Hub : Genes

Folr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Folr2 0.06 0.04 7.0e-05 0.03 0.02 0.02 0.02 4.4e-04 1.7e-03 4.2e-03 1.2e-03
2 PL gene expression Folr2 0.06 0.04 3.4e-04 0.03 0.03 0.02 0.02 5.0e-04 8.4e-04 2.5e-03 2.1e-03
3 BLA gene expression Folr2 0.13 0.09 5.1e-04 0.05 0.06 0.07 0.06 1.1e-03 3.7e-04 1.2e-04 3.2e-04
4 Liver gene expression Folr2 0.35 0.14 0.0e+00 0.16 0.22 0.21 0.22 6.6e-17 7.1e-24 2.3e-23 1.2e-23
5 Adipose alternative TSS XM_039106129.2 0.06 0.04 6.4e-05 0.02 0.02 0.02 0.02 2.2e-03 1.5e-03 2.1e-03 2.0e-03
6 NAcc gene expression Folr2 0.04 0.03 3.5e-05 0.02 0.03 0.03 0.03 3.8e-04 8.2e-06 5.6e-05 7.9e-05
7 Brain gene expression Folr2 0.04 0.04 2.7e-03 0.03 0.02 0.02 0.02 8.4e-04 3.5e-03 2.9e-03 3.4e-03
8 Adipose intron excision ratio chr1_165613053_165616147 0.04 0.03 1.2e-03 0.02 0.02 0.01 0.02 2.7e-03 2.8e-03 9.4e-03 4.4e-03
9 Adipose alternative TSS XM_006229858.4 0.06 0.04 1.1e-04 0.01 0.02 0.02 0.02 9.7e-03 3.7e-03 2.8e-03 4.6e-03
10 Adipose alternative TSS XM_006229858.4 0.2 0.11 5.6e-17 0.12 0.12 0.11 0.12 9.2e-14 2.8e-13 4.6e-12 2.8e-13
11 Adipose alternative TSS XM_039106129.2 0.19 0.11 1.7e-16 0.12 0.12 0.11 0.12 2.2e-13 5.2e-13 5.8e-12 6.9e-13
12 Liver isoform ratio XM_006229858.4 0.04 0.03 3.7e-04 0.02 0.01 0.02 0.01 2.1e-03 1.2e-02 5.7e-03 9.6e-03
13 Adipose mRNA stability Folr2 0.23 0.14 0.0e+00 0.11 0.13 0.12 0.12 3.6e-12 3.8e-14 8.9e-13 2.1e-13
14 IL gene expression Folr2 0.19 0.12 5.7e-03 0.06 0.04 -0 0.02 1.4e-02 4.5e-02 3.8e-01 9.1e-02
15 Adipose isoform ratio XM_006229858.4 0.29 0.13 0.0e+00 0.21 0.21 0.2 0.21 3.9e-23 2.0e-22 3.9e-22 1.1e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.41.4-0.6-0.6-0.10.5-0.60.6-1.11.2-0.0-0.60.60.40.3-0.40.3
Area under the delay curve0.20.21.2-0.6-0.60.10.1-0.10.10.20.21.00.3-0.3-0.41.10.3-0.4
BMI with tail0.82.97.1-0.4-0.3-2.31.9-1.41.41.3-0.6-1.1-1.11.12.5-2.7-2.42.3
BMI without tail0.31.56.51.51.5-0.3-0.10.4-0.41.8-1.7-1.50.0-0.00.9-2.6-0.90.9
Body weight0.41.98.21.11.20.4-0.71.1-1.12.9-2.70.51.7-1.7-0.3-0.80.4-0.4
Weight adjusted by age0.20.51.50.91.20.8-0.80.8-0.80.4-0.70.10.6-0.6-0.6-0.30.7-0.4
Bone surface0.51.13.71.01.01.9-1.31.1-1.10.3-0.30.21.0-1.0-1.00.51.1-1.0
Bone volume0.30.61.90.70.51.4-0.90.8-0.80.4-0.30.40.8-0.8-0.90.60.9-0.8
Breakpoint value in progressive ratio session0.40.81.9-1.0-1.2-1.41.1-1.01.0-0.40.5-0.2-0.90.90.8-0.2-0.91.0
Number of licking bursts0.72.15.7-2.3-2.4-2.01.9-1.71.6-0.60.91.3-0.80.80.81.0-0.80.9
Context. condit. distance diff. score1.31.54.92.22.21.4-1.51.3-1.20.3-0.7-1.70.4-0.4-0.2-1.50.3-0.0
Locomotion velocity, session 12.22.43.6-0.8-0.9-1.71.5-1.61.6-1.51.8-1.3-1.91.91.7-1.2-1.81.9
Locomotion distance, session 10.70.93.50.70.6-0.20.2-0.30.3-0.50.7-1.9-1.01.01.0-1.7-1.01.0
Locomotion velocity, session 20.60.72.10.2-0.0-0.70.6-0.60.60.00.1-1.2-0.90.91.0-1.4-1.11.3
Locomotion distance, session 20.60.93.20.40.3-0.80.5-0.50.50.2-0.0-1.6-1.01.01.1-1.8-1.21.3
Locomotion velocity, session 30.30.31.11.00.60.8-0.80.6-0.6-0.1-0.0-0.80.0-0.0-0.4-0.40.4-0.2
Locomotion distance, session 30.40.41.71.00.71.0-0.60.4-0.3-0.80.6-1.3-0.40.4-0.0-0.70.00.2
Stereotopy head waving bouts, day 30.40.51.3-0.30.00.1-0.30.4-0.51.0-0.91.10.8-0.8-0.70.90.7-0.9
Stereotopy head waving duration, day 30.10.10.60.40.80.1-0.20.2-0.20.10.1-0.6-0.10.10.1-0.5-0.1-0.2
Locomotion velocity, session 70.70.81.5-0.3-0.4-1.10.8-0.90.9-0.70.5-0.8-1.11.11.1-1.0-1.11.2
Locomotion distance, session 70.10.10.3-0.5-0.6-0.50.4-0.30.30.2-0.20.4-0.10.10.10.3-0.10.3
