Hub : Traits

Glucose

Tags: Physiology

Project: dissection

188 significantly associated models · 40 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 137682119 138752373 1 1 1.2e-09 3.1e-02 0.66 96 Stk40
2 14 78047795 81951313 39 7 7.3e-13 2.2e-09 1.00 100 Ddx56 Sf3a1 Tbc1d10a Nf2 Ap1b1 Ewsr1 Aebp1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 4.3 1 0 0 0.00 1.0e+00 Stk40
Body weight 4.0 1 0 0 0.00 1.0e+00 Stk40
Liver weight, right 8.8 5 0 0 -1.00 8.7e-15 Ddx56 Ogdh Mrps24 Zmiz2 Npc1l1
Extensor digitorum longus weight 3.6 7 0 0 0.75 3.0e-03 Ewsr1 Xbp1 Mrps24 Pgam2 Polm Stk40 Nudcd3
Soleus weight 14.0 1 1 12 0.00 1.0e+00 Stk40
Locomotor testing rearing 15.0 1 0 0 0.00 1.0e+00 Stk40
Reaction time num false alarms AUC 11.5 1 0 0 0.00 1.0e+00 Stk40
Locomotion distance, session 8 9.2 5 0 0 -1.00 1.5e-15 Sec14l2 Sf3a1 Castor1 Ewsr1 Xbp1
Condit. Reinf. active minus inactive responses 14.7 1 0 0 0.00 1.0e+00 Stk40
Incentive salience index mean 28.3 1 1 12 0.00 1.0e+00 Stk40
Condit. Reinf. lever presses 24.8 1 1 12 0.00 1.0e+00 Stk40
Pavlov. Cond. lever latency 13.9 1 0 0 0.00 1.0e+00 Stk40
Pavlov. Cond. intertrial magazine entries 12.3 1 0 0 0.00 1.0e+00 Stk40
Pavlov. Cond. lever-magazine prob. diff. 11.1 1 0 0 0.00 1.0e+00 Stk40
Bone: apparent density 13.1 1 0 0 0.00 1.0e+00 Stk40
Bone surface 18.9 1 1 12 0.00 1.0e+00 Stk40
Bone volume 28.2 1 1 12 0.00 1.0e+00 Stk40
Bone: endosteal estimation 6.6 1 0 0 0.00 1.0e+00 Stk40
Bone: marrow area 6.2 1 0 0 0.00 1.0e+00 Stk40
Bone: maximum diameter 7.5 1 0 0 0.00 1.0e+00 Tbc1d10a
Mg content in liver 13.7 1 0 0 0.00 1.0e+00 Stk40
Se content in liver 12.7 1 0 0 0.00 1.0e+00 Stk40
Sr content in liver 132.4 1 1 12 0.00 1.0e+00 Stk40

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 2 0.094 1.4
Adipose alternative TSS 1 0.062 1.4
Adipose gene expression 12 0.145 1.5
Adipose isoform ratio 3 0.106 1.5
Adipose intron excision ratio 3 0.103 1.8
Adipose mRNA stability 6 0.174 1.5
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.5
BLA gene expression 5 0.083 1.5
BLA isoform ratio 2 0.114 1.6
BLA intron excision ratio 4 0.134 1.6
BLA mRNA stability 2 0.099 1.5
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 2 0.116 1.5
Brain gene expression 14 0.155 1.5
Brain isoform ratio 6 0.190 1.6
Brain intron excision ratio 8 0.148 1.7
Brain mRNA stability 7 0.160 1.5
Eye alternative polyA 0 0.000 1.4
Eye alternative TSS 0 0.000 1.4
Eye gene expression 1 0.089 1.6
Eye isoform ratio 5 1.412 2.2
Eye intron excision ratio 0 0.000 1.5
Eye mRNA stability 1 0.431 1.8
IL alternative polyA 0 0.000 1.4
IL alternative TSS 0 0.000 1.2
IL gene expression 4 0.110 1.5
IL isoform ratio 2 0.253 1.6
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 3 0.270 1.5
LHb alternative polyA 0 0.000 1.5
LHb alternative TSS 0 0.000 1.4
LHb gene expression 5 0.156 1.5
LHb isoform ratio 3 0.398 1.6
LHb intron excision ratio 0 0.000 1.7
LHb mRNA stability 3 0.290 1.6
Liver alternative polyA 0 0.000 1.3
Liver alternative TSS 4 0.264 1.5
Liver gene expression 9 0.125 1.5
Liver isoform ratio 6 0.251 1.5
Liver intron excision ratio 5 0.114 1.6
Liver mRNA stability 4 0.163 1.6
NAcc alternative polyA 1 0.076 1.5
NAcc alternative TSS 0 0.000 1.5
NAcc gene expression 5 0.079 1.5
NAcc isoform ratio 5 0.266 1.7
NAcc intron excision ratio 5 0.163 1.6
NAcc mRNA stability 6 0.265 1.5
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.4
OFC gene expression 4 0.108 1.5
OFC isoform ratio 2 0.245 1.7
OFC intron excision ratio 0 0.000 1.7
OFC mRNA stability 5 0.463 1.5
PL alternative polyA 0 0.000 1.5
PL alternative TSS 0 0.000 1.5
PL gene expression 8 0.108 1.5
PL isoform ratio 6 0.272 1.6
PL intron excision ratio 5 0.140 1.7
PL mRNA stability 4 0.137 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.