Hub : Genes

Serpinh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Serpinh1 0.04 0.03 3.8e-04 0.01 0.02 0.02 0.02 8.0e-03 1.3e-03 1.9e-03 3.2e-03
2 Liver isoform ratio XM_039107102.1 0.04 0.03 1.4e-03 0.02 0.02 0.02 0.02 4.2e-03 1.5e-03 3.0e-03 5.0e-03
3 Liver isoform ratio NM_017173.2 0.04 0.03 9.0e-04 0.02 0.02 0.02 0.02 2.9e-03 1.1e-03 1.1e-03 2.6e-03
4 Adipose intron excision ratio chr1_153647208_153649542 0.04 0.03 6.8e-04 0.02 0.02 0.02 0.02 9.3e-04 2.1e-03 1.4e-03 1.4e-03
5 Adipose isoform ratio XM_039107102.1 0.08 0.05 1.4e-07 0.04 0.05 0.05 0.05 1.5e-05 2.5e-06 1.2e-06 3.9e-06
6 Adipose mRNA stability Serpinh1 0.13 0.07 7.6e-13 0.1 0.1 0.1 0.1 1.8e-11 2.7e-11 2.2e-11 3.6e-11
7 Adipose isoform ratio NM_017173.2 0.08 0.04 2.2e-07 0.03 0.05 0.05 0.04 3.0e-04 4.3e-06 2.3e-06 8.3e-06
8 Brain mRNA stability Serpinh1 0.08 0.06 2.0e-05 0.05 0.05 0.04 0.05 8.7e-06 2.7e-05 5.5e-05 2.5e-05
9 Liver gene expression Serpinh1 0.81 0.08 0.0e+00 0.56 0.59 0.59 0.58 1.3e-74 1.4e-80 5.0e-81 1.5e-79
10 NAcc mRNA stability Serpinh1 0.02 0.02 2.6e-03 0.01 0.02 0.01 0.02 1.5e-02 4.3e-03 1.1e-02 4.1e-03
11 Adipose intron excision ratio chr1_153647208_153650745 0.03 0.02 1.9e-03 0.01 0.02 0.01 0.01 8.1e-03 3.4e-03 7.4e-03 6.8e-03
12 Adipose gene expression Serpinh1 0.56 0.17 2.3e-11 0.08 0.12 0.13 0.08 1.3e-09 6.0e-13 5.4e-14 2.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.40.77.8-0.2-0.20.20.40.1-0.2-0.1-0.1-0.50.10.2-2.8
Area under the delay curve0.10.11.0-0.0-0.00.0-0.2-0.1-0.00.1-0.10.20.1-0.11.0
BMI with tail0.00.10.7-0.3-0.30.3-0.1-0.4-0.10.40.10.3-0.2-0.10.8
BMI without tail0.71.43.30.30.2-0.2-1.30.4-1.5-0.3-1.3-1.41.4-1.8-1.6
Body weight0.20.62.60.0-0.10.1-1.2-0.2-1.10.3-1.1-0.70.9-1.60.1
Weight adjusted by age0.70.81.70.70.6-0.6-1.00.6-1.0-0.6-1.1-1.11.2-1.3-0.7
Bone surface2.13.713.01.41.4-1.4-1.31.7-2.0-1.6-1.9-2.11.8-1.6-3.6
Bone volume1.52.512.41.01.0-1.0-1.01.2-1.5-1.2-1.4-1.81.4-1.2-3.5
Breakpoint value in progressive ratio session0.30.30.4-0.4-0.40.40.5-0.40.60.40.60.6-0.60.70.6
Number of licking bursts5.46.48.3-2.8-2.82.82.3-2.92.32.92.02.6-2.42.12.1
Context. condit. distance diff. score2.83.34.32.12.1-2.1-1.62.1-1.9-2.1-2.0-1.61.7-1.4-1.0
Locomotion velocity, session 10.60.61.4-0.4-0.30.30.7-0.41.10.41.20.8-0.91.01.0
Locomotion distance, session 10.40.51.11.01.0-1.0-0.80.7-0.1-0.8-0.1-0.20.1-0.20.9
Locomotion velocity, session 20.00.00.10.10.1-0.1-0.30.00.0-0.00.4-0.00.0-0.1-0.1
Locomotion distance, session 20.20.30.60.70.8-0.8-0.70.7-0.2-0.7-0.1-0.50.4-0.4-0.3
Locomotion velocity, session 30.40.40.90.90.9-1.0-0.50.8-0.4-0.9-0.4-0.40.3-0.2-0.1
Locomotion distance, session 30.70.81.71.21.3-1.3-0.81.2-0.5-1.2-0.5-0.60.5-0.3-0.1
Stereotopy head waving bouts, day 30.20.30.5-0.7-0.70.70.4-0.70.50.70.40.3-0.40.10.3
Stereotopy head waving duration, day 30.20.20.40.50.5-0.5-0.10.6-0.4-0.6-0.5-0.50.5-0.3-0.7
Locomotion velocity, session 70.30.40.9-0.4-0.40.40.6-0.50.60.50.40.7-0.70.71.0
Locomotion distance, session 70.10.10.2-0.3-0.30.30.4-0.40.20.40.00.4-0.30.20.5
Stereotopy head waving bouts, day 71.72.02.91.61.7-1.7-1.61.6-1.1-1.6-1.1-1.31.2-1.1-0.7
