Hub : Genes

Prcp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Prcp 0.62 0.17 0.0e+00 0.28 0.34 0.35 0.35 7.3e-32 4.1e-39 1.0e-40 1.2e-40
2 Adipose mRNA stability Prcp 0.15 0.1 2.7e-09 0.06 0.06 0.06 0.07 4.3e-07 1.1e-07 1.3e-07 5.4e-08
3 Brain mRNA stability Prcp 0.15 0.09 8.8e-09 0.1 0.09 0.09 0.1 2.0e-09 9.6e-09 1.1e-08 2.6e-09
4 RMTg gene expression Prcp 0.29 0.16 5.0e-06 0.16 0.16 0.17 0.17 4.4e-05 4.4e-05 3.1e-05 3.2e-05
5 Adipose gene expression Prcp 0.13 0.08 1.9e-12 0.08 0.07 0.08 0.08 2.1e-09 1.5e-08 4.0e-09 4.4e-09
6 BLA mRNA stability Prcp 0.05 0.04 8.9e-03 0.03 0.02 0.02 0.02 7.0e-03 2.7e-02 2.4e-02 2.9e-02
7 Brain gene expression Prcp 0.37 0.15 0.0e+00 0.24 0.28 0.27 0.27 5.2e-22 1.1e-26 2.1e-25 8.4e-25
8 LHb gene expression Prcp 0.3 0.16 2.1e-04 0.08 0.15 0.06 0.15 6.8e-03 2.5e-04 2.0e-02 2.5e-04
9 PL gene expression Prcp 0.12 0.07 6.2e-11 0.07 0.1 0.1 0.1 2.4e-08 1.7e-10 8.9e-11 1.1e-10
10 IC gene expression Prcp 0.07 0.06 8.3e-03 0.02 0.04 0.06 0.05 5.1e-02 5.5e-03 2.3e-03 4.3e-03
11 BLA gene expression Prcp 0.39 0.21 6.2e-15 0.13 0.26 0.27 0.26 1.8e-07 2.7e-14 2.1e-14 4.7e-14
12 NAcc gene expression Prcp 0.26 0.11 0.0e+00 0.18 0.27 0.29 0.28 3.6e-27 2.7e-40 1.7e-44 5.2e-43
13 pVTA gene expression Prcp 0.29 0.15 0.0e+00 0.17 0.23 0.27 0.26 1.1e-13 1.7e-18 1.1e-21 1.1e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.91.73.0-1.3-1.71.7-0.00.40.4-1.7-1.61.21.21.31.41.4
Area under the delay curve0.10.20.40.70.7-0.7-0.30.20.20.50.5-0.1-0.3-0.2-0.1-0.2
BMI with tail0.93.15.7-1.5-2.42.4-0.10.60.5-2.3-2.31.71.61.91.81.6
BMI without tail0.42.35.5-2.1-2.42.41.0-0.2-0.3-2.0-1.90.70.51.31.41.2
Body weight1.04.411.0-3.2-3.33.31.4-0.9-0.9-2.7-2.50.91.11.51.41.2
Weight adjusted by age0.72.14.8-1.60.3-0.32.0-2.2-2.10.70.9-1.9-1.5-1.6-1.2-0.9
Bone surface0.10.30.7-0.8-0.90.90.3-0.2-0.2-0.7-0.60.30.30.30.40.4
Bone volume0.30.61.3-1.1-1.21.20.4-0.2-0.3-1.0-0.90.50.50.50.60.6
Breakpoint value in progressive ratio session0.30.51.81.30.9-0.9-1.01.00.90.40.30.60.20.10.10.1
Number of licking bursts0.20.61.3-1.1-1.11.10.3-0.1-0.1-1.0-1.00.40.50.70.70.7
Context. condit. distance diff. score1.11.33.01.20.2-0.2-1.71.71.7-0.4-0.51.31.21.11.00.9
Locomotion velocity, session 11.01.12.61.51.6-1.6-0.40.20.21.31.3-0.7-0.7-0.8-1.0-1.0
Locomotion distance, session 11.01.32.81.61.7-1.7-0.50.20.21.51.4-0.8-0.8-0.9-1.1-1.0
Locomotion velocity, session 20.30.41.01.01.0-1.0-0.40.20.10.80.8-0.2-0.3-0.5-0.6-0.6
Locomotion distance, session 21.62.25.02.12.2-2.2-0.80.20.22.01.8-0.7-0.8-1.2-1.4-1.3
Locomotion velocity, session 31.71.93.3-0.20.9-0.91.4-1.5-1.41.21.3-1.6-1.7-1.5-1.8-1.6
Locomotion distance, session 30.50.61.10.71.0-1.00.1-0.3-0.21.00.9-0.7-0.7-0.8-1.1-0.9
Stereotopy head waving bouts, day 30.40.51.5-1.2-0.80.81.1-0.9-0.9-0.4-0.3-0.4-0.4-0.2-0.2-0.1
Stereotopy head waving duration, day 30.30.30.50.2-0.30.3-0.60.70.7-0.4-0.50.60.60.70.60.7
Locomotion velocity, session 71.51.74.31.60.6-0.6-2.11.91.9-0.1-0.31.41.31.10.91.0
Locomotion distance, session 71.41.74.92.01.0-1.0-2.21.81.90.30.11.21.20.80.50.6
Stereotopy head waving bouts, day 70.00.10.2-0.4-0.30.30.4-0.2-0.3-0.2-0.2-0.0-0.10.0-0.00.0
Stereotopy head waving duration, day 70.10.10.4-0.6-0.30.30.6-0.5-0.5-0.1-0.0-0.3-0.3-0.2-0.2-0.2
