Hub : Genes

Serpinh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Serpinh1 0.13 0.07 4.9e-13 0.1 0.1 0.1 0.09 5.2e-11 1.5e-11 2.3e-11 1.3e-10
2 Liver alternative TSS XM_039107102.2 0.09 0.05 4.1e-09 0.06 0.06 0.06 0.06 1.2e-07 1.5e-07 4.0e-07 3.1e-07
3 Liver alternative TSS XM_063285943.1 0.08 0.05 9.3e-09 0.06 0.06 0.06 0.06 2.6e-07 3.6e-07 9.3e-07 7.2e-07
4 Brain mRNA stability Serpinh1 0.08 0.06 2.8e-05 0.06 0.05 0.05 0.05 7.0e-06 2.5e-05 1.8e-05 1.2e-05
5 Adipose alternative TSS NM_017173.2 0.03 0.02 3.8e-03 0.02 0.02 0.02 0.02 9.3e-04 4.2e-03 1.9e-03 2.1e-03
6 Adipose alternative TSS XM_063285943.1 0.03 0.02 1.5e-03 0.03 0.02 0.03 0.03 4.0e-04 1.3e-03 8.2e-04 5.8e-04
7 Liver mRNA stability Serpinh1 0.05 0.03 1.1e-04 0.03 0.03 0.02 0.03 2.2e-04 4.8e-04 9.0e-04 8.4e-04
8 Adipose alternative TSS XM_039107102.2 0.05 0.03 5.9e-05 0.04 0.04 0.03 0.04 1.6e-05 6.5e-05 3.0e-04 3.8e-05
9 Adipose alternative TSS XM_063285943.1 0.05 0.04 1.1e-04 0.04 0.03 0.02 0.03 5.6e-05 2.3e-04 9.9e-04 9.7e-05
10 Adipose isoform ratio NM_017173.2 0.09 0.05 1.3e-08 0.06 0.06 0.05 0.06 1.2e-07 7.1e-07 1.5e-06 4.2e-07
11 Adipose isoform ratio XM_063285943.1 0.08 0.05 6.2e-08 0.06 0.05 0.05 0.05 3.6e-07 2.4e-06 7.1e-06 1.4e-06
12 Liver gene expression Serpinh1 0.8 0.09 0.0e+00 0.56 0.6 0.6 0.59 6.6e-75 2.0e-82 1.6e-83 1.7e-81
13 Adipose intron excision ratio chr1_163059338_163061672 0.03 0.03 1.5e-03 0.02 0.02 0.02 0.02 1.6e-03 5.2e-03 2.7e-03 4.0e-03
14 Adipose intron excision ratio chr1_163059338_163062875 0.03 0.02 2.4e-03 0.02 0.02 0.02 0.02 9.4e-04 4.7e-03 2.0e-03 1.4e-03
15 Adipose gene expression Serpinh1 0.54 0.17 1.5e-11 0.08 0.12 0.13 0.08 3.4e-09 4.9e-13 1.8e-14 4.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.33.20.2-0.70.70.0-0.10.10.10.0-0.0-0.00.00.4-0.60.61.8
Area under the delay curve0.10.10.4-0.10.3-0.30.1-0.10.10.1-0.10.10.1-0.1-0.30.6-0.6-0.4
BMI with tail0.00.20.4-0.10.6-0.60.6-0.30.30.3-0.50.50.3-0.3-0.00.3-0.3-0.1
BMI without tail0.62.03.90.91.4-1.41.5-1.41.41.4-1.51.51.3-1.31.21.3-1.32.0
Body weight0.21.01.60.51.3-1.31.2-0.90.90.9-1.01.00.9-0.90.51.2-1.20.9
Weight adjusted by age0.50.71.90.50.7-0.70.7-0.70.70.7-0.80.80.6-0.60.41.4-1.41.0
Bone surface2.03.710.42.01.3-1.32.0-1.91.91.9-2.02.01.8-1.82.11.3-1.33.2
Bone volume1.12.08.11.40.8-0.81.3-1.41.41.4-1.31.31.3-1.31.60.8-0.82.8
Breakpoint value in progressive ratio session1.21.52.2-1.2-1.11.1-1.31.2-1.2-1.21.2-1.2-1.21.2-1.4-1.01.0-1.5
Number of licking bursts3.55.77.3-2.6-2.42.4-2.22.3-2.3-2.32.3-2.3-2.32.3-2.3-2.72.7-2.1
Context. condit. distance diff. score2.63.24.22.01.4-1.42.0-1.91.91.9-1.91.91.8-1.81.71.6-1.61.8
Locomotion velocity, session 10.90.92.1-0.8-0.60.6-1.40.9-0.9-0.91.1-1.1-1.01.0-0.8-0.90.9-1.1
Locomotion distance, session 10.20.20.80.50.9-0.90.1-0.20.20.2-0.10.10.1-0.10.30.7-0.7-0.6
Locomotion velocity, session 20.00.10.2-0.10.5-0.5-0.4-0.10.10.1-0.10.10.1-0.10.10.1-0.1-0.3
Locomotion distance, session 20.20.30.80.60.9-0.90.0-0.50.50.5-0.40.40.5-0.50.60.6-0.60.2
Locomotion velocity, session 30.10.20.40.60.6-0.60.4-0.30.30.3-0.30.30.3-0.30.40.5-0.5-0.2
Locomotion distance, session 30.20.20.60.80.7-0.70.4-0.50.50.5-0.40.40.5-0.50.70.2-0.2-0.2
Stereotopy head waving bouts, day 30.20.20.4-0.6-0.40.4-0.40.4-0.4-0.40.5-0.5-0.40.4-0.4-0.40.4-0.4
Stereotopy head waving duration, day 30.30.30.50.60.3-0.30.6-0.50.50.5-0.50.50.6-0.60.60.7-0.70.7
Locomotion velocity, session 70.40.40.8-0.5-0.60.6-0.50.7-0.7-0.70.6-0.6-0.70.7-0.7-0.60.6-0.9
