Hub : Traits

Ambulatory time before self-admin

Ambulatary time in seconds at the first time point of open field before self admin

Tags: Behavior · Heroin · Open field test

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	33211184	34601262	1	1	5.00e-08	3.08e-01	2.69e-10	Ddx25
2	chr19	32676171	34074113	1	1	2.28e-09	3.59e-02	4.54e-01	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.62	1	0	0	0	1e+00	Ddx25
BMI without tail	4.08	1	0	0	0	1e+00	Ddx25
Epididymis fat weight	3.94	1	0	0	0	1e+00	Zdhhc1
Left kidney weight	12.42	1	1	50	0	1e+00	Zdhhc1
Right kidney weight	7.53	2	1	50	0	1e+00	Ddx25 Zdhhc1
Tail length	6.06	1	0	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	0	1e+00	Ddx25
Parametrial fat weight	6.14	2	0	0	0	1e+00	Ddx25 Zdhhc1
Retroperitoneal fat weight	2.69	1	0	0	0	1e+00	Zdhhc1
Intraocular pressure	4.47	1	0	0	0	1e+00	Zdhhc1
Patch foraging indifference point AUC	7.82	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 12 sec	3.95	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 18 sec	4.11	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 24 sec	6.8	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 6 sec	4.17	1	0	0	0	1e+00	Zdhhc1
Patch foraging water rate 18 sec	5.97	1	0	0	0	1e+00	Zdhhc1
Patch foraging water rate 6 sec	6.12	1	0	0	0	1e+00	Zdhhc1
Locomotor activity	6.51	2	0	0	0	1e+00	Ddx25 Zdhhc1
Locomotor testing distance	4.75	1	0	0	0	1e+00	Ddx25
Locomotor testing rearing	4.78	2	0	0	0	1e+00	Ddx25 Zdhhc1
Light reinforcement 1	9.77	1	0	0	0	1e+00	Zdhhc1
Light reinforcement 2	4.91	1	0	0	0	1e+00	Zdhhc1
Reaction time number correct	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time mean minus median AUC	5.33	2	0	0	0	1e+00	Ddx25 Zdhhc1
Reaction time trials correct on left	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time trials on left	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time mean	14.48	2	1	50	0	1e+00	Ddx25 Zdhhc1
Reaction time mean AUC	19.64	1	0	0	0	1e+00	Zdhhc1
Median of all reaction times	26.45	1	1	50	0	1e+00	Zdhhc1
Std. dev. reaction times	8.62	1	0	0	0	1e+00	Zdhhc1
Reaction time trials completed	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time trials AUC	6.44	1	0	0	0	1e+00	Zdhhc1
Social response proportion	10.93	1	0	0	0	1e+00	Zdhhc1
Conditioned locomotion	5.5	1	0	0	0	1e+00	Zdhhc1
Conditioned reinforcement - inactives	14.96	1	0	0	0	1e+00	Ddx25
Conditioned locomotion	6.11	1	0	0	0	1e+00	Zdhhc1
Intermittent access intake day 1-15 change	78.98	1	1	50	0	1e+00	Ddx25
Intermittent access intake escalation	41.26	1	1	50	0	1e+00	Ddx25
Intermittent access intake escalation 2	33.1	1	1	50	0	1e+00	Ddx25
Intermitt. access day 1 inactive lever presses	25.7	1	1	50	0	1e+00	Ddx25
Intermitt. access day 15 inactive lever presses	24.67	2	1	50	0	1e+00	Ddx25 Zdhhc1
Intermitt. access escalation Index	14.59	1	0	0	0	1e+00	Ddx25
Intermittent access day 1 total infusions	10.04	1	0	0	0	1e+00	Zdhhc1
Intermittent access day 15 total infusions	29.06	2	1	50	0	1e+00	Ddx25 Zdhhc1
Intermittent access terminal intake (last 3 days)	25.8	2	1	50	0	1e+00	Ddx25 Zdhhc1
Intermittent access total infusions	19.19	2	1	50	0	1e+00	Ddx25 Zdhhc1
Intermittent access standard deviation	15.54	1	0	0	0	1e+00	Ddx25
Cocaine induced anxiety	12.68	1	0	0	0	1e+00	Ddx25
Post-drug Anxiety	8.64	1	0	0	0	1e+00	Zdhhc1
Baseline Anxiety	5.61	1	0	0	0	1e+00	Ddx25
Lifetime Intake	27.93	2	1	50	0	1e+00	Ddx25 Zdhhc1
Incentive Sensitization - Responses	24.33	2	1	50	0	1e+00	Ddx25 Zdhhc1
Incentive Sensitization - Breakpoint	25.95	2	1	50	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 1 active lever presses	10.25	2	0	0	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 1 breakpoint	5.9	2	0	0	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 1 inactive lever presses	9.74	2	0	0	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 2 active lever presses	21.08	2	1	50	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 2 breakpoint	19.87	2	0	0	0	1e+00	Ddx25 Zdhhc1
Progressive ratio test 2 inactive lever presses	38.14	1	1	50	0	1e+00	Ddx25
Total sessions with >9 infusions	33.55	2	1	50	0	1e+00	Ddx25 Zdhhc1
Short access day 10 total inactive lever presses	8.25	1	0	0	0	1e+00	Zdhhc1
Short access day 1 total infusions	34.79	2	1	50	0	1e+00	Ddx25 Zdhhc1
Short access day 10 total infusions	20.18	2	1	50	0	1e+00	Ddx25 Zdhhc1
Short access total infusions	31.31	2	1	50	0	1e+00	Ddx25 Zdhhc1
Short access day 10 total locomotion	11.38	1	0	0	0	1e+00	Ddx25
One hour access (0.3 mA shock)	70.35	1	1	50	0	1e+00	Ddx25