Stereotopy head waving duration, day 72.83.44.12.02.0-2.0-2.02.0-1.7-2.0-1.5-1.81.7-1.6-1.5
Locomotion velocity, session 81.51.82.31.31.3-1.3-0.81.4-1.3-1.4-1.4-1.41.4-1.1-1.5
Locomotion distance, session 81.92.74.12.02.0-2.0-1.71.9-1.5-1.9-1.5-1.51.4-1.3-0.4
Degree of sensitization distance0.40.40.9-0.8-0.90.90.3-0.9-0.11.0-0.20.2-0.1-0.40.1
Degree of sensitization stereotypy4.24.66.62.52.6-2.6-2.42.5-1.8-2.5-1.6-2.01.9-1.7-1.1
Conditioned locomotion0.00.00.1-0.0-0.00.00.4-0.00.20.00.20.2-0.20.40.1
Cocaine response after cond. corrected2.73.04.4-1.8-1.81.81.2-2.11.32.11.41.9-1.71.22.1
Cocaine response after cond. not corrected1.31.53.6-1.1-1.11.10.7-1.41.01.41.01.4-1.30.91.9
Cocaine response before conditioning1.31.52.41.41.5-1.5-1.11.5-0.7-1.5-1.0-1.31.0-0.7-1.2
Saline control response1.72.23.81.51.5-1.5-1.91.3-1.5-1.3-1.6-1.61.5-1.8-0.8
Bone: connectivity density0.81.29.90.50.4-0.50.10.8-0.8-0.8-0.6-1.00.7-0.2-3.1
Bone: cortical apparent density1.21.62.5-1.5-1.61.61.4-1.41.21.51.10.9-0.90.80.5
Bone: cortical area0.81.22.90.80.7-0.7-0.90.8-1.5-0.8-1.3-1.21.1-1.2-1.7
Bone: cortical porosity0.70.71.41.21.2-1.2-0.71.1-0.6-1.1-0.7-0.60.6-0.40.2
Bone: cortical porosity0.40.51.01.01.0-1.0-0.60.9-0.3-0.9-0.4-0.40.4-0.20.4
Bone: cortical thickness0.10.20.2-0.4-0.50.50.5-0.50.30.50.30.3-0.40.4-0.4
Bone: cortical thickness0.10.10.30.40.4-0.4-0.20.10.1-0.1-0.10.0-0.1-0.00.6
Bone: cortical tissue density1.21.62.5-1.6-1.61.61.4-1.41.21.51.21.0-1.00.90.5
Condit. Reinf. active minus inactive responses0.40.41.40.40.3-0.3-0.60.3-0.7-0.3-0.7-0.80.7-0.9-1.2
Condit. Reinf. active-inactive response ratio1.31.43.90.80.7-0.7-1.00.8-1.4-0.8-1.3-1.41.4-1.4-2.0
Condit. Reinf. active responses0.00.10.30.00.0-0.0-0.2-0.0-0.10.0-0.0-0.30.2-0.3-0.6
Condit. Reinf. inactive responses0.20.20.7-0.3-0.20.20.2-0.30.70.30.70.4-0.50.50.8
Incentive salience index mean0.40.40.80.50.5-0.5-0.70.5-0.6-0.5-0.6-0.90.7-0.9-0.9
Condit. Reinf. lever presses0.20.20.40.40.5-0.4-0.40.5-0.3-0.5-0.2-0.60.5-0.5-0.4
Condit. Reinf. active minus inactive responses6.78.312.93.03.0-3.0-3.62.7-2.9-2.7-3.1-2.82.9-3.2-0.7
Condit. Reinf. active-inactive response ratio1.21.22.51.31.3-1.3-1.61.1-0.9-1.1-1.0-0.80.8-1.10.7
Condit. Reinf. active responses9.212.818.73.63.6-3.5-4.33.3-3.7-3.2-3.9-3.83.7-4.1-1.8
Condit. Reinf. inactive responses6.17.510.22.52.4-2.4-3.12.4-2.9-2.3-2.8-3.13.0-3.2-2.5
Condit. Reinf. lever presses19.626.530.45.45.3-5.3-5.55.2-5.4-5.2-5.5-5.25.2-5.2-2.8
Condit. Reinf. lever reinforcers received10.314.521.03.93.9-3.8-4.63.6-3.9-3.5-4.0-3.93.9-4.2-1.8
Conditioned reinforcement - actives1.81.82.81.61.6-1.7-1.41.6-1.1-1.7-1.1-1.11.1-0.8-0.2
Conditioned reinforcement - inactives0.80.91.5-1.0-1.01.00.5-1.01.01.00.91.0-1.00.81.2
Conditioned locomotion0.91.02.01.31.4-1.4-0.91.4-0.6-1.4-0.6-0.80.6-0.3-0.5
Patch foraging indifference point 0 sec6.410.311.53.43.3-3.3-2.93.3-3.4-3.3-3.4-3.23.3-3.1-2.4
Patch foraging indifference point AUC0.10.20.50.10.1-0.0-0.60.1-0.7-0.0-0.6-0.40.4-0.7-0.1
Delay disc. indifference point, 0s delay0.60.61.10.90.9-0.9-1.10.7-0.7-0.7-0.5-0.70.8-0.9-0.2
