Hub : Traits

Locomotor activity

Activity in a novel 24 X 45 cm chamber in the 18-minute session for males and females [n beam breaks/18 min test]

Tags: Behavior · Locomotion

Project: p50_david_dietz

1 loci · 1 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	6	60576851	62029190	2	1	5.88e-08	4.47e-08	1.52e-89	Pnpla8

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Length with tail	4.7	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Length without tail	6.55	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Tibialis anterior weight	2.76	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Times rat made contact with spout	6.67	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Indifference point 0 sec	3.62	1	0	0	0	1e+00	Pnpla8
Delay discounting total patch changes 6 sec	4.38	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Delay discounting time to switch 0 sec	7.73	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Locomotor testing distance	15.33	2	2	200	0	1e+00	Pnpla8 ENSRNOG00000068595
Locomotor testing rearing	9.26	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Conditioned locomotion	8.95	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Condit. Reinf. active responses	5.66	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Incentive salience index mean	5.27	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Condit. Reinf. lever presses	4.44	1	0	0	0	1e+00	Pnpla8
Bone: connectivity density	3.77	1	0	0	0	1e+00	ENSRNOG00000068595
Bone: maximum diameter	3.42	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Run reversals in cocaine runway, females	7.11	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595
Co content in liver	7.08	2	0	0	0	1e+00	Pnpla8 ENSRNOG00000068595

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.6
Adipose	alternative TSS	0	0	1.51
Adipose	gene expression	1	0	1.54
Adipose	isoform ratio	0	0	1.6
Adipose	intron excision ratio	0	0	1.67
Adipose	mRNA stability	0	0	1.55
BLA	alternative polyA	0	0	1.53
BLA	alternative TSS	0	0	1.7
BLA	gene expression	1	0	1.63
BLA	isoform ratio	0	0	1.55
BLA	intron excision ratio	0	0	1.71
BLA	mRNA stability	0	0	1.69
Brain	alternative polyA	0	0	1.54
Brain	alternative TSS	0	0	1.57
Brain	gene expression	0	0	1.58
Brain	isoform ratio	0	0	1.63
Brain	intron excision ratio	0	0	1.66
Brain	mRNA stability	0	0	1.55
Eye	alternative polyA	0	0	1.46
Eye	alternative TSS	0	0	1.45
Eye	gene expression	0	0	1.62
Eye	isoform ratio	0	0	1.73
Eye	intron excision ratio	0	0	1.7
Eye	mRNA stability	0	0	1.57
IL	alternative polyA	0	0	1.57
IL	alternative TSS	0	0	1.91
IL	gene expression	0	0	1.6
IL	isoform ratio	0	0	1.48
IL	intron excision ratio	0	0	1.55
IL	mRNA stability	0	0	1.73
LHb	alternative polyA	0	0	1.55
LHb	alternative TSS	0	0	1.62
LHb	gene expression	0	0	1.64
LHb	isoform ratio	0	0	1.72
LHb	intron excision ratio	0	0	1.68
LHb	mRNA stability	0	0	1.69
Liver	alternative polyA	0	0	1.58
Liver	alternative TSS	0	0	1.44
Liver	gene expression	0	0	1.57
Liver	isoform ratio	0	0	1.51
Liver	intron excision ratio	0	0	1.49
Liver	mRNA stability	0	0	1.47
NAcc	alternative polyA	0	0	1.49
NAcc	alternative TSS	0	0	1.71
NAcc	gene expression	0	0	1.62
NAcc	isoform ratio	0	0	1.56
NAcc	intron excision ratio	0	0	1.58
NAcc	mRNA stability	0	0	1.63
OFC	alternative polyA	0	0	1.38
OFC	alternative TSS	0	0	1.81
OFC	gene expression	1	0	1.59
OFC	isoform ratio	0	0	1.49
OFC	intron excision ratio	0	0	1.74
OFC	mRNA stability	0	0	1.6
PL	alternative polyA	0	0	1.48
PL	alternative TSS	0	0	1.71
PL	gene expression	0	0	1.61
PL	isoform ratio	0	0	1.58
PL	intron excision ratio	0	0	1.57
PL	mRNA stability	0	0	1.59