Hub : Genes

Celsr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000053889 0.02 0.02 9.9e-03 0 -0 -0 -0 3.6e-01 1.0e+00 8.8e-01 7.6e-01
2 Brain gene expression ENSRNOG00000053889 0.08 0.06 7.0e-06 0.06 0.05 0.06 0.06 1.3e-06 1.0e-05 3.6e-06 3.7e-06
3 Brain intron excision ratio chr8:109542778:109542875 0.02 0.02 7.4e-03 0.01 0.01 0.01 0.01 5.0e-02 3.7e-02 3.4e-02 5.5e-02
4 Brain intron excision ratio chr8:109542778:109543072 0.03 0.02 4.3e-03 0.02 0.01 0.01 0.01 9.2e-03 7.2e-02 5.0e-02 5.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.41.32.01.4-0.81.3-0.8
BMI without tail1.53.24.21.9-1.62.0-1.6
Body weight6.025.229.55.4-5.04.7-5.0
Epididymis fat weight0.20.40.40.6-0.60.5-0.6
Glucose0.40.50.80.8-0.60.9-0.6
Heart weight2.53.64.02.0-2.01.5-2.0
Left kidney weight1.02.94.11.9-1.42.0-1.4
Right kidney weight0.30.81.41.0-0.61.2-0.6
Tail length6.318.919.54.4-4.44.2-4.4
Length with tail8.832.134.45.9-5.85.2-5.8
Length without tail6.413.915.53.9-3.93.2-3.9
Liver weight, left0.10.10.30.1-0.30.6-0.3
Liver weight, right1.42.32.91.6-1.41.7-1.4
Parametrial fat weight1.32.52.81.6-1.51.7-1.5
Retroperitoneal fat weight0.62.12.21.4-1.41.5-1.4
Intraocular pressure0.81.21.50.9-1.21.0-1.2
Extensor digitorum longus weight0.20.81.0-0.80.9-1.00.9
Soleus weight3.510.311.83.4-3.23.0-3.2
Tibialis anterior weight0.00.00.00.2-0.0-0.1-0.0
Tibia length6.618.522.04.7-4.24.1-4.2
Number of licking bursts0.40.40.8-0.60.5-0.90.5
Food consumed during 24 hour testing period1.51.92.11.4-1.41.3-1.4
Times rat made contact with spout0.70.80.90.9-1.00.7-1.0
Mean time between licks in bursts1.31.81.8-1.31.3-1.31.3
Mean num. licks in bursts1.21.41.91.2-1.11.4-1.1
Std. dev. time between licks in bursts5.66.78.0-2.52.5-2.82.5
Water consumed over 24 hours0.00.00.10.1-0.0-0.3-0.0
Indifference point 0 sec1.82.93.71.5-1.71.9-1.7
Indifference point AUC0.00.00.20.2-0.00.4-0.0
Indifference point function ln k0.10.20.2-0.20.5-0.30.5
Indifference point function log k0.10.20.2-0.20.5-0.30.5
Delay discounting total patch changes 0 sec1.93.13.51.6-1.81.9-1.8
Delay discounting total patch changes 12 sec1.31.81.91.2-1.41.3-1.4
Delay discounting total patch changes 18 sec2.53.33.71.6-1.91.9-1.9
Delay discounting total patch changes 24 sec3.64.54.92.1-2.22.0-2.2
Delay discounting total patch changes 6 sec0.40.61.10.5-0.71.0-0.7
Delay discounting time to switch 0 sec0.20.30.5-0.50.4-0.70.4
Delay discounting water rate 0 sec0.10.20.20.3-0.50.4-0.5
Delay discounting water rate 12 sec0.30.40.40.6-0.60.7-0.6
Delay discounting water rate 18 sec0.00.00.10.10.0-0.30.0
Delay discounting water rate 24 sec0.50.70.80.8-0.90.7-0.9
Delay discounting water rate 6 sec0.40.50.60.7-0.70.7-0.7
Locomotor activity5.79.09.63.1-3.02.9-3.0
Locomotor testing distance5.08.28.93.0-2.82.8-2.8
Locomotor testing rearing0.10.10.20.3-0.40.3-0.4
Light reinforcement 10.71.21.31.1-1.11.0-1.1
Light reinforcement 20.20.20.4-0.30.60.00.6
Reaction time number correct0.50.71.2-0.90.6-1.10.6
Reaction time mean minus median0.10.10.20.5-0.20.4-0.2
Reaction time mean minus median AUC0.20.30.50.7-0.40.6-0.4
Reaction time num false alarms0.30.40.5-0.70.6-0.70.6
Reaction time num false alarms AUC0.10.10.1-0.30.2-0.30.2
Reaction time trials correct on left0.50.71.2-0.90.6-1.10.6
