Hub : Traits

Short access total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166093700	167491708	1	1	3.41e-15	8.92e-03	7.21e-07	Tead1
2	chr7	14449451	15768722	1	1	2.16e-12	9.10e-02	1.00e+00	LOC102551633
3	chr8	33211184	34601262	1	1	4.66e-15	1.17e-01	1.51e-15	Ddx25

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.35	1	0	0	0	1e+00	Tead1
BMI without tail	4.08	1	0	0	0	1e+00	Ddx25
Right kidney weight	2.2	1	0	0	0	1e+00	Ddx25
Tail length	6.06	1	0	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	0	1e+00	Ddx25
Patch foraging indifference point 0 sec	9.16	2	0	0	0	1e+00	LOC102551633 Tead1
Patch foraging total patch changes 0 sec	8.18	2	0	0	0	1e+00	LOC102551633 Tead1
Patch foraging total patch changes 12 sec	9.53	1	0	0	0	1e+00	Tead1
Patch foraging total patch changes 6 sec	6.2	2	0	0	0	1e+00	LOC102551633 Tead1
Patch foraging time to switch 0 sec	6.02	1	0	0	0	1e+00	Tead1
Patch foraging water rate 24 sec	8.95	1	0	0	0	1e+00	Tead1
Locomotor activity	4.34	2	0	0	0	1e+00	Ddx25 LOC102551633
Locomotor testing distance	4.33	2	0	0	0	1e+00	Ddx25 LOC102551633
Reaction time mean	4.52	2	0	0	0	1e+00	Ddx25 Tead1
Median of all reaction times	4.38	1	0	0	0	1e+00	Tead1
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	10.26	3	0	0	0	1e+00	Ddx25 LOC102551633 Tead1
Conditioned locomotion	53.64	1	1	33.3	0	1e+00	LOC102551633
Intermittent access intake day 1-15 change	43.02	2	1	33.3	0	1e+00	Ddx25 Tead1
Intermittent access intake escalation	41.26	1	1	33.3	0	1e+00	Ddx25
Intermittent access intake escalation 2	18.07	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Intermitt. access day 1 inactive lever presses	17.35	2	1	33.3	0	1e+00	Ddx25 Tead1
Intermitt. access day 15 inactive lever presses	25.67	2	1	33.3	0	1e+00	Ddx25 Tead1
Intermitt. access escalation Index	36.25	2	1	33.3	0	1e+00	Ddx25 LOC102551633
Intermittent access day 1 total infusions	37.92	2	1	33.3	0	1e+00	LOC102551633 Tead1
Intermittent access day 15 total infusions	19.55	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Intermittent access terminal intake (last 3 days)	51.19	2	2	66.7	0	1e+00	Ddx25 LOC102551633
Intermittent access total infusions	28.05	3	2	66.7	0	1e+00	Ddx25 LOC102551633 Tead1
Intermittent access day 1 locomotion	11.44	1	0	0	0	1e+00	Tead1
Intermittent access day 15 total locomotion	32.88	1	1	33.3	0	1e+00	LOC102551633
Intermittent access total locomotion	10.08	2	0	0	0	1e+00	LOC102551633 Tead1
Intermittent access standard deviation	15.63	2	0	0	0	1e+00	Ddx25 Tead1
Cocaine induced anxiety	12.68	1	0	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	0	1e+00	Ddx25
Lifetime Intake	34.3	3	2	66.7	0	1e+00	Ddx25 LOC102551633 Tead1
Incentive Sensitization - Responses	21.05	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Incentive Sensitization - Breakpoint	20.9	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Progressive ratio test 1 active lever presses	17.18	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Progressive ratio test 1 breakpoint	22.54	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Progressive ratio test 1 inactive lever presses	16.85	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Progressive ratio test 2 active lever presses	30.08	2	1	33.3	0	1e+00	Ddx25 Tead1
Progressive ratio test 2 breakpoint	31.55	2	1	33.3	0	1e+00	Ddx25 Tead1
Progressive ratio test 2 inactive lever presses	22.41	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Total sessions with >9 infusions	21.06	2	0	0	0	1e+00	Ddx25 Tead1
Short access day 1 total inactive lever presses	7.07	1	0	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	15.16	2	0	0	0	1e+00	LOC102551633 Tead1
Short access day 1 total infusions	44.74	3	2	66.7	0	1e+00	Ddx25 LOC102551633 Tead1
Short access day 10 total infusions	55.77	3	3	100	0	1e+00	Ddx25 LOC102551633 Tead1
Short access day 1 locomotion	16.31	2	0	0	0	1e+00	LOC102551633 Tead1
Short access day 10 total locomotion	11.38	1	0	0	0	1e+00	Ddx25
Short access total locomotion	27.61	1	1	33.3	0	1e+00	Tead1
Compulsive drug intake	22.25	1	0	0	0	1e+00	Tead1
One hour access (0.3 mA shock)	70.35	1	1	33.3	0	1e+00	Ddx25
One hour access (shock baseline)	23.24	2	1	33.3	0	1e+00	Ddx25 LOC102551633
Number of responses in last shaping day	20.89	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone: cortical area	7.52	1	0	0	0	1e+00	Ddx25
Bone: cortical porosity	5.3	1	0	0	0	1e+00	Tead1
Bone: cortical porosity	7.17	1	0	0	0	1e+00	Tead1
Bone: cortical thickness	4.39	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1e+00	Ddx25