Locomotion velocity, session 82.73.26.81.50.1-0.1-2.62.62.6-0.9-1.12.12.11.91.51.7
Locomotion distance, session 81.42.06.22.51.5-1.5-2.31.91.90.80.51.00.90.40.20.3
Degree of sensitization distance1.21.32.10.5-0.30.3-1.41.41.4-0.8-0.91.41.41.21.31.2
Degree of sensitization stereotypy0.00.00.1-0.2-0.20.20.2-0.1-0.2-0.1-0.10.0-0.0-0.00.10.0
Conditioned locomotion1.51.83.91.82.0-2.0-0.50.20.11.81.7-0.8-0.8-1.2-1.3-1.2
Cocaine response after cond. corrected0.71.13.7-1.9-1.31.31.5-1.3-1.3-0.8-0.6-0.5-0.3-0.1-0.0-0.0
Cocaine response after cond. not corrected0.20.30.9-1.0-0.50.50.9-0.8-0.8-0.2-0.1-0.5-0.4-0.3-0.2-0.2
Cocaine response before conditioning0.50.62.01.41.0-1.0-1.10.90.90.60.50.20.20.0-0.0-0.0
Saline control response1.62.33.50.91.7-1.70.6-1.0-1.01.91.9-1.5-1.5-1.8-1.7-1.8
Bone: connectivity density0.91.52.2-0.6-1.31.3-0.50.90.8-1.5-1.51.31.21.41.51.4
Bone: cortical apparent density0.50.81.60.6-0.20.2-1.11.31.3-0.6-0.70.90.91.01.00.9
Bone: cortical area0.40.61.4-1.1-0.50.51.2-1.1-1.1-0.1-0.0-0.7-0.6-0.5-0.6-0.4
Bone: cortical porosity0.30.30.5-0.6-0.70.7-0.10.10.1-0.7-0.70.40.60.60.40.5
Bone: cortical porosity0.30.41.1-1.0-0.90.90.4-0.3-0.3-0.8-0.70.20.30.40.20.4
Bone: cortical thickness0.00.10.2-0.5-0.40.40.2-0.2-0.2-0.3-0.3-0.00.10.10.00.1
Bone: cortical thickness0.40.50.90.40.8-0.80.1-0.5-0.50.90.9-0.9-0.6-0.9-0.8-0.8
Bone: cortical tissue density0.50.71.60.7-0.20.2-1.11.21.3-0.5-0.60.90.81.01.00.9
Condit. Reinf. active minus inactive responses0.60.62.2-1.5-1.21.20.9-0.6-0.7-0.9-0.8-0.00.00.30.10.3
Condit. Reinf. active-inactive response ratio1.31.43.4-1.8-1.81.80.9-0.4-0.5-1.5-1.40.40.40.80.80.8
Condit. Reinf. active responses0.30.30.9-1.0-0.50.51.0-0.8-0.9-0.2-0.1-0.5-0.4-0.3-0.5-0.3
Condit. Reinf. inactive responses0.60.71.30.40.9-0.90.3-0.6-0.61.01.0-0.8-0.8-1.0-1.2-0.9
Incentive salience index mean0.30.41.3-1.1-1.01.00.6-0.3-0.4-0.8-0.70.10.10.30.20.3
Condit. Reinf. lever presses0.10.20.50.50.0-0.0-0.60.70.7-0.1-0.20.50.40.40.30.3
Condit. Reinf. active minus inactive responses0.81.24.12.01.6-1.6-1.41.11.01.10.90.20.1-0.2-0.3-0.3
Condit. Reinf. active-inactive response ratio1.01.54.01.50.4-0.4-2.01.81.7-0.2-0.41.51.41.00.91.0
Condit. Reinf. active responses2.02.86.12.32.5-2.5-0.60.20.22.22.1-1.1-1.2-1.4-1.6-1.5
Condit. Reinf. inactive responses2.84.27.10.21.6-1.61.7-1.9-1.82.12.2-2.6-2.7-2.3-2.4-2.4
Condit. Reinf. lever presses3.45.015.84.03.4-3.4-2.21.71.62.62.3-0.2-0.5-1.0-1.2-1.3
Condit. Reinf. lever reinforcers received1.82.55.42.22.3-2.3-0.70.30.22.11.9-0.9-1.1-1.3-1.4-1.4
Conditioned reinforcement - actives0.10.20.6-0.0-0.40.4-0.50.40.3-0.5-0.50.50.80.50.40.5
Conditioned reinforcement - inactives0.20.61.7-1.3-1.21.20.7-0.6-0.7-0.9-0.80.00.40.30.10.2
Conditioned locomotion0.10.10.3-0.4-0.10.10.4-0.5-0.50.00.1-0.3-0.1-0.3-0.1-0.2
Patch foraging indifference point 0 sec0.10.41.00.70.3-0.3-1.00.70.8-0.0-0.10.90.80.40.60.5
Patch foraging indifference point AUC0.10.20.40.60.6-0.6-0.2-0.00.30.50.5-0.4-0.4-0.1-0.3-0.2
Delay disc. indifference point, 0s delay1.92.13.60.01.0-1.01.5-1.4-1.51.31.4-1.7-1.8-1.7-1.6-1.9
Delay disc. indifference point, 16s delay0.70.93.21.81.3-1.3-1.41.21.10.80.60.40.20.00.10.1
