Intermittent access total infusions

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166093700	167491708	1	1	9.07e-13	2.04e-04	3.85e-09	Tead1
2	chr8	33211184	34601262	1	1	1.11e-07	2.05e-01	1.50e-08	Ddx25

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	1.98	2	0	0	1e+00	Ddx25 Tead1
BMI without tail	4.08	1	0	0	1e+00	Ddx25
Right kidney weight	2.2	1	0	0	1e+00	Ddx25
Tail length	6.06	1	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	1e+00	Ddx25
Parametrial fat weight	2.79	1	0	0	1e+00	Ddx25
Tibialis anterior weight	1.5	1	0	0	1e+00	Tead1
Patch foraging indifference point 0 sec	10.57	1	0	0	1e+00	Tead1
Patch foraging total patch changes 0 sec	9.14	1	0	0	1e+00	Tead1
Patch foraging total patch changes 12 sec	9.53	1	0	0	1e+00	Tead1
Patch foraging total patch changes 18 sec	4.38	1	0	0	1e+00	Tead1
Patch foraging total patch changes 6 sec	6.76	1	0	0	1e+00	Tead1
Patch foraging time to switch 0 sec	6.02	1	0	0	1e+00	Tead1
Patch foraging water rate 24 sec	8.95	1	0	0	1e+00	Tead1
Locomotor activity	4.49	1	0	0	1e+00	Ddx25
Locomotor testing distance	4.75	1	0	0	1e+00	Ddx25
Locomotor testing rearing	3.33	1	0	0	1e+00	Ddx25
Reaction time mean minus median AUC	3.91	1	0	0	1e+00	Ddx25
Reaction time mean	4.52	2	0	0	1e+00	Ddx25 Tead1
Reaction time mean AUC	3.97	1	0	0	1e+00	Tead1
Median of all reaction times	4.38	1	0	0	1e+00	Tead1
Conditioned reinforcement - inactives	12.53	2	0	0	1e+00	Ddx25 Tead1
Intermittent access intake day 1-15 change	43.02	2	1	50	1e+00	Ddx25 Tead1
Intermittent access intake escalation	41.26	1	1	50	1e+00	Ddx25
Intermittent access intake escalation 2	20.4	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access day 1 inactive lever presses	17.35	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access day 15 inactive lever presses	25.67	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access escalation Index	14.59	1	0	0	1e+00	Ddx25
Intermittent access day 1 total infusions	56.33	1	1	50	1e+00	Tead1
Intermittent access day 15 total infusions	26.19	2	1	50	1e+00	Ddx25 Tead1
Intermittent access terminal intake (last 3 days)	24.5	2	1	50	1e+00	Ddx25 Tead1
Intermittent access day 1 locomotion	11.44	1	0	0	1e+00	Tead1
Intermittent access total locomotion	7.22	1	0	0	1e+00	Tead1
Intermittent access standard deviation	15.63	2	0	0	1e+00	Ddx25 Tead1
Cocaine induced anxiety	12.68	1	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	1e+00	Ddx25
Lifetime Intake	43.6	2	2	100	1e+00	Ddx25 Tead1
Incentive Sensitization - Responses	27.36	2	1	50	1e+00	Ddx25 Tead1
Incentive Sensitization - Breakpoint	27.9	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 1 active lever presses	17.35	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 1 breakpoint	15.45	2	0	0	1e+00	Ddx25 Tead1
Progressive ratio test 1 inactive lever presses	10.24	2	0	0	1e+00	Ddx25 Tead1
Progressive ratio test 2 active lever presses	30.08	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 2 breakpoint	31.55	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 2 inactive lever presses	22.46	2	1	50	1e+00	Ddx25 Tead1
Total sessions with >9 infusions	21.06	2	0	0	1e+00	Ddx25 Tead1
Short access day 10 total inactive lever presses	13.19	1	0	0	1e+00	Tead1
Short access day 1 total infusions	31.31	2	1	50	1e+00	Ddx25 Tead1
Short access day 10 total infusions	68.19	2	2	100	1e+00	Ddx25 Tead1
Short access total infusions	54.83	2	2	100	1e+00	Ddx25 Tead1
Short access day 1 locomotion	10.43	1	0	0	1e+00	Tead1
Short access day 10 total locomotion	8.02	2	0	0	1e+00	Ddx25 Tead1
Short access total locomotion	27.61	1	1	50	1e+00	Tead1
Compulsive drug intake	22.25	1	0	0	1e+00	Tead1
One hour access (0.3 mA shock)	70.35	1	1	50	1e+00	Ddx25
One hour access (shock baseline)	22.46	2	1	50	1e+00	Ddx25 Tead1
