Hub : Genes

Prrt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000000433	0.34	0.1	0.0e+00	0.26	0.35	0.35	0.35	1.7e-28	3.6e-40	7.7e-40	9.4e-41
2	Brain	gene expression	ENSRNOG00000000433	0.12	0.06	1.9e-09	0.1	0.09	0.09	0.1	1.7e-09	9.5e-09	8.1e-09	1.3e-09
3	Liver	gene expression	ENSRNOG00000000433	0.21	0.09	0.0e+00	0.14	0.15	0.14	0.15	1.4e-15	3.0e-16	8.9e-15	1.8e-16
4	NAcc	intron excision ratio	chr20:4120501:4121461	0.05	0.03	2.0e-03	0.04	0.02	0.02	0.02	7.3e-04	1.3e-02	1.3e-02	8.4e-03
5	PL	gene expression	ENSRNOG00000000433	0.11	0.07	1.5e-06	0.07	0.08	0.07	0.08	6.4e-06	1.1e-06	3.2e-06	1.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.4	4.7	11.5	-0.4	3.4	0.3	-3.0	1.8
BMI without tail	3.5	7.3	11.0	-3.3	1.8	-3.0	-1.6	3.2
Body weight	3.1	13.2	26.3	-2.1	5.1	-1.1	-4.7	3.5
Epididymis fat weight	1.2	2.7	5.7	0.1	2.4	0.5	-1.6	2.2
Glucose	1.2	1.8	5.9	0.9	-0.9	1.0	0.8	-2.4
Heart weight	1.3	1.8	4.0	-1.9	-0.1	-2.0	0.1	1.2
Left kidney weight	1.3	3.8	7.1	-1.3	2.7	-0.7	-2.4	2.0
Right kidney weight	1.6	4.7	7.6	-1.6	2.8	-1.3	-2.6	2.1
Tail length	2.9	8.8	18.0	-4.2	0.8	-4.1	-1.1	2.7
Length with tail	1.2	4.3	5.7	-2.4	1.9	-2.0	-2.0	2.0
Length without tail	1.2	2.6	6.6	0.3	2.6	0.8	-2.3	0.5
Liver weight, left	0.6	1.0	2.1	-0.6	1.4	-0.2	-1.4	0.8
Liver weight, right	0.8	1.4	2.8	-1.7	0.7	-1.5	-0.8	0.8
Parametrial fat weight	1.1	2.1	5.1	0.4	2.3	0.6	-2.0	1.0
Retroperitoneal fat weight	0.1	0.5	1.1	-0.1	1.0	0.1	-0.8	0.8
Intraocular pressure	0.3	0.5	1.1	1.1	0.0	0.8	0.0	-0.7
Extensor digitorum longus weight	0.0	0.1	0.3	0.3	0.5	0.2	-0.3	-0.5
Soleus weight	0.2	0.5	1.0	-0.2	1.0	0.0	-1.0	-0.6
Tibialis anterior weight	0.0	0.1	0.2	0.2	0.1	-0.1	0.1	0.4
Tibia length	1.3	3.6	6.9	-1.8	2.2	-1.1	-2.6	1.4
Number of licking bursts	0.1	0.1	0.4	0.0	-0.1	-0.1	0.3	-0.7
Food consumed during 24 hour testing period	0.8	1.0	2.4	0.5	1.5	0.8	-1.3	-0.1
Times rat made contact with spout	1.1	1.2	3.5	-0.2	-1.4	-0.5	1.9	0.4
Mean time between licks in bursts	0.2	0.3	1.2	-0.1	-0.7	-0.0	0.1	-1.1
Mean num. licks in bursts	0.3	0.4	1.0	-0.3	-0.5	-0.3	0.6	1.0
Std. dev. time between licks in bursts	0.2	0.2	0.5	-0.6	-0.2	-0.4	-0.4	-0.7
Water consumed over 24 hours	0.0	0.0	0.1	0.1	-0.0	0.2	0.0	-0.4
Indifference point 0 sec	1.6	2.6	6.1	-1.7	1.2	-1.5	-0.7	2.5
Indifference point AUC	1.5	1.8	3.9	-1.8	-0.1	-2.0	0.0	1.3
Indifference point function ln k	0.2	0.3	0.9	0.0	-0.7	-0.1	0.9	-0.4
Indifference point function log k	0.2	0.3	0.9	0.0	-0.7	-0.1	0.9	-0.4