Delay disc. indifference point, 16s delay0.20.20.9-0.3-0.30.30.2-0.30.40.30.30.6-0.50.50.9
Delay disc. indifference point, 2s delay0.91.12.80.91.0-0.9-1.20.8-1.0-0.8-1.0-0.51.0-1.11.7
Delay disc. indifference point, 24s delay0.90.91.3-1.1-1.11.10.9-1.00.91.00.80.8-1.10.9-0.4
Delay disc. indifference point, 4s delay0.50.52.00.60.6-0.6-1.40.2-0.3-0.1-0.3-0.30.7-0.91.2
Delay disc. indifference point, 8s delay0.30.30.60.50.5-0.5-0.50.5-0.6-0.5-0.8-0.40.6-0.50.3
Indifference point function ln k1.11.52.91.61.6-1.6-0.91.7-0.8-1.7-0.8-1.01.1-0.5-0.5
Indifference point function log k1.11.52.91.61.6-1.6-0.91.7-0.8-1.7-0.8-1.01.1-0.5-0.5
Patch foraging total patch changes 0 sec5.18.29.33.03.0-3.0-2.73.0-3.1-2.9-3.0-2.82.9-2.8-2.0
Patch foraging total patch changes 12 sec2.43.15.11.51.5-1.4-1.81.4-2.3-1.4-2.0-1.91.8-2.0-1.8
Patch foraging total patch changes 18 sec3.24.15.41.81.8-1.7-2.11.8-2.3-1.8-2.0-2.22.2-2.1-2.3
Patch foraging total patch changes 24 sec0.50.61.50.80.8-0.7-1.20.6-0.9-0.6-0.7-0.60.7-1.00.5
Patch foraging total patch changes 6 sec1.42.12.91.51.5-1.5-1.11.5-1.7-1.5-1.6-1.41.3-1.2-1.4
Patch foraging time to switch 0 sec4.87.39.1-2.7-2.72.72.8-2.82.82.73.02.8-2.82.81.7
Patch foraging water rate 0 sec3.75.96.72.62.6-2.6-2.52.5-2.5-2.5-2.6-2.42.4-2.3-1.6
Patch foraging water rate 12 sec2.23.44.52.02.0-2.0-1.62.1-1.6-2.1-1.6-1.81.7-1.4-1.7
Patch foraging water rate 18 sec1.01.31.81.21.1-1.1-1.31.1-1.0-1.1-1.2-1.21.1-1.1-0.9
Patch foraging water rate 24 sec0.81.22.11.41.4-1.5-0.81.4-0.7-1.5-0.6-0.90.8-0.4-0.7
Patch foraging water rate 6 sec0.71.11.71.21.2-1.2-0.91.3-0.7-1.3-0.9-1.00.9-0.6-0.7
Seeking ratio, delayed vs. immediate footshock1.92.23.3-1.5-1.51.41.7-1.41.71.41.81.4-1.81.7-0.3
Distance traveled before self-admin0.50.50.8-0.8-0.90.90.7-0.80.70.80.40.7-0.60.60.4
Distance traveled after self-admin1.61.73.0-1.2-1.11.11.1-1.11.71.11.41.4-1.71.70.8
Extensor digitorum longus weight0.10.31.2-0.4-0.50.5-0.1-0.3-0.60.4-0.5-0.40.5-0.7-1.1
Bone: elastic displacement2.12.43.3-1.5-1.51.51.8-1.51.51.51.51.7-1.71.70.6
Bone: elastic work1.92.53.6-1.5-1.51.51.9-1.51.61.41.61.7-1.81.90.6
Bone: endosteal estimation1.63.55.31.51.4-1.4-2.01.5-2.3-1.5-2.0-2.12.1-2.3-1.9
Bone: endosteal perimeter2.45.17.02.01.9-1.9-2.32.1-2.6-2.0-2.3-2.52.5-2.6-2.1
Epididymis fat weight0.30.81.7-1.0-1.11.10.1-1.20.31.20.30.6-0.6-0.21.3
Delta time in closed arm before/after self-admin0.30.30.8-0.8-0.80.90.4-0.7-0.10.8-0.20.00.2-0.40.2
Delta time in open arm before/after self-admin3.02.93.71.71.6-1.6-1.91.7-1.7-1.7-1.7-1.81.6-1.7-1.6
Diff in mean of infusions in LGA sessions3.43.74.4-2.1-2.12.11.9-2.11.72.11.82.0-1.91.71.6
Delay discount exponential model param0.10.11.10.10.1-0.10.20.2-0.1-0.20.0-0.30.00.0-1.0
Extinction: sum of active levers before priming0.20.20.3-0.5-0.50.50.1-0.50.40.50.50.4-0.60.30.6
Active lever presses in extinction session 62.12.13.91.91.9-2.0-1.11.9-1.0-1.9-1.2-1.01.1-0.7-0.0
Bone: final force0.10.21.30.00.0-0.00.10.1-0.6-0.1-0.6-0.30.3-0.2-1.1
Bone: final moment0.30.42.20.30.2-0.2-0.20.4-0.8-0.4-0.8-0.60.5-0.5-1.5
Food consumed during 24 hour testing period3.44.15.52.12.2-2.2-2.02.3-1.5-2.3-1.3-2.21.8-1.6-2.3
