Hub : Genes

Clic2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability ENSRNOG00000000728 0.39 0.12 0.0e+00 0.41 0.42 0.43 0.42 7.2e-49 3.3e-51 2.7e-51 5.3e-51
2 BLA gene expression ENSRNOG00000000728 0.18 0.1 1.6e-04 0.04 0.07 0.05 0.04 2.8e-03 8.4e-05 1.1e-03 2.2e-03
3 Brain gene expression ENSRNOG00000000728 0.22 0.09 0.0e+00 0.18 0.2 0.19 0.2 2.3e-16 4.9e-18 2.5e-17 2.6e-18
4 Brain mRNA stability ENSRNOG00000000728 0.07 0.04 3.7e-08 0.07 0.06 0.06 0.05 1.0e-06 3.5e-06 2.7e-06 1.2e-05
5 LHb gene expression ENSRNOG00000000728 0.51 0.13 5.8e-08 0.2 0.23 0.18 0.22 1.5e-05 4.5e-06 4.6e-05 5.0e-06
6 Liver gene expression ENSRNOG00000000728 0.25 0.1 0.0e+00 0.23 0.23 0.21 0.23 2.9e-25 6.3e-25 1.2e-22 7.5e-25
7 Liver mRNA stability ENSRNOG00000000728 0.22 0.09 0.0e+00 0.15 0.15 0.15 0.15 5.7e-16 1.4e-16 4.7e-16 2.3e-16
8 PL gene expression ENSRNOG00000000728 0.14 0.07 5.0e-07 0.02 0.06 0.05 0.06 1.0e-02 1.3e-05 8.6e-05 1.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail1.85.88.72.9-1.3-2.72.9-1.9-2.82.3-1.8
BMI without tail0.61.31.91.1-1.0-1.40.9-1.3-1.40.6-1.1
Body weight5.523.227.84.6-4.2-5.34.8-5.0-5.24.7-4.7
Epididymis fat weight1.63.811.32.03.4-1.01.12.1-1.3-0.52.6
Glucose2.33.510.7-0.4-3.3-0.60.2-2.6-0.41.7-2.7
Heart weight0.40.61.00.4-0.9-0.90.6-1.0-0.80.6-0.8
Left kidney weight0.92.74.70.9-2.0-1.61.1-2.2-1.31.5-2.1
Right kidney weight2.16.18.71.7-2.7-2.52.1-3.0-2.22.5-2.9
Tail length1.64.911.20.5-3.4-1.60.8-3.2-1.41.5-3.1
Length with tail2.69.515.31.9-3.7-2.92.3-3.9-2.62.8-3.8
Length without tail4.08.710.72.4-2.9-2.93.0-3.3-2.63.1-3.3
Liver weight, left1.42.24.90.5-2.2-1.20.9-1.9-1.11.3-1.9
Liver weight, right2.44.010.80.1-3.3-1.10.7-2.9-0.71.2-3.0
Parametrial fat weight1.73.45.82.4-0.7-2.22.1-1.4-2.11.9-1.2
Retroperitoneal fat weight0.20.51.11.1-0.2-1.00.8-0.5-0.80.5-0.4
Intraocular pressure0.20.30.70.70.0-0.60.7-0.1-0.80.8-0.1
Extensor digitorum longus weight0.31.33.10.2-1.8-0.60.6-1.6-0.41.1-1.5
Soleus weight1.02.99.4-1.1-3.10.1-0.5-2.30.60.8-2.5
Tibialis anterior weight0.31.01.9-0.31.40.8-0.71.20.6-1.11.3
Tibia length2.16.09.81.4-3.1-2.12.0-3.1-1.92.2-3.1
Number of licking bursts0.30.30.8-0.9-0.10.6-0.70.10.7-0.70.1
Food consumed during 24 hour testing period1.62.02.51.0-1.3-1.61.3-1.5-1.51.5-1.5
Times rat made contact with spout2.73.15.2-1.02.21.4-1.32.21.2-1.82.3
Mean time between licks in bursts1.11.64.5-0.2-2.1-0.60.4-1.7-0.31.1-1.8
Mean num. licks in bursts0.30.41.10.61.0-0.20.40.8-0.40.10.9
Std. dev. time between licks in bursts0.60.72.1-0.7-1.50.0-0.3-1.00.20.3-1.2
