Hub : Genes

Folr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Folr2 0.06 0.04 7.0e-05 0.03 0.02 0.02 0.02 4.4e-04 1.7e-03 4.2e-03 1.1e-03
2 PL gene expression Folr2 0.06 0.04 3.4e-04 0.03 0.03 0.02 0.02 5.0e-04 8.4e-04 2.5e-03 2.0e-03
3 BLA gene expression Folr2 0.13 0.09 5.1e-04 0.05 0.06 0.07 0.06 1.1e-03 3.7e-04 1.2e-04 3.1e-04
4 Liver gene expression Folr2 0.35 0.14 0.0e+00 0.16 0.22 0.21 0.22 6.6e-17 7.1e-24 2.4e-23 1.2e-23
5 Adipose alternative TSS XM_039106129.2 0.06 0.04 6.4e-05 0.02 0.02 0.02 0.02 2.2e-03 1.5e-03 2.2e-03 2.0e-03
6 NAcc gene expression Folr2 0.04 0.03 3.5e-05 0.02 0.03 0.03 0.03 3.8e-04 8.2e-06 5.6e-05 7.9e-05
7 Brain gene expression Folr2 0.04 0.04 2.7e-03 0.03 0.02 0.02 0.02 8.4e-04 3.5e-03 2.8e-03 3.9e-03
8 Adipose intron excision ratio chr1_165613053_165616147 0.04 0.03 1.2e-03 0.02 0.02 0.01 0.02 2.7e-03 2.8e-03 9.3e-03 4.3e-03
9 Adipose alternative TSS XM_006229858.4 0.06 0.04 1.1e-04 0.01 0.02 0.02 0.02 9.7e-03 3.7e-03 2.8e-03 4.3e-03
10 Adipose alternative TSS XM_006229858.4 0.2 0.11 5.6e-17 0.12 0.12 0.11 0.12 9.2e-14 2.8e-13 4.6e-12 2.8e-13
11 Adipose alternative TSS XM_039106129.2 0.19 0.11 1.7e-16 0.12 0.12 0.11 0.12 2.2e-13 5.2e-13 5.8e-12 7.5e-13
12 Liver isoform ratio XM_006229858.4 0.04 0.03 3.7e-04 0.02 0.01 0.02 0.01 2.1e-03 1.2e-02 5.7e-03 1.0e-02
13 Adipose mRNA stability Folr2 0.23 0.14 0.0e+00 0.11 0.13 0.12 0.12 3.6e-12 3.8e-14 8.9e-13 2.3e-13
14 IL gene expression Folr2 0.19 0.12 5.7e-03 0.06 0.04 0 0.02 1.4e-02 4.5e-02 3.2e-01 1.0e-01
15 Adipose isoform ratio XM_006229858.4 0.29 0.13 0.0e+00 0.21 0.21 0.2 0.21 3.9e-23 2.0e-22 3.5e-22 1.1e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.41.40.60.60.10.5-0.60.61.1-1.20.00.6-0.6-0.40.30.4-0.3
Area under the delay curve0.20.21.20.60.6-0.10.1-0.10.1-0.2-0.2-1.0-0.30.30.41.1-0.30.4
BMI with tail0.82.97.10.40.32.31.9-1.41.4-1.30.61.11.1-1.1-2.5-2.72.4-2.3
BMI without tail0.51.56.5-1.5-1.50.3-0.10.4-0.4-1.81.71.5-0.00.0-0.9-2.60.9-0.9
Body weight0.41.98.2-1.1-1.2-0.4-0.71.1-1.1-2.92.7-0.5-1.71.70.3-0.8-0.40.4
Weight adjusted by age0.30.51.5-0.9-1.2-0.8-0.80.8-0.8-0.40.7-0.1-0.60.60.6-0.3-0.70.4
Bone surface0.61.13.7-1.0-1.0-1.9-1.31.1-1.1-0.30.3-0.2-1.01.01.00.5-1.11.0
Bone volume0.30.61.9-0.7-0.5-1.4-0.90.8-0.8-0.40.3-0.4-0.80.80.90.6-0.90.8
Breakpoint value in progressive ratio session0.70.81.91.01.21.41.1-1.01.00.4-0.50.20.9-0.9-0.8-0.20.9-1.0
Number of licking bursts1.32.15.72.32.42.01.9-1.71.60.6-0.9-1.30.8-0.8-0.81.00.8-0.9
Context. condit. distance diff. score1.31.54.9-2.2-2.2-1.4-1.51.3-1.2-0.30.71.7-0.40.40.2-1.5-0.30.0
Locomotion velocity, session 12.32.43.60.80.91.71.5-1.61.61.5-1.81.31.9-1.9-1.7-1.21.8-1.9
Locomotion distance, session 10.70.93.5-0.7-0.60.20.2-0.30.30.5-0.71.91.0-1.0-1.0-1.71.0-1.0
Locomotion velocity, session 20.60.72.1-0.20.00.70.6-0.60.6-0.0-0.11.20.9-0.9-1.0-1.41.1-1.3
Locomotion distance, session 20.60.93.2-0.4-0.30.80.5-0.50.5-0.20.01.61.0-1.0-1.1-1.81.2-1.3
Locomotion velocity, session 30.30.31.1-1.0-0.6-0.8-0.80.6-0.60.10.00.8-0.00.00.4-0.4-0.40.2
Locomotion distance, session 30.40.41.7-1.0-0.7-1.0-0.60.4-0.30.8-0.61.30.4-0.40.0-0.7-0.0-0.2
Stereotopy head waving bouts, day 30.40.51.20.3-0.0-0.1-0.30.4-0.5-1.00.9-1.1-0.80.80.70.9-0.70.9
Stereotopy head waving duration, day 30.10.10.6-0.4-0.8-0.1-0.20.2-0.2-0.1-0.10.60.1-0.1-0.1-0.50.10.2
Locomotion velocity, session 70.70.81.50.30.41.10.8-0.90.90.7-0.50.81.1-1.1-1.1-1.01.1-1.2
Locomotion distance, session 70.10.10.30.50.60.50.4-0.30.3-0.20.2-0.40.1-0.1-0.10.30.1-0.3
