Hub : Genes

P4ha3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression P4ha3 0.18 0.09 3.0e-14 0.13 0.12 0.12 0.12 5.6e-14 2.4e-13 5.4e-13 2.0e-13
2 IC gene expression P4ha3 0.21 0.11 3.2e-06 0.14 0.14 0.14 0.14 1.7e-06 1.8e-06 2.3e-06 1.9e-06
3 BLA gene expression P4ha3 0.08 0.06 1.2e-03 0.04 0.04 0.03 0.03 4.6e-03 4.4e-03 8.5e-03 1.2e-02
4 pVTA gene expression P4ha3 0.34 0.15 0.0e+00 0.18 0.23 0.23 0.24 1.5e-14 1.5e-18 3.3e-18 4.9e-19
5 IL mRNA stability P4ha3 0.24 0.15 4.0e-04 0.06 0.04 0.01 0.02 1.4e-02 3.4e-02 1.5e-01 1.3e-01
6 OFC mRNA stability P4ha3 0.38 0.18 2.0e-07 0.25 0.23 0.23 0.22 1.5e-06 3.4e-06 3.8e-06 5.3e-06
7 Brain mRNA stability P4ha3 0.25 0.13 0.0e+00 0.26 0.25 0.25 0.26 7.6e-24 3.6e-23 2.5e-23 6.9e-24
8 BLA mRNA stability P4ha3 0.27 0.14 4.1e-12 0.2 0.21 0.21 0.2 1.4e-10 3.5e-11 2.7e-11 4.4e-11
9 PL mRNA stability P4ha3 0.45 0.18 0.0e+00 0.29 0.31 0.31 0.29 5.5e-32 6.8e-34 6.8e-34 6.2e-32
10 IC mRNA stability P4ha3 0.26 0.12 2.2e-10 0.13 0.18 0.17 0.16 3.5e-06 6.8e-08 1.6e-07 1.9e-07
11 BLA intron excision ratio chr1_164041088_164046678 0.07 0.06 2.4e-03 0.03 0.03 0.02 0.02 9.3e-03 1.0e-02 2.0e-02 1.8e-02
12 NAcc gene expression P4ha3 0.23 0.13 0.0e+00 0.15 0.15 0.14 0.15 6.6e-22 5.6e-22 3.4e-21 9.7e-22
13 Brain gene expression P4ha3 0.23 0.13 2.7e-12 0.13 0.12 0.11 0.13 3.5e-12 1.2e-11 1.1e-10 8.5e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.31.10.70.7-0.1-1.0-0.3-0.30.3-0.10.00.1-0.1-0.91.0
Area under the delay curve0.10.20.3-0.3-0.3-0.40.10.40.4-0.40.4-0.5-0.4-0.50.5-0.6
BMI with tail0.62.34.7-0.8-0.9-1.11.81.51.5-1.51.3-1.3-1.3-1.42.2-2.2
BMI without tail0.52.88.2-1.6-1.7-0.52.61.31.3-1.31.0-0.9-1.0-1.12.9-2.7
Body weight1.04.310.3-1.4-1.5-1.22.81.91.9-1.91.6-1.6-1.7-1.73.2-3.2
Weight adjusted by age0.10.31.3-0.8-0.7-0.20.80.20.2-0.20.2-0.4-0.3-0.41.0-1.1
Bone surface0.30.61.4-1.2-1.10.80.9-0.8-0.80.8-0.80.70.70.40.6-0.4
Bone volume0.10.30.5-0.7-0.70.60.5-0.6-0.60.6-0.60.40.50.30.3-0.2
Breakpoint value in progressive ratio session0.40.72.21.31.3-0.5-1.50.20.2-0.20.2-0.3-0.2-0.1-1.31.1
Number of licking bursts1.85.37.92.32.3-2.8-1.22.62.6-2.62.7-2.7-2.7-2.7-0.0-0.1
Context. condit. distance diff. score2.42.94.5-1.5-1.52.10.6-2.0-2.02.0-2.02.12.02.1-0.20.2
Locomotion velocity, session 10.40.51.70.70.70.2-1.1-0.4-0.40.4-0.40.30.40.4-1.21.3
Locomotion distance, session 11.01.32.0-0.8-0.81.40.1-1.4-1.41.4-1.41.31.41.4-0.40.5
