Hub : Traits

Locomotor activity

Activity in a novel 24 X 45 cm chamber in the 18-minute session for males and females [n beam breaks/18 min test]

Tags: Behavior · Locomotion

Project: p50_david_dietz

2 loci · 2 genes with independent associations · 16 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr6	60576851	62029190	15	1	7.66e-09	4.47e-08	1.36e-123	Pnpla8
2	chr8	108585012	109845634	1	1	9.96e-22	1.41e-03	1.99e-12	Klhdc8b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	18.84	1	1	50	0	1.00e+00	Klhdc8b
BMI without tail	27.06	1	1	50	0	1.00e+00	Klhdc8b
Body weight	11.67	2	1	50	0	1.00e+00	Klhdc8b Pnpla8
Heart weight	17.24	1	0	0	0	1.00e+00	Klhdc8b
Left kidney weight	27.97	1	1	50	0	1.00e+00	Klhdc8b
Right kidney weight	10.32	1	1	50	0	1.00e+00	Klhdc8b
Tail length	8.12	1	0	0	0	1.00e+00	Klhdc8b
Length with tail	4.94	4	2	100	0.99	1.42e-19	Klhdc8b LOC103692619 LOC120103526 Pnpla8
Length without tail	6.31	3	0	0	1	2.82e-23	LOC103692619 LOC120103526 Pnpla8
Liver weight, left	13.45	1	0	0	0	1.00e+00	Klhdc8b
Retroperitoneal fat weight	6.24	1	0	0	0	1.00e+00	Klhdc8b
Soleus weight	8.84	1	0	0	0	1.00e+00	Klhdc8b
Tibialis anterior weight	3.06	2	0	0	1	9.93e-10	LOC120103526 Pnpla8
Tibia length	10.96	1	1	50	0	1.00e+00	Klhdc8b
Number of licking bursts	24.53	1	1	50	0	1.00e+00	Klhdc8b
Food consumed during 24 hour testing period	9.01	1	0	0	0	1.00e+00	Klhdc8b
Mean num. licks in bursts	11.71	1	0	0	0	1.00e+00	Klhdc8b
Water consumed over 24 hours	8.34	1	0	0	0	1.00e+00	Klhdc8b
Patch foraging indifference point 0 sec	8.18	1	0	0	0	1.00e+00	Klhdc8b
Indifference point function ln k	36.38	1	1	50	0	1.00e+00	Klhdc8b
Indifference point function log k	36.38	1	1	50	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 0 sec	8.89	1	0	0	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 6 sec	6.45	1	0	0	0	1.00e+00	LOC120103526
Patch foraging time to switch 0 sec	7.82	4	0	0	-0.98	2.21e-14	Klhdc8b LOC103692619 LOC120103526 Pnpla8
Locomotor testing distance	18.31	4	4	200	1	1.01e-26	Klhdc8b LOC103692619 LOC120103526 Pnpla8
Locomotor testing rearing	10.16	3	0	0	1	3.15e-28	LOC103692619 LOC120103526 Pnpla8
Light reinforcement 2	7.12	1	0	0	0	1.00e+00	Klhdc8b
Reaction time number correct	18.64	1	1	50	0	1.00e+00	Klhdc8b
Reaction time trials correct on left	18.64	1	1	50	0	1.00e+00	Klhdc8b
Reaction time trials on left	19.51	1	1	50	0	1.00e+00	Klhdc8b
Reaction time mean AUC	9.44	1	0	0	0	1.00e+00	Klhdc8b
Median of all reaction times	10.54	1	0	0	0	1.00e+00	Klhdc8b
Reaction time omissions	23.75	1	1	50	0	1.00e+00	Klhdc8b
Reaction time false alarm rate	20.24	1	1	50	0	1.00e+00	Klhdc8b
Reaction time trials completed	19.51	1	1	50	0	1.00e+00	Klhdc8b
Reaction time trials AUC	20.65	1	1	50	0	1.00e+00	Klhdc8b
Conditioned locomotion	10.55	4	1	50	-1	1.08e-22	Klhdc8b LOC103692619 LOC120103526 Pnpla8
Cocaine response after cond. not corrected	16.6	1	0	0	0	1.00e+00	Klhdc8b
Cocaine response before conditioning	38.66	1	1	50	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	30	1	1	50	0	1.00e+00	Klhdc8b
Pavlov. Cond. intertrial magazine entries	7.56	1	0	0	0	1.00e+00	Klhdc8b
Conditioned reinforcement - inactives	16.77	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 1 inactive lever presses	13.69	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 15 inactive lever presses	30.78	1	1	50	0	1.00e+00	Klhdc8b
Intermittent access day 15 total infusions	14.21	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access terminal intake (last 3 days)	24.03	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access total infusions	15.45	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access day 1 locomotion	11.5	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access standard deviation	16.8	1	0	0	0	1.00e+00	Klhdc8b