Delay disc. indifference point, 2s delay0.10.10.1-0.00.2-0.20.3-0.4-0.30.30.3-0.3-0.4-0.4-0.2-0.3
Delay disc. indifference point, 24s delay0.20.20.80.90.6-0.6-0.70.70.70.30.20.3-0.00.10.20.2
Delay disc. indifference point, 4s delay0.80.82.0-1.2-1.41.40.4-0.1-0.2-1.2-1.10.50.60.70.80.6
Delay disc. indifference point, 8s delay0.50.81.91.11.4-1.4-0.30.00.11.21.1-0.5-0.7-0.8-0.5-0.6
Indifference point function ln k0.20.51.41.00.5-0.5-1.20.90.80.10.00.90.80.30.30.4
Indifference point function log k0.20.51.41.00.5-0.5-1.20.90.80.10.00.90.80.30.30.4
Patch foraging total patch changes 0 sec0.10.41.10.80.4-0.4-1.00.80.90.0-0.10.90.70.40.60.5
Patch foraging total patch changes 12 sec0.40.50.80.10.8-0.80.5-0.8-0.40.80.9-0.8-0.9-0.8-0.8-0.7
Patch foraging total patch changes 18 sec0.10.30.6-0.5-0.60.6-0.20.10.4-0.7-0.60.80.60.60.60.7
Patch foraging total patch changes 24 sec0.00.10.3-0.5-0.20.20.5-0.6-0.4-0.00.0-0.2-0.4-0.20.0-0.2
Patch foraging total patch changes 6 sec0.10.10.3-0.1-0.20.2-0.20.20.5-0.3-0.30.50.30.40.40.4
Patch foraging time to switch 0 sec0.62.26.9-2.6-1.81.82.2-1.8-1.8-1.1-0.8-0.6-0.7-0.2-0.2-0.1
Patch foraging water rate 0 sec0.52.05.22.31.2-1.2-2.32.22.10.40.21.11.00.70.80.6
Patch foraging water rate 12 sec1.04.111.13.01.2-1.2-3.33.22.80.2-0.22.11.91.31.41.0
Patch foraging water rate 18 sec1.32.87.02.61.3-1.3-2.72.62.40.40.11.51.30.91.10.8
Patch foraging water rate 24 sec2.02.95.50.9-0.60.6-2.12.32.1-1.2-1.32.02.01.81.91.7
Patch foraging water rate 6 sec2.02.97.12.10.6-0.6-2.62.72.4-0.2-0.51.91.71.41.51.4
Seeking ratio, delayed vs. immediate footshock0.20.41.0-1.0-0.90.90.6-0.5-0.6-0.7-0.60.00.20.20.00.1
Distance traveled before self-admin0.00.00.1-0.1-0.20.20.3-0.0-0.1-0.2-0.2-0.1-0.20.1-0.1-0.1
Distance traveled after self-admin0.20.30.8-0.50.0-0.00.9-0.8-0.80.20.3-0.6-0.7-0.6-0.6-0.6
Extensor digitorum longus weight0.10.61.61.31.2-1.2-0.70.40.40.90.8-0.0-0.1-0.4-0.3-0.4
Bone: elastic displacement0.30.31.01.00.8-0.8-0.70.50.50.60.50.00.1-0.2-0.2-0.2
Bone: elastic work0.20.20.80.90.7-0.7-0.60.50.50.50.4-0.0-0.1-0.1-0.3-0.2
Bone: endosteal estimation0.61.53.6-1.2-0.20.21.9-1.8-1.80.40.6-1.3-1.4-1.2-1.2-1.1
Bone: endosteal perimeter0.40.92.2-1.1-0.30.31.5-1.4-1.40.20.3-0.9-1.0-0.8-0.8-0.8
Epididymis fat weight1.36.410.7-2.2-3.33.3-0.30.91.1-3.3-3.22.42.22.82.82.8
Delta time in closed arm before/after self-admin0.60.51.30.50.8-0.80.5-0.2-0.30.80.8-0.8-1.1-0.7-0.7-1.0
Delta time in open arm before/after self-admin1.51.83.7-0.3-1.31.3-1.21.11.1-1.4-1.51.51.91.61.21.4
Diff in mean of infusions in LGA sessions0.50.81.60.1-0.70.7-0.90.90.8-0.9-0.91.11.31.00.81.0
Delay discount exponential model param0.10.20.6-0.7-0.60.60.5-0.4-0.4-0.4-0.4-0.10.10.1-0.1-0.0
Extinction: sum of active levers before priming0.00.00.10.40.3-0.3-0.20.10.10.20.10.10.1-0.0-0.2-0.1
Active lever presses in extinction session 60.30.30.70.90.8-0.8-0.20.40.20.60.6-0.2-0.4-0.4-0.2-0.4
Bone: final force0.61.01.50.30.9-0.90.7-0.9-0.91.11.2-1.1-1.2-1.2-1.2-1.2
Bone: final moment0.50.71.10.30.8-0.80.5-0.7-0.71.01.0-0.9-1.0-1.0-1.1-1.0
Food consumed during 24 hour testing period0.20.30.7-0.8-0.80.80.4-0.2-0.1-0.7-0.70.20.30.40.50.4
Glucose0.71.12.20.7-0.30.3-1.31.41.5-0.7-0.81.21.21.21.21.0
Heart weight0.30.51.30.70.3-0.3-1.11.00.9-0.0-0.20.80.70.50.60.8
