Distance moved, locomotor task time 1

Total distance (cm) moved in the 15 min session in time1

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr8 108585012 109845634 1 1 5.63e-09 1.48e-01 8.38e-01 Klhdc8b

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 18.84 1 1 100 0 1e+00 Klhdc8b
BMI without tail 27.06 1 1 100 0 1e+00 Klhdc8b
Body weight 20.7 1 1 100 0 1e+00 Klhdc8b
Heart weight 17.24 1 0 0 0 1e+00 Klhdc8b
Left kidney weight 27.97 1 1 100 0 1e+00 Klhdc8b
Right kidney weight 10.32 1 1 100 0 1e+00 Klhdc8b
Tail length 8.12 1 0 0 0 1e+00 Klhdc8b
Length with tail 9.26 1 1 100 0 1e+00 Klhdc8b
Length without tail 2.4 1 0 0 0 1e+00 Klhdc8b
Liver weight, left 13.45 1 0 0 0 1e+00 Klhdc8b
Liver weight, right 3.23 1 0 0 0 1e+00 Klhdc8b
Retroperitoneal fat weight 6.24 1 0 0 0 1e+00 Klhdc8b
Soleus weight 8.84 1 0 0 0 1e+00 Klhdc8b
Tibialis anterior weight 1.33 1 0 0 0 1e+00 Klhdc8b
Tibia length 10.96 1 1 100 0 1e+00 Klhdc8b
Number of licking bursts 24.53 1 1 100 0 1e+00 Klhdc8b
Food consumed during 24 hour testing period 9.01 1 0 0 0 1e+00 Klhdc8b
Times rat made contact with spout 5.33 1 0 0 0 1e+00 Klhdc8b
Mean time between licks in bursts 5.14 1 0 0 0 1e+00 Klhdc8b
Mean num. licks in bursts 11.71 1 0 0 0 1e+00 Klhdc8b
Water consumed over 24 hours 8.34 1 0 0 0 1e+00 Klhdc8b
Patch foraging indifference point 0 sec 8.18 1 0 0 0 1e+00 Klhdc8b
Patch foraging indifference point AUC 4.75 1 0 0 0 1e+00 Klhdc8b
Indifference point function ln k 36.38 1 1 100 0 1e+00 Klhdc8b
Indifference point function log k 36.38 1 1 100 0 1e+00 Klhdc8b
Patch foraging total patch changes 0 sec 8.89 1 0 0 0 1e+00 Klhdc8b
Patch foraging total patch changes 18 sec 5.31 1 0 0 0 1e+00 Klhdc8b
Patch foraging total patch changes 24 sec 6.54 1 0 0 0 1e+00 Klhdc8b
Patch foraging time to switch 0 sec 6.73 1 0 0 0 1e+00 Klhdc8b
Patch foraging water rate 6 sec 2.67 1 0 0 0 1e+00 Klhdc8b
Locomotor activity 57.78 1 1 100 0 1e+00 Klhdc8b
Locomotor testing distance 64.52 1 1 100 0 1e+00 Klhdc8b
Locomotor testing rearing 3.38 1 0 0 0 1e+00 Klhdc8b
Light reinforcement 2 7.12 1 0 0 0 1e+00 Klhdc8b
Reaction time number correct 18.64 1 1 100 0 1e+00 Klhdc8b
Reaction time num false alarms 5.75 1 0 0 0 1e+00 Klhdc8b
Reaction time num false alarms AUC 6.59 1 0 0 0 1e+00 Klhdc8b
Reaction time trials correct on left 18.64 1 1 100 0 1e+00 Klhdc8b
Reaction time trials on left 19.51 1 1 100 0 1e+00 Klhdc8b
Reaction time mean 3.45 1 0 0 0 1e+00 Klhdc8b
Reaction time mean AUC 9.44 1 0 0 0 1e+00 Klhdc8b
Median of all reaction times 10.54 1 0 0 0 1e+00 Klhdc8b
Reaction time omissions 23.75 1 1 100 0 1e+00 Klhdc8b
Reaction time false alarm rate 20.24 1 1 100 0 1e+00 Klhdc8b
Reaction time premature initiations 5.21 1 0 0 0 1e+00 Klhdc8b
Std. dev. reaction times 3.82 1 0 0 0 1e+00 Klhdc8b
Reaction time trials completed 19.51 1 1 100 0 1e+00 Klhdc8b
Reaction time trials AUC 20.65 1 1 100 0 1e+00 Klhdc8b
Social response proportion 4.26 1 0 0 0 1e+00 Klhdc8b
Conditioned locomotion 28.4 1 1 100 0 1e+00 Klhdc8b
Cocaine response after cond. not corrected 16.6 1 0 0 0 1e+00 Klhdc8b
Cocaine response before conditioning 38.66 1 1 100 0 1e+00 Klhdc8b
Saline control response 4.21 1 0 0 0 1e+00 Klhdc8b
Condit. Reinf. inactive responses 3.79 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. magazine entry latency 5.33 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. magazine entry number 30 1 1 100 0 1e+00 Klhdc8b