Locomotion distance, session 70.10.10.3-0.3-0.40.4-0.20.3-0.3-0.30.2-0.2-0.30.3-0.4-0.50.5-0.6
Stereotopy head waving bouts, day 71.71.92.21.51.5-1.51.3-1.41.41.4-1.31.31.4-1.41.41.4-1.41.0
Stereotopy head waving duration, day 72.83.43.91.91.9-1.91.8-1.81.81.8-1.71.71.8-1.81.82.0-2.01.8
Locomotion velocity, session 81.61.92.61.61.0-1.01.3-1.61.61.6-1.41.41.5-1.51.51.0-1.01.6
Locomotion distance, session 81.82.63.31.81.8-1.81.5-1.61.61.6-1.61.61.6-1.61.61.7-1.71.1
Degree of sensitization distance0.00.00.1-0.4-0.20.20.20.0-0.0-0.0-0.20.2-0.10.1-0.30.1-0.10.3
Degree of sensitization stereotypy3.74.05.32.12.3-2.31.8-2.02.02.0-1.91.92.0-2.02.02.1-2.11.4
Conditioned locomotion0.20.20.3-0.2-0.40.4-0.40.5-0.5-0.50.5-0.5-0.40.4-0.3-0.60.6-0.3
Cocaine response after cond. corrected2.32.85.4-1.8-1.31.3-1.31.8-1.8-1.81.5-1.5-1.81.8-1.9-1.51.5-2.3
Cocaine response after cond. not corrected1.31.54.6-1.2-0.70.7-0.91.3-1.3-1.31.1-1.1-1.31.3-1.4-1.11.1-2.1
Cocaine response before conditioning1.01.22.21.41.1-1.10.8-1.21.21.2-0.90.91.2-1.21.50.7-0.70.9
Saline control response1.72.24.41.41.7-1.71.4-1.31.31.3-1.31.31.3-1.31.32.1-2.11.3
Bone: connectivity density0.40.64.20.9-0.20.20.7-0.70.70.7-0.70.70.6-0.61.0-0.10.12.1
Bone: cortical apparent density1.11.62.4-1.4-1.31.3-1.31.2-1.2-1.21.3-1.3-1.11.1-1.0-1.61.6-0.8
Bone: cortical area0.50.81.50.90.6-0.61.2-0.90.90.9-1.11.10.8-0.80.90.4-0.41.2
Bone: cortical porosity0.10.10.30.50.6-0.60.3-0.30.30.3-0.20.20.3-0.30.20.5-0.5-0.4
Bone: cortical porosity0.10.20.40.50.6-0.60.2-0.40.40.4-0.20.20.4-0.40.40.5-0.5-0.2
Bone: cortical thickness0.30.50.9-0.6-0.90.9-0.50.8-0.8-0.80.5-0.5-0.80.8-0.6-0.90.9-0.1
Bone: cortical thickness0.10.10.40.20.3-0.30.20.1-0.1-0.10.1-0.1-0.10.10.2-0.30.3-0.7
Bone: cortical tissue density1.21.72.5-1.4-1.31.3-1.41.2-1.2-1.21.3-1.3-1.21.2-1.1-1.61.6-0.9
Condit. Reinf. active minus inactive responses0.60.72.10.70.7-0.70.7-0.70.70.7-0.80.80.7-0.70.80.9-0.91.4
Condit. Reinf. active-inactive response ratio1.61.74.11.21.0-1.01.4-1.31.31.3-1.41.41.3-1.31.31.1-1.12.0
Condit. Reinf. active responses0.10.10.60.10.3-0.30.0-0.20.20.2-0.20.20.2-0.20.30.6-0.60.8
Condit. Reinf. inactive responses0.20.20.6-0.5-0.10.1-0.80.5-0.5-0.50.6-0.6-0.50.5-0.4-0.00.0-0.6
Incentive salience index mean0.60.82.00.70.8-0.80.6-0.80.80.8-0.70.70.8-0.80.81.2-1.21.4
Condit. Reinf. lever presses0.40.61.10.60.8-0.80.4-0.70.70.7-0.50.50.8-0.80.81.0-1.00.9
Condit. Reinf. active minus inactive responses7.59.714.73.03.6-3.63.1-3.03.03.0-2.92.92.9-2.92.73.8-3.82.0
Condit. Reinf. active-inactive response ratio1.01.23.01.01.5-1.51.0-0.80.80.8-0.70.70.8-0.80.71.7-1.70.1
Condit. Reinf. active responses11.115.420.03.84.4-4.43.9-3.83.83.8-3.83.83.8-3.83.64.5-4.52.9
Condit. Reinf. inactive responses7.19.29.82.93.1-3.12.9-3.13.13.1-3.03.03.1-3.13.03.1-3.12.8
Condit. Reinf. lever presses20.227.931.05.55.5-5.55.6-5.25.25.2-5.35.35.3-5.35.05.6-5.63.9
Condit. Reinf. lever reinforcers received12.217.021.94.04.6-4.64.1-4.14.14.1-4.04.04.0-4.03.84.7-4.72.9
Conditioned reinforcement - actives0.71.21.51.21.0-1.01.1-1.11.11.1-1.11.11.1-1.11.11.1-1.11.2
Conditioned reinforcement - inactives0.60.91.4-1.0-1.01.0-0.90.9-0.9-0.90.9-0.9-0.90.9-1.1-0.40.4-1.2
Conditioned locomotion0.30.30.90.90.6-0.60.5-0.50.50.5-0.50.50.5-0.50.60.8-0.80.0
Patch foraging indifference point 0 sec5.29.611.63.33.0-3.03.4-3.23.23.2-3.23.23.1-3.13.02.9-2.92.4
Patch foraging indifference point AUC0.40.51.00.50.8-0.80.7-0.60.60.6-0.80.80.7-0.70.60.8-0.81.0
