| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000000833 | 0.140 | 0.0830 | 4.7e-14 | 0.131 | 0.093 | 0.127 | 0.040 | 2.4e-14 | 1.8e-10 | 6.4e-14 | 2.5e-05 |
| 2 | BLA | gene expression | ENSRNOG00000000833 | 0.159 | 0.0934 | 1.3e-06 | 0.104 | 0.109 | 0.105 | 0.108 | 3.3e-06 | 2.0e-06 | 3.2e-06 | 2.2e-06 |
| 3 | Brain | gene expression | ENSRNOG00000000833 | 0.350 | 0.1100 | 0.0e+00 | 0.325 | 0.373 | 0.362 | 0.375 | 8.5e-31 | 3.1e-36 | 5.0e-35 | 1.6e-36 |
| 4 | IL | gene expression | ENSRNOG00000000833 | 0.346 | 0.1570 | 4.5e-06 | 0.160 | 0.173 | 0.148 | 0.155 | 1.2e-04 | 6.1e-05 | 2.1e-04 | 1.5e-04 |
| 5 | LHb | gene expression | ENSRNOG00000000833 | 0.224 | 0.1200 | 1.7e-04 | 0.169 | 0.151 | 0.185 | 0.160 | 8.1e-05 | 2.0e-04 | 3.6e-05 | 1.3e-04 |
| 6 | Liver | gene expression | ENSRNOG00000000833 | 0.069 | 0.0470 | 2.0e-06 | 0.042 | 0.041 | 0.043 | 0.044 | 1.7e-05 | 2.0e-05 | 1.3e-05 | 1.2e-05 |
| 7 | NAcc | gene expression | ENSRNOG00000000833 | 0.300 | 0.1300 | 0.0e+00 | 0.214 | 0.163 | 0.205 | 0.209 | 7.0e-16 | 3.3e-12 | 3.5e-15 | 1.7e-15 |
| 8 | OFC | gene expression | ENSRNOG00000000833 | 0.238 | 0.1232 | 3.0e-04 | 0.065 | 0.152 | 0.106 | 0.084 | 1.2e-02 | 1.9e-04 | 1.8e-03 | 5.1e-03 |
| 9 | PL | gene expression | ENSRNOG00000000833 | 0.317 | 0.1140 | 0.0e+00 | 0.278 | 0.233 | 0.269 | 0.150 | 2.5e-21 | 1.2e-17 | 1.5e-20 | 1.6e-11 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Context. condit. distance diff. score | 7.7 | 9.4 | 12.6 | 2.5 | 2.4 | 3.2 | 2.7 | 3.5 | 3.5 | 3.5 | 3.3 | 2.5 |
| Bone: final force | 7.0 | 11.4 | 12.7 | -3.3 | -3.2 | -3.6 | -3.4 | -3.5 | -3.0 | -3.5 | -3.6 | -3.3 |
| Bone: final moment | 6.2 | 10.3 | 11.4 | -3.2 | -3.1 | -3.4 | -3.2 | -3.2 | -2.9 | -3.3 | -3.4 | -3.2 |
| Body weight | 6.1 | 25.8 | 35.6 | -5.7 | -6.0 | -5.1 | -5.6 | -3.8 | -3.4 | -4.6 | -5.1 | -5.8 |
| Bone: maximum force | 5.7 | 9.9 | 10.7 | -3.1 | -3.2 | -3.2 | -3.2 | -3.0 | -2.8 | -3.2 | -3.3 | -3.2 |
| Progressive ratio | 5.2 | 6.1 | 6.9 | -2.6 | -2.5 | -2.5 | -2.5 | -1.9 | -2.4 | -2.6 | -2.6 | -2.5 |
| Bone: maximum moment | 5.1 | 8.9 | 9.7 | -3.0 | -3.1 | -3.1 | -3.1 | -2.7 | -2.6 | -3.0 | -3.1 | -3.1 |
| Bone: tissue strength | 5.1 | 5.0 | 5.4 | -2.2 | -2.3 | -2.3 | -2.2 | -2.0 | -2.3 | -2.3 | -2.3 | -2.2 |
| Locomotion velocity, session 7 | 4.6 | 5.1 | 5.8 | 2.4 | 2.2 | 2.4 | 2.4 | 2.2 | 1.7 | 2.2 | 2.3 | 2.4 |
| Bone: cortical thickness | 4.5 | 7.5 | 11.4 | -2.2 | -2.0 | -2.8 | -2.2 | -3.4 | -3.2 | -3.2 | -3.0 | -2.1 |
| Seeking ratio, punishment vs. effort | 4.5 | 5.6 | 6.3 | 2.4 | 2.5 | 2.3 | 2.4 | 1.8 | 2.4 | 2.4 | 2.5 | 2.5 |
| Epididymis fat weight | 4.1 | 9.5 | 21.8 | -1.3 | -0.8 | -3.0 | -1.6 | -4.7 | -4.5 | -3.9 | -3.4 | -1.4 |
| Locomotion distance, session 8 | 4.1 | 6.2 | 8.4 | 2.1 | 1.9 | 2.6 | 2.2 | 2.9 | 2.8 | 2.8 | 2.7 | 2.1 |
| Left kidney weight | 3.9 | 11.2 | 14.3 | -3.6 | -3.8 | -3.6 | -3.6 | -2.6 | -2.5 | -3.2 | -3.4 | -3.6 |
| Locomotion distance, session 7 | 3.9 | 4.9 | 6.2 | 2.5 | 2.5 | 2.3 | 2.5 | 1.7 | 1.8 | 1.9 | 2.2 | 2.5 |
| Cocaine response before conditioning | 3.7 | 4.5 | 7.6 | -2.7 | -2.8 | -2.1 | -2.6 | -1.2 | -0.8 | -1.4 | -1.9 | -2.7 |
| Short access day 1 locomotion | 3.7 | 3.9 | 4.7 | 2.2 | 2.1 | 2.0 | 2.0 | 1.6 | 1.8 | 1.9 | 2.0 | 2.1 |
| Condit. Reinf. lever presses | 3.7 | 5.0 | 8.0 | 1.7 | 1.6 | 2.4 | 1.8 | 2.7 | 2.8 | 2.5 | 2.4 | 1.7 |
| BMI without tail | 3.5 | 7.4 | 9.1 | -3.0 | -3.0 | -2.7 | -3.0 | -2.3 | -2.0 | -2.6 | -2.8 | -3.0 |
| Length with tail | 3.5 | 12.9 | 24.1 | -4.4 | -4.9 | -3.5 | -4.3 | -1.8 | -1.5 | -2.5 | -3.2 | -4.5 |
| Compulsive drug intake | 3.5 | 3.5 | 4.1 | 1.8 | 2.0 | 1.9 | 1.9 | 1.6 | 1.9 | 1.7 | 2.0 | 2.0 |
| Bone: trabecular spacing | 3.5 | 4.5 | 6.5 | -2.6 | -2.5 | -2.2 | -2.5 | -1.7 | -0.5 | -1.7 | -2.0 | -2.5 |
| Diff in mean of infusions in LGA sessions | 3.5 | 3.9 | 6.6 | 2.6 | 2.4 | 1.9 | 2.2 | 1.1 | 1.3 | 1.7 | 1.9 | 2.3 |
| Tail length | 3.4 | 10.3 | 21.4 | -4.1 | -4.6 | -2.8 | -4.1 | -1.2 | -0.8 | -1.8 | -2.6 | -4.2 |
| Intermitt. access escalation Index | 3.4 | 3.1 | 3.4 | 1.8 | 1.8 | 1.8 | 1.8 | 1.7 | 1.6 | 1.5 | 1.8 | 1.8 |
| Cocaine induced anxiety | 3.2 | 3.7 | 6.4 | 1.7 | 1.4 | 2.1 | 1.7 | 2.5 | 2.0 | 2.1 | 2.1 | 1.7 |