Pavlov. Cond. intertrial magazine entries 7.56 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. response bias 5.18 1 0 0 0 1e+00 Klhdc8b
Conditioned reinforcement - inactives 16.77 1 0 0 0 1e+00 Klhdc8b
Conditioned locomotion 4.19 1 0 0 0 1e+00 Klhdc8b
Intermitt. access day 1 inactive lever presses 13.69 1 0 0 0 1e+00 Klhdc8b
Intermitt. access day 15 inactive lever presses 30.78 1 1 100 0 1e+00 Klhdc8b
Intermittent access day 1 total infusions 7.02 1 0 0 0 1e+00 Klhdc8b
Intermittent access day 15 total infusions 14.21 1 0 0 0 1e+00 Klhdc8b
Intermittent access terminal intake (last 3 days) 24.03 1 0 0 0 1e+00 Klhdc8b
Intermittent access total infusions 15.45 1 0 0 0 1e+00 Klhdc8b
Intermittent access day 1 locomotion 11.5 1 0 0 0 1e+00 Klhdc8b
Intermittent access total locomotion 3.46 1 0 0 0 1e+00 Klhdc8b
Intermittent access standard deviation 16.8 1 0 0 0 1e+00 Klhdc8b
Cocaine induced anxiety 13.65 1 0 0 0 1e+00 Klhdc8b
Lifetime Intake 9.49 1 0 0 0 1e+00 Klhdc8b
Progressive ratio test 1 inactive lever presses 16.55 1 0 0 0 1e+00 Klhdc8b
Progressive ratio test 2 active lever presses 4.8 1 0 0 0 1e+00 Klhdc8b
Progressive ratio test 2 inactive lever presses 10.83 1 0 0 0 1e+00 Klhdc8b
Total sessions with >9 infusions 16 1 0 0 0 1e+00 Klhdc8b
Short access day 1 total inactive lever presses 13.04 1 0 0 0 1e+00 Klhdc8b
Short access day 10 total inactive lever presses 101.65 1 1 100 0 1e+00 Klhdc8b
Short access day 10 total infusions 13.17 1 0 0 0 1e+00 Klhdc8b
Short access total infusions 5.11 1 0 0 0 1e+00 Klhdc8b
Short access day 1 locomotion 11.78 1 0 0 0 1e+00 Klhdc8b
Short access total locomotion 3.87 1 0 0 0 1e+00 Klhdc8b
One hour access (0.3 mA shock) 13.43 1 0 0 0 1e+00 Klhdc8b
One hour access (shock baseline) 8.36 1 0 0 0 1e+00 Klhdc8b
Context. condit. distance diff. score 3.61 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 1 23.98 1 1 100 0 1e+00 Klhdc8b
Locomotion velocity, session 2 10 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 2 33.15 1 1 100 0 1e+00 Klhdc8b
Locomotion velocity, session 3 17.14 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 3 14.51 1 0 0 0 1e+00 Klhdc8b
Stereotopy head waving duration, day 3 6.96 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, session 8 9.36 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 8 52.78 1 1 100 0 1e+00 Klhdc8b
Degree of sensitization distance 24.75 1 0 0 0 1e+00 Klhdc8b
Condit. Reinf. active minus inactive responses 35.59 1 1 100 0 1e+00 Klhdc8b
Condit. Reinf. active-inactive response ratio 25.6 1 1 100 0 1e+00 Klhdc8b
Condit. Reinf. active responses 18.23 1 0 0 0 1e+00 Klhdc8b
Incentive salience index mean 26.23 1 1 100 0 1e+00 Klhdc8b
Condit. Reinf. lever presses 10.81 1 0 0 0 1e+00 Klhdc8b
Time in familiar zone, hab. session 1 63.49 1 1 100 0 1e+00 Klhdc8b
Time in novel zone, hab. session 1 13.1 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, hab. session 1 37.38 1 1 100 0 1e+00 Klhdc8b
Total locomotion distance, hab. session 1 10.76 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, hab. session 1 10.22 1 0 0 0 1e+00 Klhdc8b
Time in familiar zone, hab. session 2 27.1 1 1 100 0 1e+00 Klhdc8b