Stereotopy head waving bouts, day 71.61.85.22.22.32.3-1.81.5-1.40.0-0.2-1.40.5-0.5-0.7-1.00.8-0.7
Stereotopy head waving duration, day 71.41.75.32.22.32.0-1.61.4-1.30.1-0.3-1.50.4-0.4-0.5-1.20.6-0.6
Locomotion velocity, session 80.70.92.41.61.21.3-1.21.1-1.10.7-0.8-0.80.6-0.6-0.7-0.60.6-0.1
Locomotion distance, session 81.01.54.62.11.90.8-1.01.0-0.90.8-0.9-2.10.0-0.00.3-2.1-0.30.5
Degree of sensitization distance1.11.24.1-0.4-0.3-0.3-0.10.5-0.62.0-1.81.71.3-1.3-0.81.00.8-0.8
Degree of sensitization stereotypy2.93.28.73.02.92.8-2.32.0-1.90.3-0.5-1.80.8-0.8-1.0-1.31.1-0.8
Conditioned locomotion0.40.51.6-0.5-0.5-0.2-0.10.2-0.30.9-0.61.30.7-0.7-0.81.10.7-0.5
Cocaine response after cond. corrected0.50.82.1-1.4-1.3-1.31.1-1.01.0-0.30.30.8-0.40.40.60.5-0.60.5
Cocaine response after cond. not corrected0.60.91.4-1.0-1.0-1.11.2-1.11.1-0.90.8-0.1-0.80.81.1-0.3-1.11.0
Cocaine response before conditioning0.91.14.31.21.10.7-0.30.00.1-1.10.9-2.1-0.80.80.8-1.8-0.80.9
Saline control response2.83.97.52.02.02.7-2.32.3-2.31.7-1.70.42.1-2.1-2.00.62.0-2.0
Bone: connectivity density1.11.84.2-0.5-0.6-0.51.0-1.21.3-2.12.0-1.3-1.61.61.4-0.9-1.31.5
Bone: cortical apparent density0.50.82.4-1.6-1.4-1.41.0-0.70.70.4-0.31.40.0-0.00.31.0-0.3-0.1
Bone: cortical area0.30.41.30.50.30.6-0.50.6-0.61.1-1.00.40.8-0.8-0.50.10.5-0.3
Bone: cortical porosity0.10.10.40.1-0.10.5-0.40.3-0.3-0.40.40.20.2-0.2-0.60.60.5-0.5
Bone: cortical porosity0.20.20.60.30.20.7-0.60.4-0.4-0.40.50.10.2-0.2-0.60.50.6-0.6
Bone: cortical thickness0.61.11.8-1.0-1.0-1.31.4-1.21.2-0.30.4-0.2-0.90.91.3-0.7-1.31.3
Bone: cortical thickness0.10.10.30.20.20.1-0.20.2-0.20.5-0.40.10.3-0.3-0.20.00.2-0.3
Bone: cortical tissue density0.50.82.5-1.6-1.4-1.41.0-0.80.70.3-0.21.4-0.00.00.30.9-0.3-0.1
Condit. Reinf. active minus inactive responses1.71.93.10.91.01.2-1.41.5-1.51.4-1.71.01.6-1.6-1.61.01.5-1.7
Condit. Reinf. active-inactive response ratio3.13.35.11.11.31.9-2.02.0-2.01.3-1.71.32.0-2.0-2.21.52.2-2.3
Condit. Reinf. active responses0.81.11.90.10.30.6-0.80.9-0.91.2-1.31.21.1-1.1-1.21.21.2-1.4
Condit. Reinf. inactive responses0.30.30.9-0.8-0.8-0.90.8-0.70.70.10.20.2-0.50.50.50.0-0.60.4
Incentive salience index mean0.91.22.30.40.60.8-1.01.1-1.11.3-1.41.01.2-1.2-1.21.01.2-1.5
Condit. Reinf. lever presses0.00.00.1-0.10.10.00.0-0.00.00.2-0.1-0.1-0.10.10.1-0.0-0.1-0.2
Condit. Reinf. active minus inactive responses5.17.813.83.63.63.7-3.53.4-3.32.5-2.6-0.62.6-2.6-2.4-0.52.4-2.3
Condit. Reinf. active-inactive response ratio0.50.82.11.31.41.5-1.21.1-1.00.5-0.6-0.70.7-0.7-0.6-0.60.5-0.5
Condit. Reinf. active responses8.211.818.84.24.14.3-4.24.1-4.13.4-3.4-0.43.2-3.2-3.1-0.23.1-2.9
Condit. Reinf. inactive responses4.66.89.52.92.82.9-3.03.1-3.13.1-2.90.22.5-2.5-2.50.32.5-2.4
Condit. Reinf. lever presses8.412.225.85.15.04.6-4.34.2-4.13.2-3.2-1.92.7-2.7-2.4-1.72.4-2.3
Condit. Reinf. lever reinforcers received8.612.020.14.34.34.5-4.34.2-4.13.4-3.4-0.63.2-3.2-3.1-0.43.0-2.9
Conditioned reinforcement - actives0.00.10.40.40.50.6-0.20.1-0.1-0.50.3-0.3-0.10.10.1-0.3-0.10.2
Conditioned reinforcement - inactives0.20.41.8-1.0-1.0-0.30.3-0.20.2-0.0-0.01.30.2-0.2-0.51.30.5-0.5
Conditioned locomotion0.61.04.00.70.70.30.0-0.30.3-1.11.1-2.0-1.11.10.8-1.4-0.90.9
Patch foraging indifference point 0 sec0.51.54.91.82.21.9-1.41.3-1.30.8-0.7-1.10.8-0.8-0.4-1.10.5-0.8
Patch foraging indifference point AUC0.20.51.20.60.90.4-0.80.8-0.81.1-0.90.20.6-0.6-0.70.10.7-1.0
Delay disc. indifference point, 0s delay0.60.72.01.01.11.0-0.90.9-0.91.4-0.8-0.30.6-0.6-0.6-0.30.7-0.5
