Hub : Genes

Prcp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Prcp 0.08 0.06 2.8e-07 0.04 0.04 0.04 0.04 1.3e-05 6.5e-05 2.2e-05 4.9e-05
2 Liver gene expression Prcp 0.61 0.16 0.0e+00 0.2 0.35 0.36 0.36 6.3e-22 8.3e-40 4.5e-41 3.4e-41
3 Brain mRNA stability Prcp 0.15 0.1 1.0e-08 0.09 0.09 0.09 0.09 2.0e-08 5.7e-09 1.3e-08 1.6e-08
4 Adipose mRNA stability Prcp 0.16 0.1 2.2e-09 0.07 0.06 0.07 0.07 3.2e-08 9.7e-08 7.5e-08 5.9e-08
5 Brain gene expression Prcp 0.19 0.11 2.5e-11 0.12 0.12 0.11 0.11 1.1e-11 3.5e-11 9.1e-11 9.3e-11
6 RMTg mRNA stability Prcp 0.16 0.11 2.4e-03 0.07 0.05 0.04 0.05 5.1e-03 1.7e-02 3.4e-02 1.5e-02
7 RMTg gene expression Prcp 0.3 0.16 9.3e-07 0.26 0.25 0.25 0.26 9.0e-08 2.9e-07 2.1e-07 1.3e-07
8 LHb gene expression Prcp 0.27 0.15 7.1e-04 0.06 0.14 0.02 0.13 1.8e-02 3.7e-04 8.9e-02 5.3e-04
9 pVTA gene expression Prcp 0.19 0.12 5.4e-05 0.06 0.12 0.11 0.12 1.2e-03 1.1e-05 1.4e-05 8.4e-06
10 BLA gene expression Prcp 0.12 0.09 5.7e-05 0.02 0.07 0.06 0.06 4.7e-02 1.2e-04 3.1e-04 4.0e-04
11 NAcc gene expression Prcp 0.2 0.13 5.6e-17 0.08 0.14 0.18 0.17 2.5e-09 4.5e-16 9.0e-21 8.2e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.11.92.9-0.51.3-1.61.71.6-0.5-0.4-1.7-1.5-1.61.6
Area under the delay curve0.20.20.40.5-0.60.6-0.6-0.6-0.3-0.20.40.40.30.3
BMI with tail0.72.34.7-0.11.1-1.61.71.7-0.9-0.7-1.9-1.7-1.82.2
BMI without tail1.43.05.9-2.12.4-2.22.02.11.11.4-1.4-1.0-1.01.3
Body weight0.52.03.7-1.61.9-1.91.81.80.60.2-1.4-1.3-1.10.9
Weight adjusted by age1.51.74.7-2.00.9-0.2-0.4-0.22.21.60.91.01.3-1.7
Bone surface0.30.50.9-0.60.9-0.91.00.90.10.1-0.8-0.6-0.60.6
Bone volume0.50.81.4-0.81.2-1.21.21.10.1-0.1-1.0-0.9-0.80.7
Breakpoint value in progressive ratio session0.50.51.10.5-0.71.0-0.8-1.0-0.2-0.00.80.90.7-0.4
Number of licking bursts0.70.81.4-0.71.1-1.21.11.10.00.1-1.0-0.9-0.90.7
Context. condit. distance diff. score0.91.13.11.7-1.10.4-0.2-0.2-1.8-1.5-0.5-0.7-0.80.9
Locomotion velocity, session 11.31.42.61.0-1.61.5-1.6-1.5-0.20.01.31.11.1-0.8
Locomotion distance, session 11.41.83.01.2-1.71.7-1.7-1.7-0.2-0.11.41.31.2-1.2
Locomotion velocity, session 20.50.61.00.7-1.01.0-1.0-0.9-0.1-0.30.80.60.6-0.7
Locomotion distance, session 22.23.15.61.5-2.22.4-2.3-2.2-0.2-0.51.91.51.6-1.6
Locomotion velocity, session 31.21.43.0-0.8-0.10.6-0.8-0.81.41.71.21.41.4-1.6
Locomotion distance, session 30.70.71.40.4-0.81.0-1.0-1.00.30.41.01.00.9-1.2
Stereotopy head waving bouts, day 30.50.61.6-1.31.2-0.90.80.80.81.0-0.4-0.2-0.1-0.2
Stereotopy head waving duration, day 30.20.20.60.5-0.2-0.10.20.2-0.8-0.5-0.4-0.5-0.60.6
Locomotion velocity, session 71.51.64.52.1-1.60.8-0.6-0.5-2.0-1.9-0.3-0.6-0.70.8
Locomotion distance, session 71.51.95.42.3-2.01.3-1.1-1.0-2.0-2.00.2-0.3-0.30.2
Stereotopy head waving bouts, day 70.20.20.6-0.70.6-0.40.30.30.50.7-0.10.00.10.0
Stereotopy head waving duration, day 70.20.20.7-0.70.6-0.30.20.30.60.80.00.10.20.0
Locomotion velocity, session 82.02.46.62.2-1.40.2-0.10.1-2.6-2.6-1.0-1.4-1.51.0
