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Diff in mean of infusions in LGA sessions

Difference between mean of infusions from LGA sessions 10 through 12 and mean of LGA sessions 1 through 3

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr10	35140534	36539678	1	1	6.04e-10	2.08e-06	3.07e-01	Phykpl

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Soleus weight	1.41	1	0	0	0	1e+00	Phykpl
Reaction time number correct	2.73	1	0	0	0	1e+00	Phykpl
Reaction time trials correct on left	2.73	1	0	0	0	1e+00	Phykpl
Reaction time trials AUC	3.27	1	0	0	0	1e+00	Phykpl
Condit. Reinf. active minus inactive responses	3.15	1	0	0	0	1e+00	Phykpl
Intermittent access intake day 1-15 change	8.11	1	0	0	0	1e+00	Phykpl
Intermittent access intake escalation	7.21	1	0	0	0	1e+00	Phykpl
Intermittent access intake escalation 2	7.18	1	0	0	0	1e+00	Phykpl
Intermittent access day 15 total infusions	4.7	1	0	0	0	1e+00	Phykpl
Intermittent access terminal intake (last 3 days)	3.52	1	0	0	0	1e+00	Phykpl
Short access day 10 total locomotion	8.29	1	0	0	0	1e+00	Phykpl
Compulsive drug intake	7.28	1	0	0	0	1e+00	Phykpl
Bone: final force	2.56	1	0	0	0	1e+00	Phykpl
Bone: trabecular thickness	3.73	1	0	0	0	1e+00	Phykpl
Breakpoint value in progressive ratio session	14.31	1	0	0	0	1e+00	Phykpl
Extinction: sum of active levers before priming	13.64	1	0	0	0	1e+00	Phykpl
Active lever presses in extinction session 6	4.21	1	0	0	0	1e+00	Phykpl
Time in closed arm before self-admin	4.43	1	0	0	0	1e+00	Phykpl
Time in closed arm after self-admin	6.15	1	0	0	0	1e+00	Phykpl
Time in open arm before self-admin	6.25	1	0	0	0	1e+00	Phykpl
Time in open arm after self-admin	7.54	1	0	0	0	1e+00	Phykpl
Sum of active levers in priming session hrs 5-6	23.73	1	0	0	0	1e+00	Phykpl
Time to tail flick, test, before self-admin	8.36	1	0	0	0	1e+00	Phykpl
Total heroin consumption	13.9	1	0	0	0	1e+00	Phykpl
Bouts of movement, locomotor time 1	5.25	1	0	0	0	1e+00	Phykpl
Total resting periods, locomotor time 1	4.39	1	0	0	0	1e+00	Phykpl
Latency to leave start box in cocaine runway, M	6.46	1	0	0	0	1e+00	Phykpl

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.07
Adipose	alternative TSS	0	0	1.12
Adipose	gene expression	0	0	1.1
Adipose	isoform ratio	0	0	1.11
Adipose	intron excision ratio	0	0	1.11
Adipose	mRNA stability	0	0	1.12
BLA	alternative polyA	0	0	1.02
BLA	alternative TSS	0	0	1.11
BLA	gene expression	0	0	1.09
BLA	isoform ratio	0	0	1.06
BLA	intron excision ratio	0	0	1.13
BLA	mRNA stability	0	0	1.1
Brain	alternative polyA	0	0	1.03
Brain	alternative TSS	0	0	1.08
Brain	gene expression	0	0	1.08
Brain	isoform ratio	0	0	1.08
Brain	intron excision ratio	0	0	1.13
Brain	mRNA stability	0	0	1.1
Eye	alternative polyA	0	0	1.17
Eye	alternative TSS	0	0	1.21
Eye	gene expression	0	0	1.05
Eye	isoform ratio	0	0	1.11
Eye	intron excision ratio	0	0	1.22
Eye	mRNA stability	0	0	1.13
IL	alternative polyA	0	0	1
IL	alternative TSS	0	0	1.13
IL	gene expression	0	0	1.09
IL	isoform ratio	0	0	1.05
IL	intron excision ratio	0	0	1.34
IL	mRNA stability	0	0	1.12
LHb	alternative polyA	0	0	1.07
LHb	alternative TSS	0	0	1.21
LHb	gene expression	0	0	1.13
LHb	isoform ratio	0	0	1.15
LHb	intron excision ratio	0	0	1.37
LHb	mRNA stability	0	0	1.11
Liver	alternative polyA	0	0	1.01
Liver	alternative TSS	0	0	1.14
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.12
Liver	intron excision ratio	0	0	1.08
Liver	mRNA stability	0	0	1.12
NAcc	alternative polyA	0	0	1.04
NAcc	alternative TSS	0	0	1.06
NAcc	gene expression	0	0	1.09
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.17
NAcc	mRNA stability	1	0	1.15
OFC	alternative polyA	0	0	1.03
OFC	alternative TSS	0	0	1.12
OFC	gene expression	0	0	1.14
OFC	isoform ratio	0	0	1.15
OFC	intron excision ratio	0	0	1.33
OFC	mRNA stability	0	0	1.12
PL	alternative polyA	0	0	1.04
PL	alternative TSS	0	0	1.1
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.09
PL	intron excision ratio	0	0	1.17
PL	mRNA stability	0	0	1.11
pVTA	alternative polyA	0	0	1.14
pVTA	alternative TSS	0	0	1.12
pVTA	gene expression	0	0	1.11
pVTA	isoform ratio	0	0	1.09
pVTA	intron excision ratio	0	0	1.24
pVTA	mRNA stability	0	0	1.11
RMTg	alternative polyA	0	0	1.06
RMTg	alternative TSS	0	0	1.2
RMTg	gene expression	0	0	1.12
RMTg	isoform ratio	0	0	1.08
RMTg	intron excision ratio	0	0	1.12
RMTg	mRNA stability	0	0	1.07