Hub : Genes

Clpb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Clpb 0.11 0.07 2.2e-09 0.06 0.08 0.07 0.07 3.0e-07 8.4e-09 2.9e-08 3.7e-08
2 pVTA gene expression Clpb 0.2 0.09 0.0e+00 0.12 0.22 0.2 0.21 6.4e-10 1.5e-17 8.8e-16 1.1e-16
3 Brain gene expression Clpb 0.43 0.12 0.0e+00 0.36 0.49 0.49 0.49 2.4e-35 1.0e-51 1.9e-51 3.6e-51
4 IC gene expression Clpb 0.45 0.14 0.0e+00 0.29 0.42 0.43 0.42 1.1e-12 3.3e-19 1.9e-19 5.4e-19
5 BLA gene expression Clpb 0.5 0.14 0.0e+00 0.36 0.45 0.45 0.44 9.9e-20 5.0e-26 5.7e-26 2.2e-25
6 NAcc gene expression Clpb 0.45 0.12 0.0e+00 0.48 0.54 0.54 0.54 1.2e-81 3.7e-98 4.6e-98 2.0e-98
7 PL gene expression Clpb 0.47 0.14 0.0e+00 0.45 0.48 0.48 0.48 7.9e-54 1.0e-59 1.5e-59 5.6e-60
8 OFC gene expression Clpb 0.49 0.15 2.5e-10 0.31 0.33 0.33 0.35 3.3e-08 1.1e-08 1.3e-08 3.8e-09
9 IL gene expression Clpb 0.35 0.16 4.6e-05 0.13 0.1 0.04 0.12 4.4e-04 2.8e-03 3.8e-02 1.1e-03
10 PL mRNA stability Clpb 0.03 0.02 1.0e-03 0.03 0.03 0.03 0.03 6.2e-04 2.5e-04 3.3e-04 5.3e-04
11 Brain mRNA stability Clpb 0.12 0.06 5.7e-11 0.08 0.11 0.11 0.12 1.3e-07 8.4e-11 2.8e-10 7.2e-11
12 LHb gene expression Clpb 0.69 0.18 1.4e-05 0.13 0.09 0.22 0.13 5.4e-04 3.8e-03 5.2e-06 6.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.21.0-0.5-0.6-0.40.5-0.2-0.5-0.4-0.30.4-0.10.51.0
Area under the delay curve0.60.91.4-1.0-1.0-1.01.0-1.0-1.1-1.1-0.61.2-1.1-0.20.5
BMI with tail0.51.76.00.70.90.5-0.80.31.21.61.2-1.71.31.4-2.4
BMI without tail0.84.15.32.22.31.9-2.11.72.32.31.9-2.32.00.1-2.2
Body weight0.20.92.11.11.30.7-0.90.31.00.80.3-0.80.2-1.4-1.3
Weight adjusted by age0.10.40.70.80.80.7-0.70.70.70.50.5-0.30.4-0.7-0.2
Bone surface0.20.41.70.70.60.7-0.50.60.3-0.1-0.00.20.1-1.21.3
Bone volume0.10.21.10.30.30.3-0.20.20.0-0.3-0.30.3-0.2-1.01.0
Breakpoint value in progressive ratio session0.20.30.8-0.7-0.7-0.70.6-0.6-0.5-0.2-0.30.3-0.20.9-0.7
Number of licking bursts1.23.85.7-2.4-2.3-2.42.3-2.3-2.1-1.9-1.81.7-1.70.80.3
Context. condit. distance diff. score3.74.56.02.42.42.4-2.42.52.42.22.2-2.12.0-0.3-0.7
Locomotion velocity, session 10.50.63.7-0.2-0.10.1-0.10.30.20.70.8-0.80.91.9-0.6
Locomotion distance, session 11.82.33.31.31.31.4-1.41.51.51.81.8-1.81.71.1-1.0
Locomotion velocity, session 20.81.01.40.80.80.8-0.80.81.01.21.2-1.21.21.0-1.2
Locomotion distance, session 21.41.93.21.11.21.1-1.21.11.41.61.6-1.61.51.1-1.8
Locomotion velocity, session 30.70.81.21.01.01.1-1.01.11.00.90.9-0.80.8-0.0-0.1
Locomotion distance, session 31.11.32.21.21.11.3-1.21.51.21.21.3-1.11.30.30.4
Stereotopy head waving bouts, day 30.50.61.0-0.6-0.6-0.70.7-0.9-0.7-0.9-1.00.9-1.0-0.80.1
Stereotopy head waving duration, day 30.30.30.50.60.60.6-0.60.60.70.60.6-0.60.60.1-0.2
Locomotion velocity, session 70.30.31.40.10.20.2-0.20.30.40.60.7-0.60.71.2-0.8
Locomotion distance, session 70.20.30.4-0.6-0.6-0.60.6-0.7-0.5-0.5-0.40.5-0.60.1-0.2
Stereotopy head waving bouts, day 73.23.75.92.32.22.4-2.22.42.11.81.8-1.71.9-0.70.5
Stereotopy head waving duration, day 73.24.06.02.42.32.4-2.32.42.22.01.9-1.82.0-0.60.1
Locomotion velocity, session 81.31.62.41.61.51.5-1.51.51.41.21.2-1.11.0-0.6-0.3