Locomotion distance, session 81.72.56.62.6-2.41.8-1.6-1.5-1.9-1.90.70.20.1-0.1
Degree of sensitization distance1.01.02.31.0-0.4-0.20.30.4-1.4-1.5-0.9-1.1-1.11.3
Degree of sensitization stereotypy0.00.00.2-0.20.2-0.20.20.10.20.3-0.1-0.1-0.00.4
Conditioned locomotion2.12.44.21.3-1.92.0-2.0-2.0-0.1-0.21.71.41.4-1.4
Cocaine response after cond. corrected1.31.43.4-1.81.8-1.51.31.31.21.0-0.8-0.6-0.40.0
Cocaine response after cond. not corrected0.30.40.9-1.00.9-0.70.60.60.70.7-0.2-0.1-0.00.0
Cocaine response before conditioning0.60.71.51.2-1.21.0-0.9-1.0-0.8-0.60.60.50.30.2
Saline control response0.91.22.00.2-0.91.3-1.3-1.30.60.61.41.31.4-1.1
Bone: connectivity density0.91.43.00.20.7-1.21.31.2-1.0-0.7-1.5-1.4-1.51.7
Bone: cortical apparent density0.30.51.40.9-0.4-0.00.20.1-1.2-1.0-0.5-0.6-0.80.6
Bone: cortical area0.30.51.4-1.21.0-0.70.60.60.90.8-0.2-0.00.1-0.5
Bone: cortical porosity0.10.20.3-0.60.6-0.50.40.50.30.1-0.3-0.3-0.2-0.1
Bone: cortical porosity0.50.51.0-0.81.0-1.00.91.00.30.1-0.8-0.7-0.60.1
Bone: cortical thickness0.10.20.4-0.40.6-0.60.60.60.1-0.1-0.5-0.5-0.4-0.0
Bone: cortical thickness0.50.61.00.3-0.71.0-0.9-1.00.3-0.01.00.90.9-1.0
Bone: cortical tissue density0.40.51.41.0-0.40.00.20.1-1.2-1.0-0.5-0.6-0.70.6
Condit. Reinf. active minus inactive responses0.91.02.1-1.31.5-1.31.21.20.60.6-0.8-0.6-0.6-0.2
Condit. Reinf. active-inactive response ratio1.82.03.8-1.41.9-1.91.81.80.40.5-1.5-1.1-1.20.7
Condit. Reinf. active responses0.30.41.0-1.00.9-0.60.50.40.90.8-0.10.10.1-0.8
Condit. Reinf. inactive responses0.60.81.9-0.0-0.50.9-0.9-0.90.70.51.11.01.1-1.4
Incentive salience index mean0.50.61.3-0.91.2-1.11.01.00.40.4-0.7-0.6-0.5-0.1
Condit. Reinf. lever presses0.10.20.50.7-0.50.2-0.1-0.2-0.7-0.6-0.1-0.2-0.30.0
Condit. Reinf. active minus inactive responses1.31.63.81.8-1.91.7-1.5-1.5-1.1-0.90.90.60.5-0.0
Condit. Reinf. active-inactive response ratio1.31.43.61.8-1.30.7-0.4-0.4-1.8-1.9-0.3-0.7-0.71.0
Condit. Reinf. active responses2.53.56.21.6-2.32.5-2.4-2.4-0.20.12.11.91.8-1.2
Condit. Reinf. inactive responses2.73.46.1-0.8-0.51.3-1.6-1.61.92.22.22.52.3-2.2
Condit. Reinf. lever presses4.96.614.53.4-3.83.4-3.1-3.1-1.7-1.42.21.71.5-1.0
Condit. Reinf. lever reinforcers received2.23.15.51.6-2.22.4-2.3-2.2-0.3-0.02.01.81.6-1.2
Conditioned reinforcement - actives0.70.71.71.0-0.3-0.20.40.4-1.2-1.3-0.7-0.9-0.90.5
Conditioned reinforcement - inactives1.21.43.3-1.71.8-1.41.31.31.21.0-0.7-0.5-0.2-0.5
Conditioned locomotion0.40.50.9-0.20.7-0.80.90.9-0.2-0.3-0.8-0.9-0.70.8
Patch foraging indifference point 0 sec0.20.41.40.9-0.60.4-0.2-0.2-0.9-1.2-0.1-0.3-0.30.4
Patch foraging indifference point AUC0.20.20.4-0.0-0.40.5-0.6-0.60.20.50.60.60.5-0.3
Delay disc. indifference point, 0s delay1.41.63.0-0.9-0.10.8-1.0-1.01.31.61.51.71.6-1.2
Delay disc. indifference point, 16s delay1.41.43.41.8-1.81.5-1.3-1.3-1.3-1.10.70.40.30.7
Delay disc. indifference point, 2s delay0.10.10.2-0.40.10.1-0.2-0.20.50.40.40.50.4-0.1