Delay disc. indifference point, 0s delay1.01.12.10.91.4-1.40.9-0.90.90.9-0.90.90.9-0.90.91.4-1.40.2
Delay disc. indifference point, 16s delay0.10.10.4-0.4-0.30.3-0.30.3-0.3-0.30.3-0.3-0.30.3-0.5-0.20.2-0.6
Delay disc. indifference point, 2s delay1.01.12.30.61.4-1.41.0-1.01.01.0-1.01.01.0-1.00.41.5-1.5-0.7
Delay disc. indifference point, 24s delay0.80.91.4-1.0-1.21.2-0.90.9-0.9-0.90.9-0.9-0.90.9-0.9-0.80.80.5
Delay disc. indifference point, 4s delay0.90.93.60.41.6-1.60.5-0.50.50.5-0.50.50.5-0.50.31.9-1.9-0.2
Delay disc. indifference point, 8s delay0.30.40.60.50.5-0.50.6-0.60.60.6-0.60.60.6-0.60.30.8-0.80.4
Indifference point function ln k0.30.61.41.20.6-0.60.8-0.80.80.8-0.70.70.8-0.80.90.7-0.70.2
Indifference point function log k0.30.61.41.20.6-0.60.8-0.80.80.8-0.70.70.8-0.80.90.7-0.70.2
Patch foraging total patch changes 0 sec4.38.09.83.02.8-2.83.1-2.92.92.9-2.92.92.8-2.82.72.7-2.72.1
Patch foraging total patch changes 12 sec3.14.04.81.82.1-2.12.0-2.02.02.0-2.22.21.9-1.91.91.8-1.82.1
Patch foraging total patch changes 18 sec3.75.76.72.32.4-2.42.3-2.52.52.5-2.62.62.4-2.42.51.9-1.92.4
Patch foraging total patch changes 24 sec0.50.92.00.71.4-1.40.7-1.01.01.0-1.01.00.9-0.90.61.0-1.00.3
Patch foraging total patch changes 6 sec1.72.63.31.71.4-1.41.8-1.51.51.5-1.71.71.5-1.51.41.7-1.71.8
Patch foraging time to switch 0 sec3.77.58.6-2.9-2.82.8-2.92.7-2.7-2.72.6-2.6-2.82.8-2.8-2.82.8-2.1
Patch foraging water rate 0 sec2.65.46.52.52.5-2.52.5-2.32.32.3-2.42.42.4-2.42.42.1-2.11.2
Patch foraging water rate 12 sec1.22.53.21.81.5-1.51.5-1.61.61.6-1.51.51.6-1.61.71.6-1.61.3
Patch foraging water rate 18 sec0.60.91.31.11.1-1.11.0-0.90.90.9-0.90.90.9-0.91.11.0-1.00.6
Patch foraging water rate 24 sec0.40.51.11.10.7-0.70.6-0.70.70.7-0.80.80.7-0.70.90.7-0.70.3
Patch foraging water rate 6 sec0.40.51.01.00.6-0.60.8-0.80.80.8-0.70.70.8-0.80.90.4-0.40.1
Seeking ratio, delayed vs. immediate footshock2.43.03.7-1.6-1.61.6-1.91.9-1.9-1.91.8-1.8-1.71.7-1.4-1.91.9-1.0
Distance traveled before self-admin0.20.30.6-0.7-0.80.8-0.50.5-0.5-0.50.6-0.6-0.50.5-0.8-0.10.10.4
Distance traveled after self-admin2.02.53.3-1.4-1.61.6-1.81.8-1.8-1.81.8-1.8-1.81.8-1.6-1.01.0-1.0
Extensor digitorum longus weight0.10.42.60.20.2-0.20.7-0.50.50.5-0.70.70.5-0.50.40.6-0.61.6
Bone: elastic displacement2.22.53.2-1.4-1.81.8-1.31.6-1.6-1.61.4-1.4-1.61.6-1.6-1.81.8-1.3
Bone: elastic work2.12.73.7-1.5-1.91.9-1.51.7-1.7-1.71.5-1.5-1.71.7-1.6-1.91.9-1.0
Bone: endosteal estimation2.14.75.22.02.1-2.12.2-2.32.32.3-2.22.22.2-2.22.11.9-1.92.3
Bone: endosteal perimeter3.16.67.52.42.5-2.52.6-2.72.72.7-2.52.52.6-2.62.52.4-2.42.6
Epididymis fat weight0.30.91.8-1.2-0.60.6-0.91.0-1.0-1.01.0-1.0-0.90.9-1.4-0.50.5-1.0
Delta time in closed arm before/after self-admin0.20.20.7-0.8-0.70.7-0.30.3-0.3-0.30.4-0.4-0.30.3-0.70.0-0.00.4
Delta time in open arm before/after self-admin2.92.83.91.91.8-1.81.8-1.81.81.8-1.81.81.8-1.82.01.0-1.00.9
Diff in mean of infusions in LGA sessions6.47.89.6-3.1-2.62.6-3.02.9-2.9-2.92.9-2.9-2.92.9-3.1-2.42.4-2.0
Delay discount exponential model param0.10.10.40.2-0.30.3-0.00.0-0.0-0.00.0-0.0-0.00.00.3-0.60.60.4
Extinction: sum of active levers before priming0.00.00.1-0.10.0-0.0-0.0-0.10.10.1-0.10.10.1-0.1-0.20.3-0.3-0.1
Active lever presses in extinction session 60.30.30.70.80.5-0.50.4-0.40.40.4-0.40.40.4-0.40.40.6-0.6-0.8
Bone: final force0.10.10.50.1-0.30.30.30.1-0.1-0.1-0.10.1-0.10.1-0.0-0.70.70.3
Bone: final moment0.10.10.50.4-0.10.10.5-0.10.10.1-0.40.40.2-0.20.3-0.40.40.7
Food consumed during 24 hour testing period2.73.86.02.12.1-2.11.4-1.81.81.8-1.61.61.9-1.92.32.0-2.02.5