Locomotion distance, session 84.05.87.12.62.72.6-2.72.52.72.62.5-2.52.30.1-1.7
Degree of sensitization distance1.21.32.3-0.8-0.7-1.11.0-1.4-1.0-1.2-1.31.2-1.5-1.1-0.7
Degree of sensitization stereotypy5.76.39.73.02.93.1-2.93.12.72.42.3-2.22.3-1.00.3
Conditioned locomotion0.81.01.6-0.9-0.9-1.00.9-1.1-1.0-1.1-1.21.1-1.3-0.6-0.0
Cocaine response after cond. corrected0.81.22.0-1.4-1.3-1.41.3-1.4-1.2-1.0-1.00.9-1.00.5-0.1
Cocaine response after cond. not corrected0.20.20.8-0.7-0.6-0.60.6-0.5-0.4-0.1-0.1-0.0-0.00.9-0.0
Cocaine response before conditioning2.83.44.81.81.82.0-1.92.22.02.02.1-2.02.20.7-0.0
Saline control response0.81.14.51.31.31.2-1.11.00.80.20.1-0.00.1-2.10.8
Bone: connectivity density0.30.52.10.10.10.4-0.30.70.50.60.8-0.71.11.50.6
Bone: cortical apparent density1.42.23.3-1.6-1.6-1.81.6-1.8-1.7-1.5-1.51.4-1.50.1-0.1
Bone: cortical area0.10.10.60.30.30.2-0.2-0.00.1-0.1-0.20.1-0.2-0.8-0.1
Bone: cortical porosity0.10.10.4-0.1-0.2-0.10.2-0.0-0.3-0.3-0.30.3-0.2-0.30.7
Bone: cortical porosity0.10.10.70.1-0.00.1-0.00.2-0.1-0.2-0.20.2-0.1-0.30.8
Bone: cortical thickness0.10.21.0-0.5-0.4-0.50.4-0.5-0.3-0.10.0-0.00.11.0-0.6
Bone: cortical thickness0.00.00.10.10.10.0-0.1-0.00.1-0.0-0.0-0.0-0.1-0.3-0.3
Bone: cortical tissue density1.42.13.3-1.6-1.6-1.81.7-1.8-1.7-1.4-1.51.4-1.50.1-0.1
Condit. Reinf. active minus inactive responses0.30.32.40.30.20.1-0.1-0.1-0.1-0.4-0.50.5-0.7-1.5-0.1
Condit. Reinf. active-inactive response ratio0.60.64.30.30.20.1-0.1-0.1-0.3-0.7-0.80.8-0.9-2.10.6
Condit. Reinf. active responses0.40.51.2-0.4-0.4-0.50.5-0.7-0.7-0.8-0.90.9-1.0-1.1-0.0
Condit. Reinf. inactive responses0.20.30.5-0.6-0.6-0.60.6-0.7-0.5-0.4-0.40.3-0.40.5-0.4
Incentive salience index mean0.20.31.5-0.0-0.0-0.20.2-0.3-0.4-0.5-0.60.6-0.8-1.2-0.1
Condit. Reinf. lever presses0.00.00.10.10.10.10.00.00.00.10.1-0.10.10.1-0.4
Condit. Reinf. active minus inactive responses3.75.610.03.23.12.9-2.92.72.51.91.6-1.61.4-2.6-0.2
Condit. Reinf. active-inactive response ratio0.91.42.21.51.41.4-1.41.41.31.21.0-1.01.0-0.70.0
Condit. Reinf. active responses4.86.812.63.53.53.2-3.22.82.71.91.7-1.61.3-3.2-0.4
Condit. Reinf. inactive responses1.62.46.02.22.11.8-1.91.41.50.80.7-0.70.4-2.5-0.6
Condit. Reinf. lever presses10.214.824.44.94.94.7-4.64.34.33.53.2-3.23.0-2.7-1.0
Condit. Reinf. lever reinforcers received5.47.613.93.73.63.4-3.33.02.92.11.8-1.81.5-3.2-0.4
Conditioned reinforcement - actives0.10.30.60.50.50.6-0.50.60.60.50.8-0.50.60.10.3
Conditioned reinforcement - inactives0.61.62.3-1.3-1.4-1.41.4-1.4-1.4-1.5-0.91.5-1.4-0.20.5
Conditioned locomotion1.31.93.71.21.21.4-1.31.61.41.51.9-1.51.71.00.0
Patch foraging indifference point 0 sec0.92.64.02.02.01.9-1.81.81.81.61.4-1.41.5-0.90.4
Patch foraging indifference point AUC0.10.10.40.50.50.3-0.40.20.30.1-0.0-0.1-0.1-0.6-0.4
Delay disc. indifference point, 0s delay0.50.51.01.01.00.9-0.80.70.80.60.8-0.50.4-0.5-0.4
Delay disc. indifference point, 16s delay1.31.82.8-1.2-1.3-1.31.3-1.3-1.3-1.6-1.11.7-1.6-0.91.3
Delay disc. indifference point, 2s delay0.10.10.60.40.40.3-0.20.10.0-0.20.30.3-0.3-0.80.3