| Weight adjusted by age | 3.2 | 3.6 | 5.9 | -2.0 | -2.2 | -1.9 | -2.2 | -1.4 | -1.1 | -1.7 | -1.8 | -2.4 |
| Mg content in liver | 3.2 | 3.3 | 6.5 | 1.5 | 1.4 | 1.9 | 1.4 | 1.7 | 2.5 | 2.1 | 2.0 | 1.5 |
| Right kidney weight | 3.0 | 8.4 | 13.5 | -3.5 | -3.7 | -2.9 | -3.3 | -1.7 | -1.4 | -2.4 | -2.8 | -3.4 |
| Intermittent access standard deviation | 3.0 | 3.2 | 3.9 | -1.6 | -1.6 | -1.9 | -1.7 | -2.0 | -1.7 | -1.8 | -1.9 | -1.8 |
| Pavlov. Cond. response bias | 3.0 | 3.7 | 8.3 | 1.1 | 1.0 | 2.0 | 1.2 | 2.5 | 2.9 | 2.3 | 2.0 | 1.1 |
| Length without tail | 2.8 | 6.2 | 9.8 | -2.9 | -3.1 | -2.6 | -2.9 | -1.6 | -1.2 | -2.0 | -2.4 | -3.0 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.8 | 3.5 | 9.0 | 1.0 | 0.8 | 1.9 | 1.1 | 2.5 | 3.0 | 2.3 | 2.0 | 1.0 |
| Intermitt. access day 15 inactive lever presses | 2.7 | 2.9 | 3.9 | -1.9 | -1.8 | -1.7 | -1.8 | -1.6 | -1.0 | -2.0 | -1.8 | -1.8 |
| Stereotopy head waving duration, day 7 | 2.7 | 3.3 | 4.5 | -2.0 | -2.1 | -1.8 | -2.0 | -1.3 | -1.5 | -1.6 | -1.7 | -2.0 |
| Pavlov. Cond. magazine entry number | 2.7 | 3.4 | 6.5 | -1.3 | -1.2 | -1.9 | -1.4 | -2.3 | -2.6 | -2.1 | -1.9 | -1.3 |
| Mn content in liver | 2.7 | 3.1 | 9.1 | 0.8 | 0.7 | 1.7 | 0.8 | 2.1 | 3.0 | 2.3 | 1.9 | 0.8 |
| Parametrial fat weight | 2.6 | 5.2 | 6.7 | -2.3 | -2.3 | -2.3 | -2.1 | -1.8 | -2.3 | -2.6 | -2.3 | -2.3 |
| Pavlov. Cond. index score | 2.6 | 3.3 | 8.9 | 0.9 | 0.7 | 1.8 | 1.0 | 2.4 | 3.0 | 2.2 | 1.9 | 0.9 |
| Bone: connectivity density | 2.6 | 4.1 | 5.1 | 2.2 | 2.2 | 2.2 | 2.3 | 1.9 | 1.1 | 1.8 | 2.0 | 2.3 |
| Glucose | 2.4 | 3.7 | 13.1 | 0.6 | 0.4 | 1.8 | 0.7 | 2.4 | 3.6 | 2.4 | 2.0 | 0.6 |
| Indifference point AUC | 2.3 | 2.7 | 3.6 | -1.9 | -1.9 | -1.6 | -1.8 | -1.4 | -1.2 | -1.6 | -1.6 | -1.8 |
| Condit. Reinf. active-inactive response ratio | 2.3 | 2.5 | 3.7 | -1.9 | -1.9 | -1.6 | -1.9 | -1.2 | -0.7 | -1.2 | -1.4 | -1.9 |
| Time in familiar zone, hab. session 1 | 2.3 | 2.2 | 4.3 | 2.0 | 2.1 | 1.3 | 1.9 | 0.6 | 0.1 | 0.7 | 1.1 | 2.0 |
| Bone: cortical area | 2.3 | 3.5 | 4.1 | -2.0 | -2.0 | -1.9 | -2.0 | -1.8 | -1.3 | -1.8 | -1.9 | -2.0 |
| Delay disc. indifference point, 4s delay | 2.3 | 2.4 | 3.8 | -1.7 | -1.9 | -1.5 | -1.9 | -1.2 | -0.8 | -1.0 | -1.5 | -1.8 |
| Cu content in liver | 2.3 | 2.8 | 5.3 | 2.2 | 2.3 | 1.5 | 2.1 | 0.8 | 0.3 | 0.9 | 1.4 | 2.2 |
| Liver weight, right | 2.2 | 3.6 | 8.4 | -2.6 | -2.9 | -1.6 | -2.5 | -0.3 | 0.2 | -1.0 | -1.3 | -2.5 |
| Reaction time premature initiations | 2.2 | 3.1 | 4.9 | -1.6 | -1.3 | -1.9 | -1.6 | -2.2 | -1.5 | -2.1 | -1.9 | -1.5 |
| Incentive salience index mean | 2.2 | 2.6 | 3.8 | 1.3 | 1.1 | 1.8 | 1.3 | 1.9 | 1.9 | 1.8 | 1.7 | 1.3 |
| Bone: elastic work | 2.2 | 2.9 | 3.5 | -1.6 | -1.6 | -1.8 | -1.6 | -1.7 | -1.9 | -1.8 | -1.7 | -1.6 |
| BMI with tail | 2.1 | 6.7 | 7.9 | -2.6 | -2.5 | -2.7 | -2.6 | -2.5 | -2.2 | -2.8 | -2.8 | -2.6 |
| Pavlov. Cond. intertrial magazine entries | 2.1 | 2.7 | 4.2 | 1.3 | 1.1 | 1.7 | 1.3 | 1.9 | 2.1 | 1.9 | 1.8 | 1.2 |
| Stereotopy head waving bouts, day 7 | 2.1 | 2.4 | 3.1 | -1.7 | -1.8 | -1.6 | -1.6 | -1.2 | -1.4 | -1.4 | -1.5 | -1.7 |
| Pavlov. Cond. magazine entry latency | 2.1 | 2.7 | 6.0 | 0.9 | 0.7 | 1.7 | 1.0 | 2.3 | 2.5 | 2.0 | 1.8 | 0.9 |
| Area under the delay curve | 2.1 | 2.2 | 3.4 | -1.3 | -1.4 | -1.5 | -1.6 | -1.9 | -1.4 | -1.2 | -1.5 | -1.6 |
| Se content in liver | 2.1 | 2.5 | 7.4 | 0.8 | 0.5 | 1.5 | 0.8 | 2.0 | 2.7 | 2.0 | 1.7 | 0.8 |
| Bone: periosteal estimation | 2.0 | 4.2 | 7.6 | -2.7 | -2.8 | -1.9 | -2.6 | -1.0 | -0.1 | -1.2 | -1.7 | -2.7 |
| Bone: trabecular tissue density | 2.0 | 2.9 | 3.4 | -1.7 | -1.7 | -1.8 | -1.8 | -1.8 | -1.0 | -1.6 | -1.7 | -1.8 |
| Delay disc. indifference point, 16s delay | 2.0 | 2.0 | 5.0 | -0.7 | -0.8 | -1.4 | -1.1 | -2.2 | -1.9 | -1.2 | -1.6 | -1.1 |
| Delay discount exponential model param | 2.0 | 2.1 | 3.3 | 1.2 | 1.4 | 1.5 | 1.5 | 1.8 | 1.3 | 1.3 | 1.5 | 1.5 |
| Delay discount hyperbolic model param | 2.0 | 2.1 | 2.9 | 1.3 | 1.5 | 1.5 | 1.6 | 1.7 | 1.2 | 1.3 | 1.5 | 1.6 |
| Condit. Reinf. inactive responses | 1.9 | 2.2 | 3.2 | 1.7 | 1.7 | 1.6 | 1.8 | 1.3 | 0.6 | 1.2 | 1.3 | 1.7 |
