Hub : Traits

Locomotor activity

Activity in a novel 24 X 45 cm chamber in the 18-minute session for males and females [n beam breaks/18 min test]

Tags: Behavior · Locomotion

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr5	73743882	75140400	1	1	3.66e-08	8.14e-06	3.11e-01	LOC120103152
2	chr6	66300909	67827466	3	1	9.03e-08	9.03e-08	3.18e-02	Nrcam
3	chr8	117463629	118343328	1	1	9.91e-11	1.95e-02	1.00e+00	Mst1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	9.27	1	1	33.3	0	1.00e+00	Mst1
Epididymis fat weight	23.69	1	1	33.3	0	1.00e+00	Mst1
Glucose	130.26	1	1	33.3	0	1.00e+00	Mst1
Right kidney weight	17.32	1	1	33.3	0	1.00e+00	Mst1
Tail length	2.03	1	0	0	0	1.00e+00	Mst1
Length with tail	3.89	4	1	33.3	0.33	5.29e-01	Dnajb9 LOC120103526 Mst1 Nrcam
Length without tail	13.73	1	1	33.3	0	1.00e+00	Mst1
Liver weight, left	23.79	1	1	33.3	0	1.00e+00	Mst1
Liver weight, right	41.45	1	1	33.3	0	1.00e+00	Mst1
Retroperitoneal fat weight	32.58	1	1	33.3	0	1.00e+00	Mst1
Extensor digitorum longus weight	4.43	1	0	0	0	1.00e+00	Mst1
Soleus weight	2.51	1	0	0	0	1.00e+00	Mst1
Tibialis anterior weight	2.86	4	0	0	0.59	2.16e-01	Dnajb9 LOC120103526 Mst1 Nrcam
Tibia length	25.39	1	1	33.3	0	1.00e+00	Mst1
Food consumed during 24 hour testing period	12.71	1	0	0	0	1.00e+00	Mst1
Times rat made contact with spout	6.79	2	0	0	0.24	7.57e-01	Dnajb9 LOC120103526
Std. dev. time between licks in bursts	12.2	1	0	0	0	1.00e+00	Mst1
Water consumed over 24 hours	7	1	0	0	0	1.00e+00	Mst1
Patch foraging indifference point 0 sec	10.65	1	0	0	0	1.00e+00	Mst1
Patch foraging indifference point AUC	100.95	1	1	33.3	0	1.00e+00	Mst1
Indifference point function ln k	165.9	1	1	33.3	0	1.00e+00	Mst1
Indifference point function log k	165.9	1	1	33.3	0	1.00e+00	Mst1
Patch foraging total patch changes 0 sec	7.71	1	0	0	0	1.00e+00	Mst1
Patch foraging total patch changes 12 sec	62.77	1	1	33.3	0	1.00e+00	Mst1
Patch foraging total patch changes 18 sec	19.07	1	1	33.3	0	1.00e+00	Mst1
Patch foraging total patch changes 24 sec	48.07	1	1	33.3	0	1.00e+00	Mst1
Patch foraging total patch changes 6 sec	4.88	3	0	0	0	1.00e+00	Dnajb9 LOC120103526 Nrcam
Patch foraging time to switch 0 sec	6.45	4	0	0	-0.99	1.82e-04	Dnajb9 LOC120103526 Mst1 Nrcam
Patch foraging water rate 12 sec	4.41	3	0	0	0	1.00e+00	LOC120103526 Mst1 Nrcam
Patch foraging water rate 18 sec	5.97	1	0	0	0	1.00e+00	Mst1
Patch foraging water rate 24 sec	14.38	1	0	0	0	1.00e+00	Mst1
Locomotor testing distance	15.78	5	1	33.3	1	9.38e-07	Dnajb9 LOC120103152 LOC120103526 Mst1 Nrcam
Locomotor testing rearing	11.99	5	1	33.3	0.97	2.28e-04	Dnajb9 LOC120103152 LOC120103526 Mst1 Nrcam
Light reinforcement 1	3.12	1	0	0	0	1.00e+00	Mst1
Light reinforcement 2	57.81	1	1	33.3	0	1.00e+00	Mst1
Reaction time mean minus median	3.66	1	0	0	0	1.00e+00	Mst1
Reaction time mean minus median AUC	19.53	1	1	33.3	0	1.00e+00	Mst1
Reaction time num false alarms	14.38	1	0	0	0	1.00e+00	Mst1
Reaction time num false alarms AUC	10.77	1	0	0	0	1.00e+00	Mst1
Reaction time mean AUC	5.59	1	0	0	0	1.00e+00	LOC120103152
Reaction time omissions	5.09	1	0	0	0	1.00e+00	Mst1
Reaction time false alarm rate	12.8	1	0	0	0	1.00e+00	Mst1
Std. dev. reaction times	10.43	1	0	0	0	1.00e+00	Mst1
Social response proportion	18.87	1	0	0	0	1.00e+00	Mst1