Glucose0.00.10.2-0.2-0.20.2-0.20.2-0.2-0.20.4-0.4-0.20.2-0.3-0.20.2-0.3
Heart weight0.71.11.51.21.0-1.01.2-1.01.01.0-1.11.11.0-1.01.01.0-1.01.2
Delay discount hyperbolic model param0.10.10.60.0-0.50.5-0.20.2-0.2-0.20.2-0.2-0.20.20.1-0.80.80.3
Intermittent access intake day 1-15 change0.40.91.41.20.8-0.81.0-1.11.11.1-1.11.11.1-1.11.10.5-0.50.1
Intermittent access intake escalation0.61.11.71.30.9-0.91.1-1.21.21.2-1.21.21.2-1.21.20.7-0.70.3
Intermittent access intake escalation 20.91.01.41.21.0-1.01.1-1.11.11.1-1.11.11.1-1.11.20.5-0.50.0
Intermitt. access day 1 inactive lever presses1.03.65.2-2.0-1.61.6-1.92.0-2.0-2.02.0-2.0-2.02.0-2.0-1.61.6-2.3
Intermitt. access day 15 inactive lever presses1.32.63.2-1.6-1.51.5-1.71.8-1.8-1.81.8-1.8-1.81.8-1.6-1.21.2-1.2
Intermitt. access escalation Index0.00.00.40.1-0.20.20.1-0.00.00.0-0.00.00.0-0.00.00.2-0.20.6
Intermittent access day 1 total infusions0.60.92.31.00.8-0.80.9-0.80.80.8-0.80.80.8-0.80.91.2-1.21.5
Intermittent access day 15 total infusions0.91.42.11.41.0-1.01.2-1.21.21.2-1.21.21.2-1.21.31.0-1.01.0
Intermittent access terminal intake (last 3 days)1.72.23.11.71.3-1.31.6-1.61.61.6-1.61.61.6-1.61.71.2-1.21.3
Intermittent access total infusions1.41.62.11.41.1-1.11.4-1.31.31.3-1.31.31.3-1.31.50.9-0.91.2
Intermittent access day 1 locomotion0.10.10.50.50.0-0.00.3-0.20.20.2-0.20.20.2-0.20.40.1-0.10.7
Intermittent access day 15 total locomotion0.40.81.41.20.7-0.70.9-1.01.01.0-1.01.01.0-1.01.10.6-0.60.6
Intermittent access total locomotion0.50.71.01.00.6-0.60.9-0.90.90.9-0.90.90.9-0.90.90.5-0.50.9
Intermittent access standard deviation0.30.50.60.60.8-0.80.7-0.80.80.8-0.80.80.8-0.80.80.6-0.60.5
Left kidney weight0.31.42.50.71.4-1.41.0-1.11.11.1-1.01.01.1-1.10.91.6-1.61.5
Right kidney weight0.41.72.70.91.6-1.61.3-1.31.31.3-1.31.31.3-1.31.21.2-1.21.4
Cocaine induced anxiety0.91.22.3-1.0-1.41.4-1.01.0-1.0-1.01.0-1.0-1.01.0-0.9-1.51.5-0.4
Post-drug Anxiety1.21.32.2-1.2-1.51.5-1.11.1-1.1-1.11.1-1.1-1.11.1-1.1-1.21.2-0.3
Baseline Anxiety0.20.30.70.40.4-0.40.5-0.50.50.5-0.50.50.5-0.50.30.8-0.80.4
Tail length1.03.88.91.41.8-1.81.8-1.91.91.9-1.81.81.8-1.81.82.2-2.23.0
Length with tail0.41.92.81.01.5-1.51.4-1.31.31.3-1.31.31.3-1.31.11.7-1.71.6
Length without tail0.30.83.2-0.9-0.30.3-0.80.9-0.9-0.91.0-1.0-0.80.8-0.9-0.60.6-1.8
Times rat made contact with spout0.10.10.3-0.2-0.10.1-0.1-0.00.00.00.2-0.20.0-0.00.2-0.60.60.3
Lifetime Intake1.41.72.11.51.2-1.21.4-1.41.41.4-1.41.41.4-1.41.40.9-0.91.0
Liver weight, left0.00.10.5-0.30.2-0.2-0.00.0-0.0-0.00.0-0.0-0.00.0-0.1-0.30.3-0.7
Liver weight, right0.50.91.6-1.3-0.50.5-1.01.0-1.0-1.00.9-0.9-1.01.0-0.8-1.21.2-0.7
Locomotor activity1.21.83.51.61.2-1.21.4-1.31.31.3-1.01.01.3-1.31.71.1-1.11.9
Locomotor testing distance2.34.25.52.12.2-2.22.0-2.12.12.1-1.81.82.1-2.12.31.9-1.92.2
Locomotor testing rearing0.91.72.61.21.6-1.61.2-1.51.51.5-1.31.31.5-1.51.60.6-0.60.7
Locomotion in novel chamber0.40.51.21.00.5-0.50.6-0.50.50.5-0.60.60.6-0.60.91.0-1.01.1
Locomotion in novel chamber post-restriction1.11.92.61.61.4-1.41.5-1.51.51.5-1.51.51.5-1.51.30.9-0.9-0.6
Fecal boli incidents, locomotor time 10.20.30.70.80.7-0.70.4-0.30.30.3-0.30.30.3-0.30.80.5-0.50.6
Change in fecal boli incidents, locomotor task0.80.81.6-1.1-1.01.0-0.90.9-0.9-0.90.8-0.8-0.90.9-1.3-0.70.7-0.8
Time >=10cm from walls, locomotor time 11.01.12.11.21.1-1.11.1-1.01.01.0-1.01.01.0-1.00.81.4-1.40.3
Bouts of movement, locomotor time 10.30.31.90.10.3-0.3-0.00.1-0.1-0.10.0-0.0-0.10.1-0.21.4-1.40.4