Stereotopy head waving bouts, day 71.61.85.2-2.2-2.3-2.3-1.81.5-1.4-0.00.21.4-0.50.50.7-1.0-0.80.7
Stereotopy head waving duration, day 71.41.75.3-2.2-2.3-2.0-1.61.4-1.3-0.10.31.5-0.40.40.5-1.2-0.60.6
Locomotion velocity, session 80.70.92.4-1.6-1.2-1.3-1.21.1-1.1-0.70.80.8-0.60.60.7-0.6-0.60.1
Locomotion distance, session 81.01.54.6-2.1-1.9-0.8-1.01.0-0.9-0.80.92.1-0.00.0-0.3-2.10.3-0.5
Degree of sensitization distance1.11.24.10.40.30.3-0.10.5-0.6-2.01.8-1.7-1.31.30.81.0-0.80.8
Degree of sensitization stereotypy2.93.28.7-3.0-2.9-2.8-2.32.0-1.9-0.30.51.8-0.80.81.0-1.3-1.10.8
Conditioned locomotion0.40.51.60.50.50.2-0.10.2-0.3-0.90.6-1.3-0.70.70.81.1-0.70.5
Cocaine response after cond. corrected0.60.82.11.41.31.31.1-1.01.00.3-0.3-0.80.4-0.4-0.60.50.6-0.5
Cocaine response after cond. not corrected0.80.91.41.01.01.11.2-1.11.10.9-0.80.10.8-0.8-1.1-0.31.1-1.0
Cocaine response before conditioning0.91.14.3-1.2-1.1-0.7-0.30.00.11.1-0.92.10.8-0.8-0.8-1.80.8-0.9
Saline control response2.93.97.5-2.0-2.0-2.7-2.32.3-2.3-1.71.7-0.4-2.12.12.00.6-2.02.0
Bone: connectivity density1.11.84.20.50.60.51.0-1.21.32.1-2.01.31.6-1.6-1.4-0.91.3-1.5
Bone: cortical apparent density0.60.82.41.61.41.41.0-0.70.7-0.40.3-1.4-0.00.0-0.31.00.30.1
Bone: cortical area0.30.41.3-0.5-0.3-0.6-0.50.6-0.6-1.11.0-0.4-0.80.80.50.1-0.50.3
Bone: cortical porosity0.10.10.4-0.10.1-0.5-0.40.3-0.30.4-0.4-0.2-0.20.20.60.6-0.50.5
Bone: cortical porosity0.20.20.6-0.3-0.2-0.7-0.60.4-0.40.4-0.5-0.1-0.20.20.60.5-0.60.6
Bone: cortical thickness0.61.11.81.01.01.31.4-1.21.20.3-0.40.20.9-0.9-1.3-0.71.3-1.3
Bone: cortical thickness0.10.10.3-0.2-0.2-0.1-0.20.2-0.2-0.50.4-0.1-0.30.30.20.0-0.20.3
Bone: cortical tissue density0.60.82.51.61.41.41.0-0.80.7-0.30.2-1.40.0-0.0-0.30.90.30.1
Condit. Reinf. active minus inactive responses1.71.93.1-0.9-1.0-1.2-1.41.5-1.5-1.41.7-1.0-1.61.61.61.0-1.51.7
Condit. Reinf. active-inactive response ratio3.13.35.1-1.1-1.3-1.9-2.02.0-2.0-1.31.7-1.3-2.02.02.21.5-2.22.3
Condit. Reinf. active responses0.91.11.9-0.1-0.3-0.6-0.80.9-0.9-1.21.3-1.2-1.11.11.21.2-1.21.4
Condit. Reinf. inactive responses0.30.30.90.80.80.90.8-0.70.7-0.1-0.2-0.20.5-0.5-0.50.00.6-0.4
Incentive salience index mean1.01.22.3-0.4-0.6-0.8-1.01.1-1.1-1.31.4-1.0-1.21.21.21.0-1.21.5
Condit. Reinf. lever presses0.00.00.10.1-0.1-0.00.0-0.00.0-0.20.10.10.1-0.1-0.1-0.00.10.2
Condit. Reinf. active minus inactive responses6.07.813.8-3.6-3.6-3.7-3.53.4-3.3-2.52.60.6-2.62.62.4-0.5-2.42.3
Condit. Reinf. active-inactive response ratio0.70.82.1-1.3-1.4-1.5-1.21.1-1.0-0.50.60.7-0.70.70.6-0.6-0.50.5
Condit. Reinf. active responses8.511.818.8-4.2-4.1-4.3-4.24.1-4.1-3.43.40.4-3.23.23.1-0.2-3.12.9
Condit. Reinf. inactive responses5.26.89.5-2.9-2.8-2.9-3.03.1-3.1-3.12.9-0.2-2.52.52.50.3-2.52.4
Condit. Reinf. lever presses8.812.225.8-5.1-5.0-4.6-4.34.2-4.1-3.23.21.9-2.72.72.4-1.7-2.42.3
Condit. Reinf. lever reinforcers received8.612.020.1-4.3-4.3-4.5-4.34.2-4.1-3.43.40.6-3.23.23.1-0.4-3.02.9
Conditioned reinforcement - actives0.10.10.4-0.4-0.5-0.6-0.20.1-0.10.5-0.30.30.1-0.1-0.1-0.30.1-0.2
Conditioned reinforcement - inactives0.30.41.81.01.00.30.3-0.20.20.00.0-1.3-0.20.20.51.3-0.50.5
Conditioned locomotion0.71.04.0-0.7-0.7-0.30.0-0.30.31.1-1.12.01.1-1.1-0.8-1.40.9-0.9
Patch foraging indifference point 0 sec0.81.54.9-1.8-2.2-1.9-1.41.3-1.3-0.80.71.1-0.80.80.4-1.1-0.50.8
Patch foraging indifference point AUC0.40.51.2-0.6-0.9-0.4-0.80.8-0.8-1.10.9-0.2-0.60.60.70.1-0.71.0
Delay disc. indifference point, 0s delay0.60.72.0-1.0-1.1-1.0-0.90.9-0.9-1.40.80.3-0.60.60.6-0.3-0.70.5
