Hub : Traits

Progressive ratio test 2 active lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

2 significantly associated models · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 39057816 40174684 1 1 6.3e-09 0.0068 1 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heart weight 4.4 1 0 0 0 1 Epha6
Parametrial fat weight 16.6 1 1 100 0 1 Epha6
Intraocular pressure 5.2 1 0 0 0 1 Epha6
Tibia length 2.1 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.4 1 0 0 0 1 Epha6
Times rat made contact with spout 14.7 1 0 0 0 1 Epha6
Water consumed over 24 hours 15.6 1 0 0 0 1 Epha6
Delay discounting total patch changes 12 sec 11.7 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 13.1 1 0 0 0 1 Epha6
Delay discounting total patch changes 6 sec 11.6 1 0 0 0 1 Epha6
Delay discounting water rate 18 sec 10.7 1 0 0 0 1 Epha6
Locomotor activity 6.9 1 0 0 0 1 Epha6
Locomotor testing distance 8.0 1 0 0 0 1 Epha6
Light reinforcement 2 4.0 1 0 0 0 1 Epha6
Reaction time premature initiation rate 8.8 1 0 0 0 1 Epha6
Reaction time premature initiations 5.0 1 0 0 0 1 Epha6
Social responses 4.0 1 0 0 0 1 Epha6
Conditioned locomotion 14.7 1 0 0 0 1 Epha6
Cocaine response before conditioning 6.7 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 6.0 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 5.2 1 0 0 0 1 Epha6
Pavlov. Cond. index score 4.0 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 5.6 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 5.4 1 0 0 0 1 Epha6
Pavlov. Cond. response bias 4.5 1 0 0 0 1 Epha6
Conditioned reinforcement - actives 21.1 1 0 0 0 1 Epha6
Conditioned reinforcement - inactives 27.0 1 1 100 0 1 Epha6
Intermittent access day 1 total infusions 10.6 1 0 0 0 1 Epha6
Intermittent access day 15 total infusions 13.7 1 0 0 0 1 Epha6
Intermittent access terminal intake (last 3 days) 19.4 1 0 0 0 1 Epha6
Intermittent access total infusions 17.6 1 0 0 0 1 Epha6
Cocaine induced anxiety 15.4 1 0 0 0 1 Epha6
Post-drug Anxiety 5.9 1 0 0 0 1 Epha6
Baseline Anxiety 18.8 1 0 0 0 1 Epha6
Lifetime Intake 31.6 1 1 100 0 1 Epha6
Incentive Sensitization - Responses 9.3 1 0 0 0 1 Epha6
Incentive Sensitization - Breakpoint 8.8 1 0 0 0 1 Epha6
Progressive ratio test 1 active lever presses 25.4 1 1 100 0 1 Epha6
Progressive ratio test 1 breakpoint 30.1 1 1 100 0 1 Epha6
Progressive ratio test 1 inactive lever presses 9.2 1 0 0 0 1 Epha6
Progressive ratio test 2 breakpoint 24.1 1 1 100 0 1 Epha6
Progressive ratio test 2 inactive lever presses 29.3 1 1 100 0 1 Epha6
Total sessions with >9 infusions 15.7 1 0 0 0 1 Epha6
Short access day 1 total inactive lever presses 6.6 1 0 0 0 1 Epha6
Short access day 1 total infusions 37.1 1 1 100 0 1 Epha6
Short access day 10 total infusions 5.0 1 0 0 0 1 Epha6
Short access total infusions 40.4 1 1 100 0 1 Epha6
One hour access (0.3 mA shock) 33.5 1 1 100 0 1 Epha6
One hour access (shock baseline) 19.6 1 0 0 0 1 Epha6
Locomotion distance, session 1 10.1 1 0 0 0 1 Epha6
Locomotion distance, session 2 3.6 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 7.0 1 0 0 0 1 Epha6
Stereotopy head waving duration, day 3 4.6 1 0 0 0 1 Epha6
Locomotion velocity, session 7 6.8 1 0 0 0 1 Epha6
Locomotion distance, session 7 12.3 1 0 0 0 1 Epha6
Locomotion distance, session 8 5.0 1 0 0 0 1 Epha6
Degree of sensitization distance 6.1 1 0 0 0 1 Epha6
Condit. Reinf. active minus inactive responses 7.1 1 0 0 0 1 Epha6
Condit. Reinf. active-inactive response ratio 8.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 7.5 1 0 0 0 1 Epha6
Incentive salience index mean 7.9 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 8.2 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 1 9.3 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.4 1 0 0 0 1 Epha6
Total zone transitions, hab. session 1 8.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 6.1 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 29.9 1 1 100 0 1 Epha6
Time in novel zone, hab. session 2 25.2 1 1 100 0 1 Epha6
Total zone transitions, hab. session 2 6.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 8.2 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 2 8.1 1 0 0 0 1 Epha6
