Hub : Traits

Ambulatory time before self-admin

Ambulatary time in seconds at the first time point of open field before self admin

Tags: Behavior · Heroin · Open field test

Project: u01_peter_kalivas

6 loci · 6 genes with independent associations · 7 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	89562573	90958818	1	1	4.62e-10	1.80e-01	1.44e-56	Serping1
2	chr5	118282290	119677504	1	1	6.66e-09	5.70e-01	1.09e-41	Atg4c
3	chr8	41432021	42517271	1	1	1.23e-10	4.48e-02	1.08e-08	Foxred1
4	chr9	83390749	84777604	2	1	0.00e+00	6.82e-01	1.00e+00	Retreg2
5	chr10	13551895	14951178	1	1	8.73e-09	2.98e-04	6.28e-02	Rnf151
6	chr17	61510864	62906219	1	1	2.47e-45	1.62e-01	1.88e-43	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1920.83	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
BMI without tail	48016.73	2	2	33.3	0	1.00e+00	Ccny Retreg2
Body weight	3.91	1	0	0	0	1.00e+00	Retreg2
Epididymis fat weight	36173.48	2	2	33.3	0	1.00e+00	Ccny Retreg2
Glucose	795.14	3	1	16.7	0	1.00e+00	Atg4c Retreg2 Rnf151
Heart weight	4512.27	3	2	33.3	0	1.00e+00	Ccny Retreg2 Serping1
Left kidney weight	35319.15	3	1	16.7	-1	1.60e-04	Ccny Foxred1 Retreg2
Right kidney weight	29218.45	3	2	33.3	-1	5.59e-05	Ccny Foxred1 Retreg2
Tail length	23038.48	3	2	33.3	1	5.00e-05	Ccny Retreg2 Serping1
Length with tail	2048.48	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Length without tail	43114.79	2	2	33.3	0	1.00e+00	Ccny Retreg2
Liver weight, left	7265.45	2	2	33.3	0	1.00e+00	Ccny Retreg2
Liver weight, right	129.69	2	1	16.7	0	1.00e+00	Ccny Retreg2
Parametrial fat weight	209.08	3	1	16.7	0	1.00e+00	Ccny Foxred1 Retreg2
Retroperitoneal fat weight	5356.91	2	2	33.3	0	1.00e+00	Atg4c Retreg2
Intraocular pressure	20040.92	1	1	16.7	0	1.00e+00	Retreg2
Extensor digitorum longus weight	4682.69	1	1	16.7	0	1.00e+00	Retreg2
Soleus weight	59.13	2	1	16.7	0	1.00e+00	Ccny Retreg2
Tibialis anterior weight	4881.94	1	1	16.7	0	1.00e+00	Retreg2
Tibia length	3259.43	1	1	16.7	0	1.00e+00	Retreg2
Number of licking bursts	39285.03	3	1	16.7	1	7.78e-05	Ccny Retreg2 Serping1
Food consumed during 24 hour testing period	26555.4	3	1	16.7	-1	4.18e-04	Ccny Retreg2 Rnf151
Times rat made contact with spout	155.92	2	1	16.7	0	1.00e+00	Retreg2 Rnf151
Mean time between licks in bursts	66505.9	2	1	16.7	0	1.00e+00	Ccny Retreg2
Mean num. licks in bursts	35655.63	3	1	16.7	-1	6.87e-05	Ccny Retreg2 Serping1
Std. dev. time between licks in bursts	47023.26	1	1	16.7	0	1.00e+00	Retreg2
Water consumed over 24 hours	34477.35	2	1	16.7	0	1.00e+00	Ccny Retreg2
Patch foraging indifference point 0 sec	57503.47	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Patch foraging indifference point AUC	44400.63	2	2	33.3	0	1.00e+00	Ccny Retreg2
Indifference point function ln k	47362.28	2	2	33.3	0	1.00e+00	Ccny Retreg2
Indifference point function log k	47362.28	2	2	33.3	0	1.00e+00	Ccny Retreg2
Patch foraging total patch changes 0 sec	40090.28	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Patch foraging total patch changes 12 sec	2756.76	4	2	33.3	1	1.83e-03	Atg4c Ccny Foxred1 Retreg2
Patch foraging total patch changes 18 sec	29446	3	1	16.7	1	3.35e-05	Atg4c Ccny Retreg2
Patch foraging total patch changes 24 sec	55706.51	2	2	33.3	0	1.00e+00	Ccny Retreg2
Patch foraging total patch changes 6 sec	10903.88	3	2	33.3	0	1.00e+00	Atg4c Ccny Retreg2
Patch foraging time to switch 0 sec	78317.03	1	1	16.7	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	74409.78	1	1	16.7	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	53974.31	2	2	33.3	0	1.00e+00	Ccny Retreg2