Delay disc. indifference point, 16s delay0.60.72.80.60.5-0.5-0.20.3-0.3-0.30.0-1.5-0.80.80.91.7-0.81.0
Delay disc. indifference point, 2s delay0.91.01.8-0.8-0.8-1.3-1.11.1-1.1-1.20.8-0.4-1.01.01.10.7-1.21.2
Delay disc. indifference point, 24s delay0.60.72.71.41.40.80.7-0.50.5-0.10.1-1.6-0.30.30.21.5-0.10.2
Delay disc. indifference point, 4s delay1.71.83.3-1.2-1.2-1.4-1.41.5-1.5-1.81.5-0.5-1.41.41.30.5-1.41.4
Delay disc. indifference point, 8s delay0.10.10.40.60.60.20.3-0.30.30.3-0.4-0.60.1-0.10.00.60.10.1
Indifference point function ln k0.10.20.7-0.4-0.2-0.5-0.0-0.10.20.8-0.70.80.3-0.3-0.4-0.60.3-0.5
Indifference point function log k0.10.20.7-0.4-0.2-0.5-0.0-0.10.20.8-0.70.80.3-0.3-0.4-0.60.3-0.5
Patch foraging total patch changes 0 sec0.61.24.3-1.6-2.1-1.6-1.21.1-1.1-0.80.61.1-0.70.70.2-1.2-0.30.6
Patch foraging total patch changes 12 sec1.21.53.3-1.1-1.5-1.0-1.31.4-1.4-1.81.6-0.2-1.21.21.10.1-1.11.3
Patch foraging total patch changes 18 sec0.71.02.4-1.3-1.5-1.4-1.21.2-1.2-1.00.80.3-0.80.80.6-0.4-0.81.0
Patch foraging total patch changes 24 sec0.91.62.5-1.2-1.6-1.3-1.31.4-1.4-1.51.3-0.2-1.41.41.20.0-1.21.1
Patch foraging total patch changes 6 sec0.30.52.6-0.8-1.6-0.5-0.70.6-0.6-0.40.30.8-0.10.10.1-0.8-0.00.7
Patch foraging time to switch 0 sec1.32.77.62.52.72.11.9-1.91.81.4-1.3-1.31.1-1.1-0.81.30.7-1.0
Patch foraging water rate 0 sec1.02.06.2-2.2-2.5-1.7-1.71.6-1.6-1.00.91.1-0.90.90.8-1.0-0.80.9
Patch foraging water rate 12 sec0.71.57.2-1.3-1.40.00.0-0.00.10.00.12.30.7-0.7-1.3-2.71.2-1.3
Patch foraging water rate 18 sec1.01.54.5-2.1-2.0-1.1-1.21.2-1.1-1.01.11.5-0.70.70.1-1.8-0.0-0.1
Patch foraging water rate 24 sec0.50.72.5-0.4-0.40.30.4-0.40.50.5-0.41.30.6-0.6-1.1-1.61.2-1.0
Patch foraging water rate 6 sec0.40.63.0-0.7-0.7-0.20.1-0.10.20.1-0.11.40.3-0.3-0.9-1.70.9-1.0
Seeking ratio, delayed vs. immediate footshock1.72.13.41.81.81.01.8-1.81.81.8-1.8-0.21.2-1.2-1.20.01.1-1.4
Distance traveled before self-admin0.60.82.80.60.71.71.1-1.00.90.1-0.20.60.7-0.7-0.9-0.81.0-1.3
Distance traveled after self-admin1.61.93.70.40.51.51.2-1.31.31.1-1.21.81.4-1.4-1.6-1.61.6-1.9
Extensor digitorum longus weight0.10.20.60.50.70.80.6-0.40.4-0.50.4-0.5-0.00.0-0.3-0.00.4-0.5
Bone: elastic displacement2.63.04.01.71.61.92.0-2.02.01.8-1.80.51.9-1.9-1.8-0.51.8-1.7
Bone: elastic work4.55.97.62.12.12.62.6-2.72.72.7-2.71.12.8-2.8-2.6-1.02.5-2.5
Bone: endosteal estimation1.94.16.8-1.9-1.6-2.6-2.32.3-2.3-1.81.8-0.9-2.32.32.31.0-2.21.9
Bone: endosteal perimeter1.83.96.5-2.2-2.0-2.5-2.42.3-2.3-1.81.8-0.3-2.12.12.00.5-2.11.8
Epididymis fat weight0.20.72.01.21.01.41.1-1.00.90.4-0.1-0.50.5-0.5-1.0-0.10.9-0.7
Delta time in closed arm before/after self-admin0.50.41.31.10.90.90.7-0.40.4-0.50.5-1.1-0.40.40.10.9-0.1-0.0
Delta time in open arm before/after self-admin2.62.55.4-2.0-1.8-2.3-2.11.9-1.9-1.01.0-0.1-1.51.51.60.2-1.51.4
Diff in mean of infusions in LGA sessions1.01.26.31.71.80.30.5-0.40.40.1-0.4-1.8-0.10.10.82.5-0.80.9
Delay discount exponential model param0.20.20.8-0.7-0.6-0.1-0.30.2-0.20.10.30.80.1-0.1-0.2-0.90.2-0.3
Extinction: sum of active levers before priming0.10.20.5-0.30.2-0.2-0.40.4-0.4-0.50.70.0-0.40.40.40.2-0.50.4
Active lever presses in extinction session 61.11.14.6-0.5-0.60.20.2-0.40.40.9-1.02.11.4-1.4-0.8-1.50.9-0.9
Bone: final force0.50.83.00.50.7-0.4-0.20.3-0.4-0.80.5-1.7-1.01.01.01.6-1.00.9
Bone: final moment0.50.72.20.30.5-0.5-0.30.4-0.5-0.80.6-1.5-1.01.01.01.4-1.00.8
Food consumed during 24 hour testing period0.91.33.9-2.0-1.9-1.8-1.31.0-0.90.2-0.31.8-0.10.10.2-1.3-0.10.2
