Hub : Traits

Distance traveled before self-admin

Distance traveled in cm at the first time point of open field before self admin

Tags: Behavior · Heroin · Open field test

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	14449451	15768722	1	1	3.76e-14	1.08e-01	1.00e+00	LOC102551633
2	chr19	32676171	34074113	1	1	2.44e-13	8.79e-02	2.07e-13	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Epididymis fat weight	3.94	1	0	0	0	1e+00	Zdhhc1
Left kidney weight	12.42	1	1	50	0	1e+00	Zdhhc1
Right kidney weight	12.86	1	1	50	0	1e+00	Zdhhc1
Parametrial fat weight	9.49	1	0	0	0	1e+00	Zdhhc1
Retroperitoneal fat weight	2.69	1	0	0	0	1e+00	Zdhhc1
Intraocular pressure	4.47	1	0	0	0	1e+00	Zdhhc1
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1e+00	LOC102551633
Patch foraging indifference point AUC	7.82	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 12 sec	3.95	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 18 sec	4.11	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 24 sec	6.8	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 6 sec	4.91	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Patch foraging water rate 18 sec	5.97	1	0	0	0	1e+00	Zdhhc1
Patch foraging water rate 6 sec	6.12	1	0	0	0	1e+00	Zdhhc1
Locomotor activity	6.36	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Locomotor testing distance	3.92	1	0	0	0	1e+00	LOC102551633
Locomotor testing rearing	6.23	1	0	0	0	1e+00	Zdhhc1
Light reinforcement 1	9.77	1	0	0	0	1e+00	Zdhhc1
Light reinforcement 2	4.91	1	0	0	0	1e+00	Zdhhc1
Reaction time number correct	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time mean minus median AUC	6.75	1	0	0	0	1e+00	Zdhhc1
Reaction time trials correct on left	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time trials on left	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time mean	24.17	1	1	50	0	1e+00	Zdhhc1
Reaction time mean AUC	19.64	1	0	0	0	1e+00	Zdhhc1
Median of all reaction times	26.45	1	1	50	0	1e+00	Zdhhc1
Std. dev. reaction times	8.62	1	0	0	0	1e+00	Zdhhc1
Reaction time trials completed	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time trials AUC	6.44	1	0	0	0	1e+00	Zdhhc1
Social response proportion	10.93	1	0	0	0	1e+00	Zdhhc1
Conditioned locomotion	5.5	1	0	0	0	1e+00	Zdhhc1
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	5.74	1	0	0	0	1e+00	LOC102551633
Conditioned locomotion	29.88	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Intermittent access intake escalation 2	13.41	1	0	0	0	1e+00	LOC102551633
Intermitt. access day 15 inactive lever presses	8.46	1	0	0	0	1e+00	Zdhhc1
Intermitt. access escalation Index	57.91	1	1	50	0	1e+00	LOC102551633
Intermittent access day 1 total infusions	14.77	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Intermittent access day 15 total infusions	10.19	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Intermittent access terminal intake (last 3 days)	33.03	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Intermittent access total infusions	12.94	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Intermittent access day 15 total locomotion	32.88	1	1	50	0	1e+00	LOC102551633
Intermittent access total locomotion	12.95	1	0	0	0	1e+00	LOC102551633
Post-drug Anxiety	8.64	1	0	0	0	1e+00	Zdhhc1
Lifetime Intake	14.29	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Incentive Sensitization - Responses	19.18	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Incentive Sensitization - Breakpoint	18.73	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Progressive ratio test 1 active lever presses	14.22	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Progressive ratio test 1 breakpoint	20.84	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Progressive ratio test 1 inactive lever presses	17.74	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Progressive ratio test 2 active lever presses	26.53	1	1	50	0	1e+00	Zdhhc1
Progressive ratio test 2 breakpoint	20.83	1	0	0	0	1e+00	Zdhhc1
Progressive ratio test 2 inactive lever presses	22.31	1	0	0	0	1e+00	LOC102551633
Total sessions with >9 infusions	48.24	1	1	50	0	1e+00	Zdhhc1
Short access day 1 total inactive lever presses	7.07	1	0	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	12.7	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Short access day 1 total infusions	45.37	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Short access day 10 total infusions	19.17	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Short access total infusions	25.95	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Short access day 1 locomotion	22.2	1	0	0	0	1e+00	LOC102551633
One hour access (shock baseline)	10.37	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Number of responses in last shaping day	15.19	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Locomotion distance, session 3	4.8	1	0	0	0	1e+00	LOC102551633