Delay disc. indifference point, 24s delay0.40.41.01.0-0.90.7-0.5-0.6-0.8-0.50.20.2-0.00.8
Delay disc. indifference point, 4s delay1.01.11.9-0.81.4-1.31.41.40.10.1-1.1-1.0-0.90.8
Delay disc. indifference point, 8s delay1.01.01.90.7-1.21.4-1.4-1.4-0.2-0.01.11.10.9-0.3
Indifference point function ln k0.30.51.61.1-0.90.6-0.4-0.4-0.9-1.20.0-0.2-0.2-0.2
Indifference point function log k0.30.51.61.1-0.90.6-0.4-0.4-0.9-1.20.0-0.2-0.2-0.2
Patch foraging total patch changes 0 sec0.30.51.41.0-0.90.6-0.4-0.4-1.0-1.20.0-0.1-0.20.4
Patch foraging total patch changes 12 sec0.60.71.3-0.5-0.30.8-0.9-0.90.80.81.01.11.0-0.7
Patch foraging total patch changes 18 sec0.10.10.2-0.20.2-0.20.20.2-0.2-0.3-0.3-0.3-0.30.4
Patch foraging total patch changes 24 sec0.10.10.3-0.60.10.1-0.2-0.20.50.50.30.50.4-0.1
Patch foraging total patch changes 6 sec0.00.10.40.1-0.0-0.00.10.1-0.3-0.2-0.2-0.1-0.20.7
Patch foraging time to switch 0 sec1.82.76.4-2.52.5-2.01.81.81.61.8-0.9-0.5-0.40.4
Patch foraging water rate 0 sec1.52.37.02.6-2.21.5-1.2-1.2-2.0-2.00.30.0-0.20.7
Patch foraging water rate 12 sec3.04.613.73.7-2.81.7-1.2-1.2-3.2-3.0-0.0-0.6-0.71.5
Patch foraging water rate 18 sec2.53.411.03.3-2.51.6-1.2-1.2-2.5-2.50.2-0.3-0.41.1
Patch foraging water rate 24 sec1.62.24.91.9-0.6-0.30.60.6-2.2-2.0-1.3-1.5-1.62.1
Patch foraging water rate 6 sec1.72.47.12.7-1.91.0-0.6-0.6-2.3-2.4-0.3-0.7-0.81.3
Seeking ratio, delayed vs. immediate footshock0.40.51.0-0.60.9-0.91.01.00.20.1-0.8-0.7-0.60.1
Distance traveled before self-admin0.30.30.8-0.60.10.1-0.4-0.30.70.90.50.70.6-0.7
Distance traveled after self-admin0.70.81.9-1.20.40.2-0.5-0.41.41.10.80.91.0-1.1
Extensor digitorum longus weight0.20.92.01.3-1.41.3-1.2-1.2-0.7-0.70.80.50.5-0.1
Bone: elastic displacement0.40.41.01.0-0.90.7-0.6-0.6-0.7-1.00.30.10.1-0.2
Bone: elastic work0.30.40.91.0-0.90.6-0.6-0.6-0.7-0.80.20.10.0-0.4
Bone: endosteal estimation0.51.13.0-1.61.1-0.40.30.21.71.60.50.70.8-1.0
Bone: endosteal perimeter0.30.61.5-1.20.9-0.40.30.31.21.10.20.40.5-0.5
Epididymis fat weight1.43.35.1-0.91.8-2.22.22.3-0.4-0.3-2.1-2.0-2.02.1
Delta time in closed arm before/after self-admin1.31.22.50.3-1.01.2-1.4-1.40.20.91.31.61.2-0.8
Delta time in open arm before/after self-admin0.80.81.70.10.5-0.91.01.1-0.5-0.9-1.1-1.3-1.10.6
Diff in mean of infusions in LGA sessions0.10.10.1-0.20.3-0.30.30.30.2-0.2-0.2-0.3-0.1-0.1
Delay discount exponential model param0.20.20.5-0.60.7-0.60.50.60.50.3-0.3-0.2-0.2-0.4
Extinction: sum of active levers before priming0.20.20.70.1-0.20.4-0.3-0.50.1-0.00.40.40.4-0.8
Active lever presses in extinction session 61.41.32.7-0.4-0.31.0-1.2-1.20.91.11.41.61.5-1.3
Bone: final force0.30.50.8-0.2-0.30.6-0.7-0.70.70.50.90.90.9-0.9
Bone: final moment0.20.30.5-0.1-0.30.5-0.6-0.60.50.30.70.70.7-0.7
Food consumed during 24 hour testing period0.40.50.8-0.50.8-0.90.90.80.10.2-0.7-0.6-0.60.6
Glucose0.60.82.51.4-0.90.3-0.1-0.1-1.6-1.3-0.5-0.6-0.80.9
Heart weight0.10.20.60.8-0.50.2-0.0-0.1-0.7-0.7-0.2-0.1-0.30.3