Patch foraging water rate 18 sec	34430.86	2	1	16.7	0	1.00e+00	Ccny Retreg2
Patch foraging water rate 24 sec	2357.13	2	2	33.3	0	1.00e+00	Ccny Retreg2
Patch foraging water rate 6 sec	2028.63	2	2	33.3	0	1.00e+00	Ccny Retreg2
Locomotor activity	26.33	3	1	16.7	0	1.00e+00	Ccny Foxred1 Retreg2
Locomotor testing distance	22395.94	3	2	33.3	-1	1.46e-03	Ccny Foxred1 Retreg2
Locomotor testing rearing	50814.92	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Light reinforcement 1	31072.63	4	2	33.3	-1	2.52e-06	Atg4c Ccny Retreg2 Serping1
Light reinforcement 2	36018.13	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time number correct	51169.82	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time mean minus median	68610.76	2	1	16.7	0	1.00e+00	Ccny Retreg2
Reaction time mean minus median AUC	104208.6	1	1	16.7	0	1.00e+00	Retreg2
Reaction time num false alarms	28557.11	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time num false alarms AUC	35512.89	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time trials correct on left	51169.82	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time trials on left	50015.01	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time mean	23601.36	3	1	16.7	1	3.01e-04	Atg4c Ccny Retreg2
Reaction time mean AUC	28341.95	3	1	16.7	1	2.96e-04	Atg4c Ccny Retreg2
Median of all reaction times	10477.75	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Reaction time omissions	17136.41	1	1	16.7	0	1.00e+00	Retreg2
Reaction time false alarm rate	891.26	1	1	16.7	0	1.00e+00	Retreg2
Reaction time premature initiation rate	18442.81	2	1	16.7	0	1.00e+00	Ccny Retreg2
Reaction time premature initiations	46245.52	2	1	16.7	0	1.00e+00	Ccny Retreg2
Std. dev. reaction times	74752.64	1	1	16.7	0	1.00e+00	Retreg2
Reaction time trials completed	50015.01	2	2	33.3	0	1.00e+00	Ccny Retreg2
Reaction time trials AUC	50583.83	2	2	33.3	0	1.00e+00	Ccny Retreg2
Social response proportion	17659.31	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Social responses	1908.48	3	2	33.3	0	1.00e+00	Ccny Retreg2 Serping1
Social time	14749.31	3	1	16.7	0	1.00e+00	Ccny Retreg2 Serping1
Conditioned locomotion	3044.63	2	1	16.7	0	1.00e+00	Ccny Retreg2
Cocaine response after cond. corrected	16463.61	3	1	16.7	1	5.99e-04	Atg4c Ccny Retreg2
Cocaine response after cond. not corrected	16069.67	3	1	16.7	1	4.62e-04	Atg4c Ccny Retreg2
Cocaine response before conditioning	1409.02	2	1	16.7	0	1.00e+00	Ccny Retreg2
Saline control response	6484.47	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	53410.48	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	91582.24	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active responses	9691.24	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	21056.03	2	1	16.7	0	1.00e+00	Ccny Retreg2
Condit. Reinf. lever presses	15873.43	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. lever reinforcers received	2000.77	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	10912.53	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	24714.14	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. change in total contacts	57394.24	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. index score	23998.4	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. latency score	29242.48	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever contacts	22069.78	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	8389.95	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. intertrial magazine entries	52471.02	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	22438.69	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. response bias	5169.79	1	1	16.7	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	63840.11	2	2	33.3	0	1.00e+00	Ccny Retreg2
