| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | mRNA stability | ENSRNOG00000054775 | 0.0600 | 0.0470 | 4.5e-07 | 0.047 | 0.041 | 0.045 | 0.042 | 5.3e-06 | 2.3e-05 | 9.1e-06 | 1.7e-05 |
| 2 | BLA | mRNA stability | ENSRNOG00000054775 | 0.7200 | 0.0820 | 0.0e+00 | 0.668 | 0.707 | 0.706 | 0.715 | 4.5e-47 | 3.0e-52 | 4.5e-52 | 2.1e-53 |
| 3 | Brain | gene expression | ENSRNOG00000054775 | 0.0330 | 0.0310 | 4.4e-03 | 0.010 | 0.008 | 0.007 | 0.003 | 3.9e-02 | 5.3e-02 | 7.0e-02 | 1.4e-01 |
| 4 | Brain | mRNA stability | ENSRNOG00000054775 | 0.8147 | 0.0892 | 0.0e+00 | 0.715 | 0.700 | 0.713 | 0.713 | 3.4e-94 | 3.1e-90 | 1.5e-93 | 1.8e-93 |
| 5 | Eye | mRNA stability | ENSRNOG00000054775 | 0.5690 | 0.2610 | 2.2e-06 | 0.328 | 0.236 | 0.283 | 0.286 | 5.4e-06 | 1.5e-04 | 2.9e-05 | 2.7e-05 |
| 6 | IL | mRNA stability | ENSRNOG00000054775 | 0.5380 | 0.1630 | 1.7e-09 | 0.351 | 0.314 | 0.328 | 0.344 | 2.8e-09 | 2.6e-08 | 1.2e-08 | 4.3e-09 |
| 7 | LHb | mRNA stability | ENSRNOG00000054775 | 0.3640 | 0.2030 | 1.4e-04 | 0.176 | 0.159 | 0.042 | 0.166 | 5.7e-05 | 1.3e-04 | 3.7e-02 | 9.3e-05 |
| 8 | Liver | mRNA stability | ENSRNOG00000054775 | 0.0638 | 0.0476 | 3.3e-06 | 0.041 | 0.035 | 0.029 | 0.034 | 2.0e-05 | 8.9e-05 | 3.0e-04 | 1.1e-04 |
| 9 | NAcc | mRNA stability | ENSRNOG00000054775 | 0.9252 | 0.0193 | 0.0e+00 | 0.359 | 0.265 | 0.340 | 0.382 | 7.3e-28 | 8.0e-20 | 4.5e-26 | 6.1e-30 |
| 10 | PL | mRNA stability | ENSRNOG00000054775 | 0.4149 | 0.1303 | 0.0e+00 | 0.480 | 0.515 | 0.513 | 0.516 | 6.7e-41 | 4.8e-45 | 9.6e-45 | 3.4e-45 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: stiffness | 16.5 | 26.2 | 27.9 | -5.1 | -5.1 | -5.1 | -5.1 | -5.2 | -5.0 | -5.1 | -5.1 | -5.1 | -5.3 |
| Bone: maximum force | 13.4 | 23.3 | 25.8 | -4.7 | -4.8 | -4.8 | -4.8 | -4.8 | -4.8 | -4.8 | -4.8 | -4.9 | -5.1 |
| Bone: maximum moment | 13.4 | 23.3 | 26.7 | -4.6 | -4.7 | -4.8 | -4.8 | -4.8 | -4.8 | -4.8 | -4.8 | -4.9 | -5.2 |
| Bone: periosteal estimation | 12.2 | 25.0 | 26.8 | -5.0 | -4.9 | -5.0 | -5.2 | -5.0 | -5.0 | -5.0 | -4.9 | -4.9 | -5.0 |
| Bone surface | 12.0 | 21.2 | 22.5 | -4.5 | -4.5 | -4.6 | -4.7 | -4.6 | -4.6 | -4.6 | -4.5 | -4.7 | -4.7 |
| Bone: periosteal perimeter | 10.8 | 17.8 | 19.4 | -4.1 | -4.2 | -4.3 | -4.4 | -4.2 | -4.2 | -4.3 | -4.2 | -4.2 | -4.2 |
| Bone: cortical area | 10.5 | 15.9 | 17.2 | -3.9 | -4.0 | -4.0 | -4.1 | -4.0 | -4.0 | -4.0 | -4.0 | -3.9 | -3.9 |
| Reaction time omissions | 10.3 | 13.9 | 14.5 | 3.8 | 3.8 | 3.8 | 3.6 | 3.7 | 3.7 | 3.8 | 3.8 | 3.6 | 3.8 |
| Bone: apparent density | 10.3 | 17.0 | 18.2 | -4.1 | -4.0 | -4.1 | -4.2 | -4.1 | -4.1 | -4.1 | -4.0 | -4.3 | -4.3 |
| Bone: final moment | 10.2 | 16.8 | 18.0 | -3.9 | -4.0 | -4.1 | -4.1 | -4.1 | -4.1 | -4.1 | -4.1 | -4.2 | -4.2 |
| Bone: final force | 10.1 | 16.5 | 17.1 | -3.9 | -4.0 | -4.1 | -4.0 | -4.1 | -4.1 | -4.1 | -4.0 | -4.1 | -4.1 |
| Bone: minimum diameter | 9.1 | 16.8 | 18.5 | -4.0 | -4.1 | -4.2 | -4.3 | -4.0 | -4.1 | -4.2 | -4.0 | -4.0 | -4.2 |
| Bone volume | 8.9 | 15.1 | 16.5 | -3.7 | -3.8 | -3.9 | -4.1 | -3.9 | -3.9 | -3.9 | -3.8 | -4.0 | -4.0 |
| Tibia length | 8.0 | 22.6 | 24.6 | -5.0 | -4.8 | -4.8 | -4.5 | -4.9 | -4.7 | -4.7 | -5.0 | -4.5 | -4.6 |
| Length without tail | 7.8 | 17.0 | 18.3 | -3.9 | -4.1 | -4.3 | -4.0 | -4.0 | -4.1 | -4.3 | -4.2 | -4.2 | -4.1 |
| Reaction time mean minus median | 7.8 | 10.1 | 11.8 | 3.0 | 3.1 | 3.2 | 3.2 | 3.1 | 3.4 | 3.2 | 3.1 | 3.0 | 3.4 |
| Intraocular pressure | 7.5 | 10.6 | 11.3 | 3.1 | 3.3 | 3.3 | 3.3 | 3.2 | 3.3 | 3.3 | 3.2 | 3.4 | 3.3 |
| Bone: connectivity density | 7.4 | 11.5 | 12.6 | -3.4 | -3.3 | -3.4 | -3.5 | -3.4 | -3.4 | -3.4 | -3.3 | -3.5 | -3.5 |
| Bone: post-yield work | 7.4 | 10.1 | 11.7 | -3.3 | -3.2 | -3.1 | -3.2 | -3.2 | -3.1 | -3.1 | -3.2 | -3.0 | -3.4 |
| Bone: endosteal estimation | 7.1 | 15.4 | 17.1 | -3.9 | -3.8 | -3.9 | -4.0 | -3.9 | -3.9 | -3.9 | -3.9 | -3.8 | -4.1 |
| Social responses | 7.0 | 9.1 | 11.0 | 2.8 | 2.9 | 3.0 | 3.1 | 2.8 | 3.1 | 3.0 | 2.9 | 3.3 | 3.3 |
| Bone: endosteal perimeter | 7.0 | 14.5 | 16.0 | -3.7 | -3.8 | -3.8 | -4.0 | -3.8 | -3.8 | -3.8 | -3.8 | -3.7 | -3.8 |
| Bone: marrow area | 7.0 | 15.0 | 16.7 | -3.8 | -3.8 | -3.9 | -4.0 | -3.8 | -3.8 | -3.9 | -3.8 | -3.8 | -4.1 |
| Body weight | 6.8 | 28.6 | 30.4 | -5.5 | -5.4 | -5.4 | -5.0 | -5.5 | -5.4 | -5.4 | -5.5 | -5.3 | -5.1 |
| Bone: trabecular number | 6.0 | 9.3 | 10.6 | -3.1 | -2.9 | -2.9 | -3.2 | -3.0 | -2.9 | -2.9 | -3.0 | -3.2 | -3.3 |
