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Condit. Reinf. lever reinforcers received

Pavlovian Conditioned Approach, conditioned reinforcement, number of lever reinforcers received during the 40 min session

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

2 loci · 2 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	154527801	156401577	2	1	2.19e-07	2.19e-07	2.24e-01	Relt
2	chr3	44152620	45549784	1	1	1.65e-07	3.22e-01	5.93e-11	Ly75

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	3.94	1	0	0	0	1e+00	Ly75
Epididymis fat weight	3.44	1	0	0	0	1e+00	Ly75
Glucose	3.95	1	0	0	0	1e+00	Ly75
Tail length	3.26	2	0	0	0	1e+00	Atg16l2 Relt
Length with tail	2.02	3	0	0	0	1e+00	Atg16l2 Ly75 Relt
Length without tail	8.83	1	0	0	0	1e+00	Ly75
Retroperitoneal fat weight	8.85	1	1	50	0	1e+00	Ly75
Extensor digitorum longus weight	1.63	1	0	0	0	1e+00	Ly75
Tibialis anterior weight	3.75	1	0	0	0	1e+00	Ly75
Number of licking bursts	7.94	1	0	0	0	1e+00	Ly75
Food consumed during 24 hour testing period	11.76	1	0	0	0	1e+00	Ly75
Mean time between licks in bursts	7.81	2	0	0	0	1e+00	Atg16l2 Relt
Mean num. licks in bursts	4.84	1	0	0	0	1e+00	Ly75
Water consumed over 24 hours	19.18	1	0	0	0	1e+00	Ly75
Patch foraging total patch changes 18 sec	13.09	1	0	0	0	1e+00	Ly75
Patch foraging time to switch 0 sec	4.18	2	0	0	0	1e+00	Atg16l2 Relt
Locomotor activity	6.86	1	0	0	0	1e+00	Ly75
Locomotor testing distance	6.84	1	0	0	0	1e+00	Ly75
Locomotor testing rearing	4.53	1	0	0	0	1e+00	Ly75
Light reinforcement 1	4.36	2	0	0	0	1e+00	Atg16l2 Relt
Reaction time mean minus median	5.26	1	0	0	0	1e+00	Ly75
Reaction time mean minus median AUC	17.14	1	0	0	0	1e+00	Ly75
Reaction time mean	9.87	1	0	0	0	1e+00	Ly75
Reaction time mean AUC	10.73	1	0	0	0	1e+00	Ly75
Median of all reaction times	5.14	1	0	0	0	1e+00	Ly75
Reaction time premature initiation rate	9.14	1	0	0	0	1e+00	Ly75
Reaction time premature initiations	4.53	1	0	0	0	1e+00	Ly75
Std. dev. reaction times	14.29	1	0	0	0	1e+00	Ly75
Cocaine response before conditioning	5.9	1	0	0	0	1e+00	Ly75
Saline control response	5.31	2	0	0	0	1e+00	Atg16l2 Relt
Condit. Reinf. active minus inactive responses	18.43	3	1	50	0	1e+00	Atg16l2 Ly75 Relt
Condit. Reinf. active-inactive response ratio	11.56	1	0	0	0	1e+00	Ly75
Condit. Reinf. active responses	20.13	3	1	50	0	1e+00	Atg16l2 Ly75 Relt
Condit. Reinf. inactive responses	11.52	2	0	0	0	1e+00	Atg16l2 Relt
Condit. Reinf. lever presses	19.38	3	2	100	0	1e+00	Atg16l2 Ly75 Relt
Pavlov. Cond. lever latency	24.09	2	2	100	0	1e+00	Atg16l2 Relt
Pavlov. Cond. change in total contacts	16.67	3	0	0	0	1e+00	Atg16l2 Ly75 Relt
Pavlov. Cond. index score	16.65	2	0	0	0	1e+00	Atg16l2 Relt
Pavlov. Cond. latency score	14.9	2	0	0	0	1e+00	Atg16l2 Relt
Pavlov. Cond. lever contacts	25.18	2	2	100	0	1e+00	Atg16l2 Relt
Pavlov. Cond. magazine entry number	6.8	2	0	0	0	1e+00	Atg16l2 Relt
Pavlov. Cond. lever-magazine prob. diff.	15.48	2	0	0	0	1e+00	Atg16l2 Relt
Pavlov. Cond. response bias	23.59	2	2	100	0	1e+00	Atg16l2 Relt
Locomotion velocity, session 1	6.3	1	0	0	0	1e+00	Ly75
Locomotion distance, session 3	14.48	1	0	0	0	1e+00	Ly75