Water consumed over 24 hours0.10.10.2-0.50.30.2-0.50.30.3-0.50.2
Indifference point 0 sec0.20.41.0-0.00.90.4-0.30.70.1-0.51.0
Indifference point AUC0.20.20.6-0.2-0.80.10.1-0.70.3-0.2-0.6
Indifference point function ln k0.50.82.0-1.4-0.11.0-1.20.31.0-0.70.2
Indifference point function log k0.50.82.0-1.4-0.11.0-1.20.31.0-0.70.2
Delay discounting total patch changes 0 sec0.40.61.4-0.21.10.6-0.50.90.3-0.81.2
Delay discounting total patch changes 12 sec0.40.51.1-0.01.00.6-0.30.80.3-0.81.1
Delay discounting total patch changes 18 sec0.30.41.20.61.10.10.20.8-0.1-0.11.0
Delay discounting total patch changes 24 sec2.73.47.7-0.42.81.2-1.02.41.0-1.72.7
Delay discounting total patch changes 6 sec0.40.61.80.71.3-0.10.20.8-0.4-0.51.2
Delay discounting time to switch 0 sec0.81.32.61.61.3-1.21.10.7-1.40.60.8
Delay discounting water rate 0 sec0.00.00.2-0.2-0.20.4-0.2-0.20.3-0.0-0.0
Delay discounting water rate 12 sec0.10.10.3-0.50.10.5-0.50.20.3-0.10.1
Delay discounting water rate 18 sec0.20.30.50.4-0.6-0.70.4-0.6-0.60.7-0.6
Delay discounting water rate 24 sec0.10.10.20.4-0.2-0.30.5-0.3-0.40.4-0.3
Delay discounting water rate 6 sec0.50.70.9-0.70.90.9-0.81.00.8-0.80.9
Locomotor activity2.74.29.00.7-3.0-1.71.2-2.7-1.42.0-2.7
Locomotor testing distance1.11.83.10.8-1.8-1.21.0-1.6-1.11.4-1.6
Locomotor testing rearing1.52.33.90.9-2.0-1.31.1-1.8-1.21.6-1.8
Light reinforcement 10.10.20.70.30.80.10.10.5-0.1-0.20.6
Light reinforcement 22.33.03.71.7-1.3-1.91.9-1.8-1.81.8-1.6
Reaction time number correct0.91.22.91.70.4-1.21.6-0.1-1.40.80.1
Reaction time mean minus median3.34.311.00.1-3.3-1.20.6-2.8-1.02.0-3.0
Reaction time mean minus median AUC2.32.97.40.1-2.7-0.90.4-2.3-0.81.7-2.5
Reaction time num false alarms2.63.65.7-2.01.12.1-2.41.42.1-2.21.4
Reaction time num false alarms AUC2.73.86.3-2.30.82.2-2.51.22.3-2.31.2
Reaction time trials correct on left0.91.22.91.70.4-1.21.6-0.1-1.40.80.1
Reaction time trials on left0.91.32.91.70.3-1.21.7-0.2-1.40.80.0
Reaction time mean2.33.29.3-0.5-3.1-0.60.1-2.3-0.31.7-2.7
Reaction time mean AUC2.53.49.7-0.4-3.1-0.60.2-2.4-0.41.8-2.7
Median of all reaction times1.41.95.8-0.7-2.4-0.3-0.1-1.7-0.01.3-2.1
Reaction time omissions1.11.54.3-0.3-2.1-0.50.3-1.6-0.11.1-1.9
Reaction time false alarm rate3.75.29.8-2.90.42.6-3.11.12.8-2.51.0
Reaction time premature initiation rate1.01.31.91.0-0.8-1.41.2-1.1-1.41.1-1.0
Reaction time premature initiations1.72.44.21.9-0.6-1.92.0-1.1-2.01.4-0.9
Std. dev. reaction times2.33.19.4-0.5-3.1-0.60.1-2.4-0.41.4-2.7
Reaction time trials completed0.91.32.91.70.3-1.21.7-0.2-1.40.80.0
Reaction time trials AUC1.01.43.21.80.3-1.41.7-0.2-1.50.9-0.1
