Hub : Traits

Short access total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	5	74868378	76264539	1	1	2.73e-15	7.90e-03	1e-03	RGD1566134
2	11	39057816	40174684	1	1	3.47e-12	8.63e-03	1e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.79	1	0	0	0	1.00e+00	RGD1566134
Body weight	2.65	1	0	0	0	1.00e+00	RGD1566134
Heart weight	4.41	1	0	0	0	1.00e+00	Epha6
Left kidney weight	3.16	1	0	0	0	1.00e+00	RGD1566134
Parametrial fat weight	16.59	1	1	50	0	1.00e+00	Epha6
Intraocular pressure	5.23	1	0	0	0	1.00e+00	Epha6
Tibia length	2.39	1	0	0	0	1.00e+00	Epha6
Food consumed during 24 hour testing period	5.72	2	0	0	0	1.00e+00	Epha6 RGD1566134
Times rat made contact with spout	14.73	1	0	0	0	1.00e+00	Epha6
Water consumed over 24 hours	13.45	2	0	0	0	1.00e+00	Epha6 RGD1566134
Delay discounting total patch changes 12 sec	11.65	1	0	0	0	1.00e+00	Epha6
Delay discounting total patch changes 18 sec	13.14	1	0	0	0	1.00e+00	Epha6
Delay discounting total patch changes 24 sec	8.19	1	0	0	0	1.00e+00	RGD1566134
Delay discounting total patch changes 6 sec	8.48	2	0	0	0.17	8.31e-01	Epha6 RGD1566134
Delay discounting time to switch 0 sec	5.85	1	0	0	0	1.00e+00	RGD1566134
Delay discounting water rate 18 sec	10.67	1	0	0	0	1.00e+00	Epha6
Locomotor activity	6.88	1	0	0	0	1.00e+00	Epha6
Locomotor testing distance	7.95	1	0	0	0	1.00e+00	Epha6
Reaction time premature initiation rate	8.75	1	0	0	0	1.00e+00	Epha6
Reaction time premature initiations	5.85	1	0	0	0	1.00e+00	Epha6
Conditioned locomotion	11.84	2	0	0	0	1.00e+00	Epha6 RGD1566134
Cocaine response before conditioning	6.74	1	0	0	0	1.00e+00	Epha6
Saline control response	13.95	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. lever presses	8.41	2	0	0	-0.15	8.48e-01	Epha6 RGD1566134
Pavlov. Cond. lever latency	15.84	2	1	50	0	1.00e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry latency	14.11	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. change in total contacts	11.46	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. index score	15.45	1	1	50	0	1.00e+00	RGD1566134
Pavlov. Cond. latency score	17.48	1	1	50	0	1.00e+00	RGD1566134
Pavlov. Cond. lever contacts	11.84	2	1	50	0	1.00e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry number	10.17	2	0	0	0	1.00e+00	Epha6 RGD1566134
Pavlov. Cond. lever-magazine prob. diff.	13.75	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. response bias	14.97	1	1	50	0	1.00e+00	RGD1566134
Conditioned reinforcement - actives	21.15	1	0	0	0	1.00e+00	Epha6
Conditioned reinforcement - inactives	27.02	1	1	50	0	1.00e+00	Epha6
Intermittent access day 1 total infusions	18.04	2	1	50	0.98	2.00e-02	Epha6 RGD1566134
Intermittent access day 15 total infusions	13.65	1	0	0	0	1.00e+00	Epha6
Intermittent access terminal intake (last 3 days)	19.39	1	0	0	0	1.00e+00	Epha6
Intermittent access total infusions	17.65	1	0	0	0	1.00e+00	Epha6
Cocaine induced anxiety	15.39	1	0	0	0	1.00e+00	Epha6
Post-drug Anxiety	5.89	1	0	0	0	1.00e+00	Epha6
Baseline Anxiety	15.71	2	0	0	-0.09	9.09e-01	Epha6 RGD1566134
Lifetime Intake	24.87	2	2	100	0.99	1.16e-02	Epha6 RGD1566134
Incentive Sensitization - Responses	9.27	1	0	0	0	1.00e+00	Epha6
Incentive Sensitization - Breakpoint	8.83	1	0	0	0	1.00e+00	Epha6
Progressive ratio test 1 active lever presses	20.06	2	1	50	0	1.00e+00	Epha6 RGD1566134
Progressive ratio test 1 breakpoint	23.29	2	1	50	0	1.00e+00	Epha6 RGD1566134
Progressive ratio test 1 inactive lever presses	9.17	1	0	0	0	1.00e+00	Epha6
Progressive ratio test 2 active lever presses	25.61	2	1	50	0	1.00e+00	Epha6 RGD1566134
Progressive ratio test 2 breakpoint	21.02	2	1	50	0	1.00e+00	Epha6 RGD1566134
Progressive ratio test 2 inactive lever presses	29.3	1	1	50	0	1.00e+00	Epha6