Delay discount hyperbolic model param0.10.10.2-0.30.3-0.30.20.20.30.2-0.1-0.1-0.0-0.4
Intermittent access intake day 1-15 change0.70.71.50.9-0.3-0.10.40.4-1.2-1.1-0.7-0.9-0.91.2
Intermittent access intake escalation0.50.51.30.9-0.50.20.00.1-1.1-1.1-0.4-0.6-0.60.9
Intermittent access intake escalation 20.10.10.30.3-0.40.4-0.4-0.4-0.1-0.10.30.20.20.6
Intermitt. access day 1 inactive lever presses1.31.44.2-2.11.5-0.90.60.61.81.80.20.40.6-0.5
Intermitt. access day 15 inactive lever presses0.10.10.3-0.50.5-0.40.40.40.20.5-0.2-0.0-0.0-0.3
Intermitt. access escalation Index0.30.30.80.10.3-0.40.50.5-0.4-0.9-0.6-0.9-0.6-0.0
Intermittent access day 1 total infusions0.10.20.3-0.20.5-0.50.60.50.00.0-0.4-0.5-0.3-0.0
Intermittent access day 15 total infusions0.91.01.80.70.2-0.60.90.9-1.2-1.1-1.1-1.3-1.21.4
Intermittent access terminal intake (last 3 days)0.70.71.30.40.3-0.60.90.9-0.8-0.8-1.0-1.1-1.01.1
Intermittent access total infusions1.21.32.20.40.6-1.11.31.3-0.9-0.8-1.4-1.5-1.41.2
Intermittent access day 1 locomotion0.70.71.6-1.01.3-1.11.11.00.60.6-0.7-0.6-0.40.2
Intermittent access day 15 total locomotion0.80.91.5-0.10.8-1.01.21.2-0.4-0.4-1.1-1.2-1.01.0
Intermittent access total locomotion1.21.42.4-0.21.1-1.31.51.5-0.5-0.3-1.4-1.5-1.31.1
Intermittent access standard deviation0.20.30.6-0.70.8-0.60.60.60.40.1-0.4-0.5-0.2-0.1
Left kidney weight0.10.20.5-0.20.6-0.60.70.7-0.0-0.3-0.5-0.5-0.40.2
Right kidney weight0.20.50.90.7-0.80.9-0.8-0.9-0.1-0.50.70.60.6-0.8
Cocaine induced anxiety0.30.40.7-0.1-0.30.5-0.7-0.70.40.80.70.90.70.1
Post-drug Anxiety0.60.71.70.20.4-0.80.90.9-0.6-0.3-1.0-1.0-1.01.3
Baseline Anxiety2.02.23.80.70.5-1.21.61.6-1.4-1.4-1.8-2.0-1.91.4
Tail length1.03.08.7-3.02.4-1.51.11.12.62.4-0.10.20.6-0.7
Length with tail0.41.44.1-2.01.8-1.31.11.11.60.9-0.4-0.40.0-0.5
Length without tail0.20.30.70.6-0.80.7-0.6-0.6-0.3-0.90.40.20.2-0.6
Times rat made contact with spout0.40.50.90.40.2-0.50.60.6-0.8-0.8-0.9-1.0-0.90.7
Lifetime Intake0.60.71.30.30.5-0.81.01.0-0.7-0.6-1.1-1.1-1.10.8
Liver weight, left1.62.55.5-2.02.3-2.11.91.91.21.3-1.3-0.8-0.80.7
Liver weight, right1.52.65.9-2.32.4-2.01.81.81.61.5-1.0-0.6-0.50.3
Locomotor activity0.50.72.21.5-1.00.7-0.5-0.5-1.3-1.00.0-0.1-0.21.1
Locomotor testing distance0.30.51.71.0-0.50.3-0.1-0.1-1.0-0.7-0.2-0.4-0.41.3
Locomotor testing rearing0.00.00.30.00.00.00.00.0-0.10.0-0.0-0.0-0.00.6
Locomotion in novel chamber0.20.20.80.8-0.40.10.10.1-0.9-0.5-0.3-0.3-0.50.2
Locomotion in novel chamber post-restriction3.64.311.43.3-2.00.7-0.2-0.2-3.3-3.4-1.0-1.5-1.71.8
Fecal boli incidents, locomotor time 12.02.25.1-1.20.10.7-1.1-1.01.72.31.62.01.9-1.5
Change in fecal boli incidents, locomotor task2.42.33.71.00.2-1.01.31.3-1.8-1.6-1.8-1.9-1.91.8
Time >=10cm from walls, locomotor time 10.40.41.4-0.50.00.2-0.4-0.40.71.20.60.90.6-0.2
Bouts of movement, locomotor time 11.51.62.70.7-1.31.5-1.6-1.60.20.31.51.41.4-1.3
Total resting periods, locomotor time 11.01.12.01.1-1.41.4-1.4-1.4-0.4-0.21.11.00.9-0.7