Glucose0.00.10.4-0.1-0.00.0-0.0-0.10.30.00.10.3-0.20.30.7
Heart weight1.11.62.01.31.2-1.2-1.31.3-1.2-1.3-1.3-1.31.1-1.1-1.4
Delay discount hyperbolic model param0.10.11.3-0.1-0.10.10.50.00.1-0.00.2-0.1-0.20.3-1.1
Intermittent access intake day 1-15 change1.11.01.71.21.2-1.2-0.81.3-1.0-1.3-0.9-0.91.0-0.7-0.1
Intermittent access intake escalation1.41.42.31.41.4-1.4-0.91.5-1.2-1.5-1.1-1.01.1-0.8-0.2
Intermittent access intake escalation 20.60.60.80.80.8-0.8-0.70.9-0.9-0.9-0.8-0.70.8-0.7-0.0
Intermitt. access day 1 inactive lever presses0.90.91.3-1.0-1.01.00.8-1.11.01.10.81.0-1.00.71.1
Intermitt. access day 15 inactive lever presses0.10.10.2-0.1-0.10.10.2-0.10.50.10.50.3-0.50.4-0.1
Intermitt. access escalation Index0.30.31.10.40.4-0.4-0.50.5-0.4-0.5-0.5-0.50.3-0.4-1.0
Intermittent access day 1 total infusions0.70.81.40.70.7-0.7-1.10.7-0.9-0.7-0.9-1.00.9-0.9-1.2
Intermittent access day 15 total infusions1.41.52.01.31.3-1.4-1.21.4-1.2-1.4-1.2-1.21.2-1.0-0.8
Intermittent access terminal intake (last 3 days)1.21.31.51.21.2-1.2-1.21.2-1.2-1.2-1.1-1.21.2-1.0-1.0
Intermittent access total infusions0.50.60.80.70.7-0.7-0.90.8-0.8-0.8-0.8-0.90.8-0.7-0.8
Intermittent access day 1 locomotion0.00.00.20.00.0-0.00.2-0.00.20.00.1-0.0-0.10.2-0.4
Intermittent access day 15 total locomotion1.01.11.71.21.2-1.2-0.81.3-0.9-1.3-0.8-1.00.9-0.6-1.0
Intermittent access total locomotion0.30.40.40.70.7-0.7-0.60.6-0.6-0.6-0.6-0.70.6-0.5-0.7
Intermittent access standard deviation0.10.10.20.20.2-0.2-0.50.2-0.3-0.1-0.2-0.20.2-0.40.1
Left kidney weight1.02.85.51.41.3-1.3-2.11.2-1.9-1.2-1.9-1.91.9-2.3-0.9
Right kidney weight0.61.73.31.00.9-0.9-1.50.9-1.5-0.8-1.4-1.51.3-1.8-1.4
Cocaine induced anxiety2.02.32.7-1.6-1.61.61.7-1.61.51.61.51.5-1.51.50.9
Post-drug Anxiety0.60.71.1-0.9-0.90.91.1-0.80.70.80.70.8-0.70.60.8
Baseline Anxiety1.81.92.41.41.4-1.4-1.11.5-1.5-1.5-1.5-1.41.5-1.4-0.6
Tail length2.16.414.11.61.5-1.4-3.11.5-3.0-1.4-3.0-3.13.1-3.8-2.5
Length with tail0.51.85.70.50.4-0.3-1.90.3-1.6-0.2-1.7-1.51.6-2.4-0.8
Length without tail0.61.44.9-0.8-0.80.80.9-1.01.21.01.01.4-1.21.02.2
Times rat made contact with spout0.10.10.4-0.6-0.60.60.1-0.40.20.50.0-0.10.1-0.2-0.3
Lifetime Intake0.80.91.20.90.9-0.9-1.10.9-1.0-0.9-0.9-1.01.0-0.8-0.7
Liver weight, left0.40.61.3-1.1-1.11.10.4-1.10.41.20.30.4-0.4-0.10.1
Liver weight, right1.32.24.9-1.9-2.02.00.7-2.21.02.20.91.1-1.10.30.7
Locomotor activity1.32.14.41.41.4-1.4-1.21.5-1.1-1.5-1.2-1.71.4-1.2-2.1
Locomotor testing distance2.74.55.82.12.1-2.1-2.22.1-1.9-2.1-2.1-2.42.2-2.2-2.0
Locomotor testing rearing1.21.83.01.11.1-1.1-1.51.1-1.4-1.0-1.4-1.61.6-1.7-1.3
Locomotion in novel chamber0.81.01.61.21.2-1.2-0.71.2-0.5-1.3-0.9-1.00.8-0.4-0.9
Locomotion in novel chamber post-restriction2.22.64.82.02.0-2.0-1.12.2-1.4-2.2-1.5-1.11.3-0.90.6
Fecal boli incidents, locomotor time 10.70.71.21.11.1-1.1-0.71.0-0.4-1.0-0.6-0.80.4-0.5-1.1
Change in fecal boli incidents, locomotor task1.71.62.0-1.3-1.31.31.2-1.31.11.31.21.4-1.31.21.4
Time >=10cm from walls, locomotor time 11.31.32.11.41.4-1.4-1.21.4-0.9-1.4-1.1-0.80.8-0.70.3
Bouts of movement, locomotor time 10.00.00.30.20.2-0.2-0.50.00.0-0.00.10.0-0.1-0.10.3