| Pavlov. Cond. lever latency | 1.9 | 2.4 | 6.2 | -0.7 | -0.5 | -1.6 | -0.8 | -2.1 | -2.5 | -1.9 | -1.7 | -0.7 |
| Pavlov. Cond. latency score | 1.9 | 2.4 | 7.5 | 0.6 | 0.3 | 1.5 | 0.7 | 2.1 | 2.7 | 1.9 | 1.6 | 0.6 |
| Delay disc. indifference point, 2s delay | 1.9 | 2.1 | 2.9 | -1.7 | -1.6 | -1.5 | -1.7 | -1.5 | -0.5 | -1.3 | -1.3 | -1.6 |
| Latency to leave start box in cocaine runway, M | 1.9 | 1.8 | 2.8 | -1.1 | -1.2 | -1.5 | -1.3 | -1.7 | -1.0 | -1.6 | -1.4 | -1.2 |
| Co content in liver | 1.9 | 2.2 | 3.8 | -1.1 | -0.9 | -1.6 | -1.2 | -1.9 | -1.7 | -1.7 | -1.7 | -1.1 |
| Delay discounting water rate 24 sec | 1.8 | 2.5 | 3.0 | -1.7 | -1.7 | -1.6 | -1.6 | -1.4 | -0.9 | -1.7 | -1.6 | -1.7 |
| Tibia length | 1.7 | 4.9 | 9.2 | -2.9 | -3.0 | -2.1 | -2.9 | -1.0 | 0.1 | -1.2 | -1.8 | -2.9 |
| Reaction time mean AUC | 1.7 | 2.2 | 6.5 | 0.6 | 0.0 | 1.5 | 0.6 | 2.5 | 2.0 | 2.0 | 1.6 | 0.4 |
| Saline control response | 1.7 | 2.2 | 5.0 | -1.1 | -1.0 | -1.5 | -1.1 | -1.4 | -2.2 | -1.8 | -1.7 | -1.0 |
| Bouts of movement, locomotor time 1 | 1.7 | 1.8 | 3.5 | 1.2 | 0.9 | 1.4 | 1.2 | 1.9 | 1.0 | 1.8 | 1.4 | 1.1 |
| Reaction time mean | 1.6 | 2.3 | 6.1 | 0.6 | 0.1 | 1.5 | 0.7 | 2.5 | 2.1 | 2.0 | 1.6 | 0.4 |
| Condit. Reinf. inactive responses | 1.6 | 1.9 | 2.5 | 1.6 | 1.6 | 1.4 | 1.6 | 1.3 | 0.7 | 1.2 | 1.3 | 1.6 |
| Locomotion velocity, NPP test | 1.6 | 2.3 | 3.5 | 1.9 | 1.9 | 1.5 | 1.8 | 1.0 | 0.6 | 1.1 | 1.4 | 1.9 |
| Reaction time premature initiation rate | 1.5 | 2.0 | 2.6 | -1.4 | -1.3 | -1.4 | -1.5 | -1.6 | -0.9 | -1.6 | -1.4 | -1.4 |
| Locomotion distance, session 3 | 1.5 | 1.7 | 2.1 | 1.5 | 1.4 | 1.4 | 1.5 | 1.2 | 0.8 | 1.2 | 1.3 | 1.5 |
| Bone: stiffness | 1.5 | 2.3 | 3.0 | -1.4 | -1.4 | -1.6 | -1.4 | -1.6 | -1.5 | -1.7 | -1.7 | -1.4 |
| Time to tail flick, test, after self-admin | 1.5 | 1.5 | 3.7 | 1.0 | 0.6 | 1.5 | 1.1 | 1.9 | 0.8 | 1.5 | 1.3 | 0.9 |
| Delay discounting total patch changes 12 sec | 1.4 | 1.8 | 3.8 | -0.7 | -0.6 | -1.4 | -0.9 | -1.8 | -1.9 | -1.7 | -1.5 | -0.8 |
| Reaction time mean minus median | 1.4 | 1.8 | 7.2 | 0.2 | -0.5 | 1.1 | 0.3 | 2.7 | 1.7 | 1.8 | 1.2 | -0.1 |
| Degree of sensitization stereotypy | 1.4 | 1.5 | 1.9 | -1.3 | -1.4 | -1.3 | -1.3 | -1.0 | -1.2 | -1.2 | -1.2 | -1.3 |
| Condit. Reinf. active responses | 1.4 | 1.7 | 2.0 | 1.4 | 1.3 | 1.4 | 1.4 | 1.3 | 0.9 | 1.2 | 1.2 | 1.4 |
| Bone: endosteal estimation | 1.4 | 3.0 | 6.7 | -2.4 | -2.6 | -1.1 | -2.3 | 0.3 | 1.1 | -0.2 | -0.9 | -2.4 |
| Bone: marrow area | 1.4 | 2.9 | 6.6 | -2.4 | -2.6 | -1.1 | -2.3 | 0.2 | 1.0 | -0.2 | -0.9 | -2.4 |
| Conditioned reinforcement - inactives | 1.3 | 1.5 | 2.5 | -1.0 | -1.0 | -1.1 | -1.1 | -1.6 | -1.2 | -1.3 | -1.3 | -1.0 |
| Stereotopy head waving bouts, day 3 | 1.3 | 1.5 | 2.9 | -1.6 | -1.7 | -1.1 | -1.5 | -0.5 | -0.3 | -0.7 | -1.0 | -1.6 |
| Bone: cortical thickness | 1.3 | 1.5 | 3.3 | -0.6 | -0.4 | -1.2 | -0.7 | -1.8 | -1.8 | -1.6 | -1.4 | -0.6 |
| Delay discounting total patch changes 6 sec | 1.2 | 1.9 | 5.9 | -0.4 | -0.3 | -1.2 | -0.6 | -2.0 | -2.4 | -1.7 | -1.5 | -0.5 |
| Reaction time mean minus median AUC | 1.2 | 1.5 | 5.5 | 0.4 | -0.2 | 1.2 | 0.5 | 2.3 | 1.6 | 1.5 | 1.3 | 0.2 |
| Std. dev. reaction times | 1.2 | 1.6 | 5.7 | 0.1 | -0.6 | 1.1 | 0.1 | 2.4 | 1.8 | 1.7 | 1.2 | -0.2 |
| Condit. Reinf. active minus inactive responses | 1.2 | 1.5 | 2.0 | -1.4 | -1.4 | -1.2 | -1.4 | -1.0 | -0.8 | -1.0 | -1.2 | -1.4 |
| Post-drug Anxiety | 1.2 | 1.3 | 2.6 | 0.9 | 0.9 | 1.1 | 0.9 | 1.5 | 1.6 | 1.1 | 1.2 | 1.0 |
| Pavlov. Cond. lever contacts | 1.2 | 1.4 | 5.2 | 0.2 | 0.0 | 1.1 | 0.3 | 1.7 | 2.3 | 1.5 | 1.2 | 0.2 |
| Time to tail flick, vehicle, after self-admin | 1.2 | 1.3 | 2.8 | 0.8 | 0.5 | 1.2 | 0.8 | 1.7 | 1.5 | 1.2 | 1.3 | 0.8 |
| Delta time to tail flick, test, before/after SA | 1.2 | 1.1 | 1.5 | 1.0 | 1.0 | 1.2 | 1.1 | 1.2 | 0.6 | 1.1 | 1.0 | 1.1 |
| Rest time, locomotor task time 2 | 1.2 | 1.4 | 5.1 | -0.1 | -0.2 | 0.9 | 0.3 | 2.2 | 1.8 | 1.5 | 1.2 | 0.4 |
| Distance moved, locomotor task time 2 | 1.2 | 1.3 | 3.7 | -0.8 | -0.4 | -1.2 | -0.7 | -1.9 | -1.4 | -1.3 | -1.2 | -0.7 |
| Median of all reaction times | 1.1 | 1.6 | 3.5 | 0.6 | 0.2 | 1.3 | 0.6 | 1.9 | 1.8 | 1.7 | 1.3 | 0.5 |