Delay discount hyperbolic model param0.00.00.1-0.3-0.20.20.3-0.3-0.3-0.1-0.1-0.1-0.0-0.1-0.2-0.2
Intermittent access intake day 1-15 change0.20.91.60.5-0.30.3-1.21.11.2-0.6-0.71.31.11.01.11.1
Intermittent access intake escalation0.20.81.60.3-0.40.4-1.11.01.1-0.7-0.81.31.11.01.01.0
Intermittent access intake escalation 20.00.00.10.20.3-0.3-0.10.20.10.20.20.1-0.1-0.10.20.2
Intermitt. access day 1 inactive lever presses0.10.81.6-0.60.2-0.21.2-1.2-1.20.50.6-1.2-1.1-1.0-0.8-1.0
Intermitt. access day 15 inactive lever presses0.10.30.7-0.8-0.70.70.8-0.6-0.7-0.4-0.3-0.4-0.2-0.0-0.2-0.4
Intermitt. access escalation Index0.00.10.4-0.2-0.40.4-0.20.10.1-0.4-0.40.40.60.30.30.2
Intermittent access day 1 total infusions0.00.00.0-0.1-0.10.10.1-0.2-0.2-0.00.0-0.10.1-0.1-0.2-0.2
Intermittent access day 15 total infusions0.51.22.20.1-0.80.8-1.11.01.1-1.0-1.11.51.31.31.11.1
Intermittent access terminal intake (last 3 days)0.50.91.4-0.0-0.70.7-0.80.80.8-0.9-1.01.21.21.11.01.1
Intermittent access total infusions1.11.32.1-0.2-1.11.1-0.91.01.0-1.3-1.31.41.41.41.21.2
Intermittent access day 1 locomotion0.10.20.5-0.7-0.40.40.7-0.7-0.7-0.1-0.0-0.3-0.2-0.2-0.3-0.4
Intermittent access day 15 total locomotion0.10.20.5-0.0-0.40.4-0.50.40.5-0.5-0.50.70.70.60.50.5
Intermittent access total locomotion0.50.71.4-0.8-1.21.2-0.00.20.2-1.1-1.00.80.80.80.70.7
Intermittent access standard deviation0.00.20.4-0.6-0.70.70.1-0.2-0.0-0.6-0.50.30.40.40.20.4
Left kidney weight0.11.13.2-1.8-1.61.61.1-0.9-0.9-1.2-1.00.10.20.40.40.3
Right kidney weight0.10.51.6-1.3-1.11.10.8-0.8-0.8-0.7-0.6-0.10.10.10.10.0
Cocaine induced anxiety0.51.42.3-0.50.4-0.41.5-1.4-1.50.80.9-1.5-1.5-1.3-1.2-1.3
Post-drug Anxiety0.30.30.8-0.6-0.90.90.10.10.0-0.8-0.80.40.40.60.50.4
Baseline Anxiety1.83.04.70.1-1.31.3-1.71.81.7-1.7-1.82.12.22.01.71.9
Tail length0.31.86.2-2.5-1.71.72.0-1.7-1.7-1.0-0.7-0.6-0.5-0.20.1-0.0
Length with tail0.41.86.1-2.5-1.71.71.8-1.8-1.6-1.0-0.8-0.5-0.1-0.1-0.0-0.1
Length without tail0.21.03.3-1.8-1.21.21.2-1.5-1.3-0.8-0.6-0.40.2-0.1-0.3-0.2
Times rat made contact with spout0.60.71.2-0.1-0.70.7-0.70.80.8-0.9-0.91.11.11.00.91.0
Lifetime Intake0.70.91.5-0.1-0.90.9-0.80.80.8-1.0-1.11.11.21.20.91.0
Liver weight, left1.93.38.5-2.9-2.92.91.6-0.9-0.9-2.4-2.10.50.71.20.90.7
Liver weight, right1.73.07.2-2.2-2.72.70.7-0.1-0.1-2.4-2.21.01.21.61.41.2
Locomotor activity0.40.61.91.40.7-0.7-1.11.11.00.30.20.50.40.30.50.1
Locomotor testing distance0.10.20.80.90.7-0.7-0.50.50.50.40.30.20.1-0.00.2-0.1
Locomotor testing rearing0.00.00.10.20.2-0.2-0.20.00.20.00.00.20.20.10.40.1
Locomotion in novel chamber0.40.51.10.4-0.40.4-0.81.01.0-0.6-0.70.90.71.00.70.7
Locomotion in novel chamber post-restriction1.54.611.22.40.3-0.3-3.33.13.2-0.5-0.92.52.42.01.81.6
Fecal boli incidents, locomotor time 11.12.95.0-0.41.0-1.02.0-1.6-2.01.41.6-2.1-2.2-2.0-1.6-2.0
Change in fecal boli incidents, locomotor task3.23.44.90.0-1.51.5-1.71.81.8-1.8-2.02.22.22.22.02.1
Time >=10cm from walls, locomotor time 10.30.41.4-0.20.3-0.30.9-0.7-0.70.50.6-0.7-1.2-0.7-0.6-0.7
Bouts of movement, locomotor time 11.11.42.61.11.6-1.60.2-0.2-0.41.51.5-1.1-1.2-1.3-1.1-1.2
Total resting periods, locomotor time 10.70.92.01.31.4-1.4-0.30.30.11.21.1-0.6-0.6-0.8-0.7-0.8