Novelty place preference 5.6 1 0 0 0 1 Epha6
Total zone transitions, NPP test 3.7 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 14.6 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry latency 31.4 1 1 100 0 1 Epha6
Pavlov. Cond. change in total contacts 7.3 1 0 0 0 1 Epha6
Pavlov. Cond. index score 24.3 1 1 100 0 1 Epha6
Pavlov. Cond. latency score 22.4 1 1 100 0 1 Epha6
Pavlov. Cond. lever contacts 20.5 1 1 100 0 1 Epha6
Pavlov. Cond. magazine entry number 12.8 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 22.9 1 1 100 0 1 Epha6
Pavlov. Cond. response bias 24.6 1 1 100 0 1 Epha6
Bone surface 4.2 1 0 0 0 1 Epha6
Bone: connectivity density 4.0 1 0 0 0 1 Epha6
Bone: cortical porosity 5.6 1 0 0 0 1 Epha6
Bone: cortical thickness 13.4 1 0 0 0 1 Epha6
Bone: endosteal estimation 2.9 1 0 0 0 1 Epha6
Bone: marrow area 3.0 1 0 0 0 1 Epha6
Bone: maximum diameter 6.1 1 0 0 0 1 Epha6
Bone: periosteal estimation 2.8 1 0 0 0 1 Epha6
Bone: periosteal perimeter 4.0 1 0 0 0 1 Epha6
Bone: stiffness 7.0 1 0 0 0 1 Epha6
Time to tail flick, test, before self-admin 6.0 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 8.0 1 0 0 0 1 Epha6
Total heroin consumption 4.9 1 0 0 0 1 Epha6
Area under the delay curve 6.5 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.5 1 0 0 0 1 Epha6
Delay disc. indifference point, 4s delay 9.7 1 0 0 0 1 Epha6
Delay disc. indifference point, 8s delay 6.7 1 0 0 0 1 Epha6
Delay discount exponential model param 6.6 1 0 0 0 1 Epha6
Delay discount hyperbolic model param 6.7 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 1 6.0 1 0 0 0 1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 1 7.2 1 0 0 0 1 Epha6
Rest time, locomotor task time 2 5.7 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 2 4.8 1 0 0 0 1 Epha6
Seeking ratio, delayed vs. immediate footshock 11.1 1 0 0 0 1 Epha6
Locomotion in novel chamber post-restriction 15.3 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway 8.5 1 0 0 0 1 Epha6
Na content in liver 10.2 1 0 0 0 1 Epha6
Se content in liver 11.1 1 0 0 0 1 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.00 1.10
Adipose alternative TSS 0 0.00 1.14
Adipose gene expression 0 0.00 1.07
Adipose isoform ratio 0 0.00 1.07
Adipose intron excision ratio 0 0.00 1.03
Adipose mRNA stability 0 0.00 1.07
BLA alternative polyA 0 0.00 1.04
BLA alternative TSS 0 0.00 1.03
BLA gene expression 0 0.00 1.08
BLA isoform ratio 0 0.00 1.03
BLA intron excision ratio 0 0.00 1.04
BLA mRNA stability 0 0.00 1.05
Brain alternative polyA 0 0.00 1.07
Brain alternative TSS 0 0.00 1.05
Brain gene expression 0 0.00 1.08
Brain isoform ratio 0 0.00 1.10
Brain intron excision ratio 0 0.00 1.04
Brain mRNA stability 0 0.00 1.08
Eye alternative polyA 0 0.00 1.26
Eye alternative TSS 0 0.00 1.04
Eye gene expression 0 0.00 1.13
Eye isoform ratio 0 0.00 1.09
Eye intron excision ratio 0 0.00 1.01
Eye mRNA stability 0 0.00 1.24
IL alternative polyA 0 0.00 1.03
IL alternative TSS 0 0.00 0.94
IL gene expression 0 0.00 1.11
IL isoform ratio 0 0.00 1.02
IL intron excision ratio 0 0.00 1.07
IL mRNA stability 0 0.00 1.15
LHb alternative polyA 0 0.00 1.01
LHb alternative TSS 0 0.00 0.98
LHb gene expression 0 0.00 1.10
LHb isoform ratio 0 0.00 1.00
LHb intron excision ratio 0 0.00 1.02
LHb mRNA stability 0 0.00 1.08
Liver alternative polyA 0 0.00 1.01
Liver alternative TSS 0 0.00 1.06
Liver gene expression 0 0.00 1.06
Liver isoform ratio 0 0.00 1.10
Liver intron excision ratio 0 0.00 1.08
Liver mRNA stability 0 0.00 1.08
NAcc alternative polyA 0 0.00 1.01
NAcc alternative TSS 0 0.00 1.22
NAcc gene expression 0 0.00 1.08
NAcc isoform ratio 0 0.00 1.05
NAcc intron excision ratio 0 0.00 1.01
NAcc mRNA stability 0 0.00 1.08
OFC alternative polyA 0 0.00 0.98
OFC alternative TSS 0 0.00 1.08
OFC gene expression 0 0.00 1.13
OFC isoform ratio 0 0.00 1.01
OFC intron excision ratio 0 0.00 0.94
OFC mRNA stability 0 0.00 1.10
PL alternative polyA 0 0.00 1.06
PL alternative TSS 2 0.17 0.99
PL gene expression 0 0.00 1.08
PL isoform ratio 0 0.00 1.09
PL intron excision ratio 0 0.00 1.03
PL mRNA stability 0 0.00 1.10

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.