Delay discounting total patch changes 0 sec	1.7	2.7	6.5	-1.7	1.2	-1.5	-0.6	2.6
Delay discounting total patch changes 12 sec	1.6	2.1	4.3	-1.6	0.7	-1.7	-0.5	2.1
Delay discounting total patch changes 18 sec	0.7	0.9	2.2	-0.1	1.3	-0.0	-0.8	1.5
Delay discounting total patch changes 24 sec	0.2	0.2	0.5	0.5	-0.2	0.4	0.7	0.4
Delay discounting total patch changes 6 sec	1.2	1.9	4.4	-1.4	1.0	-1.2	-0.6	2.1
Delay discounting time to switch 0 sec	1.6	2.5	4.1	1.7	1.7	2.0	-1.6	-0.3
Delay discounting water rate 0 sec	0.1	0.2	0.3	-0.5	0.4	-0.3	-0.0	0.5
Delay discounting water rate 12 sec	0.1	0.1	0.3	0.5	-0.1	0.2	0.6	-0.1
Delay discounting water rate 18 sec	0.1	0.2	0.4	-0.3	0.3	-0.3	0.2	0.7
Delay discounting water rate 24 sec	0.1	0.1	0.3	-0.1	0.5	-0.4	-0.1	0.4
Delay discounting water rate 6 sec	0.0	0.0	0.1	0.4	0.1	0.2	0.1	0.1
Locomotor activity	2.0	3.2	5.7	-2.4	0.7	-2.3	-0.8	1.9
Locomotor testing distance	0.8	1.3	2.0	-1.4	0.6	-1.4	-0.7	1.4
Locomotor testing rearing	0.6	1.0	2.1	-0.6	1.3	-0.4	-1.5	0.7
Light reinforcement 1	0.9	1.7	3.9	0.5	2.0	0.8	-1.9	0.6
Light reinforcement 2	1.0	1.3	2.5	0.8	1.6	1.1	-1.4	0.0
Reaction time number correct	0.6	0.9	1.5	-0.7	1.2	-0.3	-1.0	1.2
Reaction time mean minus median	0.9	1.2	2.8	0.8	-1.3	0.3	0.9	-1.7
Reaction time mean minus median AUC	2.0	2.6	5.1	1.4	-1.7	1.0	1.4	-2.2
Reaction time num false alarms	0.1	0.2	0.4	-0.6	-0.2	-0.6	-0.1	0.2
Reaction time num false alarms AUC	0.6	0.8	1.7	-1.3	-0.2	-1.3	-0.2	0.8
Reaction time trials correct on left	0.6	0.9	1.5	-0.7	1.2	-0.3	-1.0	1.2
Reaction time trials on left	0.6	0.9	1.4	-0.7	1.2	-0.4	-1.0	1.2
Reaction time mean	1.8	2.4	5.2	1.8	-0.8	1.7	0.5	-2.3
Reaction time mean AUC	1.8	2.4	4.9	1.8	-0.8	1.7	0.6	-2.2
Median of all reaction times	1.5	2.0	3.7	1.7	-0.3	1.9	0.0	-1.9
Reaction time omissions	0.7	1.0	2.6	1.0	-0.8	0.7	0.1	-1.6
Reaction time false alarm rate	0.5	0.7	1.2	-0.9	-1.0	-1.1	0.6	-0.0
Reaction time premature initiation rate	0.2	0.2	0.6	-0.2	0.6	0.1	-0.8	0.2
Reaction time premature initiations	0.8	1.1	2.0	-0.6	1.4	-0.2	-1.4	1.1
Std. dev. reaction times	0.8	1.1	2.2	0.4	-1.4	0.0	1.0	-1.5
Reaction time trials completed	0.6	0.9	1.4	-0.7	1.2	-0.4	-1.0	1.2
Reaction time trials AUC	0.6	0.8	1.5	-0.5	1.2	-0.2	-1.1	1.1
Social response proportion	0.4	0.5	0.9	-0.6	0.9	-0.3	-0.8	0.6
Social responses	0.7	0.9	1.5	-1.2	0.5	-0.9	-0.5	1.2
Social time	0.2	0.3	0.9	0.6	0.1	0.4	-0.4	-0.9
Conditioned locomotion	1.0	1.1	2.8	0.1	1.6	0.7	-1.7	0.2