| Reaction time mean minus median AUC | 5.9 | 7.5 | 8.9 | 2.6 | 2.7 | 2.8 | 2.8 | 2.6 | 3.0 | 2.8 | 2.7 | 2.6 | 2.8 |
| Std. dev. reaction times | 5.8 | 7.9 | 9.0 | 2.6 | 2.8 | 2.8 | 2.9 | 2.7 | 3.0 | 2.8 | 2.8 | 2.7 | 3.0 |
| Locomotion distance, session 3 | 5.5 | 6.0 | 7.0 | 2.6 | 2.4 | 2.3 | 2.4 | 2.6 | 2.4 | 2.3 | 2.6 | 2.3 | 2.3 |
| Reaction time premature initiation rate | 5.4 | 7.3 | 9.2 | 2.5 | 2.6 | 2.6 | 2.9 | 2.7 | 2.7 | 2.6 | 2.6 | 2.9 | 3.0 |
| Bone: elastic displacement | 5.2 | 5.9 | 6.6 | 2.4 | 2.5 | 2.4 | 2.4 | 2.6 | 2.4 | 2.4 | 2.5 | 2.4 | 2.3 |
| Post-drug Anxiety | 5.0 | 5.5 | 6.1 | -2.2 | -2.5 | -2.4 | -2.3 | -2.3 | -2.3 | -2.4 | -2.5 | -2.2 | -2.4 |
| BMI with tail | 4.9 | 16.0 | 17.5 | -4.2 | -4.2 | -3.9 | -3.8 | -4.1 | -4.0 | -3.9 | -4.2 | -4.0 | -3.8 |
| Pavlov. Cond. intertrial magazine entries | 4.9 | 6.3 | 6.9 | 2.6 | 2.6 | 2.5 | 2.3 | 2.6 | 2.4 | 2.5 | 2.6 | 2.5 | 2.6 |
| Extensor digitorum longus weight | 4.6 | 18.6 | 20.6 | -4.3 | -4.4 | -4.5 | -3.8 | -4.3 | -4.4 | -4.5 | -4.4 | -4.3 | -4.0 |
| Bone: maximum diameter | 4.5 | 8.2 | 9.1 | -3.0 | -2.8 | -2.9 | -3.0 | -2.9 | -2.9 | -2.9 | -2.8 | -2.7 | -2.6 |
| Bone: cortical thickness | 4.4 | 7.3 | 7.8 | -2.6 | -2.7 | -2.8 | -2.7 | -2.8 | -2.8 | -2.8 | -2.7 | -2.7 | -2.5 |
| Delta time in open arm before/after self-admin | 4.3 | 4.1 | 4.5 | 2.1 | 2.1 | 1.9 | 2.1 | 2.0 | 2.0 | 1.9 | 2.0 | 2.0 | 2.1 |
| Delay discounting total patch changes 18 sec | 4.2 | 5.5 | 7.2 | 2.0 | 2.3 | 2.4 | 2.1 | 2.3 | 2.5 | 2.4 | 2.3 | 2.7 | 2.4 |
| Progressive ratio test 1 active lever presses | 4.2 | 4.4 | 5.1 | 2.2 | 2.1 | 2.0 | 2.1 | 2.2 | 1.8 | 2.0 | 2.2 | 2.1 | 2.3 |
| Ambulatory time before self-admin | 4.0 | 4.2 | 4.7 | 2.0 | 2.0 | 1.9 | 2.2 | 2.1 | 2.1 | 2.0 | 2.1 | 2.1 | 2.0 |
| Cocaine response before conditioning | 3.9 | 4.8 | 5.7 | 2.0 | 2.2 | 2.2 | 2.0 | 2.1 | 2.3 | 2.2 | 2.2 | 2.4 | 2.2 |
| Locomotion velocity, session 3 | 3.9 | 4.6 | 5.0 | 2.2 | 2.2 | 2.1 | 2.2 | 2.2 | 2.0 | 2.1 | 2.2 | 2.0 | 2.1 |
| Progressive ratio test 1 breakpoint | 3.8 | 3.9 | 4.7 | 2.0 | 2.0 | 1.9 | 2.0 | 2.0 | 1.7 | 1.9 | 2.1 | 2.0 | 2.2 |
| Delay discounting water rate 6 sec | 3.7 | 5.4 | 6.1 | -2.1 | -2.2 | -2.4 | -2.5 | -2.2 | -2.4 | -2.4 | -2.2 | -2.4 | -2.4 |
| Progressive ratio test 1 inactive lever presses | 3.7 | 3.9 | 4.5 | 2.0 | 2.0 | 1.9 | 2.0 | 1.9 | 1.9 | 1.9 | 1.9 | 2.1 | 2.1 |
| Intermitt. access day 1 inactive lever presses | 3.5 | 3.8 | 4.6 | 1.9 | 2.0 | 2.0 | 1.9 | 1.8 | 2.0 | 2.0 | 2.0 | 2.1 | 1.7 |
| Indifference point function ln k | 3.4 | 4.9 | 5.3 | -2.1 | -2.1 | -2.3 | -2.2 | -2.2 | -2.2 | -2.3 | -2.1 | -2.2 | -2.3 |
| Indifference point function log k | 3.4 | 4.9 | 5.3 | -2.1 | -2.1 | -2.3 | -2.2 | -2.2 | -2.2 | -2.3 | -2.1 | -2.2 | -2.3 |
| Delay discounting water rate 12 sec | 3.4 | 5.2 | 5.8 | -2.2 | -2.2 | -2.4 | -2.4 | -2.2 | -2.3 | -2.3 | -2.2 | -2.2 | -2.4 |
| Intermittent access total locomotion | 3.3 | 3.8 | 4.8 | 1.9 | 1.8 | 1.9 | 1.9 | 2.0 | 1.8 | 1.9 | 1.9 | 2.2 | 2.1 |
| Locomotion distance, session 1 | 3.3 | 4.2 | 5.1 | 2.3 | 2.1 | 2.0 | 2.2 | 2.1 | 2.0 | 2.0 | 2.2 | 1.8 | 1.9 |
| Delay discounting water rate 0 sec | 3.2 | 5.1 | 6.0 | -2.3 | -2.2 | -2.2 | -2.4 | -2.3 | -2.3 | -2.3 | -2.2 | -2.1 | -2.2 |
| Delay discounting water rate 24 sec | 3.1 | 4.2 | 4.9 | -2.0 | -2.0 | -2.1 | -2.2 | -2.0 | -2.1 | -2.2 | -2.0 | -1.9 | -2.1 |
| Delay disc. indifference point, 8s delay | 3.1 | 3.2 | 3.8 | -1.8 | -1.8 | -1.8 | -1.6 | -1.9 | -1.8 | -1.8 | -1.9 | -1.9 | -1.7 |
| Right kidney weight | 2.9 | 8.2 | 9.6 | -3.0 | -2.7 | -2.9 | -2.9 | -3.1 | -2.8 | -2.9 | -2.8 | -2.8 | -2.7 |
| Light reinforcement 1 | 2.9 | 5.3 | 6.1 | 2.1 | 2.4 | 2.2 | 2.2 | 2.5 | 2.1 | 2.3 | 2.4 | 2.4 | 2.3 |
| Total resting periods, locomotor time 2 | 2.9 | 3.1 | 3.7 | -1.9 | -1.8 | -1.7 | -1.7 | -1.9 | -1.6 | -1.7 | -1.8 | -1.6 | -1.8 |
| Locomotor testing distance | 2.8 | 4.7 | 5.0 | 2.2 | 2.2 | 2.1 | 2.1 | 2.2 | 2.1 | 2.1 | 2.2 | 2.1 | 2.2 |
| Progressive ratio test 2 breakpoint | 2.8 | 3.1 | 4.0 | 1.7 | 1.7 | 1.7 | 2.0 | 1.8 | 1.7 | 1.7 | 1.8 | 1.7 | 1.9 |
| Reaction time premature initiations | 2.7 | 3.8 | 4.5 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 2.1 | 2.1 |
| Intermittent access terminal intake (last 3 days) | 2.7 | 2.9 | 3.5 | 1.9 | 1.6 | 1.7 | 1.7 | 1.9 | 1.6 | 1.7 | 1.7 | 1.6 | 1.8 |
| Reaction time num false alarms AUC | 2.6 | 3.6 | 3.9 | 1.9 | 2.0 | 1.9 | 1.8 | 1.8 | 2.0 | 2.0 | 2.0 | 1.9 | 1.9 |
