Hub : Genes

Serpinh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Serpinh1 0.13 0.07 4.9e-13 0.1 0.1 0.1 0.1 5.2e-11 1.5e-11 2.3e-11 1.2e-10
2 Liver alternative TSS XM_039107102.2 0.09 0.05 4.1e-09 0.06 0.06 0.06 0.06 1.2e-07 1.5e-07 4.0e-07 3.2e-07
3 Liver alternative TSS XM_063285943.1 0.08 0.05 9.3e-09 0.06 0.06 0.06 0.06 2.6e-07 3.6e-07 9.3e-07 7.6e-07
4 Brain mRNA stability Serpinh1 0.08 0.06 2.8e-05 0.06 0.05 0.05 0.05 7.0e-06 2.5e-05 1.8e-05 1.2e-05
5 Adipose alternative TSS NM_017173.2 0.03 0.02 3.8e-03 0.02 0.02 0.02 0.02 9.3e-04 4.2e-03 1.9e-03 2.1e-03
6 Adipose alternative TSS XM_063285943.1 0.03 0.02 1.5e-03 0.03 0.02 0.03 0.03 4.0e-04 1.3e-03 8.2e-04 5.9e-04
7 Liver mRNA stability Serpinh1 0.05 0.03 1.1e-04 0.03 0.03 0.02 0.03 2.2e-04 4.8e-04 9.0e-04 8.4e-04
8 Adipose alternative TSS XM_039107102.2 0.05 0.03 5.9e-05 0.04 0.04 0.03 0.04 1.6e-05 6.5e-05 3.0e-04 3.8e-05
9 Adipose alternative TSS XM_063285943.1 0.05 0.04 1.1e-04 0.04 0.03 0.02 0.03 5.6e-05 2.3e-04 9.9e-04 9.5e-05
10 Adipose isoform ratio NM_017173.2 0.09 0.05 1.3e-08 0.06 0.06 0.05 0.06 1.2e-07 7.1e-07 1.1e-06 4.4e-07
11 Adipose isoform ratio XM_063285943.1 0.08 0.05 6.2e-08 0.06 0.05 0.04 0.05 3.6e-07 2.4e-06 8.0e-06 1.5e-06
12 Liver gene expression Serpinh1 0.8 0.09 0.0e+00 0.56 0.6 0.6 0.59 6.6e-75 2.0e-82 1.6e-83 1.7e-81
13 Adipose intron excision ratio chr1_163059338_163061672 0.03 0.03 1.5e-03 0.02 0.02 0.02 0.02 1.6e-03 5.2e-03 2.7e-03 3.7e-03
14 Adipose intron excision ratio chr1_163059338_163062875 0.03 0.02 2.4e-03 0.02 0.02 0.02 0.02 9.4e-04 4.7e-03 2.0e-03 1.4e-03
15 Adipose gene expression Serpinh1 0.54 0.17 1.5e-11 0.08 0.12 0.13 0.08 3.4e-09 4.9e-13 1.6e-14 4.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.33.20.20.7-0.7-0.00.1-0.1-0.1-0.00.00.0-0.0-0.40.6-0.6-1.8
Area under the delay curve0.10.10.4-0.1-0.30.3-0.10.1-0.1-0.10.1-0.1-0.10.10.3-0.60.60.4
BMI with tail0.00.20.4-0.1-0.60.6-0.60.3-0.3-0.30.5-0.5-0.30.30.0-0.30.30.1
BMI without tail0.42.03.80.9-1.41.4-1.51.4-1.4-1.41.5-1.5-1.31.3-1.2-1.31.3-2.0
Body weight0.21.01.60.5-1.31.3-1.20.9-0.9-0.91.0-1.0-0.90.9-0.5-1.21.2-0.8
Weight adjusted by age0.20.71.90.5-0.70.7-0.70.7-0.7-0.70.8-0.8-0.60.6-0.4-1.41.4-1.0
Bone surface1.93.710.52.0-1.31.3-2.01.9-1.9-1.92.0-2.0-1.81.8-2.1-1.31.3-3.2
Bone volume1.02.08.11.4-0.80.8-1.31.4-1.4-1.41.3-1.3-1.31.3-1.6-0.80.8-2.9
Breakpoint value in progressive ratio session0.81.52.3-1.21.1-1.11.3-1.21.21.2-1.21.21.2-1.21.41.0-1.01.5
Number of licking bursts1.95.77.3-2.62.4-2.42.2-2.32.32.3-2.32.32.3-2.32.32.7-2.72.2
Context. condit. distance diff. score2.63.24.22.0-1.41.4-2.01.9-1.9-1.91.9-1.9-1.81.8-1.7-1.61.6-1.8
Locomotion velocity, session 10.80.92.1-0.80.6-0.61.4-0.90.90.9-1.11.11.0-1.00.80.9-0.91.1
Locomotion distance, session 10.20.20.80.5-0.90.9-0.10.2-0.2-0.20.1-0.1-0.10.1-0.3-0.70.70.6
Locomotion velocity, session 20.00.10.2-0.1-0.50.50.40.1-0.1-0.10.1-0.1-0.10.1-0.1-0.10.10.3
Locomotion distance, session 20.20.30.80.6-0.90.9-0.00.5-0.5-0.50.4-0.4-0.50.5-0.6-0.60.6-0.2
Locomotion velocity, session 30.10.20.40.6-0.60.6-0.40.3-0.3-0.30.3-0.3-0.30.3-0.4-0.50.50.2
Locomotion distance, session 30.20.20.60.8-0.70.7-0.40.5-0.5-0.50.4-0.4-0.50.5-0.7-0.20.20.2
Stereotopy head waving bouts, day 30.20.20.4-0.60.4-0.40.4-0.40.40.4-0.50.50.4-0.40.40.4-0.40.4
Stereotopy head waving duration, day 30.20.30.50.6-0.30.3-0.60.5-0.5-0.50.5-0.5-0.60.6-0.6-0.70.7-0.7
Locomotion velocity, session 70.40.40.8-0.50.6-0.60.5-0.70.70.7-0.60.60.7-0.70.70.6-0.60.9