Time in novel zone, hab. session 2 10.13 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, hab. session 2 69.58 1 1 100 0 1e+00 Klhdc8b
Total locomotion distance, hab. session 2 19.2 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, hab. session 2 21.15 1 1 100 0 1e+00 Klhdc8b
Novel to familiar place preference ratio 22.33 1 0 0 0 1e+00 Klhdc8b
Novelty place preference 20.99 1 0 0 0 1e+00 Klhdc8b
Time in novel zone, NPP test 17.06 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, NPP test 106.24 1 1 100 0 1e+00 Klhdc8b
Total locomotion distance, NPP test 47.64 1 1 100 0 1e+00 Klhdc8b
Locomotion velocity, NPP test 51.12 1 1 100 0 1e+00 Klhdc8b
Pavlov. Cond. change in total contacts 69.48 1 1 100 0 1e+00 Klhdc8b
Pavlov. Cond. index score 14.07 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. latency score 8.82 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. lever contacts 4.86 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. magazine entry number 12.23 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. lever-magazine prob. diff. 14.82 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. response bias 10.49 1 0 0 0 1e+00 Klhdc8b
Bone: cortical porosity 6.2 1 0 0 0 1e+00 Klhdc8b
Bone: endosteal estimation 4 1 0 0 0 1e+00 Klhdc8b
Bone: final force 4.4 1 0 0 0 1e+00 Klhdc8b
Bone: marrow area 3.15 1 0 0 0 1e+00 Klhdc8b
Bone: maximum diameter 3.26 1 0 0 0 1e+00 Klhdc8b
Bone: maximum force 7.19 1 0 0 0 1e+00 Klhdc8b
Bone: maximum moment 3.52 1 0 0 0 1e+00 Klhdc8b
Bone: periosteal estimation 3.04 1 0 0 0 1e+00 Klhdc8b
Bone: periosteal perimeter 2.96 1 0 0 0 1e+00 Klhdc8b
Bone: stiffness 13.41 1 0 0 0 1e+00 Klhdc8b
Bone: trabecular tissue density 3.12 1 0 0 0 1e+00 Klhdc8b
Delta time in closed arm before/after self-admin 12.84 1 0 0 0 1e+00 Klhdc8b
Extinction: sum of active levers before priming 5.93 1 0 0 0 1e+00 Klhdc8b
Active lever presses in extinction session 6 7.23 1 0 0 0 1e+00 Klhdc8b
Time in closed arm after self-admin 5.85 1 0 0 0 1e+00 Klhdc8b
Sum of active levers in priming session hrs 5-6 4.91 1 0 0 0 1e+00 Klhdc8b
Time to tail flick, vehicle, after self-admin 37.57 1 1 100 0 1e+00 Klhdc8b
Delta time to tail flick, vehicle, before/after SA 14.47 1 0 0 0 1e+00 Klhdc8b
Ambulatory time after self-admin 6.07 1 0 0 0 1e+00 Klhdc8b
Total heroin consumption 18.89 1 0 0 0 1e+00 Klhdc8b
Area under the delay curve 4.87 1 0 0 0 1e+00 Klhdc8b
Delay disc. indifference point, 0s delay 28.7 1 1 100 0 1e+00 Klhdc8b
Delay disc. indifference point, 16s delay 13.12 1 0 0 0 1e+00 Klhdc8b
Delay disc. indifference point, 4s delay 41.82 1 1 100 0 1e+00 Klhdc8b
Delay disc. indifference point, 8s delay 5.59 1 0 0 0 1e+00 Klhdc8b
Delay discount hyperbolic model param 5.02 1 0 0 0 1e+00 Klhdc8b
Fecal boli incidents, locomotor time 1 16.98 1 0 0 0 1e+00 Klhdc8b
Change in fecal boli incidents, locomotor task 4.32 1 0 0 0 1e+00 Klhdc8b
Time >=10cm from walls, locomotor time 1 7.65 1 0 0 0 1e+00 Klhdc8b
Bouts of movement, locomotor time 1 4.44 1 0 0 0 1e+00 Klhdc8b
Total resting periods, locomotor time 1 4.04 1 0 0 0 1e+00 Klhdc8b
Rest time, locomotor task time 1 22.55 1 0 0 0 1e+00 Klhdc8b
Vertical activity count, locomotor time 1 49.01 1 1 100 0 1e+00 Klhdc8b
Time >=10cm from walls, locomotor time 2 4.57 1 0 0 0 1e+00 Klhdc8b
Bouts of movement, locomotor time 2 19.85 1 0 0 0 1e+00 Klhdc8b