Delay disc. indifference point, 24s delay1.72.73.6-1.8-1.8-1.91.8-1.9-1.8-1.8-1.41.9-1.8-0.20.3
Delay disc. indifference point, 4s delay0.20.31.30.70.70.5-0.50.20.20.00.30.2-0.3-1.2-0.2
Delay disc. indifference point, 8s delay0.30.40.6-0.8-0.8-0.70.8-0.7-0.8-0.8-0.40.8-0.70.10.1
Indifference point function ln k0.20.50.80.60.60.7-0.70.90.70.80.9-0.70.90.30.5
Indifference point function log k0.20.50.80.60.60.7-0.70.90.70.80.9-0.70.90.30.5
Patch foraging total patch changes 0 sec0.82.43.61.91.91.8-1.71.81.81.61.4-1.51.5-0.70.3
Patch foraging total patch changes 12 sec0.30.41.30.90.90.7-0.60.50.70.20.2-0.10.0-1.2-0.4
Patch foraging total patch changes 18 sec0.41.01.71.31.31.2-1.11.11.10.80.7-0.70.7-0.90.1
Patch foraging total patch changes 24 sec0.20.51.91.01.00.8-0.80.60.80.30.2-0.30.1-1.40.1
Patch foraging total patch changes 6 sec0.50.91.31.11.11.1-1.01.01.20.90.9-0.90.9-0.1-0.4
Patch foraging time to switch 0 sec1.14.36.6-2.6-2.5-2.42.4-2.3-2.3-2.1-1.82.0-1.71.20.4
Patch foraging water rate 0 sec0.83.14.72.22.12.1-2.12.02.01.71.5-1.61.5-0.9-0.4
Patch foraging water rate 12 sec1.35.47.82.22.32.3-2.32.32.62.72.6-2.82.60.9-1.5
Patch foraging water rate 18 sec1.94.45.82.42.42.3-2.32.22.32.22.1-2.21.9-0.5-1.2
Patch foraging water rate 24 sec1.01.42.51.01.01.1-1.01.21.21.51.4-1.61.40.7-0.5
Patch foraging water rate 6 sec1.32.02.81.41.41.4-1.31.41.61.71.6-1.71.60.4-0.6
Seeking ratio, delayed vs. immediate footshock0.71.02.0-1.4-1.4-1.21.2-1.0-1.0-0.7-0.50.7-0.30.71.0
Distance traveled before self-admin0.10.32.1-0.3-0.2-0.30.1-0.30.00.20.1-0.40.20.7-1.4
Distance traveled after self-admin0.51.02.30.30.40.5-0.60.70.81.01.5-1.21.21.5-0.9
Extensor digitorum longus weight0.10.20.4-0.5-0.4-0.60.5-0.7-0.4-0.4-0.50.3-0.40.0-0.5
Bone: elastic displacement0.60.73.6-1.1-1.1-0.90.9-0.6-0.6-0.3-0.10.10.11.9-0.1
Bone: elastic work0.81.07.3-1.2-1.1-0.90.9-0.5-0.50.00.2-0.30.52.7-0.2
Bone: endosteal estimation0.40.95.71.01.00.8-0.80.60.50.1-0.20.1-0.3-2.40.8
Bone: endosteal perimeter0.51.24.41.51.41.3-1.31.10.90.40.2-0.20.2-2.10.4
Epididymis fat weight0.10.50.9-0.9-0.9-1.00.9-1.0-0.7-0.6-0.70.5-0.50.5-0.5
Delta time in closed arm before/after self-admin1.91.82.7-1.4-1.3-1.51.4-1.6-1.4-1.4-1.71.5-1.4-0.4-0.1
Delta time in open arm before/after self-admin1.21.42.41.51.51.5-1.41.41.20.80.7-0.70.6-1.50.6
Diff in mean of infusions in LGA sessions2.95.36.8-2.5-2.5-2.42.5-2.4-2.5-2.6-2.42.6-2.5-0.41.2
Delay discount exponential model param0.50.71.10.90.90.9-1.01.01.01.00.4-1.00.90.0-0.3
Extinction: sum of active levers before priming0.00.00.10.10.10.1-0.0-0.0-0.1-0.20.20.3-0.2-0.2-0.3
Active lever presses in extinction session 61.81.83.21.21.11.3-1.21.51.31.51.8-1.51.61.2-0.5
Bone: final force1.32.13.1-1.2-1.2-1.31.3-1.4-1.5-1.7-1.81.7-1.6-1.11.0
Bone: final moment0.91.42.2-0.9-0.9-1.01.0-1.2-1.2-1.4-1.51.5-1.4-1.10.9
Food consumed during 24 hour testing period1.83.75.52.22.12.3-2.22.32.12.01.9-1.92.0-0.20.3
Glucose0.20.30.60.40.40.5-0.40.50.50.70.7-0.70.80.50.0
Heart weight0.40.61.11.01.01.0-0.91.00.80.40.5-0.50.5-0.70.5