Conditioned reinforcement - inactives	31017.02	4	3	50	1	2.22e-05	Atg4c Ccny Foxred1 Retreg2
Conditioned locomotion	13824.85	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Intermittent access intake day 1-15 change	42128.5	4	3	50	1	8.13e-06	Atg4c Ccny Foxred1 Retreg2
Intermittent access intake escalation	52397.46	3	2	33.3	1	3.66e-04	Atg4c Foxred1 Retreg2
Intermittent access intake escalation 2	36059.12	3	3	50	0	1.00e+00	Ccny Foxred1 Retreg2
Intermitt. access day 1 inactive lever presses	78854.06	2	1	16.7	0	1.00e+00	Ccny Retreg2
Intermitt. access day 15 inactive lever presses	69426.27	2	2	33.3	0	1.00e+00	Foxred1 Retreg2
Intermitt. access escalation Index	61671.96	2	1	16.7	0	1.00e+00	Ccny Retreg2
Intermittent access day 1 total infusions	31110.92	4	1	16.7	-1	6.98e-06	Atg4c Ccny Foxred1 Retreg2
Intermittent access day 15 total infusions	32884.42	3	2	33.3	1	4.66e-04	Ccny Foxred1 Retreg2
Intermittent access terminal intake (last 3 days)	27748.25	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Intermittent access total infusions	234.73	3	1	16.7	0	1.00e+00	Ccny Foxred1 Retreg2
Intermittent access day 1 locomotion	26127.93	3	2	33.3	-1	1.03e-03	Ccny Foxred1 Retreg2
Intermittent access day 15 total locomotion	44477.15	3	2	33.3	1	4.18e-05	Atg4c Ccny Retreg2
Intermittent access total locomotion	711.59	1	1	16.7	0	1.00e+00	Retreg2
Intermittent access standard deviation	50494.04	3	2	33.3	1	8.15e-04	Ccny Foxred1 Retreg2
Cocaine induced anxiety	40081.45	3	2	33.3	-1	4.73e-05	Ccny Foxred1 Retreg2
Post-drug Anxiety	10234.13	1	1	16.7	0	1.00e+00	Retreg2
Baseline Anxiety	25888.27	3	2	33.3	1	1.61e-05	Ccny Foxred1 Retreg2
Lifetime Intake	2296.41	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Incentive Sensitization - Responses	40906.86	3	3	50	-1	5.10e-05	Atg4c Ccny Retreg2
Incentive Sensitization - Breakpoint	28569.44	4	3	50	-1	5.38e-07	Atg4c Ccny Foxred1 Retreg2
Progressive ratio test 1 active lever presses	33314.25	2	2	33.3	0	1.00e+00	Ccny Retreg2
Progressive ratio test 1 breakpoint	32104.18	2	2	33.3	0	1.00e+00	Ccny Retreg2
Progressive ratio test 1 inactive lever presses	30227.71	4	2	33.3	1	1.81e-05	Atg4c Ccny Foxred1 Retreg2
Progressive ratio test 2 active lever presses	14320.73	3	2	33.3	-1	1.28e-05	Atg4c Ccny Retreg2
Progressive ratio test 2 breakpoint	8764.12	3	2	33.3	-1	1.25e-04	Atg4c Ccny Retreg2
Progressive ratio test 2 inactive lever presses	32828.63	4	2	33.3	1	2.09e-05	Ccny Foxred1 Retreg2 Rnf151
Total sessions with >9 infusions	2684.86	3	2	33.3	0	1.00e+00	Atg4c Ccny Retreg2
Short access day 1 total inactive lever presses	28606.45	3	2	33.3	-1	8.09e-04	Ccny Foxred1 Retreg2
Short access day 10 total inactive lever presses	72422.55	2	2	33.3	0	1.00e+00	Ccny Retreg2
Short access day 1 total infusions	27935.77	3	2	33.3	-1	3.22e-04	Ccny Foxred1 Retreg2
Short access day 10 total infusions	19077.47	3	1	16.7	-1	6.67e-05	Atg4c Ccny Retreg2
Short access total infusions	17026.24	2	2	33.3	0	1.00e+00	Ccny Retreg2
Short access day 1 locomotion	21032.66	3	2	33.3	1	8.24e-04	Ccny Foxred1 Retreg2
Short access day 10 total locomotion	45410.93	3	3	50	1	3.20e-04	Ccny Foxred1 Retreg2
Short access total locomotion	22766.87	2	2	33.3	0	1.00e+00	Foxred1 Retreg2