Rest time, locomotor task time 10.10.20.50.7-0.50.4-0.3-0.3-0.5-0.60.1-0.1-0.00.2
Distance moved, locomotor task time 10.50.61.5-1.21.1-0.90.70.71.00.9-0.3-0.1-0.1-0.1
Vertical activity count, locomotor time 10.60.71.5-1.11.2-1.11.01.00.50.7-0.7-0.4-0.50.1
Time >=10cm from walls, locomotor time 20.80.92.3-1.20.50.1-0.4-0.41.21.50.81.11.1-0.9
Bouts of movement, locomotor time 23.33.66.0-0.4-1.11.9-2.2-2.21.51.42.42.52.4-1.9
Total resting periods, locomotor time 23.03.25.4-0.5-1.01.7-2.0-2.01.51.42.32.32.3-1.8
Rest time, locomotor task time 20.40.41.3-0.3-0.10.5-0.6-0.60.60.40.80.70.8-1.1
Distance moved, locomotor task time 20.60.71.7-1.31.2-1.00.90.81.00.9-0.4-0.2-0.10.2
Vertical activity count, locomotor time 22.12.34.4-1.82.1-2.01.91.90.91.1-1.3-1.0-0.90.9
Light reinforcement 10.71.42.20.3-1.01.4-1.4-1.40.50.41.51.41.5-1.2
Light reinforcement 20.20.30.90.2-0.40.6-0.6-0.60.4-0.10.70.40.7-1.0
Bone: marrow area0.51.02.9-1.61.1-0.40.30.21.71.60.40.70.8-0.9
Bone: maximum diameter0.30.61.6-1.20.8-0.30.10.11.31.10.40.50.6-0.6
Bone: maximum force0.10.10.50.0-0.30.4-0.4-0.40.20.00.40.40.4-0.7
Bone: maximum moment0.00.00.20.2-0.20.2-0.1-0.1-0.1-0.30.10.10.0-0.4
Mean time between licks in bursts0.10.20.4-0.50.6-0.60.50.50.20.2-0.4-0.3-0.30.4
Mean num. licks in bursts0.40.51.21.1-1.10.9-0.7-0.8-0.6-0.60.40.20.2-0.3
Cd content in liver2.32.54.1-0.91.7-1.92.02.0-0.2-0.5-1.8-1.8-1.61.4
Co content in liver0.50.60.9-0.0-0.50.8-0.9-0.80.50.30.90.90.9-0.9
Cu content in liver2.42.96.0-1.90.60.4-0.8-0.82.42.41.61.92.0-2.0
Fe content in liver0.10.10.4-0.40.2-0.0-0.1-0.10.40.60.20.40.3-0.2
K content in liver1.91.93.8-1.40.40.5-0.7-0.71.92.01.41.61.6-1.7
Mg content in liver1.41.53.3-1.30.40.4-0.6-0.61.71.81.21.41.4-1.4
Mn content in liver1.41.63.4-1.00.00.7-0.9-0.91.61.51.41.51.6-1.8
Na content in liver2.32.45.6-1.50.40.5-0.8-0.82.12.41.51.91.8-1.7
Rb content in liver0.30.41.3-0.40.00.3-0.4-0.40.61.20.60.90.7-0.3
Se content in liver2.12.66.8-2.21.1-0.0-0.3-0.32.62.21.21.51.7-2.1
Sr content in liver0.80.71.51.0-1.21.1-1.0-1.0-0.6-0.60.70.60.4-0.5
Zn content in liver1.11.32.00.3-1.01.3-1.4-1.40.40.41.41.31.3-1.0
Bone: minimum diameter1.22.35.3-2.22.3-1.91.81.71.31.1-1.1-0.8-0.60.2
Time in familiar zone, hab. session 10.60.51.20.7-0.2-0.30.40.4-1.0-0.7-0.7-0.7-0.91.1
Time in novel zone, hab. session 11.01.02.2-0.3-0.40.9-1.0-1.00.90.51.21.11.3-1.5
Total zone transitions, hab. session 11.11.53.70.2-1.01.3-1.4-1.30.70.61.51.41.4-1.9
Total locomotion distance, hab. session 11.62.36.1-2.51.7-0.80.50.52.41.90.40.71.0-2.0
Locomotion velocity, hab. session 11.92.77.5-2.72.1-1.20.90.92.52.20.20.50.7-1.7
Time in familiar zone, hab. session 20.30.40.70.6-0.80.8-0.8-0.8-0.1-0.10.60.50.5-0.2
Time in novel zone, hab. session 20.20.20.5-0.60.7-0.60.60.60.30.2-0.4-0.3-0.3-0.1
Total zone transitions, hab. session 20.81.01.70.9-1.21.3-1.2-1.3-0.10.11.10.90.9-1.0
Total locomotion distance, hab. session 21.01.33.5-1.91.4-0.70.60.51.71.70.20.40.6-1.1