Delay discount hyperbolic model param0.50.71.10.80.80.9-0.90.91.01.00.4-1.01.00.1-0.4
Intermittent access intake day 1-15 change0.53.06.11.31.41.4-1.51.51.82.02.5-2.22.11.6-0.8
Intermittent access intake escalation0.63.36.41.51.51.7-1.71.81.82.12.5-2.22.21.5-0.5
Intermittent access intake escalation 20.40.71.20.70.70.7-0.80.80.80.91.1-1.01.00.7-0.1
Intermitt. access day 1 inactive lever presses0.33.44.8-2.1-2.1-2.22.2-2.2-2.0-2.0-1.51.9-1.90.10.2
Intermitt. access day 15 inactive lever presses0.00.30.4-0.7-0.7-0.60.6-0.5-0.5-0.50.20.4-0.40.70.1
Intermitt. access escalation Index0.00.00.3-0.0-0.0-0.00.0-0.0-0.1-0.1-0.1-0.0-0.1-0.30.6
Intermittent access day 1 total infusions0.20.61.11.00.91.0-0.90.90.70.40.3-0.20.4-1.10.6
Intermittent access day 15 total infusions0.51.32.11.31.31.3-1.31.41.21.11.4-1.11.2-0.00.1
Intermittent access terminal intake (last 3 days)0.71.21.71.31.31.3-1.21.31.21.01.2-1.01.0-0.40.1
Intermittent access total infusions1.01.11.81.31.31.3-1.31.21.20.91.0-0.90.9-0.60.0
Intermittent access day 1 locomotion0.20.32.1-0.1-0.1-0.00.20.0-0.3-0.5-0.30.5-0.3-0.61.4
Intermittent access day 15 total locomotion0.20.81.80.60.60.8-0.71.00.80.91.3-0.91.20.90.3
Intermittent access total locomotion0.40.50.80.80.80.9-0.70.90.70.60.7-0.40.7-0.30.8
Intermittent access standard deviation0.10.62.40.40.50.3-0.50.20.60.71.0-0.90.60.7-1.5
Left kidney weight0.10.61.10.91.00.6-0.80.40.90.70.4-0.70.4-0.7-1.0
Right kidney weight0.10.52.50.90.90.5-0.70.30.60.3-0.0-0.2-0.1-1.6-0.8
Cocaine induced anxiety1.64.46.0-2.4-2.4-2.42.4-2.3-2.4-2.2-1.92.3-2.00.40.8
Post-drug Anxiety3.13.55.3-1.8-1.9-1.91.9-1.9-2.1-2.2-2.02.3-2.1-0.60.9
Baseline Anxiety0.50.82.81.21.21.1-1.11.00.80.4-0.0-0.30.2-1.70.3
Tail length0.42.214.91.81.71.4-1.30.90.8-0.0-0.40.3-0.6-3.90.3
Length with tail0.42.015.71.51.41.0-1.00.50.6-0.2-0.60.4-0.9-4.00.5
Length without tail0.10.31.9-0.1-0.0-0.20.2-0.3-0.2-0.3-0.60.4-0.6-1.40.8
Times rat made contact with spout0.50.50.7-0.6-0.6-0.70.7-0.7-0.7-0.7-0.80.8-0.8-0.60.8
Lifetime Intake1.41.72.61.61.61.6-1.51.51.51.21.3-1.11.2-0.60.0
Liver weight, left0.71.31.9-0.9-0.9-1.11.1-1.2-1.1-1.3-1.41.2-1.3-1.20.8
Liver weight, right1.01.83.0-1.0-1.0-1.31.2-1.5-1.2-1.4-1.71.5-1.7-1.50.2
Locomotor activity0.60.91.21.11.11.0-1.00.91.11.01.0-0.90.9-0.1-0.9
Locomotor testing distance0.81.93.31.81.81.6-1.61.41.61.31.1-1.11.1-1.0-0.7
Locomotor testing rearing0.10.52.11.01.00.8-0.80.50.70.30.2-0.10.1-1.5-0.3
Locomotion in novel chamber0.20.31.8-0.4-0.4-0.30.3-0.1-0.00.30.2-0.40.51.3-0.4
Locomotion in novel chamber post-restriction0.51.52.31.31.21.4-1.21.51.21.21.3-1.31.40.20.5
Fecal boli incidents, locomotor time 10.71.82.5-1.5-1.6-1.41.5-1.2-1.5-1.4-0.71.3-1.01.50.8
Change in fecal boli incidents, locomotor task0.20.31.40.50.50.4-0.50.40.50.3-0.2-0.30.2-1.20.1
Time >=10cm from walls, locomotor time 10.30.31.00.70.60.7-0.60.70.40.30.1-0.20.3-1.00.7
Bouts of movement, locomotor time 10.40.51.2-0.3-0.4-0.40.5-0.4-0.5-0.9-0.80.9-0.8-1.11.1
Total resting periods, locomotor time 10.30.41.1-0.5-0.6-0.50.6-0.5-0.5-0.8-0.60.8-0.6-0.41.0
