Activity in a novel 24 X 45 cm chamber in the 18-minute session for males and females [n beam breaks/18 min test]
Project: p50_david_dietz
4 significantly associated models · 2 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 6 | 60576851 | 62029190 | 2 | 1 | 5.9e-08 | 4.5e-08 | 1.5e-89 | -1245 | Pnpla8 |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| dissection: UMAP 3 of all traits | 5.4 | 2 | 0 | 0 | 0.12 | 0.883 | Pnpla8 NA |
| dissection: PC 2 of all traits | 5.5 | 2 | 0 | 0 | -0.76 | 0.240 | Pnpla8 NA |
| TA weight in grams | 2.9 | 2 | 0 | 0 | -0.87 | 0.126 | Pnpla8 NA |
| Times rat made contact with spout | 6.7 | 2 | 0 | 0 | -0.25 | 0.750 | Pnpla8 NA |
| Average drop size | 5.8 | 2 | 0 | 0 | 0.00 | 1.000 | Pnpla8 NA |
| reaction_time_pinit_slope | 5.5 | 2 | 0 | 0 | 0.00 | 1.000 | Pnpla8 NA |
| ccp_trial_3_saline_dist_mm | 6.6 | 2 | 0 | 0 | 0.96 | 0.042 | Pnpla8 NA |
| ccp_change_in_locomotor_activity | 8.7 | 2 | 0 | 0 | -0.89 | 0.110 | Pnpla8 NA |
| crf_mi_active_responses | 5.9 | 2 | 0 | 0 | -0.93 | 0.074 | Pnpla8 NA |
| tautz: manual_mpc18 | 13.4 | 2 | 0 | 0 | 0.47 | 0.530 | Pnpla8 NA |
| tautz: manual_spc12 | 4.8 | 2 | 0 | 0 | 0.00 | 1.000 | Pnpla8 NA |
| tautz: manual_mpc16 | 5.5 | 2 | 0 | 0 | -0.93 | 0.067 | Pnpla8 NA |
| Liver cobalt concentration | 7.1 | 2 | 0 | 0 | 0.53 | 0.472 | Pnpla8 NA |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 0 | 0.000 | 1.6 |
| Adipose | alternative TSS | 0 | 0.000 | 1.5 |
| Adipose | gene expression | 1 | 0.012 | 1.5 |
| Adipose | isoform ratio | 0 | 0.000 | 1.6 |
| Adipose | intron excision ratio | 0 | 0.000 | 1.7 |
| Adipose | mRNA stability | 0 | 0.000 | 1.5 |
| BLA | alternative polyA | 0 | 0.000 | 1.5 |
| BLA | alternative TSS | 0 | 0.000 | 1.7 |
| BLA | gene expression | 1 | 0.016 | 1.6 |
| BLA | isoform ratio | 0 | 0.000 | 1.5 |
| BLA | intron excision ratio | 0 | 0.000 | 1.7 |
| BLA | mRNA stability | 0 | 0.000 | 1.7 |
| Brain | alternative polyA | 0 | 0.000 | 1.5 |
| Brain | alternative TSS | 0 | 0.000 | 1.6 |
| Brain | gene expression | 0 | 0.000 | 1.6 |
| Brain | isoform ratio | 0 | 0.000 | 1.6 |
| Brain | intron excision ratio | 0 | 0.000 | 1.7 |
| Brain | mRNA stability | 0 | 0.000 | 1.6 |
| Eye | alternative polyA | 0 | 0.000 | 1.5 |
| Eye | alternative TSS | 0 | 0.000 | 1.4 |
| Eye | gene expression | 0 | 0.000 | 1.6 |
| Eye | isoform ratio | 0 | 0.000 | 1.7 |
| Eye | intron excision ratio | 0 | 0.000 | 1.7 |
| Eye | mRNA stability | 0 | 0.000 | 1.6 |
| IL | alternative polyA | 0 | 0.000 | 1.6 |
| IL | alternative TSS | 0 | 0.000 | 1.9 |
| IL | gene expression | 0 | 0.000 | 1.6 |
| IL | isoform ratio | 0 | 0.000 | 1.5 |
| IL | intron excision ratio | 0 | 0.000 | 1.6 |
| IL | mRNA stability | 0 | 0.000 | 1.7 |
| LHb | alternative polyA | 0 | 0.000 | 1.6 |
| LHb | alternative TSS | 0 | 0.000 | 1.6 |
| LHb | gene expression | 0 | 0.000 | 1.6 |
| LHb | isoform ratio | 0 | 0.000 | 1.7 |
| LHb | intron excision ratio | 0 | 0.000 | 1.7 |
| LHb | mRNA stability | 0 | 0.000 | 1.7 |
| Liver | alternative polyA | 0 | 0.000 | 1.6 |
| Liver | alternative TSS | 0 | 0.000 | 1.4 |
| Liver | gene expression | 0 | 0.000 | 1.6 |
| Liver | isoform ratio | 0 | 0.000 | 1.5 |
| Liver | intron excision ratio | 0 | 0.000 | 1.5 |
| Liver | mRNA stability | 0 | 0.000 | 1.5 |
| NAcc | alternative polyA | 0 | 0.000 | 1.5 |
| NAcc | alternative TSS | 0 | 0.000 | 1.8 |
| NAcc | gene expression | 0 | 0.000 | 1.6 |
| NAcc | isoform ratio | 0 | 0.000 | 1.5 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.7 |
| NAcc | mRNA stability | 0 | 0.000 | 1.6 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.5 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.8 |
| NAcc2 | gene expression | 0 | 0.000 | 1.6 |
| NAcc2 | isoform ratio | 0 | 0.000 | 1.6 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.6 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.7 |
| OFC | alternative polyA | 0 | 0.000 | 1.4 |
| OFC | alternative TSS | 0 | 0.000 | 1.8 |
| OFC | gene expression | 1 | 0.027 | 1.6 |
| OFC | isoform ratio | 0 | 0.000 | 1.5 |
| OFC | intron excision ratio | 0 | 0.000 | 1.7 |
| OFC | mRNA stability | 0 | 0.000 | 1.6 |
| PL | alternative polyA | 0 | 0.000 | 1.6 |
| PL | alternative TSS | 0 | 0.000 | 1.9 |
| PL | gene expression | 0 | 0.000 | 1.6 |
| PL | isoform ratio | 0 | 0.000 | 1.7 |
| PL | intron excision ratio | 0 | 0.000 | 1.6 |
| PL | mRNA stability | 0 | 0.000 | 1.6 |
| PL2 | alternative polyA | 0 | 0.000 | 1.5 |
| PL2 | alternative TSS | 0 | 0.000 | 1.8 |
| PL2 | gene expression | 1 | 0.016 | 1.6 |
| PL2 | isoform ratio | 0 | 0.000 | 1.6 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.6 |
| PL2 | mRNA stability | 0 | 0.000 | 1.6 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.