Cocaine response after cond. corrected	2.3	2.6	5.0	2.0	1.0	2.2	-1.0	-1.3
Cocaine response after cond. not corrected	0.6	0.6	1.6	0.2	1.2	0.3	-1.2	-0.0
Cocaine response before conditioning	6.2	7.6	14.2	-3.7	0.7	-3.8	-0.8	2.9
Saline control response	3.1	4.2	7.6	-2.0	1.7	-1.9	-1.6	2.8
Condit. Reinf. active minus inactive responses	1.3	1.7	3.4	-1.8	-0.1	-1.8	-0.3	1.3
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.4	-1.8	0.3	-1.8	-0.5	1.1
Condit. Reinf. active responses	0.5	0.7	1.7	-1.1	-0.5	-1.3	-0.1	0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.4
Condit. Reinf. lever presses	0.6	0.8	1.6	-0.5	-1.3	-1.0	1.1	-0.0
Condit. Reinf. lever reinforcers received	0.6	0.9	2.0	-1.2	-0.8	-1.4	0.2	0.6
Pavlov. Cond. lever latency	0.3	0.5	1.0	0.4	1.0	0.6	-0.8	-0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	0.1	-0.8	-0.0	0.6	-0.6
Pavlov. Cond. change in total contacts	0.7	1.0	1.7	-1.1	-1.0	-1.3	0.9	0.6
Pavlov. Cond. index score	0.3	0.4	0.9	-0.5	-0.9	-0.7	0.8	0.0
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.6	-0.7	-0.7	0.5	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.4	-0.6	-0.6	0.6	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	-0.3	-0.8	-0.6	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.6	-0.5	-0.8	-0.6	0.7	0.1
Pavlov. Cond. response bias	0.4	0.5	1.3	-0.2	-1.1	-0.4	1.1	-0.0
Conditioned reinforcement - actives	0.0	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.5	-0.1	-0.4	0.3	0.6
Conditioned locomotion	0.3	0.4	0.7	0.6	-0.4	0.7	0.4	-0.8
Intermittent access intake day 1-15 change	0.6	0.6	1.0	-1.0	-0.4	-1.0	0.4	0.8
Intermittent access intake escalation	0.1	0.1	0.3	-0.5	-0.2	-0.5	0.1	0.2
Intermittent access intake escalation 2	0.5	0.5	1.0	0.2	-1.0	-0.1	0.7	-1.0
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.3	-0.3	1.4	-0.2	-1.5	0.2
Intermitt. access day 15 inactive lever presses	1.6	1.8	2.5	-1.6	0.8	-1.5	-0.9	1.6
Intermitt. access escalation Index	1.2	1.1	2.2	1.5	-0.2	1.2	0.1	-1.4
Intermittent access day 1 total infusions	1.7	2.0	2.5	1.3	-1.5	1.0	1.6	-1.5
Intermittent access day 15 total infusions	0.4	0.5	0.6	0.6	-0.8	0.4	0.8	-0.7
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	0.0	-0.8	-0.2	0.8	-0.3
Intermittent access total infusions	0.5	0.6	1.1	0.5	-1.0	0.4	1.0	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	-0.2	0.4	0.2	-0.4
Intermittent access day 15 total locomotion	0.4	0.5	0.7	-0.6	0.8	-0.4	-0.9	0.7