Rest time, locomotor task time 10.00.10.20.40.2-0.2-0.40.40.10.10.10.20.2-0.10.20.0
Distance moved, locomotor task time 10.10.30.9-0.9-0.70.70.7-0.7-0.4-0.4-0.3-0.2-0.20.1-0.00.0
Vertical activity count, locomotor time 10.10.41.1-0.9-1.01.00.6-0.4-0.3-0.8-0.70.10.00.40.20.1
Time >=10cm from walls, locomotor time 20.51.52.7-0.60.4-0.41.6-1.4-1.60.80.9-1.5-1.6-1.4-1.1-1.4
Bouts of movement, locomotor time 21.13.75.60.82.2-2.21.0-1.4-1.32.32.4-2.0-2.2-2.3-2.0-2.0
Total resting periods, locomotor time 20.83.34.80.62.0-2.01.0-1.4-1.32.22.2-1.9-2.0-2.2-1.9-1.9
Rest time, locomotor task time 20.30.50.80.00.6-0.60.6-0.7-0.70.70.8-0.7-0.7-0.9-0.9-0.8
Distance moved, locomotor task time 20.40.51.6-1.3-0.80.81.0-0.8-0.9-0.5-0.3-0.5-0.3-0.10.1-0.0
Vertical activity count, locomotor time 20.61.43.9-2.0-1.81.81.3-0.9-1.0-1.4-1.20.00.10.40.60.4
Light reinforcement 10.31.52.40.91.5-1.50.4-0.5-0.81.51.5-1.1-1.3-1.5-1.3-1.4
Light reinforcement 20.20.40.70.40.7-0.70.2-0.2-0.50.80.8-0.7-0.6-0.8-0.6-0.8
Bone: marrow area0.61.53.4-1.2-0.20.21.9-1.7-1.80.40.6-1.3-1.4-1.2-1.2-1.1
Bone: maximum diameter0.50.92.1-1.0-0.20.21.4-1.4-1.50.30.4-1.0-1.0-0.9-0.9-0.8
Bone: maximum force0.10.20.40.30.4-0.40.2-0.2-0.30.50.5-0.3-0.4-0.5-0.6-0.5
Bone: maximum moment0.00.00.10.20.2-0.2-0.10.10.00.20.20.0-0.1-0.1-0.3-0.2
Mean time between licks in bursts0.00.20.5-0.7-0.60.60.4-0.3-0.3-0.4-0.4-0.10.10.20.40.2
Mean num. licks in bursts0.10.31.21.10.7-0.7-0.90.70.70.40.30.30.20.1-0.1-0.0
Cd content in liver0.20.20.5-0.7-0.30.30.7-0.7-0.7-0.00.1-0.5-0.2-0.4-0.3-0.2
Co content in liver2.83.34.80.61.9-1.91.0-1.4-1.42.12.2-2.1-2.0-2.2-2.1-1.9
Cu content in liver3.44.07.3-1.30.4-0.42.6-2.7-2.71.21.5-2.4-2.4-2.2-2.1-2.0
Fe content in liver0.20.30.5-0.00.3-0.30.5-0.5-0.50.50.5-0.6-0.7-0.6-0.5-0.6
K content in liver3.03.04.6-0.51.0-1.01.8-2.1-2.01.51.7-2.1-2.1-2.0-1.9-1.8
Mg content in liver3.43.75.4-0.21.3-1.31.8-2.1-2.11.82.0-2.3-2.2-2.3-2.3-2.2
Mn content in liver4.04.56.5-0.11.5-1.52.0-2.2-2.22.02.2-2.5-2.6-2.5-2.5-2.5
Na content in liver1.11.32.6-1.10.1-0.11.6-1.6-1.60.60.7-1.4-1.3-1.2-1.0-0.9
Rb content in liver1.31.62.7-0.00.7-0.71.3-1.2-1.41.11.2-1.4-1.6-1.4-1.5-1.7
Se content in liver3.13.76.8-1.20.3-0.32.5-2.6-2.61.11.3-2.3-2.2-2.1-2.1-2.1
Sr content in liver0.30.30.80.80.9-0.9-0.50.30.30.70.6-0.3-0.3-0.3-0.2-0.2
Zn content in liver2.83.24.80.92.0-2.00.8-1.2-1.22.22.2-1.8-1.8-2.1-2.1-2.0
Bone: minimum diameter0.81.65.5-2.4-1.81.81.7-1.4-1.4-1.1-0.9-0.3-0.20.10.00.1
Time in familiar zone, hab. session 10.70.71.30.3-0.40.4-0.91.11.1-0.7-0.81.00.81.01.01.0
Time in novel zone, hab. session 11.01.11.70.31.0-1.00.6-1.0-1.01.21.2-1.1-1.0-1.3-1.3-1.2
Total zone transitions, hab. session 11.11.53.00.81.4-1.40.4-0.7-0.71.51.5-1.1-1.2-1.3-1.7-1.4
Total locomotion distance, hab. session 11.82.66.2-1.9-0.50.52.4-2.5-2.50.30.6-1.6-1.4-1.5-1.7-1.3
Locomotion velocity, hab. session 12.02.86.7-2.3-0.80.82.6-2.5-2.50.00.3-1.6-1.4-1.3-1.5-1.2
Time in familiar zone, hab. session 20.20.30.70.70.8-0.8-0.30.10.10.70.6-0.1-0.3-0.4-0.5-0.4
Time in novel zone, hab. session 20.10.20.5-0.7-0.60.60.4-0.3-0.3-0.5-0.4-0.10.10.20.20.2
Total zone transitions, hab. session 20.60.81.61.31.3-1.3-0.40.20.21.21.1-0.4-0.5-0.7-0.9-0.7