Reaction time trials on left0.50.81.2-1.00.7-1.10.7
Reaction time mean0.00.00.0-0.0-0.10.1-0.1
Reaction time mean AUC0.00.00.0-0.1-0.00.1-0.0
Median of all reaction times0.00.00.0-0.2-0.1-0.0-0.1
Reaction time omissions0.10.20.4-0.60.2-0.50.2
Reaction time false alarm rate0.00.00.0-0.10.1-0.00.1
Reaction time premature initiation rate2.33.03.41.8-1.71.7-1.7
Reaction time premature initiations1.01.41.51.2-1.21.0-1.2
Std. dev. reaction times0.10.20.30.4-0.30.5-0.3
Reaction time trials completed0.50.81.2-1.00.7-1.10.7
Reaction time trials AUC0.71.01.5-1.10.8-1.20.8
Social response proportion1.01.11.40.8-1.20.8-1.2
Social responses0.50.70.80.8-0.90.7-0.9
Social time0.50.71.4-0.70.7-1.20.7
Conditioned locomotion2.83.33.9-2.01.9-1.61.9
Cocaine response after cond. corrected0.20.20.30.4-0.5-0.2-0.5
Cocaine response after cond. not corrected1.41.62.01.4-1.40.8-1.4
Cocaine response before conditioning1.31.62.01.4-1.11.4-1.1
Saline control response1.82.43.11.3-1.51.8-1.5
Condit. Reinf. active minus inactive responses1.82.22.61.6-1.51.4-1.5
Condit. Reinf. active-inactive response ratio1.31.31.81.3-1.21.0-1.2
Condit. Reinf. active responses1.72.42.61.6-1.61.5-1.6
Condit. Reinf. inactive responses0.00.00.0-0.0-0.10.1-0.1
Condit. Reinf. lever presses2.23.03.61.9-1.71.6-1.7
Condit. Reinf. lever reinforcers received1.92.72.91.7-1.61.6-1.6
Pavlov. Cond. lever latency0.30.40.5-0.70.5-0.60.5
Pavlov. Cond. magazine entry latency0.20.20.3-0.30.5-0.40.5
Pavlov. Cond. change in total contacts1.92.63.21.8-1.61.5-1.6
Pavlov. Cond. index score0.00.00.10.3-0.10.1-0.1
Pavlov. Cond. latency score0.00.00.10.30.00.10.0
Pavlov. Cond. lever contacts0.81.11.41.2-1.01.1-1.0
Pavlov. Cond. magazine entry number0.40.50.70.6-0.80.7-0.8
Pavlov. Cond. intertrial magazine entries0.40.50.8-0.90.6-0.70.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.3-0.00.1-0.0
Pavlov. Cond. response bias0.00.00.10.3-0.00.1-0.0
Conditioned reinforcement - actives0.40.40.5-0.70.6-0.60.6
Conditioned reinforcement - inactives1.51.72.8-1.01.3-1.71.3
Conditioned locomotion0.20.20.4-0.60.5-0.30.5
Intermittent access intake day 1-15 change0.80.81.6-0.70.7-1.30.7
Intermittent access intake escalation0.80.81.5-0.70.7-1.20.7
Intermittent access intake escalation 20.10.10.30.0-0.2-0.6-0.2
Intermitt. access day 1 inactive lever presses0.00.00.00.20.0-0.00.0
Intermitt. access day 15 inactive lever presses0.91.01.6-0.71.0-1.31.0
Intermitt. access escalation Index0.00.00.00.10.10.20.1
Intermittent access day 1 total infusions0.10.10.1-0.30.3-0.10.3
Intermittent access day 15 total infusions0.50.60.7-0.70.8-0.90.8
Intermittent access terminal intake (last 3 days)0.30.30.3-0.50.6-0.50.6
Intermittent access total infusions0.60.70.7-0.80.9-0.80.9
Intermittent access day 1 locomotion0.20.20.2-0.50.5-0.20.5
Intermittent access day 15 total locomotion0.80.81.0-0.91.0-0.71.0
Intermittent access total locomotion1.01.11.3-1.11.1-0.81.1
Intermittent access standard deviation0.10.10.10.3-0.3-0.4-0.3
Cocaine induced anxiety0.40.40.5-0.50.7-0.70.7
Post-drug Anxiety0.20.20.2-0.40.4-0.40.4
Baseline Anxiety0.40.40.6-0.80.6-0.70.6
Lifetime Intake0.50.50.6-0.70.8-0.60.8
Incentive Sensitization - Responses1.91.92.0-1.31.3-1.41.3