Compulsive drug intake	16369.35	3	2	33.3	-1	3.74e-04	Ccny Foxred1 Retreg2
One hour access (0.3 mA shock)	3259.74	3	3	50	0	1.00e+00	Ccny Foxred1 Retreg2
One hour access (shock baseline)	35072.97	3	1	16.7	1	2.77e-04	Ccny Foxred1 Retreg2
Number of responses in last shaping day	12857.48	3	2	33.3	1	2.27e-04	Ccny Foxred1 Retreg2
Context. condit. distance diff. score	970.59	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 1	14615.25	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 1	2213.01	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	4683.52	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Locomotion distance, session 2	1206.44	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 3	2332.53	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	5866.4	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	12131.92	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 7	1310.17	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 7	3744.54	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 7	10466.92	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	8847.36	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 8	950.4	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion distance, session 8	673.32	1	1	16.7	0	1.00e+00	Retreg2
Degree of sensitization distance	15309.16	1	1	16.7	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	8496.38	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	1382.49	3	1	16.7	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. active-inactive response ratio	555.67	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Condit. Reinf. active responses	3898.02	3	1	16.7	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. inactive responses	19375.3	1	1	16.7	0	1.00e+00	Retreg2
Incentive salience index mean	4935.93	3	1	16.7	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. lever presses	21433.81	1	1	16.7	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	20942.04	1	1	16.7	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	11846.13	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 1	1818.53	1	1	16.7	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	849.35	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 1	571.33	2	1	16.7	0	1.00e+00	Ccny Retreg2
Time in familiar zone, hab. session 2	11692.92	1	1	16.7	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	8313.4	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 2	280.53	1	1	16.7	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 2	51.92	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 2	77.91	2	1	16.7	0	1.00e+00	Ccny Retreg2
Novel to familiar place preference ratio	13883.42	3	1	16.7	1	1.51e-04	Atg4c Ccny Retreg2
Novelty place preference	18134.07	3	1	16.7	0	1.00e+00	Atg4c Ccny Retreg2
Time in novel zone, NPP test	20429.42	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Total zone transitions, NPP test	8230.03	1	1	16.7	0	1.00e+00	Retreg2
Total locomotion distance, NPP test	3566.83	2	2	33.3	0	1.00e+00	Ccny Retreg2
Locomotion velocity, NPP test	2031.76	2	2	33.3	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	1101.84	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. magazine entry latency	8.04	1	0	0	0	1.00e+00	Ccny