Total locomotion distance, hab. session 21.01.33.2-1.5-0.60.61.8-1.8-1.70.10.3-1.1-1.0-0.9-1.1-0.8
Locomotion velocity, hab. session 21.41.94.0-1.3-0.20.22.0-2.0-2.00.50.7-1.5-1.4-1.4-1.5-1.3
Novel to familiar place preference ratio0.00.00.1-0.2-0.00.00.2-0.3-0.30.10.1-0.2-0.2-0.2-0.1-0.1
Novelty place preference0.10.10.2-0.00.2-0.20.3-0.4-0.40.40.4-0.4-0.4-0.4-0.3-0.3
Time in novel zone, NPP test0.10.10.20.40.4-0.4-0.1-0.0-0.00.40.4-0.2-0.2-0.3-0.2-0.2
Total zone transitions, NPP test0.40.62.01.40.8-0.8-1.21.11.10.50.30.50.30.2-0.10.1
Total locomotion distance, NPP test0.40.51.5-1.2-0.80.81.1-1.0-0.9-0.4-0.3-0.4-0.4-0.2-0.4-0.2
Locomotion velocity, NPP test0.60.82.4-1.5-0.90.91.4-1.3-1.2-0.4-0.3-0.6-0.5-0.3-0.5-0.3
Intraocular pressure0.50.92.21.40.5-0.5-1.51.51.50.0-0.11.00.70.70.60.5
Delta distance traveled before/after self-admin0.10.10.20.20.5-0.50.0-0.2-0.20.50.5-0.3-0.2-0.5-0.3-0.3
Delta ambulatory time before/after self-admin0.10.20.50.60.7-0.7-0.20.10.00.60.5-0.2-0.2-0.4-0.2-0.3
Parametrial fat weight1.43.35.0-0.7-2.02.0-1.11.21.3-2.2-2.22.02.22.21.91.9
Pavlov. Cond. lever latency0.30.40.6-0.10.4-0.40.6-0.8-0.70.60.6-0.7-0.7-0.7-0.8-0.7
Pavlov. Cond. magazine entry latency0.30.40.91.00.6-0.6-1.00.90.80.20.10.50.50.30.10.1
Pavlov. Cond. change in total contacts2.22.43.6-1.0-1.81.8-0.61.00.9-1.9-1.91.61.61.71.71.7
Pavlov. Cond. index score0.10.20.40.50.2-0.2-0.60.70.5-0.1-0.10.40.40.30.30.2
Pavlov. Cond. latency score0.10.10.20.1-0.10.1-0.30.40.3-0.2-0.30.40.40.30.30.3
Pavlov. Cond. lever contacts0.10.10.20.1-0.20.2-0.30.40.3-0.3-0.30.40.40.30.30.3
Pavlov. Cond. magazine entry number0.30.41.1-1.0-0.50.51.0-1.0-0.9-0.1-0.0-0.6-0.6-0.4-0.3-0.3
Pavlov. Cond. intertrial magazine entries0.70.82.2-1.3-1.51.50.5-0.2-0.2-1.2-1.10.40.50.70.70.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.50.0-0.0-0.80.90.7-0.2-0.30.60.60.50.40.4
Pavlov. Cond. response bias0.30.40.90.60.1-0.1-0.91.00.8-0.2-0.30.70.70.60.50.5
Pavlov. Cond. lever latency5.98.327.7-5.3-4.34.33.2-2.3-2.3-3.2-2.80.00.31.01.21.3
Pavlov. Cond. magazine entry latency1.82.57.02.61.4-1.4-2.52.32.20.60.41.31.10.70.80.6
Pavlov. Cond. change in total contacts1.74.214.03.73.1-3.1-2.31.71.62.32.00.0-0.2-0.8-0.8-0.9
Pavlov. Cond. index score3.55.418.64.33.4-3.4-2.82.12.02.52.10.2-0.1-0.7-0.7-0.9
Pavlov. Cond. latency score3.04.816.94.13.1-3.1-2.92.32.22.11.80.50.2-0.3-0.3-0.5
Pavlov. Cond. lever contacts5.17.525.35.04.0-4.0-3.12.32.33.02.60.0-0.2-0.9-1.1-1.2
Pavlov. Cond. magazine entry number3.03.913.4-3.7-2.52.52.9-2.5-2.4-1.5-1.2-0.9-0.6-0.2-0.3-0.0
Pavlov. Cond. intertrial magazine entries1.02.35.7-1.9-0.60.62.4-2.3-2.20.10.4-1.7-1.6-1.2-1.2-1.1
Pavlov. Cond. lever-magazine prob. diff.3.14.816.64.13.2-3.2-2.72.12.02.31.90.2-0.0-0.5-0.5-0.7
Pavlov. Cond. response bias5.77.925.85.14.2-4.2-3.02.12.13.22.8-0.1-0.4-1.1-1.2-1.4
Time in closed arm before self-admin0.10.20.40.40.7-0.7-0.0-0.10.10.50.5-0.3-0.3-0.3-0.2-0.2
Time in closed arm after self-admin0.10.10.30.30.2-0.20.20.10.10.20.2-0.2-0.6-0.0-0.1-0.3
Time in open arm before self-admin1.41.73.00.21.3-1.31.0-1.0-1.31.41.5-1.5-1.7-1.7-1.2-1.4
Time in open arm after self-admin0.00.00.1-0.1-0.10.1-0.2-0.0-0.1-0.0-0.10.00.4-0.00.00.1
Bone: periosteal estimation0.61.43.5-1.7-0.70.71.9-1.7-1.8-0.10.1-1.1-1.0-0.8-0.9-0.8