Delay disc. indifference point, 16s delay0.50.72.8-0.6-0.50.5-0.20.3-0.30.3-0.01.50.8-0.8-0.91.70.8-1.0
Delay disc. indifference point, 2s delay0.91.01.80.80.81.3-1.11.1-1.11.2-0.80.41.0-1.0-1.10.71.2-1.2
Delay disc. indifference point, 24s delay0.40.72.7-1.4-1.4-0.80.7-0.50.50.1-0.11.60.3-0.3-0.21.50.1-0.2
Delay disc. indifference point, 4s delay1.71.83.31.21.21.4-1.41.5-1.51.8-1.50.51.4-1.4-1.30.51.4-1.4
Delay disc. indifference point, 8s delay0.10.10.4-0.6-0.6-0.20.3-0.30.3-0.30.40.6-0.10.1-0.00.6-0.1-0.1
Indifference point function ln k0.10.20.70.40.20.5-0.0-0.10.2-0.80.7-0.8-0.30.30.4-0.6-0.30.5
Indifference point function log k0.10.20.70.40.20.5-0.0-0.10.2-0.80.7-0.8-0.30.30.4-0.6-0.30.5
Patch foraging total patch changes 0 sec0.41.24.31.62.11.6-1.21.1-1.10.8-0.6-1.10.7-0.7-0.2-1.20.3-0.6
Patch foraging total patch changes 12 sec1.11.53.31.11.51.0-1.31.4-1.41.8-1.60.21.2-1.2-1.10.11.1-1.3
Patch foraging total patch changes 18 sec0.41.02.41.31.51.4-1.21.2-1.21.0-0.8-0.30.8-0.8-0.6-0.40.8-1.0
Patch foraging total patch changes 24 sec0.51.62.51.21.61.3-1.31.4-1.41.5-1.30.21.4-1.4-1.20.01.2-1.1
Patch foraging total patch changes 6 sec0.30.52.60.81.60.5-0.70.6-0.60.4-0.3-0.80.1-0.1-0.1-0.80.0-0.7
Patch foraging time to switch 0 sec0.72.77.6-2.5-2.7-2.11.9-1.91.8-1.41.31.3-1.11.10.81.3-0.71.0
Patch foraging water rate 0 sec0.52.06.22.22.51.7-1.71.6-1.61.0-0.9-1.10.9-0.9-0.8-1.00.8-0.9
Patch foraging water rate 12 sec0.41.57.21.31.4-0.00.0-0.00.1-0.0-0.1-2.3-0.70.71.3-2.7-1.21.3
Patch foraging water rate 18 sec0.71.54.52.12.01.1-1.21.2-1.11.0-1.1-1.50.7-0.7-0.1-1.80.00.1
Patch foraging water rate 24 sec0.50.72.50.40.4-0.30.4-0.40.5-0.50.4-1.3-0.60.61.1-1.6-1.21.0
Patch foraging water rate 6 sec0.40.63.00.70.70.20.1-0.10.2-0.10.1-1.4-0.30.30.9-1.7-0.91.0
Seeking ratio, delayed vs. immediate footshock1.52.13.4-1.8-1.8-1.01.8-1.81.8-1.81.80.2-1.21.21.20.0-1.11.4
Distance traveled before self-admin0.40.82.8-0.6-0.7-1.71.1-1.00.9-0.10.2-0.6-0.70.70.9-0.8-1.01.3
Distance traveled after self-admin1.11.93.7-0.4-0.5-1.51.2-1.31.3-1.11.2-1.8-1.41.41.6-1.6-1.61.9
Extensor digitorum longus weight0.10.20.6-0.5-0.7-0.80.6-0.40.40.5-0.40.50.0-0.00.3-0.0-0.40.5
Bone: elastic displacement2.33.04.0-1.7-1.6-1.92.0-2.02.0-1.81.8-0.5-1.91.91.8-0.5-1.81.7
Bone: elastic work4.55.97.6-2.1-2.1-2.62.6-2.72.7-2.72.7-1.1-2.82.82.6-1.0-2.52.5
Bone: endosteal estimation1.74.16.81.91.62.6-2.32.3-2.31.8-1.80.92.3-2.3-2.31.02.2-1.9
Bone: endosteal perimeter1.63.96.52.22.02.5-2.42.3-2.31.8-1.80.32.1-2.1-2.00.52.1-1.8
Epididymis fat weight0.10.72.0-1.2-1.0-1.41.1-1.00.9-0.40.10.5-0.50.51.0-0.1-0.90.7
Delta time in closed arm before/after self-admin0.50.41.3-1.1-0.9-0.90.7-0.40.40.5-0.51.10.4-0.4-0.10.90.10.0
Delta time in open arm before/after self-admin2.12.55.42.01.82.3-2.11.9-1.91.0-1.00.11.5-1.5-1.60.21.5-1.4
Diff in mean of infusions in LGA sessions0.71.26.3-1.7-1.8-0.30.5-0.40.4-0.10.41.80.1-0.1-0.82.50.8-0.9
Delay discount exponential model param0.10.20.80.70.60.1-0.30.2-0.2-0.1-0.3-0.8-0.10.10.2-0.9-0.20.3
Extinction: sum of active levers before priming0.10.20.50.3-0.20.2-0.40.4-0.40.5-0.7-0.00.4-0.4-0.40.20.5-0.4
Active lever presses in extinction session 61.11.14.60.50.6-0.20.2-0.40.4-0.91.0-2.1-1.41.40.8-1.5-0.90.9
Bone: final force0.50.83.0-0.5-0.70.4-0.20.3-0.40.8-0.51.71.0-1.0-1.01.61.0-0.9
Bone: final moment0.50.72.2-0.3-0.50.5-0.30.4-0.50.8-0.61.51.0-1.0-1.01.41.0-0.8
Food consumed during 24 hour testing period0.61.33.92.01.91.8-1.31.0-0.9-0.20.3-1.80.1-0.1-0.2-1.30.1-0.2
