.4
Indifference point function ln k0.20.20.50.7-0.1
Indifference point function log k0.20.20.50.7-0.1
Delay discounting total patch changes 0 sec1.42.22.7-1.31.6
Delay discounting total patch changes 12 sec0.71.01.0-1.01.0
Delay discounting total patch changes 18 sec1.62.12.2-1.51.4
Delay discounting total patch changes 24 sec2.22.82.9-1.71.6
Delay discounting total patch changes 6 sec0.10.10.2-0.40.2
Delay discounting time to switch 0 sec0.10.10.20.5-0.0
Delay discounting water rate 0 sec0.20.40.5-0.50.7
Delay discounting water rate 12 sec0.40.71.0-0.51.0
Delay discounting water rate 18 sec0.00.10.1-0.3-0.1
Delay discounting water rate 24 sec0.71.01.3-1.10.8
Delay discounting water rate 6 sec0.20.30.5-0.70.3
Locomotor activity5.08.09.1-3.02.6
Locomotor testing distance4.16.88.3-2.92.3
Locomotor testing rearing0.00.00.1-0.30.2
Light reinforcement 10.51.01.2-1.10.9
Light reinforcement 20.20.20.40.1-0.6
Reaction time number correct1.62.33.51.1-1.9
Reaction time mean minus median0.20.20.5-0.7-0.0
Reaction time mean minus median AUC0.30.40.8-0.90.1
Reaction time num false alarms0.50.60.70.8-0.8
Reaction time num false alarms AUC0.20.30.30.5-0.5
Reaction time trials correct on left1.62.33.51.1-1.9
Reaction time trials on left1.62.33.51.1-1.9
Reaction time mean0.00.00.00.1-0.0
Reaction time mean AUC0.00.00.00.2-0.2
Median of all reaction times0.10.10.20.4-0.2
Reaction time omissions0.30.40.60.8-0.4
Reaction time false alarm rate0.00.00.10.10.3
Reaction time premature initiation rate1.62.12.5-1.31.6
Reaction time premature initiations0.30.40.4-0.60.6
Std. dev. reaction times0.10.10.2-0.4-0.0
Reaction time trials completed1.62.33.51.1-1.9
Reaction time trials AUC2.02.94.21.2-2.0
Social response proportion0.20.20.4-0.30.6
Social responses0.20.30.6-0.80.1
Social time0.40.50.50.7-0.6
Conditioned locomotion2.93.53.71.8-1.9
Cocaine response after cond. corrected0.30.30.4-0.60.5
Cocaine response after cond. not corrected1.51.62.2-1.51.0
Cocaine response before conditioning0.70.81.3-1.20.6
Saline control response0.81.11.5-1.20.8
Condit. Reinf. active minus inactive responses1.51.81.8-1.31.4
Condit. Reinf. active-inactive response ratio1.11.11.4-1.20.9
Condit. Reinf. active responses1.52.02.3-1.31.5
Condit. Reinf. inactive responses0.00.00.10.20.2
Condit. Reinf. lever presses1.82.42.5-1.51.6
Condit. Reinf. lever reinforcers received1.72.42.9-1.41.7
Pavlov. Cond. lever latency0.20.20.20.5-0.5
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.2
Pavlov. Cond. change in total contacts1.92.72.8-1.61.7
Pavlov. Cond. index score0.10.10.1-0.20.3
Pavlov. Cond. latency score0.00.10.1-0.20.3
Pavlov. Cond. lever contacts0.50.81.0-1.00.7
Pavlov. Cond. magazine entry number0.20.30.4-0.60.4
Pavlov. Cond. intertrial magazine entries0.40.50.90.9-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.20.2
Pavlov. Cond. response bias0.00.00.0-0.1-0.0
Conditioned reinforcement - actives0.30.30.40.4-0.6
Conditioned reinforcement - inactives0.80.91.41.2-0.6
Conditioned locomotion0.40.50.70.6-0.8
Intermittent access intake day 1-15 change0.90.91.61.3-0.4
Intermittent access intake escalation0.90.91.61.3-0.4
