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Intermitt. access day 15 inactive lever presses

Intermittent access day 15 total inactive lever presses

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

6 significantly associated models · 5 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 7.1e-11 0.00477 1.9e-08 -297 Syt5
2 6 24048319 25760913 3 3 3.9e-09 0.00018 1.0e+00 100 Rbks Supt7l AABR07063281.1
3 8 108584253 109479622 1 1 3.9e-08 0.03336 2.3e-03 -105 Apeh

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.2 2 0 0 0.00 1.000 Rbks Syt5
Epididymis fat weight 7.6 2 0 0 0.00 1.000 Rbks AABR07063281.1
Glucose 12.1 1 0 0 0.00 1.000 Syt5
Heart weight 7.0 1 0 0 0.00 1.000 Supt7l
Right kidney weight 2.7 3 0 0 0.00 1.000 Rbks Syt5 AABR07063281.1
Length without tail 3.2 1 0 0 0.00 1.000 Syt5
Liver weight, left 10.2 1 0 0 0.00 1.000 Syt5
Liver weight, right 11.2 1 0 0 0.00 1.000 Syt5
Retroperitoneal fat weight 5.8 2 1 20 0.00 1.000 Rbks AABR07063281.1
Intraocular pressure 7.6 2 0 0 0.00 1.000 Rbks AABR07063281.1
Extensor digitorum longus weight 2.2 1 0 0 0.00 1.000 AABR07063281.1
Tibialis anterior weight 2.4 1 0 0 0.00 1.000 Syt5
Tibia length 7.5 1 0 0 0.00 1.000 Syt5
Std. dev. time between licks in bursts 14.8 2 1 20 0.00 1.000 Syt5 Apeh
Indifference point 0 sec 6.3 1 0 0 0.00 1.000 Syt5
Indifference point function ln k 8.8 1 0 0 0.00 1.000 Syt5
Indifference point function log k 8.8 1 0 0 0.00 1.000 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0.00 1.000 Syt5
Delay discounting total patch changes 18 sec 5.9 1 0 0 0.00 1.000 Apeh
Delay discounting total patch changes 24 sec 10.3 1 0 0 0.00 1.000 Syt5
Delay discounting total patch changes 6 sec 4.9 1 0 0 0.00 1.000 Apeh
Delay discounting time to switch 0 sec 55.9 1 1 20 0.00 1.000 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0.00 1.000 Syt5
Delay discounting water rate 12 sec 22.1 1 1 20 0.00 1.000 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0.00 1.000 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0.00 1.000 Syt5
Locomotor activity 6.6 1 0 0 0.00 1.000 Rbks
Light reinforcement 1 21.6 1 1 20 0.00 1.000 Syt5
Light reinforcement 2 14.1 2 1 20 0.00 1.000 Supt7l Syt5
Reaction time num false alarms AUC 10.6 1 0 0 0.00 1.000 Syt5
Reaction time mean 5.1 1 0 0 0.00 1.000 Syt5
Reaction time mean AUC 6.2 1 0 0 0.00 1.000 Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.000 Syt5
Reaction time omissions 5.3 1 0 0 0.00 1.000 Syt5
Social response proportion 8.0 1 0 0 0.00 1.000 Syt5
Social time 12.3 2 0 0 0.00 1.000 Rbks Syt5
Conditioned locomotion 5.9 1 0 0 0.00 1.000 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0.00 1.000 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0.00 1.000 Syt5
Saline control response 13.2 1 0 0 0.00 1.000 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0.00 1.000 Syt5
Pavlov. Cond. change in total contacts 5.8 1 0 0 0.00 1.000 Syt5
Conditioned reinforcement - actives 13.9 3 0 0 0.00 1.000 Rbks Syt5 AABR07063281.1
Conditioned reinforcement - inactives 15.4 4 1 20 0.94 0.056 Rbks Supt7l Apeh AABR07063281.1
Conditioned locomotion 10.5 3 0 0 0.00 1.000 Rbks Syt5 AABR07063281.1
Intermittent access intake day 1-15 change 14.5 3 1 20 0.00 1.000 Rbks Syt5 Apeh
Intermittent access intake escalation 15.4 2 0 0 0.00 1.000 Rbks Apeh
Intermittent access intake escalation 2 16.1 3 1 20 0.00 1.000 Rbks Supt7l Apeh
Intermitt. access day 1 inactive lever presses 13.2 3 0 0 0.00 1.000 Rbks Supt7l Syt5
Intermitt. access escalation Index 17.2 1 0 0 0.00 1.000 Syt5
Intermittent access day 1 total infusions 6.2 1 0 0 0.00 1.000 AABR07063281.1
Intermittent access day 15 total infusions 8.1 2 0 0 0.00 1.000 Rbks AABR07063281.1
Intermittent access terminal intake (last 3 days) 7.6 2 0 0 0.00 1.000 Rbks AABR07063281.1
Intermittent access standard deviation 21.8 2 1 20 0.00 1.000 Syt5 Apeh