Intermittent access total locomotion	0.1	0.1	0.2	0.2	0.3	0.4	-0.3	-0.0
Intermittent access standard deviation	1.9	2.0	3.6	-1.4	1.3	-1.2	-1.2	1.9
Cocaine induced anxiety	1.2	1.4	3.0	1.7	0.3	1.5	-0.4	-1.3
Post-drug Anxiety	0.4	0.4	0.8	0.6	0.8	0.6	-0.9	-0.3
Baseline Anxiety	1.1	1.2	2.5	-1.6	0.2	-1.3	-0.3	1.2
Lifetime Intake	0.4	0.5	0.8	0.4	-0.9	0.4	0.9	-0.7
Incentive Sensitization - Responses	0.1	0.1	0.2	0.5	-0.5	-0.1	0.4	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	0.7	-0.4	0.1	0.3	-0.4
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	0.4	-0.8	0.5	0.8	-0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	0.3	-0.7	0.3	0.7	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.0	0.4	0.0	-0.4	0.3
Progressive ratio test 2 active lever presses	0.4	0.4	0.5	0.7	-0.7	0.4	0.7	-0.6
Progressive ratio test 2 breakpoint	0.7	0.7	1.0	1.0	-1.0	0.5	1.0	-0.8
Progressive ratio test 2 inactive lever presses	0.5	0.5	1.1	0.1	-1.1	-0.1	1.0	-0.7
Total sessions with >9 infusions	0.6	0.7	1.2	0.8	-0.6	0.9	0.7	-1.1
Short access day 1 total inactive lever presses	1.5	1.6	3.8	1.3	-0.9	1.2	0.8	-1.9
Short access day 10 total inactive lever presses	0.4	0.5	1.3	-0.1	1.0	-0.3	-1.1	0.2
Short access day 1 total infusions	1.4	1.5	2.6	0.5	-1.6	0.6	1.6	-1.4
Short access day 10 total infusions	0.1	0.1	0.1	0.2	-0.3	0.2	0.4	-0.4
Short access total infusions	0.5	0.5	1.1	0.0	-1.0	0.1	1.1	-0.6
Short access day 1 locomotion	0.9	1.0	2.0	1.1	-0.8	0.8	0.6	-1.4
Short access day 10 total locomotion	1.9	2.1	3.7	-1.9	1.0	-1.6	-1.4	1.2
Short access total locomotion	0.2	0.2	0.4	-0.5	0.5	-0.3	-0.6	0.2
Compulsive drug intake	0.5	0.5	1.1	0.9	0.2	0.6	-0.5	-1.0
One hour access (0.3 mA shock)	1.0	1.2	2.3	1.5	-0.6	1.0	0.5	-1.4
One hour access (shock baseline)	0.1	0.1	0.2	0.4	-0.4	0.3	0.5	-0.2
Number of responses in last shaping day	0.6	0.6	1.4	-1.1	-0.6	-1.2	0.5	-0.0
Context. condit. distance diff. score	4.1	5.0	11.1	2.3	-1.7	2.2	1.0	-3.3
Locomotion velocity, session 1	1.1	1.2	3.2	-0.2	-1.8	-0.4	1.2	-1.0
Locomotion distance, session 1	1.3	1.7	2.2	1.5	-1.1	1.4	0.9	-1.4
Locomotion velocity, session 2	0.4	0.4	0.9	0.3	-1.0	0.1	0.9	-0.6
Locomotion distance, session 2	2.1	3.0	5.0	2.2	-1.0	2.2	1.0	-1.8
Locomotion velocity, session 3	0.4	0.5	0.7	-0.8	-0.6	-0.8	0.5	0.8
Locomotion distance, session 3	2.3	2.5	4.1	1.4	-2.0	1.0	1.8	-1.5
Stereotopy head waving bouts, day 3	1.2	1.4	2.1	-1.4	1.1	-1.2	-1.1	1.1