Locomotion velocity, session 20.00.10.1-0.4-0.40.10.4-0.1-0.10.1-0.10.10.10.00.3-0.3
Locomotion distance, session 20.50.71.1-0.8-0.81.00.3-1.0-1.01.0-0.90.90.91.0-0.10.2
Locomotion velocity, session 31.11.31.9-0.6-0.61.3-0.2-1.4-1.41.4-1.31.31.31.3-0.70.8
Locomotion distance, session 31.82.13.2-0.7-0.71.7-0.3-1.8-1.81.8-1.81.71.71.7-0.91.0
Stereotopy head waving bouts, day 30.70.81.20.50.5-1.00.21.11.1-1.11.1-1.0-1.1-1.10.6-0.6
Stereotopy head waving duration, day 30.10.20.3-0.2-0.20.50.0-0.4-0.40.4-0.50.50.50.5-0.20.2
Locomotion velocity, session 70.20.20.60.60.6-0.1-0.70.10.1-0.10.1-0.0-0.00.0-0.70.8
Locomotion distance, session 70.10.10.20.50.5-0.4-0.30.40.4-0.40.4-0.4-0.4-0.4-0.10.2
Stereotopy head waving bouts, day 72.63.04.5-1.7-1.72.10.7-2.0-2.02.0-2.02.02.02.1-0.10.1
Stereotopy head waving duration, day 72.53.14.5-2.0-2.02.11.2-1.9-1.91.9-2.02.02.02.00.4-0.3
Locomotion velocity, session 80.70.81.2-0.9-0.91.10.5-1.1-1.11.1-1.01.01.01.10.00.1
Locomotion distance, session 82.23.14.8-1.8-1.82.10.9-2.0-2.02.0-1.92.12.02.20.1-0.0
Degree of sensitization distance2.32.53.50.30.3-1.60.91.91.9-1.91.8-1.8-1.8-1.81.5-1.6
Degree of sensitization stereotypy5.15.78.3-2.5-2.52.91.2-2.7-2.72.7-2.72.72.72.80.1-0.0
Conditioned locomotion0.20.30.70.50.50.2-0.7-0.4-0.40.4-0.30.30.30.4-0.80.9
Cocaine response after cond. corrected1.62.33.41.31.3-1.9-0.41.81.8-1.81.8-1.8-1.8-1.80.3-0.6
Cocaine response after cond. not corrected0.40.50.80.70.8-0.9-0.30.90.9-0.90.8-0.8-0.8-0.80.1-0.3
Cocaine response before conditioning2.42.94.4-1.2-1.22.10.2-2.0-2.02.0-2.12.12.12.0-0.60.7
Saline control response0.91.33.0-1.7-1.71.11.6-0.8-0.80.8-0.80.90.80.81.1-1.2
Bone: connectivity density0.30.51.30.40.30.4-0.8-0.7-0.70.7-0.60.50.50.4-0.91.1
Bone: cortical apparent density1.42.23.51.51.5-1.9-0.81.61.6-1.61.7-1.8-1.8-1.7-0.10.1
Bone: cortical area0.10.20.8-0.7-0.6-0.00.90.10.1-0.10.1-0.2-0.2-0.30.9-0.8
Bone: cortical porosity1.21.31.9-0.4-0.41.2-0.3-1.4-1.41.4-1.31.41.31.4-0.80.9
Bone: cortical porosity1.21.42.1-0.5-0.51.3-0.2-1.4-1.41.4-1.31.41.41.5-0.70.9
Bone: cortical thickness0.20.30.80.80.9-0.6-0.80.30.3-0.30.5-0.5-0.5-0.4-0.50.7
Bone: cortical thickness0.20.20.5-0.4-0.30.50.1-0.7-0.70.7-0.50.40.50.4-0.10.3
Bone: cortical tissue density1.32.13.21.61.5-1.8-1.01.51.5-1.51.6-1.7-1.7-1.7-0.20.2
Condit. Reinf. active minus inactive responses0.30.30.9-0.6-0.6-0.10.90.30.3-0.30.2-0.3-0.3-0.30.9-0.9
