Progressive ratio test 2 active lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr1 166093700 167491708 1 1 4.36e-12 3.08e-04 1.08e-08 Tead1
2 chr9 75969545 77365260 1 1 2.12e-27 3.33e-01 1.00e+00 Zfand2b
3 chr19 32676171 34074113 1 1 9.08e-08 3.39e-02 1.82e-01 Zdhhc1

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 5.39 2 1 33.3 0 1e+00 Tead1 Zfand2b
BMI without tail 53.65 1 1 33.3 0 1e+00 Zfand2b
Epididymis fat weight 57.61 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Heart weight 71.7 1 1 33.3 0 1e+00 Zfand2b
Left kidney weight 19.82 2 2 66.7 0 1e+00 Zdhhc1 Zfand2b
Right kidney weight 33.45 2 2 66.7 0 1e+00 Zdhhc1 Zfand2b
Tail length 125.62 1 1 33.3 0 1e+00 Zfand2b
Length with tail 4.78 1 0 0 0 1e+00 Zfand2b
Length without tail 77.43 1 1 33.3 0 1e+00 Zfand2b
Liver weight, right 17.57 1 1 33.3 0 1e+00 Zfand2b
Parametrial fat weight 9.74 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Retroperitoneal fat weight 5.11 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Intraocular pressure 28.08 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Number of licking bursts 32.5 1 1 33.3 0 1e+00 Zfand2b
Food consumed during 24 hour testing period 15.78 1 0 0 0 1e+00 Zfand2b
Times rat made contact with spout 9.25 1 0 0 0 1e+00 Zfand2b
Mean time between licks in bursts 9.22 1 0 0 0 1e+00 Zfand2b
Mean num. licks in bursts 18.13 1 0 0 0 1e+00 Zfand2b
Std. dev. time between licks in bursts 12.12 1 0 0 0 1e+00 Zfand2b
Water consumed over 24 hours 34.33 1 1 33.3 0 1e+00 Zfand2b
Patch foraging indifference point 0 sec 11.19 2 0 0 0 1e+00 Tead1 Zfand2b
Patch foraging indifference point AUC 16.01 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Indifference point function ln k 54.42 1 1 33.3 0 1e+00 Zfand2b
Indifference point function log k 54.42 1 1 33.3 0 1e+00 Zfand2b
Patch foraging total patch changes 0 sec 16.31 2 1 33.3 0 1e+00 Tead1 Zfand2b
Patch foraging total patch changes 12 sec 9.53 1 0 0 0 1e+00 Tead1
Patch foraging total patch changes 18 sec 48.28 1 1 33.3 0 1e+00 Zfand2b
Patch foraging total patch changes 24 sec 42.21 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Patch foraging total patch changes 6 sec 11.87 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Patch foraging time to switch 0 sec 19.75 2 1 33.3 0 1e+00 Tead1 Zfand2b
Patch foraging water rate 0 sec 39.47 1 1 33.3 0 1e+00 Zfand2b
Patch foraging water rate 12 sec 69.49 1 1 33.3 0 1e+00 Zfand2b
Patch foraging water rate 18 sec 7.84 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Patch foraging water rate 24 sec 10.78 2 0 0 0 1e+00 Tead1 Zfand2b
Patch foraging water rate 6 sec 20.78 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Locomotor activity 10.45 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Locomotor testing distance 47.2 1 1 33.3 0 1e+00 Zfand2b
Locomotor testing rearing 52.87 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Light reinforcement 1 14.51 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Light reinforcement 2 5.74 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Reaction time number correct 60.58 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time mean minus median 179.03 1 1 33.3 0 1e+00 Zfand2b
Reaction time mean minus median AUC 119.61 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time num false alarms 5.7 1 0 0 0 1e+00 Zfand2b
Reaction time num false alarms AUC 27.43 1 1 33.3 0 1e+00 Zfand2b