Stereotopy head waving duration, day 3	1.9	2.4	4.6	-2.1	0.7	-1.9	-0.8	1.6
Locomotion velocity, session 7	6.8	7.4	11.2	3.4	-1.8	3.2	1.8	-3.1
Locomotion distance, session 7	6.1	7.8	9.9	2.9	-2.8	2.4	2.7	-3.2
Stereotopy head waving bouts, day 7	1.8	2.1	4.1	-1.9	-0.7	-2.0	0.8	1.2
Stereotopy head waving duration, day 7	1.5	1.9	3.7	-1.9	-0.0	-1.8	0.1	1.5
Locomotion velocity, session 8	0.4	0.5	1.5	0.1	-1.0	-0.1	0.4	-1.2
Locomotion distance, session 8	5.9	8.7	15.9	3.6	-1.5	3.4	1.0	-4.0
Degree of sensitization distance	0.1	0.1	0.3	0.3	0.1	0.2	-0.2	-0.6
Degree of sensitization stereotypy	1.5	1.6	2.6	-1.3	-1.3	-1.6	1.3	0.6
Condit. Reinf. active minus inactive responses	1.1	1.3	3.7	-0.2	-1.6	-0.4	1.9	-0.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.1	-1.0	-0.1	-0.9	0.7	1.0
Condit. Reinf. active responses	1.2	1.4	3.2	0.8	-1.5	0.6	1.8	-0.8
Condit. Reinf. inactive responses	2.4	2.9	4.5	2.1	-1.5	1.7	1.5	-1.6
Incentive salience index mean	1.8	2.2	3.3	1.2	-1.6	0.9	1.8	-1.7
Condit. Reinf. lever presses	3.2	4.3	8.1	2.5	-1.2	2.0	1.2	-2.9
Time in familiar zone, hab. session 1	1.4	1.3	2.9	0.6	-1.7	0.2	1.7	-0.5
Time in novel zone, hab. session 1	1.7	1.6	2.8	-1.1	1.7	-0.7	-1.7	0.9
Total zone transitions, hab. session 1	0.3	0.4	0.8	0.6	-0.7	0.5	0.3	-0.9
Total locomotion distance, hab. session 1	0.6	0.9	1.4	1.2	-0.7	1.0	0.3	-1.2
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.7	-0.8	0.6	0.4	-0.8
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.4	0.1	-0.7	-0.1	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.2	-0.4	-0.0	-0.0	0.0	0.1
Total zone transitions, hab. session 2	0.5	0.6	1.3	1.1	0.4	1.0	-0.5	-0.6
Total locomotion distance, hab. session 2	1.8	2.4	5.1	2.3	-0.2	2.0	-0.0	-1.7
Locomotion velocity, hab. session 2	2.1	2.8	5.7	2.4	-0.5	2.0	0.3	-2.0
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.1	-0.5	-0.1	0.7	-0.2
Novelty place preference	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.7	0.1
Time in novel zone, NPP test	0.4	0.4	0.6	-0.8	-0.5	-0.8	0.6	0.3
Total zone transitions, NPP test	1.9	2.8	4.6	2.1	-1.1	1.7	0.9	-2.2
Total locomotion distance, NPP test	3.3	4.6	8.6	2.9	-0.6	2.8	0.6	-2.5
Locomotion velocity, NPP test	4.4	6.3	11.8	3.4	-0.8	3.2	0.8	-2.9
Pavlov. Cond. lever latency	3.3	4.2	7.5	-1.2	2.7	-0.6	-2.1	2.7
Pavlov. Cond. magazine entry latency	1.7	2.2	4.8	-0.6	-2.2	-1.1	2.0	-0.8
Pavlov. Cond. change in total contacts	1.1	1.1	2.5	-0.6	-1.6	-1.0	1.3	-0.3