Glucose0.20.31.40.0-0.1-0.20.5-0.50.5-1.20.5-0.6-0.40.40.7-0.8-0.70.7
Heart weight0.60.92.01.31.41.3-1.41.2-1.20.1-0.3-0.40.5-0.5-0.90.10.9-0.9
Delay discount hyperbolic model param0.10.20.90.50.5-0.1-0.10.0-0.0-0.3-0.1-0.8-0.30.30.4-0.9-0.30.4
Intermittent access intake day 1-15 change0.42.15.30.20.3-0.60.9-1.01.0-0.80.9-2.3-1.51.51.9-2.3-1.81.9
Intermittent access intake escalation0.31.75.30.60.6-0.20.5-0.70.7-0.91.1-2.3-1.41.41.7-2.2-1.51.6
Intermittent access intake escalation 20.20.41.10.2-0.0-0.20.3-0.40.4-0.40.5-1.0-0.60.60.9-1.0-0.70.9
Intermitt. access day 1 inactive lever presses0.11.13.8-1.9-1.9-1.21.1-0.90.90.0-0.11.5-0.10.1-0.11.50.1-0.1
Intermitt. access day 15 inactive lever presses0.10.40.7-0.8-0.9-0.50.6-0.60.6-0.70.70.4-0.60.60.50.3-0.30.4
Intermitt. access escalation Index0.00.10.20.10.10.4-0.30.3-0.20.0-0.20.40.4-0.4-0.10.30.3-0.4
Intermittent access day 1 total infusions0.41.12.71.31.31.6-1.41.2-1.20.3-0.40.11.0-1.0-0.90.21.0-0.9
Intermittent access day 15 total infusions0.20.41.21.11.01.1-0.70.5-0.5-0.20.2-0.80.0-0.00.2-0.80.00.2
Intermittent access terminal intake (last 3 days)0.30.61.71.31.11.3-1.00.9-0.80.2-0.2-0.60.4-0.4-0.2-0.50.3-0.3
Intermittent access total infusions0.60.71.81.31.21.3-1.00.9-0.90.4-0.4-0.60.6-0.6-0.3-0.50.5-0.3
Intermittent access day 1 locomotion0.20.41.50.20.21.2-0.60.5-0.5-0.30.20.60.5-0.5-0.70.80.7-0.7
Intermittent access day 15 total locomotion0.20.71.50.10.30.30.3-0.50.6-1.21.2-1.1-1.11.10.9-1.0-0.80.9
Intermittent access total locomotion0.20.31.30.80.71.2-0.60.5-0.5-0.20.2-0.50.2-0.2-0.2-0.30.2-0.1
Intermittent access standard deviation0.10.51.2-0.10.0-0.70.7-0.50.50.7-0.3-0.7-0.40.41.0-1.1-0.91.0
Left kidney weight0.10.72.90.71.00.1-0.30.6-0.61.7-1.50.00.9-0.90.1-0.90.1-0.1
Right kidney weight0.21.74.61.11.30.8-1.01.3-1.32.1-2.10.61.8-1.8-0.7-0.20.9-0.8
Cocaine induced anxiety0.61.54.9-2.2-2.2-1.41.3-1.21.2-0.90.71.5-0.50.50.11.7-0.10.0
Post-drug Anxiety0.80.94.4-1.2-1.1-0.30.1-0.0-0.0-0.1-0.11.70.4-0.4-1.02.11.0-1.1
Baseline Anxiety1.62.64.21.82.02.0-2.02.0-1.91.2-1.30.31.5-1.5-1.60.41.6-1.8
Tail length2.312.316.63.13.03.7-4.04.1-4.13.5-3.91.53.8-3.8-3.91.63.7-3.7
Length with tail2.611.416.02.72.73.6-3.63.7-3.73.6-3.91.84.0-4.0-3.61.63.4-3.5
Length without tail0.10.72.20.10.21.2-0.50.6-0.60.8-0.81.01.5-1.5-0.60.60.6-0.8
Times rat made contact with spout0.20.20.7-0.4-0.40.40.10.0-0.00.4-0.30.90.6-0.6-0.30.70.3-0.3
Lifetime Intake0.70.92.51.61.51.5-1.21.1-1.00.4-0.4-0.80.6-0.6-0.3-0.70.5-0.3
Liver weight, left0.50.82.4-0.4-0.60.4-0.20.3-0.31.0-0.81.61.3-1.3-0.81.20.9-0.6
Liver weight, right0.91.64.5-0.3-0.30.2-0.40.7-0.72.1-1.52.01.6-1.6-1.11.41.2-1.1
Locomotor activity0.20.31.10.91.00.2-0.40.4-0.40.6-0.7-0.80.1-0.10.1-1.0-0.20.1
Locomotor testing distance0.61.53.41.81.81.3-1.31.3-1.31.5-1.6-0.61.1-1.1-0.6-1.00.5-0.5
Locomotor testing rearing0.51.74.21.31.21.3-1.31.4-1.41.8-2.00.41.5-1.5-1.0-0.01.1-0.9
Locomotion in novel chamber1.41.93.3-1.0-1.0-1.41.5-1.61.6-1.21.4-0.7-1.41.41.8-0.9-1.81.4
Locomotion in novel chamber post-restriction0.10.41.00.90.61.0-0.50.3-0.2-0.60.7-1.0-0.30.30.3-0.9-0.30.3
Fecal boli incidents, locomotor time 10.41.22.7-1.5-1.5-0.91.0-1.11.1-1.31.60.2-1.21.20.31.0-0.30.5
Change in fecal boli incidents, locomotor task0.30.30.90.60.80.6-0.50.6-0.60.2-0.80.30.9-0.9-0.3-0.20.2-0.5
Time >=10cm from walls, locomotor time 10.50.61.11.01.01.1-1.10.9-0.90.1-0.20.00.7-0.7-0.80.20.6-1.1