Stereotopy head waving bouts, day 7	23.7	1	0	0	0	1e+00	Ly75
Stereotopy head waving duration, day 7	21.6	1	0	0	0	1e+00	Ly75
Degree of sensitization distance	10.32	1	0	0	0	1e+00	Ly75
Degree of sensitization stereotypy	16.6	3	1	50	0	1e+00	Atg16l2 Ly75 Relt
Condit. Reinf. active minus inactive responses	16.76	1	0	0	0	1e+00	Ly75
Condit. Reinf. active-inactive response ratio	9.84	1	0	0	0	1e+00	Ly75
Condit. Reinf. active responses	13.63	1	0	0	0	1e+00	Ly75
Incentive salience index mean	15.42	1	0	0	0	1e+00	Ly75
Total zone transitions, hab. session 1	7.48	1	0	0	0	1e+00	Ly75
Total zone transitions, hab. session 2	19.52	1	0	0	0	1e+00	Ly75
Total locomotion distance, hab. session 2	24.97	1	1	50	0	1e+00	Ly75
Locomotion velocity, hab. session 2	19.99	1	1	50	0	1e+00	Ly75
Total zone transitions, NPP test	5.39	1	0	0	0	1e+00	Ly75
Total locomotion distance, NPP test	4.87	1	0	0	0	1e+00	Ly75
Locomotion velocity, NPP test	4.37	1	0	0	0	1e+00	Ly75
Pavlov. Cond. latency score	6.68	1	0	0	0	1e+00	Ly75
Bone: apparent density	27.67	1	1	50	0	1e+00	Ly75
Bone surface	47.59	1	1	50	0	1e+00	Ly75
Bone volume	43.15	1	1	50	0	1e+00	Ly75
Bone: connectivity density	21.24	1	1	50	0	1e+00	Ly75
Bone: cortical apparent density	18.66	1	0	0	0	1e+00	Ly75
Bone: cortical area	12.58	1	0	0	0	1e+00	Ly75
Bone: cortical thickness	5.93	1	0	0	0	1e+00	Ly75
Bone: cortical thickness	7.09	1	0	0	0	1e+00	Ly75
Bone: cortical tissue density	17.88	1	0	0	0	1e+00	Ly75
Bone: elastic work	15.82	1	0	0	0	1e+00	Ly75
Bone: endosteal estimation	9.05	1	0	0	0	1e+00	Ly75
Bone: final force	35.73	1	1	50	0	1e+00	Ly75
Bone: final moment	48.32	1	1	50	0	1e+00	Ly75
Bone: marrow area	9.02	1	0	0	0	1e+00	Ly75
Bone: maximum diameter	5.12	1	0	0	0	1e+00	Ly75
Bone: maximum force	20.87	1	1	50	0	1e+00	Ly75
Bone: maximum moment	29.34	1	1	50	0	1e+00	Ly75
Bone: minimum diameter	8.69	1	0	0	0	1e+00	Ly75
Bone: periosteal estimation	14.82	1	1	50	0	1e+00	Ly75
Bone: periosteal perimeter	7.52	1	0	0	0	1e+00	Ly75
Bone: stiffness	8.72	1	0	0	0	1e+00	Ly75
Bone: trabecular number	35.45	1	1	50	0	1e+00	Ly75
Bone: trabecular spacing	60.24	1	1	50	0	1e+00	Ly75
Bone: trabecular thickness	47.42	1	1	50	0	1e+00	Ly75
Time in open arm before self-admin	7.9	2	0	0	0	1e+00	Atg16l2 Relt
Total resting periods, locomotor time 1	5.85	1	0	0	0	1e+00	Ly75
Rest time, locomotor task time 1	12.3	1	0	0	0	1e+00	Ly75
Distance moved, locomotor task time 1	13.8	1	0	0	0	1e+00	Ly75
Weight adjusted by age	20.87	1	0	0	0	1e+00	Ly75
Locomotion in novel chamber	34.01	1	1	50	0	1e+00	Ly75
Food seeking constrained by brief footshock	13.79	1	0	0	0	1e+00	Ly75
Seeking ratio, punishment vs. effort	5.43	1	0	0	0	1e+00	Ly75
Run reversals in cocaine runway, females	21.72	1	0	0	0	1e+00	Ly75
Cu content in liver	8.78	1	0	0	0	1e+00	Ly75
Fe content in liver	7.43	1	0	0	0	1e+00	Ly75
K content in liver	12.92	1	0	0	0	1e+00	Ly75
Mg content in liver	13.79	1	0	0	0	1e+00	Ly75
Mn content in liver	32.26	1	1	50	0	1e+00	Ly75
Na content in liver	12.24	1	0	0	0	1e+00	Ly75
Rb content in liver	4.86	1	0	0	0	1e+00	Ly75
Sr content in liver	14.16	1	0	0	0	1e+00	Ly75
Zn content in liver	12.81	1	0	0	0	1e+00	Ly75