| Reaction time omissions | 1.1 | 1.4 | 4.4 | 0.3 | -0.1 | 1.2 | 0.4 | 2.1 | 1.8 | 1.5 | 1.2 | 0.3 |
| Total zone transitions, NPP test | 1.1 | 1.6 | 2.0 | 1.4 | 1.3 | 1.4 | 1.4 | 1.2 | 0.7 | 1.2 | 1.3 | 1.4 |
| Bone: apparent density | 1.1 | 1.7 | 2.8 | 1.7 | 1.7 | 1.3 | 1.7 | 0.8 | -0.0 | 0.8 | 1.1 | 1.7 |
| Bone: trabecular number | 1.1 | 1.7 | 2.9 | 1.7 | 1.6 | 1.3 | 1.7 | 0.8 | -0.3 | 0.8 | 1.1 | 1.7 |
| Breakpoint value in progressive ratio session | 1.1 | 1.2 | 1.6 | 1.2 | 1.3 | 1.1 | 1.1 | 0.7 | 1.1 | 1.1 | 1.2 | 1.1 |
| Delta distance traveled before/after self-admin | 1.1 | 1.2 | 1.4 | -0.8 | -1.2 | -1.1 | -1.2 | -1.0 | -1.1 | -1.2 | -1.2 | -1.2 |
| Time in closed arm after self-admin | 1.1 | 1.1 | 2.2 | -0.8 | -0.7 | -1.2 | -0.9 | -1.5 | -1.1 | -1.1 | -1.1 | -0.9 |
| Delay discounting total patch changes 0 sec | 1.0 | 1.6 | 4.5 | -0.4 | -0.5 | -1.2 | -0.7 | -1.7 | -2.1 | -1.5 | -1.5 | -0.7 |
| Stereotopy head waving duration, day 3 | 1.0 | 1.2 | 1.9 | -1.4 | -1.4 | -1.0 | -1.3 | -0.7 | -0.4 | -0.7 | -0.9 | -1.4 |
| Locomotion velocity, session 8 | 1.0 | 1.1 | 3.4 | -0.2 | -0.4 | 0.8 | -0.0 | 1.6 | 1.8 | 1.5 | 1.1 | -0.2 |
| Time in novel zone, hab. session 1 | 1.0 | 1.0 | 2.2 | -1.4 | -1.5 | -0.8 | -1.3 | -0.2 | -0.0 | -0.3 | -0.7 | -1.4 |
| Locomotion velocity, hab. session 2 | 1.0 | 1.4 | 2.0 | 1.4 | 1.4 | 1.2 | 1.3 | 0.7 | 0.8 | 0.9 | 1.1 | 1.4 |
| Bone: cortical apparent density | 1.0 | 1.3 | 3.1 | -0.5 | -0.4 | -1.1 | -0.6 | -1.6 | -1.8 | -1.4 | -1.3 | -0.5 |
| Time in open arm after self-admin | 1.0 | 1.1 | 2.0 | 1.0 | 0.7 | 1.2 | 0.9 | 1.4 | 0.9 | 1.3 | 1.1 | 0.9 |
| Total resting periods, locomotor time 1 | 1.0 | 1.1 | 2.6 | 0.8 | 0.5 | 1.1 | 0.8 | 1.5 | 0.8 | 1.6 | 1.1 | 0.7 |
| Rb content in liver | 1.0 | 1.2 | 1.6 | 1.2 | 1.3 | 1.1 | 1.2 | 0.8 | 0.9 | 1.0 | 1.1 | 1.2 |
| Intraocular pressure | 0.9 | 1.3 | 2.3 | 1.2 | 1.1 | 1.2 | 1.3 | 1.5 | 0.4 | 0.9 | 1.1 | 1.2 |
| Times rat made contact with spout | 0.9 | 1.0 | 1.8 | 1.4 | 1.4 | 0.8 | 1.3 | 0.4 | -0.6 | 0.3 | 0.6 | 1.4 |
| Mean time between licks in bursts | 0.9 | 1.3 | 4.4 | 0.0 | -0.2 | 0.9 | 0.2 | 1.7 | 2.1 | 1.5 | 1.1 | 0.1 |
| Delay discounting total patch changes 18 sec | 0.9 | 1.2 | 4.9 | -0.1 | 0.2 | -0.7 | -0.1 | -1.4 | -2.2 | -1.4 | -1.1 | -0.0 |
| Progressive ratio test 2 breakpoint | 0.9 | 1.0 | 1.6 | 1.3 | 1.2 | 1.1 | 1.2 | 0.7 | 0.2 | 0.8 | 0.9 | 1.2 |
| Condit. Reinf. active minus inactive responses | 0.9 | 1.0 | 1.2 | 1.0 | 1.0 | 1.1 | 1.0 | 1.0 | 0.8 | 1.0 | 1.0 | 1.0 |
| Total locomotion distance, hab. session 2 | 0.9 | 1.2 | 1.8 | 1.3 | 1.4 | 1.1 | 1.3 | 0.6 | 0.6 | 0.9 | 1.0 | 1.3 |
| Total locomotion distance, NPP test | 0.9 | 1.3 | 2.0 | 1.4 | 1.4 | 1.1 | 1.4 | 0.7 | 0.3 | 0.8 | 1.0 | 1.4 |
| Bone: trabecular thickness | 0.9 | 1.1 | 1.8 | 1.3 | 1.3 | 1.1 | 1.3 | 0.8 | 0.1 | 0.7 | 0.9 | 1.3 |
| Distance moved, locomotor task time 1 | 0.9 | 0.9 | 1.8 | -0.9 | -0.7 | -1.0 | -0.8 | -1.3 | -1.0 | -0.9 | -1.0 | -0.8 |
| Intermittent access intake day 1-15 change | 0.8 | 0.8 | 1.2 | -0.8 | -1.1 | -0.9 | -0.8 | -0.5 | -1.1 | -0.8 | -0.9 | -0.9 |
| Incentive Sensitization - Breakpoint | 0.8 | 0.8 | 1.1 | 1.0 | 0.9 | 0.9 | 1.0 | 0.8 | 0.3 | 0.7 | 0.9 | 1.0 |
| Bone: cortical tissue density | 0.8 | 1.0 | 2.6 | -0.4 | -0.3 | -1.0 | -0.5 | -1.4 | -1.6 | -1.3 | -1.1 | -0.5 |
| Bone: periosteal perimeter | 0.8 | 1.3 | 2.7 | -1.6 | -1.6 | -0.9 | -1.5 | -0.2 | 0.6 | -0.3 | -0.7 | -1.6 |
| Indifference point 0 sec | 0.7 | 1.1 | 3.6 | -0.3 | -0.3 | -1.0 | -0.5 | -1.4 | -1.9 | -1.3 | -1.2 | -0.5 |
| Delay discounting total patch changes 24 sec | 0.7 | 0.9 | 3.0 | 1.0 | 1.1 | 0.1 | 0.8 | -0.8 | -1.7 | -0.9 | -0.2 | 0.8 |
| Locomotor activity | 0.7 | 1.1 | 2.9 | -1.4 | -1.7 | -0.6 | -1.3 | 0.6 | 0.4 | -0.0 | -0.5 | -1.4 |
| Reaction time num false alarms AUC | 0.7 | 0.9 | 1.7 | -1.1 | -1.1 | -0.9 | -1.1 | -1.0 | -0.3 | -0.7 | -0.8 | -1.3 |
| One hour access (0.3 mA shock) | 0.7 | 0.8 | 1.1 | 1.1 | 0.8 | 1.0 | 0.9 | 0.7 | 0.5 | 0.8 | 1.0 | 1.0 |
| Bone: cortical porosity | 0.7 | 0.8 | 1.3 | -0.7 | -0.7 | -1.0 | -0.8 | -1.1 | -0.9 | -1.0 | -0.9 | -0.7 |
| Bone: endosteal perimeter | 0.7 | 1.5 | 6.5 | -0.5 | -0.7 | 0.7 | -0.4 | 1.6 | 2.5 | 1.4 | 0.9 | -0.5 |
