Hub : Genes

Kif20a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000024428	0.03	0.02	3.3e-03	0.01	0.01	0.01	0.01	7.9e-03	1.5e-02	5.7e-02	1.7e-02
2	Brain	mRNA stability	ENSRNOG00000024428	0.04	0.03	1.7e-04	0.04	0.03	0.03	0.04	8.1e-05	7.3e-04	5.8e-04	1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	5.9	19.1	21.2	4.6	-4.1
BMI without tail	4.4	9.3	10.0	3.2	-2.9
Body weight	5.9	25.0	25.9	5.1	-4.9
Epididymis fat weight	5.0	11.7	12.0	3.5	-3.4
Glucose	7.6	11.6	12.4	3.5	-3.3
Heart weight	2.8	3.9	4.3	1.9	-2.1
Left kidney weight	0.1	0.4	0.7	0.3	-0.8
Right kidney weight	0.1	0.2	0.5	0.1	-0.7
Tail length	0.1	0.2	0.3	0.3	-0.6
Length with tail	0.7	2.7	2.8	1.6	-1.7
Length without tail	0.7	1.5	1.7	1.3	-1.1
Liver weight, left	0.0	0.0	0.1	0.1	-0.2
Liver weight, right	1.1	1.9	2.1	-1.3	1.5
Parametrial fat weight	1.0	1.9	3.3	1.8	-0.8
Retroperitoneal fat weight	4.0	13.1	16.3	4.0	-3.2
Intraocular pressure	4.5	6.4	7.1	2.4	-2.7
Extensor digitorum longus weight	2.1	8.3	8.5	2.9	-2.8
Soleus weight	2.1	6.2	7.2	2.7	-2.3
Tibialis anterior weight	0.7	2.5	2.9	1.5	-1.7
Tibia length	0.4	1.3	1.7	1.3	-0.9
Number of licking bursts	1.7	2.0	2.6	-1.6	1.2
Food consumed during 24 hour testing period	0.6	0.7	0.8	0.8	-0.9
Times rat made contact with spout	0.1	0.1	0.1	-0.4	-0.3
Mean time between licks in bursts	0.1	0.1	0.2	0.1	-0.4
Mean num. licks in bursts	1.7	2.1	2.2	1.4	-1.5
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.1	0.2
Water consumed over 24 hours	0.3	0.3	0.6	-0.8	0.3
Indifference point 0 sec	2.5	4.0	4.2	-2.0	1.9
Indifference point AUC	3.8	4.4	4.8	-2.0	2.2
Indifference point function ln k	8.9	12.6	13.1	3.5	-3.6
Indifference point function log k	8.9	12.6	13.1	3.5	-3.6
Delay discounting total patch changes 0 sec	2.4	4.0	4.5	-2.1	1.8
Delay discounting total patch changes 12 sec	11.8	15.6	16.9	-4.1	3.8
Delay discounting total patch changes 18 sec	5.9	7.9	7.9	-2.8	2.8
Delay discounting total patch changes 24 sec	3.9	4.9	5.5	-2.3	2.1
Delay discounting total patch changes 6 sec	4.9	7.5	8.0	-2.8	2.6
Delay discounting time to switch 0 sec	0.1	0.2	0.2	0.4	-0.4
Delay discounting water rate 0 sec	0.0	0.0	0.1	-0.3	0.1
Delay discounting water rate 12 sec	0.3	0.4	0.7	0.4	-0.9
Delay discounting water rate 18 sec	0.1	0.1	0.2	0.3	-0.4
Delay discounting water rate 24 sec	0.1	0.2	0.3	0.0	-0.6
Delay discounting water rate 6 sec	0.0	0.0	0.0	-0.1	-0.0
Locomotor activity	0.1	0.1	0.2	0.1	0.5
Locomotor testing distance	0.0	0.1	0.1	0.2	0.3
Locomotor testing rearing	0.6	1.0	1.1	-1.0	1.0
Light reinforcement 1	1.9	3.5	4.8	-2.2	1.5
Light reinforcement 2	3.0	3.9	4.0	-2.0	2.0
Reaction time number correct	0.9	1.3	1.7	1.0	-1.3
Reaction time mean minus median	0.4	0.5	0.9	-0.5	0.9
Reaction time mean minus median AUC	0.1	0.1	0.1	0.0	0.4
Reaction time num false alarms	1.2	1.7	2.4	1.5	-1.0
Reaction time num false alarms AUC	1.9	2.6	3.7	1.9	-1.3
Reaction time trials correct on left	0.9	1.3	1.7	1.0	-1.3