Pavlov. Cond. change in total contacts	2273.55	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. index score	888.06	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. latency score	1841.19	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	1519.97	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. magazine entry number	1086.53	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. intertrial magazine entries	524.02	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	973.09	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. response bias	1308.04	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Bone: apparent density	22268.03	1	1	16.7	0	1.00e+00	Retreg2
Bone surface	25125.6	1	1	16.7	0	1.00e+00	Retreg2
Bone volume	33831.7	1	1	16.7	0	1.00e+00	Retreg2
Bone: connectivity density	7098.55	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical apparent density	22635.68	2	1	16.7	0	1.00e+00	Ccny Retreg2
Bone: cortical area	18930.98	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical porosity	1837.29	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical porosity	4807.78	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical thickness	1627.26	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical thickness	12190.6	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical tissue density	24229.43	2	1	16.7	0	1.00e+00	Ccny Retreg2
Bone: elastic displacement	14817.48	1	1	16.7	0	1.00e+00	Retreg2
Bone: elastic work	1494.59	1	1	16.7	0	1.00e+00	Retreg2
Bone: endosteal estimation	35257.61	1	1	16.7	0	1.00e+00	Retreg2
Bone: endosteal perimeter	22350.62	1	1	16.7	0	1.00e+00	Retreg2
Bone: final force	7031.22	1	1	16.7	0	1.00e+00	Retreg2
Bone: final moment	1042.62	1	1	16.7	0	1.00e+00	Retreg2
Bone: marrow area	37067.95	1	1	16.7	0	1.00e+00	Retreg2
Bone: maximum diameter	24401.62	1	1	16.7	0	1.00e+00	Retreg2
Bone: maximum force	34553.99	1	1	16.7	0	1.00e+00	Retreg2
Bone: maximum moment	24715.64	1	1	16.7	0	1.00e+00	Retreg2
Bone: minimum diameter	17196.64	1	1	16.7	0	1.00e+00	Retreg2
Bone: periosteal estimation	38190.5	1	1	16.7	0	1.00e+00	Retreg2
Bone: periosteal perimeter	43183.28	1	1	16.7	0	1.00e+00	Retreg2
Bone: post-yield work	50847.58	1	1	16.7	0	1.00e+00	Retreg2
Bone: stiffness	35564.91	1	1	16.7	0	1.00e+00	Retreg2
Bone: tissue strength	12264.67	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular number	41138.39	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular spacing	31287.85	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular thickness	33264.33	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular tissue density	26819.29	2	2	33.3	0	1.00e+00	Ccny Retreg2
Breakpoint value in progressive ratio session	37484.23	2	1	16.7	0	1.00e+00	Ccny Retreg2
Distance traveled before self-admin	19162.99	6	4	66.7	1	1.65e-12	Atg4c Ccny Foxred1 Retreg2 Rnf151 Serping1
Distance traveled after self-admin	20200.34	5	3	50	1	2.02e-06	Atg4c Ccny Foxred1 Retreg2 Rnf151
Delta time in closed arm before/after self-admin	527.63	4	2	33.3	0.86	1.38e-01	Atg4c Ccny Foxred1 Retreg2
Delta time in open arm before/after self-admin	13728.65	3	2	33.3	1	1.80e-03	Atg4c Ccny Retreg2
Diff in mean of infusions in LGA sessions	36174.27	2	2	33.3	0	1.00e+00	Atg4c Retreg2
Extinction: sum of active levers before priming	22945.82	3	3	50	1	2.94e-04	Ccny Foxred1 Retreg2
Active lever presses in extinction session 6	1120.26	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Delta distance traveled before/after self-admin	2523.18	4	2	33.3	-1	2.32e-04	Ccny Foxred1 Retreg2 Serping1
Delta ambulatory time before/after self-admin	16027.25	5	3	50	-1	7.59e-08	Atg4c Ccny Foxred1 Retreg2 Serping1
Time in closed arm before self-admin	14718.71	5	2	33.3	-1	3.94e-07	Atg4c Ccny Foxred1 Retreg2 Serping1