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.37
Adipose	alternative TSS	0	0	1.48
Adipose	gene expression	0	0	1.43
Adipose	isoform ratio	0	0	1.37
Adipose	intron excision ratio	0	0	1.23
Adipose	mRNA stability	0	0	1.43
BLA	alternative polyA	0	0	1.41
BLA	alternative TSS	0	0	1.47
BLA	gene expression	0	0	1.46
BLA	isoform ratio	0	0	1.38
BLA	intron excision ratio	0	0	1.4
BLA	mRNA stability	0	0	1.41
Brain	alternative polyA	0	0	1.39
Brain	alternative TSS	0	0	1.44
Brain	gene expression	0	0	1.44
Brain	isoform ratio	1	0	1.42
Brain	intron excision ratio	0	0	1.38
Brain	mRNA stability	0	0	1.44
Eye	alternative polyA	0	0	1.05
Eye	alternative TSS	0	0	1.83
Eye	gene expression	0	0	1.54
Eye	isoform ratio	0	0	1.38
Eye	intron excision ratio	0	0	1.62
Eye	mRNA stability	0	0	1.44
IL	alternative polyA	0	0	1.39
IL	alternative TSS	0	0	1.38
IL	gene expression	0	0	1.41
IL	isoform ratio	0	0	1.36
IL	intron excision ratio	0	0	1.21
IL	mRNA stability	0	0	1.49
LHb	alternative polyA	0	0	1.39
LHb	alternative TSS	0	0	1.31
LHb	gene expression	1	0	1.38
LHb	isoform ratio	0	0	1.28
LHb	intron excision ratio	0	0	1.26
LHb	mRNA stability	0	0	1.42
Liver	alternative polyA	0	0	1.32
Liver	alternative TSS	0	0	1.43
Liver	gene expression	1	0	1.44
Liver	isoform ratio	0	0	1.35
Liver	intron excision ratio	0	0	1.35
Liver	mRNA stability	0	0	1.41
NAcc	alternative polyA	0	0	1.38
NAcc	alternative TSS	0	0	1.45
NAcc	gene expression	0	0	1.47
NAcc	isoform ratio	0	0	1.37
NAcc	intron excision ratio	0	0	1.33
NAcc	mRNA stability	0	0	1.47
OFC	alternative polyA	0	0	1.32
OFC	alternative TSS	0	0	1.32
OFC	gene expression	0	0	1.41
OFC	isoform ratio	0	0	1.29
OFC	intron excision ratio	0	0	1.17
OFC	mRNA stability	0	0	1.48
PL	alternative polyA	0	0	1.42
PL	alternative TSS	0	0	1.45
PL	gene expression	0	0	1.46
PL	isoform ratio	0	0	1.4
PL	intron excision ratio	0	0	1.4
PL	mRNA stability	0	0	1.48
pVTA	alternative polyA	0	0	1.39
pVTA	alternative TSS	0	0	1.46
pVTA	gene expression	0	0	1.46
pVTA	isoform ratio	0	0	1.37
pVTA	intron excision ratio	0	0	1.41
pVTA	mRNA stability	0	0	1.47
RMTg	alternative polyA	0	0	1.12
RMTg	alternative TSS	0	0	1.33
RMTg	gene expression	0	0	1.42
RMTg	isoform ratio	0	0	1.25
RMTg	intron excision ratio	0	0	1.37
RMTg	mRNA stability	0	0	1.51