Hub : Traits

The total number of resting periods in time1

A resting period is defined as a period of inactivity greater than or equal to 1 second.

Project: u01_suzanne_mitchell

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 1.1e-10 0.22 3.4e-09 -2223 Syt5

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 1.2 1 0 0 0 1 Syt5
body_g 2.6 1 0 0 0 1 Syt5
dissection: UMAP 3 of all traits 3.0 1 0 0 0 1 Syt5
kidney_right_g 2.6 1 0 0 0 1 Syt5
glucose_mg_dl 12.1 1 0 0 0 1 Syt5
Tibia length in mm 7.5 1 0 0 0 1 Syt5
TA weight in grams 2.4 1 0 0 0 1 Syt5
Std. dev. time between licks in bursts 22.8 1 1 100 0 1 Syt5
Water consumed over 24 hour session 3.9 1 0 0 0 1 Syt5
Average drop size 12.2 1 0 0 0 1 Syt5
light_reinforcement_lr_relactive 21.5 1 1 100 0 1 Syt5
light_reinforcement_lr_active 21.5 1 1 100 0 1 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0 1 Syt5
Median of all reaction times 7.0 1 0 0 0 1 Syt5
social_reinforcement_socialrfq 8.0 1 0 0 0 1 Syt5
reaction_time_pinit_slope 9.7 1 0 0 0 1 Syt5
reaction_time_peropfalsealarm_slope 11.6 1 0 0 0 1 Syt5
reaction_time_meanrt_slope 15.7 1 0 0 0 1 Syt5
reaction_time_devmedrt_slope 42.2 1 1 100 0 1 Syt5
ccp_trial_3_saline_dist_mm 23.3 1 1 100 0 1 Syt5
ccp_change_in_locomotor_activity 5.9 1 0 0 0 1 Syt5
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
pavca_mi_d1_avg_mag_lat 5.4 1 0 0 0 1 Syt5
pavca_mi_d3_magazine_ncs 5.2 1 0 0 0 1 Syt5
tb_th_sd 6.3 1 0 0 0 1 Syt5
Trabecular tissue density 8.2 1 0 0 0 1 Syt5
ctth_sd 7.8 1 0 0 0 1 Syt5
tautz: manual_mpc18 7.6 1 0 0 0 1 Syt5
tautz: manual_spc15 11.6 1 0 0 0 1 Syt5
tautz: manual_spc21 5.5 1 0 0 0 1 Syt5
tautz: manual_spc9 24.1 1 1 100 0 1 Syt5
tautz: manual_mpc3 8.8 1 0 0 0 1 Syt5
tautz: manual_spc12 20.2 1 1 100 0 1 Syt5
tautz: manual_spc14 8.9 1 0 0 0 1 Syt5
tautz: manual_mpc7 6.5 1 0 0 0 1 Syt5
tautz: manual_mpc16 2.9 1 0 0 0 1 Syt5
tautz: manual_mpc4 23.9 1 1 100 0 1 Syt5
tautz: manual_mpc10 7.8 1 0 0 0 1 Syt5
tautz: manual_mpc5 23.6 1 1 100 0 1 Syt5
tautz: manual_spc22 69.7 1 1 100 0 1 Syt5
tautz: manual_mpc12 25.5 1 1 100 0 1 Syt5
tautz: manual_spc24 8.0 1 0 0 0 1 Syt5
tautz: manual_mpc19 32.6 1 1 100 0 1 Syt5
tautz: manual_spc10 19.2 1 0 0 0 1 Syt5
tautz: manual_spc23 10.7 1 0 0 0 1 Syt5
tautz: manual_spc6 49.4 1 1 100 0 1 Syt5
tautz: manual_mpc17 3.0 1 0 0 0 1 Syt5
tautz: manual_spc1 10.7 1 0 0 0 1 Syt5
tautz: manual_spc16 5.2 1 0 0 0 1 Syt5
tautz: manual_spc5 17.8 1 0 0 0 1 Syt5
tautz: manual_spc3 11.2 1 0 0 0 1 Syt5
tautz: manual_spc19 11.8 1 0 0 0 1 Syt5
Sum of all infusions from LGA sessions 5.8 1 0 0 0 1 Syt5
Ambulatory time at time1 of open field 36.6 1 1 100 0 1 Syt5
punishment 133.8 1 1 100 0 1 Syt5
Weight adjusted by age 8.2 1 0 0 0 1 Syt5
Liver rubidium concentration 6.5 1 0 0 0 1 Syt5
