Hub : Traits

Short access total locomotion

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166093700	167491708	1	1	8.38e-08	1.43e-02	4.72e-05	Tead1
2	chr9	280752	1529977	1	1	1.45e-08	1.95e-02	5.70e-01	Stap2
3	chr9	75969545	77365260	1	1	2.09e-49	1.89e-01	1.00e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	5.39	2	1	33.3	0	1e+00	Tead1 Zfand2b
BMI without tail	28.45	2	1	33.3	0	1e+00	Stap2 Zfand2b
Epididymis fat weight	111.28	1	1	33.3	0	1e+00	Zfand2b
Heart weight	71.7	1	1	33.3	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	33.3	0	1e+00	Zfand2b
Right kidney weight	54.05	1	1	33.3	0	1e+00	Zfand2b
Tail length	63.81	2	1	33.3	0	1e+00	Stap2 Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	33.3	0	1e+00	Zfand2b
Liver weight, left	4.42	1	0	0	0	1e+00	Stap2
Liver weight, right	17.57	1	1	33.3	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1e+00	Zfand2b
Intraocular pressure	51.69	1	1	33.3	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	33.3	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	33.3	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.19	2	0	0	0	1e+00	Tead1 Zfand2b
Patch foraging indifference point AUC	24.2	1	1	33.3	0	1e+00	Zfand2b
Indifference point function ln k	54.42	1	1	33.3	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	16.31	2	1	33.3	0	1e+00	Tead1 Zfand2b
Patch foraging total patch changes 12 sec	9.53	1	0	0	0	1e+00	Tead1
Patch foraging total patch changes 18 sec	48.28	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 6 sec	15.72	2	1	33.3	0	1e+00	Tead1 Zfand2b
Patch foraging time to switch 0 sec	19.75	2	1	33.3	0	1e+00	Tead1 Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	10.78	2	0	0	0	1e+00	Tead1 Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	33.3	0	1e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1e+00	Zfand2b
Locomotor testing distance	47.2	1	1	33.3	0	1e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	33.3	0	1e+00	Zfand2b
Light reinforcement 1	19.25	1	1	33.3	0	1e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	33.3	0	1e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean	20.18	2	1	33.3	0	1e+00	Tead1 Zfand2b
Reaction time mean AUC	33.75	1	1	33.3	0	1e+00	Zfand2b
Median of all reaction times	11.02	2	0	0	0	1e+00	Tead1 Zfand2b
Reaction time omissions	46.56	1	1	33.3	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	33.3	0	1e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	33.3	0	1e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1e+00	Zfand2b
Social time	6.17	1	0	0	0	1e+00	Stap2
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	80.61	2	1	33.3	0	1e+00	Stap2 Zfand2b
Conditioned reinforcement - inactives	72.86	2	1	33.3	0	1e+00	Tead1 Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	56.97	3	1	33.3	0	1e+00	Stap2 Tead1 Zfand2b
Intermittent access intake escalation	117.41	1	1	33.3	0	1e+00	Zfand2b
Intermittent access intake escalation 2	7.7	1	0	0	0	1e+00	Tead1
Intermitt. access day 1 inactive lever presses	89.31	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermitt. access day 15 inactive lever presses	152.36	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermittent access day 1 total infusions	47.98	3	2	66.7	0	1e+00	Stap2 Tead1 Zfand2b
Intermittent access day 15 total infusions	21.89	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	33.3	0	1e+00	Zfand2b
Intermittent access total infusions	26.61	2	1	33.3	0	1e+00	Stap2 Tead1
Intermittent access day 1 locomotion	17.41	3	1	33.3	0	1e+00	Stap2 Tead1 Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	33.3	0	1e+00	Zfand2b
Intermittent access total locomotion	9.21	3	0	0	0	1e+00	Stap2 Tead1 Zfand2b
Intermittent access standard deviation	229.11	2	1	33.3	0	1e+00	Tead1 Zfand2b
Cocaine induced anxiety	125.35	1	1	33.3	0	1e+00	Zfand2b
Baseline Anxiety	393.92	1	1	33.3	0	1e+00	Zfand2b
Lifetime Intake	27.65	2	1	33.3	0	1e+00	Stap2 Tead1
Incentive Sensitization - Responses	172.91	2	2	66.7	0	1e+00	Tead1 Zfand2b
Incentive Sensitization - Breakpoint	167.46	2	2	66.7	0	1e+00	Tead1 Zfand2b
Progressive ratio test 1 active lever presses	26.09	2	2	66.7	0	1e+00	Tead1 Zfand2b
Progressive ratio test 1 breakpoint	21.61	2	0	0	0	1e+00	Tead1 Zfand2b
Progressive ratio test 1 inactive lever presses	6.43	1	0	0	0	1e+00	Tead1
Progressive ratio test 2 active lever presses	76.88	2	2	66.7	0	1e+00	Tead1 Zfand2b
Progressive ratio test 2 breakpoint	75.43	2	2	66.7	0	1e+00	Tead1 Zfand2b
Progressive ratio test 2 inactive lever presses	27.23	3	1	33.3	0	1e+00	Stap2 Tead1 Zfand2b
Total sessions with >9 infusions	17.37	2	0	0	0	1e+00	Stap2 Tead1
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	28.11	2	1	33.3	0	1e+00	Tead1 Zfand2b
Short access day 1 total infusions	9.83	2	0	0	0	1e+00	Stap2 Tead1
Short access day 10 total infusions	61.37	2	1	33.3	0	1e+00	Stap2 Tead1