Reaction time trials on left	1.0	1.4	1.6	1.0	-1.3
Reaction time mean	0.6	0.9	1.7	1.3	-0.2
Reaction time mean AUC	0.4	0.6	1.1	1.1	0.1
Median of all reaction times	1.5	2.0	3.6	1.9	-0.7
Reaction time omissions	0.2	0.3	0.6	-0.1	0.7
Reaction time false alarm rate	0.7	1.0	1.7	1.3	-0.6
Reaction time premature initiation rate	4.1	5.5	7.4	-2.7	1.9
Reaction time premature initiations	2.1	2.9	4.2	-2.0	1.3
Std. dev. reaction times	0.1	0.2	0.4	0.6	0.1
Reaction time trials completed	1.0	1.4	1.6	1.0	-1.3
Reaction time trials AUC	1.0	1.4	1.8	1.0	-1.3
Social response proportion	1.0	1.1	1.9	1.4	-0.6
Social responses	0.5	0.6	1.2	-0.2	1.1
Social time	0.3	0.3	0.5	0.7	-0.4
Conditioned locomotion	0.1	0.1	0.1	-0.4	-0.2
Cocaine response after cond. corrected	0.3	0.4	0.6	0.4	-0.7
Cocaine response after cond. not corrected	0.0	0.1	0.1	-0.3	-0.0
Cocaine response before conditioning	5.0	6.0	6.1	-2.5	2.4
Saline control response	0.6	0.8	1.3	-1.2	0.5
Condit. Reinf. active minus inactive responses	3.5	4.4	4.4	-2.1	2.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	0.0
Condit. Reinf. active responses	8.7	12.1	12.6	-3.5	3.4
Condit. Reinf. inactive responses	9.5	11.8	12.5	-3.5	3.3
Condit. Reinf. lever presses	2.6	3.5	3.6	-1.9	1.9
Condit. Reinf. lever reinforcers received	7.8	11.0	11.1	-3.3	3.3
Pavlov. Cond. lever latency	1.0	1.4	1.5	1.2	-1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.2
Pavlov. Cond. change in total contacts	1.2	1.7	2.0	-1.1	1.4
Pavlov. Cond. index score	0.5	0.6	0.7	-0.7	0.8
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.6	0.8
Pavlov. Cond. lever contacts	1.3	1.8	2.0	-1.4	1.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.2	1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.7	0.9
Pavlov. Cond. response bias	2.0	2.8	3.0	-1.7	1.6
Conditioned reinforcement - actives	0.1	0.1	0.1	-0.0	-0.3
Conditioned reinforcement - inactives	0.2	0.3	0.5	-0.7	-0.1
Conditioned locomotion	0.2	0.2	0.2	-0.4	0.5
Intermittent access intake day 1-15 change	0.3	0.3	0.4	0.5	-0.6
Intermittent access intake escalation	0.1	0.0	0.1	0.1	-0.3
Intermittent access intake escalation 2	0.3	0.3	0.3	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	-0.3	-0.2
Intermitt. access escalation Index	1.5	1.3	1.3	1.1	-1.1
Intermittent access day 1 total infusions	0.3	0.3	0.5	-0.7	0.4
Intermittent access day 15 total infusions	0.3	0.3	0.5	-0.7	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.5	0.0
Intermittent access total infusions	0.0	0.1	0.1	-0.2	-0.3
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	0.1
Intermittent access day 15 total locomotion	2.0	2.1	2.8	1.2	-1.7
Intermittent access total locomotion	0.8	0.9	1.0	0.9	-1.0
Intermittent access standard deviation	0.2	0.2	0.3	0.5	-0.2
Cocaine induced anxiety	0.2	0.2	0.4	0.6	-0.1
Post-drug Anxiety	0.1	0.1	0.2	-0.2	0.5
Baseline Anxiety	0.3	0.4	0.5	-0.7	0.5
Lifetime Intake	0.1	0.1	0.1	-0.0	-0.4