Locomotion velocity, hab. session 21.11.53.8-1.81.2-0.30.20.11.91.90.60.81.0-1.5
Novel to familiar place preference ratio0.00.00.1-0.30.2-0.00.00.00.30.10.10.10.2-0.1
Novelty place preference0.10.10.2-0.2-0.00.2-0.2-0.20.40.10.40.40.4-0.3
Time in novel zone, NPP test0.10.10.20.2-0.40.4-0.4-0.40.0-0.20.40.40.4-0.3
Total zone transitions, NPP test0.50.72.01.4-1.31.0-0.8-0.8-1.0-0.60.40.20.1-0.5
Total locomotion distance, NPP test0.50.71.7-1.31.2-0.90.80.80.91.0-0.3-0.1-0.1-0.6
Locomotion velocity, NPP test0.71.02.6-1.61.5-1.11.00.91.21.2-0.3-0.10.0-0.7
Intraocular pressure0.60.82.51.6-1.10.5-0.3-0.3-1.4-1.3-0.2-0.4-0.60.8
Delta distance traveled before/after self-admin0.10.10.30.3-0.60.4-0.6-0.4-0.2-0.50.30.10.2-0.2
Delta ambulatory time before/after self-admin0.30.30.80.7-0.90.7-0.7-0.6-0.5-0.70.40.20.2-0.2
Parametrial fat weight0.81.52.5-0.61.3-1.51.61.6-0.3-0.5-1.5-1.4-1.30.9
Pavlov. Cond. lever latency0.30.40.9-0.50.00.3-0.4-0.40.91.00.70.80.8-0.8
Pavlov. Cond. magazine entry latency0.20.30.90.9-0.80.5-0.4-0.3-0.8-1.00.0-0.2-0.2-0.1
Pavlov. Cond. change in total contacts2.22.33.7-0.21.2-1.71.81.7-1.0-1.0-1.9-1.9-1.91.6
Pavlov. Cond. index score0.10.20.60.7-0.50.3-0.2-0.2-0.6-0.7-0.1-0.2-0.20.1
Pavlov. Cond. latency score0.10.10.30.3-0.1-0.00.10.1-0.4-0.6-0.2-0.3-0.30.2
Pavlov. Cond. lever contacts0.00.10.20.3-0.1-0.00.10.1-0.3-0.5-0.2-0.3-0.20.1
Pavlov. Cond. magazine entry number0.50.71.9-1.41.1-0.80.60.61.11.3-0.10.10.1-0.1
Pavlov. Cond. intertrial magazine entries0.91.12.2-1.01.5-1.41.51.30.20.2-1.1-0.9-0.90.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.8-0.50.2-0.1-0.1-0.8-0.9-0.3-0.4-0.40.3
Pavlov. Cond. response bias0.20.30.90.7-0.40.10.00.0-0.8-0.9-0.3-0.5-0.50.3
Pavlov. Cond. lever latency9.713.028.7-4.85.4-4.84.34.32.42.3-3.0-2.2-2.01.4
Pavlov. Cond. magazine entry latency2.93.49.83.1-2.61.8-1.5-1.5-2.4-2.40.4-0.1-0.21.1
Pavlov. Cond. change in total contacts4.86.614.73.5-3.83.4-3.1-3.1-1.7-1.72.11.61.4-0.8
Pavlov. Cond. index score6.78.619.64.1-4.43.8-3.4-3.5-2.2-2.12.31.71.4-0.6
Pavlov. Cond. latency score6.07.417.34.1-4.23.5-3.1-3.1-2.4-2.21.91.31.1-0.3
Pavlov. Cond. lever contacts7.810.723.84.5-4.94.3-3.9-3.9-2.3-2.22.61.91.7-1.3
Pavlov. Cond. magazine entry number4.85.914.9-3.93.7-2.92.52.62.52.4-1.4-0.8-0.6-0.5
Pavlov. Cond. intertrial magazine entries1.72.36.5-2.51.9-1.00.70.72.32.30.30.70.8-1.1
Pavlov. Cond. lever-magazine prob. diff.5.97.517.23.9-4.23.6-3.2-3.2-2.1-2.02.11.51.3-0.5
Pavlov. Cond. response bias8.211.124.44.4-4.94.4-4.0-4.0-2.2-2.22.82.11.9-1.3
Time in closed arm before self-admin0.10.10.30.4-0.20.10.1-0.0-0.4-0.5-0.2-0.3-0.30.2
Time in closed arm after self-admin0.10.10.20.5-0.40.4-0.3-0.4-0.30.40.20.40.10.4
Time in open arm before self-admin1.41.52.70.0-1.01.3-1.5-1.50.50.61.51.61.5-1.4
Time in open arm after self-admin0.10.10.3-0.0-0.20.2-0.3-0.20.1-0.20.20.10.2-0.5
Bone: periosteal estimation0.51.13.3-1.81.5-0.90.70.71.61.40.00.30.4-0.7