| Delta time to tail flick, vehicle, before/after SA | 0.7 | 0.7 | 1.1 | 0.8 | 0.8 | 0.9 | 0.9 | 1.0 | 0.6 | 0.7 | 0.9 | 0.8 |
| Fecal boli incidents, locomotor time 1 | 0.7 | 0.7 | 1.1 | 0.7 | 1.0 | 0.9 | 1.0 | 0.9 | 0.8 | 0.4 | 0.9 | 0.9 |
| Run reversals in cocaine runway, males | 0.7 | 0.7 | 1.7 | -1.3 | -1.3 | -0.0 | -0.8 | 1.0 | 0.6 | 0.0 | -0.0 | -1.0 |
| Cd content in liver | 0.7 | 0.8 | 1.9 | -0.6 | -0.6 | -0.8 | -0.6 | -0.9 | -1.4 | -1.0 | -1.0 | -0.6 |
| Fe content in liver | 0.7 | 0.8 | 1.8 | -0.6 | -0.5 | -1.0 | -0.6 | -0.9 | -1.3 | -1.2 | -1.0 | -0.6 |
| Std. dev. time between licks in bursts | 0.6 | 0.7 | 3.5 | -0.3 | -0.4 | 0.4 | -0.3 | 1.0 | 1.9 | 1.0 | 0.7 | -0.2 |
| Indifference point function ln k | 0.6 | 0.9 | 1.9 | 0.7 | 0.7 | 0.8 | 0.7 | 1.0 | 1.4 | 1.1 | 1.0 | 0.7 |
| Indifference point function log k | 0.6 | 0.9 | 1.9 | 0.7 | 0.7 | 0.8 | 0.7 | 1.0 | 1.4 | 1.1 | 1.0 | 0.7 |
| Incentive Sensitization - Responses | 0.6 | 0.6 | 0.9 | 1.0 | 0.9 | 0.8 | 0.9 | 0.6 | 0.3 | 0.6 | 0.8 | 0.9 |
| Progressive ratio test 2 active lever presses | 0.6 | 0.6 | 1.0 | 1.0 | 1.0 | 0.8 | 0.9 | 0.4 | 0.1 | 0.6 | 0.7 | 0.9 |
| Degree of sensitization distance | 0.6 | 0.6 | 2.1 | 0.5 | 0.5 | 0.7 | 0.5 | 0.6 | 1.4 | 0.9 | 0.8 | 0.5 |
| Total zone transitions, hab. session 1 | 0.6 | 0.8 | 1.1 | 1.0 | 1.0 | 0.9 | 1.0 | 0.7 | 0.6 | 0.8 | 0.9 | 1.0 |
| Bone: cortical porosity | 0.6 | 0.7 | 0.9 | -1.0 | -1.0 | -0.8 | -1.0 | -0.6 | -0.4 | -0.7 | -0.7 | -0.9 |
| Delay disc. indifference point, 24s delay | 0.6 | 0.6 | 1.7 | -0.4 | -0.4 | -0.8 | -0.7 | -1.3 | -0.6 | -0.9 | -0.9 | -0.7 |
| Change in fecal boli incidents, locomotor task | 0.6 | 0.5 | 1.1 | -0.6 | -0.7 | -0.8 | -0.9 | -1.1 | 0.2 | -0.6 | -0.6 | -0.7 |
| Vertical activity count, locomotor time 1 | 0.6 | 0.6 | 0.8 | -0.8 | -0.4 | -0.9 | -0.5 | -0.9 | -0.9 | -0.9 | -0.8 | -0.5 |
| Locomotion in novel chamber | 0.6 | 0.7 | 1.2 | -0.9 | -1.1 | -0.8 | -0.9 | -0.4 | -0.7 | -0.5 | -0.9 | -1.0 |
| Locomotion in novel chamber post-restriction | 0.6 | 0.8 | 1.0 | -0.8 | -0.8 | -0.9 | -0.9 | -1.0 | -0.9 | -0.7 | -1.0 | -0.8 |
| Soleus weight | 0.5 | 1.4 | 5.9 | -1.0 | -1.2 | 0.3 | -0.9 | 1.0 | 2.4 | 1.0 | 0.6 | -0.9 |
| Number of licking bursts | 0.5 | 0.5 | 1.3 | 0.4 | 0.4 | 0.7 | 0.4 | 0.8 | 1.2 | 1.0 | 0.9 | 0.5 |
| Food consumed during 24 hour testing period | 0.5 | 0.6 | 1.6 | -1.1 | -1.3 | -0.5 | -0.9 | 0.3 | -0.0 | -0.2 | -0.5 | -1.0 |
| Delay discounting water rate 0 sec | 0.5 | 0.8 | 1.0 | -0.9 | -0.9 | -0.9 | -0.9 | -0.9 | -0.8 | -0.9 | -0.9 | -1.0 |
| Light reinforcement 2 | 0.5 | 0.7 | 1.4 | -1.0 | -1.2 | -0.7 | -0.9 | -0.2 | -0.5 | -0.4 | -0.8 | -1.1 |
| Social time | 0.5 | 0.7 | 2.4 | -0.3 | -0.6 | 0.4 | -0.3 | 1.3 | 1.5 | 1.0 | 0.7 | -0.4 |
| Conditioned locomotion | 0.5 | 0.6 | 1.1 | -1.0 | -1.0 | -0.6 | -0.9 | -0.3 | -0.2 | -0.6 | -0.7 | -1.0 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.6 | 1.0 | -1.0 | -1.0 | -0.7 | -0.9 | -0.4 | -0.1 | -0.6 | -0.6 | -0.9 |
| Intermittent access intake escalation 2 | 0.5 | 0.5 | 1.5 | -0.0 | -0.6 | 0.4 | -0.1 | 1.2 | 1.0 | 0.8 | 0.6 | -0.2 |
| Intermittent access day 15 total locomotion | 0.5 | 0.6 | 1.6 | -0.9 | -1.2 | -0.5 | -0.9 | -0.1 | -0.4 | -0.2 | -0.6 | -1.0 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.5 | 1.4 | -0.8 | -0.9 | -0.1 | -0.7 | 0.5 | 1.2 | 0.3 | -0.0 | -0.8 |
| Bone: minimum diameter | 0.5 | 0.9 | 2.1 | -1.2 | -1.3 | -0.3 | -1.1 | 0.5 | 1.5 | 0.3 | -0.1 | -1.2 |
| Extinction: sum of active levers before priming | 0.5 | 0.5 | 1.0 | 0.9 | 1.0 | 0.6 | 0.7 | 0.0 | 0.5 | 0.4 | 0.6 | 0.8 |
| Time in open arm before self-admin | 0.5 | 0.5 | 1.3 | 0.5 | 0.2 | 0.9 | 0.5 | 1.1 | 0.6 | 1.0 | 0.8 | 0.3 |
| Retroperitoneal fat weight | 0.4 | 1.3 | 1.6 | -1.0 | -1.2 | -1.2 | -1.2 | -1.1 | -1.0 | -1.1 | -1.3 | -1.2 |
| Reaction time num false alarms | 0.4 | 0.6 | 1.2 | -0.9 | -0.9 | -0.7 | -0.9 | -0.7 | -0.2 | -0.5 | -0.6 | -1.1 |
| Cocaine response after cond. corrected | 0.4 | 0.5 | 0.8 | 0.8 | 0.9 | 0.7 | 0.8 | 0.2 | 0.6 | 0.5 | 0.7 | 0.8 |
| Condit. Reinf. lever presses | 0.4 | 0.5 | 0.7 | 0.8 | 0.9 | 0.8 | 0.8 | 0.6 | 0.6 | 0.6 | 0.7 | 0.8 |