Incentive Sensitization - Breakpoint1.81.92.0-1.31.3-1.41.3
Progressive ratio test 1 active lever presses0.00.00.10.00.20.10.2
Progressive ratio test 1 breakpoint0.10.10.1-0.00.30.10.3
Progressive ratio test 1 inactive lever presses0.60.60.8-0.50.8-0.90.8
Progressive ratio test 2 active lever presses1.01.11.2-1.01.1-1.01.1
Progressive ratio test 2 breakpoint0.70.80.8-0.80.9-0.80.9
Progressive ratio test 2 inactive lever presses2.52.93.9-1.41.7-2.01.7
Total sessions with >9 infusions0.20.20.4-0.30.4-0.70.4
Short access day 1 total inactive lever presses5.25.86.0-2.42.4-2.42.4
Short access day 10 total inactive lever presses0.10.10.40.10.3-0.60.3
Short access day 1 total infusions1.31.41.4-1.21.2-1.21.2
Short access day 10 total infusions0.10.10.1-0.30.3-0.20.3
Short access total infusions0.60.70.8-0.90.9-0.70.9
Short access day 1 locomotion0.00.10.1-0.10.3-0.20.3
Short access day 10 total locomotion0.10.10.10.2-0.20.3-0.2
Short access total locomotion0.00.00.10.00.10.30.1
Compulsive drug intake0.00.00.1-0.30.20.10.2
One hour access (0.3 mA shock)0.30.30.4-0.70.6-0.40.6
One hour access (shock baseline)0.10.10.1-0.30.4-0.30.4
Number of responses in last shaping day1.31.31.5-1.01.2-1.21.2
Context. condit. distance diff. score0.00.00.0-0.00.0-0.00.0
Locomotion velocity, session 10.10.10.1-0.20.2-0.30.2
Locomotion distance, session 10.91.11.51.2-0.91.2-0.9
Locomotion velocity, session 20.30.30.4-0.40.6-0.60.6
Locomotion distance, session 20.00.00.10.00.30.20.3
Locomotion velocity, session 30.10.20.40.5-0.10.6-0.1
Locomotion distance, session 31.11.11.6-1.01.3-0.71.3
Stereotopy head waving bouts, day 30.00.00.10.1-0.2-0.2-0.2
Stereotopy head waving duration, day 30.20.20.30.4-0.60.2-0.6
Locomotion velocity, session 70.10.10.40.2-0.20.6-0.2
Locomotion distance, session 70.91.11.4-1.11.2-0.71.2
Stereotopy head waving bouts, day 70.00.00.0-0.10.10.10.1
Stereotopy head waving duration, day 70.40.40.50.7-0.60.7-0.6
Locomotion velocity, session 80.20.30.50.6-0.30.7-0.3
Locomotion distance, session 80.30.40.90.7-0.30.9-0.3
Degree of sensitization distance1.11.11.40.9-1.20.9-1.2
Degree of sensitization stereotypy0.10.10.20.3-0.30.5-0.3
Condit. Reinf. active minus inactive responses0.10.10.10.2-0.4-0.1-0.4
Condit. Reinf. active-inactive response ratio0.20.20.30.3-0.6-0.1-0.6
Condit. Reinf. active responses0.00.00.1-0.20.1-0.30.1
Condit. Reinf. inactive responses0.50.60.8-0.70.9-0.50.9
Incentive salience index mean0.10.10.2-0.30.2-0.40.2
Condit. Reinf. lever presses1.41.92.1-1.31.4-1.31.4
Time in familiar zone, hab. session 11.81.72.1-1.41.1-1.41.1
Time in novel zone, hab. session 10.90.81.01.0-0.90.9-0.9
Total zone transitions, hab. session 10.60.81.21.0-0.71.1-0.7
Total locomotion distance, hab. session 10.30.40.50.7-0.50.7-0.5
Locomotion velocity, hab. session 10.30.50.70.8-0.50.8-0.5
Time in familiar zone, hab. session 20.90.91.4-0.90.8-1.20.8
Time in novel zone, hab. session 20.10.10.20.2-0.30.4-0.3
Total zone transitions, hab. session 20.00.10.20.4-0.00.3-0.0
Total locomotion distance, hab. session 20.30.40.60.8-0.50.8-0.5
Locomotion velocity, hab. session 20.20.30.50.7-0.40.7-0.4
Novel to familiar place preference ratio1.11.22.50.9-0.91.6-0.9
Novelty place preference1.21.22.60.9-0.91.6-0.9