| Reaction time false alarm rate | 2.6 | 3.6 | 4.0 | 1.8 | 1.9 | 1.9 | 2.0 | 1.8 | 2.0 | 1.9 | 1.9 | 1.9 | 2.0 |
| Progressive ratio test 2 inactive lever presses | 2.6 | 3.0 | 3.6 | 1.7 | 1.6 | 1.7 | 1.9 | 1.7 | 1.7 | 1.7 | 1.7 | 1.8 | 1.8 |
| Locomotion distance, session 2 | 2.6 | 3.7 | 4.6 | 2.1 | 1.9 | 1.8 | 2.0 | 2.0 | 1.8 | 1.8 | 2.0 | 1.8 | 1.8 |
| Condit. Reinf. inactive responses | 2.6 | 3.0 | 3.4 | 1.7 | 1.7 | 1.7 | 1.8 | 1.6 | 1.8 | 1.7 | 1.7 | 1.8 | 1.8 |
| Bouts of movement, locomotor time 2 | 2.6 | 2.8 | 3.4 | -1.8 | -1.7 | -1.7 | -1.6 | -1.8 | -1.5 | -1.7 | -1.7 | -1.6 | -1.7 |
| Delay discounting time to switch 0 sec | 2.4 | 3.6 | 4.8 | 1.9 | 1.9 | 1.8 | 2.2 | 1.9 | 1.9 | 1.9 | 1.9 | 1.8 | 1.8 |
| Weight adjusted by age | 2.4 | 2.7 | 3.2 | -1.6 | -1.7 | -1.7 | -1.6 | -1.6 | -1.8 | -1.7 | -1.7 | -1.6 | -1.5 |
| Pavlov. Cond. magazine entry number | 2.3 | 2.8 | 3.0 | 1.7 | 1.7 | 1.7 | 1.7 | 1.7 | 1.6 | 1.7 | 1.7 | 1.6 | 1.7 |
| Intermittent access total infusions | 2.3 | 2.6 | 3.1 | 1.8 | 1.4 | 1.5 | 1.7 | 1.7 | 1.5 | 1.5 | 1.6 | 1.6 | 1.8 |
| Delay discounting total patch changes 6 sec | 2.2 | 3.4 | 3.9 | 1.7 | 1.8 | 1.8 | 1.7 | 1.9 | 1.9 | 1.8 | 1.8 | 1.9 | 2.0 |
| Locomotor testing rearing | 2.2 | 3.5 | 4.0 | 1.7 | 1.8 | 1.8 | 2.0 | 1.8 | 1.9 | 1.7 | 1.9 | 2.0 | 2.0 |
| Intermittent access day 15 total infusions | 2.2 | 2.5 | 3.1 | 1.7 | 1.4 | 1.5 | 1.7 | 1.7 | 1.4 | 1.5 | 1.6 | 1.5 | 1.8 |
| Progressive ratio test 2 active lever presses | 2.2 | 2.3 | 3.1 | 1.4 | 1.4 | 1.4 | 1.8 | 1.5 | 1.4 | 1.4 | 1.6 | 1.5 | 1.6 |
| Latency to leave start box in cocaine runway, M | 2.2 | 2.1 | 2.7 | -1.6 | -1.4 | -1.4 | -1.5 | -1.6 | -1.3 | -1.4 | -1.4 | -1.4 | -1.4 |
| Liver weight, left | 2.1 | 3.3 | 3.6 | -1.9 | -1.8 | -1.8 | -1.8 | -1.7 | -1.9 | -1.9 | -1.8 | -1.9 | -1.8 |
| Indifference point 0 sec | 2.1 | 3.4 | 3.8 | 1.8 | 1.9 | 1.8 | 1.7 | 1.9 | 1.9 | 1.8 | 1.9 | 1.9 | 2.0 |
| Delay discounting total patch changes 0 sec | 2.1 | 3.3 | 3.7 | 1.7 | 1.9 | 1.8 | 1.7 | 1.9 | 1.9 | 1.8 | 1.9 | 1.9 | 1.9 |
| Bone: trabecular spacing | 2.1 | 2.8 | 3.3 | 1.8 | 1.5 | 1.6 | 1.7 | 1.7 | 1.6 | 1.6 | 1.6 | 1.8 | 1.8 |
| Length with tail | 2.0 | 7.2 | 7.9 | -2.7 | -2.5 | -2.8 | -2.6 | -2.8 | -2.7 | -2.8 | -2.7 | -2.6 | -2.7 |
| Lifetime Intake | 2.0 | 2.2 | 3.0 | 1.6 | 1.3 | 1.3 | 1.6 | 1.6 | 1.3 | 1.3 | 1.5 | 1.5 | 1.7 |
| Bone: cortical porosity | 2.0 | 2.1 | 2.8 | 1.7 | 1.4 | 1.5 | 1.1 | 1.6 | 1.5 | 1.5 | 1.6 | 1.5 | 1.2 |
| Parametrial fat weight | 1.9 | 3.7 | 4.2 | 1.9 | 1.9 | 1.9 | 2.0 | 1.9 | 2.0 | 2.0 | 1.8 | 1.8 | 2.1 |
| Pavlov. Cond. change in total contacts | 1.9 | 2.6 | 2.8 | -1.6 | -1.7 | -1.7 | -1.5 | -1.6 | -1.6 | -1.7 | -1.6 | -1.6 | -1.4 |
| Total locomotion distance, NPP test | 1.9 | 2.7 | 3.4 | 1.9 | 1.6 | 1.5 | 1.8 | 1.8 | 1.5 | 1.5 | 1.7 | 1.5 | 1.5 |
| Total heroin consumption | 1.9 | 2.2 | 2.5 | -1.5 | -1.6 | -1.5 | -1.5 | -1.4 | -1.6 | -1.4 | -1.5 | -1.5 | -1.5 |
| Latency to leave start box in cocaine runway, F | 1.9 | 2.1 | 2.7 | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.6 | 1.4 | 1.5 | 1.6 | 1.4 |
| Food consumed during 24 hour testing period | 1.8 | 2.2 | 2.9 | -1.4 | -1.4 | -1.5 | -1.7 | -1.4 | -1.5 | -1.5 | -1.4 | -1.6 | -1.5 |
| Delay discounting total patch changes 24 sec | 1.8 | 2.3 | 3.0 | 1.4 | 1.6 | 1.4 | 1.4 | 1.5 | 1.5 | 1.4 | 1.6 | 1.7 | 1.6 |
| Reaction time num false alarms | 1.8 | 2.5 | 2.8 | 1.6 | 1.6 | 1.6 | 1.4 | 1.5 | 1.7 | 1.6 | 1.6 | 1.7 | 1.5 |
| Novel to familiar place preference ratio | 1.7 | 1.8 | 2.2 | -1.5 | -1.4 | -1.4 | -1.3 | -1.2 | -1.4 | -1.4 | -1.3 | -1.2 | -1.4 |
| Liver weight, right | 1.6 | 2.7 | 2.9 | -1.5 | -1.6 | -1.6 | -1.6 | -1.6 | -1.7 | -1.7 | -1.7 | -1.7 | -1.6 |
| Delay discounting total patch changes 12 sec | 1.6 | 2.1 | 2.8 | 1.3 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.6 | 1.7 |
| Conditioned reinforcement - inactives | 1.6 | 1.8 | 2.6 | 1.4 | 1.4 | 1.3 | 1.4 | 1.3 | 1.3 | 1.3 | 1.3 | 1.3 | 1.6 |
| Locomotion distance, session 7 | 1.6 | 2.0 | 2.5 | 1.5 | 1.4 | 1.3 | 1.6 | 1.5 | 1.3 | 1.3 | 1.5 | 1.3 | 1.4 |
| Ambulatory time after self-admin | 1.6 | 1.8 | 2.2 | 1.2 | 1.3 | 1.2 | 1.5 | 1.4 | 1.4 | 1.3 | 1.3 | 1.4 | 1.4 |
| Delay disc. indifference point, 24s delay | 1.6 | 1.6 | 1.8 | -1.3 | -1.3 | -1.3 | -1.2 | -1.3 | -1.3 | -1.3 | -1.4 | -1.2 | -1.1 |
| Fecal boli incidents, locomotor time 1 | 1.6 | 1.8 | 2.2 | 1.5 | 1.3 | 1.3 | 1.4 | 1.4 | 1.3 | 1.3 | 1.4 | 0.8 | 1.4 |