Pavlov. Cond. index score	2.4	3.0	6.4	0.5	-2.5	-0.1	2.2	-1.9
Pavlov. Cond. latency score	2.4	3.1	6.6	0.5	-2.6	-0.1	2.1	-2.0
Pavlov. Cond. lever contacts	2.7	3.2	6.4	1.3	-2.1	0.9	1.5	-2.5
Pavlov. Cond. magazine entry number	1.1	1.4	2.9	0.5	1.7	0.9	-1.6	0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.7	1.2	0.4	1.3	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	6.6	0.5	-2.6	-0.1	2.2	-1.9
Pavlov. Cond. response bias	1.7	2.1	4.8	0.2	-2.2	-0.2	1.9	-1.5
Bone: apparent density	1.7	2.9	5.0	2.2	-0.8	2.0	0.9	-2.0
Bone surface	0.1	0.1	0.3	0.1	0.6	0.0	-0.4	-0.4
Bone volume	0.1	0.2	0.3	0.5	0.4	0.5	-0.2	-0.5
Bone: connectivity density	2.1	3.3	6.1	2.5	-0.1	2.3	0.3	-2.2
Bone: cortical apparent density	0.8	1.0	1.9	-0.4	1.4	-0.2	-1.1	1.4
Bone: cortical area	0.5	0.7	0.9	-0.8	1.0	-0.9	-0.7	0.8
Bone: cortical porosity	3.0	3.2	5.1	-2.2	-1.5	-2.2	1.7	1.1
Bone: cortical porosity	3.0	3.2	5.6	-2.3	-1.4	-2.4	1.5	1.0
Bone: cortical thickness	0.5	0.8	1.7	-0.6	1.1	-0.6	-0.6	1.3
Bone: cortical thickness	0.7	0.8	2.0	-0.3	1.1	-0.1	-0.9	1.4
Bone: cortical tissue density	0.8	1.1	2.0	-0.5	1.3	-0.3	-1.2	1.4
Bone: elastic displacement	0.6	0.7	1.3	-0.6	-1.0	-0.7	1.1	0.4
Bone: elastic work	0.1	0.2	0.3	-0.5	0.2	-0.4	0.0	0.6
Bone: endosteal estimation	2.0	4.2	6.1	-2.5	1.8	-2.1	-2.1	1.7
Bone: endosteal perimeter	0.3	0.6	1.0	-0.8	1.0	-0.8	-1.0	0.0
Bone: final force	2.0	3.3	7.5	-0.7	2.7	-0.1	-2.3	1.8
Bone: final moment	1.5	2.5	5.5	-0.8	2.3	-0.2	-1.9	1.6
Bone: marrow area	2.2	4.8	6.7	-2.6	2.0	-2.2	-2.2	1.9
Bone: maximum diameter	0.1	0.1	0.3	-0.2	0.1	-0.5	-0.1	-0.5
Bone: maximum force	1.2	2.1	4.7	-0.8	2.2	-0.4	-1.8	1.4
Bone: maximum moment	0.9	1.6	3.2	-0.9	1.8	-0.5	-1.4	1.2
Bone: minimum diameter	0.4	0.7	1.1	-0.8	1.0	-0.7	-1.0	0.3
Bone: periosteal estimation	2.0	4.0	4.8	-2.2	2.0	-2.0	-2.0	1.8
Bone: periosteal perimeter	0.6	1.0	1.4	-1.2	1.0	-1.2	-0.9	0.7
Bone: post-yield work	0.3	0.4	1.0	-0.0	0.9	0.1	-1.0	-0.4
Bone: stiffness	0.8	1.3	3.6	-0.1	1.9	0.1	-1.5	0.9
Bone: tissue strength	0.3	0.3	0.6	0.5	0.5	0.8	-0.4	-0.2
Bone: trabecular number	2.4	3.8	6.2	2.5	-1.0	2.2	1.2	-2.3
Bone: trabecular spacing	2.6	3.3	4.9	-2.2	1.4	-1.9	-1.4	2.1
Bone: trabecular thickness	1.7	2.0	3.7	1.9	-0.7	1.8	0.6	-1.5
Bone: trabecular tissue density	1.4	1.9	4.2	-2.0	-0.4	-2.1	0.2	1.1
Breakpoint value in progressive ratio session	0.3	0.3	0.6	0.8	-0.2	0.5	0.3	-0.7
Distance traveled before self-admin	1.4	1.5	3.1	0.9	1.6	0.9	-1.8	-0.4