Bouts of movement, locomotor time 10.50.61.40.20.20.9-0.70.6-0.60.3-0.10.90.7-0.7-1.21.11.1-0.9
Total resting periods, locomotor time 10.10.10.6-0.2-0.20.4-0.10.00.0-0.20.50.70.1-0.1-0.50.80.5-0.3
Rest time, locomotor task time 10.10.20.70.00.20.6-0.40.2-0.2-0.90.60.60.4-0.4-0.50.70.5-0.4
Distance moved, locomotor task time 10.00.10.5-0.0-0.2-0.40.3-0.10.10.7-0.6-0.20.1-0.10.3-0.5-0.40.4
Vertical activity count, locomotor time 10.00.21.6-0.0-0.20.10.00.2-0.21.3-1.00.40.5-0.5-0.30.20.2-0.2
Time >=10cm from walls, locomotor time 21.64.56.22.12.12.5-2.52.5-2.51.7-2.10.92.4-2.4-2.20.72.0-2.3
Bouts of movement, locomotor time 21.03.35.00.70.31.2-1.51.7-1.72.1-1.92.22.1-2.1-2.22.02.2-1.9
Total resting periods, locomotor time 20.52.14.60.2-0.20.8-1.01.1-1.21.7-1.52.11.7-1.7-1.81.91.8-1.5
Rest time, locomotor task time 20.91.63.2-1.7-1.8-1.71.5-1.51.5-1.11.20.6-1.01.00.90.5-0.91.0
Distance moved, locomotor task time 21.51.93.41.81.81.8-1.61.6-1.61.4-1.5-0.31.4-1.4-1.0-0.50.9-1.0
Vertical activity count, locomotor time 20.61.42.60.80.71.1-1.11.2-1.21.6-1.50.91.3-1.3-1.40.71.3-1.2
Light reinforcement 10.83.67.9-2.0-1.9-2.82.4-2.22.2-1.21.4-0.2-1.91.92.0-0.6-2.02.0
Light reinforcement 21.94.46.7-0.4-0.4-2.01.8-1.91.9-1.81.9-2.4-2.52.52.6-2.5-2.62.6
Bone: marrow area1.53.75.91.71.42.4-2.12.1-2.11.7-1.71.02.2-2.2-2.21.02.2-1.8
Bone: maximum diameter1.63.35.22.11.92.3-2.22.1-2.11.8-1.80.11.9-1.9-1.70.21.8-1.5
Bone: maximum force0.20.31.1-0.3-0.60.4-0.10.2-0.20.3-0.11.10.6-0.6-0.61.00.6-0.4
Bone: maximum moment0.10.20.6-0.0-0.40.5-0.20.2-0.20.4-0.20.70.5-0.5-0.50.70.5-0.2
Mean time between licks in bursts1.69.613.12.72.82.9-3.53.6-3.63.6-3.51.23.3-3.3-3.21.13.3-3.3
Mean num. licks in bursts0.82.15.02.12.22.2-1.81.7-1.60.7-0.9-1.01.0-1.0-0.9-0.80.9-1.0
Cd content in liver0.40.51.3-0.2-0.20.4-0.40.4-0.40.5-0.61.10.7-0.7-0.91.10.9-0.7
Co content in liver2.93.44.31.61.62.0-2.02.1-2.11.8-1.80.92.1-2.1-1.90.92.1-2.0
Cu content in liver1.72.02.71.01.01.5-1.41.5-1.51.5-1.60.91.6-1.6-1.61.01.6-1.6
Fe content in liver0.00.00.1-0.2-0.20.20.0-0.00.00.1-0.00.30.1-0.1-0.10.30.1-0.2
K content in liver0.20.20.7-0.6-0.6-0.60.5-0.30.20.8-0.70.70.2-0.20.10.3-0.10.0
Mg content in liver0.20.20.60.00.1-0.40.4-0.30.30.2-0.2-0.5-0.40.40.7-0.8-0.60.4
Mn content in liver2.42.73.5-1.5-1.6-1.71.8-1.91.9-1.71.8-0.6-1.71.71.7-0.6-1.71.8
Na content in liver0.30.31.30.90.80.8-0.40.3-0.3-0.00.1-1.1-0.10.10.2-1.0-0.20.3
Rb content in liver0.40.51.70.30.31.3-0.70.6-0.60.1-0.20.40.7-0.7-0.80.70.8-0.9
Se content in liver3.33.98.7-2.8-3.0-2.12.4-2.42.4-1.91.90.8-1.61.61.40.8-1.51.6
Sr content in liver1.51.33.50.40.4-0.60.5-0.60.6-1.11.1-1.9-1.41.41.3-1.7-1.31.2
Zn content in liver1.01.23.51.71.90.9-1.21.2-1.21.2-1.2-1.00.6-0.6-0.4-1.10.4-0.5
Bone: minimum diameter1.73.35.91.21.01.7-1.71.9-1.92.4-2.31.42.2-2.2-1.91.11.9-1.7
Time in familiar zone, hab. session 10.10.10.40.60.40.4-0.40.4-0.40.4-0.6-0.20.3-0.3-0.3-0.30.30.0
Time in novel zone, hab. session 10.20.20.7-0.6-0.4-0.10.1-0.00.0-0.1-0.00.90.3-0.3-0.30.90.3-0.5
Total zone transitions, hab. session 10.30.41.40.40.20.20.0-0.20.3-0.80.8-1.2-0.70.70.5-0.9-0.60.8
Total locomotion distance, hab. session 10.81.22.8-0.1-0.00.0-0.50.8-0.81.7-1.71.51.3-1.3-1.11.01.0-1.2
Locomotion velocity, hab. session 10.50.72.7-0.1-0.1-0.3-0.30.5-0.61.6-1.41.21.0-1.0-0.80.80.7-0.9
Time in familiar zone, hab. session 22.83.14.62.01.91.8-2.12.1-2.11.6-1.70.21.8-1.8-1.90.31.9-1.7
Time in novel zone, hab. session 22.93.14.8-1.4-1.3-1.92.0-2.02.0-1.41.4-0.9-1.91.92.2-1.1-2.22.1