Condit. Reinf. active-inactive response ratio0.50.51.6-1.0-1.00.11.20.10.1-0.10.1-0.1-0.1-0.11.2-1.2
Condit. Reinf. active responses0.10.10.3-0.2-0.2-0.20.40.40.4-0.40.3-0.3-0.3-0.30.5-0.5
Condit. Reinf. inactive responses0.00.00.10.30.3-0.0-0.30.00.0-0.0-0.00.00.00.0-0.30.3
Incentive salience index mean0.20.30.8-0.7-0.70.00.90.10.1-0.10.1-0.1-0.1-0.20.9-0.8
Condit. Reinf. lever presses0.10.20.4-0.7-0.70.30.6-0.3-0.30.3-0.30.20.20.20.5-0.3
Condit. Reinf. active minus inactive responses3.75.613.6-3.7-3.72.23.3-1.7-1.71.7-1.81.71.71.62.4-2.1
Condit. Reinf. active-inactive response ratio0.71.12.6-1.6-1.61.11.3-0.9-0.90.9-0.90.90.90.80.9-0.7
Condit. Reinf. active responses5.58.019.6-4.4-4.42.54.1-1.9-1.91.9-1.91.81.91.63.1-2.8
Condit. Reinf. inactive responses2.74.09.9-3.1-3.11.63.0-1.2-1.21.2-1.21.21.21.02.4-2.3
Condit. Reinf. lever presses10.615.431.9-5.6-5.64.24.7-3.4-3.43.4-3.53.53.53.23.0-2.5
Condit. Reinf. lever reinforcers received6.59.121.9-4.7-4.72.84.2-2.1-2.12.1-2.22.12.11.93.1-2.8
Conditioned reinforcement - actives0.62.43.3-1.3-1.41.80.5-1.8-1.81.8-1.81.81.81.8-0.20.5
Conditioned reinforcement - inactives0.10.20.50.70.7-0.2-0.60.30.3-0.30.10.0-0.1-0.1-0.50.5
Conditioned locomotion3.24.77.3-1.2-1.22.5-0.0-2.6-2.62.6-2.72.62.62.7-1.11.5
Patch foraging indifference point 0 sec1.54.37.7-2.6-2.82.41.8-2.1-2.12.1-2.12.12.12.11.0-1.1
Patch foraging indifference point AUC0.30.61.7-0.5-0.6-0.51.00.50.5-0.50.7-0.7-0.7-0.81.3-1.3
Delay disc. indifference point, 0s delay0.70.82.1-1.5-1.50.81.2-0.6-0.60.6-0.70.60.70.70.9-0.9
Delay disc. indifference point, 16s delay0.00.00.20.10.2-0.2-0.40.00.0-0.00.1-0.1-0.1-0.2-0.20.2
Delay disc. indifference point, 2s delay0.60.72.0-1.3-1.40.21.30.20.2-0.20.0-0.1-0.0-0.31.4-1.4
Delay disc. indifference point, 24s delay0.40.71.11.01.0-1.0-1.00.70.7-0.70.8-0.9-0.8-1.1-0.50.5
Delay disc. indifference point, 4s delay1.01.13.3-1.6-1.60.11.70.10.1-0.10.2-0.2-0.2-0.41.8-1.7
Delay disc. indifference point, 8s delay0.00.10.2-0.3-0.4-0.2-0.00.10.1-0.10.2-0.2-0.2-0.10.4-0.5
Indifference point function ln k1.03.04.5-0.9-0.92.0-0.4-2.1-2.12.1-2.12.02.12.1-1.21.3
Indifference point function log k1.03.04.5-0.9-0.92.0-0.4-2.1-2.12.1-2.12.02.12.1-1.21.3
Patch foraging total patch changes 0 sec1.23.56.8-2.5-2.62.11.8-1.8-1.81.8-1.81.81.81.81.0-1.1
Patch foraging total patch changes 12 sec0.91.23.3-1.6-1.70.21.8-0.1-0.10.10.1-0.1-0.1-0.11.8-1.8