Time in novel zone, NPP test1.41.52.81.0-1.01.7-1.0
Total zone transitions, NPP test2.33.34.52.1-1.52.1-1.5
Total locomotion distance, NPP test1.11.52.01.4-1.11.4-1.1
Locomotion velocity, NPP test1.21.72.21.5-1.11.5-1.1
Pavlov. Cond. lever latency5.36.77.22.5-2.72.5-2.7
Pavlov. Cond. magazine entry latency6.88.79.1-2.92.9-3.02.9
Pavlov. Cond. change in total contacts1.82.02.3-1.41.3-1.51.3
Pavlov. Cond. index score6.68.48.6-2.82.9-2.92.9
Pavlov. Cond. latency score6.48.28.4-2.82.9-2.92.9
Pavlov. Cond. lever contacts2.93.43.7-1.71.9-1.81.9
Pavlov. Cond. magazine entry number7.69.59.63.1-3.13.1-3.1
Pavlov. Cond. intertrial magazine entries0.30.30.40.6-0.60.6-0.6
Pavlov. Cond. lever-magazine prob. diff.6.07.58.0-2.72.7-2.82.7
Pavlov. Cond. response bias7.18.79.1-2.93.0-3.03.0
Bone: apparent density0.00.10.20.2-0.10.5-0.1
Bone surface0.10.10.2-0.20.4-0.20.4
Bone volume0.00.00.00.00.2-0.00.2
Bone: connectivity density0.10.20.2-0.50.40.00.4
Bone: cortical apparent density0.20.20.3-0.50.4-0.40.4
Bone: cortical area0.30.51.1-0.50.5-1.10.5
Bone: cortical porosity0.00.00.1-0.30.10.20.1
Bone: cortical porosity0.10.10.3-0.60.3-0.00.3
Bone: cortical thickness0.10.10.10.3-0.3-0.3-0.3
Bone: cortical thickness0.00.00.0-0.00.1-0.20.1
Bone: cortical tissue density0.20.20.3-0.50.4-0.40.4
Bone: elastic displacement0.00.00.10.2-0.3-0.0-0.3
Bone: elastic work0.30.40.70.8-0.60.4-0.6
Bone: endosteal estimation0.00.10.10.1-0.20.4-0.2
Bone: endosteal perimeter1.12.32.3-1.51.5-1.51.5
Bone: final force0.71.21.51.2-1.10.8-1.1
Bone: final moment0.91.51.91.4-1.30.9-1.3
Bone: marrow area0.00.10.20.2-0.30.4-0.3
Bone: maximum diameter0.50.91.5-0.80.8-1.20.8
Bone: maximum force0.61.01.11.0-1.00.8-1.0
Bone: maximum moment0.61.11.31.1-1.10.8-1.1
Bone: minimum diameter0.51.01.2-0.91.0-1.11.0
Bone: periosteal estimation0.00.00.0-0.00.0-0.20.0
Bone: periosteal perimeter1.32.22.6-1.41.4-1.61.4
Bone: post-yield work0.00.00.10.2-0.10.3-0.1
Bone: stiffness0.10.20.20.4-0.40.4-0.4
Bone: tissue strength2.42.32.61.6-1.61.2-1.6
Bone: trabecular number0.50.81.0-0.91.0-0.51.0
Bone: trabecular spacing1.11.41.71.2-1.30.8-1.3
Bone: trabecular thickness0.10.10.20.3-0.10.5-0.1
Bone: trabecular tissue density0.30.40.50.6-0.60.7-0.6
Breakpoint value in progressive ratio session0.10.10.30.3-0.30.5-0.3
Distance traveled before self-admin0.10.10.4-0.20.0-0.60.0
Distance traveled after self-admin0.50.50.8-0.70.6-0.90.6
Delta time in closed arm before/after self-admin0.10.10.1-0.30.3-0.20.3
Delta time in open arm before/after self-admin0.10.10.20.3-0.30.4-0.3
Diff in mean of infusions in LGA sessions0.00.00.10.00.1-0.30.1
Extinction: sum of active levers before priming0.00.00.1-0.00.00.30.0
Active lever presses in extinction session 60.40.40.60.6-0.60.8-0.6
Delta distance traveled before/after self-admin0.20.20.2-0.40.5-0.20.5
Delta ambulatory time before/after self-admin0.20.20.40.4-0.30.6-0.3
Time in closed arm before self-admin1.51.72.21.5-1.31.2-1.3
Time in closed arm after self-admin0.00.00.10.2-0.20.0-0.2
Time in open arm before self-admin1.01.11.4-1.21.0-1.01.0
Time in open arm after self-admin0.20.20.4-0.60.5-0.00.5
Sum of active levers in priming session hrs 5-60.70.70.90.7-0.81.0-0.8