Total zone transitions, hab. session 20.81.13.61.81.81.0-1.00.8-0.80.1-0.1-1.9-0.20.20.1-1.6-0.20.2
Total locomotion distance, hab. session 21.72.27.31.01.00.5-1.11.5-1.52.7-2.60.91.8-1.8-1.30.31.2-1.3
Locomotion velocity, hab. session 21.72.37.80.90.80.5-1.11.5-1.52.8-2.61.11.8-1.8-1.30.41.3-1.3
Novel to familiar place preference ratio1.62.13.70.20.41.3-1.21.3-1.31.4-1.51.71.7-1.7-1.61.71.7-1.9
Novelty place preference1.52.03.30.30.41.2-1.21.3-1.31.5-1.51.61.7-1.7-1.61.51.6-1.8
Time in novel zone, NPP test1.92.33.80.50.61.3-1.31.4-1.51.6-1.61.51.8-1.8-1.71.51.8-2.0
Total zone transitions, NPP test1.11.73.60.00.1-0.80.9-1.01.0-0.91.3-1.9-1.61.61.6-1.8-1.71.7
Total locomotion distance, NPP test0.40.52.2-0.5-0.3-1.50.8-0.50.41.2-0.80.1-0.20.20.7-0.6-0.80.5
Locomotion velocity, NPP test0.50.83.2-0.8-0.7-1.81.2-0.80.81.0-0.60.1-0.50.51.0-0.6-1.00.8
Intraocular pressure0.81.35.2-0.3-0.3-0.20.6-0.90.9-2.32.3-1.2-1.31.30.9-0.6-0.80.7
Delta distance traveled before/after self-admin0.70.82.91.31.21.7-1.21.0-1.0-0.0-0.0-0.60.5-0.5-0.6-0.20.7-0.7
Delta ambulatory time before/after self-admin0.30.52.01.11.11.4-1.00.8-0.7-0.30.3-0.70.2-0.2-0.3-0.30.4-0.5
Parametrial fat weight1.53.55.8-1.1-1.3-1.92.0-2.02.0-1.21.7-1.4-1.91.92.3-1.8-2.42.4
Pavlov. Cond. lever latency0.70.92.0-1.0-0.9-1.41.2-1.11.1-0.70.7-0.1-0.90.91.0-0.4-1.01.1
Pavlov. Cond. magazine entry latency1.82.45.52.32.12.0-1.91.9-1.81.3-1.4-1.01.2-1.2-1.0-0.80.9-1.0
Pavlov. Cond. change in total contacts1.82.03.91.31.22.0-1.71.6-1.60.9-1.10.41.4-1.4-1.60.81.6-1.6
Pavlov. Cond. index score1.51.83.61.91.71.9-1.81.7-1.61.0-1.1-0.51.1-1.1-1.1-0.31.1-1.2
Pavlov. Cond. latency score1.41.83.61.71.61.9-1.71.7-1.61.0-1.1-0.31.2-1.2-1.2-0.01.2-1.3
Pavlov. Cond. lever contacts0.60.81.71.21.01.3-1.21.1-1.10.6-0.7-0.20.8-0.8-0.80.00.8-0.9
Pavlov. Cond. magazine entry number1.92.55.2-2.2-2.1-2.32.0-1.91.9-1.11.30.7-1.31.31.20.4-1.21.2
Pavlov. Cond. intertrial magazine entries0.30.41.2-1.1-0.9-0.60.7-0.70.7-0.40.40.7-0.30.30.10.7-0.10.1
Pavlov. Cond. lever-magazine prob. diff.1.21.53.21.71.61.8-1.61.5-1.50.8-0.9-0.51.0-1.0-1.0-0.21.0-1.1
Pavlov. Cond. response bias0.81.02.41.51.41.3-1.31.2-1.20.7-0.8-0.70.7-0.7-0.6-0.50.6-0.6
Pavlov. Cond. lever latency8.211.629.3-5.4-5.3-4.24.2-4.03.9-2.82.92.9-2.12.11.72.8-1.71.6
Pavlov. Cond. magazine entry latency1.52.29.32.22.10.4-0.70.6-0.60.5-0.5-2.9-0.60.61.0-3.1-0.91.0
Pavlov. Cond. change in total contacts4.110.026.15.15.03.8-3.83.6-3.52.6-2.7-2.91.9-1.9-1.5-2.81.5-1.5
Pavlov. Cond. index score4.77.420.24.54.43.0-3.23.0-2.92.3-2.3-2.91.3-1.3-0.9-2.91.0-0.9
Pavlov. Cond. latency score3.86.017.44.24.12.6-2.82.6-2.62.0-2.0-3.01.0-1.0-0.6-3.00.7-0.5
Pavlov. Cond. lever contacts7.611.227.15.25.24.2-4.13.9-3.92.9-3.0-2.62.2-2.2-1.8-2.41.8-1.8
Pavlov. Cond. magazine entry number2.53.29.8-3.1-3.1-1.41.7-1.51.4-0.90.93.10.1-0.1-0.33.00.2-0.3
Pavlov. Cond. intertrial magazine entries1.12.53.80.60.71.4-1.41.5-1.51.5-1.61.61.8-1.8-1.91.61.9-2.0
Pavlov. Cond. lever-magazine prob. diff.4.77.319.64.44.42.9-3.23.0-3.02.3-2.4-2.81.4-1.4-1.0-2.81.0-1.0
Pavlov. Cond. response bias7.510.327.35.25.23.8-3.83.7-3.62.7-2.7-3.21.7-1.7-1.3-3.01.4-1.3
Time in closed arm before self-admin0.50.93.01.71.61.1-1.11.0-0.90.3-0.3-1.20.2-0.2-0.1-1.30.1-0.3
Time in closed arm after self-admin0.30.30.8-0.8-0.8-0.90.7-0.60.6-0.40.60.3-0.40.40.30.4-0.30.3
Time in open arm before self-admin3.74.58.1-2.8-2.8-2.72.7-2.62.6-1.81.70.5-2.02.01.80.3-1.91.8
Time in open arm after self-admin0.10.20.30.30.30.6-0.50.4-0.40.2-0.30.40.4-0.4-0.50.30.4-0.4