| Diff in mean of infusions in LGA sessions | 1.5 | 1.7 | 2.4 | -1.3 | -1.2 | -1.2 | -1.4 | -1.2 | -1.3 | -1.2 | -1.2 | -1.5 | -1.4 |
| Time in closed arm before self-admin | 1.5 | 1.7 | 2.1 | -1.5 | -1.3 | -1.4 | -1.3 | -1.2 | -1.2 | -1.4 | -1.3 | -1.0 | -1.3 |
| Vertical activity count, locomotor time 1 | 1.5 | 1.6 | 1.9 | -1.1 | -1.3 | -1.3 | -1.2 | -1.2 | -1.2 | -1.3 | -1.3 | -1.4 | -1.2 |
| Run reversals in cocaine runway, males | 1.5 | 1.5 | 1.7 | 1.2 | 1.2 | 1.2 | 1.1 | 1.1 | 1.1 | 1.2 | 1.2 | 1.3 | 1.3 |
| Tibialis anterior weight | 1.4 | 4.8 | 5.5 | -2.3 | -2.3 | -2.4 | -1.7 | -2.2 | -2.3 | -2.4 | -2.3 | -2.1 | -1.8 |
| Conditioned reinforcement - actives | 1.4 | 1.4 | 1.8 | 1.1 | 1.2 | 1.2 | 1.2 | 1.1 | 1.1 | 1.2 | 1.2 | 1.2 | 1.4 |
| Intermitt. access day 15 inactive lever presses | 1.4 | 1.5 | 1.8 | 1.2 | 1.2 | 1.2 | 1.4 | 1.3 | 1.2 | 1.2 | 1.2 | 1.3 | 1.2 |
| Intermittent access day 15 total locomotion | 1.4 | 1.5 | 2.0 | 1.2 | 1.1 | 1.2 | 1.2 | 1.3 | 1.2 | 1.2 | 1.2 | 1.4 | 1.4 |
| Bone: cortical porosity | 1.4 | 1.5 | 2.0 | 1.4 | 1.2 | 1.3 | 0.9 | 1.4 | 1.3 | 1.3 | 1.3 | 1.3 | 1.0 |
| Reaction time trials AUC | 1.3 | 1.8 | 3.0 | -1.1 | -1.2 | -1.3 | -1.7 | -1.3 | -1.4 | -1.3 | -1.2 | -1.3 | -1.6 |
| Locomotion velocity, session 1 | 1.3 | 1.4 | 1.8 | 1.4 | 1.1 | 1.1 | 1.1 | 1.2 | 1.1 | 1.1 | 1.1 | 1.2 | 1.1 |
| Stereotopy head waving duration, day 7 | 1.3 | 1.6 | 2.6 | -1.4 | -1.2 | -1.2 | -1.6 | -1.3 | -1.3 | -1.2 | -1.3 | -1.0 | -1.2 |
| Locomotion distance, session 8 | 1.3 | 1.9 | 2.6 | 1.4 | 1.3 | 1.3 | 1.6 | 1.5 | 1.3 | 1.3 | 1.3 | 1.3 | 1.3 |
| Delay disc. indifference point, 0s delay | 1.3 | 1.4 | 1.8 | -1.2 | -1.1 | -1.1 | -1.3 | -1.2 | -1.1 | -1.1 | -1.2 | -1.1 | -1.2 |
| Delay disc. indifference point, 2s delay | 1.3 | 1.4 | 1.7 | -1.1 | -1.2 | -1.2 | -1.1 | -1.2 | -1.2 | -1.2 | -1.2 | -1.2 | -1.3 |
| Zn content in liver | 1.3 | 1.4 | 2.1 | 1.3 | 1.1 | 1.0 | 1.2 | 1.2 | 1.1 | 1.1 | 1.1 | 1.3 | 1.4 |
| Intermittent access intake escalation 2 | 1.2 | 1.2 | 1.7 | 1.1 | 1.0 | 1.0 | 1.3 | 1.2 | 1.0 | 1.0 | 1.1 | 0.9 | 1.2 |
| Intermittent access day 1 total infusions | 1.2 | 1.3 | 1.7 | 1.3 | 1.1 | 1.1 | 1.0 | 1.2 | 1.1 | 1.1 | 1.1 | 1.1 | 1.2 |
| Stereotopy head waving bouts, day 3 | 1.2 | 1.4 | 1.8 | -1.1 | -1.1 | -1.2 | -1.3 | -1.1 | -1.3 | -1.2 | -1.2 | -1.1 | -1.2 |
| Novelty place preference | 1.2 | 1.3 | 1.7 | -1.3 | -1.1 | -1.1 | -1.1 | -1.0 | -1.1 | -1.1 | -1.1 | -1.0 | -1.1 |
| Total zone transitions, NPP test | 1.2 | 1.7 | 2.5 | 1.6 | 1.3 | 1.1 | 1.6 | 1.3 | 1.2 | 1.1 | 1.3 | 1.1 | 1.3 |
| Time to tail flick, vehicle, before self-admin | 1.2 | 1.2 | 1.6 | 1.0 | 1.2 | 1.3 | 1.0 | 1.1 | 1.1 | 1.2 | 1.0 | 1.0 | 1.0 |
| Area under the delay curve | 1.2 | 1.3 | 1.6 | -1.1 | -1.1 | -1.1 | -0.9 | -1.2 | -1.1 | -1.1 | -1.2 | -1.3 | -1.0 |
| Delay disc. indifference point, 16s delay | 1.2 | 1.2 | 1.3 | -1.1 | -1.1 | -1.1 | -1.0 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -1.0 |
| Intermittent access intake day 1-15 change | 1.1 | 1.1 | 1.5 | 1.1 | 0.9 | 1.0 | 1.2 | 1.2 | 0.9 | 1.0 | 1.0 | 0.8 | 1.2 |
| Intermittent access day 1 locomotion | 1.1 | 1.1 | 1.4 | 1.1 | 1.0 | 1.0 | 1.0 | 1.1 | 1.0 | 1.0 | 1.1 | 1.2 | 1.0 |
| Cocaine induced anxiety | 1.1 | 1.3 | 1.5 | -1.0 | -1.2 | -1.2 | -1.1 | -1.0 | -1.2 | -1.2 | -1.2 | -1.1 | -1.1 |
| Baseline Anxiety | 1.1 | 1.2 | 1.4 | -0.9 | -1.2 | -1.1 | -1.0 | -1.1 | -1.1 | -1.1 | -1.2 | -1.0 | -1.0 |
| Short access day 1 total inactive lever presses | 1.1 | 1.2 | 1.7 | 1.1 | 1.0 | 1.0 | 1.3 | 1.1 | 1.1 | 1.0 | 1.1 | 1.1 | 1.3 |
| Stereotopy head waving bouts, day 7 | 1.1 | 1.2 | 2.2 | -1.2 | -1.0 | -1.1 | -1.5 | -1.1 | -1.2 | -1.1 | -1.1 | -0.9 | -1.0 |
| Distance traveled before self-admin | 1.1 | 1.2 | 1.6 | 1.0 | 1.0 | 1.0 | 1.3 | 1.1 | 1.0 | 1.0 | 1.1 | 1.2 | 1.1 |
| Delay discount exponential model param | 1.1 | 1.1 | 1.4 | 1.1 | 1.1 | 1.1 | 0.8 | 1.1 | 1.1 | 1.1 | 1.1 | 1.2 | 1.0 |
| Change in fecal boli incidents, locomotor task | 1.1 | 1.1 | 1.4 | -0.9 | -1.0 | -1.0 | -1.1 | -1.0 | -1.2 | -1.0 | -1.0 | -1.0 | -1.2 |
| Reaction time number correct | 1.0 | 1.5 | 2.4 | -1.0 | -1.1 | -1.1 | -1.6 | -1.2 | -1.3 | -1.2 | -1.1 | -1.2 | -1.5 |
| Reaction time trials correct on left | 1.0 | 1.5 | 2.4 | -1.0 | -1.1 | -1.1 | -1.6 | -1.2 | -1.3 | -1.2 | -1.1 | -1.2 | -1.5 |