Incentive Sensitization - Responses	0.2	0.2	0.4	0.2	-0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.3	-0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.0	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.1	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.6	0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.5	0.3	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	0.9	0.6	-1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.1	-0.4
Total sessions with >9 infusions	1.3	1.4	1.6	1.1	-1.3
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.6	0.4
Short access day 10 total inactive lever presses	0.3	0.4	0.7	-0.8	0.1
Short access day 1 total infusions	0.3	0.3	0.4	0.6	-0.6
Short access day 10 total infusions	0.1	0.1	0.1	-0.4	-0.0
Short access total infusions	0.0	0.0	0.0	-0.2	0.0
Short access day 1 locomotion	1.1	1.1	1.2	1.1	-1.1
Short access day 10 total locomotion	1.7	1.9	1.9	1.4	-1.3
Short access total locomotion	0.7	0.7	0.8	0.9	-0.8
Compulsive drug intake	1.1	1.1	1.2	1.0	-1.1
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.3	-0.7
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	0.2
Number of responses in last shaping day	2.4	2.5	2.8	-1.7	1.5
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	0.1
Locomotion velocity, session 1	0.4	0.4	0.7	0.8	-0.4
Locomotion distance, session 1	0.0	0.0	0.1	0.0	-0.3
Locomotion velocity, session 2	0.7	0.9	0.9	1.0	-0.9
Locomotion distance, session 2	0.5	0.8	1.0	-1.0	0.8
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	-0.1
Locomotion distance, session 3	0.1	0.2	0.3	-0.5	0.2
Stereotopy head waving bouts, day 3	2.4	2.9	3.9	-1.4	2.0
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.2	0.7
Locomotion velocity, session 7	0.2	0.2	0.3	0.3	-0.5
Locomotion distance, session 7	0.3	0.4	0.5	-0.7	0.5
Stereotopy head waving bouts, day 7	0.7	0.8	1.4	1.2	-0.4
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.7	-0.0
Locomotion velocity, session 8	0.3	0.3	0.6	0.8	-0.2
Locomotion distance, session 8	0.1	0.1	0.1	-0.3	0.2
Degree of sensitization distance	0.1	0.1	0.1	0.3	-0.2
Degree of sensitization stereotypy	0.4	0.4	0.7	0.8	-0.2
Condit. Reinf. active minus inactive responses	2.5	2.8	3.3	-1.5	1.8
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.4	-1.2	1.1
Condit. Reinf. active responses	2.8	3.4	3.5	-1.8	1.9
Condit. Reinf. inactive responses	1.9	2.2	2.3	-1.5	1.5
Incentive salience index mean	1.8	2.1	2.5	-1.3	1.6
Condit. Reinf. lever presses	1.0	1.4	1.5	-1.1	1.2
Time in familiar zone, hab. session 1	0.2	0.1	0.3	0.2	-0.5
Time in novel zone, hab. session 1	0.9	0.8	1.1	-0.8	1.0
Total zone transitions, hab. session 1	2.7	3.7	4.3	1.8	-2.1
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.2	-0.4
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.3	-0.3
Time in familiar zone, hab. session 2	6.1	6.3	6.6	-2.5	2.6
Time in novel zone, hab. session 2	4.7	4.7	5.1	2.3	-2.1
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.3	-0.6
Total locomotion distance, hab. session 2	0.4	0.6	0.7	-0.8	0.7