Social response proportion0.20.20.8-0.3-0.90.1-0.1-0.70.10.3-0.7
Social responses0.10.20.7-0.0-0.80.10.1-0.6-0.10.2-0.6
Social time0.91.23.6-0.8-1.90.0-0.4-1.30.30.7-1.6
Conditioned locomotion1.82.23.41.7-0.7-1.81.8-1.2-1.81.3-1.1
Cocaine response after cond. corrected0.20.20.50.10.70.2-0.10.60.2-0.30.6
Cocaine response after cond. not corrected0.50.50.80.5-0.9-0.70.6-0.9-0.60.6-0.9
Cocaine response before conditioning3.84.78.11.2-2.9-1.91.6-2.8-1.81.8-2.7
Saline control response1.52.03.51.9-0.6-1.71.6-1.0-1.91.4-0.8
Condit. Reinf. active minus inactive responses1.01.21.50.9-1.1-1.21.2-1.2-1.20.9-1.1
Condit. Reinf. active-inactive response ratio2.02.12.91.3-1.3-1.61.7-1.5-1.51.3-1.4
Condit. Reinf. active responses0.10.20.30.2-0.6-0.30.4-0.5-0.40.3-0.4
Condit. Reinf. inactive responses0.00.00.10.1-0.3-0.10.0-0.1-0.10.4-0.2
Condit. Reinf. lever presses0.00.00.1-0.3-0.20.2-0.10.00.10.10.0
Condit. Reinf. lever reinforcers received0.10.10.30.1-0.5-0.30.3-0.4-0.40.3-0.4
Pavlov. Cond. lever latency0.00.00.00.1-0.1-0.1-0.0-0.2-0.1-0.0-0.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.6-0.20.2-0.3-0.10.4-0.3-0.1
Pavlov. Cond. change in total contacts0.00.00.10.10.0-0.20.2-0.0-0.2-0.10.1
Pavlov. Cond. index score0.00.00.2-0.4-0.20.2-0.2-0.10.2-0.1-0.0
Pavlov. Cond. latency score0.00.10.2-0.4-0.10.2-0.20.10.3-0.20.1
Pavlov. Cond. lever contacts0.10.10.30.50.1-0.40.50.0-0.40.40.1
Pavlov. Cond. magazine entry number0.00.00.00.0-0.00.1-0.10.10.10.00.0
Pavlov. Cond. intertrial magazine entries0.70.92.0-1.4-0.51.1-1.20.01.3-0.8-0.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.3-0.20.1-0.1-0.10.2-0.1-0.1
Pavlov. Cond. response bias0.10.10.20.3-0.1-0.30.4-0.1-0.40.3-0.0
Conditioned reinforcement - actives0.60.61.41.20.0-1.00.8-0.3-1.10.8-0.2
Conditioned reinforcement - inactives0.10.10.20.30.5-0.3-0.10.3-0.3-0.20.3
Conditioned locomotion2.42.93.92.0-1.0-1.92.0-1.4-1.91.9-1.2
Intermittent access intake day 1-15 change0.70.71.21.1-0.5-0.91.1-0.7-0.90.7-0.7
Intermittent access intake escalation1.31.31.71.1-1.2-1.01.2-1.2-1.01.2-1.3
Intermittent access intake escalation 21.61.64.00.3-2.0-0.60.7-1.6-0.41.2-1.8
Intermitt. access day 1 inactive lever presses0.10.10.4-0.4-0.6-0.1-0.5-0.30.10.2-0.5
Intermitt. access day 15 inactive lever presses0.20.20.4-0.0-0.6-0.5-0.0-0.6-0.30.2-0.6
Intermitt. access escalation Index2.42.23.0-1.11.41.7-1.21.71.6-1.51.4
Intermittent access day 1 total infusions0.20.20.50.30.7-0.3-0.10.5-0.40.10.5
Intermittent access day 15 total infusions1.41.63.01.7-0.1-1.51.5-0.6-1.61.3-0.5