Bone: periosteal perimeter0.40.71.4-0.7-0.00.01.2-1.2-1.20.40.5-1.1-0.9-0.8-1.0-0.8
Bone: post-yield work0.20.30.6-0.1-0.50.5-0.40.50.4-0.6-0.60.80.70.60.50.6
Progressive ratio test 1 active lever presses0.20.30.7-0.7-0.80.8-0.1-0.10.1-0.7-0.70.50.80.60.40.6
Progressive ratio test 1 breakpoint0.20.40.8-0.7-0.90.9-0.1-0.10.1-0.8-0.80.50.80.60.40.6
Progressive ratio test 1 inactive lever presses0.10.30.8-0.9-0.70.70.7-0.8-0.7-0.4-0.3-0.4-0.1-0.1-0.3-0.3
Progressive ratio test 2 active lever presses1.11.52.3-0.4-1.31.3-0.81.00.9-1.4-1.51.41.51.51.11.3
Progressive ratio test 2 breakpoint1.21.52.3-0.3-1.31.3-0.91.01.0-1.4-1.41.41.51.51.11.3
Progressive ratio test 2 inactive lever presses0.31.11.80.3-0.70.7-1.11.11.1-1.0-1.01.31.31.31.01.0
Incentive Sensitization - Responses0.41.11.7-0.1-1.01.0-0.81.00.9-1.2-1.21.11.21.31.01.1
Incentive Sensitization - Breakpoint0.51.11.70.1-0.80.8-1.01.21.0-1.0-1.11.21.21.31.01.1
Sum of active levers in priming session hrs 5-60.50.51.20.7-0.10.1-1.00.90.8-0.3-0.41.10.90.60.40.6
Progressive ratio0.72.04.11.32.0-2.00.1-0.3-0.51.91.8-1.3-1.1-1.6-1.2-1.4
Food seeking constrained by brief footshock0.50.61.10.40.7-0.70.6-0.5-0.60.91.0-0.8-0.9-0.9-1.0-1.0
Seeking ratio, punishment vs. effort0.61.43.9-1.7-2.02.00.8-0.5-0.4-1.5-1.40.60.40.90.50.7
Retroperitoneal fat weight2.812.526.0-3.8-5.15.10.30.50.5-4.8-4.62.93.23.63.33.1
Reaction time number correct0.00.20.50.70.7-0.7-0.40.30.20.50.5-0.1-0.1-0.3-0.1-0.2
Reaction time mean minus median0.00.10.40.60.5-0.5-0.20.40.20.40.3-0.2-0.1-0.10.1-0.3
Reaction time mean minus median AUC0.00.10.20.40.3-0.3-0.20.40.20.20.2-0.1-0.0-0.00.2-0.1
Reaction time num false alarms1.11.96.5-2.6-1.81.82.0-1.6-1.5-1.2-1.0-0.5-0.40.10.10.2
Reaction time num false alarms AUC0.91.95.9-2.4-2.12.11.4-1.0-0.9-1.7-1.40.20.20.70.70.8
Reaction time trials correct on left0.00.20.50.70.7-0.7-0.40.30.20.50.5-0.1-0.1-0.3-0.1-0.2
Reaction time trials on left0.10.20.50.70.7-0.7-0.40.40.30.50.5-0.0-0.1-0.3-0.1-0.1
Reaction time mean0.10.10.30.20.4-0.40.2-0.1-0.30.50.5-0.4-0.3-0.5-0.4-0.5
Reaction time mean AUC0.00.00.1-0.00.1-0.10.2-0.0-0.30.10.1-0.3-0.1-0.2-0.1-0.3
Median of all reaction times0.10.10.20.20.4-0.40.2-0.1-0.30.40.4-0.4-0.3-0.5-0.5-0.5
Reaction time omissions0.20.40.60.1-0.40.4-0.60.80.6-0.6-0.60.70.80.60.80.7
Reaction time false alarm rate1.21.74.7-2.2-2.02.01.2-0.8-0.7-1.6-1.40.20.30.80.70.8
Reaction time premature initiation rate0.00.00.20.40.3-0.3-0.20.30.30.20.10.1-0.00.1-0.10.1
Reaction time premature initiations0.10.20.60.60.2-0.2-0.70.70.70.0-0.00.50.40.40.30.4
Std. dev. reaction times0.00.10.20.00.2-0.20.3-0.1-0.30.30.3-0.4-0.4-0.3-0.1-0.5
Reaction time trials completed0.10.20.50.70.7-0.7-0.40.40.30.50.5-0.0-0.1-0.3-0.1-0.1
Reaction time trials AUC0.00.20.40.60.6-0.6-0.30.30.20.50.5-0.1-0.1-0.3-0.1-0.2
Run reversals in cocaine runway, females0.20.20.4-0.30.2-0.20.6-0.6-0.60.30.3-0.6-0.6-0.5-0.5-0.5
Run reversals in cocaine runway, males2.32.55.61.5-0.10.1-2.42.22.3-0.6-0.81.91.91.61.41.5
Latency to leave start box in cocaine runway2.43.35.9-1.30.8-0.82.4-2.3-2.41.11.4-2.3-2.3-2.1-1.7-1.6
Latency to leave start box in cocaine runway, F4.55.79.0-0.81.6-1.62.6-2.7-2.72.02.2-3.0-3.0-2.9-2.3-2.3