Total resting periods, locomotor time 10.10.10.20.00.0-0.00.0-0.10.40.10.50.3-0.40.40.2
Rest time, locomotor task time 10.80.81.5-0.6-0.50.50.5-0.91.20.91.11.1-1.11.01.2
Distance moved, locomotor task time 11.01.12.10.50.5-0.5-0.90.7-1.4-0.7-1.4-1.21.4-1.2-1.5
Vertical activity count, locomotor time 11.61.73.00.90.9-0.9-0.81.2-1.7-1.1-1.7-1.41.6-1.4-1.3
Time >=10cm from walls, locomotor time 20.80.92.01.11.1-1.1-1.40.8-0.8-0.8-0.8-0.80.7-1.00.1
Bouts of movement, locomotor time 20.40.40.70.50.6-0.5-0.90.5-0.7-0.4-0.5-0.40.8-0.80.8
Total resting periods, locomotor time 20.20.21.40.30.3-0.3-0.50.2-0.4-0.1-0.2-0.10.5-0.51.2
Rest time, locomotor task time 22.93.34.6-2.0-2.01.92.1-1.91.81.91.71.8-1.81.80.7
Distance moved, locomotor task time 23.43.96.22.12.0-2.0-2.51.9-2.1-1.8-2.0-2.02.0-2.1-0.8
Vertical activity count, locomotor time 22.52.84.31.51.4-1.4-1.71.4-2.1-1.4-1.9-1.81.9-1.9-1.3
Light reinforcement 11.83.24.3-2.0-2.02.01.8-2.11.72.11.81.7-1.71.50.7
Light reinforcement 20.10.10.3-0.2-0.20.20.5-0.30.50.30.40.3-0.50.5-0.3
Bone: marrow area1.32.94.81.31.2-1.2-1.91.3-2.2-1.3-1.9-1.91.9-2.1-1.8
Bone: maximum diameter2.85.27.82.02.0-2.0-2.12.1-2.8-2.0-2.5-2.42.4-2.5-2.4
Bone: maximum force0.30.62.40.50.4-0.4-0.20.5-1.0-0.5-1.0-0.80.7-0.6-1.6
Bone: maximum moment0.61.03.40.70.6-0.6-0.50.8-1.2-0.8-1.2-1.01.0-0.9-1.8
Mean time between licks in bursts4.86.711.12.42.3-2.3-3.32.2-2.8-2.2-2.7-2.82.9-3.3-1.4
Mean num. licks in bursts5.06.07.52.62.6-2.6-2.22.7-2.2-2.7-2.1-2.62.4-2.2-2.2
Cd content in liver0.40.40.8-0.8-0.90.90.5-0.90.30.90.20.5-0.50.2-0.4
Co content in liver1.51.82.71.11.1-1.1-1.71.1-1.2-1.1-1.2-1.51.5-1.6-1.4
Cu content in liver0.50.61.70.70.7-0.7-1.30.5-0.6-0.5-0.8-0.90.9-1.20.2
Fe content in liver0.10.11.1-0.2-0.30.30.1-0.20.30.2-0.10.3-0.20.11.1
K content in liver0.10.10.1-0.3-0.30.30.3-0.20.10.20.40.0-0.0-0.00.1
Mg content in liver0.20.20.30.50.5-0.5-0.50.4-0.6-0.4-0.4-0.40.5-0.50.1
Mn content in liver1.92.13.7-1.2-1.21.21.7-1.21.51.21.91.7-1.71.80.7
Na content in liver0.30.30.90.70.7-0.7-0.40.7-0.3-0.7-0.1-0.20.4-0.31.0
Rb content in liver1.41.82.51.21.2-1.2-1.21.4-1.3-1.3-1.3-1.61.5-1.4-1.5
Se content in liver5.16.38.1-2.5-2.42.42.4-2.52.62.52.92.7-2.72.51.9
Sr content in liver0.00.00.10.10.1-0.10.20.10.2-0.10.30.2-0.30.40.2
Zn content in liver5.86.47.42.72.7-2.7-2.62.7-2.5-2.6-2.7-2.52.6-2.5-1.3
Bone: minimum diameter0.61.12.60.40.3-0.3-1.20.4-1.4-0.3-1.3-1.21.3-1.6-1.4
Time in familiar zone, hab. session 10.10.00.1-0.3-0.30.3-0.1-0.20.10.30.10.00.0-0.1-0.3
Time in novel zone, hab. session 10.10.10.2-0.3-0.30.30.5-0.40.20.40.10.3-0.30.20.2
Total zone transitions, hab. session 10.10.10.20.40.4-0.40.30.4-0.1-0.5-0.1-0.10.10.2-0.5
Total locomotion distance, hab. session 10.50.71.5-1.0-1.01.10.5-1.20.61.20.50.6-0.60.10.8
Locomotion velocity, hab. session 10.20.30.7-0.7-0.70.70.3-0.80.30.90.30.4-0.40.00.5
Time in familiar zone, hab. session 22.52.66.21.31.2-1.2-1.41.5-1.7-1.4-1.5-1.91.8-1.6-2.5
Time in novel zone, hab. session 21.31.34.5-0.6-0.60.60.7-0.91.20.91.11.3-1.41.12.1
Total zone transitions, hab. session 21.01.32.51.51.6-1.6-1.11.3-1.0-1.4-0.9-0.80.7-0.7-0.1