Intermittent access intake escalation 20.50.50.91.00.3
Intermitt. access day 1 inactive lever presses0.00.00.1-0.20.1
Intermitt. access day 15 inactive lever presses0.50.51.01.0-0.2
Intermitt. access escalation Index0.00.00.00.0-0.1
Intermittent access day 1 total infusions0.00.00.0-0.00.0
Intermittent access day 15 total infusions0.50.61.11.0-0.4
Intermittent access terminal intake (last 3 days)0.30.30.60.8-0.2
Intermittent access total infusions0.50.50.80.9-0.5
Intermittent access day 1 locomotion0.10.10.10.3-0.3
Intermittent access day 15 total locomotion1.51.61.71.2-1.3
Intermittent access total locomotion1.82.02.11.4-1.4
Intermittent access standard deviation0.40.50.80.40.9
Cocaine induced anxiety0.00.00.10.20.2
Post-drug Anxiety0.00.00.0-0.20.1
Baseline Anxiety0.80.91.30.7-1.1
Lifetime Intake0.50.60.80.9-0.7
Incentive Sensitization - Responses1.01.01.31.1-0.9
Incentive Sensitization - Breakpoint1.01.01.31.1-0.8
Progressive ratio test 1 active lever presses0.10.10.20.2-0.4
Progressive ratio test 1 breakpoint0.20.20.30.2-0.5
Progressive ratio test 1 inactive lever presses0.30.30.40.7-0.3
Progressive ratio test 2 active lever presses0.80.91.01.0-0.8
Progressive ratio test 2 breakpoint0.50.50.70.8-0.6
Progressive ratio test 2 inactive lever presses1.21.42.41.5-0.6
Total sessions with >9 infusions0.00.00.10.3-0.0
Short access day 1 total inactive lever presses5.05.66.02.3-2.5
Short access day 10 total inactive lever presses0.40.50.8-0.40.9
Short access day 1 total infusions0.80.81.00.8-1.0
Short access day 10 total infusions0.20.20.20.5-0.5
Short access total infusions1.21.31.41.1-1.2
Short access day 1 locomotion0.00.00.00.0-0.1
Short access day 10 total locomotion0.10.10.10.2-0.3
Short access total locomotion0.10.10.10.1-0.3
Compulsive drug intake0.30.30.60.2-0.8
One hour access (0.3 mA shock)0.60.70.80.9-0.8
One hour access (shock baseline)0.10.10.20.40.1
Number of responses in last shaping day0.20.20.40.6-0.4
Context. condit. distance diff. score0.00.00.0-0.1-0.0
Locomotion velocity, session 10.70.71.40.2-1.2
Locomotion distance, session 10.50.61.3-1.10.1
Locomotion velocity, session 20.30.40.50.5-0.7
Locomotion distance, session 20.10.20.40.1-0.6
Locomotion velocity, session 30.10.10.1-0.3-0.3
Locomotion distance, session 31.11.21.21.0-1.1
Stereotopy head waving bouts, day 30.30.40.7-0.20.8
Stereotopy head waving duration, day 30.30.40.6-0.40.8
Locomotion velocity, session 70.00.00.0-0.10.0
Locomotion distance, session 71.11.41.41.2-1.1
Stereotopy head waving bouts, day 70.00.00.0-0.0-0.2
Stereotopy head waving duration, day 70.30.40.6-0.80.4
Locomotion velocity, session 80.20.20.4-0.6-0.1
Locomotion distance, session 80.20.30.6-0.7-0.4
Degree of sensitization distance1.01.01.0-1.01.0
Degree of sensitization stereotypy0.10.10.1-0.3-0.3
Condit. Reinf. active minus inactive responses0.00.00.00.2-0.0
Condit. Reinf. active-inactive response ratio0.00.00.0-0.00.1
Condit. Reinf. active responses0.00.00.00.10.2
Condit. Reinf. inactive responses0.10.10.10.4-0.1
Incentive salience index mean0.10.10.10.4-0.2
Condit. Reinf. lever presses0.81.11.31.1-1.0