Patch foraging total patch changes 18 sec0.92.04.9-2.1-2.21.32.0-0.9-0.90.9-1.01.01.00.91.5-1.6
Patch foraging total patch changes 24 sec0.30.92.9-1.5-1.50.31.70.00.0-0.0-0.00.10.0-0.11.6-1.4
Patch foraging total patch changes 6 sec0.50.81.6-1.2-1.30.90.8-1.0-1.01.0-0.70.70.80.70.5-0.4
Patch foraging time to switch 0 sec0.93.57.52.72.7-1.9-2.01.61.6-1.61.6-1.6-1.6-1.5-1.51.5
Patch foraging water rate 0 sec0.93.66.3-2.5-2.52.21.6-1.9-1.91.9-1.91.91.91.80.9-0.8
Patch foraging water rate 12 sec0.72.94.3-1.7-1.62.10.7-2.0-2.02.0-2.02.12.01.8-0.10.3
Patch foraging water rate 18 sec0.41.02.3-1.5-1.41.11.2-0.9-0.90.9-0.90.90.90.80.8-0.4
Patch foraging water rate 24 sec1.82.64.5-0.9-0.81.8-0.2-2.1-2.12.1-1.91.81.91.8-0.91.2
Patch foraging water rate 6 sec1.01.52.5-0.8-0.91.50.2-1.5-1.51.5-1.51.61.51.4-0.30.6
Seeking ratio, delayed vs. immediate footshock0.81.23.61.81.9-0.6-1.50.70.7-0.70.4-0.2-0.4-0.2-1.51.2
Distance traveled before self-admin0.40.81.41.00.9-1.1-0.70.80.8-0.81.1-1.2-1.1-1.0-0.10.1
Distance traveled after self-admin0.81.44.41.41.40.3-1.8-0.5-0.50.5-0.60.50.50.6-2.02.1
Extensor digitorum longus weight0.52.02.8-0.0-0.1-1.41.11.51.5-1.51.6-1.6-1.6-1.51.6-1.7
Bone: elastic displacement1.21.53.92.01.9-1.0-2.00.60.6-0.60.7-0.7-0.7-0.7-1.51.4
Bone: elastic work1.31.64.42.02.0-0.9-2.10.40.4-0.40.6-0.6-0.6-0.5-1.71.7
Bone: endosteal estimation0.92.27.0-2.2-2.10.52.6-0.0-0.00.0-0.10.10.1-0.22.4-2.4
Bone: endosteal perimeter1.02.47.4-2.5-2.40.82.7-0.3-0.30.3-0.40.30.40.12.3-2.4
Epididymis fat weight0.21.22.20.90.8-1.3-0.21.51.5-1.51.2-1.2-1.2-1.20.3-0.6
Delta time in closed arm before/after self-admin3.43.25.20.80.8-2.00.42.32.3-2.32.2-2.1-2.1-2.11.2-1.2
Delta time in open arm before/after self-admin1.41.63.0-1.7-1.71.41.5-1.0-1.01.0-1.31.31.21.20.9-1.1
Diff in mean of infusions in LGA sessions2.44.38.22.62.9-2.3-2.02.12.1-2.12.0-1.9-2.0-1.9-1.21.2
Delay discount exponential model param0.10.20.40.30.30.4-0.1-0.4-0.40.4-0.40.50.40.6-0.50.6
Extinction: sum of active levers before priming0.10.10.3-0.1-0.1-0.10.40.40.4-0.40.1-0.1-0.1-0.10.4-0.6
Active lever presses in extinction session 64.44.56.9-0.5-0.62.3-1.1-2.6-2.62.6-2.52.42.52.6-1.81.6
Bone: final force0.00.10.20.40.4-0.3-0.30.20.2-0.20.3-0.3-0.3-0.3-0.10.1
Bone: final moment0.00.00.00.20.1-0.2-0.10.00.0-0.00.2-0.1-0.2-0.2-0.0-0.0