Total resting periods, locomotor time 10.20.20.8-0.1-0.10.1-0.40.4-0.4-0.40.3-0.3-0.40.4-0.40.9-0.90.4
Rest time, locomotor task time 10.81.01.3-0.8-0.60.6-1.01.1-1.1-1.11.1-1.1-1.11.1-1.10.8-0.80.7
Distance moved, locomotor task time 10.81.21.80.90.6-0.61.3-1.31.31.3-1.31.31.3-1.31.3-0.80.80.1
Vertical activity count, locomotor time 10.81.92.91.30.9-0.91.7-1.71.71.7-1.71.71.7-1.71.6-0.20.20.3
Time >=10cm from walls, locomotor time 20.81.12.90.91.4-1.40.9-0.80.80.8-0.80.80.8-0.80.81.7-1.70.6
Bouts of movement, locomotor time 20.50.71.50.61.0-1.00.7-0.80.80.8-0.90.90.8-0.80.51.2-1.20.1
Total resting periods, locomotor time 20.20.30.80.20.7-0.70.4-0.50.50.5-0.50.50.5-0.50.10.9-0.9-0.4
Rest time, locomotor task time 22.12.63.5-1.7-1.91.9-1.61.7-1.7-1.71.7-1.7-1.71.7-1.7-1.51.5-0.3
Distance moved, locomotor task time 22.53.04.41.82.1-2.11.8-1.81.81.8-1.91.91.8-1.81.81.3-1.30.3
Vertical activity count, locomotor time 22.02.73.71.61.6-1.61.7-1.81.81.8-1.91.91.8-1.81.71.1-1.10.9
Light reinforcement 10.82.12.8-1.7-1.41.4-1.41.5-1.5-1.51.5-1.5-1.51.5-1.5-1.31.3-0.7
Light reinforcement 20.20.20.4-0.3-0.40.4-0.40.6-0.6-0.60.5-0.5-0.60.6-0.40.3-0.30.3
Bone: marrow area1.94.14.71.81.9-1.92.1-2.12.12.1-2.12.12.1-2.12.01.8-1.82.2
Bone: maximum diameter2.95.46.62.32.1-2.12.6-2.42.42.4-2.52.52.3-2.32.22.1-2.12.5
Bone: maximum force0.10.20.60.5-0.10.10.7-0.40.40.4-0.60.60.3-0.30.4-0.30.30.8
Bone: maximum moment0.20.41.50.70.2-0.20.9-0.60.60.6-0.80.80.6-0.60.6-0.00.01.2
Mean time between licks in bursts2.76.79.42.33.1-3.12.4-2.52.52.5-2.52.52.5-2.52.52.8-2.82.0
Mean num. licks in bursts3.55.46.62.62.3-2.32.2-2.32.32.3-2.22.22.3-2.32.42.4-2.42.2
Cd content in liver0.10.10.3-0.5-0.30.3-0.20.3-0.3-0.30.2-0.2-0.30.3-0.4-0.20.2-0.4
Co content in liver1.51.72.21.21.5-1.51.1-1.41.41.4-1.31.31.4-1.41.41.0-1.00.6
Cu content in liver0.40.51.50.21.2-1.20.2-0.50.50.5-0.30.30.5-0.50.51.2-1.20.1
Fe content in liver0.10.20.5-0.3-0.30.3-0.10.4-0.4-0.40.4-0.4-0.40.4-0.5-0.30.3-0.7
K content in liver0.00.00.1-0.30.1-0.1-0.4-0.00.00.00.1-0.10.0-0.0-0.00.2-0.20.0
Mg content in liver0.10.10.40.10.5-0.50.0-0.20.20.2-0.10.10.2-0.20.20.1-0.1-0.6
Mn content in liver2.02.33.0-1.3-1.31.3-1.51.5-1.5-1.51.5-1.5-1.51.5-1.4-1.71.7-1.6
Na content in liver0.30.30.80.50.8-0.80.5-0.60.60.6-0.30.30.6-0.60.50.3-0.3-0.9
Rb content in liver0.81.01.71.10.8-0.80.9-1.11.11.1-0.90.91.1-1.11.30.5-0.51.2
Se content in liver7.89.311.1-3.2-2.82.8-3.33.3-3.3-3.33.2-3.2-3.33.3-3.2-2.42.4-2.2
Sr content in liver0.10.10.30.30.1-0.10.2-0.10.10.1-0.30.30.1-0.10.3-0.50.5-0.4
Zn content in liver3.43.85.31.82.3-2.31.7-1.91.91.9-1.81.81.9-1.91.92.2-2.21.5
Bone: minimum diameter0.91.72.91.01.2-1.21.4-1.41.41.4-1.41.41.3-1.31.31.1-1.11.7
Time in familiar zone, hab. session 10.00.00.1-0.1-0.10.1-0.2-0.20.20.2-0.00.00.1-0.10.1-0.30.30.0
Time in novel zone, hab. session 10.10.10.2-0.3-0.30.3-0.00.4-0.4-0.40.2-0.2-0.30.3-0.4-0.10.1-0.1
Total zone transitions, hab. session 10.00.00.10.3-0.10.10.0-0.10.10.1-0.10.10.0-0.00.20.0-0.00.4
Total locomotion distance, hab. session 10.30.40.7-0.8-0.30.3-0.60.6-0.6-0.60.6-0.6-0.60.6-0.5-0.70.7-0.8
Locomotion velocity, hab. session 10.10.20.3-0.6-0.20.2-0.40.4-0.4-0.40.4-0.4-0.40.4-0.3-0.50.5-0.6
Time in familiar zone, hab. session 22.83.05.71.71.3-1.31.7-1.81.81.8-1.81.81.9-1.91.91.3-1.32.4
Time in novel zone, hab. session 21.61.64.6-1.2-0.60.6-1.21.4-1.4-1.41.3-1.3-1.41.4-1.3-0.90.9-2.1
Total zone transitions, hab. session 20.70.91.81.11.2-1.20.7-0.80.80.8-0.90.90.7-0.70.81.3-1.30.5