Locomotion distance, session 70.10.10.3-0.30.4-0.40.2-0.30.30.3-0.20.20.3-0.30.40.5-0.50.6
Stereotopy head waving bouts, day 71.61.92.21.5-1.51.5-1.31.4-1.4-1.41.3-1.3-1.41.4-1.4-1.41.4-1.0
Stereotopy head waving duration, day 72.73.43.91.9-1.91.9-1.81.8-1.8-1.81.7-1.7-1.81.8-1.8-2.02.0-1.8
Locomotion velocity, session 81.61.92.61.6-1.01.0-1.31.6-1.6-1.61.4-1.4-1.51.5-1.5-1.01.0-1.6
Locomotion distance, session 81.82.63.31.8-1.81.8-1.51.6-1.6-1.61.6-1.6-1.61.6-1.6-1.71.7-1.1
Degree of sensitization distance0.00.00.1-0.40.2-0.2-0.2-0.00.00.00.2-0.20.1-0.10.3-0.10.1-0.3
Degree of sensitization stereotypy3.64.05.32.1-2.32.3-1.82.0-2.0-2.01.9-1.9-2.02.0-2.0-2.12.1-1.4
Conditioned locomotion0.20.20.3-0.20.4-0.40.4-0.50.50.5-0.50.50.4-0.40.30.6-0.60.3
Cocaine response after cond. corrected1.92.85.5-1.81.3-1.31.3-1.81.81.8-1.51.51.8-1.81.91.5-1.52.3
Cocaine response after cond. not corrected1.11.54.7-1.20.7-0.70.9-1.31.31.3-1.11.11.3-1.31.41.1-1.12.2
Cocaine response before conditioning1.01.22.21.4-1.11.1-0.81.2-1.2-1.20.9-0.9-1.21.2-1.5-0.70.7-0.9
Saline control response1.62.24.41.4-1.71.7-1.41.3-1.3-1.31.3-1.3-1.31.3-1.3-2.12.1-1.2
Bone: connectivity density0.40.74.30.90.2-0.2-0.70.7-0.7-0.70.7-0.7-0.60.6-1.00.1-0.1-2.1
Bone: cortical apparent density1.01.62.4-1.41.3-1.31.3-1.21.21.2-1.31.31.1-1.11.01.6-1.60.8
Bone: cortical area0.50.81.50.9-0.60.6-1.20.9-0.9-0.91.1-1.1-0.80.8-0.9-0.40.4-1.2
Bone: cortical porosity0.10.10.30.5-0.60.6-0.30.3-0.3-0.30.2-0.2-0.30.3-0.2-0.50.50.4
Bone: cortical porosity0.10.20.40.5-0.60.6-0.20.4-0.4-0.40.2-0.2-0.40.4-0.4-0.50.50.2
Bone: cortical thickness0.30.50.9-0.60.9-0.90.5-0.80.80.8-0.50.50.8-0.80.60.9-0.90.1
Bone: cortical thickness0.10.10.40.2-0.30.3-0.2-0.10.10.1-0.10.10.1-0.1-0.20.3-0.30.7
Bone: cortical tissue density1.01.72.5-1.41.3-1.31.4-1.21.21.2-1.31.31.2-1.21.11.6-1.60.9
Condit. Reinf. active minus inactive responses0.60.72.10.7-0.70.7-0.70.7-0.7-0.70.8-0.8-0.70.7-0.8-0.90.9-1.5
Condit. Reinf. active-inactive response ratio1.61.74.21.2-1.01.0-1.41.3-1.3-1.31.4-1.4-1.31.3-1.3-1.11.1-2.0
Condit. Reinf. active responses0.10.10.60.1-0.30.3-0.00.2-0.2-0.20.2-0.2-0.20.2-0.3-0.60.6-0.8
Condit. Reinf. inactive responses0.20.20.6-0.50.1-0.10.8-0.50.50.5-0.60.60.5-0.50.40.0-0.00.6
Incentive salience index mean0.60.82.00.7-0.80.8-0.60.8-0.8-0.80.7-0.7-0.80.8-0.8-1.21.2-1.4
Condit. Reinf. lever presses0.40.61.10.6-0.80.8-0.40.7-0.7-0.70.5-0.5-0.80.8-0.8-1.01.0-0.9
Condit. Reinf. active minus inactive responses6.39.714.73.0-3.63.6-3.13.0-3.0-3.02.9-2.9-2.92.9-2.7-3.83.8-2.0
Condit. Reinf. active-inactive response ratio0.71.23.01.0-1.51.5-1.00.8-0.8-0.80.7-0.7-0.80.8-0.7-1.71.7-0.1
Condit. Reinf. active responses10.815.420.03.8-4.44.4-3.93.8-3.8-3.83.8-3.8-3.83.8-3.6-4.54.5-2.9
Condit. Reinf. inactive responses6.29.29.82.9-3.13.1-2.93.1-3.1-3.13.0-3.0-3.13.1-3.0-3.13.1-2.8
Condit. Reinf. lever presses19.327.931.05.5-5.55.5-5.65.2-5.2-5.25.3-5.3-5.35.3-5.0-5.65.6-3.9
Condit. Reinf. lever reinforcers received12.217.021.94.0-4.64.6-4.14.1-4.1-4.14.0-4.0-4.04.0-3.8-4.74.7-2.9
Conditioned reinforcement - actives0.31.21.51.2-1.01.0-1.11.1-1.1-1.11.1-1.1-1.11.1-1.1-1.11.1-1.2
Conditioned reinforcement - inactives0.30.91.5-1.01.0-1.00.9-0.90.90.9-0.90.90.9-0.91.10.4-0.41.2
Conditioned locomotion0.20.30.90.9-0.60.6-0.50.5-0.5-0.50.5-0.5-0.50.5-0.6-0.80.8-0.0
Patch foraging indifference point 0 sec3.49.611.63.3-3.03.0-3.43.2-3.2-3.23.2-3.2-3.13.1-3.0-2.92.9-2.4
Patch foraging indifference point AUC0.20.51.00.5-0.80.8-0.70.6-0.6-0.60.8-0.8-0.70.7-0.6-0.80.8-1.0