Latency to leave start box in cocaine runway, M0.30.20.9-1.0-0.50.50.7-0.5-0.5-0.5-0.4-0.2-0.30.00.10.1
Std. dev. time between licks in bursts0.30.51.6-1.3-1.01.00.9-0.6-0.6-0.7-0.6-0.1-0.20.20.40.2
Total sessions with >9 infusions0.20.30.5-0.00.5-0.50.3-0.7-0.50.60.6-0.6-0.3-0.7-0.7-0.5
Short access day 1 total inactive lever presses0.71.42.8-0.9-1.71.7-0.20.40.5-1.6-1.61.01.11.40.91.0
Short access day 10 total inactive lever presses0.00.10.30.0-0.00.00.4-0.1-0.40.00.1-0.3-0.4-0.2-0.3-0.6
Short access day 1 total infusions0.20.40.8-0.4-0.90.9-0.30.20.3-0.8-0.80.70.90.80.50.6
Short access day 10 total infusions0.10.20.5-0.6-0.20.20.6-0.7-0.60.00.1-0.4-0.3-0.3-0.3-0.2
Short access total infusions0.00.00.1-0.2-0.10.1-0.0-0.2-0.1-0.1-0.10.10.30.0-0.10.1
Short access day 1 locomotion0.20.30.50.30.7-0.70.1-0.4-0.30.70.7-0.5-0.4-0.6-0.6-0.6
Short access day 10 total locomotion0.00.00.00.0-0.00.0-0.10.10.1-0.1-0.10.20.10.10.00.0
Short access total locomotion0.30.50.9-0.30.4-0.40.7-1.0-0.90.60.7-0.7-0.6-0.9-0.8-0.7
One hour access (0.3 mA shock)0.30.30.91.00.5-0.5-0.90.80.70.20.10.50.50.20.20.2
Compulsive drug intake0.00.00.10.20.1-0.1-0.30.20.10.0-0.00.10.30.0-0.0-0.0
One hour access (shock baseline)0.20.61.51.20.6-0.6-1.21.11.10.20.00.70.50.40.40.3
Social response proportion0.10.20.40.0-0.40.4-0.20.50.4-0.5-0.50.20.10.50.70.3
Social responses0.30.41.10.90.4-0.4-0.81.01.00.0-0.10.40.20.50.50.4
Social time0.30.41.3-1.1-0.70.71.1-0.8-0.9-0.4-0.3-0.5-0.6-0.2-0.2-0.1
Soleus weight0.30.82.1-1.5-1.01.01.4-1.3-1.3-0.3-0.2-0.6-0.6-0.4-0.2-0.3
Bone: stiffness0.00.10.2-0.4-0.40.40.2-0.1-0.2-0.3-0.30.10.20.10.10.1
Tibialis anterior weight0.10.20.50.50.7-0.7-0.1-0.1-0.20.60.6-0.2-0.2-0.5-0.4-0.5
Time to tail flick, vehicle, before self-admin0.30.30.91.00.9-0.9-0.70.40.40.60.50.20.1-0.30.00.0
Time to tail flick, vehicle, after self-admin0.10.20.50.70.7-0.7-0.30.20.20.50.5-0.2-0.1-0.3-0.4-0.3
Time to tail flick, test, before self-admin0.40.51.5-1.2-0.50.51.0-1.2-1.2-0.10.0-0.4-0.4-0.6-0.3-0.3
Time to tail flick, test, after self-admin2.52.74.3-0.60.9-0.92.0-1.9-2.01.31.5-1.8-2.1-2.0-1.6-1.8
Delta time to tail flick, vehicle, before/after SA0.20.20.40.50.6-0.60.00.00.00.60.5-0.6-0.4-0.4-0.5-0.5
Delta time to tail flick, test, before/after SA0.60.81.60.20.8-0.80.9-0.6-0.60.90.9-1.1-1.3-0.9-1.0-1.1
Tibia length1.54.15.9-0.41.2-1.22.1-2.3-2.31.82.0-2.3-2.4-2.4-2.4-2.3
Ambulatory time before self-admin0.20.51.0-0.4-1.01.0-0.20.50.5-1.0-1.00.70.61.00.60.7
Ambulatory time after self-admin0.00.00.00.1-0.10.1-0.00.20.1-0.1-0.10.10.00.1-0.00.0
Bone: tissue strength6.16.49.6-0.3-2.12.1-2.02.52.4-2.7-2.83.12.93.02.92.9
Total heroin consumption0.70.91.80.9-0.00.0-1.31.31.3-0.4-0.51.31.10.90.70.8
Bone: trabecular number0.40.81.2-0.4-0.90.9-0.40.60.6-1.0-1.00.90.91.01.11.0
Bone: trabecular spacing0.10.10.40.70.3-0.3-0.50.30.40.30.30.10.1-0.00.1-0.0
Bone: trabecular thickness0.20.31.0-1.0-0.70.70.5-0.4-0.4-0.7-0.60.10.20.20.10.3
Bone: trabecular tissue density1.62.84.6-0.60.8-0.81.9-2.0-1.91.31.4-2.1-2.0-1.8-2.0-1.8
Water consumed over 24 hours0.40.91.2-0.3-0.90.9-0.60.80.8-1.0-1.11.11.01.11.11.1
Number of responses in last shaping day1.62.15.0-1.3-0.10.12.2-2.0-2.00.60.8-1.5-1.8-1.4-1.4-1.5