Reaction time trials correct on left 60.58 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time trials on left 56.77 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time mean 21.51 3 2 66.7 0 1e+00 Tead1 Zdhhc1 Zfand2b
Reaction time mean AUC 26.7 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Median of all reaction times 16.16 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Reaction time omissions 46.56 1 1 33.3 0 1e+00 Zfand2b
Reaction time premature initiations 41.6 1 1 33.3 0 1e+00 Zfand2b
Std. dev. reaction times 40.77 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time trials completed 56.77 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Reaction time trials AUC 57.6 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Social response proportion 8.47 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Conditioned locomotion 5.5 1 0 0 0 1e+00 Zdhhc1
Cocaine response after cond. corrected 12.71 1 0 0 0 1e+00 Zfand2b
Cocaine response after cond. not corrected 10.73 1 0 0 0 1e+00 Zfand2b
Saline control response 8.43 1 0 0 0 1e+00 Zfand2b
Condit. Reinf. lever presses 5.55 1 0 0 0 1e+00 Zfand2b
Conditioned reinforcement - actives 152.54 1 1 33.3 0 1e+00 Zfand2b
Conditioned reinforcement - inactives 72.86 2 1 33.3 0 1e+00 Tead1 Zfand2b
Conditioned locomotion 10.02 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Intermittent access intake day 1-15 change 81.91 2 1 33.3 0 1e+00 Tead1 Zfand2b
Intermittent access intake escalation 117.41 1 1 33.3 0 1e+00 Zfand2b
Intermittent access intake escalation 2 7.7 1 0 0 0 1e+00 Tead1
Intermitt. access day 1 inactive lever presses 89.31 2 1 33.3 0 1e+00 Tead1 Zfand2b
Intermitt. access day 15 inactive lever presses 104.4 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Intermittent access day 1 total infusions 45.93 3 2 66.7 0 1e+00 Tead1 Zdhhc1 Zfand2b
Intermittent access day 15 total infusions 19.3 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Intermittent access terminal intake (last 3 days) 16.73 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Intermittent access total infusions 29.48 2 1 33.3 0 1e+00 Tead1 Zdhhc1
Intermittent access day 1 locomotion 18.95 2 1 33.3 0 1e+00 Tead1 Zfand2b
Intermittent access day 15 total locomotion 93.08 1 1 33.3 0 1e+00 Zfand2b
Intermittent access total locomotion 9.82 2 0 0 0 1e+00 Tead1 Zfand2b
Intermittent access standard deviation 229.11 2 1 33.3 0 1e+00 Tead1 Zfand2b
Cocaine induced anxiety 125.35 1 1 33.3 0 1e+00 Zfand2b
Post-drug Anxiety 8.64 1 0 0 0 1e+00 Zdhhc1
Baseline Anxiety 393.92 1 1 33.3 0 1e+00 Zfand2b
Lifetime Intake 28.54 2 1 33.3 0 1e+00 Tead1 Zdhhc1
Incentive Sensitization - Responses 125.24 3 3 100 0 1e+00 Tead1 Zdhhc1 Zfand2b
Incentive Sensitization - Breakpoint 121.83 3 3 100 0 1e+00 Tead1 Zdhhc1 Zfand2b
Progressive ratio test 1 active lever presses 21.26 3 2 66.7 0 1e+00 Tead1 Zdhhc1 Zfand2b
Progressive ratio test 1 breakpoint 21.61 2 0 0 0 1e+00 Tead1 Zfand2b
Progressive ratio test 1 inactive lever presses 5.93 2 0 0 0 1e+00 Tead1 Zdhhc1
Progressive ratio test 2 breakpoint 57.23 3 2 66.7 0 1e+00 Tead1 Zdhhc1 Zfand2b
Progressive ratio test 2 inactive lever presses 35.12 2 1 33.3 0 1e+00 Tead1 Zfand2b
Total sessions with >9 infusions 35.75 2 1 33.3 0 1e+00 Tead1 Zdhhc1
Short access day 1 total inactive lever presses 21.93 1 0 0 0 1e+00 Zfand2b
Short access day 10 total inactive lever presses 21.49 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Short access day 1 total infusions 15.66 2 0 0 0 1e+00 Tead1 Zdhhc1