Rest time, locomotor task time 10.20.32.3-0.3-0.4-0.20.3-0.1-0.2-0.5-0.30.4-0.3-0.71.5
Distance moved, locomotor task time 10.00.10.90.10.20.1-0.1-0.00.20.40.2-0.30.10.2-1.0
Vertical activity count, locomotor time 10.00.10.7-0.1-0.1-0.30.1-0.4-0.2-0.2-0.30.3-0.4-0.2-0.8
Time >=10cm from walls, locomotor time 20.41.16.41.31.21.1-1.10.80.70.2-0.1-0.0-0.1-2.50.5
Bouts of movement, locomotor time 20.51.65.4-0.4-0.5-0.70.7-1.0-1.0-1.5-1.61.6-1.7-2.30.7
Total resting periods, locomotor time 20.41.83.8-0.8-0.8-1.00.9-1.2-1.2-1.6-1.61.7-1.8-1.90.6
Rest time, locomotor task time 20.81.42.5-1.6-1.6-1.51.4-1.4-1.2-1.0-0.90.9-0.90.8-0.0
Distance moved, locomotor task time 21.31.72.91.71.71.5-1.61.41.41.21.2-1.00.9-1.3-0.1
Vertical activity count, locomotor time 20.10.21.20.20.20.0-0.2-0.2-0.1-0.3-0.10.5-0.6-1.1-0.1
Light reinforcement 10.31.13.9-1.4-1.3-1.31.2-1.2-0.9-0.4-0.40.3-0.22.0-0.8
Light reinforcement 21.12.46.60.70.70.9-0.91.21.31.81.9-1.92.02.6-1.4
Bone: marrow area0.30.75.30.80.80.6-0.60.40.3-0.1-0.40.2-0.4-2.30.8
Bone: maximum diameter0.71.33.61.61.51.4-1.41.21.10.60.5-0.50.4-1.90.0
Bone: maximum force0.40.81.2-0.7-0.7-0.80.8-0.8-1.0-1.1-1.11.1-1.0-0.71.0
Bone: maximum moment0.20.40.6-0.4-0.4-0.40.5-0.5-0.6-0.7-0.80.7-0.6-0.60.8
Mean time between licks in bursts0.31.810.71.71.71.3-1.30.80.9-0.0-0.20.3-0.5-3.3-0.4
Mean num. licks in bursts1.13.04.62.12.12.1-2.02.11.91.61.5-1.51.5-1.10.1
Cd content in liver0.60.71.2-0.6-0.7-0.70.8-0.8-0.9-1.1-1.01.1-1.0-0.80.5
Co content in liver0.50.64.50.80.80.6-0.60.40.3-0.3-0.30.4-0.4-2.10.5
Cu content in liver0.30.42.70.30.30.1-0.1-0.1-0.1-0.4-0.50.5-0.6-1.60.3
Fe content in liver0.00.10.1-0.2-0.2-0.20.2-0.2-0.2-0.2-0.20.2-0.2-0.20.4
K content in liver0.40.40.8-0.6-0.6-0.80.6-0.9-0.7-0.5-0.60.5-0.7-0.1-0.6
Mg content in liver0.20.30.70.40.40.3-0.40.30.40.60.5-0.60.50.4-0.9
Mn content in liver0.40.53.0-0.9-0.8-0.70.6-0.5-0.4-0.00.1-0.10.21.7-0.0
Na content in liver1.21.31.81.21.21.3-1.31.31.21.41.3-1.31.20.1-0.1
Rb content in liver0.20.21.30.10.00.10.10.1-0.2-0.3-0.30.4-0.3-0.91.1
Se content in liver3.13.76.4-2.5-2.5-2.32.3-2.1-2.1-1.6-1.51.5-1.31.50.9
Sr content in liver2.32.03.01.11.11.3-1.31.41.41.61.7-1.71.71.4-0.8
Zn content in liver2.12.43.41.81.81.7-1.81.61.71.61.5-1.61.2-0.5-1.2
Bone: minimum diameter0.30.64.90.40.40.1-0.2-0.2-0.1-0.5-0.80.7-0.9-2.20.1
Time in familiar zone, hab. session 10.20.20.30.50.50.5-0.50.40.40.30.3-0.30.3-0.3-0.3
Time in novel zone, hab. session 10.50.60.7-0.8-0.8-0.80.8-0.8-0.8-0.8-0.90.8-0.9-0.30.5
Total zone transitions, hab. session 10.60.81.20.80.70.9-0.91.00.81.11.1-1.11.10.7-0.1
Total locomotion distance, hab. session 10.60.81.7-0.6-0.5-0.80.7-1.1-0.9-0.9-1.10.9-1.3-1.2-0.6
Locomotion velocity, hab. session 10.40.61.2-0.5-0.5-0.70.6-1.0-0.7-0.7-0.90.7-1.1-0.8-0.9
Time in familiar zone, hab. session 20.91.13.11.41.31.2-1.21.01.00.50.4-0.40.2-1.8-0.3
Time in novel zone, hab. session 20.50.53.8-0.6-0.5-0.40.4-0.3-0.10.40.5-0.50.62.0-0.4
Total zone transitions, hab. session 23.24.05.22.22.22.3-2.22.32.22.22.1-2.12.10.2-0.8
Total locomotion distance, hab. session 20.40.52.30.60.70.2-0.4-0.10.20.0-0.20.0-0.5-1.5-1.5
