Hub : Traits

Locomotion in novel chamber post-restriction

Locomotor2 was measured in the same animals as locomotor1, but after restriction to 85% of intial body weight.

Tags: Behavior · Locomotion

Project: u01_tom_jhou

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	14	46020357	47414802	1	1	3.05e-07	2.38e-01	1e+00	Arap2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.76	1	0	0	0	1e+00	Arap2
Body weight	1.96	1	0	0	0	1e+00	Arap2
Epididymis fat weight	3.75	1	0	0	0	1e+00	Arap2
Left kidney weight	2.23	1	0	0	0	1e+00	Arap2
Length without tail	3.72	1	0	0	0	1e+00	Arap2
Liver weight, left	2.89	1	0	0	0	1e+00	Arap2
Intraocular pressure	3.58	1	0	0	0	1e+00	Arap2
Extensor digitorum longus weight	2.63	1	0	0	0	1e+00	Arap2
Indifference point function ln k	4.05	1	0	0	0	1e+00	Arap2
Indifference point function log k	4.05	1	0	0	0	1e+00	Arap2
Delay discounting time to switch 0 sec	11	1	0	0	0	1e+00	Arap2
Delay discounting water rate 0 sec	7.22	1	0	0	0	1e+00	Arap2
Delay discounting water rate 18 sec	9.53	1	0	0	0	1e+00	Arap2
Light reinforcement 1	4.58	1	0	0	0	1e+00	Arap2
Reaction time number correct	2.87	1	0	0	0	1e+00	Arap2
Reaction time num false alarms	11.21	1	0	0	0	1e+00	Arap2
Reaction time num false alarms AUC	9.6	1	0	0	0	1e+00	Arap2
Reaction time trials correct on left	2.87	1	0	0	0	1e+00	Arap2
Reaction time trials on left	3.17	1	0	0	0	1e+00	Arap2
Reaction time mean	3.17	1	0	0	0	1e+00	Arap2
Reaction time mean AUC	4.8	1	0	0	0	1e+00	Arap2
Reaction time premature initiations	3.11	1	0	0	0	1e+00	Arap2
Reaction time trials completed	3.17	1	0	0	0	1e+00	Arap2
Reaction time trials AUC	3.34	1	0	0	0	1e+00	Arap2
Social response proportion	4.28	1	0	0	0	1e+00	Arap2
Saline control response	3.32	1	0	0	0	1e+00	Arap2
Pavlov. Cond. lever latency	3.47	1	0	0	0	1e+00	Arap2
Pavlov. Cond. change in total contacts	4.87	1	0	0	0	1e+00	Arap2
Pavlov. Cond. lever contacts	5.44	1	0	0	0	1e+00	Arap2
Pavlov. Cond. intertrial magazine entries	4.63	1	0	0	0	1e+00	Arap2
Pavlov. Cond. response bias	3.5	1	0	0	0	1e+00	Arap2
Conditioned reinforcement - inactives	16.81	1	0	0	0	1e+00	Arap2
Intermittent access intake day 1-15 change	14.58	1	0	0	0	1e+00	Arap2
Intermittent access intake escalation	10.8	1	0	0	0	1e+00	Arap2
Intermittent access intake escalation 2	10.05	1	0	0	0	1e+00	Arap2
Intermitt. access day 1 inactive lever presses	9.61	1	0	0	0	1e+00	Arap2
Intermitt. access day 15 inactive lever presses	9.76	1	0	0	0	1e+00	Arap2
Intermitt. access escalation Index	22.48	1	0	0	0	1e+00	Arap2
Intermittent access day 15 total infusions	4.4	1	0	0	0	1e+00	Arap2
Cocaine induced anxiety	3.99	1	0	0	0	1e+00	Arap2
Baseline Anxiety	9.21	1	0	0	0	1e+00	Arap2
Total sessions with >9 infusions	4.59	1	0	0	0	1e+00	Arap2
Short access day 1 total inactive lever presses	25.62	1	1	100	0	1e+00	Arap2
Short access day 10 total infusions	3.82	1	0	0	0	1e+00	Arap2
Short access total infusions	4.25	1	0	0	0	1e+00	Arap2
Short access total locomotion	8.55	1	0	0	0	1e+00	Arap2
One hour access (0.3 mA shock)	5.22	1	0	0	0	1e+00	Arap2
Locomotion velocity, session 1	3.58	1	0	0	0	1e+00	Arap2
Locomotion velocity, session 2	5.15	1	0	0	0	1e+00	Arap2
Locomotion distance, session 7	5.62	1	0	0	0	1e+00	Arap2
Condit. Reinf. active responses	16.38	1	0	0	0	1e+00	Arap2
Condit. Reinf. inactive responses	15.36	1	0	0	0	1e+00	Arap2
Incentive salience index mean	5.87	1	0	0	0	1e+00	Arap2
Condit. Reinf. lever presses	3.09	1	0	0	0	1e+00	Arap2
Total locomotion distance, hab. session 1	2.78	1	0	0	0	1e+00	Arap2