Total sessions with >9 infusions	14.17	2	0	0	1	3.85e-03	Epha6 RGD1566134
Short access day 1 total inactive lever presses	6.58	1	0	0	0	1.00e+00	Epha6
Short access day 1 total infusions	26.87	2	1	50	0.98	2.20e-02	Epha6 RGD1566134
Short access day 10 total infusions	14.03	1	0	0	0	1.00e+00	RGD1566134
Short access day 1 locomotion	9.05	1	0	0	0	1.00e+00	RGD1566134
Compulsive drug intake	11.5	1	0	0	0	1.00e+00	RGD1566134
One hour access (0.3 mA shock)	33.5	1	1	50	0	1.00e+00	Epha6
One hour access (shock baseline)	19.56	1	0	0	0	1.00e+00	Epha6
Context. condit. distance diff. score	6.72	1	0	0	0	1.00e+00	RGD1566134
Locomotion distance, session 1	10.11	1	0	0	0	1.00e+00	Epha6
Stereotopy head waving bouts, day 3	7.78	2	0	0	0	1.00e+00	Epha6 RGD1566134
Stereotopy head waving duration, day 3	10.95	1	0	0	0	1.00e+00	RGD1566134
Locomotion velocity, session 7	6.82	1	0	0	0	1.00e+00	Epha6
Locomotion distance, session 7	12.27	1	0	0	0	1.00e+00	Epha6
Stereotopy head waving bouts, day 7	16.96	1	1	50	0	1.00e+00	RGD1566134
Stereotopy head waving duration, day 7	11.77	1	0	0	0	1.00e+00	RGD1566134
Locomotion distance, session 8	5.02	1	0	0	0	1.00e+00	Epha6
Degree of sensitization stereotypy	16.12	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. active minus inactive responses	10.44	2	0	0	0	1.00e+00	Epha6 RGD1566134
Condit. Reinf. active-inactive response ratio	8.4	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. active responses	9.38	2	0	0	0	1.00e+00	Epha6 RGD1566134
Condit. Reinf. inactive responses	8.3	1	0	0	0	1.00e+00	RGD1566134
Incentive salience index mean	9.09	2	0	0	0	1.00e+00	Epha6 RGD1566134
Condit. Reinf. lever presses	7.4	2	0	0	0	1.00e+00	Epha6 RGD1566134
Time in familiar zone, hab. session 1	9.26	1	0	0	0	1.00e+00	Epha6
Time in novel zone, hab. session 1	6.66	1	0	0	0	1.00e+00	Epha6
Total zone transitions, hab. session 1	8.13	1	0	0	0	1.00e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	0	1.00e+00	Epha6
Locomotion velocity, hab. session 1	8.12	1	0	0	0	1.00e+00	Epha6
Time in familiar zone, hab. session 2	29.91	1	1	50	0	1.00e+00	Epha6
Time in novel zone, hab. session 2	25.18	1	1	50	0	1.00e+00	Epha6
Total zone transitions, hab. session 2	7.43	1	0	0	0	1.00e+00	Epha6
Total locomotion distance, hab. session 2	7.61	2	0	0	0	1.00e+00	Epha6 RGD1566134
Locomotion velocity, hab. session 2	7.9	2	0	0	0	1.00e+00	Epha6 RGD1566134
Pavlov. Cond. lever latency	11.55	2	0	0	0	1.00e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry latency	31.42	1	1	50	0	1.00e+00	Epha6
Pavlov. Cond. change in total contacts	7.31	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. index score	24.26	1	1	50	0	1.00e+00	Epha6
Pavlov. Cond. latency score	22.39	1	1	50	0	1.00e+00	Epha6
Pavlov. Cond. lever contacts	20.49	1	1	50	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry number	12.84	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. intertrial magazine entries	6.47	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. lever-magazine prob. diff.	22.92	1	1	50	0	1.00e+00	Epha6
Pavlov. Cond. response bias	24.61	1	1	50	0	1.00e+00	Epha6
Bone: apparent density	11.64	1	0	0	0	1.00e+00	RGD1566134
Bone surface	6.99	2	0	0	-0.2	7.96e-01	Epha6 RGD1566134
Bone volume	8.02	1	0	0	0	1.00e+00	RGD1566134
Bone: connectivity density	4.61	1	0	0	0	1.00e+00	Epha6
Bone: cortical apparent density	5.36	1	0	0	0	1.00e+00	RGD1566134
Bone: cortical thickness	13.39	1	0	0	0	1.00e+00	Epha6
Bone: cortical tissue density	5.24	1	0	0	0	1.00e+00	RGD1566134
Bone: endosteal estimation	4.06	2	0	0	0	1.00e+00	Epha6 RGD1566134
Bone: endosteal perimeter	6.45	1	0	0	0	1.00e+00	RGD1566134
Bone: marrow area	3.84	2	0	0	0	1.00e+00	Epha6 RGD1566134
