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Locomotion in novel chamber post-restriction

Locomotor2 was measured in the same animals as locomotor1, but after restriction to 85% of intial body weight.

Tags: Behavior · Locomotion

Project: u01_tom_jhou

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 14 46020357 47414802 1 1 3.1e-07 0.24 1 100 Arap2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 1.8 1 0 0 0 1 Arap2
Body weight 2.0 1 0 0 0 1 Arap2
Epididymis fat weight 3.8 1 0 0 0 1 Arap2
Left kidney weight 2.2 1 0 0 0 1 Arap2
Length without tail 3.7 1 0 0 0 1 Arap2
Liver weight, left 2.9 1 0 0 0 1 Arap2
Intraocular pressure 3.6 1 0 0 0 1 Arap2
Extensor digitorum longus weight 2.6 1 0 0 0 1 Arap2
Indifference point function ln k 4.0 1 0 0 0 1 Arap2
Indifference point function log k 4.0 1 0 0 0 1 Arap2
Delay discounting time to switch 0 sec 11.0 1 0 0 0 1 Arap2
Delay discounting water rate 0 sec 7.2 1 0 0 0 1 Arap2
Delay discounting water rate 18 sec 9.5 1 0 0 0 1 Arap2
Light reinforcement 1 4.6 1 0 0 0 1 Arap2
Reaction time number correct 2.9 1 0 0 0 1 Arap2
Reaction time num false alarms 11.2 1 0 0 0 1 Arap2
Reaction time num false alarms AUC 9.6 1 0 0 0 1 Arap2
Reaction time trials correct on left 2.9 1 0 0 0 1 Arap2
Reaction time trials on left 3.2 1 0 0 0 1 Arap2
Reaction time mean 3.2 1 0 0 0 1 Arap2
Reaction time mean AUC 4.8 1 0 0 0 1 Arap2
Reaction time premature initiations 3.1 1 0 0 0 1 Arap2
Reaction time trials completed 3.2 1 0 0 0 1 Arap2
Reaction time trials AUC 3.3 1 0 0 0 1 Arap2
Social response proportion 4.3 1 0 0 0 1 Arap2
Saline control response 3.3 1 0 0 0 1 Arap2
Pavlov. Cond. lever latency 3.5 1 0 0 0 1 Arap2
Pavlov. Cond. change in total contacts 4.9 1 0 0 0 1 Arap2
Pavlov. Cond. lever contacts 5.4 1 0 0 0 1 Arap2
Pavlov. Cond. intertrial magazine entries 4.6 1 0 0 0 1 Arap2
Pavlov. Cond. response bias 3.5 1 0 0 0 1 Arap2
Conditioned reinforcement - inactives 16.8 1 0 0 0 1 Arap2
Intermittent access intake day 1-15 change 14.6 1 0 0 0 1 Arap2
Intermittent access intake escalation 10.8 1 0 0 0 1 Arap2
Intermittent access intake escalation 2 10.1 1 0 0 0 1 Arap2
Intermitt. access day 1 inactive lever presses 9.6 1 0 0 0 1 Arap2
Intermitt. access day 15 inactive lever presses 9.8 1 0 0 0 1 Arap2
Intermitt. access escalation Index 22.5 1 0 0 0 1 Arap2
Intermittent access day 15 total infusions 4.4 1 0 0 0 1 Arap2
Cocaine induced anxiety 4.0 1 0 0 0 1 Arap2
Baseline Anxiety 9.2 1 0 0 0 1 Arap2
Total sessions with >9 infusions 4.6 1 0 0 0 1 Arap2
Short access day 1 total inactive lever presses 25.6 1 1 100 0 1 Arap2
Short access day 10 total infusions 3.8 1 0 0 0 1 Arap2
Short access total infusions 4.2 1 0 0 0 1 Arap2
Short access total locomotion 8.6 1 0 0 0 1 Arap2
One hour access (0.3 mA shock) 5.2 1 0 0 0 1 Arap2
Locomotion velocity, session 1 3.6 1 0 0 0 1 Arap2
Locomotion velocity, session 2 5.2 1 0 0 0 1 Arap2
Locomotion distance, session 7 5.6 1 0 0 0 1 Arap2
Condit. Reinf. active responses 16.4 1 0 0 0 1 Arap2
Condit. Reinf. inactive responses 15.4 1 0 0 0 1 Arap2
Incentive salience index mean 5.9 1 0 0 0 1 Arap2
Condit. Reinf. lever presses 3.1 1 0 0 0 1 Arap2
Total locomotion distance, hab. session 1 2.8 1 0 0 0 1 Arap2
Locomotion velocity, hab. session 1 3.7 1 0 0 0 1 Arap2
Total zone transitions, hab. session 2 6.4 1 0 0 0 1 Arap2
Novelty place preference 4.0 1 0 0 0 1 Arap2
Time in novel zone, NPP test 3.7 1 0 0 0 1 Arap2
Total locomotion distance, NPP test 11.3 1 0 0 0 1 Arap2
Locomotion velocity, NPP test 10.2 1 0 0 0 1 Arap2
Pavlov. Cond. change in total contacts 14.5 1 0 0 0 1 Arap2
Pavlov. Cond. intertrial magazine entries 13.2 1 0 0 0 1 Arap2
Bone: cortical thickness 2.6 1 0 0 0 1 Arap2
Bone: post-yield work 3.2 1 0 0 0 1 Arap2
Bone: trabecular spacing 3.7 1 0 0 0 1 Arap2
Active lever presses in extinction session 6 5.7 1 0 0 0 1 Arap2
Time to tail flick, vehicle, before self-admin 7.0 1 0 0 0 1 Arap2
Time to tail flick, test, after self-admin 8.2 1 0 0 0 1 Arap2
Ambulatory time before self-admin 5.7 1 0 0 0 1 Arap2
Total heroin consumption 9.9 1 0 0 0 1 Arap2
Delay disc. indifference point, 2s delay 7.4 1 0 0 0 1 Arap2
Change in fecal boli incidents, locomotor task 25.3 1 0 0 0 1 Arap2
Vertical activity count, locomotor time 1 4.2 1 0 0 0 1 Arap2
Distance moved, locomotor task time 2 4.7 1 0 0 0 1 Arap2
Locomotion in novel chamber 8.9 1 0 0 0 1 Arap2
Food seeking constrained by brief footshock 12.2 1 0 0 0 1 Arap2
Seeking ratio, punishment vs. effort 3.3 1 0 0 0 1 Arap2
Run reversals in cocaine runway, males 5.0 1 0 0 0 1 Arap2
Cd content in liver 6.6 1 0 0 0 1 Arap2
Co content in liver 3.6 1 0 0 0 1 Arap2
Se content in liver 10.0 1 0 0 0 1 Arap2

