Tags: Physiology
Project: dissection
2 loci · 8 genes with independent associations · 126 total associated genes
| # | Chr | Start pos | End pos | # assoc genes | # joint models | Best TWAS P | Best GWAS P | Cond GWAS P | Joint genes |
|---|---|---|---|---|---|---|---|---|---|
| 1 | chr5 | 137680740 | 138752373 | 4 | 1 | 4.29e-08 | 3.14e-02 | 9.53e-06 | Stk40 |
| 2 | chr14 | 78151229 | 81951313 | 122 | 7 | 6.37e-13 | 2.19e-09 | 1.00e+00 | Ap1b1 Ddx56 Emid1 Gal3st1 Mtmr3 Pes1 |
| Trait | Chi2 ratio | # genes+ | # genes++ | % genes++ | Corr | Corr P | Genes |
|---|---|---|---|---|---|---|---|
| Liver weight, right | 8.96 | 5 | 0 | 0 | -1 | 5.78e-29 | Ddx56 Ogdh Pold2 Urgcp Zmiz2 |
| Extensor digitorum longus weight | 4.46 | 7 | 1 | 12.5 | 0.43 | 1.30e-01 | Aebp1 Ankrd36 Ddx56 Ogdh Pgam2 Stk40 Xbp1 |
| Soleus weight | 8.8 | 1 | 1 | 12.5 | -1 | 3.56e-04 | Stk40 |
| Patch foraging total patch changes 18 sec | 18.42 | 1 | 0 | 0 | -1 | 8.87e-04 | Stk40 |
| Patch foraging total patch changes 24 sec | 12.07 | 1 | 0 | 0 | 0 | 1.00e+00 | Stk40 |
| Locomotor testing distance | 8.84 | 1 | 0 | 0 | 0 | 1.00e+00 | Stk40 |
| Locomotor testing rearing | 13.4 | 1 | 0 | 0 | 1 | 3.49e-05 | Stk40 |
| Locomotion distance, session 8 | 9.59 | 2 | 0 | 0 | -1 | 0.00e+00 | Ascc2 Castor1 |
| Incentive salience index mean | 16.41 | 1 | 0 | 0 | -1 | 1.17e-03 | Stk40 |
| Condit. Reinf. lever presses | 11.91 | 1 | 0 | 0 | -1 | 1.10e-03 | Stk40 |
| Pavlov. Cond. lever latency | 11.35 | 1 | 0 | 0 | 0 | 1.00e+00 | Stk40 |
| Pavlov. Cond. intertrial magazine entries | 11.69 | 1 | 0 | 0 | 0 | 1.00e+00 | Stk40 |
| Bone surface | 9.17 | 1 | 0 | 0 | 0 | 1.00e+00 | Stk40 |
| Bone volume | 15.24 | 1 | 1 | 12.5 | -1 | 3.96e-04 | Stk40 |
| Sr content in liver | 72.91 | 1 | 1 | 12.5 | -1 | 9.00e-04 | Stk40 |
| Tissue | RNA modality | # hits | % hits/tests | Avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 6 | 0.2 | 1.52 |
| Adipose | alternative TSS | 2 | 0.1 | 1.41 |
| Adipose | gene expression | 12 | 0.1 | 1.5 |
| Adipose | isoform ratio | 9 | 0.2 | 1.51 |
| Adipose | intron excision ratio | 3 | 0.1 | 1.9 |
| Adipose | mRNA stability | 7 | 0.2 | 1.49 |
| BLA | alternative polyA | 5 | 0.2 | 1.65 |
| BLA | alternative TSS | 0 | 0 | 1.28 |
| BLA | gene expression | 6 | 0.1 | 1.49 |
| BLA | isoform ratio | 5 | 0.2 | 1.4 |
| BLA | intron excision ratio | 6 | 0.2 | 1.7 |
| BLA | mRNA stability | 4 | 0.2 | 1.5 |
| Brain | alternative polyA | 6 | 0.2 | 1.51 |
| Brain | alternative TSS | 7 | 0.2 | 1.48 |