| Conditioned reinforcement - actives | 0.4 | 0.4 | 1.1 | -0.6 | -0.5 | -0.7 | -0.7 | -1.0 | -0.3 | -0.7 | -0.6 | -0.6 |
| Intermittent access day 1 total infusions | 0.4 | 0.5 | 0.8 | 0.9 | 0.9 | 0.8 | 0.8 | 0.2 | 0.1 | 0.6 | 0.6 | 0.9 |
| Intermittent access day 1 locomotion | 0.4 | 0.4 | 0.7 | 0.6 | 0.4 | 0.8 | 0.5 | 0.8 | 0.5 | 0.7 | 0.6 | 0.5 |
| Short access day 1 total infusions | 0.4 | 0.4 | 0.7 | 0.7 | 0.8 | 0.6 | 0.6 | 0.3 | 0.8 | 0.6 | 0.6 | 0.7 |
| One hour access (shock baseline) | 0.4 | 0.5 | 1.1 | -0.7 | -1.1 | -0.6 | -0.8 | -0.2 | -0.8 | -0.6 | -0.7 | -0.8 |
| Total locomotion distance, hab. session 1 | 0.4 | 0.6 | 1.0 | 1.0 | 1.0 | 0.8 | 0.9 | 0.5 | 0.6 | 0.6 | 0.8 | 0.9 |
| Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 1.9 | 0.8 | 0.9 | 0.2 | 0.8 | -0.3 | -1.4 | -0.2 | -0.0 | 0.8 |
| Bone: maximum diameter | 0.4 | 0.7 | 1.5 | -1.1 | -1.2 | -0.3 | -1.0 | 0.3 | 1.1 | 0.2 | -0.1 | -1.1 |
| Bone: post-yield work | 0.4 | 0.5 | 1.6 | -0.1 | -0.2 | 0.7 | 0.0 | 1.3 | 1.1 | 0.9 | 0.6 | -0.1 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 0.8 | 0.8 | 0.9 | 0.7 | 0.7 | 0.1 | 0.5 | 0.4 | 0.6 | 0.6 |
| Delay disc. indifference point, 8s delay | 0.4 | 0.4 | 0.6 | -0.4 | -0.6 | -0.5 | -0.6 | -0.8 | -0.8 | -0.3 | -0.6 | -0.7 |
| Time >=10cm from walls, locomotor time 1 | 0.4 | 0.4 | 0.9 | -1.0 | -0.9 | -0.5 | -0.8 | 0.0 | 0.5 | -0.4 | -0.3 | -0.7 |
| Bouts of movement, locomotor time 2 | 0.4 | 0.4 | 1.4 | -0.8 | -1.2 | -0.3 | -0.7 | 0.6 | 0.0 | 0.0 | -0.2 | -0.9 |
| Total resting periods, locomotor time 2 | 0.4 | 0.4 | 1.1 | -0.5 | -1.0 | 0.1 | -0.5 | 1.0 | 0.5 | 0.4 | 0.2 | -0.6 |
| Seeking ratio, delayed vs. immediate footshock | 0.4 | 0.5 | 0.9 | -1.0 | -0.8 | -0.6 | -0.8 | -0.6 | -0.4 | -0.4 | -0.7 | -0.9 |
| Sr content in liver | 0.4 | 0.4 | 0.7 | -0.8 | -0.8 | -0.5 | -0.8 | -0.4 | 0.4 | -0.3 | -0.4 | -0.8 |
| Liver weight, left | 0.3 | 0.4 | 1.2 | -0.9 | -1.1 | -0.2 | -0.8 | 0.5 | 0.2 | 0.0 | -0.3 | -0.9 |
| Mean num. licks in bursts | 0.3 | 0.4 | 2.2 | 0.3 | 0.3 | -0.3 | 0.3 | -0.4 | -1.5 | -0.7 | -0.6 | 0.2 |
| Locomotor testing rearing | 0.3 | 0.4 | 1.1 | -0.9 | -1.0 | -0.5 | -0.8 | 0.2 | -0.0 | -0.3 | -0.4 | -0.8 |
| Reaction time number correct | 0.3 | 0.5 | 1.3 | -0.1 | 0.1 | -0.7 | -0.2 | -1.1 | -1.1 | -1.0 | -0.8 | -0.1 |
| Reaction time trials correct on left | 0.3 | 0.5 | 1.3 | -0.1 | 0.1 | -0.7 | -0.2 | -1.1 | -1.1 | -1.0 | -0.8 | -0.1 |
| Reaction time trials on left | 0.3 | 0.5 | 1.2 | -0.2 | 0.1 | -0.7 | -0.2 | -1.1 | -1.0 | -1.0 | -0.7 | -0.1 |
| Reaction time false alarm rate | 0.3 | 0.4 | 1.0 | -0.8 | -0.9 | -0.4 | -0.8 | -0.2 | 0.4 | -0.0 | -0.2 | -1.0 |
| Reaction time trials completed | 0.3 | 0.5 | 1.2 | -0.2 | 0.1 | -0.7 | -0.2 | -1.1 | -1.0 | -1.0 | -0.7 | -0.1 |
| Reaction time trials AUC | 0.3 | 0.4 | 1.1 | -0.1 | 0.1 | -0.6 | -0.1 | -1.0 | -1.0 | -0.9 | -0.7 | -0.1 |
| Pavlov. Cond. change in total contacts | 0.3 | 0.4 | 0.7 | -0.5 | -0.5 | -0.6 | -0.5 | -0.7 | -0.9 | -0.8 | -0.7 | -0.4 |
| Pavlov. Cond. magazine entry number | 0.3 | 0.4 | 0.6 | 0.8 | 0.8 | 0.6 | 0.7 | 0.4 | 0.4 | 0.7 | 0.6 | 0.7 |
| Intermittent access total locomotion | 0.3 | 0.3 | 1.0 | -0.7 | -1.0 | -0.3 | -0.7 | 0.1 | -0.3 | -0.1 | -0.4 | -0.7 |
| Short access total locomotion | 0.3 | 0.3 | 0.9 | 0.4 | 0.5 | 0.4 | 0.3 | 0.3 | 1.0 | 0.6 | 0.5 | 0.4 |
| Locomotion velocity, session 1 | 0.3 | 0.3 | 0.8 | 0.3 | 0.2 | 0.6 | 0.4 | 0.9 | 0.5 | 0.7 | 0.6 | 0.3 |
| Locomotion distance, session 2 | 0.3 | 0.4 | 0.5 | 0.7 | 0.6 | 0.7 | 0.7 | 0.5 | 0.3 | 0.4 | 0.6 | 0.7 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 0.6 | -0.6 | -0.7 | -0.5 | -0.6 | -0.2 | -0.8 | -0.3 | -0.5 | -0.6 |
| Bone: elastic displacement | 0.3 | 0.4 | 1.6 | -0.2 | -0.2 | -0.6 | -0.2 | -0.6 | -1.3 | -0.7 | -0.6 | -0.2 |
| Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 0.6 | -0.5 | -0.8 | -0.6 | -0.7 | -0.4 | -0.3 | -0.6 | -0.6 | -0.7 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 0.7 | -0.8 | -0.7 | -0.5 | -0.7 | -0.5 | -0.0 | -0.1 | -0.4 | -0.7 |
| Rest time, locomotor task time 1 | 0.3 | 0.3 | 1.5 | -0.1 | -0.3 | 0.4 | -0.0 | 1.2 | 0.7 | 0.5 | 0.4 | -0.0 |
| Run reversals in cocaine runway, females | 0.3 | 0.3 | 1.4 | -0.1 | -0.1 | -0.5 | -0.1 | -0.8 | -1.2 | -0.6 | -0.6 | -0.1 |