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.2
Adipose alternative TSS 0 0.000 1.2
Adipose gene expression 0 0.000 1.2
Adipose isoform ratio 0 0.000 1.2
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.2
BLA alternative polyA 0 0.000 1.3
BLA alternative TSS 0 0.000 1.3
BLA gene expression 0 0.000 1.2
BLA isoform ratio 0 0.000 1.1
BLA intron excision ratio 0 0.000 1.1
BLA mRNA stability 0 0.000 1.2
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.2
Brain gene expression 0 0.000 1.2
Brain isoform ratio 0 0.000 1.1
Brain intron excision ratio 0 0.000 1.2
Brain mRNA stability 0 0.000 1.2
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.1
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.1
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.1
IL alternative TSS 0 0.000 1.1
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.2
IL mRNA stability 0 0.000 1.1
LHb alternative polyA 0 0.000 1.0
LHb alternative TSS 0 0.000 1.2
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.1
LHb intron excision ratio 0 0.000 1.2
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.3
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.2
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.1
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.2
NAcc isoform ratio 0 0.000 1.1
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 1 0.044 1.2
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.2
OFC isoform ratio 0 0.000 1.2
OFC intron excision ratio 0 0.000 1.1
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.2
PL alternative TSS 0 0.000 1.3
PL gene expression 0 0.000 1.2
PL isoform ratio 0 0.000 1.1
PL intron excision ratio 0 0.000 1.2
PL mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.