| Brain | gene expression | 9 | 0.1 | 1.52 |
| Brain | isoform ratio | 9 | 0.2 | 1.5 |
| Brain | intron excision ratio | 9 | 0.2 | 1.71 |
| Brain | mRNA stability | 7 | 0.1 | 1.47 |
| Eye | alternative polyA | 0 | 0 | 1.62 |
| Eye | alternative TSS | 0 | 0 | 1.47 |
| Eye | gene expression | 0 | 0 | 1.66 |
| Eye | isoform ratio | 0 | 0 | 1.37 |
| Eye | intron excision ratio | 0 | 0 | 1.8 |
| Eye | mRNA stability | 1 | 0.3 | 1.56 |
| IL | alternative polyA | 0 | 0 | 1.46 |
| IL | alternative TSS | 0 | 0 | 1.35 |
| IL | gene expression | 5 | 0.1 | 1.46 |
| IL | isoform ratio | 1 | 0.1 | 1.42 |
| IL | intron excision ratio | 1 | 0.1 | 1.56 |
| IL | mRNA stability | 4 | 0.3 | 1.49 |
| LHb | alternative polyA | 0 | 0 | 1.59 |
| LHb | alternative TSS | 0 | 0 | 1.3 |
| LHb | gene expression | 6 | 0.2 | 1.52 |
| LHb | isoform ratio | 3 | 0.2 | 1.63 |
| LHb | intron excision ratio | 0 | 0 | 1.84 |
| LHb | mRNA stability | 2 | 0.2 | 1.45 |
| Liver | alternative polyA | 8 | 0.3 | 1.46 |
| Liver | alternative TSS | 1 | 0 | 1.43 |
| Liver | gene expression | 8 | 0.1 | 1.47 |
| Liver | isoform ratio | 6 | 0.2 | 1.45 |
| Liver | intron excision ratio | 6 | 0.1 | 1.62 |
| Liver | mRNA stability | 7 | 0.2 | 1.5 |
| NAcc | alternative polyA | 5 | 0.2 | 1.62 |
| NAcc | alternative TSS | 1 | 0 | 1.32 |
| NAcc | gene expression | 9 | 0.1 | 1.5 |
| NAcc | isoform ratio | 8 | 0.2 | 1.5 |
| NAcc | intron excision ratio | 6 | 0.1 | 1.51 |
| NAcc | mRNA stability | 5 | 0.2 | 1.47 |
| OFC | alternative polyA | 0 | 0 | 1.52 |
| OFC | alternative TSS | 0 | 0 | 1.28 |
| OFC | gene expression | 4 | 0.1 | 1.45 |
| OFC | isoform ratio | 0 | 0 | 1.48 |
| OFC | intron excision ratio | 0 | 0 | 1.66 |
| OFC | mRNA stability | 5 | 0.4 | 1.47 |
| PL | alternative polyA | 5 | 0.2 | 1.51 |
| PL | alternative TSS | 0 | 0 | 1.34 |
| PL | gene expression | 8 | 0.1 | 1.47 |
| PL | isoform ratio | 7 | 0.1 | 1.49 |
| PL | intron excision ratio | 10 | 0.2 | 1.53 |
| PL | mRNA stability | 4 | 0.1 | 1.46 |
| pVTA | alternative polyA | 0 | 0 | 1.6 |
| pVTA | alternative TSS | 0 | 0 | 1.33 |
| pVTA | gene expression | 6 | 0.1 | 1.51 |
| pVTA | isoform ratio | 1 | 0 | 1.47 |
| pVTA | intron excision ratio | 3 | 0.1 | 1.48 |
| pVTA | mRNA stability | 2 | 0.1 | 1.46 |
| RMTg | alternative polyA | 0 | 0 | 1.61 |
| RMTg | alternative TSS | 0 | 0 | 1.41 |
| RMTg | gene expression | 1 | 0.1 | 1.5 |
| RMTg | isoform ratio | 1 | 0.2 | 1.43 |
| RMTg | intron excision ratio | 1 | 0.1 | 1.88 |
| RMTg | mRNA stability | 0 | 0 | 1.64 |