Bone: maximum diameter	6.16	2	0	0	1	2.82e-03	Epha6 RGD1566134
Bone: periosteal perimeter	4.91	1	0	0	0	1.00e+00	Epha6
Bone: stiffness	6.97	1	0	0	0	1.00e+00	Epha6
Bone: trabecular thickness	10.89	1	0	0	0	1.00e+00	RGD1566134
Active lever presses in extinction session 6	7.43	1	0	0	0	1.00e+00	RGD1566134
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1.00e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8	1	0	0	0	1.00e+00	Epha6
Area under the delay curve	6.54	1	0	0	0	1.00e+00	Epha6
Delay disc. indifference point, 0s delay	10.4	2	0	0	0	1.00e+00	Epha6 RGD1566134
Delay disc. indifference point, 4s delay	14.3	2	0	0	0	1.00e+00	Epha6 RGD1566134
Delay disc. indifference point, 8s delay	7.89	1	0	0	0	1.00e+00	Epha6
Delay discount exponential model param	6.64	1	0	0	0	1.00e+00	Epha6
Delay discount hyperbolic model param	6.66	1	0	0	0	1.00e+00	Epha6
Bouts of movement, locomotor time 1	6.82	2	0	0	0	1.00e+00	Epha6 RGD1566134
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1.00e+00	Epha6
Time >=10cm from walls, locomotor time 2	10.81	1	0	0	0	1.00e+00	RGD1566134
Rest time, locomotor task time 2	5.68	1	0	0	0	1.00e+00	Epha6
Weight adjusted by age	7.91	1	0	0	0	1.00e+00	RGD1566134
Seeking ratio, delayed vs. immediate footshock	16.13	2	1	50	0.17	8.31e-01	Epha6 RGD1566134
Locomotion in novel chamber post-restriction	15.32	1	0	0	0	1.00e+00	Epha6
Run reversals in cocaine runway, females	11.07	1	0	0	0	1.00e+00	RGD1566134
Latency to leave start box in cocaine runway	8.54	1	0	0	0	1.00e+00	Epha6
Fe content in liver	8.75	1	0	0	0	1.00e+00	RGD1566134
Na content in liver	12.03	2	0	0	0	1.00e+00	Epha6 RGD1566134
Rb content in liver	5.26	1	0	0	0	1.00e+00	RGD1566134
Se content in liver	11.12	1	0	0	0	1.00e+00	Epha6
Zn content in liver	15.04	1	0	0	0	1.00e+00	RGD1566134

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.12
Adipose	alternative TSS	0	0	1.24
Adipose	gene expression	0	0	1.11
Adipose	isoform ratio	0	0	1.14
Adipose	intron excision ratio	0	0	1.12
Adipose	mRNA stability	0	0	1.1
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	1.12
BLA	gene expression	0	0	1.11
BLA	isoform ratio	0	0	1.1
BLA	intron excision ratio	0	0	1.12
BLA	mRNA stability	0	0	1.16
Brain	alternative polyA	0	0	1.07
Brain	alternative TSS	0	0	1.06
Brain	gene expression	0	0	1.11
Brain	isoform ratio	0	0	1.15
Brain	intron excision ratio	0	0	1.06
Brain	mRNA stability	0	0	1.1
Eye	alternative polyA	0	0	1.24
Eye	alternative TSS	0	0	0.92
Eye	gene expression	0	0	1.29
Eye	isoform ratio	0	0	1.11
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	1.19
IL	alternative polyA	0	0	1.08
IL	alternative TSS	0	0	1.05
IL	gene expression	0	0	1.09
IL	isoform ratio	0	0	1.02
IL	intron excision ratio	0	0	1.11
IL	mRNA stability	0	0	1.15
LHb	alternative polyA	0	0	1.15
LHb	alternative TSS	0	0	1.08
LHb	gene expression	0	0	1.17
LHb	isoform ratio	0	0	1.07
LHb	intron excision ratio	0	0	1.09
LHb	mRNA stability	0	0	1.12
Liver	alternative polyA	0	0	1.06
Liver	alternative TSS	0	0	1.05
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.1
Liver	intron excision ratio	2	0	1.13
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	0	0	1.06
NAcc	alternative TSS	0	0	1.16
NAcc	gene expression	0	0	1.1
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.12
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	1.16
OFC	alternative TSS	0	0	0.8
OFC	gene expression	0	0	1.12
OFC	isoform ratio	0	0	1.08
OFC	intron excision ratio	0	0	1.06
OFC	mRNA stability	0	0	1.17
PL	alternative polyA	0	0	1.08
PL	alternative TSS	2	0.2	1.14
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.11
PL	intron excision ratio	0	0	1.06
PL	mRNA stability	0	0	1.17