Distance traveled after self-admin	2.4	2.7	3.0	-1.7	1.5	-1.6	-1.7	1.7
Delta time in closed arm before/after self-admin	0.9	0.8	2.2	0.0	1.5	0.2	-1.4	0.2
Delta time in open arm before/after self-admin	0.4	0.4	1.0	-0.1	-1.0	-0.2	1.0	0.2
Diff in mean of infusions in LGA sessions	2.8	3.2	5.9	2.4	-0.8	2.0	1.0	-2.1
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.4	-0.3	0.3	0.5	-0.5
Active lever presses in extinction session 6	0.5	0.5	1.2	1.0	0.2	1.1	0.2	-0.4
Delta distance traveled before/after self-admin	3.7	3.9	7.4	-2.7	-0.4	-2.7	0.4	2.1
Delta ambulatory time before/after self-admin	2.6	2.9	5.6	-2.4	-0.4	-2.4	0.2	1.7
Time in closed arm before self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.1
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	0.4	0.1	-0.3	0.1
Time in open arm before self-admin	1.0	1.1	2.4	-0.5	-1.6	-0.7	1.5	-0.3
Time in open arm after self-admin	1.4	1.6	3.6	-0.7	-1.9	-0.9	1.7	-0.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.9	-0.1	-0.9	-0.1	0.9	-0.6
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	1.1	0.7	1.1	-0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.7	0.7	-0.2	0.6	-0.1	-0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.3
Time to tail flick, test, after self-admin	2.0	2.1	3.9	1.1	-2.0	0.5	1.7	-1.5
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	2.3	0.5	-1.5	0.5	1.3	-1.0
Delta time to tail flick, test, before/after SA	1.7	1.5	2.6	1.6	-0.6	1.6	0.4	-1.4
Ambulatory time before self-admin	0.5	0.6	0.8	0.9	0.7	0.8	-0.8	-0.6
Ambulatory time after self-admin	1.1	1.2	1.7	-1.3	0.7	-1.3	-0.9	1.1
Total heroin consumption	0.0	0.0	0.1	0.2	-0.1	0.1	0.2	-0.1
Area under the delay curve	0.4	0.5	0.9	-0.9	0.0	-0.7	0.4	0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.1	0.5	-0.1	-0.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	-0.5	-0.2	-0.4	0.6	0.7
Delay disc. indifference point, 2s delay	0.7	0.8	2.1	-1.5	-0.0	-1.0	0.2	0.9
Delay disc. indifference point, 24s delay	1.6	1.5	2.9	-1.7	-0.3	-1.5	0.6	1.4
Delay disc. indifference point, 4s delay	1.7	1.8	2.9	-1.7	0.8	-1.5	-0.5	1.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	-0.4	-0.3	-0.2	0.8	0.4
Delay discount exponential model param	0.7	0.7	1.4	1.2	0.1	0.9	-0.5	-1.1
Delay discount hyperbolic model param	0.9	1.0	1.9	1.4	0.1	1.2	-0.5	-1.2
Fecal boli incidents, locomotor time 1	0.7	0.7	1.5	0.9	-0.3	1.2	0.3	-1.0
Change in fecal boli incidents, locomotor task	0.7	0.7	1.1	-1.0	0.7	-1.1	-0.7	0.6