Glucose0.20.31.4-0.00.10.20.5-0.50.51.2-0.50.60.4-0.4-0.7-0.80.7-0.7
Heart weight0.60.92.0-1.3-1.4-1.3-1.41.2-1.2-0.10.30.4-0.50.50.90.1-0.90.9
Delay discount hyperbolic model param0.20.20.9-0.5-0.50.1-0.10.0-0.00.30.10.80.3-0.3-0.4-0.90.3-0.4
Intermittent access intake day 1-15 change1.02.15.3-0.2-0.30.60.9-1.01.00.8-0.92.31.5-1.5-1.9-2.31.8-1.9
Intermittent access intake escalation0.81.75.3-0.6-0.60.20.5-0.70.70.9-1.12.31.4-1.4-1.7-2.21.5-1.6
Intermittent access intake escalation 20.30.41.1-0.20.00.20.3-0.40.40.4-0.51.00.6-0.6-0.9-1.00.7-0.9
Intermitt. access day 1 inactive lever presses0.31.13.81.91.91.21.1-0.90.9-0.00.1-1.50.1-0.10.11.5-0.10.1
Intermitt. access day 15 inactive lever presses0.20.40.70.80.90.50.6-0.60.60.7-0.7-0.40.6-0.6-0.50.30.3-0.4
Intermitt. access escalation Index0.10.10.2-0.1-0.1-0.4-0.30.3-0.2-0.00.2-0.4-0.40.40.10.3-0.30.4
Intermittent access day 1 total infusions0.71.12.7-1.3-1.3-1.6-1.41.2-1.2-0.30.4-0.1-1.01.00.90.2-1.00.9
Intermittent access day 15 total infusions0.30.41.2-1.1-1.0-1.1-0.70.5-0.50.2-0.20.8-0.00.0-0.2-0.8-0.0-0.2
Intermittent access terminal intake (last 3 days)0.40.61.7-1.3-1.1-1.3-1.00.9-0.8-0.20.20.6-0.40.40.2-0.5-0.30.3
Intermittent access total infusions0.60.71.8-1.3-1.2-1.3-1.00.9-0.9-0.40.40.6-0.60.60.3-0.5-0.50.3
Intermittent access day 1 locomotion0.30.41.5-0.2-0.2-1.2-0.60.5-0.50.3-0.2-0.6-0.50.50.70.8-0.70.7
Intermittent access day 15 total locomotion0.40.71.5-0.1-0.3-0.30.3-0.50.61.2-1.21.11.1-1.1-0.9-1.00.8-0.9
Intermittent access total locomotion0.20.31.3-0.8-0.7-1.2-0.60.5-0.50.2-0.20.5-0.20.20.2-0.3-0.20.1
Intermittent access standard deviation0.20.51.20.1-0.00.70.7-0.50.5-0.70.30.70.4-0.4-1.0-1.10.9-1.0
Left kidney weight0.10.72.9-0.7-1.0-0.1-0.30.6-0.6-1.71.5-0.0-0.90.9-0.1-0.9-0.10.1
Right kidney weight0.41.74.6-1.1-1.3-0.8-1.01.3-1.3-2.12.1-0.6-1.81.80.7-0.2-0.90.8
Cocaine induced anxiety1.11.54.92.22.21.41.3-1.21.20.9-0.7-1.50.5-0.5-0.11.70.1-0.0
Post-drug Anxiety0.90.94.41.21.10.30.1-0.0-0.00.10.1-1.7-0.40.41.02.1-1.01.1
Baseline Anxiety2.32.64.2-1.8-2.0-2.0-2.02.0-1.9-1.21.3-0.3-1.51.51.60.4-1.61.8
Tail length3.212.316.6-3.1-3.0-3.7-4.04.1-4.1-3.53.9-1.5-3.83.83.91.6-3.73.7
Length with tail2.611.416.0-2.7-2.7-3.6-3.63.7-3.7-3.63.9-1.8-4.04.03.61.6-3.43.5
Length without tail0.20.72.2-0.1-0.2-1.2-0.50.6-0.6-0.80.8-1.0-1.51.50.60.6-0.60.8
Times rat made contact with spout0.20.20.70.40.4-0.40.10.0-0.0-0.40.3-0.9-0.60.60.30.7-0.30.3
Lifetime Intake0.70.92.5-1.6-1.5-1.5-1.21.1-1.0-0.40.40.8-0.60.60.3-0.7-0.50.3
Liver weight, left0.50.82.40.40.6-0.4-0.20.3-0.3-1.00.8-1.6-1.31.30.81.2-0.90.6
Liver weight, right0.91.64.50.30.3-0.2-0.40.7-0.7-2.11.5-2.0-1.61.61.11.4-1.21.1
Locomotor activity0.20.31.1-0.9-1.0-0.2-0.40.4-0.4-0.60.70.8-0.10.1-0.1-1.00.2-0.1
Locomotor testing distance0.81.53.4-1.8-1.8-1.3-1.31.3-1.3-1.51.60.6-1.11.10.6-1.0-0.50.5
Locomotor testing rearing0.91.74.2-1.3-1.2-1.3-1.31.4-1.4-1.82.0-0.4-1.51.51.0-0.0-1.10.9
Locomotion in novel chamber1.51.93.31.01.01.41.5-1.61.61.2-1.40.71.4-1.4-1.8-0.91.8-1.4
Locomotion in novel chamber post-restriction0.20.41.0-0.9-0.6-1.0-0.50.3-0.20.6-0.71.00.3-0.3-0.3-0.90.3-0.3
Fecal boli incidents, locomotor time 10.81.22.71.51.50.91.0-1.11.11.3-1.6-0.21.2-1.2-0.31.00.3-0.5
Change in fecal boli incidents, locomotor task0.40.30.9-0.6-0.8-0.6-0.50.6-0.6-0.20.8-0.3-0.90.90.3-0.2-0.20.5
Time >=10cm from walls, locomotor time 10.60.61.1-1.0-1.0-1.1-1.10.9-0.9-0.10.2-0.0-0.70.70.80.2-0.61.1
Bouts of movement, locomotor time 10.50.61.4-0.2-0.2-0.9-0.70.6-0.6-0.30.1-0.9-0.70.71.21.1-1.10.9