Total locomotion distance, hab. session 20.10.10.4-0.2-0.20.2-0.5-0.4-0.20.5-0.1-0.20.0-0.60.3
Locomotion velocity, hab. session 20.10.20.5-0.3-0.40.4-0.4-0.6-0.00.6-0.00.0-0.1-0.50.7
Novel to familiar place preference ratio0.10.11.50.10.1-0.2-0.3-0.10.10.1-0.00.3-0.20.11.2
Novelty place preference0.20.21.60.10.1-0.1-0.3-0.20.30.20.10.4-0.30.11.3
Time in novel zone, NPP test0.10.11.10.30.3-0.3-0.50.10.0-0.1-0.10.1-0.1-0.11.0
Total zone transitions, NPP test0.10.10.20.40.5-0.5-0.30.30.1-0.40.2-0.0-0.20.10.2
Total locomotion distance, NPP test1.01.33.2-1.1-1.11.10.2-1.51.01.51.01.1-1.20.41.8
Locomotion velocity, NPP test1.62.34.7-1.4-1.41.50.5-1.81.41.81.41.4-1.60.82.2
Intraocular pressure0.30.41.00.90.9-0.9-0.11.0-0.5-1.0-0.4-0.50.4-0.1-0.2
Delta distance traveled before/after self-admin0.10.10.10.30.3-0.3-0.20.30.2-0.30.2-0.0-0.20.30.1
Delta ambulatory time before/after self-admin0.10.20.60.30.4-0.4-0.10.30.4-0.30.40.1-0.30.50.8
Parametrial fat weight0.40.81.7-1.2-1.31.30.7-1.20.21.30.10.6-0.50.10.5
Pavlov. Cond. lever latency1.72.23.1-1.4-1.41.41.4-1.51.31.51.21.8-1.61.51.7
Pavlov. Cond. magazine entry latency3.54.55.42.22.1-2.1-2.22.1-2.1-2.1-2.2-2.32.2-2.3-1.5
Pavlov. Cond. change in total contacts1.11.12.01.21.2-1.2-1.41.0-0.9-1.0-0.9-1.11.1-1.2-0.3
Pavlov. Cond. index score3.84.86.52.12.1-2.1-2.22.2-2.1-2.1-2.1-2.52.4-2.4-2.0
Pavlov. Cond. latency score3.74.76.32.12.1-2.1-2.22.2-2.0-2.1-2.1-2.52.3-2.3-1.9
Pavlov. Cond. lever contacts1.72.13.21.31.3-1.3-1.51.4-1.2-1.4-1.2-1.81.6-1.6-1.6
Pavlov. Cond. magazine entry number4.25.26.2-2.3-2.32.32.3-2.32.22.32.32.5-2.42.31.6
Pavlov. Cond. intertrial magazine entries2.22.64.0-1.6-1.61.61.3-1.61.81.62.01.7-1.81.70.9
Pavlov. Cond. lever-magazine prob. diff.3.13.85.31.91.8-1.8-2.01.9-1.8-1.9-1.8-2.32.1-2.1-1.9
Pavlov. Cond. response bias1.62.02.91.31.3-1.3-1.41.3-1.3-1.3-1.2-1.71.5-1.6-1.6
Pavlov. Cond. lever latency20.227.331.4-5.6-5.65.55.6-5.35.45.35.55.2-5.25.12.6
Pavlov. Cond. magazine entry latency5.36.17.62.82.7-2.7-2.22.7-2.7-2.7-2.7-2.32.4-2.1-1.3
Pavlov. Cond. change in total contacts13.618.823.54.84.8-4.8-4.84.5-4.4-4.5-4.5-4.14.2-4.1-1.5
Pavlov. Cond. index score16.020.524.44.94.9-4.9-4.74.7-4.8-4.7-4.8-4.44.5-4.3-2.0
Pavlov. Cond. latency score14.417.921.64.64.6-4.6-4.44.4-4.5-4.4-4.5-4.04.2-4.0-1.8
Pavlov. Cond. lever contacts21.329.133.35.85.7-5.7-5.75.5-5.7-5.5-5.7-5.35.4-5.3-2.7
Pavlov. Cond. magazine entry number7.79.512.6-3.5-3.53.53.1-3.33.23.33.12.8-2.92.71.2
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.3-0.40.4-0.4-0.3-0.00.3-0.1-0.40.3-0.7-0.4
Pavlov. Cond. lever-magazine prob. diff.14.718.722.34.74.7-4.7-4.64.4-4.6-4.4-4.6-4.14.3-4.2-1.7
Pavlov. Cond. response bias21.929.834.35.95.8-5.8-5.65.6-5.7-5.6-5.8-5.45.5-5.3-3.0
Time in closed arm before self-admin1.01.23.21.41.4-1.4-0.51.3-0.4-1.4-0.3-0.80.4-0.1-1.8
Time in closed arm after self-admin0.80.81.8-0.7-0.60.61.4-0.61.00.61.10.7-0.91.2-0.7
Time in open arm before self-admin3.84.18.8-2.1-2.12.11.5-2.11.82.11.62.1-1.61.53.0
Time in open arm after self-admin0.60.61.50.40.3-0.3-1.10.4-1.1-0.4-1.2-0.81.0-1.20.1