Intermittent access terminal intake (last 3 days)1.31.52.81.7-0.3-1.51.4-0.6-1.61.2-0.5
Intermittent access total infusions1.31.42.71.6-0.1-1.61.2-0.5-1.61.2-0.4
Intermittent access day 1 locomotion1.01.01.71.1-0.7-1.30.9-0.8-1.21.1-0.9
Intermittent access day 15 total locomotion4.34.65.22.0-1.9-2.32.2-2.2-2.12.3-2.1
Intermittent access total locomotion4.95.66.72.2-2.0-2.62.3-2.3-2.42.6-2.3
Intermittent access standard deviation1.31.42.31.5-0.5-1.41.5-0.9-1.51.1-0.7
Cocaine induced anxiety1.31.43.10.2-1.8-0.80.6-1.3-0.61.7-1.6
Post-drug Anxiety0.50.61.6-0.3-1.3-0.10.2-0.90.10.8-1.1
Baseline Anxiety2.12.23.6-1.21.41.6-1.21.51.5-1.91.5
Lifetime Intake0.70.81.61.2-0.1-1.20.8-0.4-1.30.9-0.3
Incentive Sensitization - Responses0.80.81.6-0.41.30.5-0.71.20.5-0.81.2
Incentive Sensitization - Breakpoint0.70.71.4-0.31.20.4-0.61.10.4-0.71.1
Progressive ratio test 1 active lever presses0.10.10.30.60.4-0.30.50.2-0.30.20.1
Progressive ratio test 1 breakpoint0.20.20.50.70.4-0.30.60.3-0.40.20.2
Progressive ratio test 1 inactive lever presses0.40.41.40.31.20.00.00.9-0.0-0.31.0
Progressive ratio test 2 active lever presses0.30.30.70.60.8-0.30.30.6-0.40.10.6
Progressive ratio test 2 breakpoint0.30.31.00.51.0-0.20.10.8-0.3-0.00.8
Progressive ratio test 2 inactive lever presses0.30.30.60.7-0.3-0.80.5-0.5-0.70.6-0.4
Total sessions with >9 infusions0.20.20.40.7-0.1-0.60.5-0.3-0.50.4-0.2
Short access day 1 total inactive lever presses0.40.51.5-0.5-1.2-0.1-0.6-0.80.10.5-1.0
Short access day 10 total inactive lever presses0.30.41.2-1.1-0.20.6-1.00.30.6-0.20.1
Short access day 1 total infusions0.10.10.3-0.20.30.1-0.50.30.1-0.20.3
Short access day 10 total infusions0.20.20.50.50.0-0.70.2-0.2-0.70.4-0.1
Short access total infusions0.10.10.40.4-0.0-0.60.1-0.2-0.60.3-0.1
Short access day 1 locomotion0.10.10.10.30.3-0.00.10.30.00.20.3
Short access day 10 total locomotion0.40.51.6-0.4-1.3-0.1-0.3-0.90.10.3-1.0
Short access total locomotion0.10.10.20.3-0.4-0.30.2-0.4-0.20.3-0.5
Compulsive drug intake2.92.93.9-1.81.51.5-2.01.81.7-1.71.6
One hour access (0.3 mA shock)0.00.10.2-0.20.3-0.1-0.40.3-0.00.20.2
One hour access (shock baseline)2.52.93.81.5-1.6-1.71.6-1.8-1.71.9-1.7
Number of responses in last shaping day0.00.00.10.2-0.3-0.2-0.1-0.3-0.2-0.1-0.2
Context. condit. distance diff. score0.60.71.8-0.9-1.40.3-0.6-0.70.50.8-1.0
Locomotion velocity, session 10.20.20.6-0.7-0.40.6-0.5-0.10.7-0.4-0.2
Locomotion distance, session 11.82.32.8-1.21.61.6-1.41.71.5-1.61.6
Locomotion velocity, session 21.61.93.4-1.80.51.6-1.50.81.6-1.80.7
Locomotion distance, session 21.31.92.7-1.60.91.6-1.51.21.6-1.41.1