Locomotion velocity, hab. session 20.40.52.50.50.50.1-0.3-0.30.1-0.1-0.40.2-0.7-1.6-1.4
Novel to familiar place preference ratio0.91.23.1-0.5-0.5-0.70.7-0.9-0.9-1.3-1.41.4-1.4-1.70.8
Novelty place preference0.81.02.9-0.4-0.4-0.60.6-0.8-0.8-1.1-1.21.3-1.3-1.70.6
Time in novel zone, NPP test0.70.93.2-0.2-0.3-0.40.4-0.7-0.7-1.0-1.21.2-1.3-1.80.6
Total zone transitions, NPP test1.11.62.60.90.91.0-1.01.11.11.51.6-1.61.61.6-0.9
Total locomotion distance, NPP test0.30.43.5-0.2-0.1-0.40.2-0.6-0.10.1-0.0-0.2-0.20.5-1.9
Locomotion velocity, NPP test0.30.43.2-0.4-0.3-0.60.4-0.8-0.30.0-0.1-0.1-0.20.7-1.8
Intraocular pressure0.20.41.20.0-0.00.3-0.20.70.30.40.6-0.50.91.11.0
Delta distance traveled before/after self-admin1.01.11.81.21.11.3-1.11.31.00.81.1-0.70.9-0.41.0
Delta ambulatory time before/after self-admin0.61.01.81.11.11.2-1.11.31.00.91.2-0.71.0-0.21.0
Parametrial fat weight0.40.84.1-0.1-0.00.1-0.20.30.41.01.0-1.31.12.0-0.7
Pavlov. Cond. lever latency0.20.30.9-0.7-0.7-0.70.6-0.6-0.4-0.3-0.20.2-0.10.9-0.4
Pavlov. Cond. magazine entry latency2.53.25.02.22.22.1-2.12.02.01.71.6-1.61.4-1.1-0.5
Pavlov. Cond. change in total contacts0.40.42.20.80.70.7-0.60.60.40.0-0.00.1-0.1-1.50.8
Pavlov. Cond. index score1.31.62.71.71.61.6-1.51.51.41.11.0-1.00.9-1.1-0.1
Pavlov. Cond. latency score1.01.22.11.51.41.4-1.31.31.20.90.8-0.70.7-1.20.1
Pavlov. Cond. lever contacts0.40.50.90.90.90.9-0.90.90.80.60.5-0.50.4-0.80.2
Pavlov. Cond. magazine entry number1.82.33.9-2.0-1.9-1.91.8-1.8-1.6-1.3-1.21.2-1.11.3-0.1
Pavlov. Cond. intertrial magazine entries0.91.11.5-1.2-1.2-1.11.2-1.1-1.2-1.1-1.01.1-0.90.20.6
Pavlov. Cond. lever-magazine prob. diff.1.11.32.31.51.51.5-1.41.41.21.00.9-0.90.8-1.00.0
Pavlov. Cond. response bias1.11.42.11.51.41.4-1.41.41.31.21.0-1.10.9-0.7-0.3
Pavlov. Cond. lever latency14.920.931.8-5.6-5.6-5.45.4-5.1-5.1-4.4-4.24.2-3.92.01.8
Pavlov. Cond. magazine entry latency6.49.010.83.13.23.1-3.23.13.33.33.3-3.33.10.8-2.3
Pavlov. Cond. change in total contacts8.019.428.95.45.35.2-5.14.94.94.34.2-4.13.8-1.7-1.8
Pavlov. Cond. index score10.917.124.85.05.04.8-4.84.64.64.14.0-3.93.7-1.2-2.2
Pavlov. Cond. latency score10.016.022.54.74.74.6-4.64.44.54.04.0-3.93.7-0.8-2.2
Pavlov. Cond. lever contacts12.418.428.75.45.35.1-5.14.84.84.13.9-3.83.6-2.1-1.6
Pavlov. Cond. magazine entry number9.512.315.2-3.9-3.9-3.93.9-3.8-3.9-3.7-3.73.6-3.5-0.22.2
Pavlov. Cond. intertrial magazine entries0.41.03.7-0.2-0.3-0.40.5-0.6-0.7-1.1-1.21.2-1.3-1.90.7
Pavlov. Cond. lever-magazine prob. diff.10.516.123.64.94.84.7-4.74.44.54.03.9-3.83.5-1.2-2.2
Pavlov. Cond. response bias15.621.631.95.65.65.4-5.45.25.24.64.4-4.34.1-1.6-2.1
Time in closed arm before self-admin1.83.24.12.02.02.0-2.02.02.01.91.8-1.81.7-0.4-0.8
Time in closed arm after self-admin0.50.50.8-0.9-0.9-0.90.8-0.8-0.8-0.7-0.80.8-0.60.2-0.0
Time in open arm before self-admin2.73.36.0-2.4-2.4-2.32.2-2.1-1.9-1.4-1.01.2-1.12.20.1
Time in open arm after self-admin0.00.00.10.10.10.1-0.10.10.0-0.10.20.1-0.1-0.40.4
Bone: periosteal estimation0.20.53.00.80.80.7-0.70.50.50.1-0.10.0-0.1-1.70.4
