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Condit. Reinf. lever reinforcers received

Pavlovian Conditioned Approach, conditioned reinforcement, number of lever reinforcers received during the 40 min session

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

7 significantly associated models · 3 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	154277716	156447903	3	1	2.2e-07	2.2e-07	1	100	P2ry2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Tail length	3.2	3	0	0	1	5.1e-12	Mrpl48 P2ry2 Arap1
Mean time between licks in bursts	7.7	3	0	0	1	3.7e-13	Mrpl48 P2ry2 Arap1
Light reinforcement 1	4.1	3	0	0	-1	6.5e-12	Mrpl48 P2ry2 Arap1
Condit. Reinf. active minus inactive responses	13.2	3	0	0	1	8.4e-17	Mrpl48 P2ry2 Arap1
Condit. Reinf. active responses	17.5	3	0	0	1	7.0e-17	Mrpl48 P2ry2 Arap1
Condit. Reinf. inactive responses	11.2	3	0	0	1	6.0e-16	Mrpl48 P2ry2 Arap1
Condit. Reinf. lever presses	24.3	3	3	300	1	4.5e-15	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever latency	23.6	3	3	300	-1	8.0e-14	Mrpl48 P2ry2 Arap1
Pavlov. Cond. change in total contacts	19.1	3	3	300	1	4.6e-14	Mrpl48 P2ry2 Arap1
Pavlov. Cond. index score	16.3	3	0	0	1	1.6e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. latency score	14.6	3	0	0	1	2.9e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever contacts	24.7	3	3	300	1	1.9e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. magazine entry number	6.8	3	0	0	-1	3.3e-12	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever-magazine prob. diff.	15.2	3	0	0	1	2.5e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. response bias	23.3	3	3	300	1	2.0e-13	Mrpl48 P2ry2 Arap1
Time in open arm before self-admin	7.3	3	0	0	-1	7.5e-09	Mrpl48 P2ry2 Arap1

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	2	0.094	1.4
Adipose	alternative TSS	0	0.000	1.4
Adipose	gene expression	0	0.000	1.4
Adipose	isoform ratio	0	0.000	1.3
Adipose	intron excision ratio	0	0.000	1.2
Adipose	mRNA stability	1	0.029	1.4
BLA	alternative polyA	0	0.000	1.3
BLA	alternative TSS	0	0.000	1.6
BLA	gene expression	0	0.000	1.5
BLA	isoform ratio	0	0.000	1.3
BLA	intron excision ratio	0	0.000	1.4
BLA	mRNA stability	0	0.000	1.4
Brain	alternative polyA	0	0.000	1.4
Brain	alternative TSS	0	0.000	1.4
Brain	gene expression	0	0.000	1.4
Brain	isoform ratio	0	0.000	1.4
Brain	intron excision ratio	0	0.000	1.4
Brain	mRNA stability	0	0.000	1.5
Eye	alternative polyA	0	0.000	1.3
Eye	alternative TSS	0	0.000	1.3
Eye	gene expression	0	0.000	1.5
Eye	isoform ratio	0	0.000	1.8
Eye	intron excision ratio	0	0.000	1.5
Eye	mRNA stability	0	0.000	1.5
IL	alternative polyA	0	0.000	1.2
IL	alternative TSS	0	0.000	1.3
IL	gene expression	0	0.000	1.4
IL	isoform ratio	0	0.000	1.3
IL	intron excision ratio	0	0.000	1.4
IL	mRNA stability	0	0.000	1.4
LHb	alternative polyA	0	0.000	1.3
LHb	alternative TSS	0	0.000	1.2
LHb	gene expression	0	0.000	1.4
LHb	isoform ratio	0	0.000	1.3
LHb	intron excision ratio	0	0.000	1.3
LHb	mRNA stability	0	0.000	1.5
Liver	alternative polyA	4	0.266	1.5
Liver	alternative TSS	0	0.000	1.4
Liver	gene expression	0	0.000	1.4
Liver	isoform ratio	0	0.000	1.4
Liver	intron excision ratio	0	0.000	1.4
Liver	mRNA stability	0	0.000	1.5
NAcc	alternative polyA	0	0.000	1.4
NAcc	alternative TSS	0	0.000	1.4
NAcc	gene expression	0	0.000	1.5
NAcc	isoform ratio	0	0.000	1.4
NAcc	intron excision ratio	0	0.000	1.3
NAcc	mRNA stability	0	0.000	1.5
OFC	alternative polyA	0	0.000	1.2
OFC	alternative TSS	0	0.000	1.5
OFC	gene expression	0	0.000	1.4
OFC	isoform ratio	0	0.000	1.3
OFC	intron excision ratio	0	0.000	1.3
OFC	mRNA stability	0	0.000	1.5
PL	alternative polyA	0	0.000	1.3
PL	alternative TSS	0	0.000	1.6
PL	gene expression	0	0.000	1.4
PL	isoform ratio	0	0.000	1.4
PL	intron excision ratio	0	0.000	1.4
PL	mRNA stability	0	0.000	1.5

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.