Liver iron concentration 3.6 1 0 0 0 1 Syt5
Liver cobalt concentration 19.4 1 0 0 0 1 Syt5
Liver cadmium concentration 7.7 1 0 0 0 1 Syt5
Liver zinc concentration 12.4 1 0 0 0 1 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.08
Adipose alternative TSS 0 0.000 1.21
Adipose gene expression 0 0.000 1.11
Adipose isoform ratio 0 0.000 1.12
Adipose intron excision ratio 0 0.000 1.19
Adipose mRNA stability 0 0.000 1.13
BLA alternative polyA 0 0.000 0.99
BLA alternative TSS 0 0.000 1.20
BLA gene expression 0 0.000 1.12
BLA isoform ratio 0 0.000 1.08
BLA intron excision ratio 0 0.000 1.14
BLA mRNA stability 1 0.049 1.11
Brain alternative polyA 0 0.000 1.09
Brain alternative TSS 0 0.000 1.20
Brain gene expression 0 0.000 1.12
Brain isoform ratio 0 0.000 1.10
Brain intron excision ratio 0 0.000 1.11
Brain mRNA stability 0 0.000 1.09
Eye alternative polyA 0 0.000 0.84
Eye alternative TSS 0 0.000 1.22
Eye gene expression 0 0.000 1.11
Eye isoform ratio 0 0.000 1.11
Eye intron excision ratio 0 0.000 1.15
Eye mRNA stability 0 0.000 1.25
IL alternative polyA 0 0.000 1.11
IL alternative TSS 0 0.000 1.19
IL gene expression 0 0.000 1.11
IL isoform ratio 0 0.000 1.17
IL intron excision ratio 0 0.000 1.12
IL mRNA stability 0 0.000 1.12
LHb alternative polyA 0 0.000 1.03
LHb alternative TSS 0 0.000 1.22
LHb gene expression 0 0.000 1.10
LHb isoform ratio 0 0.000 1.14
LHb intron excision ratio 0 0.000 1.09
LHb mRNA stability 0 0.000 1.17
Liver alternative polyA 0 0.000 1.04
Liver alternative TSS 0 0.000 1.02
Liver gene expression 0 0.000 1.12
Liver isoform ratio 0 0.000 1.09
Liver intron excision ratio 0 0.000 1.10
Liver mRNA stability 0 0.000 1.15
NAcc alternative polyA 0 0.000 1.13
NAcc alternative TSS 0 0.000 1.18
NAcc gene expression 0 0.000 1.12
NAcc isoform ratio 0 0.000 1.10
NAcc intron excision ratio 0 0.000 1.12
NAcc mRNA stability 0 0.000 1.06
NAcc2 alternative polyA 0 0.000 1.04
NAcc2 alternative TSS 0 0.000 1.23
NAcc2 gene expression 0 0.000 1.11
NAcc2 isoform ratio 0 0.000 1.10
NAcc2 intron excision ratio 0 0.000 1.10
NAcc2 mRNA stability 0 0.000 1.10
OFC alternative polyA 0 0.000 1.05
OFC alternative TSS 0 0.000 0.99
OFC gene expression 0 0.000 1.12
OFC isoform ratio 0 0.000 1.06
OFC intron excision ratio 0 0.000 1.21
OFC mRNA stability 0 0.000 1.18
PL alternative polyA 0 0.000 0.95
PL alternative TSS 0 0.000 1.05
PL gene expression 0 0.000 1.12
PL isoform ratio 0 0.000 1.07
PL intron excision ratio 0 0.000 1.08
PL mRNA stability 0 0.000 1.07
PL2 alternative polyA 0 0.000 0.99
PL2 alternative TSS 0 0.000 1.25
PL2 gene expression 0 0.000 1.12
PL2 isoform ratio 0 0.000 1.11
PL2 intron excision ratio 0 0.000 1.15
PL2 mRNA stability 0 0.000 1.10

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.