Time to tail flick, vehicle, before self-admin2.32.32.41.5-1.51.5-1.5
Time to tail flick, vehicle, after self-admin0.60.70.80.9-0.90.5-0.9
Time to tail flick, test, before self-admin0.30.30.70.5-0.40.9-0.4
Time to tail flick, test, after self-admin0.10.10.1-0.30.2-0.30.2
Delta time to tail flick, vehicle, before/after SA0.70.61.1-0.70.7-1.00.7
Delta time to tail flick, test, before/after SA0.60.50.6-0.70.7-0.80.7
Ambulatory time before self-admin0.20.30.5-0.50.3-0.70.3
Ambulatory time after self-admin0.10.10.2-0.30.3-0.40.3
Total heroin consumption0.80.91.11.0-1.00.8-1.0
Area under the delay curve1.92.02.4-1.41.5-1.11.5
Delay disc. indifference point, 0s delay0.00.00.0-0.10.10.00.1
Delay disc. indifference point, 16s delay0.80.91.0-0.91.0-0.71.0
Delay disc. indifference point, 2s delay0.20.30.3-0.50.6-0.50.6
Delay disc. indifference point, 24s delay0.80.80.9-0.90.9-0.70.9
Delay disc. indifference point, 4s delay2.02.12.4-1.41.6-1.31.6
Delay disc. indifference point, 8s delay2.02.02.3-1.41.5-1.21.5
Delay discount exponential model param2.32.42.81.5-1.71.3-1.7
Delay discount hyperbolic model param2.22.42.81.5-1.71.3-1.7
Fecal boli incidents, locomotor time 10.40.40.50.7-0.60.6-0.6
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.10.2-0.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.40.3-0.10.3
Bouts of movement, locomotor time 10.00.00.10.3-0.10.2-0.1
Total resting periods, locomotor time 10.00.00.10.2-0.10.2-0.1
Rest time, locomotor task time 10.50.60.7-0.80.8-0.60.8
Distance moved, locomotor task time 11.61.72.11.3-1.41.0-1.4
Vertical activity count, locomotor time 10.91.01.11.0-1.00.8-1.0
Time >=10cm from walls, locomotor time 21.51.61.81.2-1.31.2-1.3
Bouts of movement, locomotor time 20.10.10.3-0.30.2-0.50.2
Total resting periods, locomotor time 20.30.30.5-0.60.5-0.70.5
Rest time, locomotor task time 20.10.10.1-0.40.4-0.10.4
Distance moved, locomotor task time 21.21.41.81.3-1.30.8-1.3
Vertical activity count, locomotor time 20.10.10.20.4-0.40.1-0.4
Weight adjusted by age0.10.20.20.4-0.50.1-0.5
Seeking ratio, delayed vs. immediate footshock2.52.83.3-1.81.8-1.31.8
Locomotion in novel chamber0.10.10.2-0.10.2-0.50.2
Locomotion in novel chamber post-restriction0.91.01.11.0-1.01.1-1.0
Progressive ratio4.04.64.82.1-2.22.0-2.2
Food seeking constrained by brief footshock0.50.61.0-0.70.7-1.00.7
Seeking ratio, punishment vs. effort5.46.76.8-2.52.6-2.62.6
Run reversals in cocaine runway, females1.61.62.0-1.21.2-1.41.2
Run reversals in cocaine runway, males0.80.70.90.9-0.90.6-0.9
Latency to leave start box in cocaine runway0.50.50.50.7-0.70.7-0.7
Latency to leave start box in cocaine runway, F1.21.41.61.3-1.30.8-1.3
Latency to leave start box in cocaine runway, M0.30.30.4-0.60.6-0.20.6
Cd content in liver2.22.43.21.4-1.81.2-1.8
Co content in liver0.00.10.1-0.20.1-0.40.1
Cu content in liver4.14.95.52.1-2.22.3-2.2
Fe content in liver1.82.12.81.2-1.71.1-1.7
K content in liver0.90.91.51.0-0.81.2-0.8
Mg content in liver0.00.00.10.20.20.30.2
Mn content in liver0.60.71.01.0-0.61.0-0.6
Na content in liver0.40.50.60.5-0.70.7-0.7
Rb content in liver0.81.01.60.6-1.30.6-1.3
Se content in liver0.10.10.20.4-0.20.4-0.2
Sr content in liver0.00.00.10.30.10.20.1
Zn content in liver4.75.25.52.3-2.22.4-2.2