Food consumed during 24 hour testing period2.04.06.0-2.0-2.02.41.0-2.3-2.32.3-2.32.32.32.20.10.1
Glucose0.00.00.10.00.0-0.20.00.10.1-0.10.2-0.3-0.2-0.30.10.0
Heart weight0.71.11.7-1.2-1.21.20.8-1.1-1.11.1-1.11.21.11.30.3-0.1
Delay discount hyperbolic model param0.20.30.70.50.50.4-0.4-0.5-0.50.5-0.50.60.50.7-0.80.9
Intermittent access intake day 1-15 change0.21.02.3-0.7-0.71.00.1-1.5-1.51.5-1.00.91.00.9-0.30.4
Intermittent access intake escalation0.21.32.7-0.8-0.81.20.2-1.6-1.61.6-1.21.11.21.1-0.30.5
Intermittent access intake escalation 20.40.71.6-1.0-1.00.90.5-1.3-1.31.3-0.70.60.70.70.30.1
Intermitt. access day 1 inactive lever presses0.11.52.01.31.3-1.4-0.61.41.4-1.41.4-1.2-1.3-1.3-0.10.3
Intermitt. access day 15 inactive lever presses0.10.61.81.41.3-0.3-1.20.10.1-0.10.1-0.0-0.10.0-1.31.3
Intermitt. access escalation Index0.00.00.1-0.4-0.30.10.2-0.1-0.10.1-0.1-0.00.10.00.20.1
Intermittent access day 1 total infusions0.61.73.4-1.2-1.11.70.8-1.2-1.21.2-1.61.81.61.7-0.10.2
Intermittent access day 15 total infusions1.02.43.6-1.3-1.31.90.5-1.9-1.91.9-1.91.91.81.8-0.30.6
Intermittent access terminal intake (last 3 days)1.52.73.8-1.7-1.71.90.8-2.0-2.02.0-1.91.81.81.80.10.2
Intermittent access total infusions1.51.82.9-1.5-1.41.71.1-1.3-1.31.3-1.61.71.51.50.3-0.1
Intermittent access day 1 locomotion0.40.71.2-0.2-0.20.9-0.0-0.9-0.90.9-1.11.11.01.1-0.60.8
Intermittent access day 15 total locomotion0.62.33.9-0.7-0.71.7-0.1-2.0-2.02.0-1.81.81.71.8-0.91.0
Intermittent access total locomotion1.01.22.3-0.7-0.71.40.3-1.3-1.31.3-1.41.51.41.4-0.40.5
Intermittent access standard deviation0.10.41.1-0.8-0.9-0.21.00.00.0-0.00.4-0.5-0.3-0.41.0-1.0
Left kidney weight0.21.95.5-1.3-1.3-0.62.00.90.9-0.91.0-1.0-1.0-1.02.3-2.3
Right kidney weight0.42.77.9-1.6-1.6-0.72.51.11.1-1.11.1-1.1-1.1-1.22.8-2.7
Cocaine induced anxiety0.51.32.61.61.6-1.3-1.40.90.9-0.91.1-1.2-1.1-1.1-0.70.6
Post-drug Anxiety1.61.82.81.71.6-1.6-1.21.31.3-1.31.4-1.4-1.4-1.4-0.50.5
Baseline Anxiety0.10.10.3-0.5-0.60.20.60.20.2-0.2-0.20.30.10.10.5-0.5
Tail length0.84.011.8-2.0-2.0-0.73.11.41.4-1.41.2-1.2-1.2-1.23.4-3.3
Length with tail0.62.77.8-1.5-1.4-0.62.61.31.3-1.30.9-0.9-1.0-1.02.7-2.8
Length without tail0.10.30.50.40.5-0.60.00.70.7-0.70.6-0.5-0.6-0.60.1-0.3
Times rat made contact with spout0.80.91.60.20.2-1.10.31.11.1-1.11.1-1.2-1.2-1.30.9-0.8
Lifetime Intake1.82.23.9-1.5-1.51.91.2-1.4-1.41.4-1.82.01.81.70.2-0.1
Liver weight, left0.81.32.3-0.3-0.2-1.01.11.21.2-1.21.2-1.2-1.2-1.31.5-1.4