Number of responses in last shaping day	22.92	2	1	50	1e+00	Ddx25 Tead1
Bone: cortical area	7.52	1	0	0	1e+00	Ddx25
Bone: cortical porosity	5.3	1	0	0	1e+00	Tead1
Bone: cortical porosity	7.17	1	0	0	1e+00	Tead1
Bone: cortical thickness	4.39	1	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	1e+00	Ddx25
Bone: trabecular thickness	4.3	1	0	0	1e+00	Ddx25
Breakpoint value in progressive ratio session	11.08	1	0	0	1e+00	Tead1
Distance traveled before self-admin	12.14	2	0	0	1e+00	Ddx25 Tead1
Distance traveled after self-admin	11.88	2	0	0	1e+00	Ddx25 Tead1
Delta time in closed arm before/after self-admin	6.42	1	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	23.79	1	0	0	1e+00	Ddx25
Active lever presses in extinction session 6	9.49	1	0	0	1e+00	Ddx25
Delta distance traveled before/after self-admin	6.76	1	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	14.46	1	0	0	1e+00	Ddx25
Time in closed arm before self-admin	11.48	1	0	0	1e+00	Tead1
Time in closed arm after self-admin	8.36	1	0	0	1e+00	Tead1
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	1e+00	Ddx25
Time to tail flick, test, before self-admin	5.88	1	0	0	1e+00	Ddx25
Delta time to tail flick, vehicle, before/after SA	5.9	1	0	0	1e+00	Tead1
Ambulatory time before self-admin	18.9	2	1	50	1e+00	Ddx25 Tead1
Ambulatory time after self-admin	12.41	2	0	0	1e+00	Ddx25 Tead1
Total heroin consumption	7.85	2	0	0	1e+00	Ddx25 Tead1
Seeking ratio, delayed vs. immediate footshock	5.2	1	0	0	1e+00	Tead1
Run reversals in cocaine runway, males	8.37	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	10.76	1	0	0	1e+00	Ddx25
Sr content in liver	9.74	1	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.07
Adipose	alternative TSS	0	1.08
Adipose	gene expression	1	1.11
Adipose	isoform ratio	0	1.12
Adipose	intron excision ratio	0	1.09
Adipose	mRNA stability	0	1.12
BLA	alternative polyA	0	1.09
BLA	alternative TSS	0	1.1
BLA	gene expression	0	1.11
BLA	isoform ratio	0	1.07
BLA	intron excision ratio	0	1.05
BLA	mRNA stability	0	1.15
Brain	alternative polyA	0	1.08
Brain	alternative TSS	0	1.08
Brain	gene expression	0	1.12
Brain	isoform ratio	0	1.12
Brain	intron excision ratio	0	1.12
Brain	mRNA stability	0	1.14
Eye	alternative polyA	0	1.06
Eye	alternative TSS	0	1.05
Eye	gene expression	0	1.18
Eye	isoform ratio	0	1.1
Eye	intron excision ratio	0	1.01
Eye	mRNA stability	0	1.18
IL	alternative polyA	0	1.09
IL	alternative TSS	0	1.1
IL	gene expression	0	1.13
IL	isoform ratio	0	1.11
IL	intron excision ratio	0	1.09
IL	mRNA stability	0	1.21
LHb	alternative polyA	0	1.01
LHb	alternative TSS	0	1.36
LHb	gene expression	0	1.13
LHb	isoform ratio	0	1.2
LHb	intron excision ratio	0	1.02
LHb	mRNA stability	0	1.19
Liver	alternative polyA	0	1.13
Liver	alternative TSS	0	1.16
Liver	gene expression	0	1.11
Liver	isoform ratio	0	1.17
Liver	intron excision ratio	0	1.17
Liver	mRNA stability	0	1.13
NAcc	alternative polyA	0	1.07
NAcc	alternative TSS	1	1.05
NAcc	gene expression	0	1.13
NAcc	isoform ratio	0	1.09
NAcc	intron excision ratio	0	1.09
NAcc	mRNA stability	0	1.14
OFC	alternative polyA	0	1.15
OFC	alternative TSS	0	1.14
OFC	gene expression	0	1.1
OFC	isoform ratio	0	1.13
OFC	intron excision ratio	0	1.02
OFC	mRNA stability	0	1.13
PL	alternative polyA	0	1.09
PL	alternative TSS	0	1.07
PL	gene expression	0	1.12
PL	isoform ratio	0	1.15
PL	intron excision ratio	0	1.1
PL	mRNA stability	0	1.15
pVTA	alternative polyA	0	1.14
pVTA	alternative TSS	0	1.1
pVTA	gene expression	0	1.14
pVTA	isoform ratio	0	1.13
pVTA	intron excision ratio	0	1.09
pVTA	mRNA stability	0	1.22
RMTg	alternative polyA	0	1.1
RMTg	alternative TSS	0	1.03
RMTg	gene expression	0	1.14
RMTg	isoform ratio	0	1.04
RMTg	intron excision ratio	0	1.15
RMTg	mRNA stability	0	1.31