Total locomotion distance, hab. session 20.10.10.6-0.10.6-0.60.0-0.10.10.1-0.10.10.1-0.10.10.8-0.80.3
Locomotion velocity, hab. session 20.10.10.3-0.30.6-0.6-0.10.1-0.1-0.10.0-0.0-0.10.1-0.10.6-0.6-0.1
Novel to familiar place preference ratio0.10.10.6-0.10.1-0.10.10.1-0.1-0.10.0-0.0-0.20.2-0.30.3-0.3-0.8
Novelty place preference0.10.10.8-0.20.1-0.10.00.2-0.2-0.20.2-0.2-0.30.3-0.40.2-0.2-0.9
Time in novel zone, NPP test0.10.10.30.00.3-0.30.20.0-0.0-0.0-0.10.1-0.10.1-0.20.4-0.4-0.6
Total zone transitions, NPP test0.00.10.20.10.2-0.2-0.40.2-0.2-0.20.2-0.2-0.20.2-0.10.3-0.3-0.4
Total locomotion distance, NPP test0.81.11.6-1.3-0.20.2-1.21.3-1.3-1.31.1-1.1-1.31.3-1.2-0.10.1-1.2
Locomotion velocity, NPP test1.42.02.7-1.7-0.50.5-1.61.6-1.6-1.61.5-1.5-1.71.7-1.6-0.50.5-1.7
Intraocular pressure0.10.10.40.50.2-0.20.3-0.40.40.4-0.40.40.4-0.40.4-0.10.1-0.6
Delta distance traveled before/after self-admin0.00.00.20.40.3-0.3-0.1-0.00.00.00.0-0.00.0-0.00.30.4-0.4-0.2
Delta ambulatory time before/after self-admin0.00.10.20.30.2-0.2-0.20.0-0.0-0.00.1-0.1-0.00.00.20.5-0.5-0.5
Parametrial fat weight0.30.61.4-1.0-0.90.9-0.60.8-0.8-0.80.7-0.7-0.80.8-1.2-0.40.4-0.4
Pavlov. Cond. lever latency2.22.84.1-1.7-1.71.7-1.41.7-1.7-1.71.5-1.5-1.81.8-2.0-1.41.4-1.9
Pavlov. Cond. magazine entry latency4.35.56.92.52.4-2.42.5-2.42.42.4-2.32.32.5-2.52.62.0-2.02.0
Pavlov. Cond. change in total contacts1.21.32.11.11.5-1.51.0-1.01.01.0-0.90.91.1-1.11.21.3-1.31.0
Pavlov. Cond. index score4.15.27.02.32.3-2.32.1-2.42.42.4-2.12.12.4-2.42.62.0-2.02.3
Pavlov. Cond. latency score3.95.06.82.32.3-2.32.1-2.32.32.3-2.02.02.4-2.42.61.9-1.92.1
Pavlov. Cond. lever contacts2.22.64.11.61.6-1.61.3-1.61.61.6-1.41.41.7-1.71.91.5-1.52.0
Pavlov. Cond. magazine entry number4.55.66.9-2.5-2.52.5-2.42.4-2.4-2.42.2-2.2-2.52.5-2.6-2.22.2-2.2
Pavlov. Cond. intertrial magazine entries2.42.84.0-1.8-1.41.4-2.01.9-1.9-1.91.7-1.7-1.91.9-1.8-1.21.2-1.0
Pavlov. Cond. lever-magazine prob. diff.3.44.25.72.12.0-2.01.9-2.12.12.1-1.91.92.2-2.22.41.7-1.72.2
Pavlov. Cond. response bias2.32.94.71.61.7-1.71.4-1.71.71.7-1.41.41.7-1.71.91.6-1.62.2
Pavlov. Cond. lever latency21.429.134.2-5.6-5.75.7-5.65.3-5.3-5.35.5-5.5-5.35.3-5.1-5.85.8-3.7
Pavlov. Cond. magazine entry latency4.95.97.72.82.4-2.42.8-2.52.52.5-2.82.82.5-2.52.51.9-1.91.2
Pavlov. Cond. change in total contacts11.418.423.64.54.9-4.94.5-4.14.14.1-4.34.34.1-4.14.04.8-4.82.4
Pavlov. Cond. index score15.520.924.04.94.8-4.84.9-4.54.54.5-4.84.84.5-4.54.44.7-4.72.7
Pavlov. Cond. latency score13.618.120.84.54.5-4.54.6-4.24.24.2-4.54.54.2-4.24.14.3-4.32.4
Pavlov. Cond. lever contacts20.328.033.65.55.5-5.55.5-5.25.25.2-5.45.45.2-5.24.95.8-5.83.6
Pavlov. Cond. magazine entry number7.28.810.8-3.3-3.23.2-3.22.9-2.9-2.93.2-3.2-2.92.9-2.9-3.03.0-1.5
Pavlov. Cond. intertrial magazine entries0.10.20.60.10.4-0.40.3-0.40.40.4-0.20.20.4-0.40.40.6-0.60.8
Pavlov. Cond. lever-magazine prob. diff.14.519.422.34.64.7-4.74.7-4.44.44.4-4.64.64.3-4.34.24.5-4.52.5
Pavlov. Cond. response bias21.228.832.25.75.6-5.65.6-5.35.35.3-5.55.55.3-5.35.15.7-5.73.7
Time in closed arm before self-admin0.40.51.21.10.8-0.80.6-0.50.50.5-0.50.50.5-0.51.00.7-0.71.0
Time in closed arm after self-admin1.11.21.7-1.0-1.31.3-1.21.2-1.2-1.21.2-1.2-1.21.2-1.0-0.60.60.4
Time in open arm before self-admin2.12.34.1-1.9-1.61.6-1.71.5-1.5-1.51.6-1.6-1.51.5-2.0-0.80.8-1.3
Time in open arm after self-admin0.91.01.40.80.9-0.91.1-1.21.21.2-1.11.11.2-1.20.90.5-0.5-0.1