| Latency to leave start box in cocaine runway, F | 0.3 | 0.3 | 0.6 | 0.4 | 0.5 | 0.5 | 0.5 | -0.0 | 0.8 | 0.3 | 0.6 | 0.6 |
| Delay discounting time to switch 0 sec | 0.2 | 0.3 | 0.9 | 0.8 | 0.9 | 0.2 | 0.7 | -0.2 | -0.4 | -0.1 | 0.1 | 0.9 |
| Delay discounting water rate 18 sec | 0.2 | 0.3 | 0.6 | -0.6 | -0.7 | -0.3 | -0.6 | -0.1 | -0.5 | -0.2 | -0.5 | -0.7 |
| Light reinforcement 1 | 0.2 | 0.3 | 0.9 | 0.0 | -0.1 | -0.6 | -0.3 | -1.0 | -0.9 | -0.7 | -0.6 | -0.3 |
| Social responses | 0.2 | 0.2 | 0.4 | -0.2 | -0.3 | -0.6 | -0.5 | -0.6 | 0.3 | -0.2 | -0.4 | -0.5 |
| Pavlov. Cond. lever latency | 0.2 | 0.2 | 0.4 | -0.6 | -0.6 | -0.5 | -0.6 | -0.4 | -0.2 | -0.3 | -0.4 | -0.6 |
| Intermittent access intake escalation | 0.2 | 0.2 | 0.8 | -0.5 | -0.9 | -0.4 | -0.5 | 0.2 | -0.4 | -0.2 | -0.3 | -0.5 |
| Intermitt. access day 1 inactive lever presses | 0.2 | 0.2 | 0.7 | -0.5 | -0.5 | -0.2 | -0.5 | 0.1 | 0.8 | -0.1 | -0.1 | -0.4 |
| Baseline Anxiety | 0.2 | 0.3 | 1.0 | -0.2 | 0.3 | -0.6 | -0.2 | -1.0 | -0.1 | -0.7 | -0.5 | -0.1 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.3 | 0.6 | 0.6 | 0.4 | 0.4 | 0.0 | 0.1 | 0.4 | 0.4 | 0.5 |
| Progressive ratio test 1 breakpoint | 0.2 | 0.2 | 0.3 | 0.5 | 0.6 | 0.3 | 0.4 | -0.1 | 0.1 | 0.3 | 0.3 | 0.5 |
| Progressive ratio test 2 inactive lever presses | 0.2 | 0.3 | 0.5 | -0.6 | -0.7 | -0.5 | -0.6 | -0.4 | -0.4 | -0.5 | -0.5 | -0.6 |
| Short access day 1 total inactive lever presses | 0.2 | 0.3 | 1.3 | -0.3 | -0.5 | 0.2 | -0.3 | 0.6 | 1.1 | 0.4 | 0.3 | -0.3 |
| Short access day 10 total locomotion | 0.2 | 0.3 | 1.6 | -0.1 | -0.3 | 0.0 | -0.3 | 0.3 | 1.3 | 0.6 | 0.3 | -0.3 |
| Number of responses in last shaping day | 0.2 | 0.2 | 0.3 | -0.4 | -0.3 | -0.5 | -0.6 | -0.5 | 0.3 | -0.2 | -0.3 | -0.5 |
| Locomotion distance, session 1 | 0.2 | 0.3 | 0.6 | 0.8 | 0.7 | 0.4 | 0.7 | -0.1 | -0.5 | -0.0 | 0.3 | 0.8 |
| Locomotion velocity, session 3 | 0.2 | 0.2 | 0.8 | -0.1 | -0.1 | -0.4 | -0.1 | -0.5 | -0.9 | -0.5 | -0.5 | -0.1 |
| Locomotion velocity, hab. session 1 | 0.2 | 0.2 | 0.5 | 0.6 | 0.7 | 0.4 | 0.6 | 0.0 | 0.3 | 0.2 | 0.4 | 0.6 |
| Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.6 | 0.7 | 0.3 | 0.5 | -0.0 | 0.0 | 0.1 | 0.2 | 0.6 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.3 | -0.4 | -0.5 | -0.5 | -0.5 | -0.5 | -0.6 | -0.4 | -0.5 | -0.4 |
| Distance traveled before self-admin | 0.2 | 0.2 | 0.6 | 0.0 | -0.1 | 0.3 | 0.1 | 0.8 | 0.8 | 0.5 | 0.4 | 0.0 |
| Delta time in closed arm before/after self-admin | 0.2 | 0.2 | 0.6 | -0.5 | -0.3 | -0.5 | -0.5 | -0.8 | -0.3 | -0.3 | -0.4 | -0.5 |
| Time to tail flick, vehicle, before self-admin | 0.2 | 0.2 | 0.6 | 0.2 | 0.1 | 0.5 | 0.3 | 0.8 | 0.4 | 0.5 | 0.5 | 0.3 |
| Vertical activity count, locomotor time 2 | 0.2 | 0.2 | 1.0 | -0.1 | 0.2 | -0.5 | -0.1 | -1.0 | -0.6 | -0.5 | -0.5 | -0.1 |
| Latency to leave start box in cocaine runway | 0.2 | 0.2 | 0.8 | -0.3 | -0.2 | -0.3 | -0.3 | -0.9 | 0.3 | -0.7 | -0.2 | -0.2 |
| K content in liver | 0.2 | 0.2 | 0.3 | 0.4 | 0.5 | 0.4 | 0.4 | -0.0 | 0.6 | 0.5 | 0.4 | 0.4 |
| Heart weight | 0.1 | 0.2 | 0.3 | -0.4 | -0.4 | -0.5 | -0.5 | -0.5 | 0.1 | -0.1 | -0.3 | -0.5 |
| Extensor digitorum longus weight | 0.1 | 0.2 | 1.2 | -0.4 | -0.4 | 0.1 | -0.3 | 0.4 | 1.1 | 0.3 | 0.2 | -0.3 |
| Tibialis anterior weight | 0.1 | 0.3 | 0.9 | -0.0 | 0.2 | -0.4 | -0.0 | -1.0 | -0.8 | -0.9 | -0.6 | 0.1 |
| Delay discounting water rate 12 sec | 0.1 | 0.1 | 0.5 | 0.4 | 0.3 | 0.1 | 0.3 | -0.2 | -0.7 | -0.3 | -0.1 | 0.3 |
| Delay discounting water rate 6 sec | 0.1 | 0.2 | 0.8 | -0.1 | -0.0 | -0.3 | -0.0 | -0.4 | -0.9 | -0.5 | -0.3 | -0.1 |
| Locomotor testing distance | 0.1 | 0.1 | 0.3 | -0.5 | -0.5 | -0.1 | -0.4 | 0.3 | 0.3 | -0.0 | -0.1 | -0.4 |
| Social response proportion | 0.1 | 0.1 | 0.6 | 0.0 | -0.2 | -0.2 | -0.3 | 0.1 | 0.8 | 0.3 | 0.1 | -0.4 |
| Cocaine response after cond. not corrected | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.1 | -0.4 | -0.1 | 0.5 | 0.1 | -0.0 | -0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.2 | -0.4 | -0.3 | -0.3 |
| Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.3 | 0.3 | 0.4 | 0.1 | 0.4 | -0.1 | -0.6 | -0.2 | -0.0 | 0.4 |