Delay disc. indifference point, 0s delay1.01.12.10.9-1.41.4-0.90.9-0.9-0.90.9-0.9-0.90.9-0.9-1.41.4-0.1
Delay disc. indifference point, 16s delay0.10.10.4-0.40.3-0.30.3-0.30.30.3-0.30.30.3-0.30.50.2-0.20.6
Delay disc. indifference point, 2s delay1.01.12.30.6-1.41.4-1.01.0-1.0-1.01.0-1.0-1.01.0-0.4-1.51.50.7
Delay disc. indifference point, 24s delay0.50.91.4-1.01.2-1.20.9-0.90.90.9-0.90.90.9-0.90.90.8-0.8-0.6
Delay disc. indifference point, 4s delay0.90.93.60.4-1.61.6-0.50.5-0.5-0.50.5-0.5-0.50.5-0.3-1.91.90.2
Delay disc. indifference point, 8s delay0.20.40.60.5-0.50.5-0.60.6-0.6-0.60.6-0.6-0.60.6-0.3-0.80.8-0.5
Indifference point function ln k0.20.61.41.2-0.60.6-0.80.8-0.8-0.80.7-0.7-0.80.8-0.9-0.70.7-0.3
Indifference point function log k0.20.61.41.2-0.60.6-0.80.8-0.8-0.80.7-0.7-0.80.8-0.9-0.70.7-0.3
Patch foraging total patch changes 0 sec2.78.09.83.0-2.82.8-3.12.9-2.9-2.92.9-2.9-2.82.8-2.7-2.72.7-2.1
Patch foraging total patch changes 12 sec3.04.04.81.8-2.12.1-2.02.0-2.0-2.02.2-2.2-1.91.9-1.9-1.81.8-2.1
Patch foraging total patch changes 18 sec2.45.66.72.3-2.42.4-2.32.5-2.5-2.52.6-2.6-2.42.4-2.5-1.91.9-2.4
Patch foraging total patch changes 24 sec0.30.92.00.7-1.41.4-0.71.0-1.0-1.01.0-1.0-0.90.9-0.6-1.01.0-0.3
Patch foraging total patch changes 6 sec1.52.63.31.7-1.41.4-1.81.5-1.5-1.51.7-1.7-1.51.5-1.4-1.71.7-1.8
Patch foraging time to switch 0 sec2.07.58.6-2.92.8-2.82.9-2.72.72.7-2.62.62.8-2.82.82.8-2.82.1
Patch foraging water rate 0 sec1.45.46.52.5-2.52.5-2.52.3-2.3-2.32.4-2.4-2.42.4-2.4-2.12.1-1.2
Patch foraging water rate 12 sec0.62.53.21.8-1.51.5-1.51.6-1.6-1.61.5-1.5-1.61.6-1.7-1.61.6-1.3
Patch foraging water rate 18 sec0.40.91.31.1-1.11.1-1.00.9-0.9-0.90.9-0.9-0.90.9-1.1-1.01.0-0.6
Patch foraging water rate 24 sec0.40.51.11.1-0.70.7-0.60.7-0.7-0.70.8-0.8-0.70.7-0.9-0.70.7-0.3
Patch foraging water rate 6 sec0.30.51.01.0-0.60.6-0.80.8-0.8-0.80.7-0.7-0.80.8-0.9-0.40.4-0.1
Seeking ratio, delayed vs. immediate footshock2.13.03.7-1.61.6-1.61.9-1.91.91.9-1.81.81.7-1.71.41.9-1.91.0
Distance traveled before self-admin0.20.30.6-0.70.8-0.80.5-0.50.50.5-0.60.60.5-0.50.80.1-0.1-0.4
Distance traveled after self-admin1.42.53.3-1.41.6-1.61.8-1.81.81.8-1.81.81.8-1.81.61.0-1.01.0
Extensor digitorum longus weight0.10.42.60.2-0.20.2-0.70.5-0.5-0.50.7-0.7-0.50.5-0.4-0.60.6-1.6
Bone: elastic displacement2.02.53.2-1.41.8-1.81.3-1.61.61.6-1.41.41.6-1.61.61.8-1.81.3
Bone: elastic work2.12.73.7-1.51.9-1.91.5-1.71.71.7-1.51.51.7-1.71.61.9-1.91.0
Bone: endosteal estimation1.94.75.22.0-2.12.1-2.22.3-2.3-2.32.2-2.2-2.22.2-2.1-1.91.9-2.3
Bone: endosteal perimeter2.76.67.52.4-2.52.5-2.62.7-2.7-2.72.5-2.5-2.62.6-2.5-2.42.4-2.5
Epididymis fat weight0.20.91.8-1.20.6-0.60.9-1.01.01.0-1.01.00.9-0.91.40.5-0.51.0
Delta time in closed arm before/after self-admin0.20.20.7-0.80.7-0.70.3-0.30.30.3-0.40.40.3-0.30.7-0.00.0-0.4
Delta time in open arm before/after self-admin2.42.83.91.9-1.81.8-1.81.8-1.8-1.81.8-1.8-1.81.8-2.0-1.01.0-0.9
Diff in mean of infusions in LGA sessions4.37.89.6-3.12.6-2.63.0-2.92.92.9-2.92.92.9-2.93.12.4-2.42.0
Delay discount exponential model param0.10.10.40.20.3-0.30.0-0.00.00.0-0.00.00.0-0.0-0.30.6-0.6-0.4
Extinction: sum of active levers before priming0.00.00.1-0.1-0.00.00.00.1-0.1-0.10.1-0.1-0.10.10.2-0.30.30.1
Active lever presses in extinction session 60.30.30.70.8-0.50.5-0.40.4-0.4-0.40.4-0.4-0.40.4-0.4-0.60.60.8
Bone: final force0.10.10.50.10.3-0.3-0.3-0.10.10.10.1-0.10.1-0.10.00.7-0.7-0.3
Bone: final moment0.10.10.50.40.1-0.1-0.50.1-0.1-0.10.4-0.4-0.20.2-0.30.4-0.4-0.7