Bone: periosteal estimation1.63.35.41.51.4-1.4-1.91.5-2.3-1.4-2.1-2.01.9-2.2-2.0
Bone: periosteal perimeter2.44.05.41.71.6-1.6-1.91.8-2.2-1.8-2.1-2.32.2-2.2-2.3
Bone: post-yield work0.91.24.30.80.7-0.7-0.41.0-1.3-1.0-1.3-1.21.2-0.9-2.1
Progressive ratio test 1 active lever presses0.50.60.9-0.7-0.70.70.7-0.70.70.70.80.8-0.70.80.9
Progressive ratio test 1 breakpoint0.40.40.7-0.7-0.70.70.6-0.70.60.70.60.7-0.60.60.8
Progressive ratio test 1 inactive lever presses0.10.10.10.20.2-0.2-0.40.2-0.3-0.2-0.4-0.20.3-0.30.2
Progressive ratio test 2 active lever presses1.11.21.61.11.0-1.0-1.21.1-1.3-1.1-1.2-1.11.2-1.1-0.4
Progressive ratio test 2 breakpoint1.11.31.71.11.1-1.1-1.31.1-1.3-1.1-1.2-1.21.3-1.2-0.5
Progressive ratio test 2 inactive lever presses0.60.71.40.80.8-0.8-0.80.9-0.8-0.9-0.8-0.90.7-0.6-1.2
Incentive Sensitization - Responses3.13.13.91.71.7-1.7-2.01.7-2.0-1.7-1.9-1.81.9-1.8-1.0
Incentive Sensitization - Breakpoint3.03.13.71.71.7-1.7-1.91.8-1.9-1.8-1.8-1.81.8-1.8-1.1
Sum of active levers in priming session hrs 5-60.00.00.1-0.0-0.00.00.0-0.10.20.10.30.1-0.40.1-0.2
Progressive ratio0.00.00.10.30.3-0.3-0.10.20.0-0.2-0.1-0.1-0.00.10.1
Food seeking constrained by brief footshock1.31.62.81.21.2-1.2-1.71.1-1.4-1.1-1.4-1.31.3-1.6-0.3
Seeking ratio, punishment vs. effort0.70.81.90.60.6-0.6-1.20.6-1.2-0.6-1.1-1.01.1-1.4-0.3
Retroperitoneal fat weight2.16.813.3-3.4-3.53.61.7-3.61.53.61.52.0-1.80.61.9
Reaction time number correct0.10.10.20.40.4-0.50.10.40.4-0.40.20.0-0.30.5-0.3
Reaction time mean minus median1.01.31.91.01.0-1.0-1.20.9-1.2-0.9-1.4-1.31.3-1.3-0.6
Reaction time mean minus median AUC1.21.61.91.31.3-1.3-1.31.2-1.2-1.2-1.3-1.41.3-1.2-1.0
Reaction time num false alarms1.72.33.1-1.8-1.81.81.5-1.71.31.71.51.4-1.41.10.8
Reaction time num false alarms AUC1.11.51.9-1.4-1.41.41.1-1.41.21.41.41.2-1.21.00.8
Reaction time trials correct on left0.10.10.20.40.4-0.50.10.40.4-0.40.20.0-0.30.5-0.3
Reaction time trials on left0.10.10.20.40.4-0.40.10.40.5-0.40.20.0-0.30.5-0.3
Reaction time mean0.60.81.5-1.1-1.11.20.8-1.20.51.20.30.8-0.70.40.7
Reaction time mean AUC1.11.52.3-1.4-1.41.41.2-1.50.91.50.71.2-1.10.90.9
Median of all reaction times1.41.92.8-1.6-1.61.61.4-1.71.01.70.81.4-1.31.01.1
Reaction time omissions0.30.41.3-0.6-0.60.60.3-0.70.40.70.20.6-0.50.21.1
Reaction time false alarm rate1.31.82.7-1.6-1.61.61.2-1.61.01.61.31.3-1.20.91.0
Reaction time premature initiation rate2.43.35.61.31.2-1.2-1.81.1-2.3-1.1-2.3-2.12.2-2.4-1.9
Reaction time premature initiations2.13.04.11.51.4-1.4-1.61.3-1.9-1.3-2.0-1.91.9-1.9-2.0
Std. dev. reaction times0.30.41.10.30.2-0.2-0.70.2-0.8-0.1-1.0-0.70.8-1.0-0.0
Reaction time trials completed0.10.10.20.40.4-0.40.10.40.5-0.40.20.0-0.30.5-0.3
Reaction time trials AUC0.10.10.20.40.4-0.40.00.40.4-0.40.10.0-0.20.3-0.2
Run reversals in cocaine runway, females0.50.51.0-0.7-0.80.8-0.3-0.7-0.60.8-0.6-0.40.6-1.0-0.4
Run reversals in cocaine runway, males0.10.10.3-0.3-0.30.30.4-0.20.10.20.10.1-0.00.2-0.6
Latency to leave start box in cocaine runway3.33.611.5-1.8-1.81.81.4-1.91.61.91.52.0-1.41.33.4
Latency to leave start box in cocaine runway, F2.32.610.5-1.5-1.51.61.0-1.61.11.71.11.6-1.00.73.2