Locomotion velocity, session 30.70.81.4-0.50.90.8-0.71.00.7-1.21.0
Locomotion distance, session 32.02.23.0-1.51.21.7-1.71.41.6-1.41.3
Stereotopy head waving bouts, day 30.30.41.3-0.3-1.2-0.20.1-0.9-0.00.2-1.0
Stereotopy head waving duration, day 30.30.41.2-0.0-1.1-0.40.4-0.9-0.30.2-0.9
Locomotion velocity, session 70.50.51.1-0.90.11.0-0.80.41.0-0.20.3
Locomotion distance, session 74.15.26.7-2.12.02.6-2.32.32.5-2.12.2
Stereotopy head waving bouts, day 70.40.51.0-1.0-0.20.7-0.90.00.8-1.00.0
Stereotopy head waving duration, day 70.30.41.2-0.2-1.1-0.20.0-1.0-0.10.0-1.0
Locomotion velocity, session 81.61.94.8-1.8-2.20.7-1.0-1.41.0-0.2-1.6
Locomotion distance, session 80.91.43.5-1.9-0.31.5-1.60.31.6-0.40.1
Degree of sensitization distance0.10.10.2-0.3-0.50.20.1-0.30.20.1-0.3
Degree of sensitization stereotypy0.80.91.6-1.20.01.1-1.20.31.1-1.20.2
Condit. Reinf. active minus inactive responses0.10.10.2-0.5-0.20.3-0.5-0.00.4-0.2-0.1
Condit. Reinf. active-inactive response ratio0.00.00.00.20.2-0.1-0.00.1-0.1-0.20.1
Condit. Reinf. active responses0.00.00.0-0.2-0.10.0-0.20.00.10.2-0.1
Condit. Reinf. inactive responses0.40.51.2-0.31.10.5-0.41.10.4-0.21.0
Incentive salience index mean0.40.51.1-1.1-0.80.5-0.8-0.40.70.1-0.7
Condit. Reinf. lever presses0.60.82.4-1.6-0.60.8-1.1-0.01.1-0.0-0.5
Time in familiar zone, hab. session 12.22.14.6-0.22.10.9-0.72.00.8-1.22.1
Time in novel zone, hab. session 15.55.38.31.2-2.9-2.01.8-2.9-1.82.5-2.8
Total zone transitions, hab. session 10.40.50.8-0.80.40.9-0.90.60.9-0.60.6
Total locomotion distance, hab. session 10.71.01.2-1.00.91.1-1.11.01.0-0.80.9
Locomotion velocity, hab. session 11.52.22.5-1.41.41.5-1.61.51.5-1.51.4
Time in familiar zone, hab. session 20.20.20.80.30.90.1-0.00.7-0.2-0.10.7
Time in novel zone, hab. session 20.40.40.80.5-0.8-0.50.7-0.9-0.50.5-0.7
Total zone transitions, hab. session 20.40.50.6-0.50.80.8-0.60.70.7-0.70.7
Total locomotion distance, hab. session 20.40.50.9-0.51.00.7-0.70.90.6-0.50.8
Locomotion velocity, hab. session 20.91.21.6-1.01.21.2-1.21.31.1-0.91.1
Novel to familiar place preference ratio0.10.10.3-0.10.60.3-0.10.40.2-0.40.5
Novelty place preference0.00.00.00.00.20.10.10.10.0-0.20.2
Time in novel zone, NPP test0.10.10.20.3-0.2-0.30.4-0.3-0.30.2-0.2
Total zone transitions, NPP test0.20.20.4-0.50.30.6-0.60.40.6-0.30.4
Total locomotion distance, NPP test0.20.20.80.10.90.3-0.20.70.2-0.00.7
Locomotion velocity, NPP test0.81.12.0-0.61.40.9-0.91.40.8-0.71.4
Pavlov. Cond. lever latency1.41.84.42.11.2-1.21.60.5-1.60.80.7
Pavlov. Cond. magazine entry latency1.01.43.4-1.8-0.41.3-1.50.31.5-1.0-0.0