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone surface	3.9	1	0	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1e+00	Zdhhc1
Bone: final force	3.95	1	0	0	0	1e+00	LOC102551633
Bone: final moment	3.68	1	0	0	0	1e+00	LOC102551633
Bone: maximum force	3.84	1	0	0	0	1e+00	LOC102551633
Bone: maximum moment	3.51	1	0	0	0	1e+00	LOC102551633
Bone: stiffness	4.72	1	0	0	0	1e+00	LOC102551633
Bone: trabecular number	3.43	1	0	0	0	1e+00	Zdhhc1
Distance traveled after self-admin	46.63	1	1	50	0	1e+00	LOC102551633
Delta time in open arm before/after self-admin	13.01	1	0	0	0	1e+00	Zdhhc1
Extinction: sum of active levers before priming	16.17	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Active lever presses in extinction session 6	10.03	1	0	0	0	1e+00	Zdhhc1
Delta ambulatory time before/after self-admin	14.89	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Time in closed arm before self-admin	12.8	1	0	0	0	1e+00	Zdhhc1
Time in closed arm after self-admin	7.45	2	0	0	0	1e+00	LOC102551633 Zdhhc1
Time in open arm before self-admin	28.75	1	1	50	0	1e+00	LOC102551633
Time in open arm after self-admin	5.82	1	0	0	0	1e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	18.99	1	0	0	0	1e+00	LOC102551633
Time to tail flick, vehicle, before self-admin	36.23	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Time to tail flick, vehicle, after self-admin	51.7	1	1	50	0	1e+00	LOC102551633
Time to tail flick, test, after self-admin	5.3	1	0	0	0	1e+00	Zdhhc1
Delta time to tail flick, vehicle, before/after SA	122.63	1	1	50	0	1e+00	LOC102551633
Ambulatory time before self-admin	22.72	2	1	50	0	1e+00	LOC102551633 Zdhhc1
Ambulatory time after self-admin	16.68	1	0	0	0	1e+00	LOC102551633
Total heroin consumption	30.8	1	1	50	0	1e+00	LOC102551633
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1e+00	Zdhhc1
Time >=10cm from walls, locomotor time 1	16	1	0	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 1	5.83	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 1	5.4	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	4.87	1	0	0	0	1e+00	Zdhhc1
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 2	15.61	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 2	17.95	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 2	11.34	1	0	0	0	1e+00	Zdhhc1
Seeking ratio, delayed vs. immediate footshock	9.35	1	0	0	0	1e+00	LOC102551633
Progressive ratio	22.47	1	0	0	0	1e+00	Zdhhc1
Seeking ratio, punishment vs. effort	9.83	1	0	0	0	1e+00	Zdhhc1
Latency to leave start box in cocaine runway, F	9.76	1	0	0	0	1e+00	Zdhhc1
Latency to leave start box in cocaine runway, M	42.07	1	1	50	0	1e+00	Zdhhc1
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	50	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1
Adipose	alternative TSS	0	0	0.97
Adipose	gene expression	0	0	1.02
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	0.98
Adipose	mRNA stability	0	0	1.1
BLA	alternative polyA	0	0	1.16
BLA	alternative TSS	0	0	1.01
BLA	gene expression	0	0	1.06
BLA	isoform ratio	0	0	1.06
BLA	intron excision ratio	0	0	1.08
BLA	mRNA stability	0	0	1.05
Brain	alternative polyA	0	0	1.1
Brain	alternative TSS	0	0	1.07
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.04
Brain	intron excision ratio	0	0	1.04
Brain	mRNA stability	0	0	1.06
Eye	alternative polyA	0	0	1.03
Eye	alternative TSS	0	0	0.97
Eye	gene expression	0	0	1.02
Eye	isoform ratio	0	0	1.02
Eye	intron excision ratio	0	0	1.16
Eye	mRNA stability	0	0	1.06
IL	alternative polyA	0	0	1.08
IL	alternative TSS	0	0	0.98
IL	gene expression	0	0	1.11
IL	isoform ratio	0	0	1.03
IL	intron excision ratio	0	0	1.07
IL	mRNA stability	0	0	1.09
LHb	alternative polyA	0	0	1.2
LHb	alternative TSS	0	0	1.17
LHb	gene expression	0	0	1.05
LHb	isoform ratio	0	0	1.06
LHb	intron excision ratio	0	0	1.08
LHb	mRNA stability	0	0	1.09
Liver	alternative polyA	0	0	1.05
Liver	alternative TSS	0	0	0.99
Liver	gene expression	0	0	1.05
Liver	isoform ratio	0	0	1.02
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.06
NAcc	alternative polyA	0	0	1.11
NAcc	alternative TSS	0	0	1.11
NAcc	gene expression	0	0	1.09
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.06
NAcc	mRNA stability	1	0	1.09
OFC	alternative polyA	0	0	1.12
OFC	alternative TSS	0	0	1.09
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1.05
OFC	mRNA stability	0	0	1.1
PL	alternative polyA	0	0	1.13
PL	alternative TSS	0	0	1.07
PL	gene expression	0	0	1.07
PL	isoform ratio	0	0	1.08
PL	intron excision ratio	0	0	1.07
PL	mRNA stability	0	0	1.06
pVTA	alternative polyA	0	0	1.13
pVTA	alternative TSS	0	0	0.97
pVTA	gene expression	0	0	1.08
pVTA	isoform ratio	0	0	1.07
pVTA	intron excision ratio	0	0	1.08
pVTA	mRNA stability	0	0	1.12
RMTg	alternative polyA	1	0.2	1.21
RMTg	alternative TSS	0	0	0.94
RMTg	gene expression	0	0	1.08
RMTg	isoform ratio	0	0	1.09
RMTg	intron excision ratio	0	0	1.06
RMTg	mRNA stability	0	0	1.07