Bone: periosteal estimation0.92.03.51.41.01.9-1.51.6-1.61.6-1.40.61.7-1.7-1.50.51.5-1.1
Bone: periosteal perimeter0.81.52.41.61.31.5-1.41.5-1.41.4-1.3-0.11.2-1.2-1.0-0.11.0-0.8
Bone: post-yield work0.10.20.30.50.20.5-0.50.5-0.50.5-0.40.10.5-0.5-0.4-0.00.3-0.2
Progressive ratio test 1 active lever presses0.10.10.50.10.20.6-0.1-0.00.0-0.70.7-0.2-0.20.20.10.10.10.1
Progressive ratio test 1 breakpoint0.10.10.50.10.20.6-0.20.0-0.0-0.70.7-0.2-0.10.10.00.10.10.0
Progressive ratio test 1 inactive lever presses0.10.20.5-0.7-0.70.10.4-0.50.5-0.70.50.6-0.10.10.10.5-0.10.3
Progressive ratio test 2 active lever presses0.10.21.00.50.41.0-0.60.5-0.50.00.00.00.4-0.4-0.30.10.5-0.3
Progressive ratio test 2 breakpoint0.20.21.10.60.51.0-0.60.5-0.5-0.00.0-0.00.4-0.4-0.30.00.4-0.3
Progressive ratio test 2 inactive lever presses0.00.10.20.10.00.00.1-0.20.2-0.40.3-0.4-0.30.30.5-0.4-0.30.4
Incentive Sensitization - Responses0.10.30.80.70.50.9-0.70.7-0.70.5-0.50.10.7-0.7-0.4-0.00.6-0.4
Incentive Sensitization - Breakpoint0.10.20.50.70.40.7-0.50.5-0.50.4-0.4-0.10.4-0.4-0.1-0.30.3-0.2
Sum of active levers in priming session hrs 5-60.20.10.90.40.5-0.3-0.00.0-0.00.1-0.2-0.9-0.20.20.2-0.6-0.30.3
Progressive ratio0.31.02.80.40.4-0.30.4-0.50.6-0.90.9-1.7-1.01.01.1-1.6-1.21.2
Food seeking constrained by brief footshock1.31.73.11.71.61.2-1.61.6-1.61.7-1.5-0.21.0-1.0-0.9-0.40.9-1.1
Seeking ratio, punishment vs. effort1.12.45.21.11.01.1-1.51.7-1.72.3-2.11.11.7-1.7-1.50.81.6-1.7
Retroperitoneal fat weight0.41.84.0-2.0-2.0-1.81.7-1.21.11.5-1.21.90.4-0.40.90.4-0.80.8
Reaction time number correct0.10.20.4-0.10.1-0.50.4-0.40.4-0.50.3-0.6-0.60.60.6-0.6-0.60.5
Reaction time mean minus median0.10.71.30.70.70.8-0.91.0-1.01.1-1.10.30.9-0.9-0.90.20.8-0.8
Reaction time mean minus median AUC0.10.50.80.70.70.8-0.80.8-0.80.9-0.90.10.8-0.8-0.70.00.6-0.6
Reaction time num false alarms0.71.14.3-1.7-1.8-1.01.0-0.80.70.3-0.02.10.3-0.3-0.11.70.2-0.3
Reaction time num false alarms AUC0.41.03.3-1.7-1.8-1.11.1-0.90.80.00.31.70.0-0.00.11.4-0.0-0.0
Reaction time trials correct on left0.10.20.4-0.10.1-0.50.4-0.40.4-0.50.3-0.6-0.60.60.6-0.6-0.60.5
Reaction time trials on left0.10.30.5-0.20.1-0.50.5-0.50.5-0.50.4-0.6-0.70.70.7-0.7-0.60.6
Reaction time mean0.51.24.7-1.3-1.6-0.80.4-0.10.10.9-0.92.20.7-0.7-0.81.90.7-0.6
Reaction time mean AUC0.51.24.5-1.4-1.8-0.80.5-0.30.20.6-0.72.10.6-0.6-0.71.90.6-0.5
Median of all reaction times0.91.45.3-1.7-2.1-1.20.8-0.60.50.6-0.62.30.4-0.4-0.52.00.5-0.3
Reaction time omissions0.20.30.7-0.8-0.7-0.30.6-0.40.40.5-0.50.80.4-0.40.40.2-0.30.2
Reaction time false alarm rate0.71.03.5-1.6-1.9-1.11.0-0.80.80.20.11.80.2-0.20.01.40.0-0.0
Reaction time premature initiation rate1.52.43.61.81.71.4-1.81.9-1.91.8-1.70.11.5-1.5-1.50.21.5-1.5
Reaction time premature initiations0.31.01.81.31.30.8-1.21.2-1.21.2-1.1-0.30.8-0.8-0.8-0.30.8-0.8
Std. dev. reaction times0.61.93.10.1-0.10.8-0.91.1-1.21.7-1.61.81.7-1.7-1.71.61.6-1.5
Reaction time trials completed0.10.30.5-0.20.1-0.50.5-0.50.5-0.50.4-0.6-0.70.70.7-0.7-0.60.6
Reaction time trials AUC0.00.10.3-0.10.1-0.50.3-0.30.3-0.20.1-0.4-0.50.50.5-0.5-0.40.4
Run reversals in cocaine runway, females0.80.93.30.70.90.1-0.70.9-0.91.8-1.80.21.1-1.1-0.6-0.10.6-0.8
Run reversals in cocaine runway, males0.30.30.8-0.8-0.6-0.30.6-0.60.6-0.90.90.2-0.40.40.30.5-0.30.4
Latency to leave start box in cocaine runway0.40.62.2-1.3-1.5-1.00.7-0.70.6-0.30.30.5-0.50.5-0.01.20.1-0.2
Latency to leave start box in cocaine runway, F0.60.83.5-1.1-1.1-0.50.10.0-0.10.4-0.61.30.4-0.4-0.91.91.0-1.1