Time in closed arm after self-admin	9901.19	2	2	33.3	0	1.00e+00	Ccny Retreg2
Time in open arm before self-admin	6954.95	4	2	33.3	-1	3.35e-04	Atg4c Ccny Retreg2 Serping1
Time in open arm after self-admin	657.22	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Sum of active levers in priming session hrs 5-6	1298.28	3	1	16.7	0	1.00e+00	Retreg2 Rnf151 Serping1
Time to tail flick, vehicle, before self-admin	12969.27	3	2	33.3	1	2.10e-03	Ccny Foxred1 Retreg2
Time to tail flick, vehicle, after self-admin	23682.16	4	3	50	1	4.27e-05	Ccny Foxred1 Retreg2 Serping1
Time to tail flick, test, before self-admin	8210.35	4	1	16.7	-1	4.04e-04	Atg4c Ccny Foxred1 Retreg2
Time to tail flick, test, after self-admin	1999.21	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Delta time to tail flick, vehicle, before/after SA	9238.07	3	3	50	0.99	8.51e-03	Ccny Retreg2 Serping1
Delta time to tail flick, test, before/after SA	28423.85	2	1	16.7	0	1.00e+00	Ccny Retreg2
Ambulatory time after self-admin	22092.11	4	3	50	1	1.11e-04	Atg4c Ccny Retreg2 Rnf151
Total heroin consumption	284.11	4	3	50	0.91	8.95e-02	Atg4c Ccny Foxred1 Retreg2
Area under the delay curve	20413.22	3	2	33.3	-1	4.56e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 0s delay	9477.47	1	1	16.7	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	18726.93	3	3	50	-1	8.53e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 2s delay	282.83	3	1	16.7	0	1.00e+00	Atg4c Ccny Retreg2
Delay disc. indifference point, 24s delay	25014.94	3	2	33.3	-1	6.53e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 4s delay	876.78	3	3	50	0	1.00e+00	Atg4c Ccny Retreg2
Delay disc. indifference point, 8s delay	33815.67	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Delay discount exponential model param	20083.03	2	2	33.3	0	1.00e+00	Atg4c Retreg2
Delay discount hyperbolic model param	15250.3	2	2	33.3	0	1.00e+00	Atg4c Retreg2
Fecal boli incidents, locomotor time 1	37546.11	3	1	16.7	-1	4.60e-05	Atg4c Ccny Retreg2
Change in fecal boli incidents, locomotor task	11821.21	2	2	33.3	0	1.00e+00	Ccny Retreg2
Time >=10cm from walls, locomotor time 1	9867	4	2	33.3	-1	4.19e-05	Atg4c Ccny Retreg2 Serping1
Bouts of movement, locomotor time 1	20842.46	2	2	33.3	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 1	5936.78	2	2	33.3	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	18995.43	3	1	16.7	1	1.25e-04	Ccny Retreg2 Serping1
Distance moved, locomotor task time 1	39831.92	3	3	50	-1	8.89e-05	Ccny Retreg2 Serping1
Vertical activity count, locomotor time 1	73028.36	2	2	33.3	0	1.00e+00	Retreg2 Serping1
Time >=10cm from walls, locomotor time 2	40501.05	3	1	16.7	1	5.66e-05	Ccny Retreg2 Serping1
Bouts of movement, locomotor time 2	34870.01	4	2	33.3	1	2.29e-05	Ccny Foxred1 Retreg2 Serping1
Total resting periods, locomotor time 2	38024.8	4	2	33.3	1	1.85e-05	Ccny Foxred1 Retreg2 Serping1
Rest time, locomotor task time 2	20953.5	3	2	33.3	-1	4.44e-04	Atg4c Ccny Retreg2
Distance moved, locomotor task time 2	11481.53	3	2	33.3	0	1.00e+00	Atg4c Ccny Retreg2
Vertical activity count, locomotor time 2	27699.04	4	2	33.3	-1	1.19e-06	Atg4c Ccny Retreg2 Serping1
Weight adjusted by age	40516.27	3	2	33.3	1	7.66e-05	Ccny Retreg2 Rnf151
Seeking ratio, delayed vs. immediate footshock	24709.08	2	2	33.3	0	1.00e+00	Ccny Retreg2
Locomotion in novel chamber	8161.06	2	2	33.3	0	1.00e+00	Ccny Retreg2
Locomotion in novel chamber post-restriction	51552.82	2	1	16.7	0	1.00e+00	Ccny Retreg2
Progressive ratio	39490.25	3	2	33.3	-1	6.12e-05	Ccny Retreg2 Serping1