Time in familiar zone, hab. session 10.90.91.41.2-0.6
Time in novel zone, hab. session 10.40.40.6-0.70.5
Total zone transitions, hab. session 10.30.40.7-0.80.2
Total locomotion distance, hab. session 10.30.40.6-0.80.4
Locomotion velocity, hab. session 10.30.40.7-0.80.3
Time in familiar zone, hab. session 20.50.50.60.8-0.6
Time in novel zone, hab. session 20.00.00.00.0-0.2
Total zone transitions, hab. session 20.00.10.1-0.3-0.2
Total locomotion distance, hab. session 20.50.61.0-1.00.6
Locomotion velocity, hab. session 20.40.50.8-0.90.4
Novel to familiar place preference ratio0.30.30.6-0.80.1
Novelty place preference0.30.30.6-0.8-0.0
Time in novel zone, NPP test0.40.40.8-0.90.2
Total zone transitions, NPP test1.82.54.1-2.01.0
Total locomotion distance, NPP test1.31.82.3-1.51.1
Locomotion velocity, NPP test1.21.82.5-1.61.0
Pavlov. Cond. lever latency3.64.65.2-2.32.0
Pavlov. Cond. magazine entry latency4.86.27.82.8-2.1
Pavlov. Cond. change in total contacts1.21.31.91.4-0.8
Pavlov. Cond. index score4.25.47.32.7-1.9
Pavlov. Cond. latency score4.55.87.32.7-2.1
Pavlov. Cond. lever contacts1.61.92.51.6-1.2
Pavlov. Cond. magazine entry number5.26.48.5-2.92.1
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.50.4
Pavlov. Cond. lever-magazine prob. diff.3.54.46.32.5-1.6
Pavlov. Cond. response bias4.55.57.52.7-1.9
Bone: apparent density0.10.10.3-0.1-0.5
Bone surface0.10.10.20.3-0.5
Bone volume0.20.30.50.1-0.7
Bone: connectivity density0.40.60.90.6-0.9
Bone: cortical apparent density0.30.40.60.5-0.8
Bone: cortical area0.10.20.40.6-0.2
Bone: cortical porosity0.30.30.60.2-0.8
Bone: cortical porosity0.60.61.10.5-1.0
Bone: cortical thickness0.20.40.8-0.20.9
Bone: cortical thickness0.00.00.0-0.00.0
Bone: cortical tissue density0.40.50.70.5-0.8
Bone: elastic displacement0.10.10.3-0.00.5
Bone: elastic work0.40.50.6-0.70.7
Bone: endosteal estimation0.00.00.0-0.2-0.2
Bone: endosteal perimeter1.53.03.61.6-1.9
Bone: final force0.91.41.7-1.11.3
Bone: final moment1.21.92.3-1.21.5
Bone: marrow area0.00.00.1-0.2-0.1
Bone: maximum diameter0.30.50.70.8-0.6
Bone: maximum force0.61.01.2-0.91.1
Bone: maximum moment0.71.31.5-1.01.2
Bone: minimum diameter0.61.11.21.0-1.1
Bone: periosteal estimation0.00.00.00.1-0.1
Bone: periosteal perimeter1.42.42.51.5-1.6
Bone: post-yield work0.10.20.3-0.30.5
Bone: stiffness0.10.10.2-0.30.4
Bone: tissue strength3.33.14.1-1.52.0
Bone: trabecular number1.32.02.91.0-1.7
Bone: trabecular spacing2.43.14.4-1.32.1
Bone: trabecular thickness0.20.30.4-0.3-0.7
Bone: trabecular tissue density0.40.50.5-0.70.7
Breakpoint value in progressive ratio session0.40.40.5-0.70.6
Distance traveled before self-admin0.70.80.80.9-0.9
Distance traveled after self-admin1.61.81.81.3-1.3
Delta time in closed arm before/after self-admin0.10.10.20.2-0.4
Delta time in open arm before/after self-admin0.10.10.1-0.30.2
Diff in mean of infusions in LGA sessions1.51.62.8-0.71.7
Extinction: sum of active levers before priming0.00.00.0-0.20.2
Active lever presses in extinction session 60.10.10.1-0.3-0.3
Delta distance traveled before/after self-admin0.00.00.10.3-0.1
Delta ambulatory time before/after self-admin0.30.30.4-0.60.4