Cocaine induced anxiety 6.4 1 0 0 0.00 1.000 Apeh
Post-drug Anxiety 10.2 1 0 0 0.00 1.000 Syt5
Baseline Anxiety 26.3 1 1 20 0.00 1.000 Syt5
Lifetime Intake 6.3 1 0 0 0.00 1.000 AABR07063281.1
Incentive Sensitization - Responses 8.7 1 0 0 0.00 1.000 Apeh
Incentive Sensitization - Breakpoint 8.7 2 0 0 0.00 1.000 Syt5 Apeh
Progressive ratio test 1 active lever presses 8.7 2 0 0 0.00 1.000 Apeh AABR07063281.1
Progressive ratio test 1 breakpoint 10.2 1 0 0 0.00 1.000 Apeh
Progressive ratio test 1 inactive lever presses 14.0 3 0 0 0.99 0.013 Rbks Apeh AABR07063281.1
Progressive ratio test 2 inactive lever presses 16.9 4 1 20 0.96 0.011 Rbks Supt7l Apeh AABR07063281.1
Total sessions with >9 infusions 8.9 3 0 0 0.00 1.000 Rbks Apeh AABR07063281.1
Short access day 1 total inactive lever presses 12.7 5 1 20 0.99 0.002 Rbks Supt7l Syt5 Apeh AABR07063281.1
Short access day 10 total inactive lever presses 23.9 2 1 20 0.00 1.000 Supt7l Apeh
Short access day 1 total infusions 11.5 2 0 0 0.00 1.000 Rbks AABR07063281.1
Short access total infusions 8.2 1 0 0 0.00 1.000 AABR07063281.1
Short access day 1 locomotion 13.3 1 0 0 0.00 1.000 AABR07063281.1
Short access day 10 total locomotion 8.8 2 0 0 0.00 1.000 Syt5 Apeh
Short access total locomotion 11.8 2 0 0 0.00 1.000 Syt5 Apeh
Compulsive drug intake 7.7 1 0 0 0.00 1.000 Apeh
One hour access (shock baseline) 24.4 1 1 20 0.00 1.000 Syt5
Number of responses in last shaping day 10.9 2 0 0 0.00 1.000 Syt5 Apeh
Locomotion velocity, session 1 61.5 1 1 20 0.00 1.000 Syt5
Locomotion distance, session 1 22.4 1 1 20 0.00 1.000 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0.00 1.000 Syt5
Locomotion distance, session 2 5.4 1 0 0 0.00 1.000 Syt5
Locomotion distance, session 3 8.7 1 0 0 0.00 1.000 Syt5
Locomotion distance, session 7 10.2 1 0 0 0.00 1.000 Syt5
Locomotion velocity, session 8 15.7 1 0 0 0.00 1.000 Syt5
Locomotion distance, session 8 9.2 1 0 0 0.00 1.000 Syt5
Time in familiar zone, hab. session 1 12.8 1 0 0 0.00 1.000 Syt5
Total zone transitions, hab. session 1 25.5 1 1 20 0.00 1.000 Syt5
Total locomotion distance, hab. session 1 19.3 1 1 20 0.00 1.000 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0.00 1.000 Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0.00 1.000 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0.00 1.000 Syt5
Total locomotion distance, hab. session 2 10.7 1 0 0 0.00 1.000 Syt5
Locomotion velocity, hab. session 2 13.6 1 0 0 0.00 1.000 Syt5
Novelty place preference 7.0 1 0 0 0.00 1.000 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0.00 1.000 Apeh
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0.00 1.000 Syt5
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0.00 1.000 Syt5
Pavlov. Cond. response bias 13.4 1 0 0 0.00 1.000 Syt5
Bone: cortical porosity 7.7 1 0 0 0.00 1.000 Syt5
Bone: elastic displacement 7.7 1 0 0 0.00 1.000 Syt5
Bone: elastic work 5.8 1 0 0 0.00 1.000 Syt5
Bone: post-yield work 11.6 1 0 0 0.00 1.000 Syt5
Bone: stiffness 4.5 1 0 0 0.00 1.000 Syt5
Bone: tissue strength 13.1 1 0 0 0.00 1.000 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0.00 1.000 Syt5
Distance traveled before self-admin 57.6 1 1 20 0.00 1.000 Syt5
Distance traveled after self-admin 56.6 1 1 20 0.00 1.000 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0.00 1.000 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0.00 1.000 Syt5
Extinction: sum of active levers before priming 36.5 1 1 20 0.00 1.000 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0.00 1.000 Syt5
Time in closed arm after self-admin 22.3 1 0 0 0.00 1.000 Syt5
Time in open arm after self-admin 17.1 1 0 0 0.00 1.000 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0.00 1.000 Syt5
Time to tail flick, test, before self-admin 57.2 1 1 20 0.00 1.000 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0.00 1.000 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 20 0.00 1.000 Syt5
