Sum of active levers in priming session hrs 5-6

Sum of active levers during the 5th and 6th hour of the priming session

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr4 10085840 10964652 1 1 4.97e-09 1.68e-01 1e+00 Abcb8

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 2.61 1 0 0 0 1e+00 Abcb8
BMI without tail 2.45 1 0 0 0 1e+00 Abcb8
Right kidney weight 1.88 1 0 0 0 1e+00 Abcb8
Length with tail 1.06 1 0 0 0 1e+00 Abcb8
Length without tail 2.32 1 0 0 0 1e+00 Abcb8
Food consumed during 24 hour testing period 4.57 1 0 0 0 1e+00 Abcb8
Patch foraging indifference point 0 sec 6.28 1 0 0 0 1e+00 Abcb8
Patch foraging total patch changes 0 sec 6.05 1 0 0 0 1e+00 Abcb8
Patch foraging total patch changes 6 sec 5.19 1 0 0 0 1e+00 Abcb8
Patch foraging water rate 12 sec 7.82 1 0 0 0 1e+00 Abcb8
Light reinforcement 1 2.63 1 0 0 0 1e+00 Abcb8
Light reinforcement 2 2.91 1 0 0 0 1e+00 Abcb8
Reaction time num false alarms 4.36 1 0 0 0 1e+00 Abcb8
Reaction time num false alarms AUC 3.62 1 0 0 0 1e+00 Abcb8
Reaction time omissions 13.34 1 0 0 0 1e+00 Abcb8
Reaction time premature initiations 5.75 1 0 0 0 1e+00 Abcb8
Cocaine response after cond. corrected 4.68 1 0 0 0 1e+00 Abcb8
Conditioned reinforcement - actives 10.78 1 0 0 0 1e+00 Abcb8
Intermittent access intake escalation 2 20.96 1 0 0 0 1e+00 Abcb8
Intermittent access day 1 total infusions 3.32 1 0 0 0 1e+00 Abcb8
Intermittent access total infusions 3.9 1 0 0 0 1e+00 Abcb8
Intermittent access total locomotion 4.67 1 0 0 0 1e+00 Abcb8
Cocaine induced anxiety 7.96 1 0 0 0 1e+00 Abcb8
Baseline Anxiety 11.67 1 0 0 0 1e+00 Abcb8
Incentive Sensitization - Responses 11.93 1 0 0 0 1e+00 Abcb8
Incentive Sensitization - Breakpoint 11.74 1 0 0 0 1e+00 Abcb8
Progressive ratio test 1 breakpoint 4.28 1 0 0 0 1e+00 Abcb8
Progressive ratio test 2 active lever presses 4.65 1 0 0 0 1e+00 Abcb8
Progressive ratio test 2 breakpoint 4.28 1 0 0 0 1e+00 Abcb8
Progressive ratio test 2 inactive lever presses 3.83 1 0 0 0 1e+00 Abcb8
Short access day 1 total inactive lever presses 23.74 1 0 0 0 1e+00 Abcb8
Short access day 10 total inactive lever presses 4.68 1 0 0 0 1e+00 Abcb8
Short access day 1 total infusions 3.98 1 0 0 0 1e+00 Abcb8
Short access day 10 total infusions 8.23 1 0 0 0 1e+00 Abcb8
Short access day 1 locomotion 14.94 1 0 0 0 1e+00 Abcb8
Short access day 10 total locomotion 6.24 1 0 0 0 1e+00 Abcb8
Compulsive drug intake 14.15 1 0 0 0 1e+00 Abcb8
Number of responses in last shaping day 11.75 1 0 0 0 1e+00 Abcb8
Locomotion velocity, session 2 3.69 1 0 0 0 1e+00 Abcb8
Locomotion distance, session 3 3.9 1 0 0 0 1e+00 Abcb8
Stereotopy head waving duration, day 7 4.21 1 0 0 0 1e+00 Abcb8
Locomotion distance, session 8 2.98 1 0 0 0 1e+00 Abcb8