Food consumed during 24 hour testing period1.93.86.12.1-2.12.1-1.41.8-1.8-1.81.6-1.6-1.91.9-2.3-2.02.0-2.5
Glucose0.00.10.2-0.20.2-0.20.2-0.20.20.2-0.40.40.2-0.20.30.2-0.20.3
Heart weight0.71.11.61.2-1.01.0-1.21.0-1.0-1.01.1-1.1-1.01.0-1.0-1.01.0-1.3
Delay discount hyperbolic model param0.10.10.60.00.5-0.50.2-0.20.20.2-0.20.20.2-0.2-0.10.8-0.8-0.3
Intermittent access intake day 1-15 change0.20.91.41.2-0.80.8-1.01.1-1.1-1.11.1-1.1-1.11.1-1.1-0.50.5-0.1
Intermittent access intake escalation0.21.11.71.3-0.90.9-1.11.2-1.2-1.21.2-1.2-1.21.2-1.2-0.70.7-0.3
Intermittent access intake escalation 20.61.01.41.2-1.01.0-1.11.1-1.1-1.11.1-1.1-1.11.1-1.2-0.50.5-0.0
Intermitt. access day 1 inactive lever presses0.33.65.3-2.01.6-1.61.9-2.02.02.0-2.02.02.0-2.02.01.6-1.62.3
Intermitt. access day 15 inactive lever presses0.52.63.2-1.61.5-1.51.7-1.81.81.8-1.81.81.8-1.81.61.2-1.21.2
Intermitt. access escalation Index0.00.00.40.10.2-0.2-0.10.0-0.0-0.00.0-0.0-0.00.0-0.0-0.20.2-0.6
Intermittent access day 1 total infusions0.30.92.31.0-0.80.8-0.90.8-0.8-0.80.8-0.8-0.80.8-0.9-1.21.2-1.5
Intermittent access day 15 total infusions0.61.42.11.4-1.01.0-1.21.2-1.2-1.21.2-1.2-1.21.2-1.3-1.01.0-1.0
Intermittent access terminal intake (last 3 days)1.32.23.11.7-1.31.3-1.61.6-1.6-1.61.6-1.6-1.61.6-1.7-1.21.2-1.3
Intermittent access total infusions1.41.62.11.4-1.11.1-1.41.3-1.3-1.31.3-1.3-1.31.3-1.5-0.90.9-1.2
Intermittent access day 1 locomotion0.00.10.40.5-0.00.0-0.30.2-0.2-0.20.2-0.2-0.20.2-0.4-0.10.1-0.7
Intermittent access day 15 total locomotion0.20.81.41.2-0.70.7-0.91.0-1.0-1.01.0-1.0-1.01.0-1.1-0.60.6-0.6
Intermittent access total locomotion0.50.71.01.0-0.60.6-0.90.9-0.9-0.90.9-0.9-0.90.9-0.9-0.50.5-0.9
Intermittent access standard deviation0.10.50.60.6-0.80.8-0.70.8-0.8-0.80.8-0.8-0.80.8-0.8-0.60.6-0.5
Left kidney weight0.21.42.50.7-1.41.4-1.01.1-1.1-1.11.0-1.0-1.11.1-0.9-1.61.6-1.5
Right kidney weight0.21.72.70.9-1.61.6-1.31.3-1.3-1.31.3-1.3-1.31.3-1.2-1.21.2-1.3
Cocaine induced anxiety0.41.22.3-1.01.4-1.41.0-1.01.01.0-1.01.01.0-1.00.91.5-1.50.4
Post-drug Anxiety1.11.32.2-1.21.5-1.51.1-1.11.11.1-1.11.11.1-1.11.11.2-1.20.3
Baseline Anxiety0.20.30.70.4-0.40.4-0.50.5-0.5-0.50.5-0.5-0.50.5-0.3-0.80.8-0.4
Tail length0.73.88.91.4-1.81.8-1.81.9-1.9-1.91.8-1.8-1.81.8-1.8-2.22.2-3.0
Length with tail0.41.92.81.0-1.51.5-1.41.3-1.3-1.31.3-1.3-1.31.3-1.1-1.71.7-1.6
Length without tail0.20.83.3-0.90.3-0.30.8-0.90.90.9-1.01.00.8-0.80.90.6-0.61.8
Times rat made contact with spout0.10.10.3-0.20.1-0.10.10.0-0.0-0.0-0.20.2-0.00.0-0.20.6-0.6-0.3
Lifetime Intake1.41.72.11.5-1.21.2-1.41.4-1.4-1.41.4-1.4-1.41.4-1.4-0.90.9-1.0
Liver weight, left0.00.10.5-0.3-0.20.20.0-0.00.00.0-0.00.00.0-0.00.10.3-0.30.7
Liver weight, right0.50.91.6-1.30.5-0.51.0-1.01.01.0-0.90.91.0-1.00.81.2-1.20.7
Locomotor activity1.21.83.61.6-1.21.2-1.41.3-1.3-1.31.0-1.0-1.31.3-1.7-1.11.1-1.9
Locomotor testing distance1.74.25.52.1-2.22.2-2.02.1-2.1-2.11.8-1.8-2.12.1-2.3-1.91.9-2.2
Locomotor testing rearing0.51.72.61.2-1.61.6-1.21.5-1.5-1.51.3-1.3-1.51.5-1.6-0.60.6-0.7
Locomotion in novel chamber0.40.51.21.0-0.50.5-0.60.5-0.5-0.50.6-0.6-0.60.6-0.9-1.01.0-1.1
Locomotion in novel chamber post-restriction0.61.92.61.6-1.41.4-1.51.5-1.5-1.51.5-1.5-1.51.5-1.3-0.90.90.6
Fecal boli incidents, locomotor time 10.10.30.70.8-0.70.7-0.40.3-0.3-0.30.3-0.3-0.30.3-0.8-0.50.5-0.6
Change in fecal boli incidents, locomotor task0.80.81.6-1.11.0-1.00.9-0.90.90.9-0.80.80.9-0.91.30.7-0.70.8
Time >=10cm from walls, locomotor time 10.91.12.11.2-1.11.1-1.11.0-1.0-1.01.0-1.0-1.01.0-0.8-1.41.4-0.3