| Intermittent access day 15 total infusions | 0.1 | 0.1 | 0.1 | 0.4 | 0.2 | 0.3 | 0.3 | 0.0 | -0.4 | 0.1 | 0.2 | 0.3 |
| Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | -0.1 | -0.2 | -0.2 | -0.2 | -0.5 | -0.5 | -0.3 | -0.3 | -0.2 |
| Progressive ratio test 1 inactive lever presses | 0.1 | 0.1 | 0.4 | 0.2 | 0.4 | -0.1 | 0.1 | -0.6 | -0.5 | -0.4 | -0.2 | 0.2 |
| Short access day 10 total inactive lever presses | 0.1 | 0.1 | 0.3 | -0.1 | -0.2 | 0.2 | -0.1 | 0.4 | 0.6 | 0.2 | 0.2 | -0.1 |
| Short access day 10 total infusions | 0.1 | 0.1 | 0.5 | -0.1 | -0.2 | -0.4 | -0.3 | -0.7 | -0.4 | -0.2 | -0.3 | -0.3 |
| Short access total infusions | 0.1 | 0.1 | 0.4 | -0.2 | -0.1 | -0.2 | -0.3 | -0.7 | 0.0 | -0.2 | -0.2 | -0.2 |
| Locomotion velocity, session 2 | 0.1 | 0.1 | 0.2 | -0.0 | -0.1 | 0.2 | -0.0 | 0.4 | 0.5 | 0.3 | 0.2 | -0.0 |
| Novel to familiar place preference ratio | 0.1 | 0.1 | 0.2 | -0.0 | -0.0 | -0.2 | -0.1 | -0.4 | -0.5 | -0.3 | -0.2 | -0.0 |
| Novelty place preference | 0.1 | 0.1 | 0.3 | -0.3 | -0.3 | -0.4 | -0.3 | -0.5 | -0.5 | -0.4 | -0.4 | -0.3 |
| Bone surface | 0.1 | 0.1 | 0.3 | -0.5 | -0.6 | -0.2 | -0.5 | -0.0 | -0.0 | -0.1 | -0.2 | -0.5 |
| Bone volume | 0.1 | 0.1 | 0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.3 | -0.6 | -0.5 | -0.4 | -0.3 |
| Distance traveled after self-admin | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | -0.2 | -0.5 | 0.1 | 0.2 | -0.0 | -0.3 | -0.6 |
| Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.4 | 0.4 | 0.3 | -0.0 | 0.2 | -0.6 | -0.5 | -0.1 | -0.1 | 0.1 |
| Time to tail flick, test, before self-admin | 0.1 | 0.1 | 0.5 | -0.1 | -0.2 | -0.2 | -0.1 | -0.4 | -0.7 | -0.4 | -0.3 | -0.2 |
| Ambulatory time after self-admin | 0.1 | 0.1 | 0.3 | -0.1 | -0.5 | -0.1 | -0.4 | 0.4 | 0.2 | -0.0 | -0.1 | -0.5 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.8 | -0.4 | -0.1 | -0.2 | -0.2 | 0.2 | 0.9 | -0.1 | 0.1 | -0.2 |
| Na content in liver | 0.1 | 0.1 | 0.4 | -0.2 | -0.2 | -0.4 | -0.2 | -0.7 | -0.2 | -0.4 | -0.3 | -0.2 |
| Zn content in liver | 0.1 | 0.1 | 0.7 | 0.1 | 0.1 | 0.1 | 0.0 | -0.0 | 0.9 | 0.1 | 0.2 | 0.1 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.0 | 0.2 | 0.4 | 0.2 | 0.2 | -0.0 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.1 | -0.0 | 0.1 | 0.0 | -0.0 |
| Condit. Reinf. lever reinforcers received | 0.0 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.2 | 0.3 | 0.2 | 0.3 | 0.2 | 0.2 |
| Pavlov. Cond. index score | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | -0.1 | -0.1 | -0.0 | 0.0 | -0.2 | -0.1 | -0.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | -0.1 | -0.1 | -0.0 | 0.0 | -0.2 | -0.1 | -0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | -0.2 | 0.0 | 0.1 | 0.3 |
| Conditioned locomotion | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | -0.0 | -0.1 | -0.1 | 0.3 | -0.0 | 0.0 | -0.1 |
| Intermittent access total infusions | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.1 | -0.2 | -0.4 | -0.1 | -0.0 | 0.2 |
| Lifetime Intake | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.1 | 0.1 | -0.3 | -0.2 | -0.1 | -0.0 | 0.1 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 | -0.2 | -0.3 | -0.1 | -0.2 | -0.2 | -0.1 |
| Condit. Reinf. active-inactive response ratio | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | -0.2 | -0.0 | -0.4 | -0.3 | -0.3 | -0.2 | 0.0 |
| Total zone transitions, hab. session 2 | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.1 | 0.1 | -0.4 | -0.3 | -0.2 | -0.1 | 0.1 |
| Delta time in open arm before/after self-admin | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | -0.0 | 0.0 | -0.3 | -0.1 | -0.2 | -0.0 |
| Time in closed arm before self-admin | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | -0.0 | 0.1 | -0.1 | 0.2 | -0.1 | 0.0 | 0.1 |
| Ambulatory time before self-admin | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | 0.1 | -0.0 | 0.4 | 0.2 | 0.3 | 0.0 | 0.0 |
| Total heroin consumption | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.1 | 0.2 | 0.0 | 0.1 | 0.2 | 0.2 |
| Food seeking constrained by brief footshock | 0.0 | 0.0 | 0.0 | -0.0 | 0.2 | 0.2 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.