Bone: periosteal perimeter0.40.81.51.21.21.1-1.10.91.00.70.5-0.60.4-1.2-0.2
Bone: post-yield work0.10.10.30.40.40.3-0.40.30.30.20.1-0.20.1-0.50.1
Progressive ratio test 1 active lever presses0.00.00.30.10.00.2-0.10.30.10.00.10.00.20.00.6
Progressive ratio test 1 breakpoint0.00.00.40.10.00.2-0.10.30.0-0.00.10.10.2-0.00.6
Progressive ratio test 1 inactive lever presses0.10.41.0-0.7-0.7-0.60.7-0.5-0.6-0.7-0.30.6-0.40.01.0
Progressive ratio test 2 active lever presses0.10.10.30.40.40.5-0.30.40.30.10.40.00.2-0.50.5
Progressive ratio test 2 breakpoint0.10.20.30.50.50.5-0.40.50.30.20.4-0.00.3-0.40.5
Progressive ratio test 2 inactive lever presses0.00.10.50.30.30.4-0.30.40.40.30.7-0.30.50.3-0.1
Incentive Sensitization - Responses0.10.20.40.60.60.6-0.50.50.40.20.4-0.10.3-0.60.1
Incentive Sensitization - Breakpoint0.10.30.50.70.70.6-0.60.60.50.40.6-0.30.4-0.4-0.0
Sum of active levers in priming session hrs 5-60.40.40.70.60.60.5-0.60.50.60.60.8-0.60.60.3-0.8
Progressive ratio0.61.72.71.11.11.3-1.11.41.41.51.5-1.51.70.9-1.2
Food seeking constrained by brief footshock1.21.52.51.61.61.4-1.51.21.31.00.7-1.00.7-0.8-1.2
Seeking ratio, punishment vs. effort0.10.31.90.50.50.2-0.4-0.00.1-0.2-0.50.2-0.6-1.4-0.2
Retroperitoneal fat weight0.62.55.2-1.8-1.6-2.11.9-2.3-1.7-1.4-1.71.1-1.6-0.2-0.6
Reaction time number correct0.10.20.40.20.20.3-0.20.40.50.50.6-0.60.60.6-0.4
Reaction time mean minus median0.00.20.80.50.50.4-0.50.30.30.20.0-0.1-0.1-0.9-0.2
Reaction time mean minus median AUC0.00.20.60.60.60.5-0.60.40.50.30.2-0.20.1-0.8-0.1
Reaction time num false alarms2.64.45.9-2.2-2.2-2.32.3-2.4-2.3-2.2-2.32.3-2.2-0.30.7
Reaction time num false alarms AUC1.63.64.8-2.1-2.0-2.12.1-2.2-2.1-2.0-2.12.1-1.9-0.10.7
Reaction time trials correct on left0.10.20.40.20.20.3-0.20.40.50.50.6-0.60.60.6-0.4
Reaction time trials on left0.10.20.50.20.20.3-0.20.30.50.50.6-0.60.60.7-0.4
Reaction time mean1.63.65.0-1.9-1.9-2.11.9-2.2-2.1-2.1-2.12.1-2.2-0.70.0
Reaction time mean AUC1.63.95.2-2.0-2.0-2.12.0-2.3-2.2-2.2-2.12.2-2.2-0.50.2
Median of all reaction times3.14.96.7-2.3-2.3-2.52.4-2.6-2.5-2.4-2.32.4-2.5-0.30.1
Reaction time omissions0.20.40.7-0.6-0.6-0.80.8-0.9-0.6-0.6-0.70.5-0.6-0.3-0.1
Reaction time false alarm rate2.53.54.7-2.0-2.0-2.12.0-2.2-2.1-2.0-2.12.1-1.9-0.20.6
Reaction time premature initiation rate0.60.92.01.31.31.1-1.20.91.00.60.5-0.60.2-1.4-0.6
Reaction time premature initiations0.30.91.41.21.21.1-1.10.91.10.80.8-0.90.5-0.7-0.7
Std. dev. reaction times0.41.22.6-0.6-0.6-0.80.7-1.1-1.0-1.3-1.41.4-1.5-1.60.3
Reaction time trials completed0.10.20.50.20.20.3-0.20.30.50.50.6-0.60.60.7-0.4
Reaction time trials AUC0.00.10.20.20.20.2-0.20.30.40.40.4-0.50.40.5-0.4
Run reversals in cocaine runway, females0.40.53.70.50.60.3-0.40.00.30.3-0.3-0.1-0.1-1.0-1.9
Run reversals in cocaine runway, males0.50.51.8-0.8-0.8-0.70.8-0.6-0.7-0.7-0.30.7-0.50.21.3
Latency to leave start box in cocaine runway1.41.92.5-1.6-1.6-1.61.5-1.5-1.5-1.6-0.91.5-1.40.51.2
Latency to leave start box in cocaine runway, F2.32.84.1-1.7-1.7-1.81.7-1.8-1.8-2.0-1.52.0-2.0-0.41.2