Bouts of movement, locomotor time 10.20.31.90.1-0.30.30.0-0.10.10.1-0.00.00.1-0.10.2-1.41.4-0.4
Total resting periods, locomotor time 10.20.20.8-0.10.1-0.10.4-0.40.40.4-0.30.30.4-0.40.4-0.90.9-0.4
Rest time, locomotor task time 10.61.01.3-0.80.6-0.61.0-1.11.11.1-1.11.11.1-1.11.1-0.80.8-0.7
Distance moved, locomotor task time 10.41.21.80.9-0.60.6-1.31.3-1.3-1.31.3-1.3-1.31.3-1.30.8-0.8-0.0
Vertical activity count, locomotor time 10.31.92.91.3-0.90.9-1.71.7-1.7-1.71.7-1.7-1.71.7-1.60.2-0.2-0.3
Time >=10cm from walls, locomotor time 20.41.12.90.9-1.41.4-0.90.8-0.8-0.80.8-0.8-0.80.8-0.8-1.71.7-0.6
Bouts of movement, locomotor time 20.20.71.50.6-1.01.0-0.70.8-0.8-0.80.9-0.9-0.80.8-0.5-1.21.2-0.0
Total resting periods, locomotor time 20.10.30.80.2-0.70.7-0.40.5-0.5-0.50.5-0.5-0.50.5-0.1-0.90.90.4
Rest time, locomotor task time 21.62.63.5-1.71.9-1.91.6-1.71.71.7-1.71.71.7-1.71.71.5-1.50.3
Distance moved, locomotor task time 22.33.04.41.8-2.12.1-1.81.8-1.8-1.81.9-1.9-1.81.8-1.8-1.31.3-0.3
Vertical activity count, locomotor time 21.22.73.71.6-1.61.6-1.71.8-1.8-1.81.9-1.9-1.81.8-1.7-1.11.1-0.9
Light reinforcement 10.52.12.8-1.71.4-1.41.4-1.51.51.5-1.51.51.5-1.51.51.3-1.30.7
Light reinforcement 20.10.20.4-0.30.4-0.40.4-0.60.60.6-0.50.50.6-0.60.4-0.30.3-0.3
Bone: marrow area1.74.14.71.8-1.91.9-2.12.1-2.1-2.12.1-2.1-2.12.1-2.0-1.81.8-2.2
Bone: maximum diameter2.75.46.62.3-2.12.1-2.62.4-2.4-2.42.5-2.5-2.32.3-2.2-2.12.1-2.5
Bone: maximum force0.10.20.60.50.1-0.1-0.70.4-0.4-0.40.6-0.6-0.30.3-0.40.3-0.3-0.8
Bone: maximum moment0.20.41.50.7-0.20.2-0.90.6-0.6-0.60.8-0.8-0.60.6-0.60.0-0.0-1.2
Mean time between licks in bursts1.16.79.42.3-3.13.1-2.42.5-2.5-2.52.5-2.5-2.52.5-2.5-2.82.8-2.0
Mean num. licks in bursts2.05.46.62.6-2.32.3-2.22.3-2.3-2.32.2-2.2-2.32.3-2.4-2.42.4-2.2
Cd content in liver0.10.10.3-0.50.3-0.30.2-0.30.30.3-0.20.20.3-0.30.40.2-0.20.4
Co content in liver1.41.72.21.2-1.51.5-1.11.4-1.4-1.41.3-1.3-1.41.4-1.4-1.01.0-0.6
Cu content in liver0.40.51.50.2-1.21.2-0.20.5-0.5-0.50.3-0.3-0.50.5-0.5-1.21.2-0.1
Fe content in liver0.10.20.5-0.30.3-0.30.1-0.40.40.4-0.40.40.4-0.40.50.3-0.30.7
K content in liver0.00.00.1-0.3-0.10.10.40.0-0.0-0.0-0.10.1-0.00.00.0-0.20.2-0.0
Mg content in liver0.10.10.40.1-0.50.5-0.00.2-0.2-0.20.1-0.1-0.20.2-0.2-0.10.10.6
Mn content in liver2.02.33.0-1.31.3-1.31.5-1.51.51.5-1.51.51.5-1.51.41.7-1.71.6
Na content in liver0.30.30.80.5-0.80.8-0.50.6-0.6-0.60.3-0.3-0.60.6-0.5-0.30.30.9
Rb content in liver0.81.01.71.1-0.80.8-0.91.1-1.1-1.10.9-0.9-1.11.1-1.3-0.50.5-1.2
Se content in liver7.99.311.1-3.22.8-2.83.3-3.33.33.3-3.23.23.3-3.33.22.4-2.42.2
Sr content in liver0.10.10.30.3-0.10.1-0.20.1-0.1-0.10.3-0.3-0.10.1-0.30.5-0.50.4
Zn content in liver3.23.85.31.8-2.32.3-1.71.9-1.9-1.91.8-1.8-1.91.9-1.9-2.22.2-1.5
Bone: minimum diameter0.91.72.91.0-1.21.2-1.41.4-1.4-1.41.4-1.4-1.31.3-1.3-1.11.1-1.7
Time in familiar zone, hab. session 10.00.00.1-0.10.1-0.10.20.2-0.2-0.20.0-0.0-0.10.1-0.10.3-0.3-0.0
Time in novel zone, hab. session 10.10.10.2-0.30.3-0.30.0-0.40.40.4-0.20.20.3-0.30.40.1-0.10.1
Total zone transitions, hab. session 10.00.00.20.30.1-0.1-0.00.1-0.1-0.10.1-0.1-0.00.0-0.2-0.00.0-0.4
Total locomotion distance, hab. session 10.30.40.7-0.80.3-0.30.6-0.60.60.6-0.60.60.6-0.60.50.7-0.70.8
Locomotion velocity, hab. session 10.10.20.3-0.60.2-0.20.4-0.40.40.4-0.40.40.4-0.40.30.5-0.50.6
Time in familiar zone, hab. session 22.63.05.61.7-1.31.3-1.71.8-1.8-1.81.8-1.8-1.91.9-1.9-1.31.3-2.4
Time in novel zone, hab. session 21.51.74.6-1.20.6-0.61.2-1.41.41.4-1.31.31.4-1.41.30.9-0.92.1