Total resting periods, locomotor time 10.10.10.60.20.2-0.4-0.10.00.00.2-0.5-0.7-0.10.10.50.8-0.50.3
Rest time, locomotor task time 10.20.20.7-0.0-0.2-0.6-0.40.2-0.20.9-0.6-0.6-0.40.40.50.7-0.50.4
Distance moved, locomotor task time 10.10.10.50.00.20.40.3-0.10.1-0.70.60.2-0.10.1-0.3-0.50.4-0.4
Vertical activity count, locomotor time 10.10.21.60.00.2-0.10.00.2-0.2-1.31.0-0.4-0.50.50.30.2-0.20.2
Time >=10cm from walls, locomotor time 23.04.56.2-2.1-2.1-2.5-2.52.5-2.5-1.72.1-0.9-2.42.42.20.7-2.02.3
Bouts of movement, locomotor time 22.13.35.0-0.7-0.3-1.2-1.51.7-1.7-2.11.9-2.2-2.12.12.22.0-2.21.9
Total resting periods, locomotor time 21.22.14.6-0.20.2-0.8-1.01.1-1.2-1.71.5-2.1-1.71.71.81.9-1.81.5
Rest time, locomotor task time 21.21.63.21.71.81.71.5-1.51.51.1-1.2-0.61.0-1.0-0.90.50.9-1.0
Distance moved, locomotor task time 21.61.93.4-1.8-1.8-1.8-1.61.6-1.6-1.41.50.3-1.41.41.0-0.5-0.91.0
Vertical activity count, locomotor time 21.01.42.6-0.8-0.7-1.1-1.11.2-1.2-1.61.5-0.9-1.31.31.40.7-1.31.2
Light reinforcement 11.53.67.92.01.92.82.4-2.22.21.2-1.40.21.9-1.9-2.0-0.62.0-2.0
Light reinforcement 22.84.46.70.40.42.01.8-1.91.91.8-1.92.42.5-2.5-2.6-2.52.6-2.6
Bone: marrow area1.73.75.9-1.7-1.4-2.4-2.12.1-2.1-1.71.7-1.0-2.22.22.21.0-2.21.8
Bone: maximum diameter1.83.35.2-2.1-1.9-2.3-2.22.1-2.1-1.81.8-0.1-1.91.91.70.2-1.81.5
Bone: maximum force0.20.31.10.30.6-0.4-0.10.2-0.2-0.30.1-1.1-0.60.60.61.0-0.60.4
Bone: maximum moment0.10.20.60.00.4-0.5-0.20.2-0.2-0.40.2-0.7-0.50.50.50.7-0.50.2
Mean time between licks in bursts3.99.613.1-2.7-2.8-2.9-3.53.6-3.6-3.63.5-1.2-3.33.33.21.1-3.33.3
Mean num. licks in bursts1.32.15.0-2.1-2.2-2.2-1.81.7-1.6-0.70.91.0-1.01.00.9-0.8-0.91.0
Cd content in liver0.40.51.30.20.2-0.4-0.40.4-0.4-0.50.6-1.1-0.70.70.91.1-0.90.7
Co content in liver2.93.44.3-1.6-1.6-2.0-2.02.1-2.1-1.81.8-0.9-2.12.11.90.9-2.12.0
Cu content in liver1.72.02.7-1.0-1.0-1.5-1.41.5-1.5-1.51.6-0.9-1.61.61.61.0-1.61.6
Fe content in liver0.00.00.10.20.2-0.20.0-0.00.0-0.10.0-0.3-0.10.10.10.3-0.10.2
K content in liver0.20.20.70.60.60.60.5-0.30.2-0.80.7-0.7-0.20.2-0.10.30.1-0.0
Mg content in liver0.20.20.6-0.0-0.10.40.4-0.30.3-0.20.20.50.4-0.4-0.7-0.80.6-0.4
Mn content in liver2.42.73.51.51.61.71.8-1.91.91.7-1.80.61.7-1.7-1.7-0.61.7-1.8
Na content in liver0.30.31.3-0.9-0.8-0.8-0.40.3-0.30.0-0.11.10.1-0.1-0.2-1.00.2-0.3
Rb content in liver0.40.51.7-0.3-0.3-1.3-0.70.6-0.6-0.10.2-0.4-0.70.70.80.7-0.80.9
Se content in liver3.33.98.72.83.02.12.4-2.42.41.9-1.9-0.81.6-1.6-1.40.81.5-1.6
Sr content in liver1.51.33.5-0.4-0.40.60.5-0.60.61.1-1.11.91.4-1.4-1.3-1.71.3-1.2
Zn content in liver1.11.23.5-1.7-1.9-0.9-1.21.2-1.2-1.21.21.0-0.60.60.4-1.1-0.40.5
Bone: minimum diameter1.83.35.9-1.2-1.0-1.7-1.71.9-1.9-2.42.3-1.4-2.22.21.91.1-1.91.7
Time in familiar zone, hab. session 10.20.10.4-0.6-0.4-0.4-0.40.4-0.4-0.40.60.2-0.30.30.3-0.3-0.3-0.0
Time in novel zone, hab. session 10.20.20.70.60.40.10.1-0.00.00.10.0-0.9-0.30.30.30.9-0.30.5
Total zone transitions, hab. session 10.30.41.4-0.4-0.2-0.20.0-0.20.30.8-0.81.20.7-0.7-0.5-0.90.6-0.8
Total locomotion distance, hab. session 10.81.22.80.10.0-0.0-0.50.8-0.8-1.71.7-1.5-1.31.31.11.0-1.01.2
Locomotion velocity, hab. session 10.50.72.70.10.10.3-0.30.5-0.6-1.61.4-1.2-1.01.00.80.8-0.70.9
Time in familiar zone, hab. session 23.03.14.6-2.0-1.9-1.8-2.12.1-2.1-1.61.7-0.2-1.81.81.90.3-1.91.7
Time in novel zone, hab. session 23.13.14.81.41.31.92.0-2.02.01.4-1.40.91.9-1.9-2.2-1.12.2-2.1