Short access total infusions	38.87	2	1	33.3	0	1e+00	Stap2 Tead1
Short access day 1 locomotion	52.66	3	1	33.3	0	1e+00	Stap2 Tead1 Zfand2b
Short access day 10 total locomotion	220.95	2	1	33.3	0	1e+00	Stap2 Zfand2b
Compulsive drug intake	32.41	3	1	33.3	0	1e+00	Stap2 Tead1 Zfand2b
One hour access (0.3 mA shock)	15.24	2	0	0	0	1e+00	Stap2 Zfand2b
Number of responses in last shaping day	41.39	2	1	33.3	0	1e+00	Tead1 Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Locomotion velocity, session 3	5.05	1	0	0	0	1e+00	Stap2
Bone: cortical porosity	5.3	1	0	0	0	1e+00	Tead1
Bone: cortical porosity	7.17	1	0	0	0	1e+00	Tead1
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Breakpoint value in progressive ratio session	12.33	2	0	0	0	1e+00	Stap2 Tead1
Distance traveled before self-admin	6.84	2	0	0	0	1e+00	Tead1 Zfand2b
Distance traveled after self-admin	10.31	2	0	0	0	1e+00	Tead1 Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1e+00	Zfand2b
Delta ambulatory time before/after self-admin	6.19	1	0	0	0	1e+00	Zfand2b
Time in closed arm before self-admin	27.9	2	1	33.3	0	1e+00	Tead1 Zfand2b
Time in closed arm after self-admin	8.36	1	0	0	0	1e+00	Tead1
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.82	2	0	0	0	1e+00	Stap2 Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	33.3	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	40.25	2	1	33.3	0	1e+00	Tead1 Zfand2b
Ambulatory time before self-admin	17.27	2	0	0	0	1e+00	Tead1 Zfand2b
Ambulatory time after self-admin	19.2	1	0	0	0	1e+00	Tead1
Total heroin consumption	6.81	1	0	0	0	1e+00	Tead1
Area under the delay curve	19.17	2	1	33.3	0	1e+00	Stap2 Zfand2b
Delay disc. indifference point, 0s delay	7.01	2	0	0	0	1e+00	Stap2 Zfand2b
Delay disc. indifference point, 16s delay	39.98	2	1	33.3	0	1e+00	Stap2 Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	40.46	2	1	33.3	0	1e+00	Stap2 Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	33.3	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	33.3	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	33.3	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	33.3	0	1e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	33.3	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	33.3	0	1e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	6.97	2	0	0	0	1e+00	Tead1 Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Run reversals in cocaine runway, females	28.57	2	1	33.3	0	1e+00	Stap2 Zfand2b
Latency to leave start box in cocaine runway	23.51	2	1	33.3	0	1e+00	Stap2 Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, M	15.16	1	0	0	0	1e+00	Stap2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1
Adipose	alternative TSS	0	0	1.03
Adipose	gene expression	1	0	1.07
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	1.04
Adipose	mRNA stability	0	0	1.06
BLA	alternative polyA	0	0	1.02
BLA	alternative TSS	0	0	1.07
BLA	gene expression	0	0	1.05
BLA	isoform ratio	0	0	1.04
BLA	intron excision ratio	0	0	0.96
BLA	mRNA stability	0	0	1.05
Brain	alternative polyA	0	0	1.07
Brain	alternative TSS	0	0	1.04
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.08
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	1.04
Eye	alternative polyA	0	0	1.04
Eye	alternative TSS	0	0	1.07
Eye	gene expression	0	0	1.09
Eye	isoform ratio	0	0	1.21
Eye	intron excision ratio	0	0	1.05
Eye	mRNA stability	0	0	1.14
IL	alternative polyA	0	0	1.02
IL	alternative TSS	0	0	1.09
IL	gene expression	0	0	1.02
IL	isoform ratio	0	0	1.01
IL	intron excision ratio	0	0	0.92
IL	mRNA stability	0	0	1.04
LHb	alternative polyA	0	0	0.94
LHb	alternative TSS	0	0	1.11
LHb	gene expression	0	0	1.04
LHb	isoform ratio	0	0	1
LHb	intron excision ratio	0	0	0.84
LHb	mRNA stability	0	0	1.08
Liver	alternative polyA	0	0	0.99
Liver	alternative TSS	0	0	1.12
Liver	gene expression	0	0	1.05
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	1.06
Liver	mRNA stability	0	0	1.06
NAcc	alternative polyA	0	0	1.08
NAcc	alternative TSS	1	0	1.03
NAcc	gene expression	0	0	1.06
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	0.98
NAcc	mRNA stability	0	0	1.08
OFC	alternative polyA	0	0	1.01
OFC	alternative TSS	0	0	1.23
OFC	gene expression	0	0	1.01
OFC	isoform ratio	0	0	0.99
OFC	intron excision ratio	0	0	0.93
OFC	mRNA stability	0	0	1.08
PL	alternative polyA	0	0	1.06
PL	alternative TSS	0	0	1.02
PL	gene expression	0	0	1.06
PL	isoform ratio	0	0	1.07
PL	intron excision ratio	1	0	1.03
PL	mRNA stability	0	0	1.09
pVTA	alternative polyA	0	0	1.09
pVTA	alternative TSS	0	0	1.01
pVTA	gene expression	0	0	1.06
pVTA	isoform ratio	0	0	1.05
pVTA	intron excision ratio	0	0	0.99
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	0	0	1.01
RMTg	alternative TSS	0	0	1.07
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1.03
RMTg	intron excision ratio	0	0	1.01
RMTg	mRNA stability	0	0	1.05