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Time to tail flick, vehicle, before self-admin

Time in sec to remove tail from noxious stimuli under vehicle conditions in the first tail flick before self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 198316555 199708396 1 1 3.2e-08 0.0023 0.055 61 Dhcr7

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Parametrial fat weight 3.7 1 0 0 0 1 Dhcr7
Retroperitoneal fat weight 2.4 1 0 0 0 1 Dhcr7
Tibialis anterior weight 4.5 1 0 0 0 1 Dhcr7
Times rat made contact with spout 4.0 1 0 0 0 1 Dhcr7
Indifference point function ln k 4.2 1 0 0 0 1 Dhcr7
Indifference point function log k 4.2 1 0 0 0 1 Dhcr7
Delay discounting total patch changes 6 sec 2.9 1 0 0 0 1 Dhcr7
Delay discounting water rate 0 sec 2.9 1 0 0 0 1 Dhcr7
Delay discounting water rate 12 sec 3.9 1 0 0 0 1 Dhcr7
Delay discounting water rate 18 sec 3.5 1 0 0 0 1 Dhcr7
Delay discounting water rate 24 sec 3.7 1 0 0 0 1 Dhcr7
Delay discounting water rate 6 sec 3.2 1 0 0 0 1 Dhcr7
Reaction time mean minus median 4.8 1 0 0 0 1 Dhcr7
Reaction time mean minus median AUC 7.3 1 0 0 0 1 Dhcr7
Reaction time false alarm rate 2.8 1 0 0 0 1 Dhcr7
Std. dev. reaction times 3.2 1 0 0 0 1 Dhcr7
Social responses 3.3 1 0 0 0 1 Dhcr7
Condit. Reinf. active minus inactive responses 3.7 1 0 0 0 1 Dhcr7
Condit. Reinf. active-inactive response ratio 4.0 1 0 0 0 1 Dhcr7
Conditioned locomotion 6.0 1 0 0 0 1 Dhcr7
Intermittent access intake day 1-15 change 10.3 1 0 0 0 1 Dhcr7
Intermittent access intake escalation 14.6 1 0 0 0 1 Dhcr7
Intermittent access intake escalation 2 7.5 1 0 0 0 1 Dhcr7
Intermittent access day 15 total infusions 13.6 1 0 0 0 1 Dhcr7
Intermittent access terminal intake (last 3 days) 7.5 1 0 0 0 1 Dhcr7
Intermittent access day 15 total locomotion 20.3 1 0 0 0 1 Dhcr7
Intermittent access total locomotion 8.1 1 0 0 0 1 Dhcr7
Intermittent access standard deviation 4.2 1 0 0 0 1 Dhcr7
Cocaine induced anxiety 6.0 1 0 0 0 1 Dhcr7
Post-drug Anxiety 3.5 1 0 0 0 1 Dhcr7
Baseline Anxiety 5.2 1 0 0 0 1 Dhcr7
Lifetime Intake 3.7 1 0 0 0 1 Dhcr7
Progressive ratio test 2 inactive lever presses 4.7 1 0 0 0 1 Dhcr7
Short access day 10 total infusions 4.9 1 0 0 0 1 Dhcr7
One hour access (0.3 mA shock) 15.1 1 0 0 0 1 Dhcr7
One hour access (shock baseline) 4.5 1 0 0 0 1 Dhcr7
Locomotion distance, session 2 3.8 1 0 0 0 1 Dhcr7
Condit. Reinf. lever presses 3.0 1 0 0 0 1 Dhcr7
Total zone transitions, hab. session 2 4.2 1 0 0 0 1 Dhcr7
Total zone transitions, NPP test 2.9 1 0 0 0 1 Dhcr7
Pavlov. Cond. lever latency 3.1 1 0 0 0 1 Dhcr7
Pavlov. Cond. index score 5.0 1 0 0 0 1 Dhcr7
Pavlov. Cond. latency score 3.9 1 0 0 0 1 Dhcr7
Pavlov. Cond. lever contacts 4.0 1 0 0 0 1 Dhcr7
Pavlov. Cond. magazine entry number 4.9 1 0 0 0 1 Dhcr7
Pavlov. Cond. lever-magazine prob. diff. 4.2 1 0 0 0 1 Dhcr7
Pavlov. Cond. response bias 6.0 1 0 0 0 1 Dhcr7
Bone: post-yield work 5.8 1 0 0 0 1 Dhcr7
Bone: tissue strength 5.2 1 0 0 0 1 Dhcr7
Delta time in open arm before/after self-admin 9.2 1 0 0 0 1 Dhcr7
Active lever presses in extinction session 6 6.9 1 0 0 0 1 Dhcr7
Time in open arm before self-admin 5.6 1 0 0 0 1 Dhcr7
Delta time to tail flick, vehicle, before/after SA 4.0 1 0 0 0 1 Dhcr7
Delay disc. indifference point, 4s delay 3.7 1 0 0 0 1 Dhcr7
Rest time, locomotor task time 1 4.0 1 0 0 0 1 Dhcr7
Run reversals in cocaine runway, males 17.5 1 0 0 0 1 Dhcr7
Mn content in liver 4.7 1 0 0 0 1 Dhcr7