Cocaine induced anxiety	13.65	1	0	0	0	1.00e+00	Klhdc8b
Lifetime Intake	9.49	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 2 inactive lever presses	10.83	1	0	0	0	1.00e+00	Klhdc8b
Total sessions with >9 infusions	16	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 total inactive lever presses	13.04	1	0	0	0	1.00e+00	Klhdc8b
Short access day 10 total inactive lever presses	101.65	1	1	50	0	1.00e+00	Klhdc8b
Short access day 10 total infusions	13.17	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 locomotion	11.78	1	0	0	0	1.00e+00	Klhdc8b
One hour access (0.3 mA shock)	13.43	1	0	0	0	1.00e+00	Klhdc8b
One hour access (shock baseline)	8.36	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 1	23.98	1	1	50	0	1.00e+00	Klhdc8b
Locomotion velocity, session 2	10	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 2	33.15	1	1	50	0	1.00e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 3	14.51	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, session 8	9.36	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 8	52.78	1	1	50	0	1.00e+00	Klhdc8b
Degree of sensitization distance	24.75	1	0	0	0	1.00e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	35.59	1	1	50	0	1.00e+00	Klhdc8b
Condit. Reinf. active-inactive response ratio	25.6	1	1	50	0	1.00e+00	Klhdc8b
Condit. Reinf. active responses	18.23	1	0	0	0	1.00e+00	Klhdc8b
Incentive salience index mean	26.23	1	1	50	0	1.00e+00	Klhdc8b
Condit. Reinf. lever presses	10.81	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	50	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 1	13.1	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 1	37.38	1	1	50	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 1	10.76	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, hab. session 1	10.22	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 2	27.1	1	1	50	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 2	10.13	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 2	69.58	1	1	50	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 2	19.2	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, hab. session 2	21.15	1	1	50	0	1.00e+00	Klhdc8b
Novel to familiar place preference ratio	22.33	1	0	0	0	1.00e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1.00e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, NPP test	106.24	1	1	50	0	1.00e+00	Klhdc8b
Total locomotion distance, NPP test	47.64	1	1	50	0	1.00e+00	Klhdc8b
Locomotion velocity, NPP test	51.12	1	1	50	0	1.00e+00	Klhdc8b
Pavlov. Cond. change in total contacts	69.48	1	1	50	0	1.00e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. latency score	8.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	12.23	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. response bias	10.49	1	0	0	0	1.00e+00	Klhdc8b
Bone: maximum force	7.19	1	0	0	0	1.00e+00	Klhdc8b
Bone: stiffness	13.41	1	0	0	0	1.00e+00	Klhdc8b
Delta time in closed arm before/after self-admin	12.84	1	0	0	0	1.00e+00	Klhdc8b
Time to tail flick, vehicle, after self-admin	37.57	1	1	50	0	1.00e+00	Klhdc8b
Delta time to tail flick, vehicle, before/after SA	14.47	1	0	0	0	1.00e+00	Klhdc8b
Total heroin consumption	18.89	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 0s delay	28.7	1	1	50	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 16s delay	13.12	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 4s delay	41.82	1	1	50	0	1.00e+00	Klhdc8b