Latency to leave start box in cocaine runway, M1.31.32.0-0.8-1.1-1.21.1-1.21.2-1.11.2-0.8-1.41.41.2-0.5-1.21.2
Std. dev. time between licks in bursts2.03.86.91.31.21.3-1.92.1-2.12.6-2.31.32.1-2.1-2.21.22.3-2.1
Total sessions with >9 infusions1.11.43.71.91.91.8-1.51.4-1.40.6-0.7-0.70.9-0.9-0.6-0.70.7-0.6
Short access day 1 total inactive lever presses0.20.41.2-0.2-0.20.5-0.40.4-0.40.3-0.11.00.4-0.4-0.81.10.8-0.7
Short access day 10 total inactive lever presses0.10.93.0-1.7-1.7-1.01.1-0.90.9-0.40.31.5-0.20.20.21.1-0.10.0
Short access day 1 total infusions1.63.15.02.22.22.2-2.22.1-2.11.6-1.50.21.7-1.7-1.50.11.6-1.5
Short access day 10 total infusions0.71.13.11.61.61.8-1.31.2-1.10.5-0.6-0.70.8-0.8-0.5-0.70.5-0.4
Short access total infusions1.11.64.11.91.92.0-1.71.5-1.50.6-0.5-0.71.0-1.0-0.7-0.50.8-0.7
Short access day 1 locomotion0.30.41.50.91.01.2-0.50.3-0.2-0.80.7-1.0-0.20.20.2-0.7-0.10.2
Short access day 10 total locomotion0.10.30.90.70.90.8-0.30.3-0.30.6-0.5-0.70.1-0.10.3-0.9-0.30.2
Short access total locomotion0.20.31.00.30.30.60.0-0.20.2-0.70.7-1.0-0.50.50.4-0.6-0.40.5
One hour access (0.3 mA shock)0.20.30.90.70.90.6-0.20.2-0.1-0.10.2-0.9-0.00.00.3-0.9-0.30.3
Compulsive drug intake1.52.34.1-1.5-1.2-1.41.7-1.81.8-2.02.00.1-1.51.51.4-0.5-1.51.4
One hour access (shock baseline)0.40.93.21.61.51.0-0.90.9-0.90.9-0.7-1.80.2-0.20.0-1.20.10.0
Social response proportion0.30.31.7-0.8-0.4-1.30.8-0.60.50.5-0.30.4-0.40.40.60.1-0.50.1
Social responses0.60.83.1-0.5-0.3-0.40.00.3-0.31.8-1.41.60.9-0.9-0.50.90.5-0.8
Social time1.01.63.5-1.7-1.9-1.61.6-1.51.5-0.70.90.5-1.21.21.10.3-1.11.0
Soleus weight0.31.03.1-0.6-0.4-0.4-0.00.4-0.41.8-1.51.71.0-1.0-0.71.20.7-0.9
Bone: stiffness0.81.55.2-0.7-0.80.4-0.40.5-0.61.0-0.72.31.3-1.3-1.42.31.4-1.4
Tibialis anterior weight0.20.81.80.30.20.6-0.60.8-0.81.3-1.21.01.2-1.2-0.90.70.9-0.7
Time to tail flick, vehicle, before self-admin0.20.31.40.80.90.6-0.20.2-0.1-0.0-0.1-0.50.1-0.10.6-1.2-0.30.5
Time to tail flick, vehicle, after self-admin0.40.92.51.10.91.6-1.41.1-1.10.1-0.00.10.7-0.7-1.20.51.1-0.8
Time to tail flick, test, before self-admin2.62.95.91.92.12.4-2.12.0-2.00.9-1.40.51.7-1.7-1.70.41.8-1.8
Time to tail flick, test, after self-admin2.93.04.41.31.21.4-1.91.9-2.01.7-1.81.02.1-2.1-2.01.22.0-2.1
Delta time to tail flick, vehicle, before/after SA0.20.21.0-0.1-0.10.4-0.50.3-0.3-0.20.30.30.1-0.1-0.91.00.7-0.7
Delta time to tail flick, test, before/after SA0.60.72.7-1.1-1.3-1.61.1-1.00.90.00.30.2-0.40.40.70.1-0.80.7
Tibia length0.30.92.91.31.21.7-1.21.1-1.00.4-0.3-0.50.7-0.7-0.8-0.20.9-0.7
Ambulatory time before self-admin0.30.82.3-0.7-1.0-1.51.1-1.01.0-0.40.5-0.4-0.80.80.9-0.6-1.01.3
Ambulatory time after self-admin0.60.93.30.3-0.0-0.50.4-0.50.6-0.91.0-1.8-1.01.00.9-1.3-0.91.3
Bone: tissue strength2.93.14.5-0.9-0.9-1.61.7-1.81.8-1.91.8-1.4-2.12.12.0-1.4-2.02.1
Total heroin consumption0.20.20.90.50.4-0.30.10.0-0.10.6-0.6-0.7-0.00.00.4-0.9-0.40.4
Bone: trabecular number1.12.03.6-1.4-1.5-1.01.5-1.61.6-1.91.9-0.4-1.51.51.3-0.2-1.31.4
Bone: trabecular spacing0.40.62.50.70.9-0.40.1-0.10.1-0.10.2-1.6-0.80.80.9-1.5-0.90.4
Bone: trabecular thickness1.11.53.7-0.2-0.30.8-0.80.8-0.91.0-1.11.91.5-1.5-1.51.81.5-1.4
Bone: trabecular tissue density1.83.211.0-1.0-1.10.1-0.40.7-0.82.0-1.83.32.0-2.0-1.92.91.9-1.8
Water consumed over 24 hours0.10.20.7-0.6-0.6-0.20.5-0.60.6-0.60.90.1-0.30.30.30.2-0.40.3
Number of responses in last shaping day0.81.03.8-0.8-0.80.3-0.20.3-0.40.7-0.41.81.0-1.0-1.12.01.2-1.1