Total zone transitions, hab. session 20.70.91.81.1-1.21.2-0.70.8-0.8-0.80.9-0.9-0.70.7-0.8-1.31.3-0.5
Total locomotion distance, hab. session 20.10.10.6-0.1-0.60.6-0.00.1-0.1-0.10.1-0.1-0.10.1-0.1-0.80.8-0.3
Locomotion velocity, hab. session 20.10.10.3-0.3-0.60.60.1-0.10.10.1-0.00.00.1-0.10.1-0.60.60.1
Novel to familiar place preference ratio0.10.10.6-0.1-0.10.1-0.1-0.10.10.1-0.00.00.2-0.20.3-0.30.30.8
Novelty place preference0.10.10.8-0.2-0.10.1-0.0-0.20.20.2-0.20.20.3-0.30.4-0.20.20.9
Time in novel zone, NPP test0.10.10.40.0-0.30.3-0.2-0.00.00.00.1-0.10.1-0.10.2-0.40.40.6
Total zone transitions, NPP test0.00.10.20.1-0.20.20.4-0.20.20.2-0.20.20.2-0.20.1-0.30.30.4
Total locomotion distance, NPP test0.81.11.6-1.30.2-0.21.2-1.31.31.3-1.11.11.3-1.31.20.1-0.11.2
Locomotion velocity, NPP test1.42.02.8-1.70.5-0.51.6-1.61.61.6-1.51.51.7-1.71.60.5-0.51.7
Intraocular pressure0.10.10.40.5-0.20.2-0.30.4-0.4-0.40.4-0.4-0.40.4-0.40.1-0.10.6
Delta distance traveled before/after self-admin0.00.00.20.4-0.30.30.10.0-0.0-0.0-0.00.0-0.00.0-0.3-0.40.40.2
Delta ambulatory time before/after self-admin0.00.10.30.3-0.20.20.2-0.00.00.0-0.10.10.0-0.0-0.2-0.50.50.5
Parametrial fat weight0.30.61.4-1.00.9-0.90.6-0.80.80.8-0.70.70.8-0.81.20.4-0.40.4
Pavlov. Cond. lever latency2.22.84.1-1.71.7-1.71.4-1.71.71.7-1.51.51.8-1.82.01.4-1.41.9
Pavlov. Cond. magazine entry latency4.35.56.92.5-2.42.4-2.52.4-2.4-2.42.3-2.3-2.52.5-2.6-2.02.0-2.0
Pavlov. Cond. change in total contacts1.21.32.11.1-1.51.5-1.01.0-1.0-1.00.9-0.9-1.11.1-1.2-1.31.3-1.0
Pavlov. Cond. index score4.15.27.02.3-2.32.3-2.12.4-2.4-2.42.1-2.1-2.42.4-2.6-2.02.0-2.3
Pavlov. Cond. latency score3.95.06.82.3-2.32.3-2.12.3-2.3-2.32.0-2.0-2.42.4-2.6-1.91.9-2.1
Pavlov. Cond. lever contacts2.22.64.11.6-1.61.6-1.31.6-1.6-1.61.4-1.4-1.71.7-1.9-1.51.5-2.0
Pavlov. Cond. magazine entry number4.45.66.9-2.52.5-2.52.4-2.42.42.4-2.22.22.5-2.52.62.2-2.22.2
Pavlov. Cond. intertrial magazine entries2.42.84.0-1.81.4-1.42.0-1.91.91.9-1.71.71.9-1.91.81.2-1.21.0
Pavlov. Cond. lever-magazine prob. diff.3.44.25.72.1-2.02.0-1.92.1-2.1-2.11.9-1.9-2.22.2-2.4-1.71.7-2.2
Pavlov. Cond. response bias2.32.94.71.6-1.71.7-1.41.7-1.7-1.71.4-1.4-1.71.7-1.9-1.61.6-2.2
Pavlov. Cond. lever latency20.729.134.2-5.65.7-5.75.6-5.35.35.3-5.55.55.3-5.35.15.8-5.83.7
Pavlov. Cond. magazine entry latency4.25.97.72.8-2.42.4-2.82.5-2.5-2.52.8-2.8-2.52.5-2.5-1.91.9-1.2
Pavlov. Cond. change in total contacts7.518.423.64.5-4.94.9-4.54.1-4.1-4.14.3-4.3-4.14.1-4.0-4.84.8-2.4
Pavlov. Cond. index score13.320.924.04.9-4.84.8-4.94.5-4.5-4.54.8-4.8-4.54.5-4.4-4.74.7-2.7
Pavlov. Cond. latency score11.318.120.84.5-4.54.5-4.64.2-4.2-4.24.5-4.5-4.24.2-4.1-4.34.3-2.4
Pavlov. Cond. lever contacts19.028.033.65.5-5.55.5-5.55.2-5.2-5.25.4-5.4-5.25.2-4.9-5.85.8-3.6
Pavlov. Cond. magazine entry number6.88.810.8-3.33.2-3.23.2-2.92.92.9-3.23.22.9-2.92.93.0-3.01.5
Pavlov. Cond. intertrial magazine entries0.10.20.60.1-0.40.4-0.30.4-0.4-0.40.2-0.2-0.40.4-0.4-0.60.6-0.8
Pavlov. Cond. lever-magazine prob. diff.12.619.422.34.6-4.74.7-4.74.4-4.4-4.44.6-4.6-4.34.3-4.2-4.54.5-2.5
Pavlov. Cond. response bias20.828.832.25.7-5.65.6-5.65.3-5.3-5.35.5-5.5-5.35.3-5.1-5.75.7-3.7
Time in closed arm before self-admin0.30.51.21.1-0.80.8-0.60.5-0.5-0.50.5-0.5-0.50.5-1.0-0.70.7-1.0
Time in closed arm after self-admin1.01.21.7-1.01.3-1.31.2-1.21.21.2-1.21.21.2-1.21.00.6-0.6-0.4
Time in open arm before self-admin1.92.34.1-1.91.6-1.61.7-1.51.51.5-1.61.61.5-1.52.00.8-0.81.3
Time in open arm after self-admin0.91.01.40.8-0.90.9-1.11.2-1.2-1.21.1-1.1-1.21.2-0.9-0.50.50.1