| Pavlov. Cond. magazine entry latency | 1.0 | 1.1 | 1.6 | -1.0 | -1.1 | -1.0 | -1.2 | -1.1 | -1.0 | -1.0 | -1.1 | -1.0 | -1.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.0 | 1.3 | 1.4 | -1.1 | -1.2 | -1.1 | -1.2 | -1.2 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 |
| Locomotion velocity, NPP test | 1.0 | 1.4 | 2.0 | 1.4 | 1.2 | 1.1 | 1.4 | 1.3 | 1.1 | 1.1 | 1.3 | 1.0 | 1.1 |
| Delay discount hyperbolic model param | 1.0 | 1.0 | 1.3 | 1.1 | 1.0 | 1.0 | 0.8 | 1.1 | 1.0 | 1.0 | 1.0 | 1.2 | 1.0 |
| Cu content in liver | 1.0 | 1.2 | 1.7 | -0.5 | -1.2 | -1.3 | -0.8 | -0.9 | -1.3 | -1.3 | -1.2 | -1.2 | -1.0 |
| Std. dev. time between licks in bursts | 0.9 | 1.1 | 1.2 | 1.0 | 1.0 | 1.0 | 1.1 | 1.1 | 1.0 | 1.0 | 1.0 | 1.1 | 1.1 |
| Locomotor activity | 0.9 | 1.4 | 1.7 | 1.3 | 1.2 | 1.1 | 1.2 | 1.3 | 1.0 | 1.1 | 1.2 | 1.1 | 1.3 |
| Compulsive drug intake | 0.9 | 0.9 | 1.1 | -1.0 | -0.8 | -0.9 | -1.0 | -1.1 | -0.9 | -0.9 | -0.9 | -1.0 | -1.0 |
| Time in novel zone, NPP test | 0.9 | 1.0 | 1.4 | -1.2 | -1.0 | -1.0 | -1.0 | -0.9 | -1.0 | -1.0 | -1.0 | -0.8 | -1.0 |
| Light reinforcement 2 | 0.8 | 1.1 | 1.4 | 0.9 | 1.2 | 1.1 | 1.1 | 1.1 | 0.6 | 1.1 | 1.2 | 0.9 | 1.1 |
| Reaction time trials on left | 0.8 | 1.1 | 1.9 | -0.8 | -0.9 | -0.9 | -1.4 | -1.0 | -1.1 | -1.0 | -0.9 | -1.0 | -1.3 |
| Reaction time trials completed | 0.8 | 1.1 | 1.9 | -0.8 | -0.9 | -0.9 | -1.4 | -1.0 | -1.1 | -1.0 | -0.9 | -1.0 | -1.3 |
| Condit. Reinf. inactive responses | 0.7 | 0.9 | 1.1 | 0.8 | 1.0 | 1.0 | 0.8 | 1.0 | 1.0 | 1.0 | 1.0 | 1.1 | 0.9 |
| Pavlov. Cond. latency score | 0.7 | 0.8 | 1.0 | -0.9 | -0.9 | -0.9 | -1.0 | -1.0 | -0.9 | -0.9 | -0.9 | -0.9 | -0.8 |
| Intermittent access intake escalation | 0.7 | 0.7 | 1.1 | 0.9 | 0.7 | 0.8 | 1.0 | 1.0 | 0.7 | 0.8 | 0.8 | 0.6 | 1.0 |
| Bone: tissue strength | 0.7 | 0.7 | 1.1 | -0.7 | -0.8 | -0.8 | -0.8 | -0.9 | -0.7 | -0.8 | -0.8 | -0.8 | -1.1 |
| Soleus weight | 0.6 | 1.7 | 1.9 | -1.3 | -1.3 | -1.2 | -1.3 | -1.3 | -1.2 | -1.2 | -1.4 | -1.2 | -1.3 |
| Cocaine response after cond. not corrected | 0.6 | 0.7 | 0.9 | 0.9 | 0.8 | 0.9 | 1.0 | 0.8 | 0.9 | 0.9 | 0.8 | 0.6 | 0.8 |
| Condit. Reinf. lever reinforcers received | 0.6 | 0.9 | 1.0 | 0.8 | 1.0 | 1.0 | 0.7 | 1.0 | 1.0 | 1.0 | 1.0 | 0.9 | 0.8 |
| Pavlov. Cond. index score | 0.6 | 0.8 | 0.8 | -0.9 | -0.9 | -0.9 | -0.9 | -0.9 | -0.8 | -0.9 | -0.9 | -0.8 | -0.8 |
| Short access day 10 total infusions | 0.6 | 0.6 | 1.1 | 0.9 | 0.7 | 0.6 | 0.8 | 0.8 | 0.7 | 0.6 | 0.7 | 0.7 | 1.1 |
| Degree of sensitization distance | 0.6 | 0.6 | 0.9 | -0.9 | -0.7 | -0.8 | -0.7 | -0.9 | -0.8 | -0.8 | -0.9 | -0.7 | -0.7 |
| Time in closed arm after self-admin | 0.6 | 0.6 | 0.8 | -0.9 | -0.7 | -0.8 | -0.9 | -0.8 | -0.7 | -0.8 | -0.7 | -0.7 | -0.8 |
| Time in open arm before self-admin | 0.6 | 0.7 | 1.0 | -0.7 | -1.0 | -0.7 | -0.8 | -0.7 | -0.9 | -0.6 | -0.8 | -0.9 | -0.9 |
| Locomotion in novel chamber | 0.6 | 0.8 | 1.0 | -1.0 | -0.9 | -0.8 | -0.9 | -1.0 | -0.8 | -0.8 | -0.9 | -0.8 | -0.8 |
| Sr content in liver | 0.6 | 0.5 | 0.8 | -0.5 | -0.9 | -0.8 | -0.8 | -0.5 | -0.8 | -0.9 | -0.7 | -0.7 | -0.6 |
| Total sessions with >9 infusions | 0.5 | 0.5 | 1.1 | 0.6 | 0.7 | 0.6 | 0.8 | 0.8 | 0.5 | 0.6 | 0.8 | 0.6 | 1.1 |
| Stereotopy head waving duration, day 3 | 0.5 | 0.6 | 1.1 | -0.7 | -0.7 | -0.7 | -1.0 | -0.8 | -0.8 | -0.7 | -0.8 | -0.6 | -0.8 |
| Condit. Reinf. active responses | 0.5 | 0.6 | 0.8 | 0.9 | 0.8 | 0.7 | 0.8 | 0.8 | 0.7 | 0.7 | 0.9 | 0.6 | 0.8 |
| Bone: cortical tissue density | 0.5 | 0.6 | 0.8 | 0.7 | 0.8 | 0.8 | 0.9 | 0.8 | 0.8 | 0.8 | 0.7 | 0.8 | 0.7 |
| Active lever presses in extinction session 6 | 0.5 | 0.5 | 0.6 | -0.6 | -0.8 | -0.8 | -0.6 | -0.6 | -0.7 | -0.7 | -0.7 | -0.7 | -0.7 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 0.6 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.6 | 0.6 |
| Delta time to tail flick, vehicle, before/after SA | 0.5 | 0.5 | 0.8 | -0.6 | -0.8 | -0.9 | -0.6 | -0.6 | -0.8 | -0.9 | -0.6 | -0.6 | -0.6 |
| Time >=10cm from walls, locomotor time 2 | 0.5 | 0.5 | 0.8 | 0.9 | 0.7 | 0.7 | 0.7 | 0.8 | 0.6 | 0.7 | 0.7 | 0.6 | 0.8 |
| Cd content in liver | 0.5 | 0.5 | 1.0 | 0.8 | 0.7 | 0.6 | 1.0 | 0.8 | 0.5 | 0.5 | 0.7 | 0.6 | 0.8 |
| K content in liver | 0.5 | 0.5 | 0.7 | -0.7 | -0.7 | -0.7 | -0.4 | -0.7 | -0.8 | -0.7 | -0.8 | -0.8 | -0.5 |
| Left kidney weight | 0.4 | 1.2 | 1.8 | -0.9 | -0.9 | -1.2 | -1.1 | -1.1 | -1.1 | -1.1 | -1.0 | -1.3 | -1.0 |
| Reaction time mean | 0.4 | 0.6 | 0.9 | 0.6 | 0.7 | 0.7 | 0.9 | 0.6 | 0.9 | 0.7 | 0.7 | 0.7 | 0.9 |