Latency to leave start box in cocaine runway, M0.50.40.7-0.6-0.50.50.8-0.50.70.50.60.8-0.60.90.8
Std. dev. time between licks in bursts1.31.63.50.90.9-0.9-1.71.0-1.4-0.9-1.3-1.41.6-1.9-0.4
Total sessions with >9 infusions2.52.73.71.81.8-1.8-1.41.9-1.7-1.9-1.5-1.61.7-1.3-1.2
Short access day 1 total inactive lever presses0.40.40.7-0.7-0.70.60.8-0.70.70.60.70.6-0.70.70.1
Short access day 10 total inactive lever presses0.20.20.3-0.4-0.40.40.4-0.40.60.40.50.5-0.60.50.2
Short access day 1 total infusions2.12.33.21.51.5-1.5-1.81.5-1.6-1.5-1.5-1.51.6-1.5-1.0
Short access day 10 total infusions0.70.71.50.80.8-0.8-1.20.7-0.9-0.7-0.9-0.90.9-1.0-0.2
Short access total infusions0.70.81.20.80.8-0.7-1.10.8-1.0-0.8-0.9-0.91.0-1.0-0.5
Short access day 1 locomotion1.31.32.41.51.5-1.6-0.91.5-0.9-1.5-0.9-0.80.9-0.60.3
Short access day 10 total locomotion0.30.30.40.60.6-0.6-0.70.5-0.4-0.5-0.5-0.50.6-0.5-0.2
Short access total locomotion0.10.10.10.30.3-0.3-0.20.3-0.2-0.3-0.2-0.10.3-0.10.3
One hour access (0.3 mA shock)2.12.42.81.71.6-1.6-1.51.7-1.5-1.7-1.6-1.61.5-1.4-1.2
Compulsive drug intake0.10.10.20.30.4-0.40.10.30.1-0.40.10.1-0.20.20.5
One hour access (shock baseline)1.21.41.81.21.2-1.2-1.31.2-1.2-1.2-1.2-1.31.2-1.1-0.9
Social response proportion0.50.61.0-0.9-0.90.90.6-1.00.71.00.60.6-0.80.50.0
Social responses0.40.51.1-0.9-0.91.00.4-1.00.51.00.40.4-0.40.00.3
Social time4.35.67.3-2.2-2.12.12.2-2.42.72.42.62.5-2.72.42.2
Soleus weight0.20.51.2-0.5-0.60.6-0.4-0.5-0.70.6-0.6-0.60.6-1.1-1.1
Bone: stiffness0.10.10.3-0.5-0.50.50.4-0.5-0.30.5-0.40.1-0.0-0.1-0.4
Tibialis anterior weight0.10.51.00.40.4-0.4-0.70.4-0.9-0.4-0.9-0.80.8-1.0-0.6
Time to tail flick, vehicle, before self-admin0.60.66.8-0.1-0.10.10.10.1-0.2-0.10.2-0.50.00.1-2.6
Time to tail flick, vehicle, after self-admin1.92.12.61.61.6-1.6-1.21.6-1.3-1.6-1.4-1.41.3-1.1-1.3
Time to tail flick, test, before self-admin0.20.20.50.30.3-0.2-0.70.2-0.5-0.2-0.6-0.50.7-0.7-0.0
Time to tail flick, test, after self-admin0.20.20.70.20.2-0.2-0.80.1-0.3-0.0-0.4-0.40.6-0.80.6
Delta time to tail flick, vehicle, before/after SA1.51.52.91.41.4-1.4-1.01.3-1.0-1.3-1.2-0.51.1-0.91.7
Delta time to tail flick, test, before/after SA0.50.51.9-0.5-0.50.50.5-0.60.70.60.70.8-0.60.51.4
Tibia length1.43.86.32.42.5-2.5-1.82.4-1.7-2.5-1.6-1.61.6-1.2-0.7
Ambulatory time before self-admin0.90.91.2-1.0-1.01.01.0-0.91.00.90.91.1-1.01.00.7
Ambulatory time after self-admin1.82.04.0-1.1-1.11.01.2-1.11.91.01.71.5-1.92.01.0
Bone: tissue strength0.30.30.9-0.1-0.10.10.7-0.10.60.00.50.7-0.71.00.6
Total heroin consumption0.10.20.40.50.5-0.5-0.70.4-0.2-0.4-0.3-0.30.2-0.3-0.3
Bone: trabecular number0.71.14.6-1.0-1.01.01.4-0.70.60.70.80.5-0.81.2-2.1
Bone: trabecular spacing0.70.91.91.11.1-1.1-1.10.9-0.6-0.9-0.7-0.50.7-0.71.4
Bone: trabecular thickness0.20.32.1-0.5-0.50.50.4-0.30.10.30.1-0.2-0.1-0.0-1.5
Bone: trabecular tissue density1.21.62.9-1.5-1.51.50.8-1.71.01.70.81.1-0.90.41.6
Water consumed over 24 hours0.80.91.3-1.1-1.11.11.0-0.91.10.91.20.7-0.91.0-0.7
Number of responses in last shaping day0.50.51.60.40.4-0.4-0.70.4-0.7-0.4-0.8-0.90.8-0.9-1.2