Bone: periosteal perimeter0.20.41.0-0.70.4-0.1-0.1-0.10.90.80.40.50.5-1.0
Bone: post-yield work0.10.10.30.30.1-0.20.40.3-0.5-0.6-0.4-0.5-0.50.2
Progressive ratio test 1 active lever presses0.40.40.9-0.71.0-0.80.90.80.40.0-0.6-0.8-0.40.2
Progressive ratio test 1 breakpoint0.50.51.0-0.51.0-0.91.01.00.2-0.2-0.8-0.9-0.60.3
Progressive ratio test 1 inactive lever presses0.40.51.0-0.71.0-0.90.90.90.30.3-0.6-0.6-0.4-0.2
Progressive ratio test 2 active lever presses1.71.83.10.21.0-1.51.81.7-0.8-0.6-1.7-1.8-1.60.9
Progressive ratio test 2 breakpoint1.71.93.50.01.2-1.61.91.8-0.6-0.6-1.8-1.8-1.70.9
Progressive ratio test 2 inactive lever presses0.40.50.80.50.2-0.50.70.7-0.8-0.7-0.8-0.9-0.90.4
Incentive Sensitization - Responses1.21.22.10.30.7-1.21.41.4-0.8-0.5-1.4-1.4-1.40.8
Incentive Sensitization - Breakpoint1.11.11.90.60.4-0.91.21.2-1.1-0.8-1.3-1.3-1.40.9
Sum of active levers in priming session hrs 5-60.10.10.30.3-0.40.4-0.4-0.4-0.3-0.60.20.10.2-0.4
Progressive ratio2.22.64.30.4-1.41.9-2.0-2.10.70.52.01.91.9-1.7
Food seeking constrained by brief footshock0.60.81.3-0.3-0.30.7-0.9-0.90.80.91.11.21.1-1.1
Seeking ratio, punishment vs. effort1.41.73.1-1.21.7-1.71.71.70.30.5-1.4-1.1-1.11.0
Retroperitoneal fat weight2.89.315.0-1.43.1-3.73.93.9-0.7-1.0-3.7-3.6-3.42.9
Reaction time number correct0.20.20.50.7-0.70.6-0.6-0.6-0.3-0.20.40.30.30.1
Reaction time mean minus median0.20.30.60.7-0.70.6-0.6-0.6-0.4-0.10.40.30.30.4
Reaction time mean minus median AUC0.10.10.40.6-0.50.4-0.3-0.3-0.4-0.20.20.10.10.4
Reaction time num false alarms2.12.86.6-2.52.6-2.11.91.91.61.5-1.1-0.6-0.60.6
Reaction time num false alarms AUC2.23.06.0-2.12.5-2.32.12.11.01.0-1.5-1.1-1.11.3
Reaction time trials correct on left0.20.20.50.7-0.70.6-0.6-0.6-0.3-0.20.40.30.30.1
Reaction time trials on left0.20.30.60.8-0.80.7-0.6-0.6-0.4-0.30.40.30.30.2
Reaction time mean0.10.10.20.3-0.40.4-0.5-0.50.10.10.50.40.5-0.2
Reaction time mean AUC0.00.00.00.2-0.10.1-0.2-0.20.00.00.20.10.2-0.0
Median of all reaction times0.10.10.20.3-0.40.4-0.5-0.50.0-0.10.40.30.4-0.4
Reaction time omissions0.50.61.81.3-0.80.3-0.2-0.2-1.3-1.1-0.3-0.6-0.50.9
Reaction time false alarm rate1.82.65.1-1.82.3-2.12.02.00.80.8-1.5-1.1-1.11.1
Reaction time premature initiation rate0.10.10.30.6-0.50.3-0.3-0.2-0.2-0.20.1-0.10.00.2
Reaction time premature initiations0.20.31.01.0-0.70.4-0.2-0.2-0.7-0.6-0.0-0.4-0.20.7
Std. dev. reaction times0.10.10.20.2-0.30.3-0.4-0.40.00.40.40.40.40.2
Reaction time trials completed0.20.30.60.8-0.80.7-0.6-0.6-0.4-0.30.40.30.30.2
Reaction time trials AUC0.10.20.40.6-0.60.6-0.5-0.6-0.3-0.20.40.30.30.2
Run reversals in cocaine runway, females0.10.10.3-0.40.2-0.1-0.1-0.00.50.60.20.30.3-0.3
Run reversals in cocaine runway, males1.61.64.52.0-1.20.5-0.2-0.2-2.0-2.1-0.6-0.9-1.01.0
Latency to leave start box in cocaine runway1.92.14.7-1.90.70.2-0.7-0.62.22.01.31.61.6-1.7
Latency to leave start box in cocaine runway, F3.74.06.3-1.90.01.0-1.7-1.62.52.22.22.42.5-2.4