Time in closed arm before self-admin1.21.42.6-0.51.6
Time in closed arm after self-admin0.00.00.00.1-0.0
Time in open arm before self-admin0.60.70.90.6-1.0
Time in open arm after self-admin0.60.61.00.5-1.0
Sum of active levers in priming session hrs 5-60.70.60.7-0.80.8
Time to tail flick, vehicle, before self-admin2.72.72.9-1.61.7
Time to tail flick, vehicle, after self-admin0.70.81.1-0.61.0
Time to tail flick, test, before self-admin0.20.20.2-0.40.4
Time to tail flick, test, after self-admin0.20.20.40.00.6
Delta time to tail flick, vehicle, before/after SA0.50.50.80.9-0.5
Delta time to tail flick, test, before/after SA0.10.10.20.50.0
Ambulatory time before self-admin0.30.40.70.8-0.2
Ambulatory time after self-admin1.31.51.81.1-1.3
Total heroin consumption1.01.21.7-0.91.3
Area under the delay curve2.22.32.51.5-1.6
Delay disc. indifference point, 0s delay0.00.00.00.0-0.1
Delay disc. indifference point, 16s delay1.11.11.41.2-1.0
Delay disc. indifference point, 2s delay0.40.50.70.5-0.8
Delay disc. indifference point, 24s delay1.41.31.41.2-1.1
Delay disc. indifference point, 4s delay1.41.51.61.2-1.3
Delay disc. indifference point, 8s delay2.62.73.11.5-1.8
Delay discount exponential model param2.42.52.6-1.61.6
Delay discount hyperbolic model param2.32.42.6-1.51.6
Fecal boli incidents, locomotor time 11.11.21.5-0.91.2
Change in fecal boli incidents, locomotor task0.10.10.20.1-0.4
Time >=10cm from walls, locomotor time 10.70.70.80.9-0.8
Bouts of movement, locomotor time 10.40.50.8-0.40.9
Total resting periods, locomotor time 10.30.30.6-0.30.8
Rest time, locomotor task time 10.20.20.20.5-0.3
Distance moved, locomotor task time 10.80.91.2-1.10.8
Vertical activity count, locomotor time 10.70.81.1-1.00.7
Time >=10cm from walls, locomotor time 20.70.80.9-1.00.8
Bouts of movement, locomotor time 20.20.20.40.2-0.6
Total resting periods, locomotor time 20.50.50.80.5-0.9
Rest time, locomotor task time 20.00.00.1-0.2-0.1
Distance moved, locomotor task time 20.20.20.3-0.50.3
Vertical activity count, locomotor time 20.10.10.20.1-0.5
Weight adjusted by age0.30.40.4-0.60.7
Seeking ratio, delayed vs. immediate footshock2.02.32.31.5-1.5
Locomotion in novel chamber0.10.10.10.3-0.4
Locomotion in novel chamber post-restriction0.30.40.6-0.80.3
Progressive ratio1.72.03.8-1.90.5
Food seeking constrained by brief footshock2.12.62.91.5-1.7
Seeking ratio, punishment vs. effort3.94.77.72.8-1.4
Run reversals in cocaine runway, females2.42.43.51.9-1.1
Run reversals in cocaine runway, males1.01.01.5-0.71.2
Latency to leave start box in cocaine runway0.80.81.0-1.00.8
Latency to leave start box in cocaine runway, F1.71.92.2-1.31.5
Latency to leave start box in cocaine runway, M0.30.20.50.1-0.7
Cd content in liver2.32.53.0-1.41.7
Co content in liver0.10.10.20.40.2
Cu content in liver4.85.86.1-2.52.3
Fe content in liver2.02.43.1-1.31.8
K content in liver1.81.82.2-1.51.2
Mg content in liver0.20.20.2-0.50.4
Mn content in liver0.30.30.6-0.8-0.0
Na content in liver0.30.40.4-0.60.6
Rb content in liver1.01.32.2-0.61.5
Se content in liver0.20.30.4-0.60.4
Sr content in liver0.00.00.1-0.2-0.0
Zn content in liver5.05.56.3-2.52.2