Fecal boli incidents, locomotor time 1	16.98	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 1	22.55	1	0	0	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 1	31.01	1	1	50	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 1	49.01	1	1	50	0	1.00e+00	Klhdc8b
Bouts of movement, locomotor time 2	19.85	1	0	0	0	1.00e+00	Klhdc8b
Total resting periods, locomotor time 2	20.22	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 2	25.34	1	1	50	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 2	42.39	1	1	50	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 2	54.92	1	1	50	0	1.00e+00	Klhdc8b
Weight adjusted by age	30.32	1	1	50	0	1.00e+00	Klhdc8b
Food seeking constrained by brief footshock	12.71	1	0	0	0	1.00e+00	Klhdc8b
Cd content in liver	20.17	1	0	0	0	1.00e+00	Klhdc8b
Co content in liver	8.13	2	0	0	1	1.88e-11	LOC103692619 LOC120103526
Fe content in liver	40.39	1	1	50	0	1.00e+00	Klhdc8b
K content in liver	12.22	1	0	0	0	1.00e+00	Klhdc8b
Mg content in liver	15.79	1	0	0	0	1.00e+00	Klhdc8b
Na content in liver	16.36	1	0	0	0	1.00e+00	Klhdc8b
Rb content in liver	51.88	1	1	50	0	1.00e+00	Klhdc8b
Se content in liver	8.45	1	0	0	0	1.00e+00	Klhdc8b
Sr content in liver	22.41	1	0	0	0	1.00e+00	Klhdc8b
Zn content in liver	9.95	1	0	0	0	1.00e+00	Klhdc8b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	4	0.1	1.62
Adipose	alternative TSS	0	0	1.46
Adipose	gene expression	1	0	1.55
Adipose	isoform ratio	3	0.1	1.56
Adipose	intron excision ratio	0	0	1.63
Adipose	mRNA stability	0	0	1.55
BLA	alternative polyA	0	0	1.49
BLA	alternative TSS	0	0	1.69
BLA	gene expression	0	0	1.64
BLA	isoform ratio	0	0	1.61
BLA	intron excision ratio	0	0	1.73
BLA	mRNA stability	0	0	1.65
Brain	alternative polyA	0	0	1.57
Brain	alternative TSS	0	0	1.63
Brain	gene expression	0	0	1.57
Brain	isoform ratio	0	0	1.54
Brain	intron excision ratio	0	0	1.65
Brain	mRNA stability	0	0	1.56
Eye	alternative polyA	0	0	1.43
Eye	alternative TSS	0	0	1.87
Eye	gene expression	0	0	1.56
Eye	isoform ratio	0	0	1.61
Eye	intron excision ratio	0	0	1.66
Eye	mRNA stability	0	0	1.52
IL	alternative polyA	0	0	1.49
IL	alternative TSS	0	0	1.59
IL	gene expression	0	0	1.62
IL	isoform ratio	0	0	1.59
IL	intron excision ratio	0	0	1.61
IL	mRNA stability	0	0	1.7
LHb	alternative polyA	0	0	1.52
LHb	alternative TSS	0	0	1.87
LHb	gene expression	0	0	1.61
LHb	isoform ratio	0	0	1.66
LHb	intron excision ratio	0	0	1.67
LHb	mRNA stability	0	0	1.64
Liver	alternative polyA	0	0	1.61
Liver	alternative TSS	0	0	1.53
Liver	gene expression	1	0	1.56
Liver	isoform ratio	0	0	1.5
Liver	intron excision ratio	0	0	1.49
Liver	mRNA stability	0	0	1.51
NAcc	alternative polyA	0	0	1.51
NAcc	alternative TSS	2	0.1	1.71
NAcc	gene expression	2	0	1.62
NAcc	isoform ratio	0	0	1.62
NAcc	intron excision ratio	0	0	1.53
NAcc	mRNA stability	0	0	1.61
OFC	alternative polyA	0	0	1.42
OFC	alternative TSS	0	0	1.77
OFC	gene expression	0	0	1.64
OFC	isoform ratio	0	0	1.58
OFC	intron excision ratio	0	0	1.67
OFC	mRNA stability	0	0	1.61
PL	alternative polyA	4	0.1	1.52
PL	alternative TSS	0	0	1.64
PL	gene expression	2	0	1.62
PL	isoform ratio	0	0	1.59
PL	intron excision ratio	0	0	1.59
PL	mRNA stability	0	0	1.62
pVTA	alternative polyA	2	0.1	1.49
pVTA	alternative TSS	0	0	1.78
pVTA	gene expression	0	0	1.6
pVTA	isoform ratio	0	0	1.6
pVTA	intron excision ratio	0	0	1.61
pVTA	mRNA stability	0	0	1.68
RMTg	alternative polyA	0	0	1.46
RMTg	alternative TSS	0	0	1.68
RMTg	gene expression	0	0	1.65
RMTg	isoform ratio	0	0	1.52
RMTg	intron excision ratio	0	0	1.61
RMTg	mRNA stability	0	0	1.52