| Conditioned locomotion | 0.4 | 0.4 | 0.6 | 0.6 | 0.7 | 0.6 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.8 | 0.8 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 0.7 | 0.5 | 0.6 | 0.7 | 0.8 | 0.6 | 0.7 | 0.7 | 0.6 | 0.8 | 0.5 |
| Short access total locomotion | 0.4 | 0.4 | 0.6 | 0.5 | 0.6 | 0.5 | 0.6 | 0.6 | 0.4 | 0.5 | 0.6 | 0.8 | 0.8 |
| Total zone transitions, hab. session 1 | 0.4 | 0.5 | 0.7 | 0.8 | 0.8 | 0.7 | 0.8 | 0.7 | 0.6 | 0.7 | 0.8 | 0.7 | 0.7 |
| Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 0.9 | 0.9 | 0.7 | 0.6 | 0.7 | 0.6 | 0.8 | 0.6 | 0.7 | 0.6 | 0.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.4 | 0.5 | 0.8 | -0.5 | -0.8 | -0.8 | -0.7 | -0.7 | -0.9 | -0.8 | -0.7 | -0.8 | -0.5 |
| Seeking ratio, delayed vs. immediate footshock | 0.4 | 0.5 | 0.8 | -0.6 | -0.7 | -0.7 | -0.7 | -0.6 | -0.6 | -0.7 | -0.7 | -0.9 | -0.6 |
| Se content in liver | 0.4 | 0.5 | 0.7 | 0.8 | 0.8 | 0.7 | 0.6 | 0.6 | 0.6 | 0.7 | 0.7 | 0.7 | 0.8 |
| Retroperitoneal fat weight | 0.3 | 0.9 | 1.7 | 1.3 | 0.9 | 0.8 | 1.2 | 1.0 | 0.8 | 0.8 | 0.9 | 0.6 | 1.2 |
| Delay discounting water rate 18 sec | 0.3 | 0.5 | 0.7 | -0.6 | -0.6 | -0.7 | -0.6 | -0.5 | -0.8 | -0.8 | -0.6 | -0.8 | -0.6 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 0.4 | 0.5 | 0.6 | 0.6 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 |
| Intermitt. access escalation Index | 0.3 | 0.2 | 0.5 | 0.6 | 0.5 | 0.4 | 0.6 | 0.7 | 0.3 | 0.4 | 0.5 | 0.5 | 0.4 |
| Intermittent access standard deviation | 0.3 | 0.4 | 0.6 | 0.7 | 0.5 | 0.6 | 0.8 | 0.7 | 0.5 | 0.6 | 0.6 | 0.5 | 0.7 |
| Context. condit. distance diff. score | 0.3 | 0.3 | 0.5 | -0.6 | -0.6 | -0.7 | -0.4 | -0.4 | -0.7 | -0.7 | -0.6 | -0.5 | -0.5 |
| Locomotion velocity, session 2 | 0.3 | 0.4 | 0.7 | 0.9 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.6 | 0.6 | 0.5 | 0.5 |
| Degree of sensitization stereotypy | 0.3 | 0.3 | 0.7 | -0.6 | -0.5 | -0.5 | -0.8 | -0.5 | -0.6 | -0.5 | -0.5 | -0.3 | -0.4 |
| Condit. Reinf. lever presses | 0.3 | 0.4 | 0.6 | -0.4 | -0.7 | -0.7 | -0.3 | -0.5 | -0.8 | -0.7 | -0.6 | -0.7 | -0.5 |
| Time in familiar zone, hab. session 1 | 0.3 | 0.3 | 0.7 | 0.8 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 |
| Time in novel zone, hab. session 1 | 0.3 | 0.3 | 0.6 | -0.8 | -0.5 | -0.5 | -0.7 | -0.5 | -0.5 | -0.5 | -0.5 | -0.4 | -0.5 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 0.5 | 0.5 | 0.5 | 0.4 | 0.5 | 0.7 | 0.4 | 0.4 | 0.6 | 0.6 | 0.5 |
| Total zone transitions, hab. session 2 | 0.3 | 0.4 | 0.7 | 0.8 | 0.7 | 0.5 | 0.8 | 0.7 | 0.5 | 0.5 | 0.7 | 0.5 | 0.6 |
| Bone: cortical apparent density | 0.3 | 0.4 | 0.6 | 0.6 | 0.6 | 0.7 | 0.8 | 0.7 | 0.7 | 0.7 | 0.6 | 0.7 | 0.6 |
| Bone: cortical thickness | 0.3 | 0.3 | 0.4 | -0.7 | -0.6 | -0.6 | -0.4 | -0.5 | -0.6 | -0.6 | -0.6 | -0.6 | -0.4 |
| Extinction: sum of active levers before priming | 0.3 | 0.3 | 0.5 | -0.5 | -0.6 | -0.6 | -0.7 | -0.5 | -0.5 | -0.6 | -0.6 | -0.6 | -0.7 |
| Time in open arm after self-admin | 0.3 | 0.3 | 0.4 | 0.6 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 |
| Delay disc. indifference point, 4s delay | 0.3 | 0.3 | 0.6 | -0.7 | -0.5 | -0.5 | -0.3 | -0.6 | -0.5 | -0.5 | -0.5 | -0.8 | -0.6 |
| Rest time, locomotor task time 1 | 0.3 | 0.3 | 0.4 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.4 | 0.6 |
| Food seeking constrained by brief footshock | 0.3 | 0.3 | 0.7 | 0.8 | 0.4 | 0.5 | 0.6 | 0.6 | 0.4 | 0.5 | 0.4 | 0.6 | 0.7 |
| Glucose | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.5 | -0.4 | -0.6 | -0.5 | -0.5 | -0.6 | -0.4 | -0.3 |
| Mean time between licks in bursts | 0.2 | 0.3 | 0.8 | 0.9 | 0.5 | 0.5 | 0.6 | 0.6 | 0.5 | 0.5 | 0.5 | 0.4 | 0.3 |
| Indifference point AUC | 0.2 | 0.2 | 0.6 | 0.2 | 0.3 | 0.5 | 0.2 | 0.3 | 0.5 | 0.5 | 0.3 | 0.7 | 0.5 |
| Reaction time mean AUC | 0.2 | 0.3 | 0.4 | 0.4 | 0.5 | 0.5 | 0.7 | 0.3 | 0.7 | 0.5 | 0.5 | 0.4 | 0.7 |
| Condit. Reinf. active responses | 0.2 | 0.3 | 0.5 | 0.4 | 0.6 | 0.6 | 0.4 | 0.6 | 0.7 | 0.6 | 0.6 | 0.6 | 0.5 |
| Short access total infusions | 0.2 | 0.2 | 0.7 | 0.5 | 0.4 | 0.3 | 0.5 | 0.6 | 0.3 | 0.3 | 0.5 | 0.5 | 0.8 |
| Short access day 10 total locomotion | 0.2 | 0.3 | 0.7 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.4 | 0.5 | 0.5 | 0.8 | 0.5 |
| Locomotion velocity, session 7 | 0.2 | 0.2 | 0.4 | 0.5 | 0.5 | 0.3 | 0.6 | 0.6 | 0.4 | 0.3 | 0.6 | 0.3 | 0.4 |
| Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | -0.4 | -0.5 | -0.6 | -0.4 | -0.4 | -0.5 | -0.6 | -0.5 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.7 | 0.5 | 0.4 | 0.6 | 0.6 | 0.4 | 0.4 | 0.5 | 0.3 | 0.2 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.5 | 0.6 | 0.3 | 0.3 | 0.5 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | 0.7 |
| Breakpoint value in progressive ratio session | 0.2 | 0.2 | 0.4 | -0.6 | -0.5 | -0.5 | -0.4 | -0.4 | -0.5 | -0.5 | -0.5 | -0.5 | -0.5 |
| Distance traveled after self-admin | 0.2 | 0.2 | 0.3 | 0.4 | 0.4 | 0.3 | 0.5 | 0.4 | 0.6 | 0.4 | 0.5 | 0.5 | 0.5 |
| Delta time in closed arm before/after self-admin | 0.2 | 0.2 | 0.4 | -0.4 | -0.4 | -0.4 | -0.6 | -0.5 | -0.5 | -0.4 | -0.4 | -0.6 | -0.5 |
| Time to tail flick, vehicle, after self-admin | 0.2 | 0.2 | 0.3 | -0.4 | -0.5 | -0.5 | -0.3 | -0.3 | -0.5 | -0.6 | -0.3 | -0.3 | -0.5 |
| Delta time to tail flick, test, before/after SA | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.4 | -0.5 | -0.5 | -0.5 | -0.5 | -0.4 | -0.3 | -0.4 |
| Time >=10cm from walls, locomotor time 1 | 0.2 | 0.2 | 0.4 | -0.3 | -0.4 | -0.4 | -0.4 | -0.4 | -0.5 | -0.4 | -0.4 | -0.6 | -0.4 |
| Total resting periods, locomotor time 1 | 0.2 | 0.2 | 0.3 | 0.6 | 0.4 | 0.4 | 0.6 | 0.5 | 0.5 | 0.4 | 0.6 | 0.2 | 0.5 |
| Distance moved, locomotor task time 2 | 0.2 | 0.2 | 0.3 | 0.6 | 0.5 | 0.5 | 0.3 | 0.5 | 0.3 | 0.5 | 0.4 | 0.4 | 0.3 |
| Epididymis fat weight | 0.1 | 0.3 | 0.5 | -0.5 | -0.5 | -0.4 | -0.4 | -0.6 | -0.5 | -0.4 | -0.6 | -0.7 | -0.7 |
| Tail length | 0.1 | 0.2 | 0.3 | 0.2 | 0.5 | 0.4 | 0.5 | 0.2 | 0.4 | 0.4 | 0.4 | 0.6 | 0.6 |
| Number of licking bursts | 0.1 | 0.1 | 0.4 | 0.2 | 0.3 | 0.3 | 0.5 | 0.3 | 0.3 | 0.3 | 0.2 | 0.6 | 0.6 |
| Median of all reaction times | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | -0.3 | -0.1 | -0.4 | -0.2 | -0.3 | -0.3 | -0.3 | -0.1 |
| Social response proportion | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 | 0.4 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.4 |
| Saline control response | 0.1 | 0.1 | 0.1 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.2 | -0.3 | -0.3 | -0.2 | -0.4 |
| Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.4 |
| One hour access (0.3 mA shock) | 0.1 | 0.1 | 0.3 | 0.5 | 0.2 | 0.3 | 0.5 | 0.5 | 0.2 | 0.3 | 0.3 | 0.2 | 0.6 |
| One hour access (shock baseline) | 0.1 | 0.1 | 0.2 | 0.4 | 0.0 | 0.1 | 0.4 | 0.4 | 0.1 | 0.1 | 0.1 | 0.1 | 0.5 |
| Number of responses in last shaping day | 0.1 | 0.1 | 0.3 | -0.3 | -0.4 | -0.4 | 0.0 | -0.1 | -0.5 | -0.4 | -0.4 | -0.3 | -0.2 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | 0.3 | 0.2 | 0.4 | 0.2 | 0.3 | 0.5 | 0.1 | 0.2 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.2 | 0.4 | -0.3 | -0.3 | -0.4 | -0.4 | -0.2 | -0.5 | -0.4 | -0.2 | -0.6 | -0.5 |
| Incentive salience index mean | 0.1 | 0.1 | 0.2 | -0.1 | -0.2 | -0.3 | -0.1 | -0.2 | -0.4 | -0.3 | -0.1 | -0.4 | -0.2 |
| Locomotion velocity, hab. session 2 | 0.1 | 0.1 | 0.3 | 0.5 | 0.3 | 0.1 | 0.4 | 0.4 | 0.2 | 0.1 | 0.3 | 0.0 | 0.1 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.3 | -0.0 | -0.5 | -0.4 | -0.4 | -0.3 | -0.4 | -0.4 | -0.4 | -0.4 | -0.2 |
| Pavlov. Cond. index score | 0.1 | 0.2 | 0.4 | -0.2 | -0.5 | -0.5 | -0.4 | -0.4 | -0.6 | -0.5 | -0.4 | -0.5 | -0.2 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.3 | -0.2 | -0.5 | -0.4 | -0.3 | -0.4 | -0.6 | -0.4 | -0.4 | -0.5 | -0.1 |
| Bone: elastic work | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.4 | 0.2 | 0.3 | 0.4 | 0.1 | -0.0 |
| Bone: trabecular thickness | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.3 | 0.2 | 0.3 | 0.3 | 0.3 | 0.5 | 0.1 | 0.3 |
| Bone: trabecular tissue density | 0.1 | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | 0.3 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.3 |
| Delta distance traveled before/after self-admin | 0.1 | 0.1 | 0.1 | -0.2 | -0.2 | -0.3 | -0.3 | -0.3 | -0.1 | -0.3 | -0.3 | -0.3 | -0.2 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.2 | 0.3 | 0.3 | 0.2 |
| Time to tail flick, test, after self-admin | 0.1 | 0.2 | 0.2 | -0.4 | -0.4 | -0.4 | -0.3 | -0.4 | -0.3 | -0.4 | -0.4 | -0.4 | -0.4 |
| Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | -0.3 | -0.3 | -0.1 | -0.3 | -0.3 | -0.2 | -0.2 | -0.1 |
| Co content in liver | 0.1 | 0.1 | 0.6 | 0.3 | 0.3 | 0.0 | 0.6 | 0.3 | 0.1 | 0.1 | 0.2 | 0.3 | 0.8 |
| Fe content in liver | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.2 | 0.2 | 0.2 | 0.3 | 0.6 |