Latency to leave start box in cocaine runway, M0.30.32.1-0.4-0.4-0.30.3-0.1-0.10.10.6-0.20.31.40.1
Std. dev. time between licks in bursts0.30.64.10.50.40.1-0.2-0.3-0.1-0.7-0.80.8-1.0-2.0-0.6
Total sessions with >9 infusions1.72.13.31.81.81.8-1.71.71.61.31.2-1.21.2-0.9-0.1
Short access day 1 total inactive lever presses0.20.51.0-0.5-0.6-0.60.7-0.6-0.8-1.0-0.30.9-0.9-0.40.4
Short access day 10 total inactive lever presses0.32.33.1-1.7-1.7-1.71.7-1.7-1.7-1.7-1.41.5-1.40.30.6
Short access day 1 total infusions0.81.62.91.71.71.6-1.51.41.30.80.8-0.70.6-1.6-0.2
Short access day 10 total infusions1.01.72.61.61.61.6-1.51.61.51.21.2-1.11.1-0.80.1
Short access total infusions1.42.03.21.81.71.8-1.71.71.61.21.2-1.21.2-1.00.2
Short access day 1 locomotion0.61.01.81.11.01.2-1.01.41.01.01.1-0.91.20.00.4
Short access day 10 total locomotion0.21.01.31.11.11.1-1.01.01.11.11.0-1.01.0-0.0-0.7
Short access total locomotion0.30.40.80.60.60.7-0.60.80.60.70.8-0.60.90.30.3
One hour access (0.3 mA shock)0.70.81.21.01.01.0-1.01.01.10.91.0-0.91.00.10.2
Compulsive drug intake0.30.52.3-1.0-1.0-0.70.8-0.5-0.5-0.2-0.20.10.21.50.5
One hour access (shock baseline)0.92.33.41.81.81.7-1.71.61.71.51.8-1.51.4-0.2-0.7
Social response proportion0.40.50.9-0.7-0.7-0.80.7-1.0-0.7-0.5-0.60.5-0.60.4-0.7
Social responses0.91.22.0-0.9-0.8-1.11.0-1.4-1.1-1.1-1.41.1-1.4-0.9-0.3
Social time0.91.42.3-1.5-1.5-1.51.4-1.4-1.3-0.9-0.90.8-0.81.10.0
Soleus weight0.51.62.7-1.0-1.0-1.31.2-1.6-1.3-1.4-1.61.3-1.6-1.0-0.7
Bone: stiffness2.03.65.3-1.6-1.7-1.81.8-2.0-2.0-2.2-2.32.2-2.3-1.31.1
Tibialis anterior weight0.10.31.4-0.1-0.1-0.30.3-0.5-0.3-0.7-0.80.7-0.7-1.20.2
Time to tail flick, vehicle, before self-admin1.11.32.41.21.21.2-1.31.21.41.31.0-1.61.3-0.1-0.2
Time to tail flick, vehicle, after self-admin0.20.40.70.70.60.8-0.70.80.60.30.8-0.10.2-0.80.7
Time to tail flick, test, before self-admin0.91.03.91.31.21.2-1.11.00.80.30.2-0.10.3-2.00.9
Time to tail flick, test, after self-admin0.50.54.50.40.40.2-0.3-0.1-0.1-0.5-0.50.6-0.8-2.1-0.2
Delta time to tail flick, vehicle, before/after SA0.20.30.8-0.4-0.5-0.30.5-0.3-0.6-0.7-0.00.9-0.6-0.30.6
Delta time to tail flick, test, before/after SA0.50.61.0-1.0-0.9-1.00.8-1.0-0.7-0.5-0.30.3-0.60.6-0.9
Tibia length0.30.81.51.21.11.2-1.11.20.90.70.7-0.50.8-0.80.4
Ambulatory time before self-admin0.10.20.9-0.4-0.4-0.40.3-0.4-0.2-0.00.0-0.20.10.7-1.0
Ambulatory time after self-admin0.81.33.00.80.81.0-1.01.21.11.21.7-1.21.41.0-0.5
Bone: tissue strength0.60.74.1-0.1-0.10.1-0.10.40.40.80.9-0.81.12.0-0.4
Total heroin consumption0.40.50.90.70.80.6-0.70.60.80.80.6-0.80.70.0-1.0
Bone: trabecular number0.30.51.9-1.0-0.9-0.70.8-0.5-0.6-0.4-0.20.30.01.40.8
Bone: trabecular spacing1.31.92.81.21.21.3-1.31.31.41.71.6-1.71.50.9-1.2
Bone: trabecular thickness1.31.83.0-0.9-1.0-1.11.1-1.2-1.4-1.6-1.71.7-1.7-1.60.9
Bone: trabecular tissue density3.86.610.0-2.2-2.2-2.52.5-2.8-2.7-2.9-3.13.0-3.2-2.00.8
Water consumed over 24 hours0.10.20.6-0.6-0.6-0.50.6-0.4-0.5-0.3-0.40.3-0.20.30.8
Number of responses in last shaping day2.33.05.9-1.4-1.5-1.61.7-1.7-1.9-2.0-2.42.1-1.9-1.21.2