One hour access (shock baseline)	27.52	2	1	50	0	1e+00	Ddx25 Zdhhc1
Number of responses in last shaping day	22.17	2	1	50	0	1e+00	Ddx25 Zdhhc1
Bone surface	3.9	1	0	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1e+00	Zdhhc1
Bone: cortical area	7.52	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	0	1e+00	Ddx25
Bone: trabecular number	3.43	1	0	0	0	1e+00	Zdhhc1
Bone: trabecular thickness	4.3	1	0	0	0	1e+00	Ddx25
Distance traveled before self-admin	33.29	2	1	50	0	1e+00	Ddx25 Zdhhc1
Distance traveled after self-admin	12.05	1	0	0	0	1e+00	Ddx25
Delta time in closed arm before/after self-admin	6.42	1	0	0	0	1e+00	Ddx25
Delta time in open arm before/after self-admin	13.01	1	0	0	0	1e+00	Zdhhc1
Extinction: sum of active levers before priming	14.97	2	0	0	0	1e+00	Ddx25 Zdhhc1
Active lever presses in extinction session 6	9.76	2	0	0	0	1e+00	Ddx25 Zdhhc1
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	15.51	2	0	0	0	1e+00	Ddx25 Zdhhc1
Time in closed arm before self-admin	12.8	1	0	0	0	1e+00	Zdhhc1
Time in closed arm after self-admin	7.24	1	0	0	0	1e+00	Zdhhc1
Time to tail flick, vehicle, before self-admin	14.06	2	0	0	0	1e+00	Ddx25 Zdhhc1
Time to tail flick, test, before self-admin	5.88	1	0	0	0	1e+00	Ddx25
Time to tail flick, test, after self-admin	5.3	1	0	0	0	1e+00	Zdhhc1
Ambulatory time after self-admin	5.62	1	0	0	0	1e+00	Ddx25
Total heroin consumption	8.9	1	0	0	0	1e+00	Ddx25
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1e+00	Zdhhc1
Time >=10cm from walls, locomotor time 1	16	1	0	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 1	5.83	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 1	5.4	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	4.87	1	0	0	0	1e+00	Zdhhc1
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 2	15.61	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 2	17.95	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 2	11.34	1	0	0	0	1e+00	Zdhhc1
Progressive ratio	22.47	1	0	0	0	1e+00	Zdhhc1
Seeking ratio, punishment vs. effort	9.83	1	0	0	0	1e+00	Zdhhc1
Run reversals in cocaine runway, males	8.37	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, F	9.76	1	0	0	0	1e+00	Zdhhc1
Latency to leave start box in cocaine runway, M	26.41	2	1	50	0	1e+00	Ddx25 Zdhhc1
Sr content in liver	9.74	1	0	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.02
Adipose	alternative TSS	0	0	0.96
Adipose	gene expression	1	0	1.01
Adipose	isoform ratio	0	0	1.01
Adipose	intron excision ratio	0	0	0.93
Adipose	mRNA stability	0	0	1.06
BLA	alternative polyA	0	0	1.13
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.03
BLA	intron excision ratio	0	0	1.02
BLA	mRNA stability	0	0	1
Brain	alternative polyA	0	0	1.09
Brain	alternative TSS	0	0	1.04
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.02
Brain	intron excision ratio	0	0	1
Brain	mRNA stability	0	0	1.04
Eye	alternative polyA	0	0	1.15
Eye	alternative TSS	0	0	0.95
Eye	gene expression	0	0	1
Eye	isoform ratio	0	0	1.03
Eye	intron excision ratio	0	0	1.07
Eye	mRNA stability	0	0	1.05
IL	alternative polyA	0	0	1.07
IL	alternative TSS	0	0	1.01
IL	gene expression	0	0	1.05
IL	isoform ratio	0	0	1
IL	intron excision ratio	0	0	0.96
IL	mRNA stability	0	0	1.05
LHb	alternative polyA	0	0	1.16
LHb	alternative TSS	0	0	1.16
LHb	gene expression	0	0	1.03
LHb	isoform ratio	0	0	1.06
LHb	intron excision ratio	0	0	0.99
LHb	mRNA stability	0	0	1.06
Liver	alternative polyA	0	0	1.06
Liver	alternative TSS	0	0	1
Liver	gene expression	0	0	1.05
Liver	isoform ratio	0	0	1.04
Liver	intron excision ratio	0	0	1.09
Liver	mRNA stability	0	0	1.06
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1.09
NAcc	gene expression	0	0	1.06
NAcc	isoform ratio	0	0	1.07
NAcc	intron excision ratio	0	0	1.02
NAcc	mRNA stability	1	0	1.04
OFC	alternative polyA	0	0	1.12
OFC	alternative TSS	0	0	1.11
OFC	gene expression	0	0	1.02
OFC	isoform ratio	0	0	1.05
OFC	intron excision ratio	0	0	0.95
OFC	mRNA stability	0	0	1.08
PL	alternative polyA	0	0	1.09
PL	alternative TSS	0	0	1.05
PL	gene expression	0	0	1.04
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1.05
PL	mRNA stability	0	0	1.03
pVTA	alternative polyA	0	0	1.14
pVTA	alternative TSS	0	0	0.97
pVTA	gene expression	0	0	1.05
pVTA	isoform ratio	0	0	1.08
pVTA	intron excision ratio	0	0	1.03
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	0	0	1.09
RMTg	alternative TSS	0	0	0.97
RMTg	gene expression	0	0	1.05
RMTg	isoform ratio	0	0	1.08
RMTg	intron excision ratio	0	0	0.95
RMTg	mRNA stability	0	0	1.06