Social responses	15.18	1	0	0	0	1.00e+00	Mst1
Social time	6.56	1	0	0	0	1.00e+00	Mst1
Conditioned locomotion	13.42	3	0	0	-1	1.50e-06	Dnajb9 LOC120103526 Nrcam
Saline control response	117.68	1	1	33.3	0	1.00e+00	Mst1
Condit. Reinf. active minus inactive responses	21.07	1	1	33.3	0	1.00e+00	Mst1
Condit. Reinf. active responses	28.32	1	1	33.3	0	1.00e+00	Mst1
Condit. Reinf. inactive responses	43.12	1	1	33.3	0	1.00e+00	Mst1
Condit. Reinf. lever presses	62.89	1	1	33.3	0	1.00e+00	Mst1
Condit. Reinf. lever reinforcers received	18.27	1	0	0	0	1.00e+00	Mst1
Pavlov. Cond. lever latency	24.86	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. magazine entry latency	194.32	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. index score	70.13	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. latency score	67.67	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. lever contacts	48.37	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. magazine entry number	182.99	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. intertrial magazine entries	127.35	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. lever-magazine prob. diff.	76.24	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. response bias	117.68	1	1	33.3	0	1.00e+00	Mst1
Conditioned reinforcement - inactives	143.92	1	1	33.3	0	1.00e+00	Mst1
Conditioned locomotion	11.68	1	0	0	0	1.00e+00	Mst1
Intermittent access intake day 1-15 change	15.73	1	1	33.3	0	1.00e+00	Mst1
Intermittent access intake escalation	13.65	1	1	33.3	0	1.00e+00	Mst1
Intermittent access intake escalation 2	8.15	1	0	0	0	1.00e+00	Mst1
Intermitt. access day 1 inactive lever presses	72.45	1	1	33.3	0	1.00e+00	Mst1
Intermitt. access escalation Index	104.94	1	1	33.3	0	1.00e+00	Mst1
Intermittent access day 1 total infusions	10.24	1	0	0	0	1.00e+00	Mst1
Intermittent access total locomotion	9.63	1	0	0	0	1.00e+00	Mst1
Intermittent access standard deviation	28.26	1	1	33.3	0	1.00e+00	Mst1
Post-drug Anxiety	7.32	1	0	0	0	1.00e+00	Mst1
Progressive ratio test 1 inactive lever presses	35.26	1	1	33.3	0	1.00e+00	Mst1
Progressive ratio test 2 inactive lever presses	5.51	1	0	0	0	1.00e+00	Mst1
Total sessions with >9 infusions	52	1	1	33.3	0	1.00e+00	Mst1
Short access day 1 total inactive lever presses	92.29	1	1	33.3	0	1.00e+00	Mst1
Short access day 10 total inactive lever presses	64.64	1	1	33.3	0	1.00e+00	Mst1
Short access day 1 total infusions	10.81	1	0	0	0	1.00e+00	Mst1
Short access day 10 total infusions	36.76	1	1	33.3	0	1.00e+00	Mst1
Short access day 1 locomotion	7.56	2	0	0	0	1.00e+00	LOC120103152 Mst1
Short access day 10 total locomotion	11.97	1	0	0	0	1.00e+00	Mst1
Short access total locomotion	33.51	1	1	33.3	0	1.00e+00	Mst1
Compulsive drug intake	11.99	1	0	0	0	1.00e+00	Mst1
Number of responses in last shaping day	7.47	1	0	0	0	1.00e+00	Mst1
Locomotion velocity, session 2	62.64	1	1	33.3	0	1.00e+00	Mst1
Locomotion distance, session 2	8.11	1	0	0	0	1.00e+00	Mst1
Stereotopy head waving bouts, day 3	21.87	1	0	0	0	1.00e+00	Mst1
Stereotopy head waving duration, day 3	19.72	1	0	0	0	1.00e+00	Mst1
Locomotion velocity, session 7	128.48	1	1	33.3	0	1.00e+00	Mst1
Locomotion distance, session 7	157.43	1	1	33.3	0	1.00e+00	Mst1
Degree of sensitization distance	108.37	1	1	33.3	0	1.00e+00	Mst1