Total resting periods, locomotor time 2 20.22 1 0 0 0 1e+00 Klhdc8b
Rest time, locomotor task time 2 25.34 1 1 100 0 1e+00 Klhdc8b
Distance moved, locomotor task time 2 42.39 1 1 100 0 1e+00 Klhdc8b
Vertical activity count, locomotor time 2 54.92 1 1 100 0 1e+00 Klhdc8b
Weight adjusted by age 30.32 1 1 100 0 1e+00 Klhdc8b
Locomotion in novel chamber 3.85 1 0 0 0 1e+00 Klhdc8b
Progressive ratio 7.25 1 0 0 0 1e+00 Klhdc8b
Food seeking constrained by brief footshock 12.71 1 0 0 0 1e+00 Klhdc8b
Seeking ratio, punishment vs. effort 4.64 1 0 0 0 1e+00 Klhdc8b
Run reversals in cocaine runway, females 6.51 1 0 0 0 1e+00 Klhdc8b
Cd content in liver 20.17 1 0 0 0 1e+00 Klhdc8b
Fe content in liver 40.39 1 1 100 0 1e+00 Klhdc8b
K content in liver 12.22 1 0 0 0 1e+00 Klhdc8b
Mg content in liver 15.79 1 0 0 0 1e+00 Klhdc8b
Mn content in liver 5.99 1 0 0 0 1e+00 Klhdc8b
Na content in liver 16.36 1 0 0 0 1e+00 Klhdc8b
Rb content in liver 51.88 1 1 100 0 1e+00 Klhdc8b
Se content in liver 8.45 1 0 0 0 1e+00 Klhdc8b
Sr content in liver 22.41 1 0 0 0 1e+00 Klhdc8b
Zn content in liver 9.95 1 0 0 0 1e+00 Klhdc8b

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.06
Adipose alternative TSS 0 0 1.11
Adipose gene expression 0 0 1.07
Adipose isoform ratio 0 0 1.11
Adipose intron excision ratio 0 0 1.13
Adipose mRNA stability 0 0 1.08
BLA alternative polyA 0 0 1.07
BLA alternative TSS 0 0 1.23
BLA gene expression 0 0 1.14
BLA isoform ratio 0 0 1.18
BLA intron excision ratio 0 0 1.2
BLA mRNA stability 0 0 1.11
Brain alternative polyA 0 0 1.08
Brain alternative TSS 0 0 1.07
Brain gene expression 0 0 1.09
Brain isoform ratio 0 0 1.13
Brain intron excision ratio 0 0 1.12
Brain mRNA stability 0 0 1.1
Eye alternative polyA 0 0 1.01
Eye alternative TSS 0 0 1.31
Eye gene expression 0 0 1.14
Eye isoform ratio 0 0 1.08
Eye intron excision ratio 0 0 1.11
Eye mRNA stability 0 0 1.08
IL alternative polyA 0 0 0.92
IL alternative TSS 0 0 0.98
IL gene expression 0 0 1.1
IL isoform ratio 0 0 1.16
IL intron excision ratio 0 0 1.12
IL mRNA stability 0 0 1.11
LHb alternative polyA 0 0 1
LHb alternative TSS 0 0 1.18
LHb gene expression 0 0 1.08
LHb isoform ratio 0 0 1.04
LHb intron excision ratio 0 0 1.15
LHb mRNA stability 0 0 1.09
Liver alternative polyA 0 0 1.07
Liver alternative TSS 0 0 1.13
Liver gene expression 1 0 1.09
Liver isoform ratio 0 0 1.08
Liver intron excision ratio 0 0 1.04
Liver mRNA stability 0 0 1.05
NAcc alternative polyA 0 0 1.02
NAcc alternative TSS 0 0 1.17
NAcc gene expression 0 0 1.07
NAcc isoform ratio 0 0 1.12
NAcc intron excision ratio 0 0 1.15
NAcc mRNA stability 0 0 1.11
OFC alternative polyA 0 0 0.94
OFC alternative TSS 0 0 1.04
OFC gene expression 0 0 1.1
OFC isoform ratio 0 0 1.08
OFC intron excision ratio 0 0 1
OFC mRNA stability 0 0 1.11
PL alternative polyA 0 0 1.07
PL alternative TSS 0 0 1.09
PL gene expression 0 0 1.1
PL isoform ratio 0 0 1.12
PL intron excision ratio 0 0 1.12
PL mRNA stability 0 0 1.08
pVTA alternative polyA 0 0 1.02
pVTA alternative TSS 0 0 1.1
pVTA gene expression 0 0 1.1
pVTA isoform ratio 0 0 1.12
pVTA intron excision ratio 0 0 1.13
pVTA mRNA stability 0 0 1.1
RMTg alternative polyA 0 0 0.98
RMTg alternative TSS 0 0 1.21
RMTg gene expression 0 0 1.06
RMTg isoform ratio 0 0 1.12
RMTg intron excision ratio 0 0 1.08
RMTg mRNA stability 0 0 1.07