Bone: periosteal estimation1.53.54.51.8-1.81.8-2.12.0-2.0-2.02.1-2.1-1.91.9-1.9-1.41.4-2.0
Bone: periosteal perimeter2.34.66.32.0-1.81.8-2.22.3-2.3-2.32.1-2.1-2.22.2-2.2-2.02.0-2.5
Bone: post-yield work0.50.93.40.9-0.30.3-1.11.0-1.0-1.01.0-1.0-1.01.0-1.0-0.40.4-1.9
Progressive ratio test 1 active lever presses0.20.30.5-0.50.7-0.70.5-0.50.50.5-0.50.50.5-0.50.50.6-0.60.1
Progressive ratio test 1 breakpoint0.20.30.6-0.50.7-0.70.5-0.50.50.5-0.50.50.5-0.50.50.6-0.60.0
Progressive ratio test 1 inactive lever presses0.20.50.8-0.60.9-0.90.6-0.60.60.6-0.60.60.6-0.60.70.8-0.80.5
Progressive ratio test 2 active lever presses0.50.70.90.7-0.60.6-0.80.9-0.9-0.90.9-0.9-0.90.9-0.7-0.70.7-0.9
Progressive ratio test 2 breakpoint0.50.70.90.8-0.60.6-0.80.9-0.9-0.90.9-0.9-0.90.9-0.7-0.70.7-1.0
Progressive ratio test 2 inactive lever presses0.10.30.70.5-0.20.2-0.60.5-0.5-0.50.5-0.5-0.50.5-0.4-0.60.6-0.8
Incentive Sensitization - Responses0.82.32.61.4-1.41.4-1.51.6-1.6-1.61.6-1.6-1.61.6-1.3-1.61.6-1.5
Incentive Sensitization - Breakpoint0.92.12.31.4-1.31.3-1.51.5-1.5-1.51.5-1.5-1.51.5-1.3-1.51.5-1.4
Sum of active levers in priming session hrs 5-60.00.00.1-0.0-0.30.30.1-0.20.20.2-0.10.10.2-0.20.1-0.40.4-0.0
Progressive ratio0.10.20.40.6-0.50.5-0.40.3-0.3-0.30.4-0.4-0.30.3-0.70.3-0.30.3
Food seeking constrained by brief footshock2.02.53.11.5-1.81.8-1.71.6-1.6-1.61.6-1.6-1.61.6-1.6-1.51.5-0.9
Seeking ratio, punishment vs. effort0.51.01.40.7-1.01.0-1.01.1-1.1-1.11.0-1.0-1.11.1-0.8-1.21.2-0.7
Retroperitoneal fat weight0.41.94.6-2.11.4-1.41.0-1.31.31.3-1.31.31.3-1.31.81.3-1.30.9
Reaction time number correct0.00.10.20.10.1-0.10.3-0.20.20.2-0.40.40.2-0.20.0-0.30.3-0.0
Reaction time mean minus median0.21.62.31.4-1.11.1-1.51.4-1.4-1.41.3-1.3-1.41.4-1.4-0.90.9-0.5
Reaction time mean minus median AUC0.21.62.21.5-1.11.1-1.41.4-1.4-1.41.3-1.3-1.41.4-1.4-0.90.9-0.9
Reaction time num false alarms1.01.72.5-1.61.2-1.21.5-1.31.31.3-1.21.21.3-1.31.41.4-1.40.8
Reaction time num false alarms AUC0.51.11.8-1.30.9-0.91.3-1.11.11.1-1.01.01.1-1.11.21.1-1.10.7
Reaction time trials correct on left0.00.10.20.10.1-0.10.3-0.20.20.2-0.40.40.2-0.20.0-0.30.3-0.0
Reaction time trials on left0.00.10.20.10.1-0.10.3-0.20.20.2-0.40.40.2-0.20.0-0.30.30.0
Reaction time mean0.30.71.6-0.81.0-1.00.3-0.70.70.7-0.50.50.7-0.70.81.3-1.31.2
Reaction time mean AUC0.71.62.6-1.21.4-1.40.8-1.21.21.2-1.01.01.1-1.11.21.6-1.61.5
Median of all reaction times1.21.93.2-1.41.5-1.50.8-1.31.31.3-1.11.11.3-1.31.41.8-1.81.6
Reaction time omissions0.00.11.0-0.1-0.10.1-0.20.0-0.0-0.0-0.00.0-0.00.00.30.0-0.01.0
Reaction time false alarm rate1.01.32.1-1.41.0-1.01.2-1.11.11.1-0.90.91.1-1.11.31.5-1.51.0
Reaction time premature initiation rate2.53.85.61.9-1.71.7-2.42.1-2.1-2.12.3-2.3-2.12.1-2.0-1.31.3-1.4
Reaction time premature initiations1.03.14.21.9-1.51.5-2.11.9-1.9-1.92.0-2.0-1.81.8-1.9-1.31.3-1.3
Std. dev. reaction times0.20.61.10.7-0.50.5-1.00.9-0.9-0.90.9-0.9-1.01.0-0.8-0.20.20.1
Reaction time trials completed0.00.10.20.10.1-0.10.3-0.20.20.2-0.40.40.2-0.20.0-0.30.30.0
Reaction time trials AUC0.00.10.20.1-0.00.00.2-0.20.20.2-0.30.30.2-0.20.0-0.40.4-0.0
Run reversals in cocaine runway, females0.20.20.3-0.1-0.10.1-0.50.5-0.5-0.50.5-0.5-0.50.5-0.30.1-0.1-0.5
Run reversals in cocaine runway, males0.10.10.3-0.20.4-0.40.1-0.20.20.2-0.20.20.2-0.20.00.6-0.6-0.0
Latency to leave start box in cocaine runway2.73.78.9-2.31.6-1.61.7-1.81.81.8-1.71.71.8-1.82.31.9-1.93.0