Degree of sensitization stereotypy	12.02	1	0	0	0	1.00e+00	Mst1
Condit. Reinf. active responses	6.46	1	0	0	0	1.00e+00	Nrcam
Condit. Reinf. inactive responses	14.54	1	0	0	0	1.00e+00	Mst1
Incentive salience index mean	13.57	2	0	0	0	1.00e+00	Mst1 Nrcam
Condit. Reinf. lever presses	51.29	1	1	33.3	0	1.00e+00	Mst1
Time in familiar zone, hab. session 1	17.96	1	0	0	0	1.00e+00	Mst1
Time in novel zone, hab. session 1	27.1	1	1	33.3	0	1.00e+00	Mst1
Time in familiar zone, hab. session 2	52.29	1	1	33.3	0	1.00e+00	Mst1
Time in novel zone, hab. session 2	105.16	1	1	33.3	0	1.00e+00	Mst1
Total zone transitions, hab. session 2	13.14	1	0	0	0	1.00e+00	Mst1
Total locomotion distance, hab. session 2	6.29	1	0	0	0	1.00e+00	Mst1
Novel to familiar place preference ratio	17.62	1	0	0	0	1.00e+00	Mst1
Novelty place preference	21.83	1	0	0	0	1.00e+00	Mst1
Time in novel zone, NPP test	15.06	1	0	0	0	1.00e+00	Mst1
Pavlov. Cond. lever latency	62.17	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. change in total contacts	7.89	1	0	0	0	1.00e+00	Mst1
Pavlov. Cond. index score	43.71	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. latency score	44.27	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. lever contacts	68.82	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. magazine entry number	10.28	1	0	0	0	1.00e+00	Mst1
Pavlov. Cond. intertrial magazine entries	41.87	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. lever-magazine prob. diff.	28.64	1	1	33.3	0	1.00e+00	Mst1
Pavlov. Cond. response bias	22.58	1	1	33.3	0	1.00e+00	Mst1
Bone surface	20.92	1	1	33.3	0	1.00e+00	Mst1
Bone volume	10.01	1	0	0	0	1.00e+00	Mst1
Bone: connectivity density	8.52	1	0	0	0	1.00e+00	Mst1
Bone: cortical area	89.8	1	1	33.3	0	1.00e+00	Mst1
Bone: cortical porosity	7.46	1	0	0	0	1.00e+00	Mst1
Bone: cortical thickness	90.46	1	1	33.3	0	1.00e+00	Mst1
Bone: cortical thickness	58.31	1	1	33.3	0	1.00e+00	Mst1
Bone: elastic work	29.76	1	1	33.3	0	1.00e+00	Mst1
Bone: endosteal estimation	5.8	1	0	0	0	1.00e+00	Mst1
Bone: endosteal perimeter	9.06	1	0	0	0	1.00e+00	Mst1
Bone: final force	80	1	1	33.3	0	1.00e+00	Mst1
Bone: final moment	74.6	1	1	33.3	0	1.00e+00	Mst1
Bone: marrow area	7.82	1	0	0	0	1.00e+00	Mst1
Bone: maximum diameter	35.45	2	1	33.3	0	1.00e+00	Mst1 Nrcam
Bone: maximum force	83.55	1	1	33.3	0	1.00e+00	Mst1
Bone: maximum moment	79.89	1	1	33.3	0	1.00e+00	Mst1
Bone: minimum diameter	21.89	1	1	33.3	0	1.00e+00	Mst1
Bone: periosteal estimation	47.47	1	1	33.3	0	1.00e+00	Mst1
Bone: periosteal perimeter	45.62	1	1	33.3	0	1.00e+00	Mst1
Bone: post-yield work	13.28	1	0	0	0	1.00e+00	Mst1
Bone: stiffness	75.59	1	1	33.3	0	1.00e+00	Mst1
Bone: trabecular spacing	31.4	1	1	33.3	0	1.00e+00	Mst1
Bone: trabecular thickness	38.53	1	1	33.3	0	1.00e+00	Mst1
Bone: trabecular tissue density	23.06	1	1	33.3	0	1.00e+00	Mst1
Breakpoint value in progressive ratio session	13.35	1	0	0	0	1.00e+00	Mst1
Delta time in closed arm before/after self-admin	8.72	1	0	0	0	1.00e+00	Mst1
Delta time in open arm before/after self-admin	8.85	1	0	0	0	1.00e+00	Mst1
Diff in mean of infusions in LGA sessions	23.6	1	1	33.3	0	1.00e+00	Mst1
Extinction: sum of active levers before priming	69.64	1	1	33.3	0	1.00e+00	Mst1
Active lever presses in extinction session 6	30.5	1	1	33.3	0	1.00e+00	Mst1