Bone: periosteal estimation1.73.64.51.81.8-1.82.1-2.02.02.0-2.12.11.9-1.91.91.4-1.42.0
Bone: periosteal perimeter2.64.66.42.01.8-1.82.2-2.32.32.3-2.12.12.2-2.22.22.0-2.02.5
Bone: post-yield work0.60.93.40.90.3-0.31.1-1.01.01.0-1.01.01.0-1.01.00.4-0.41.8
Progressive ratio test 1 active lever presses0.20.30.5-0.5-0.70.7-0.50.5-0.5-0.50.5-0.5-0.50.5-0.5-0.60.6-0.1
Progressive ratio test 1 breakpoint0.20.30.6-0.5-0.70.7-0.50.5-0.5-0.50.5-0.5-0.50.5-0.5-0.60.6-0.0
Progressive ratio test 1 inactive lever presses0.30.50.8-0.6-0.90.9-0.60.6-0.6-0.60.6-0.6-0.60.6-0.7-0.80.8-0.5
Progressive ratio test 2 active lever presses0.60.70.80.70.6-0.60.8-0.90.90.9-0.90.90.9-0.90.70.7-0.70.9
Progressive ratio test 2 breakpoint0.60.70.80.80.6-0.60.8-0.90.90.9-0.90.90.9-0.90.70.7-0.70.9
Progressive ratio test 2 inactive lever presses0.20.30.70.50.2-0.20.6-0.50.50.5-0.50.50.5-0.50.40.6-0.60.8
Incentive Sensitization - Responses1.72.32.61.41.4-1.41.5-1.61.61.6-1.61.61.6-1.61.31.6-1.61.5
Incentive Sensitization - Breakpoint1.62.12.31.41.3-1.31.5-1.51.51.5-1.51.51.5-1.51.31.5-1.51.4
Sum of active levers in priming session hrs 5-60.00.00.1-0.00.3-0.3-0.10.2-0.2-0.20.1-0.1-0.20.2-0.10.4-0.40.0
Progressive ratio0.10.20.40.60.5-0.50.4-0.30.30.3-0.40.40.3-0.30.7-0.30.3-0.3
Food seeking constrained by brief footshock2.02.53.11.51.8-1.81.7-1.61.61.6-1.61.61.6-1.61.61.5-1.50.9
Seeking ratio, punishment vs. effort0.71.01.40.71.0-1.01.0-1.11.11.1-1.01.01.1-1.10.81.2-1.20.8
Retroperitoneal fat weight0.41.94.6-2.1-1.41.4-1.01.3-1.3-1.31.3-1.3-1.31.3-1.8-1.31.3-0.9
Reaction time number correct0.00.10.20.1-0.10.1-0.30.2-0.2-0.20.4-0.4-0.20.2-0.00.3-0.30.0
Reaction time mean minus median0.61.62.31.41.1-1.11.5-1.41.41.4-1.31.31.4-1.41.40.9-0.90.6
Reaction time mean minus median AUC0.61.62.21.51.1-1.11.4-1.41.41.4-1.31.31.4-1.41.40.9-0.90.9
Reaction time num false alarms1.21.72.5-1.6-1.21.2-1.51.3-1.3-1.31.2-1.2-1.31.3-1.4-1.41.4-0.8
Reaction time num false alarms AUC0.71.11.8-1.3-0.90.9-1.31.1-1.1-1.11.0-1.0-1.11.1-1.2-1.11.1-0.7
Reaction time trials correct on left0.00.10.20.1-0.10.1-0.30.2-0.2-0.20.4-0.4-0.20.2-0.00.3-0.30.0
Reaction time trials on left0.00.10.20.1-0.10.1-0.30.2-0.2-0.20.4-0.4-0.20.2-0.00.3-0.3-0.0
Reaction time mean0.50.71.6-0.8-1.01.0-0.30.7-0.7-0.70.5-0.5-0.70.7-0.8-1.31.3-1.2
Reaction time mean AUC1.01.62.6-1.2-1.41.4-0.81.2-1.2-1.21.0-1.0-1.11.1-1.2-1.61.6-1.5
Median of all reaction times1.41.93.2-1.4-1.51.5-0.81.3-1.3-1.31.1-1.1-1.31.3-1.4-1.81.8-1.6
Reaction time omissions0.10.10.9-0.10.1-0.10.2-0.00.00.00.0-0.00.0-0.0-0.3-0.00.0-1.0
Reaction time false alarm rate1.01.32.1-1.4-1.01.0-1.21.1-1.1-1.10.9-0.9-1.11.1-1.3-1.51.5-1.0
Reaction time premature initiation rate2.83.85.61.91.7-1.72.4-2.12.12.1-2.32.32.1-2.12.01.3-1.31.4
Reaction time premature initiations1.73.14.21.91.5-1.52.1-1.91.91.9-2.02.01.8-1.81.91.3-1.31.3
Std. dev. reaction times0.30.61.10.70.5-0.51.0-0.90.90.9-0.90.91.0-1.00.80.2-0.2-0.1
Reaction time trials completed0.00.10.20.1-0.10.1-0.30.2-0.2-0.20.4-0.4-0.20.2-0.00.3-0.3-0.0
Reaction time trials AUC0.00.10.20.10.0-0.0-0.20.2-0.2-0.20.3-0.3-0.20.2-0.00.4-0.40.0
Run reversals in cocaine runway, females0.20.20.3-0.10.1-0.10.5-0.50.50.5-0.50.50.5-0.50.3-0.10.10.5
Run reversals in cocaine runway, males0.10.10.3-0.2-0.40.4-0.10.2-0.2-0.20.2-0.2-0.20.2-0.0-0.60.60.0
Latency to leave start box in cocaine runway3.33.78.8-2.3-1.61.6-1.71.8-1.8-1.81.7-1.7-1.81.8-2.3-1.91.9-3.0
Latency to leave start box in cocaine runway, F2.52.97.7-2.1-1.31.3-1.51.6-1.6-1.61.5-1.5-1.61.6-2.0-1.51.5-2.8