Food seeking constrained by brief footshock	3673.85	2	1	16.7	0	1.00e+00	Atg4c Retreg2
Seeking ratio, punishment vs. effort	39433.67	2	2	33.3	0	1.00e+00	Ccny Retreg2
Run reversals in cocaine runway, females	9305.2	4	1	16.7	-1	3.83e-04	Ccny Foxred1 Retreg2 Serping1
Run reversals in cocaine runway, males	7476.43	3	1	16.7	1	2.07e-03	Ccny Foxred1 Retreg2
Latency to leave start box in cocaine runway	29317.55	2	2	33.3	0	1.00e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	28379.24	1	1	16.7	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	1843.04	4	2	33.3	-0.99	1.18e-02	Ccny Foxred1 Retreg2 Serping1
Co content in liver	4721.74	1	1	16.7	0	1.00e+00	Retreg2
Cu content in liver	162.43	1	1	16.7	0	1.00e+00	Retreg2
Fe content in liver	5656.2	1	1	16.7	0	1.00e+00	Retreg2
K content in liver	6593.53	1	1	16.7	0	1.00e+00	Retreg2
Mg content in liver	24493.99	1	1	16.7	0	1.00e+00	Retreg2
Mn content in liver	4374.36	1	1	16.7	0	1.00e+00	Retreg2
Na content in liver	16641.94	1	1	16.7	0	1.00e+00	Retreg2
Rb content in liver	428.45	1	1	16.7	0	1.00e+00	Retreg2
Zn content in liver	15755.62	1	1	16.7	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.04
Adipose	alternative TSS	0	0	0.95
Adipose	gene expression	0	0	1.02
Adipose	isoform ratio	0	0	0.96
Adipose	intron excision ratio	0	0	0.91
Adipose	mRNA stability	1	0	1.04
BLA	alternative polyA	0	0	1.06
BLA	alternative TSS	0	0	1.03
BLA	gene expression	0	0	1.02
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.04
BLA	mRNA stability	0	0	1.01
Brain	alternative polyA	0	0	1.05
Brain	alternative TSS	0	0	1
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.03
Brain	intron excision ratio	0	0	1
Brain	mRNA stability	0	0	1.03
Eye	alternative polyA	0	0	0.93
Eye	alternative TSS	0	0	0.9
Eye	gene expression	0	0	1.05
Eye	isoform ratio	0	0	1.04
Eye	intron excision ratio	0	0	0.99
Eye	mRNA stability	0	0	0.97
IC	alternative polyA	0	0	1.02
IC	alternative TSS	0	0	0.96
IC	gene expression	0	0	1.04
IC	isoform ratio	0	0	1.07
IC	intron excision ratio	1	0	1.08
IC	mRNA stability	0	0	1.03
IL	alternative polyA	0	0	1.1
IL	alternative TSS	0	0	1.18
IL	gene expression	0	0	1.04
IL	isoform ratio	0	0	1.1
IL	intron excision ratio	0	0	1.18
IL	mRNA stability	0	0	1.03
LHb	alternative polyA	0	0	1.1
LHb	alternative TSS	0	0	1.19
LHb	gene expression	0	0	1.02
LHb	isoform ratio	0	0	1.12
LHb	intron excision ratio	0	0	1.03
LHb	mRNA stability	0	0	1.02
Liver	alternative polyA	0	0	0.97
Liver	alternative TSS	0	0	1.01
Liver	gene expression	0	0	1.03
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	0	0	1.02
Liver	mRNA stability	1	0	1.06
NAcc	alternative polyA	2	0.1	146.87
NAcc	alternative TSS	0	0	1.05
NAcc	gene expression	0	0	1.04
NAcc	isoform ratio	0	0	1.06
NAcc	intron excision ratio	1	0	1.03
NAcc	mRNA stability	0	0	1.02
OFC	alternative polyA	0	0	1.01
OFC	alternative TSS	0	0	1.12
OFC	gene expression	0	0	1.04
OFC	isoform ratio	0	0	1.11
OFC	intron excision ratio	0	0	1.08
OFC	mRNA stability	0	0	1
PL	alternative polyA	0	0	1.12
PL	alternative TSS	0	0	1.03
PL	gene expression	0	0	1.04
PL	isoform ratio	0	0	1.06
PL	intron excision ratio	0	0	1.05
PL	mRNA stability	0	0	1.02
pVTA	alternative polyA	0	0	1.04
pVTA	alternative TSS	0	0	1.03
pVTA	gene expression	1	0	1.08
pVTA	isoform ratio	0	0	1.08
pVTA	intron excision ratio	0	0	1.09
pVTA	mRNA stability	0	0	1.01
RMTg	alternative polyA	0	0	0.91
RMTg	alternative TSS	0	0	1.05
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1.06
RMTg	intron excision ratio	0	0	1.06
RMTg	mRNA stability	0	0	1.03