Time in closed arm before self-admin	48.75	1	1	33.3	0	1.00e+00	Mst1
Time in closed arm after self-admin	61.4	1	1	33.3	0	1.00e+00	Mst1
Time in open arm before self-admin	12.71	1	0	0	0	1.00e+00	Mst1
Time in open arm after self-admin	77.83	1	1	33.3	0	1.00e+00	Mst1
Time to tail flick, vehicle, before self-admin	28.77	1	1	33.3	0	1.00e+00	Mst1
Time to tail flick, test, before self-admin	7.29	1	0	0	0	1.00e+00	Mst1
Delta time to tail flick, vehicle, before/after SA	42.22	1	1	33.3	0	1.00e+00	Mst1
Delta time to tail flick, test, before/after SA	11.02	1	0	0	0	1.00e+00	Mst1
Ambulatory time after self-admin	7.86	1	0	0	0	1.00e+00	Mst1
Delay disc. indifference point, 4s delay	7.27	1	0	0	0	1.00e+00	Mst1
Run reversals in cocaine runway, females	8.06	3	0	0	-1	8.19e-07	Dnajb9 LOC120103526 Nrcam
Co content in liver	6.24	1	0	0	0	1.00e+00	Dnajb9

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.52
Adipose	alternative TSS	0	0	1.53
Adipose	gene expression	2	0	1.56
Adipose	isoform ratio	0	0	1.51
Adipose	intron excision ratio	0	0	1.61
Adipose	mRNA stability	0	0	1.54
BLA	alternative polyA	0	0	1.52
BLA	alternative TSS	0	0	1.7
BLA	gene expression	0	0	1.62
BLA	isoform ratio	0	0	1.62
BLA	intron excision ratio	0	0	1.75
BLA	mRNA stability	0	0	1.58
Brain	alternative polyA	0	0	1.53
Brain	alternative TSS	0	0	1.51
Brain	gene expression	0	0	1.55
Brain	isoform ratio	0	0	1.53
Brain	intron excision ratio	0	0	1.69
Brain	mRNA stability	0	0	1.56
Eye	alternative polyA	0	0	1.63
Eye	alternative TSS	0	0	1.75
Eye	gene expression	0	0	1.6
Eye	isoform ratio	0	0	1.65
Eye	intron excision ratio	0	0	1.64
Eye	mRNA stability	0	0	1.53
IC	alternative polyA	0	0	1.47
IC	alternative TSS	0	0	1.62
IC	gene expression	0	0	1.61
IC	isoform ratio	0	0	1.5
IC	intron excision ratio	0	0	1.68
IC	mRNA stability	0	0	1.63
IL	alternative polyA	0	0	1.5
IL	alternative TSS	0	0	1.56
IL	gene expression	0	0	1.62
IL	isoform ratio	0	0	1.68
IL	intron excision ratio	0	0	1.67
IL	mRNA stability	0	0	1.63
LHb	alternative polyA	0	0	1.51
LHb	alternative TSS	0	0	1.72
LHb	gene expression	0	0	1.58
LHb	isoform ratio	0	0	1.68
LHb	intron excision ratio	0	0	1.65
LHb	mRNA stability	0	0	1.58
Liver	alternative polyA	0	0	1.54
Liver	alternative TSS	0	0	1.41
Liver	gene expression	1	0	1.55
Liver	isoform ratio	1	0	1.49
Liver	intron excision ratio	0	0	1.48
Liver	mRNA stability	0	0	1.5
NAcc	alternative polyA	0	0	1.53
NAcc	alternative TSS	0	0	1.62
NAcc	gene expression	0	0	1.59
NAcc	isoform ratio	0	0	1.58
NAcc	intron excision ratio	0	0	1.62
NAcc	mRNA stability	0	0	1.59
OFC	alternative polyA	0	0	1.45
OFC	alternative TSS	0	0	1.61
OFC	gene expression	0	0	1.62
OFC	isoform ratio	0	0	1.54
OFC	intron excision ratio	1	0.1	1.76
OFC	mRNA stability	0	0	1.56
PL	alternative polyA	0	0	1.57
PL	alternative TSS	0	0	1.59
PL	gene expression	1	0	1.59
PL	isoform ratio	0	0	1.55
PL	intron excision ratio	0	0	1.62
PL	mRNA stability	0	0	1.61
pVTA	alternative polyA	0	0	1.52
pVTA	alternative TSS	0	0	1.64
pVTA	gene expression	1	0	1.58
pVTA	isoform ratio	0	0	1.52
pVTA	intron excision ratio	0	0	1.68
pVTA	mRNA stability	0	0	1.6
RMTg	alternative polyA	0	0	1.59
RMTg	alternative TSS	0	0	1.65
RMTg	gene expression	0	0	1.67
RMTg	isoform ratio	0	0	1.67
RMTg	intron excision ratio	0	0	1.53
RMTg	mRNA stability	0	0	1.62