Latency to leave start box in cocaine runway, M0.70.71.2-0.8-0.80.8-0.70.7-0.7-0.70.7-0.7-0.80.8-0.9-0.90.9-1.1
Std. dev. time between licks in bursts1.62.13.11.11.8-1.81.3-1.61.61.6-1.41.41.6-1.61.41.3-1.30.8
Total sessions with >9 infusions1.82.22.81.61.5-1.51.6-1.61.61.6-1.61.61.6-1.61.70.6-0.60.4
Short access day 1 total inactive lever presses0.00.10.3-0.2-0.20.2-0.20.2-0.2-0.20.2-0.2-0.20.2-0.2-0.30.3-0.5
Short access day 10 total inactive lever presses0.61.62.0-1.3-1.31.3-1.31.4-1.4-1.41.4-1.4-1.41.4-1.3-0.80.8-0.7
Short access day 1 total infusions2.93.84.32.02.1-2.12.1-2.12.12.1-2.12.12.1-2.12.01.5-1.51.2
Short access day 10 total infusions1.01.31.71.21.3-1.31.2-1.21.21.2-1.21.21.2-1.21.20.9-0.90.6
Short access total infusions1.62.02.21.51.5-1.51.5-1.51.51.5-1.51.51.5-1.51.41.2-1.20.8
Short access day 1 locomotion1.72.13.01.71.5-1.51.6-1.61.61.6-1.61.61.6-1.61.60.8-0.80.3
Short access day 10 total locomotion0.91.72.41.61.4-1.41.3-1.41.41.4-1.41.41.4-1.41.60.8-0.80.5
Short access total locomotion0.50.60.91.00.7-0.70.8-0.80.80.8-0.80.80.8-0.81.0-0.10.1-0.1
One hour access (0.3 mA shock)1.11.31.91.41.1-1.11.2-1.21.21.2-1.21.21.2-1.21.40.6-0.60.9
Compulsive drug intake0.60.80.9-0.7-0.80.8-0.91.0-1.0-1.01.0-1.0-1.01.0-0.9-0.60.6-0.9
One hour access (shock baseline)1.11.72.61.51.3-1.31.4-1.41.41.4-1.41.41.4-1.41.60.8-0.80.8
Social response proportion0.60.71.2-0.8-0.70.7-0.70.8-0.8-0.80.7-0.7-0.90.9-0.6-1.11.1-0.7
Social responses0.30.30.9-0.7-0.20.2-0.50.5-0.5-0.50.5-0.5-0.50.5-0.4-0.90.9-0.8
Social time4.96.67.7-2.5-2.12.1-2.62.7-2.7-2.72.8-2.8-2.72.7-2.5-2.42.4-2.8
Soleus weight0.10.31.00.00.2-0.20.6-0.60.60.6-0.70.70.6-0.60.30.3-0.31.0
Bone: stiffness0.20.30.6-0.5-0.80.8-0.20.5-0.5-0.50.3-0.3-0.50.5-0.6-0.80.8-0.1
Tibialis anterior weight0.20.71.20.60.7-0.70.9-0.70.70.7-0.80.80.8-0.80.61.1-1.11.1
Time to tail flick, vehicle, before self-admin0.60.71.91.00.2-0.20.7-0.80.80.8-0.90.90.8-0.81.3-0.40.41.4
Time to tail flick, vehicle, after self-admin1.21.62.11.41.2-1.21.4-1.21.21.2-1.31.31.2-1.21.31.1-1.11.3
Time to tail flick, test, before self-admin0.60.60.80.60.6-0.60.8-0.90.90.9-0.80.80.9-0.90.80.9-0.90.7
Time to tail flick, test, after self-admin0.20.20.80.20.6-0.60.3-0.40.40.4-0.40.40.4-0.40.30.9-0.90.4
Delta time to tail flick, vehicle, before/after SA0.50.51.40.50.8-0.80.8-0.60.60.6-0.60.60.6-0.60.11.2-1.2-0.3
Delta time to tail flick, test, before/after SA0.70.71.0-0.9-0.60.6-0.90.9-0.9-0.90.9-0.9-0.90.9-1.0-0.50.5-0.8
Tibia length0.92.44.02.01.8-1.81.7-1.61.61.6-1.61.61.6-1.61.71.1-1.10.1
Ambulatory time before self-admin0.71.11.6-1.1-1.21.2-1.01.1-1.1-1.11.1-1.1-1.11.1-1.3-0.70.7-0.4
Ambulatory time after self-admin1.92.33.2-1.2-1.41.4-1.81.7-1.7-1.71.8-1.8-1.71.7-1.5-0.70.7-1.0
Bone: tissue strength0.70.71.1-0.5-1.11.1-0.60.8-0.8-0.80.7-0.7-0.80.8-0.9-0.80.8-0.6
Total heroin consumption0.00.00.1-0.10.2-0.2-0.30.0-0.0-0.00.2-0.2-0.00.0-0.10.4-0.40.0
Bone: trabecular number0.61.12.7-0.7-1.61.6-0.80.8-0.8-0.80.7-0.7-0.90.9-0.6-1.41.41.1
Bone: trabecular spacing0.50.61.60.71.1-1.10.6-0.60.60.6-0.60.60.7-0.70.41.2-1.2-0.5
Bone: trabecular thickness0.10.20.8-0.2-0.60.6-0.10.2-0.2-0.20.4-0.4-0.30.3-0.1-0.20.20.9
Bone: trabecular tissue density1.11.62.7-1.6-1.11.1-1.21.3-1.3-1.31.3-1.3-1.31.3-1.6-0.80.8-1.2
Water consumed over 24 hours0.40.60.9-0.7-0.90.9-1.00.6-0.6-0.60.9-0.9-0.70.7-0.5-1.01.00.2
Number of responses in last shaping day0.00.10.2-0.3-0.10.1-0.10.1-0.1-0.10.1-0.1-0.10.1-0.0-0.40.40.4