Latency to leave start box in cocaine runway, F2.32.97.8-2.11.3-1.31.5-1.61.61.6-1.51.51.6-1.62.01.5-1.52.8
Latency to leave start box in cocaine runway, M0.70.71.2-0.80.8-0.80.7-0.70.70.7-0.70.70.8-0.80.90.9-0.91.1
Std. dev. time between licks in bursts1.12.13.11.1-1.81.8-1.31.6-1.6-1.61.4-1.4-1.61.6-1.4-1.31.3-0.8
Total sessions with >9 infusions1.72.22.81.6-1.51.5-1.61.6-1.6-1.61.6-1.6-1.61.6-1.7-0.60.6-0.4
Short access day 1 total inactive lever presses0.00.10.3-0.20.2-0.20.2-0.20.20.2-0.20.20.2-0.20.20.3-0.30.5
Short access day 10 total inactive lever presses0.21.62.0-1.31.3-1.31.3-1.41.41.4-1.41.41.4-1.41.30.8-0.80.7
Short access day 1 total infusions1.93.84.32.0-2.12.1-2.12.1-2.1-2.12.1-2.1-2.12.1-2.0-1.51.5-1.2
Short access day 10 total infusions0.81.31.71.2-1.31.3-1.21.2-1.2-1.21.2-1.2-1.21.2-1.2-0.90.9-0.6
Short access total infusions1.42.02.21.5-1.51.5-1.51.5-1.5-1.51.5-1.5-1.51.5-1.4-1.21.2-0.8
Short access day 1 locomotion1.32.13.01.7-1.51.5-1.61.6-1.6-1.61.6-1.6-1.61.6-1.6-0.80.8-0.3
Short access day 10 total locomotion0.41.72.41.6-1.41.4-1.31.4-1.4-1.41.4-1.4-1.41.4-1.6-0.80.8-0.5
Short access total locomotion0.40.60.91.0-0.70.7-0.80.8-0.8-0.80.8-0.8-0.80.8-1.00.1-0.10.1
One hour access (0.3 mA shock)1.11.31.91.4-1.11.1-1.21.2-1.2-1.21.2-1.2-1.21.2-1.4-0.60.6-0.9
Compulsive drug intake0.50.80.9-0.70.8-0.80.9-1.01.01.0-1.01.01.0-1.00.90.6-0.60.8
One hour access (shock baseline)0.71.72.61.5-1.31.3-1.41.4-1.4-1.41.4-1.4-1.41.4-1.6-0.80.8-0.8
Social response proportion0.50.71.2-0.80.7-0.70.7-0.80.80.8-0.70.70.9-0.90.61.1-1.10.8
Social responses0.30.30.9-0.70.2-0.20.5-0.50.50.5-0.50.50.5-0.50.40.9-0.90.8
Social time4.26.67.7-2.52.1-2.12.6-2.72.72.7-2.82.82.7-2.72.52.4-2.42.8
Soleus weight0.10.30.90.0-0.20.2-0.60.6-0.6-0.60.7-0.7-0.60.6-0.3-0.30.3-1.0
Bone: stiffness0.20.30.6-0.50.8-0.80.2-0.50.50.5-0.30.30.5-0.50.60.8-0.80.1
Tibialis anterior weight0.20.71.20.6-0.70.7-0.90.7-0.7-0.70.8-0.8-0.80.8-0.6-1.11.1-1.1
Time to tail flick, vehicle, before self-admin0.50.71.91.0-0.20.2-0.70.8-0.8-0.80.9-0.9-0.80.8-1.30.4-0.4-1.4
Time to tail flick, vehicle, after self-admin0.81.62.11.4-1.21.2-1.41.2-1.2-1.21.3-1.3-1.21.2-1.3-1.11.1-1.3
Time to tail flick, test, before self-admin0.60.60.80.6-0.60.6-0.80.9-0.9-0.90.8-0.8-0.90.9-0.8-0.90.9-0.7
Time to tail flick, test, after self-admin0.20.20.80.2-0.60.6-0.30.4-0.4-0.40.4-0.4-0.40.4-0.3-0.90.9-0.3
Delta time to tail flick, vehicle, before/after SA0.50.51.40.5-0.80.8-0.80.6-0.6-0.60.6-0.6-0.60.6-0.1-1.21.20.3
Delta time to tail flick, test, before/after SA0.60.71.0-0.90.6-0.60.9-0.90.90.9-0.90.90.9-0.91.00.5-0.50.8
Tibia length0.92.44.02.0-1.81.8-1.71.6-1.6-1.61.6-1.6-1.61.6-1.7-1.11.1-0.1
Ambulatory time before self-admin0.31.11.6-1.11.2-1.21.0-1.11.11.1-1.11.11.1-1.11.30.7-0.70.4
Ambulatory time after self-admin1.42.33.2-1.21.4-1.41.8-1.71.71.7-1.81.81.7-1.71.50.7-0.71.0
Bone: tissue strength0.60.71.1-0.51.1-1.10.6-0.80.80.8-0.70.70.8-0.80.90.8-0.80.6
Total heroin consumption0.00.00.1-0.1-0.20.20.3-0.00.00.0-0.20.20.0-0.00.1-0.40.4-0.0
Bone: trabecular number0.61.12.7-0.71.6-1.60.8-0.80.80.8-0.70.70.9-0.90.61.4-1.4-1.1
Bone: trabecular spacing0.40.61.60.7-1.11.1-0.60.6-0.6-0.60.6-0.6-0.70.7-0.4-1.21.20.5
Bone: trabecular thickness0.10.20.8-0.20.6-0.60.1-0.20.20.2-0.40.40.3-0.30.10.2-0.2-0.9
Bone: trabecular tissue density0.91.62.7-1.61.1-1.11.2-1.31.31.3-1.31.31.3-1.31.60.8-0.81.2
Water consumed over 24 hours0.30.60.9-0.70.9-0.91.0-0.60.60.6-0.90.90.7-0.70.51.0-1.0-0.2
Number of responses in last shaping day0.00.10.2-0.30.1-0.10.1-0.10.10.1-0.10.10.1-0.10.00.4-0.4-0.4