Total zone transitions, hab. session 20.81.13.6-1.8-1.8-1.0-1.00.8-0.8-0.10.11.90.2-0.2-0.1-1.60.2-0.2
Total locomotion distance, hab. session 21.72.27.3-1.0-1.0-0.5-1.11.5-1.5-2.72.6-0.9-1.81.81.30.3-1.21.3
Locomotion velocity, hab. session 21.72.37.8-0.9-0.8-0.5-1.11.5-1.5-2.82.6-1.1-1.81.81.30.4-1.31.3
Novel to familiar place preference ratio1.92.13.7-0.2-0.4-1.3-1.21.3-1.3-1.41.5-1.7-1.71.71.61.7-1.71.9
Novelty place preference1.82.03.3-0.3-0.4-1.2-1.21.3-1.3-1.51.5-1.6-1.71.71.61.5-1.61.8
Time in novel zone, NPP test2.22.33.8-0.5-0.6-1.3-1.31.4-1.5-1.61.6-1.5-1.81.81.71.5-1.82.0
Total zone transitions, NPP test1.21.73.6-0.0-0.10.80.9-1.01.00.9-1.31.91.6-1.6-1.6-1.81.7-1.7
Total locomotion distance, NPP test0.40.52.20.50.31.50.8-0.50.4-1.20.8-0.10.2-0.2-0.7-0.60.8-0.5
Locomotion velocity, NPP test0.50.83.20.80.71.81.2-0.80.8-1.00.6-0.10.5-0.5-1.0-0.61.0-0.8
Intraocular pressure0.91.35.20.30.30.20.6-0.90.92.3-2.31.21.3-1.3-0.9-0.60.8-0.7
Delta distance traveled before/after self-admin0.70.82.9-1.3-1.2-1.7-1.21.0-1.00.00.00.6-0.50.50.6-0.2-0.70.7
Delta ambulatory time before/after self-admin0.40.52.0-1.1-1.1-1.4-1.00.8-0.70.3-0.30.7-0.20.20.3-0.3-0.40.5
Parametrial fat weight1.53.55.81.11.31.92.0-2.02.01.2-1.71.41.9-1.9-2.3-1.82.4-2.4
Pavlov. Cond. lever latency0.70.92.01.00.91.41.2-1.11.10.7-0.70.10.9-0.9-1.0-0.41.0-1.1
Pavlov. Cond. magazine entry latency1.82.45.5-2.3-2.1-2.0-1.91.9-1.8-1.31.41.0-1.21.21.0-0.8-0.91.0
Pavlov. Cond. change in total contacts1.92.03.9-1.3-1.2-2.0-1.71.6-1.6-0.91.1-0.4-1.41.41.60.8-1.61.6
Pavlov. Cond. index score1.51.83.6-1.9-1.7-1.9-1.81.7-1.6-1.01.10.5-1.11.11.1-0.3-1.11.2
Pavlov. Cond. latency score1.41.83.6-1.7-1.6-1.9-1.71.7-1.6-1.01.10.3-1.21.21.2-0.0-1.21.3
Pavlov. Cond. lever contacts0.70.81.7-1.2-1.0-1.3-1.21.1-1.1-0.60.70.2-0.80.80.80.0-0.80.9
Pavlov. Cond. magazine entry number1.92.55.22.22.12.32.0-1.91.91.1-1.3-0.71.3-1.3-1.20.41.2-1.2
Pavlov. Cond. intertrial magazine entries0.30.41.21.10.90.60.7-0.70.70.4-0.4-0.70.3-0.3-0.10.70.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.21.53.2-1.7-1.6-1.8-1.61.5-1.5-0.80.90.5-1.01.01.0-0.2-1.01.1
Pavlov. Cond. response bias0.81.02.4-1.5-1.4-1.3-1.31.2-1.2-0.70.80.7-0.70.70.6-0.5-0.60.6
Pavlov. Cond. lever latency8.511.629.35.45.34.24.2-4.03.92.8-2.9-2.92.1-2.1-1.72.81.7-1.6
Pavlov. Cond. magazine entry latency1.82.29.3-2.2-2.1-0.4-0.70.6-0.6-0.50.52.90.6-0.6-1.0-3.10.9-1.0
Pavlov. Cond. change in total contacts6.210.026.1-5.1-5.0-3.8-3.83.6-3.5-2.62.72.9-1.91.91.5-2.8-1.51.5
Pavlov. Cond. index score5.57.420.2-4.5-4.4-3.0-3.23.0-2.9-2.32.32.9-1.31.30.9-2.9-1.00.9
Pavlov. Cond. latency score4.66.017.4-4.2-4.1-2.6-2.82.6-2.6-2.02.03.0-1.01.00.6-3.0-0.70.5
Pavlov. Cond. lever contacts8.111.227.1-5.2-5.2-4.2-4.13.9-3.9-2.93.02.6-2.22.21.8-2.4-1.81.8
Pavlov. Cond. magazine entry number2.63.29.83.13.11.41.7-1.51.40.9-0.9-3.1-0.10.10.33.0-0.20.3
Pavlov. Cond. intertrial magazine entries1.62.53.8-0.6-0.7-1.4-1.41.5-1.5-1.51.6-1.6-1.81.81.91.6-1.92.0
Pavlov. Cond. lever-magazine prob. diff.5.47.319.6-4.4-4.4-2.9-3.23.0-3.0-2.32.42.8-1.41.41.0-2.8-1.01.0
Pavlov. Cond. response bias7.610.327.3-5.2-5.2-3.8-3.83.7-3.6-2.72.73.2-1.71.71.3-3.0-1.41.3
Time in closed arm before self-admin0.70.93.0-1.7-1.6-1.1-1.11.0-0.9-0.30.31.2-0.20.20.1-1.3-0.10.3
Time in closed arm after self-admin0.30.30.80.80.80.90.7-0.60.60.4-0.6-0.30.4-0.4-0.30.40.3-0.3
Time in open arm before self-admin4.24.58.12.82.82.72.7-2.62.61.8-1.7-0.52.0-2.0-1.80.31.9-1.8
Time in open arm after self-admin0.10.20.3-0.3-0.3-0.6-0.50.4-0.4-0.20.3-0.4-0.40.40.50.3-0.40.4