Latency to leave start box in cocaine runway, M0.60.61.3-1.01.1-1.00.90.90.60.8-0.6-0.3-0.40.4
Std. dev. time between licks in bursts0.70.81.5-1.11.2-1.11.01.00.51.0-0.7-0.4-0.50.9
Total sessions with >9 infusions0.00.00.2-0.30.2-0.10.00.00.40.20.10.00.2-0.4
Short access day 1 total inactive lever presses2.42.75.3-0.61.7-2.12.32.3-0.3-0.2-2.0-1.9-1.80.9
Short access day 10 total inactive lever presses0.10.10.3-0.30.3-0.20.20.20.20.6-0.10.10.00.4
Short access day 1 total infusions0.60.61.2-0.50.9-1.01.11.10.2-0.1-0.9-0.9-0.70.2
Short access day 10 total infusions0.50.61.4-1.11.2-0.90.80.80.80.8-0.3-0.2-0.1-0.2
Short access total infusions0.20.20.5-0.50.7-0.60.60.60.40.2-0.4-0.3-0.2-0.1
Short access day 1 locomotion0.40.51.7-0.90.5-0.1-0.1-0.11.00.70.40.40.6-1.3
Short access day 10 total locomotion0.30.40.6-0.40.7-0.70.80.80.10.2-0.6-0.6-0.50.6
Short access total locomotion0.70.72.0-1.41.1-0.60.40.41.31.00.10.10.4-0.8
One hour access (0.3 mA shock)0.40.41.41.2-0.90.7-0.5-0.5-1.0-0.80.1-0.1-0.10.1
Compulsive drug intake0.40.41.4-0.4-0.10.3-0.5-0.50.70.40.60.60.7-1.2
One hour access (shock baseline)0.20.20.70.8-0.40.2-0.0-0.0-0.9-0.3-0.2-0.2-0.30.5
Social response proportion0.30.31.10.30.2-0.50.60.6-0.60.2-0.6-0.4-0.71.1
Social responses0.40.51.51.2-0.90.4-0.3-0.3-1.1-0.3-0.10.1-0.30.9
Social time0.60.81.6-1.21.3-1.00.90.90.81.2-0.5-0.1-0.20.5
Soleus weight0.20.51.4-1.21.2-0.70.80.51.00.9-0.2-0.10.1-0.1
Bone: stiffness0.00.10.2-0.40.4-0.30.30.30.2-0.0-0.2-0.2-0.1-0.1
Tibialis anterior weight0.10.20.50.4-0.70.7-0.7-0.6-0.0-0.20.60.40.5-0.2
Time to tail flick, vehicle, before self-admin0.50.50.90.6-0.80.9-0.8-1.0-0.3-0.60.70.50.5-0.7
Time to tail flick, vehicle, after self-admin0.60.61.80.9-0.90.8-0.7-0.7-0.6-1.20.30.10.1-1.3
Time to tail flick, test, before self-admin0.80.72.3-1.51.2-0.80.60.61.31.1-0.1-0.00.2-0.2
Time to tail flick, test, after self-admin2.22.34.0-1.20.01.0-1.2-1.41.81.81.82.02.0-1.3
Delta time to tail flick, vehicle, before/after SA0.30.30.90.7-0.80.5-0.6-0.4-0.5-0.70.2-0.00.1-1.0
Delta time to tail flick, test, before/after SA1.11.02.0-0.2-0.51.0-1.1-1.20.70.91.21.41.2-0.9
Tibia length1.13.15.7-1.30.00.9-1.2-1.22.32.41.92.22.2-2.0
Ambulatory time before self-admin0.20.20.3-0.50.6-0.50.40.50.30.6-0.3-0.1-0.10.2
Ambulatory time after self-admin0.10.10.2-0.3-0.00.1-0.3-0.20.30.30.30.30.4-0.5
Bone: tissue strength4.74.68.11.00.6-1.71.91.9-2.4-1.8-2.6-2.7-2.92.7
Total heroin consumption0.50.61.61.2-1.00.3-0.5-0.1-1.3-0.9-0.3-0.5-0.51.1
Bone: trabecular number0.71.12.20.20.6-1.01.11.1-0.9-0.8-1.3-1.3-1.31.5
Bone: trabecular spacing0.20.20.40.5-0.50.7-0.4-0.6-0.1-0.10.50.40.4-0.5
Bone: trabecular thickness0.40.51.0-0.70.9-1.00.80.90.2-0.1-0.8-0.7-0.60.3
Bone: trabecular tissue density2.02.85.6-1.30.10.7-1.1-1.02.12.31.72.02.0-2.4
Water consumed over 24 hours0.50.61.0-0.00.6-0.90.90.9-0.6-0.6-1.0-1.0-1.00.8
Number of responses in last shaping day2.32.46.5-2.51.6-0.60.20.12.62.50.71.21.2-1.2