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.5	0.2
Novel to familiar place preference ratio	2.8	2.9	3.2	1.8	-1.6
Novelty place preference	3.4	3.5	3.9	2.0	-1.7
Time in novel zone, NPP test	2.8	3.0	3.3	1.8	-1.6
Total zone transitions, NPP test	0.1	0.1	0.2	-0.1	-0.4
Total locomotion distance, NPP test	0.4	0.6	0.9	-0.9	0.5
Locomotion velocity, NPP test	0.5	0.8	1.2	-1.1	0.6
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.1	0.3
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.1	0.4
Pavlov. Cond. response bias	0.2	0.2	0.2	-0.4	0.5
Bone: apparent density	0.4	0.6	0.9	-0.9	0.5
Bone surface	1.0	1.8	2.3	-1.5	1.1
Bone volume	0.8	1.3	1.6	-1.3	1.0
Bone: connectivity density	1.9	3.0	3.3	-1.8	1.6
Bone: cortical apparent density	0.9	1.1	1.2	-1.0	1.1
Bone: cortical area	3.3	5.0	6.1	-2.5	2.0
Bone: cortical porosity	1.0	1.1	1.4	1.2	-0.8
Bone: cortical porosity	0.7	0.7	1.0	1.0	-0.7
Bone: cortical thickness	2.6	4.2	5.1	-2.3	1.8
Bone: cortical thickness	0.6	0.7	1.0	-1.0	0.6
Bone: cortical tissue density	0.7	0.8	1.0	-0.8	1.0
Bone: elastic displacement	1.5	1.7	1.7	1.3	-1.3
Bone: elastic work	2.1	2.7	3.0	1.5	-1.7
Bone: endosteal estimation	0.7	1.5	1.6	-1.3	1.2
Bone: endosteal perimeter	0.1	0.2	0.2	-0.4	0.5
Bone: final force	1.2	2.0	2.4	-1.5	1.2
Bone: final moment	0.7	1.1	1.5	-1.2	0.9
Bone: marrow area	0.7	1.5	1.6	-1.3	1.1
Bone: maximum diameter	2.8	5.2	6.3	-2.5	2.0
Bone: maximum force	0.3	0.6	0.9	-1.0	0.5
Bone: maximum moment	0.1	0.2	0.3	-0.6	0.2
Bone: minimum diameter	1.0	1.9	2.3	-1.5	1.2
Bone: periosteal estimation	1.7	3.5	4.3	-2.1	1.7
Bone: periosteal perimeter	0.8	1.4	1.6	-1.3	1.1
Bone: post-yield work	0.1	0.2	0.3	-0.5	0.3
Bone: stiffness	0.9	1.4	1.7	-1.3	1.0
Bone: tissue strength	0.0	0.0	0.0	0.2	0.0
Bone: trabecular number	0.3	0.4	0.7	-0.8	0.4
Bone: trabecular spacing	0.1	0.2	0.3	-0.1	0.6
Bone: trabecular thickness	0.5	0.6	0.6	-0.8	0.8
Bone: trabecular tissue density	0.2	0.2	0.3	0.4	-0.5
Breakpoint value in progressive ratio session	0.6	0.6	1.2	0.2	-1.1
Distance traveled before self-admin	0.1	0.1	0.1	0.3	-0.0
Distance traveled after self-admin	0.8	0.9	1.0	-1.0	0.9
Delta time in closed arm before/after self-admin	4.0	3.9	5.2	2.3	-1.6
Delta time in open arm before/after self-admin	0.7	0.7	0.9	-0.9	0.7
Diff in mean of infusions in LGA sessions	0.9	1.1	1.4	0.9	-1.2
Extinction: sum of active levers before priming	0.3	0.3	0.3	0.6	-0.6
Active lever presses in extinction session 6	2.1	2.0	3.1	-1.8	0.9
Delta distance traveled before/after self-admin	3.5	3.7	4.7	-2.2	1.7
Delta ambulatory time before/after self-admin	3.3	3.6	4.6	-2.1	1.6
Time in closed arm before self-admin	0.5	0.6	1.0	0.4	-1.0
Time in closed arm after self-admin	1.3	1.3	1.3	1.2	-1.1
Time in open arm before self-admin	0.1	0.1	0.2	-0.1	0.5
Time in open arm after self-admin	0.4	0.4	0.5	-0.7	0.6
Sum of active levers in priming session hrs 5-6	2.9	2.9	3.3	-1.6	1.8
