Glucose

Tags: Physiology

2 loci · 8 genes with independent associations · 40 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	5	137682119	138752373	1	1	1.21e-09	3.14e-02	6.65e-01	Stk40
2	14	78047795	81951313	39	7	7.30e-13	2.19e-09	1.00e+00	Ddx56 Sf3a1 Tbc1d10a Nf2 Ap1b1 Ewsr1 Aebp1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI with tail	4.29	1	0	0	0	1.00e+00	Stk40
Body weight	4.02	1	0	0	0	1.00e+00	Stk40
Liver weight, right	8.82	5	0	0	-1	8.74e-15	Ddx56 Ogdh Mrps24 Zmiz2 Npc1l1
Extensor digitorum longus weight	3.57	7	0	0	0.75	3.03e-03	Ewsr1 Xbp1 Mrps24 Pgam2 Polm Stk40 Nudcd3
Soleus weight	14.02	1	1	12.5	0	1.00e+00	Stk40
Locomotor testing rearing	15	1	0	0	0	1.00e+00	Stk40
Reaction time num false alarms AUC	11.52	1	0	0	0	1.00e+00	Stk40
Locomotion distance, session 8	9.17	5	0	0	-1	1.54e-15	Sec14l2 Sf3a1 Castor1 Ewsr1 Xbp1
Condit. Reinf. active minus inactive responses	14.65	1	0	0	0	1.00e+00	Stk40
Incentive salience index mean	28.28	1	1	12.5	0	1.00e+00	Stk40
Condit. Reinf. lever presses	24.79	1	1	12.5	0	1.00e+00	Stk40
Pavlov. Cond. lever latency	13.9	1	0	0	0	1.00e+00	Stk40
Pavlov. Cond. intertrial magazine entries	12.34	1	0	0	0	1.00e+00	Stk40
Pavlov. Cond. lever-magazine prob. diff.	11.11	1	0	0	0	1.00e+00	Stk40
Bone: apparent density	13.14	1	0	0	0	1.00e+00	Stk40
Bone surface	18.86	1	1	12.5	0	1.00e+00	Stk40
Bone volume	28.24	1	1	12.5	0	1.00e+00	Stk40
Bone: endosteal estimation	6.58	1	0	0	0	1.00e+00	Stk40
Bone: marrow area	6.24	1	0	0	0	1.00e+00	Stk40
Bone: maximum diameter	7.45	1	0	0	0	1.00e+00	Tbc1d10a
Mg content in liver	13.66	1	0	0	0	1.00e+00	Stk40
Se content in liver	12.67	1	0	0	0	1.00e+00	Stk40
Sr content in liver	132.45	1	1	12.5	0	1.00e+00	Stk40

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	1.36
Adipose	alternative TSS	1	0.1	1.44
Adipose	gene expression	12	0.1	1.51
Adipose	isoform ratio	3	0.1	1.46
Adipose	intron excision ratio	3	0.1	1.79
Adipose	mRNA stability	6	0.2	1.46
BLA	alternative polyA	0	0	1.35
BLA	alternative TSS	0	0	1.55
BLA	gene expression	5	0.1	1.52
BLA	isoform ratio	2	0.1	1.6
BLA	intron excision ratio	4	0.1	1.58
BLA	mRNA stability	2	0.1	1.5
Brain	alternative polyA	0	0	1.38
Brain	alternative TSS	2	0.1	1.55
Brain	gene expression	14	0.2	1.52
Brain	isoform ratio	6	0.2	1.59
Brain	intron excision ratio	8	0.1	1.67
Brain	mRNA stability	7	0.2	1.49
Eye	alternative polyA	0	0	1.43
Eye	alternative TSS	0	0	1.42
Eye	gene expression	1	0.1	1.65
Eye	isoform ratio	5	1.4	2.24
Eye	intron excision ratio	0	0	1.54
Eye	mRNA stability	1	0.4	1.79
IL	alternative polyA	0	0	1.42
IL	alternative TSS	0	0	1.23
IL	gene expression	4	0.1	1.49
IL	isoform ratio	2	0.3	1.64
IL	intron excision ratio	0	0	1.4
IL	mRNA stability	3	0.3	1.46
LHb	alternative polyA	0	0	1.47
LHb	alternative TSS	0	0	1.36
LHb	gene expression	5	0.2	1.55
LHb	isoform ratio	3	0.4	1.64
LHb	intron excision ratio	0	0	1.67
LHb	mRNA stability	3	0.3	1.57
Liver	alternative polyA	0	0	1.29
Liver	alternative TSS	4	0.3	1.49
Liver	gene expression	9	0.1	1.48
Liver	isoform ratio	6	0.3	1.5
Liver	intron excision ratio	5	0.1	1.64
Liver	mRNA stability	4	0.2	1.57
NAcc	alternative polyA	1	0.1	1.53
NAcc	alternative TSS	0	0	1.47
NAcc	gene expression	5	0.1	1.5
NAcc	isoform ratio	5	0.3	1.74
NAcc	intron excision ratio	5	0.2	1.59
NAcc	mRNA stability	6	0.3	1.51
OFC	alternative polyA	0	0	1.42
OFC	alternative TSS	0	0	1.45
OFC	gene expression	4	0.1	1.5
OFC	isoform ratio	2	0.2	1.73
OFC	intron excision ratio	0	0	1.71
OFC	mRNA stability	5	0.5	1.54
PL	alternative polyA	0	0	1.49
PL	alternative TSS	0	0	1.48
PL	gene expression	8	0.1	1.48
PL	isoform ratio	6	0.3	1.59
PL	intron excision ratio	5	0.1	1.69
PL	mRNA stability	4	0.1	1.5