Hub : Traits

reaction_time_leftcorr

Trials completed in which the imperative stimulus was on the left side and the rat responded correctly in the last three 18-minute sessions for males and females [n]

Project: p50_david_dietz

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 97168285 98018334 1 1 2.1e-07 7.6e-05 0.59 98 Gtf2h1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
retroperitoneal_fat_g 1.4 1 0 0 0 1 Gtf2h1
dissection: UMAP 3 of all traits 1.8 1 0 0 0 1 Gtf2h1
dissection: PC 3 of all traits 2.2 1 0 0 0 1 Gtf2h1
dissection: PC 2 of all traits 2.0 1 0 0 0 1 Gtf2h1
os_mean 6.1 1 0 0 0 1 Gtf2h1
reaction_time_corr 18.7 1 1 100 0 1 Gtf2h1
delay_discounting_pc1800 3.1 1 0 0 0 1 Gtf2h1
pavca_mi_d1_prob_lev 2.9 1 0 0 0 1 Gtf2h1
pavca_mi_d1_avg_lev_lat 3.0 1 0 0 0 1 Gtf2h1
Trabecular tissue density 3.5 1 0 0 0 1 Gtf2h1
tautz: manual_mpc12 5.0 1 0 0 0 1 Gtf2h1
tautz: manual_mpc13 3.1 1 0 0 0 1 Gtf2h1
tautz: manual_spc5 3.1 1 0 0 0 1 Gtf2h1
The total number of resting periods in time1 4.4 1 0 0 0 1 Gtf2h1
Weight adjusted by age 8.0 1 0 0 0 1 Gtf2h1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.4
Adipose alternative TSS 0 0.000 1.5
Adipose gene expression 0 0.000 1.4
Adipose isoform ratio 0 0.000 1.4
Adipose intron excision ratio 0 0.000 1.4
Adipose mRNA stability 0 0.000 1.4
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.4
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.5
Brain alternative polyA 0 0.000 1.5
Brain alternative TSS 0 0.000 1.4
Brain gene expression 0 0.000 1.4
Brain isoform ratio 0 0.000 1.5
Brain intron excision ratio 0 0.000 1.5
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.5
Eye alternative TSS 0 0.000 1.0
Eye gene expression 0 0.000 1.3
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.4
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.5
IL alternative TSS 0 0.000 1.4
IL gene expression 0 0.000 1.5
IL isoform ratio 0 0.000 1.6
IL intron excision ratio 0 0.000 1.5
IL mRNA stability 0 0.000 1.6
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.5
LHb gene expression 0 0.000 1.5
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.4
Liver intron excision ratio 0 0.000 1.4
Liver mRNA stability 0 0.000 1.4
NAcc alternative polyA 0 0.000 1.6
NAcc alternative TSS 0 0.000 1.5
NAcc gene expression 0 0.000 1.5
NAcc isoform ratio 0 0.000 1.4
NAcc intron excision ratio 0 0.000 1.4
NAcc mRNA stability 0 0.000 1.6
NAcc2 alternative polyA 0 0.000 1.5
NAcc2 alternative TSS 0 0.000 1.4
NAcc2 gene expression 0 0.000 1.4
NAcc2 isoform ratio 0 0.000 1.4
NAcc2 intron excision ratio 0 0.000 1.4
NAcc2 mRNA stability 0 0.000 1.5
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.5
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.5
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.6
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.3
PL gene expression 0 0.000 1.5
PL isoform ratio 0 0.000 1.4
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 1 0.087 1.6
PL2 alternative polyA 0 0.000 1.6
PL2 alternative TSS 0 0.000 1.5
PL2 gene expression 0 0.000 1.4
PL2 isoform ratio 0 0.000 1.5
PL2 intron excision ratio 0 0.000 1.5
PL2 mRNA stability 0 0.000 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.