Time to tail flick, vehicle, before self-admin	3.8	3.8	5.0	-1.6	2.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	-0.3	0.7
Time to tail flick, test, before self-admin	0.8	0.8	1.4	0.4	-1.2
Time to tail flick, test, after self-admin	0.5	0.5	0.7	-0.5	0.8
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	0.6	-0.8
Delta time to tail flick, test, before/after SA	0.7	0.7	1.3	0.1	1.1
Ambulatory time before self-admin	0.1	0.1	0.1	0.3	-0.2
Ambulatory time after self-admin	0.7	0.8	0.8	-0.9	0.9
Total heroin consumption	0.8	0.9	1.3	0.7	-1.1
Area under the delay curve	4.7	5.0	5.4	-2.1	2.3
Delay disc. indifference point, 0s delay	1.8	1.9	1.9	-1.4	1.4
Delay disc. indifference point, 16s delay	5.4	5.5	5.8	-2.3	2.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	-0.6	1.0
Delay disc. indifference point, 24s delay	0.9	0.9	1.1	-0.9	1.0
Delay disc. indifference point, 4s delay	0.7	0.7	0.8	-0.8	0.9
Delay disc. indifference point, 8s delay	6.4	6.6	6.9	-2.5	2.6
Delay discount exponential model param	4.8	5.1	5.6	2.2	-2.4
Delay discount hyperbolic model param	4.4	4.7	5.0	2.1	-2.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.3	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	0.5	-0.7
Bouts of movement, locomotor time 1	2.1	2.4	3.6	-1.9	1.1
Total resting periods, locomotor time 1	1.8	2.0	3.0	-1.7	1.0
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.3	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.3	-0.1
Vertical activity count, locomotor time 1	0.9	0.9	1.1	1.0	-0.9
Time >=10cm from walls, locomotor time 2	6.7	7.1	7.3	2.7	-2.6
Bouts of movement, locomotor time 2	0.3	0.3	0.4	-0.6	0.5
Total resting periods, locomotor time 2	0.1	0.1	0.1	-0.4	0.2
Rest time, locomotor task time 2	1.1	1.2	1.5	1.2	-1.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.2	-0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.2	0.0
Weight adjusted by age	1.7	1.9	2.6	1.6	-1.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	-0.8	0.3
Locomotion in novel chamber	0.0	0.0	0.0	0.1	0.2
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.0	-0.0
Progressive ratio	0.0	0.0	0.0	0.0	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	-0.2
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.1	0.4
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	0.3
Latency to leave start box in cocaine runway	2.4	2.6	2.7	-1.6	1.7
Latency to leave start box in cocaine runway, F	1.9	2.1	2.4	-1.6	1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.4
Cd content in liver	0.0	0.0	0.0	-0.1	0.1
Co content in liver	0.1	0.2	0.3	0.5	-0.3
Cu content in liver	4.5	5.4	5.9	-2.2	2.4
Fe content in liver	1.8	2.2	2.7	-1.3	1.6
K content in liver	0.2	0.2	0.3	-0.3	0.5
Mg content in liver	1.5	1.6	1.7	-1.3	1.2
Mn content in liver	0.2	0.3	0.4	0.4	-0.6
Na content in liver	0.0	0.0	0.0	0.1	0.1
Rb content in liver	3.0	3.7	3.7	-1.9	1.9
Se content in liver	0.4	0.5	0.6	-0.6	0.8
Sr content in liver	0.6	0.5	0.7	-0.6	0.9
Zn content in liver	2.2	2.5	2.6	-1.6	1.5