| Rb content in liver | 0.1 | 0.2 | 0.4 | 0.3 | 0.3 | 0.4 | 0.6 | 0.4 | 0.2 | 0.4 | 0.2 | 0.4 | 0.6 |
| BMI without tail | 0.0 | 0.1 | 0.2 | -0.5 | -0.4 | -0.2 | -0.0 | -0.5 | -0.3 | -0.2 | -0.4 | -0.2 | 0.1 |
| Heart weight | 0.0 | 0.0 | 0.1 | -0.0 | -0.2 | -0.2 | -0.3 | -0.1 | -0.2 | -0.3 | -0.2 | -0.3 | -0.2 |
| Times rat made contact with spout | 0.0 | 0.0 | 0.1 | 0.2 | 0.0 | 0.0 | 0.1 | 0.2 | 0.0 | 0.0 | 0.0 | -0.0 | 0.3 |
| Mean num. licks in bursts | 0.0 | 0.0 | 0.1 | 0.4 | 0.1 | 0.2 | -0.0 | 0.2 | 0.1 | 0.2 | 0.2 | -0.2 | -0.1 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.0 | -0.2 | 0.1 | -0.0 | -0.0 | 0.1 | -0.1 | -0.1 |
| Social time | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.0 | 0.1 | -0.0 | 0.1 |
| Conditioned locomotion | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.2 | -0.2 | -0.0 | -0.1 | -0.2 | -0.2 | 0.0 | -0.2 |
| Cocaine response after cond. corrected | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | 0.2 | 0.0 | 0.1 | 0.1 | 0.0 | -0.2 | 0.0 |
| Condit. Reinf. active minus inactive responses | 0.0 | 0.1 | 0.1 | 0.0 | 0.3 | 0.3 | 0.0 | 0.2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.1 | -0.0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.0 | -0.0 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.0 | 0.2 | -0.0 | 0.0 | -0.1 | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | -0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.0 | 0.0 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | -0.0 | 0.0 | -0.0 | 0.0 |
| Incentive Sensitization - Responses | 0.0 | 0.0 | 0.1 | -0.4 | -0.2 | -0.2 | -0.1 | -0.3 | -0.1 | -0.2 | -0.3 | -0.3 | -0.1 |
| Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.0 | 0.1 | -0.1 | -0.0 | -0.0 | -0.1 | -0.2 | 0.0 |
| Short access day 1 total infusions | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.1 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.2 |
| Short access day 1 locomotion | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.0 | 0.2 | 0.2 | 0.2 | 0.4 |
| Locomotion velocity, session 8 | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | -0.1 | 0.1 | -0.0 | -0.1 | -0.1 | -0.1 | -0.1 | -0.0 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | 0.2 | 0.1 | 0.1 | 0.1 | 0.1 | -0.0 | -0.1 |
| Locomotion velocity, hab. session 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.1 | 0.0 | -0.0 | -0.0 | 0.1 | -0.1 | -0.2 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | 0.2 | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | -0.2 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | -0.1 | 0.0 | -0.1 | 0.0 | 0.1 | -0.1 | -0.0 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.0 | -0.1 | 0.0 | -0.0 | -0.0 | -0.0 | 0.1 | -0.0 | -0.1 | 0.1 | -0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.0 | 0.1 | 0.3 | 0.0 | 0.1 | 0.1 | 0.1 | 0.0 | 0.1 | 0.1 | -0.0 | 0.2 |
| Delta ambulatory time before/after self-admin | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.2 | -0.1 | -0.2 | -0.0 | -0.1 | -0.2 | -0.2 | -0.1 |
| Bouts of movement, locomotor time 1 | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.0 | 0.1 | 0.0 | -0.1 | -0.0 | 0.1 | -0.3 | -0.0 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.0 | 0.1 | -0.1 | 0.0 | -0.2 |
| Rest time, locomotor task time 2 | 0.0 | 0.1 | 0.1 | -0.2 | -0.3 | -0.3 | -0.0 | -0.2 | -0.1 | -0.3 | -0.3 | -0.3 | -0.2 |
| Locomotion in novel chamber post-restriction | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.1 | -0.1 | -0.1 | -0.2 | -0.1 | -0.1 | -0.1 | -0.2 |
| Progressive ratio | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | 0.2 | 0.3 |
| Seeking ratio, punishment vs. effort | 0.0 | 0.0 | 0.0 | 0.2 | -0.0 | -0.0 | 0.2 | 0.2 | -0.1 | -0.0 | -0.0 | 0.0 | 0.0 |
| Run reversals in cocaine runway, females | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.2 | -0.0 | -0.0 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 |
| Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.1 | -0.0 | -0.0 | 0.3 | 0.1 | 0.1 | 0.2 | 0.1 |
| Mg content in liver | 0.0 | 0.0 | 0.1 | -0.3 | -0.0 | -0.0 | 0.0 | -0.3 | -0.1 | -0.1 | -0.1 | -0.1 | 0.1 |
| Mn content in liver | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.1 | -0.3 | -0.2 | -0.2 | -0.0 | 0.1 | 0.0 | -0.2 |
| Na content in liver | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | -0.0 | 0.5 | 0.1 | -0.0 | -0.0 | 0.0 | 0.0 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.