Pavlov. Cond. change in total contacts0.40.40.9-0.7-1.00.2-0.4-0.80.4-0.2-0.8
Pavlov. Cond. index score1.51.95.1-2.3-0.91.4-1.8-0.11.8-1.1-0.4
Pavlov. Cond. latency score1.82.35.9-2.4-0.91.6-1.9-0.12.0-1.2-0.4
Pavlov. Cond. lever contacts1.01.22.6-1.6-1.40.8-1.2-0.81.1-0.3-1.0
Pavlov. Cond. magazine entry number0.50.71.71.30.2-0.91.1-0.3-1.10.7-0.1
Pavlov. Cond. intertrial magazine entries0.20.20.60.70.3-0.60.50.0-0.60.50.1
Pavlov. Cond. lever-magazine prob. diff.1.72.15.6-2.4-0.71.5-1.90.11.9-1.2-0.2
Pavlov. Cond. response bias0.60.82.0-1.4-0.90.7-1.0-0.41.0-0.4-0.6
Bone: apparent density0.20.41.00.71.0-0.10.30.7-0.30.40.9
Bone surface1.12.02.61.2-1.5-1.31.2-1.6-1.31.6-1.5
Bone volume0.91.52.41.6-0.7-1.31.3-1.0-1.41.4-0.7
Bone: connectivity density0.10.10.60.50.2-0.20.30.1-0.30.80.2
Bone: cortical apparent density0.70.92.11.51.0-0.81.10.4-1.10.30.6
Bone: cortical area0.20.30.50.2-0.7-0.40.1-0.7-0.40.3-0.7
Bone: cortical porosity3.63.96.5-2.01.32.1-2.21.62.1-2.61.6
Bone: cortical porosity2.22.43.8-1.90.31.8-2.00.71.9-1.90.7
Bone: cortical thickness0.40.62.10.61.4-0.00.10.9-0.2-0.51.1
Bone: cortical thickness0.70.82.01.21.4-0.50.60.9-0.80.01.0
Bone: cortical tissue density0.60.82.11.40.9-0.91.20.3-1.10.30.5
Bone: elastic displacement0.30.30.6-0.30.80.4-0.30.70.3-0.80.7
Bone: elastic work0.00.00.10.20.3-0.10.20.1-0.2-0.30.1
Bone: endosteal estimation3.88.118.60.9-4.3-2.11.6-3.8-1.72.4-3.9
Bone: endosteal perimeter2.04.212.1-0.1-3.5-1.00.5-2.8-0.71.7-3.0
Bone: final force0.61.01.81.3-0.3-1.21.2-0.7-1.30.7-0.6
Bone: final moment0.81.32.21.5-0.5-1.31.3-1.0-1.41.0-0.8
Bone: marrow area3.98.318.51.0-4.3-2.11.7-3.9-1.82.4-4.0
Bone: maximum diameter1.01.85.8-1.0-2.40.1-0.6-1.70.40.5-1.9
Bone: maximum force0.61.11.61.3-0.6-1.21.1-1.0-1.30.8-0.8
Bone: maximum moment0.91.62.21.5-0.9-1.41.3-1.3-1.51.2-1.1
Bone: minimum diameter1.63.07.50.3-2.7-1.10.7-2.3-0.91.6-2.5
Bone: periosteal estimation2.04.29.20.8-3.0-1.51.1-2.8-1.31.7-2.8
Bone: periosteal perimeter1.42.36.30.1-2.5-0.80.4-2.1-0.61.2-2.2
Bone: post-yield work1.82.45.30.6-2.3-1.10.8-2.0-1.01.8-2.0
Bone: stiffness0.10.20.60.80.3-0.50.5-0.0-0.60.20.0
Bone: tissue strength0.00.00.10.30.2-0.10.2-0.0-0.20.10.0
Bone: trabecular number0.40.72.10.31.50.4-0.21.20.2-0.31.3
Bone: trabecular spacing0.20.30.6-0.6-0.80.2-0.3-0.60.4-0.5-0.6
Bone: trabecular thickness0.20.30.60.80.6-0.40.50.4-0.60.50.5
Bone: trabecular tissue density0.00.00.10.1-0.2-0.10.0-0.20.1-0.3-0.1
Breakpoint value in progressive ratio session3.03.33.9-1.91.71.7-1.82.01.8-1.81.8