Bone: final force	4.62	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: final moment	4.16	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: maximum force	5.29	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: maximum moment	4.67	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: minimum diameter	3.6	1	0	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1e+00	Ddx25
Bone: stiffness	4.85	2	0	0	0	1e+00	Ddx25 LOC102551633
Breakpoint value in progressive ratio session	11.08	1	0	0	0	1e+00	Tead1
Distance traveled before self-admin	26.05	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Distance traveled after self-admin	23.47	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Delta time in closed arm before/after self-admin	6.42	1	0	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	24.99	2	0	0	0	1e+00	Ddx25 LOC102551633
Active lever presses in extinction session 6	9.49	1	0	0	0	1e+00	Ddx25
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	13.84	2	0	0	0	1e+00	Ddx25 LOC102551633
Time in closed arm before self-admin	11.48	1	0	0	0	1e+00	Tead1
Time in closed arm after self-admin	8.01	2	0	0	0	1e+00	LOC102551633 Tead1
Time in open arm before self-admin	28.75	1	1	33.3	0	1e+00	LOC102551633
Time in open arm after self-admin	5.82	1	0	0	0	1e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	18.99	1	0	0	0	1e+00	LOC102551633
Time to tail flick, vehicle, before self-admin	31.43	2	1	33.3	0	1e+00	Ddx25 LOC102551633
Time to tail flick, vehicle, after self-admin	51.7	1	1	33.3	0	1e+00	LOC102551633
Time to tail flick, test, before self-admin	5.88	1	0	0	0	1e+00	Ddx25
Delta time to tail flick, vehicle, before/after SA	64.27	2	1	33.3	0	1e+00	LOC102551633 Tead1
Ambulatory time before self-admin	16.28	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Ambulatory time after self-admin	13.83	3	0	0	0	1e+00	Ddx25 LOC102551633 Tead1
Total heroin consumption	15.5	3	1	33.3	0	1e+00	Ddx25 LOC102551633 Tead1
Seeking ratio, delayed vs. immediate footshock	7.27	2	0	0	0	1e+00	LOC102551633 Tead1
Run reversals in cocaine runway, males	8.37	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	10.76	1	0	0	0	1e+00	Ddx25
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	33.3	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633
Sr content in liver	9.74	1	0	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.08
Adipose	alternative TSS	0	0	1.11
Adipose	gene expression	1	0	1.1
Adipose	isoform ratio	0	0	1.13
Adipose	intron excision ratio	0	0	1.15
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.12
BLA	alternative TSS	0	0	1.16
BLA	gene expression	0	0	1.12
BLA	isoform ratio	0	0	1.16
BLA	intron excision ratio	0	0	1.14
BLA	mRNA stability	0	0	1.14
Brain	alternative polyA	0	0	1.13
Brain	alternative TSS	0	0	1.08
Brain	gene expression	0	0	1.12
Brain	isoform ratio	0	0	1.11
Brain	intron excision ratio	0	0	1.12
Brain	mRNA stability	0	0	1.1
Eye	alternative polyA	0	0	1.09
Eye	alternative TSS	0	0	1.15
Eye	gene expression	0	0	1.26
Eye	isoform ratio	0	0	1.15
Eye	intron excision ratio	0	0	1.12
Eye	mRNA stability	0	0	1.25
IL	alternative polyA	0	0	1.14
IL	alternative TSS	0	0	1.06
IL	gene expression	0	0	1.1
IL	isoform ratio	0	0	1.12
IL	intron excision ratio	0	0	1.15
IL	mRNA stability	0	0	1.14
LHb	alternative polyA	0	0	1.12
LHb	alternative TSS	0	0	1.37
LHb	gene expression	0	0	1.13
LHb	isoform ratio	0	0	1.19
LHb	intron excision ratio	0	0	1.12
LHb	mRNA stability	0	0	1.19
Liver	alternative polyA	0	0	1.11
Liver	alternative TSS	0	0	1.19
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.15
Liver	intron excision ratio	0	0	1.16
Liver	mRNA stability	0	0	1.11
NAcc	alternative polyA	0	0	1.17
NAcc	alternative TSS	1	0	1.11
NAcc	gene expression	0	0	1.11
NAcc	isoform ratio	0	0	1.13
NAcc	intron excision ratio	0	0	1.14
NAcc	mRNA stability	0	0	1.13
OFC	alternative polyA	0	0	1.22
OFC	alternative TSS	0	0	1.18
OFC	gene expression	0	0	1.09
OFC	isoform ratio	0	0	1.1
OFC	intron excision ratio	0	0	1.07
OFC	mRNA stability	0	0	1.1
PL	alternative polyA	0	0	1.14
PL	alternative TSS	0	0	1.13
PL	gene expression	0	0	1.11
PL	isoform ratio	0	0	1.18
PL	intron excision ratio	0	0	1.12
PL	mRNA stability	0	0	1.15
pVTA	alternative polyA	0	0	1.17
pVTA	alternative TSS	0	0	1.14
pVTA	gene expression	0	0	1.13
pVTA	isoform ratio	0	0	1.2
pVTA	intron excision ratio	0	0	1.15
pVTA	mRNA stability	0	0	1.2
RMTg	alternative polyA	1	0.2	1.24
RMTg	alternative TSS	0	0	1.14
RMTg	gene expression	0	0	1.14
RMTg	isoform ratio	0	0	1.18
RMTg	intron excision ratio	0	0	1.22
RMTg	mRNA stability	0	0	1.13