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.08
Adipose alternative TSS 0 0.000 1.11
Adipose gene expression 0 0.000 0.99
Adipose isoform ratio 0 0.000 1.00
Adipose intron excision ratio 0 0.000 1.03
Adipose mRNA stability 0 0.000 0.99
BLA alternative polyA 0 0.000 1.16
BLA alternative TSS 0 0.000 1.00
BLA gene expression 0 0.000 1.01
BLA isoform ratio 0 0.000 0.98
BLA intron excision ratio 0 0.000 1.01
BLA mRNA stability 0 0.000 1.01
Brain alternative polyA 0 0.000 1.12
Brain alternative TSS 0 0.000 1.03
Brain gene expression 0 0.000 1.04
Brain isoform ratio 0 0.000 1.02
Brain intron excision ratio 0 0.000 0.99
Brain mRNA stability 0 0.000 1.00
Eye alternative polyA 0 0.000 0.78
Eye alternative TSS 0 0.000 0.92
Eye gene expression 0 0.000 0.97
Eye isoform ratio 0 0.000 1.01
Eye intron excision ratio 0 0.000 1.01
Eye mRNA stability 0 0.000 0.87
IL alternative polyA 0 0.000 1.06
IL alternative TSS 0 0.000 1.05
IL gene expression 0 0.000 0.97
IL isoform ratio 0 0.000 0.98
IL intron excision ratio 0 0.000 0.93
IL mRNA stability 0 0.000 0.98
LHb alternative polyA 0 0.000 1.15
LHb alternative TSS 0 0.000 0.76
LHb gene expression 0 0.000 1.03
LHb isoform ratio 0 0.000 0.97
LHb intron excision ratio 0 0.000 1.04
LHb mRNA stability 0 0.000 0.99
Liver alternative polyA 0 0.000 1.06
Liver alternative TSS 0 0.000 1.03
Liver gene expression 1 0.014 1.02
Liver isoform ratio 0 0.000 1.07
Liver intron excision ratio 0 0.000 0.99
Liver mRNA stability 0 0.000 1.03
NAcc alternative polyA 0 0.000 1.11
NAcc alternative TSS 0 0.000 1.02
NAcc gene expression 0 0.000 1.03
NAcc isoform ratio 0 0.000 1.02
NAcc intron excision ratio 0 0.000 1.04
NAcc mRNA stability 0 0.000 1.00
OFC alternative polyA 0 0.000 1.04
OFC alternative TSS 0 0.000 1.00
OFC gene expression 0 0.000 1.00
OFC isoform ratio 0 0.000 0.96
OFC intron excision ratio 0 0.000 0.96
OFC mRNA stability 0 0.000 1.00
PL alternative polyA 0 0.000 1.09
PL alternative TSS 0 0.000 1.06
PL gene expression 0 0.000 1.00
PL isoform ratio 0 0.000 0.98
PL intron excision ratio 0 0.000 0.97
PL mRNA stability 0 0.000 1.03

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.