Bone: periosteal estimation1.02.03.5-1.4-1.0-1.9-1.51.6-1.6-1.61.4-0.6-1.71.71.50.5-1.51.1
Bone: periosteal perimeter0.91.52.4-1.6-1.3-1.5-1.41.5-1.4-1.41.30.1-1.21.21.0-0.1-1.00.8
Bone: post-yield work0.10.20.3-0.5-0.2-0.5-0.50.5-0.5-0.50.4-0.1-0.50.50.4-0.0-0.30.2
Progressive ratio test 1 active lever presses0.10.10.5-0.1-0.2-0.6-0.1-0.00.00.7-0.70.20.2-0.2-0.10.1-0.1-0.1
Progressive ratio test 1 breakpoint0.10.10.5-0.1-0.2-0.6-0.20.0-0.00.7-0.70.20.1-0.1-0.00.1-0.1-0.0
Progressive ratio test 1 inactive lever presses0.10.20.50.70.7-0.10.4-0.50.50.7-0.5-0.60.1-0.1-0.10.50.1-0.3
Progressive ratio test 2 active lever presses0.20.21.0-0.5-0.4-1.0-0.60.5-0.5-0.0-0.0-0.0-0.40.40.30.1-0.50.3
Progressive ratio test 2 breakpoint0.20.21.1-0.6-0.5-1.0-0.60.5-0.50.0-0.00.0-0.40.40.30.0-0.40.3
Progressive ratio test 2 inactive lever presses0.10.10.2-0.1-0.0-0.00.1-0.20.20.4-0.30.40.3-0.3-0.5-0.40.3-0.4
Incentive Sensitization - Responses0.20.30.8-0.7-0.5-0.9-0.70.7-0.7-0.50.5-0.1-0.70.70.4-0.0-0.60.4
Incentive Sensitization - Breakpoint0.10.20.5-0.7-0.4-0.7-0.50.5-0.5-0.40.40.1-0.40.40.1-0.3-0.30.2
Sum of active levers in priming session hrs 5-60.20.10.9-0.4-0.50.3-0.00.0-0.0-0.10.20.90.2-0.2-0.2-0.60.3-0.3
Progressive ratio0.61.02.7-0.4-0.40.30.4-0.50.60.9-0.91.71.0-1.0-1.1-1.61.2-1.2
Food seeking constrained by brief footshock1.41.73.1-1.7-1.6-1.2-1.61.6-1.6-1.71.50.2-1.01.00.9-0.4-0.91.1
Seeking ratio, punishment vs. effort1.72.45.2-1.1-1.0-1.1-1.51.7-1.7-2.32.1-1.1-1.71.71.50.8-1.61.7
Retroperitoneal fat weight0.41.84.02.02.01.81.7-1.21.1-1.51.2-1.9-0.40.4-0.90.40.8-0.8
Reaction time number correct0.10.20.40.1-0.10.50.4-0.40.40.5-0.30.60.6-0.6-0.6-0.60.6-0.5
Reaction time mean minus median0.30.71.3-0.7-0.7-0.8-0.91.0-1.0-1.11.1-0.3-0.90.90.90.2-0.80.8
Reaction time mean minus median AUC0.20.50.8-0.7-0.7-0.8-0.80.8-0.8-0.90.9-0.1-0.80.80.70.0-0.60.6
Reaction time num false alarms0.81.14.31.71.81.01.0-0.80.7-0.30.0-2.1-0.30.30.11.7-0.20.3
Reaction time num false alarms AUC0.61.03.31.71.81.11.1-0.90.8-0.0-0.3-1.7-0.00.0-0.11.40.00.0
Reaction time trials correct on left0.10.20.40.1-0.10.50.4-0.40.40.5-0.30.60.6-0.6-0.6-0.60.6-0.5
Reaction time trials on left0.20.30.50.2-0.10.50.5-0.50.50.5-0.40.60.7-0.7-0.7-0.70.6-0.6
Reaction time mean0.71.24.71.31.60.80.4-0.10.1-0.90.9-2.2-0.70.70.81.9-0.70.6
Reaction time mean AUC0.71.24.51.41.80.80.5-0.30.2-0.60.7-2.1-0.60.60.71.9-0.60.5
Median of all reaction times1.01.45.31.72.11.20.8-0.60.5-0.60.6-2.3-0.40.40.52.0-0.50.3
Reaction time omissions0.20.30.70.80.70.30.6-0.40.4-0.50.5-0.8-0.40.4-0.40.20.3-0.2
Reaction time false alarm rate0.71.03.51.61.91.11.0-0.80.8-0.2-0.1-1.8-0.20.2-0.01.4-0.00.0
Reaction time premature initiation rate1.72.43.6-1.8-1.7-1.4-1.81.9-1.9-1.81.7-0.1-1.51.51.50.2-1.51.5
Reaction time premature initiations0.51.01.8-1.3-1.3-0.8-1.21.2-1.2-1.21.10.3-0.80.80.8-0.3-0.80.8
Std. dev. reaction times1.01.93.1-0.10.1-0.8-0.91.1-1.2-1.71.6-1.8-1.71.71.71.6-1.61.5
Reaction time trials completed0.20.30.50.2-0.10.50.5-0.50.50.5-0.40.60.7-0.7-0.7-0.70.6-0.6
Reaction time trials AUC0.10.10.30.1-0.10.50.3-0.30.30.2-0.10.40.5-0.5-0.5-0.50.4-0.4
Run reversals in cocaine runway, females0.90.93.3-0.7-0.9-0.1-0.70.9-0.9-1.81.8-0.2-1.11.10.6-0.1-0.60.8
Run reversals in cocaine runway, males0.30.30.80.80.60.30.6-0.60.60.9-0.9-0.20.4-0.4-0.30.50.3-0.4
Latency to leave start box in cocaine runway0.50.62.21.31.51.00.7-0.70.60.3-0.3-0.50.5-0.50.01.2-0.10.2
Latency to leave start box in cocaine runway, F0.70.83.51.11.10.50.10.0-0.1-0.40.6-1.3-0.40.40.91.9-1.01.1