Time >=10cm from walls, locomotor time 1	2.6	2.6	6.6	0.0	2.6	0.5	-2.4	0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.2	-0.6	-0.1	0.6	-0.6
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.1	-0.6	-0.3	0.5	-0.6
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.5	-0.5	-0.6	-0.0	-0.2
Distance moved, locomotor task time 1	0.4	0.4	0.9	-0.2	0.9	0.1	-0.6	0.9
Vertical activity count, locomotor time 1	0.9	0.9	1.9	-0.3	1.4	0.2	-1.0	1.3
Time >=10cm from walls, locomotor time 2	1.1	1.2	2.5	-0.8	1.6	-0.2	-1.4	0.9
Bouts of movement, locomotor time 2	1.1	1.2	2.7	-1.4	-0.2	-1.7	0.2	1.0
Total resting periods, locomotor time 2	1.4	1.5	3.6	-1.6	-0.5	-1.9	0.3	0.8
Rest time, locomotor task time 2	0.6	0.7	1.3	0.8	0.5	0.7	-1.0	-1.1
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.1	0.7	0.6	-0.3	0.7
Vertical activity count, locomotor time 2	0.3	0.4	0.7	-0.1	0.8	0.4	-0.5	0.8
Weight adjusted by age	2.1	2.3	3.0	-1.7	1.6	-0.9	-1.7	1.4
Seeking ratio, delayed vs. immediate footshock	2.9	3.3	5.5	-2.2	0.7	-2.3	-0.7	2.3
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	0.0	-0.2	-0.3	0.4
Locomotion in novel chamber post-restriction	0.6	0.7	1.3	-0.4	1.1	-0.1	-1.2	0.8
Progressive ratio	6.1	7.1	10.7	-2.1	2.9	-1.8	-2.9	3.3
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.5	-0.2	-0.5	0.4	0.6
Seeking ratio, punishment vs. effort	3.1	3.8	6.5	1.0	-2.5	0.7	2.5	-2.1
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.6	-0.2	0.7	0.4	-0.0
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.1	-0.7	-0.0	0.6	-0.8
Latency to leave start box in cocaine runway	0.5	0.5	1.1	0.9	0.0	0.9	-0.1	-1.1
Latency to leave start box in cocaine runway, F	0.9	1.0	2.0	1.2	-0.4	1.2	0.4	-1.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.0	0.6	-0.2	-0.7	0.2
Cd content in liver	1.5	1.6	3.8	1.6	0.9	1.9	-0.7	-0.8
Co content in liver	1.8	2.1	3.9	-0.8	2.0	-0.4	-1.8	1.5
Cu content in liver	1.8	2.1	3.4	1.4	-1.8	1.0	1.8	-1.0
Fe content in liver	0.3	0.3	0.7	-0.2	0.8	0.1	-0.8	0.6
K content in liver	0.7	0.7	1.5	0.9	-0.7	0.6	0.5	-1.2
Mg content in liver	2.3	2.3	5.1	0.9	-1.9	0.2	1.4	-2.3
Mn content in liver	0.3	0.3	1.1	0.4	-0.5	0.3	0.3	-1.0
Na content in liver	0.1	0.1	0.2	0.3	-0.5	0.0	0.5	-0.3
Rb content in liver	1.2	1.6	2.6	1.6	0.4	1.5	-0.4	-1.6
Se content in liver	2.1	2.5	6.6	-0.4	-2.6	-0.8	2.0	-1.0
Sr content in liver	0.3	0.3	0.4	0.3	0.6	0.6	-0.6	-0.3
Zn content in liver	0.4	0.4	0.8	0.8	0.1	0.8	-0.2	-0.9