Distance traveled before self-admin0.90.92.00.0-1.4-0.60.2-1.1-0.51.3-1.3
Distance traveled after self-admin1.01.12.80.2-1.7-0.80.5-1.3-0.71.0-1.5
Delta time in closed arm before/after self-admin0.50.50.60.6-0.6-0.70.6-0.7-0.70.8-0.6
Delta time in open arm before/after self-admin0.00.00.1-0.2-0.40.1-0.1-0.20.10.1-0.2
Diff in mean of infusions in LGA sessions2.02.33.0-1.31.61.6-1.51.71.5-1.21.5
Extinction: sum of active levers before priming3.93.95.2-1.62.12.0-1.82.31.9-2.02.1
Active lever presses in extinction session 60.50.51.50.01.2-0.2-0.31.0-0.3-0.30.9
Delta distance traveled before/after self-admin0.20.20.50.6-0.4-0.50.7-0.4-0.5-0.0-0.3
Delta ambulatory time before/after self-admin0.10.10.20.0-0.4-0.20.2-0.3-0.2-0.1-0.3
Time in closed arm before self-admin0.20.20.70.10.8-0.0-0.00.6-0.1-0.30.6
Time in closed arm after self-admin0.20.20.50.70.7-0.50.40.3-0.5-0.10.4
Time in open arm before self-admin0.10.10.2-0.5-0.40.2-0.3-0.20.4-0.2-0.2
Time in open arm after self-admin0.50.61.4-1.2-0.40.9-0.90.10.9-0.70.1
Sum of active levers in priming session hrs 5-60.20.20.4-0.60.30.4-0.60.50.3-0.50.4
Time to tail flick, vehicle, before self-admin0.50.51.0-0.3-1.0-0.50.0-0.8-0.50.9-1.0
Time to tail flick, vehicle, after self-admin0.10.10.30.1-0.4-0.3-0.3-0.3-0.40.6-0.5
Time to tail flick, test, before self-admin0.20.20.40.50.4-0.60.50.1-0.70.20.2
Time to tail flick, test, after self-admin1.21.32.80.2-1.7-0.80.7-1.4-0.61.2-1.5
Delta time to tail flick, vehicle, before/after SA0.30.30.50.10.70.4-0.50.70.3-0.60.7
Delta time to tail flick, test, before/after SA0.40.40.70.5-0.7-0.50.5-0.6-0.40.9-0.7
Ambulatory time before self-admin0.10.10.3-0.4-0.50.2-0.3-0.30.10.3-0.5
Ambulatory time after self-admin0.40.41.5-0.4-1.2-0.3-0.2-0.8-0.20.5-1.0
Total heroin consumption1.72.13.8-1.90.41.7-1.70.81.9-1.40.6
Area under the delay curve0.30.30.8-0.40.50.5-0.60.30.3-0.90.4
Delay disc. indifference point, 0s delay0.20.20.50.1-0.5-0.40.3-0.7-0.20.3-0.7
Delay disc. indifference point, 16s delay3.03.04.9-1.02.01.6-1.51.81.4-2.22.0
Delay disc. indifference point, 2s delay0.20.30.6-0.1-0.7-0.40.1-0.8-0.50.1-0.7
Delay disc. indifference point, 24s delay0.30.30.8-0.20.60.4-0.40.40.2-0.90.7
Delay disc. indifference point, 4s delay1.41.52.21.0-1.2-1.31.1-1.5-1.30.9-1.3
Delay disc. indifference point, 8s delay0.40.40.7-0.70.50.7-0.80.50.5-0.80.6
Delay discount exponential model param0.30.30.90.4-0.5-0.50.5-0.3-0.30.9-0.5
Delay discount hyperbolic model param0.10.10.50.3-0.2-0.30.4-0.1-0.10.7-0.2
Fecal boli incidents, locomotor time 10.20.20.40.6-0.1-0.40.2-0.1-0.60.6-0.1