Short access day 10 total infusions 55.42 2 1 33.3 0 1e+00 Tead1 Zdhhc1
Short access total infusions 31.58 2 1 33.3 0 1e+00 Tead1 Zdhhc1
Short access day 1 locomotion 69.81 2 1 33.3 0 1e+00 Tead1 Zfand2b
Short access day 10 total locomotion 432.47 1 1 33.3 0 1e+00 Zfand2b
Short access total locomotion 118.79 2 2 66.7 0 1e+00 Tead1 Zfand2b
Compulsive drug intake 45.32 2 1 33.3 0 1e+00 Tead1 Zfand2b
One hour access (0.3 mA shock) 22.58 1 0 0 0 1e+00 Zfand2b
One hour access (shock baseline) 14.65 1 0 0 0 1e+00 Zdhhc1
Number of responses in last shaping day 32.11 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Locomotion distance, session 2 4.45 1 0 0 0 1e+00 Zfand2b
Bone surface 3.9 1 0 0 0 1e+00 Zdhhc1
Bone volume 4.11 1 0 0 0 1e+00 Zdhhc1
Bone: cortical porosity 5.3 1 0 0 0 1e+00 Tead1
Bone: cortical porosity 7.17 1 0 0 0 1e+00 Tead1
Bone: elastic displacement 5.56 1 0 0 0 1e+00 Zfand2b
Breakpoint value in progressive ratio session 11.08 1 0 0 0 1e+00 Tead1
Distance traveled before self-admin 21.36 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Distance traveled after self-admin 10.31 2 0 0 0 1e+00 Tead1 Zfand2b
Delta time in open arm before/after self-admin 19.84 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Extinction: sum of active levers before priming 6.15 1 0 0 0 1e+00 Zdhhc1
Active lever presses in extinction session 6 18.22 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Delta ambulatory time before/after self-admin 11.38 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Time in closed arm before self-admin 22.87 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Time in closed arm after self-admin 7.8 2 0 0 0 1e+00 Tead1 Zdhhc1
Time in open arm before self-admin 24.67 1 0 0 0 1e+00 Zfand2b
Sum of active levers in priming session hrs 5-6 6.97 1 0 0 0 1e+00 Zfand2b
Time to tail flick, vehicle, before self-admin 18.85 1 0 0 0 1e+00 Zdhhc1
Time to tail flick, vehicle, after self-admin 75.62 1 1 33.3 0 1e+00 Zfand2b
Time to tail flick, test, before self-admin 10.68 1 0 0 0 1e+00 Zfand2b
Time to tail flick, test, after self-admin 5.63 1 0 0 0 1e+00 Zfand2b
Delta time to tail flick, vehicle, before/after SA 40.25 2 1 33.3 0 1e+00 Tead1 Zfand2b
Ambulatory time before self-admin 22.98 3 1 33.3 0 1e+00 Tead1 Zdhhc1 Zfand2b
Ambulatory time after self-admin 19.2 1 0 0 0 1e+00 Tead1
Total heroin consumption 6.81 1 0 0 0 1e+00 Tead1
Area under the delay curve 31.15 1 1 33.3 0 1e+00 Zfand2b
Delay disc. indifference point, 0s delay 5.71 1 0 0 0 1e+00 Zfand2b
Delay disc. indifference point, 16s delay 69.03 1 1 33.3 0 1e+00 Zfand2b
Delay disc. indifference point, 2s delay 7.52 1 0 0 0 1e+00 Zdhhc1
Delay disc. indifference point, 24s delay 27.43 1 0 0 0 1e+00 Zfand2b
Delay disc. indifference point, 8s delay 74.24 1 1 33.3 0 1e+00 Zfand2b
Delay discount exponential model param 16.14 1 0 0 0 1e+00 Zfand2b
Delay discount hyperbolic model param 15.89 1 0 0 0 1e+00 Zfand2b
Fecal boli incidents, locomotor time 1 176.47 1 1 33.3 0 1e+00 Zfand2b
Time >=10cm from walls, locomotor time 1 47.52 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Bouts of movement, locomotor time 1 6.19 1 0 0 0 1e+00 Zfand2b
Rest time, locomotor task time 1 8.65 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Distance moved, locomotor task time 1 5.4 1 0 0 0 1e+00 Zdhhc1