Locomotion velocity, hab. session 1	3.71	1	0	0	0	1e+00	Arap2
Total zone transitions, hab. session 2	6.36	1	0	0	0	1e+00	Arap2
Novelty place preference	3.97	1	0	0	0	1e+00	Arap2
Time in novel zone, NPP test	3.72	1	0	0	0	1e+00	Arap2
Total locomotion distance, NPP test	11.26	1	0	0	0	1e+00	Arap2
Locomotion velocity, NPP test	10.17	1	0	0	0	1e+00	Arap2
Pavlov. Cond. change in total contacts	14.48	1	0	0	0	1e+00	Arap2
Pavlov. Cond. intertrial magazine entries	13.25	1	0	0	0	1e+00	Arap2
Bone: cortical thickness	2.59	1	0	0	0	1e+00	Arap2
Bone: post-yield work	3.21	1	0	0	0	1e+00	Arap2
Bone: trabecular spacing	3.71	1	0	0	0	1e+00	Arap2
Active lever presses in extinction session 6	5.69	1	0	0	0	1e+00	Arap2
Time to tail flick, vehicle, before self-admin	6.98	1	0	0	0	1e+00	Arap2
Time to tail flick, test, after self-admin	8.18	1	0	0	0	1e+00	Arap2
Ambulatory time before self-admin	5.71	1	0	0	0	1e+00	Arap2
Total heroin consumption	9.88	1	0	0	0	1e+00	Arap2
Delay disc. indifference point, 2s delay	7.36	1	0	0	0	1e+00	Arap2
Change in fecal boli incidents, locomotor task	25.28	1	0	0	0	1e+00	Arap2
Vertical activity count, locomotor time 1	4.17	1	0	0	0	1e+00	Arap2
Distance moved, locomotor task time 2	4.66	1	0	0	0	1e+00	Arap2
Locomotion in novel chamber	8.93	1	0	0	0	1e+00	Arap2
Food seeking constrained by brief footshock	12.19	1	0	0	0	1e+00	Arap2
Seeking ratio, punishment vs. effort	3.3	1	0	0	0	1e+00	Arap2
Run reversals in cocaine runway, males	5.05	1	0	0	0	1e+00	Arap2
Cd content in liver	6.62	1	0	0	0	1e+00	Arap2
Co content in liver	3.63	1	0	0	0	1e+00	Arap2
Se content in liver	10	1	0	0	0	1e+00	Arap2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.23
Adipose	alternative TSS	0	0	1.25
Adipose	gene expression	0	0	1.18
Adipose	isoform ratio	0	0	1.22
Adipose	intron excision ratio	0	0	1.14
Adipose	mRNA stability	0	0	1.24
BLA	alternative polyA	0	0	1.29
BLA	alternative TSS	0	0	1.26
BLA	gene expression	0	0	1.23
BLA	isoform ratio	0	0	1.14
BLA	intron excision ratio	0	0	1.13
BLA	mRNA stability	0	0	1.23
Brain	alternative polyA	0	0	1.21
Brain	alternative TSS	0	0	1.24
Brain	gene expression	0	0	1.19
Brain	isoform ratio	0	0	1.09
Brain	intron excision ratio	0	0	1.16
Brain	mRNA stability	0	0	1.19
Eye	alternative polyA	0	0	1.24
Eye	alternative TSS	0	0	1.4
Eye	gene expression	0	0	1.14
Eye	isoform ratio	0	0	1.32
Eye	intron excision ratio	0	0	1.12
Eye	mRNA stability	0	0	1.19
IL	alternative polyA	0	0	1.12
IL	alternative TSS	0	0	1.07
IL	gene expression	0	0	1.17
IL	isoform ratio	0	0	1.16
IL	intron excision ratio	0	0	1.17
IL	mRNA stability	0	0	1.13
LHb	alternative polyA	0	0	1.01
LHb	alternative TSS	0	0	1.19
LHb	gene expression	0	0	1.2
LHb	isoform ratio	0	0	1.06
LHb	intron excision ratio	0	0	1.18
LHb	mRNA stability	0	0	1.24
Liver	alternative polyA	0	0	1.31
Liver	alternative TSS	0	0	1.22
Liver	gene expression	0	0	1.22
Liver	isoform ratio	0	0	1.17
Liver	intron excision ratio	0	0	1.13
Liver	mRNA stability	0	0	1.23
NAcc	alternative polyA	0	0	1.12
NAcc	alternative TSS	0	0	1.21
NAcc	gene expression	0	0	1.21
NAcc	isoform ratio	0	0	1.14
NAcc	intron excision ratio	0	0	1.13
NAcc	mRNA stability	1	0	1.23
OFC	alternative polyA	0	0	1.18
OFC	alternative TSS	0	0	1.3
OFC	gene expression	0	0	1.2
OFC	isoform ratio	0	0	1.17
OFC	intron excision ratio	0	0	1.11
OFC	mRNA stability	0	0	1.28
PL	alternative polyA	0	0	1.21
PL	alternative TSS	0	0	1.28
PL	gene expression	0	0	1.21
PL	isoform ratio	0	0	1.15
PL	intron excision ratio	0	0	1.15
PL	mRNA stability	0	0	1.23