Change in fecal boli incidents, locomotor task0.70.71.10.7-0.6-1.00.8-0.8-1.00.8-0.8
Time >=10cm from walls, locomotor time 13.53.54.51.4-2.0-1.81.6-2.1-1.82.1-2.1
Bouts of movement, locomotor time 10.40.51.1-1.1-0.40.8-1.00.00.9-0.3-0.0
Total resting periods, locomotor time 10.20.20.4-0.5-0.70.3-0.5-0.40.40.2-0.5
Rest time, locomotor task time 13.13.44.71.3-2.2-1.71.5-2.1-1.71.9-2.1
Distance moved, locomotor task time 11.51.62.1-1.31.11.4-1.21.21.4-1.41.3
Vertical activity count, locomotor time 10.70.80.9-0.90.80.9-0.90.80.9-0.90.9
Time >=10cm from walls, locomotor time 22.93.13.91.5-1.8-1.81.4-1.9-1.72.0-1.8
Bouts of movement, locomotor time 20.60.62.1-0.3-1.4-0.3-0.0-1.10.00.4-1.1
Total resting periods, locomotor time 20.80.82.8-0.6-1.7-0.1-0.2-1.20.20.3-1.3
Rest time, locomotor task time 22.02.45.60.2-2.4-0.90.8-1.9-0.71.7-2.2
Distance moved, locomotor task time 20.30.41.20.71.1-0.10.50.6-0.3-0.20.9
Vertical activity count, locomotor time 20.10.10.20.50.5-0.30.30.2-0.30.10.4
Weight adjusted by age1.41.62.90.9-1.6-0.71.2-1.7-0.70.9-1.6
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.3-0.30.2-0.2-0.20.3-0.4-0.3
Locomotion in novel chamber0.40.41.1-1.00.30.6-0.90.40.5-0.80.4
Locomotion in novel chamber post-restriction0.60.71.20.7-0.6-1.10.6-0.8-1.10.9-0.7
Progressive ratio1.21.42.11.3-0.7-1.41.4-1.0-1.40.9-1.0
Food seeking constrained by brief footshock0.00.00.10.30.1-0.10.10.10.10.00.2
Seeking ratio, punishment vs. effort1.31.62.7-1.30.81.5-1.41.11.6-1.01.2
Run reversals in cocaine runway, females1.31.31.7-0.71.31.3-0.81.31.1-1.31.3
Run reversals in cocaine runway, males3.33.27.00.5-2.7-1.20.9-2.3-1.11.7-2.5
Latency to leave start box in cocaine runway0.20.20.60.80.1-0.50.6-0.1-0.50.3-0.1
Latency to leave start box in cocaine runway, F0.10.10.2-0.30.00.4-0.30.10.5-0.10.1
Latency to leave start box in cocaine runway, M1.51.53.51.90.3-1.51.5-0.4-1.60.8-0.2
Cd content in liver2.83.14.92.2-0.6-2.12.0-1.3-2.22.0-1.0
Co content in liver0.40.51.10.91.0-0.60.60.5-0.7-0.10.8
Cu content in liver3.94.79.2-0.93.01.7-1.52.81.3-2.03.0
Fe content in liver1.51.83.11.8-0.4-1.61.7-0.8-1.81.3-0.7
K content in liver2.52.53.6-1.81.11.8-1.71.41.9-1.71.3
Mg content in liver2.32.44.6-2.10.02.0-1.90.72.1-1.40.5
Mn content in liver1.21.43.9-1.6-2.00.7-0.8-1.10.90.0-1.4
Na content in liver2.52.73.6-1.71.11.9-1.81.41.9-1.81.3
Rb content in liver0.20.20.60.10.80.2-0.20.70.2-0.20.8
Se content in liver1.72.15.0-2.2-1.41.4-1.7-0.61.7-1.0-0.8
Sr content in liver2.11.92.41.3-1.2-1.51.3-1.4-1.41.6-1.5
Zn content in liver0.00.00.2-0.20.00.1-0.40.10.20.10.1