Vertical activity count, locomotor time 1 97.7 1 1 33.3 0 1e+00 Zfand2b
Time >=10cm from walls, locomotor time 2 5.83 1 0 0 0 1e+00 Zdhhc1
Bouts of movement, locomotor time 2 23.9 1 0 0 0 1e+00 Zfand2b
Total resting periods, locomotor time 2 36.28 1 1 33.3 0 1e+00 Zfand2b
Rest time, locomotor task time 2 30.26 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Distance moved, locomotor task time 2 50.91 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Vertical activity count, locomotor time 2 12.25 2 0 0 0 1e+00 Zdhhc1 Zfand2b
Weight adjusted by age 9.91 1 0 0 0 1e+00 Zfand2b
Seeking ratio, delayed vs. immediate footshock 6.97 2 0 0 0 1e+00 Tead1 Zfand2b
Locomotion in novel chamber post-restriction 14.04 1 0 0 0 1e+00 Zfand2b
Progressive ratio 22.47 1 0 0 0 1e+00 Zdhhc1
Food seeking constrained by brief footshock 14.98 1 0 0 0 1e+00 Zfand2b
Seeking ratio, punishment vs. effort 9.83 1 0 0 0 1e+00 Zdhhc1
Run reversals in cocaine runway, females 36.45 1 1 33.3 0 1e+00 Zfand2b
Latency to leave start box in cocaine runway 34.23 1 1 33.3 0 1e+00 Zfand2b
Latency to leave start box in cocaine runway, F 20.83 2 1 33.3 0 1e+00 Zdhhc1 Zfand2b
Latency to leave start box in cocaine runway, M 42.07 1 1 33.3 0 1e+00 Zdhhc1

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.01
Adipose alternative TSS 0 0 0.97
Adipose gene expression 0 0 1.06
Adipose isoform ratio 0 0 1.06
Adipose intron excision ratio 0 0 1.04
Adipose mRNA stability 0 0 1.06
BLA alternative polyA 0 0 1.14
BLA alternative TSS 0 0 1.08
BLA gene expression 0 0 1.07
BLA isoform ratio 0 0 1.07
BLA intron excision ratio 0 0 1.02
BLA mRNA stability 0 0 1.06
Brain alternative polyA 0 0 1.12
Brain alternative TSS 0 0 1.07
Brain gene expression 0 0 1.08
Brain isoform ratio 0 0 1.09
Brain intron excision ratio 0 0 1.07
Brain mRNA stability 0 0 1.08
Eye alternative polyA 0 0 1.22
Eye alternative TSS 0 0 1.17
Eye gene expression 0 0 1.13
Eye isoform ratio 0 0 1.04
Eye intron excision ratio 0 0 0.95
Eye mRNA stability 0 0 1.08
IL alternative polyA 0 0 1.07
IL alternative TSS 0 0 1.02
IL gene expression 0 0 1.1
IL isoform ratio 0 0 1.07
IL intron excision ratio 0 0 1.07
IL mRNA stability 0 0 1.18
LHb alternative polyA 0 0 1.1
LHb alternative TSS 0 0 1.36
LHb gene expression 0 0 1.07
LHb isoform ratio 0 0 1.21
LHb intron excision ratio 0 0 1.02
LHb mRNA stability 0 0 1.11
Liver alternative polyA 0 0 1.16
Liver alternative TSS 0 0 1.18
Liver gene expression 0 0 1.09
Liver isoform ratio 0 0 1.14
Liver intron excision ratio 0 0 1.07
Liver mRNA stability 0 0 1.06
NAcc alternative polyA 0 0 1.1
NAcc alternative TSS 1 0 1.07
NAcc gene expression 0 0 1.09
NAcc isoform ratio 0 0 1.07
NAcc intron excision ratio 0 0 1.06
NAcc mRNA stability 1 0 1.09
OFC alternative polyA 0 0 1.14
OFC alternative TSS 0 0 1.13
OFC gene expression 0 0 1.06
OFC isoform ratio 0 0 1.05
OFC intron excision ratio 0 0 0.94
OFC mRNA stability 0 0 1.03
PL alternative polyA 0 0 1.12
PL alternative TSS 0 0 1.04
PL gene expression 0 0 1.06
PL isoform ratio 0 0 1.1
PL intron excision ratio 1 0 1.08
PL mRNA stability 0 0 1.1
pVTA alternative polyA 0 0 1.2
pVTA alternative TSS 0 0 1.14
pVTA gene expression 0 0 1.08
pVTA isoform ratio 0 0 1.14
pVTA intron excision ratio 0 0 1.06
pVTA mRNA stability 0 0 1.2
RMTg alternative polyA 0 0 1.09
RMTg alternative TSS 0 0 1.06
RMTg gene expression 0 0 1.09
RMTg isoform ratio 0 0 1.01
RMTg intron excision ratio 0 0 1.03
RMTg mRNA stability 0 0 1.23