Condit. Reinf. active minus inactive responses 16.72 1 0 0 0 1e+00 Abcb8
Condit. Reinf. active-inactive response ratio 8.58 1 0 0 0 1e+00 Abcb8
Condit. Reinf. active responses 16.06 1 0 0 0 1e+00 Abcb8
Incentive salience index mean 13.29 1 0 0 0 1e+00 Abcb8
Condit. Reinf. lever presses 4.61 1 0 0 0 1e+00 Abcb8
Time in novel zone, hab. session 1 8.85 1 0 0 0 1e+00 Abcb8
Total locomotion distance, NPP test 3.02 1 0 0 0 1e+00 Abcb8
Locomotion velocity, NPP test 2.92 1 0 0 0 1e+00 Abcb8
Pavlov. Cond. intertrial magazine entries 5.02 1 0 0 0 1e+00 Abcb8
Bone: apparent density 4.12 1 0 0 0 1e+00 Abcb8
Bone surface 2.76 1 0 0 0 1e+00 Abcb8
Bone volume 3.86 1 0 0 0 1e+00 Abcb8
Bone: connectivity density 3.27 1 0 0 0 1e+00 Abcb8
Bone: cortical area 6.9 1 0 0 0 1e+00 Abcb8
Bone: cortical thickness 4.69 1 0 0 0 1e+00 Abcb8
Bone: maximum diameter 3.67 1 0 0 0 1e+00 Abcb8
Bone: periosteal estimation 1.87 1 0 0 0 1e+00 Abcb8
Bone: periosteal perimeter 3.51 1 0 0 0 1e+00 Abcb8
Bone: post-yield work 2.92 1 0 0 0 1e+00 Abcb8
Bone: trabecular number 6.09 1 0 0 0 1e+00 Abcb8
Bone: trabecular thickness 5.88 1 0 0 0 1e+00 Abcb8
Distance traveled before self-admin 12.24 1 0 0 0 1e+00 Abcb8
Distance traveled after self-admin 11.43 1 0 0 0 1e+00 Abcb8
Delta time in open arm before/after self-admin 9.79 1 0 0 0 1e+00 Abcb8
Extinction: sum of active levers before priming 56.63 1 1 100 0 1e+00 Abcb8
Active lever presses in extinction session 6 6.45 1 0 0 0 1e+00 Abcb8
Delta distance traveled before/after self-admin 6.32 1 0 0 0 1e+00 Abcb8
Delta ambulatory time before/after self-admin 4.98 1 0 0 0 1e+00 Abcb8
Time in closed arm before self-admin 12.74 1 0 0 0 1e+00 Abcb8
Time in closed arm after self-admin 34.42 1 1 100 0 1e+00 Abcb8
Time in open arm after self-admin 24.75 1 1 100 0 1e+00 Abcb8
Time to tail flick, vehicle, before self-admin 16.02 1 0 0 0 1e+00 Abcb8
Time to tail flick, vehicle, after self-admin 8.93 1 0 0 0 1e+00 Abcb8
Time to tail flick, test, after self-admin 13.81 1 0 0 0 1e+00 Abcb8
Delta time to tail flick, vehicle, before/after SA 36.05 1 1 100 0 1e+00 Abcb8
Delta time to tail flick, test, before/after SA 23.62 1 0 0 0 1e+00 Abcb8
Ambulatory time before self-admin 12 1 0 0 0 1e+00 Abcb8
Ambulatory time after self-admin 19.34 1 0 0 0 1e+00 Abcb8
Delay disc. indifference point, 0s delay 3.66 1 0 0 0 1e+00 Abcb8
Delay disc. indifference point, 4s delay 22.33 1 0 0 0 1e+00 Abcb8
Bouts of movement, locomotor time 1 19.6 1 0 0 0 1e+00 Abcb8
Total resting periods, locomotor time 1 13.99 1 0 0 0 1e+00 Abcb8
Vertical activity count, locomotor time 1 6.85 1 0 0 0 1e+00 Abcb8
Bouts of movement, locomotor time 2 13.89 1 0 0 0 1e+00 Abcb8