Ambulatory time before self-admin 23.5 2 1 20 0.00 1.000 Syt5 Apeh
Ambulatory time after self-admin 61.3 1 1 20 0.00 1.000 Syt5
Area under the delay curve 15.3 1 0 0 0.00 1.000 Rbks
Delay disc. indifference point, 0s delay 17.6 3 1 20 0.00 1.000 Rbks Syt5 AABR07063281.1
Delay disc. indifference point, 16s delay 17.2 2 0 0 0.00 1.000 Rbks Syt5
Delay disc. indifference point, 24s delay 13.3 4 0 0 -0.62 0.269 Rbks Supt7l Syt5 AABR07063281.1
Delay disc. indifference point, 8s delay 13.9 1 0 0 0.00 1.000 Rbks
Delay discount exponential model param 15.2 1 0 0 0.00 1.000 Rbks
Delay discount hyperbolic model param 11.0 1 0 0 0.00 1.000 Rbks
Time >=10cm from walls, locomotor time 1 8.1 1 0 0 0.00 1.000 Rbks
Bouts of movement, locomotor time 1 56.9 1 1 20 0.00 1.000 Syt5
Total resting periods, locomotor time 1 37.3 1 1 20 0.00 1.000 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0.00 1.000 Syt5
Rest time, locomotor task time 2 9.1 1 0 0 0.00 1.000 Syt5
Weight adjusted by age 8.3 1 0 0 0.00 1.000 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 20 0.00 1.000 Syt5
Locomotion in novel chamber 12.7 1 0 0 0.00 1.000 Syt5
Progressive ratio 7.6 1 0 0 0.00 1.000 Syt5
Food seeking constrained by brief footshock 71.1 2 1 20 0.00 1.000 Syt5 AABR07063281.1
Seeking ratio, punishment vs. effort 16.5 1 0 0 0.00 1.000 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0.00 1.000 Syt5
Cd content in liver 7.7 1 0 0 0.00 1.000 Syt5
Co content in liver 19.4 1 0 0 0.00 1.000 Syt5
Rb content in liver 6.5 1 0 0 0.00 1.000 Syt5
Sr content in liver 66.7 1 1 20 0.00 1.000 Syt5
Zn content in liver 12.4 1 0 0 0.00 1.000 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.12
Adipose alternative TSS 0 0.000 1.16
Adipose gene expression 0 0.000 1.08
Adipose isoform ratio 0 0.000 1.11
Adipose intron excision ratio 1 0.034 1.09
Adipose mRNA stability 0 0.000 1.06
BLA alternative polyA 0 0.000 1.18
BLA alternative TSS 0 0.000 1.10
BLA gene expression 0 0.000 1.10
BLA isoform ratio 0 0.000 1.17
BLA intron excision ratio 0 0.000 1.11
BLA mRNA stability 1 0.050 1.14
Brain alternative polyA 0 0.000 1.16
Brain alternative TSS 0 0.000 1.19
Brain gene expression 0 0.000 1.06
Brain isoform ratio 0 0.000 1.12
Brain intron excision ratio 1 0.019 1.09
Brain mRNA stability 1 0.023 1.10
Eye alternative polyA 0 0.000 1.42
Eye alternative TSS 0 0.000 0.91
Eye gene expression 0 0.000 1.03
Eye isoform ratio 0 0.000 0.97
Eye intron excision ratio 0 0.000 1.05
Eye mRNA stability 0 0.000 1.15
IL alternative polyA 0 0.000 1.24
IL alternative TSS 0 0.000 1.00
IL gene expression 0 0.000 1.09
IL isoform ratio 0 0.000 1.21
IL intron excision ratio 0 0.000 1.11
IL mRNA stability 0 0.000 1.18
LHb alternative polyA 0 0.000 1.08
LHb alternative TSS 0 0.000 1.04
LHb gene expression 0 0.000 1.13
LHb isoform ratio 0 0.000 1.09
LHb intron excision ratio 0 0.000 1.13
LHb mRNA stability 0 0.000 1.16
Liver alternative polyA 0 0.000 1.16
Liver alternative TSS 0 0.000 1.19
Liver gene expression 0 0.000 1.05
Liver isoform ratio 0 0.000 1.13
Liver intron excision ratio 0 0.000 1.14
Liver mRNA stability 0 0.000 1.09
NAcc alternative polyA 0 0.000 1.20
NAcc alternative TSS 0 0.000 1.08
NAcc gene expression 0 0.000 1.08
NAcc isoform ratio 0 0.000 1.16
NAcc intron excision ratio 1 0.033 1.19
NAcc mRNA stability 0 0.000 1.13
OFC alternative polyA 0 0.000 1.18
OFC alternative TSS 0 0.000 1.32
OFC gene expression 0 0.000 1.10
OFC isoform ratio 0 0.000 1.11
OFC intron excision ratio 0 0.000 1.10
OFC mRNA stability 0 0.000 1.09
PL alternative polyA 0 0.000 1.13
PL alternative TSS 0 0.000 1.11
PL gene expression 0 0.000 1.08
PL isoform ratio 0 0.000 1.15
PL intron excision ratio 0 0.000 1.14
PL mRNA stability 1 0.034 1.13

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.