Latency to leave start box in cocaine runway, M1.41.32.00.81.11.21.1-1.21.21.1-1.20.81.4-1.4-1.2-0.51.2-1.2
Std. dev. time between licks in bursts2.83.86.9-1.3-1.2-1.3-1.92.1-2.1-2.62.3-1.3-2.12.12.21.2-2.32.1
Total sessions with >9 infusions1.21.43.7-1.9-1.9-1.8-1.51.4-1.4-0.60.70.7-0.90.90.6-0.7-0.70.6
Short access day 1 total inactive lever presses0.30.41.20.20.2-0.5-0.40.4-0.4-0.30.1-1.0-0.40.40.81.1-0.80.7
Short access day 10 total inactive lever presses0.40.93.01.71.71.01.1-0.90.90.4-0.3-1.50.2-0.2-0.21.10.1-0.0
Short access day 1 total infusions2.33.15.0-2.2-2.2-2.2-2.22.1-2.1-1.61.5-0.2-1.71.71.50.1-1.61.5
Short access day 10 total infusions0.91.13.1-1.6-1.6-1.8-1.31.2-1.1-0.50.60.7-0.80.80.5-0.7-0.50.4
Short access total infusions1.21.64.1-1.9-1.9-2.0-1.71.5-1.5-0.60.50.7-1.01.00.7-0.5-0.80.7
Short access day 1 locomotion0.30.41.5-0.9-1.0-1.2-0.50.3-0.20.8-0.71.00.2-0.2-0.2-0.70.1-0.2
Short access day 10 total locomotion0.20.30.9-0.7-0.9-0.8-0.30.3-0.3-0.60.50.7-0.10.1-0.3-0.90.3-0.2
Short access total locomotion0.20.31.0-0.3-0.3-0.60.0-0.20.20.7-0.71.00.5-0.5-0.4-0.60.4-0.5
One hour access (0.3 mA shock)0.20.30.9-0.7-0.9-0.6-0.20.2-0.10.1-0.20.90.0-0.0-0.3-0.90.3-0.3
Compulsive drug intake1.92.34.11.51.21.41.7-1.81.82.0-2.0-0.11.5-1.5-1.4-0.51.5-1.4
One hour access (shock baseline)0.60.93.2-1.6-1.5-1.0-0.90.9-0.9-0.90.71.8-0.20.2-0.0-1.2-0.1-0.0
Social response proportion0.30.31.70.80.41.30.8-0.60.5-0.50.3-0.40.4-0.4-0.60.10.5-0.1
Social responses0.60.83.10.50.30.40.00.3-0.3-1.81.4-1.6-0.90.90.50.9-0.50.8
Social time1.21.63.51.71.91.61.6-1.51.50.7-0.9-0.51.2-1.2-1.10.31.1-1.0
Soleus weight0.31.03.10.60.40.4-0.00.4-0.4-1.81.5-1.7-1.01.00.71.2-0.70.9
Bone: stiffness0.91.55.20.70.8-0.4-0.40.5-0.6-1.00.7-2.3-1.31.31.42.3-1.41.4
Tibialis anterior weight0.20.81.8-0.3-0.2-0.6-0.60.8-0.8-1.31.2-1.0-1.21.20.90.7-0.90.7
Time to tail flick, vehicle, before self-admin0.30.31.4-0.8-0.9-0.6-0.20.2-0.10.00.10.5-0.10.1-0.6-1.20.3-0.5
Time to tail flick, vehicle, after self-admin0.70.92.5-1.1-0.9-1.6-1.41.1-1.1-0.10.0-0.1-0.70.71.20.5-1.10.8
Time to tail flick, test, before self-admin2.82.95.9-1.9-2.1-2.4-2.12.0-2.0-0.91.4-0.5-1.71.71.70.4-1.81.8
Time to tail flick, test, after self-admin2.93.04.4-1.3-1.2-1.4-1.91.9-2.0-1.71.8-1.0-2.12.12.01.2-2.02.1
Delta time to tail flick, vehicle, before/after SA0.30.21.00.10.1-0.4-0.50.3-0.30.2-0.3-0.3-0.10.10.91.0-0.70.7
Delta time to tail flick, test, before/after SA0.70.72.71.11.31.61.1-1.00.9-0.0-0.3-0.20.4-0.4-0.70.10.8-0.7
Tibia length0.30.92.9-1.3-1.2-1.7-1.21.1-1.0-0.40.30.5-0.70.70.8-0.2-0.90.7
Ambulatory time before self-admin0.60.82.30.71.01.51.1-1.01.00.4-0.50.40.8-0.8-0.9-0.61.0-1.3
Ambulatory time after self-admin0.80.93.3-0.30.00.50.4-0.50.60.9-1.01.81.0-1.0-0.9-1.30.9-1.3
Bone: tissue strength3.03.14.50.90.91.61.7-1.81.81.9-1.81.42.1-2.1-2.0-1.42.0-2.1
Total heroin consumption0.20.20.9-0.5-0.40.30.10.0-0.1-0.60.60.70.0-0.0-0.4-0.90.4-0.4
Bone: trabecular number1.22.03.61.41.51.01.5-1.61.61.9-1.90.41.5-1.5-1.3-0.21.3-1.4
Bone: trabecular spacing0.50.62.5-0.7-0.90.40.1-0.10.10.1-0.21.60.8-0.8-0.9-1.50.9-0.4
Bone: trabecular thickness1.21.53.70.20.3-0.8-0.80.8-0.9-1.01.1-1.9-1.51.51.51.8-1.51.4
Bone: trabecular tissue density2.23.211.01.01.1-0.1-0.40.7-0.8-2.01.8-3.3-2.02.01.92.9-1.91.8
Water consumed over 24 hours0.20.20.70.60.60.20.5-0.60.60.6-0.9-0.10.3-0.3-0.30.20.4-0.3
Number of responses in last shaping day0.91.03.80.80.8-0.3-0.20.3-0.4-0.70.4-1.8-1.01.01.12.0-1.21.1