Total resting periods, locomotor time 2 10.98 1 0 0 0 1e+00 Abcb8
Distance moved, locomotor task time 2 5.36 1 0 0 0 1e+00 Abcb8
Vertical activity count, locomotor time 2 4.78 1 0 0 0 1e+00 Abcb8
Weight adjusted by age 5.54 1 0 0 0 1e+00 Abcb8
Locomotion in novel chamber 11.46 1 0 0 0 1e+00 Abcb8
Food seeking constrained by brief footshock 19.3 1 0 0 0 1e+00 Abcb8
Run reversals in cocaine runway, females 18.55 1 0 0 0 1e+00 Abcb8
K content in liver 5.2 1 0 0 0 1e+00 Abcb8
Rb content in liver 3.9 1 0 0 0 1e+00 Abcb8

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 0.96
Adipose alternative TSS 0 0 0.92
Adipose gene expression 0 0 1.03
Adipose isoform ratio 0 0 0.95
Adipose intron excision ratio 0 0 0.94
Adipose mRNA stability 0 0 1
BLA alternative polyA 0 0 0.96
BLA alternative TSS 0 0 0.91
BLA gene expression 0 0 0.99
BLA isoform ratio 0 0 0.95
BLA intron excision ratio 0 0 0.95
BLA mRNA stability 0 0 0.99
Brain alternative polyA 0 0 0.94
Brain alternative TSS 0 0 0.93
Brain gene expression 0 0 0.99
Brain isoform ratio 0 0 0.96
Brain intron excision ratio 0 0 0.94
Brain mRNA stability 0 0 0.99
Eye alternative polyA 0 0 1.01
Eye alternative TSS 0 0 0.94
Eye gene expression 0 0 0.97
Eye isoform ratio 0 0 1.02
Eye intron excision ratio 0 0 0.92
Eye mRNA stability 0 0 1.07
IL alternative polyA 0 0 1.03
IL alternative TSS 0 0 0.99
IL gene expression 0 0 0.99
IL isoform ratio 0 0 1.02
IL intron excision ratio 0 0 0.92
IL mRNA stability 0 0 1.01
LHb alternative polyA 0 0 0.96
LHb alternative TSS 0 0 0.78
LHb gene expression 0 0 0.97
LHb isoform ratio 0 0 0.96
LHb intron excision ratio 0 0 0.81
LHb mRNA stability 0 0 0.94
Liver alternative polyA 1 0 1.03
Liver alternative TSS 0 0 1.06
Liver gene expression 0 0 1.03
Liver isoform ratio 0 0 1.01
Liver intron excision ratio 0 0 0.96
Liver mRNA stability 0 0 1.04
NAcc alternative polyA 0 0 1.01
NAcc alternative TSS 0 0 0.95
NAcc gene expression 0 0 1
NAcc isoform ratio 0 0 0.98
NAcc intron excision ratio 0 0 0.9
NAcc mRNA stability 0 0 0.98
OFC alternative polyA 0 0 0.98
OFC alternative TSS 0 0 0.9
OFC gene expression 0 0 0.99
OFC isoform ratio 0 0 1.02
OFC intron excision ratio 0 0 0.85
OFC mRNA stability 0 0 1
PL alternative polyA 0 0 0.94
PL alternative TSS 0 0 0.91
PL gene expression 0 0 1
PL isoform ratio 0 0 0.95
PL intron excision ratio 0 0 0.93
PL mRNA stability 0 0 0.96
pVTA alternative polyA 0 0 0.95
pVTA alternative TSS 0 0 0.92
pVTA gene expression 0 0 0.99
pVTA isoform ratio 0 0 0.9
pVTA intron excision ratio 0 0 0.88
pVTA mRNA stability 0 0 0.96
RMTg alternative polyA 0 0 0.92
RMTg alternative TSS 0 0 0.92
RMTg gene expression 0 0 0.96
RMTg isoform ratio 0 0 0.97
RMTg intron excision ratio 0 0 0.93
RMTg mRNA stability 0 0 1.05