Liver weight, right2.13.75.40.40.5-2.10.92.32.3-2.32.3-2.2-2.3-2.31.7-1.8
Locomotor activity0.60.91.5-1.2-1.21.00.4-1.2-1.21.2-0.80.70.90.90.3-0.1
Locomotor testing distance0.71.84.7-2.2-2.21.11.7-1.1-1.11.1-0.90.80.90.81.4-1.1
Locomotor testing rearing0.30.92.8-1.3-1.40.01.6-0.0-0.00.00.3-0.3-0.3-0.31.7-1.6
Locomotion in novel chamber1.11.53.0-0.6-0.71.2-0.4-1.7-1.71.7-1.21.01.31.4-0.71.0
Locomotion in novel chamber post-restriction0.92.64.0-1.4-1.51.90.7-1.9-1.91.9-1.91.91.92.0-0.10.4
Fecal boli incidents, locomotor time 10.51.32.2-0.5-0.51.3-0.2-1.3-1.31.3-1.51.41.41.5-0.80.9
Change in fecal boli incidents, locomotor task0.70.71.00.91.0-1.0-0.40.90.9-0.91.0-0.9-0.9-1.0-0.10.3
Time >=10cm from walls, locomotor time 11.82.33.3-1.3-1.31.80.5-1.8-1.81.8-1.81.81.81.8-0.20.3
Bouts of movement, locomotor time 10.10.20.4-0.3-0.30.60.3-0.4-0.40.4-0.60.50.50.5-0.00.0
Total resting periods, locomotor time 10.40.40.80.10.20.7-0.2-0.6-0.60.6-0.90.80.80.8-0.80.7
Rest time, locomotor task time 10.30.61.50.70.80.5-0.8-0.5-0.50.5-0.60.70.60.8-1.21.1
Distance moved, locomotor task time 10.30.82.0-0.8-0.7-0.61.00.50.5-0.50.8-0.9-0.8-1.01.4-1.4
Vertical activity count, locomotor time 10.10.51.6-1.0-1.0-0.11.00.20.2-0.20.4-0.2-0.3-0.31.3-1.1
Time >=10cm from walls, locomotor time 20.41.22.4-1.5-1.51.11.3-1.0-1.01.0-0.91.01.01.00.8-0.7
Bouts of movement, locomotor time 20.20.62.3-0.9-0.9-0.21.50.30.3-0.30.3-0.5-0.4-0.61.4-1.1
Total resting periods, locomotor time 20.10.51.3-0.5-0.5-0.41.10.50.5-0.50.6-0.7-0.6-0.71.1-0.9
Rest time, locomotor task time 21.32.24.92.22.2-1.6-1.71.31.3-1.31.5-1.2-1.3-1.2-1.10.9
Distance moved, locomotor task time 21.72.25.4-2.3-2.31.41.9-1.2-1.21.2-1.11.11.10.91.4-1.4
Vertical activity count, locomotor time 20.41.02.8-1.7-1.60.61.5-0.4-0.40.4-0.30.40.40.31.4-1.2
Light reinforcement 10.73.04.62.12.1-2.0-1.41.91.9-1.91.8-1.8-1.8-1.8-0.6-0.0
Light reinforcement 20.10.31.10.90.8-0.2-1.1-0.1-0.10.1-0.00.00.00.1-0.90.6
Bone: marrow area0.82.06.3-2.1-2.00.32.50.10.1-0.10.0-0.1-0.1-0.32.3-2.4
Bone: maximum diameter0.91.74.8-2.1-2.00.82.2-0.5-0.50.5-0.50.50.50.41.8-1.8
Bone: maximum force0.00.00.10.20.2-0.2-0.20.00.0-0.00.1-0.1-0.1-0.1-0.1-0.0
Bone: maximum moment0.00.00.0-0.0-0.1-0.00.0-0.1-0.10.10.0-0.0-0.0-0.00.1-0.1
Mean time between licks in bursts0.63.710.8-2.9-2.90.83.3-0.3-0.30.3-0.30.40.30.23.0-3.1
Mean num. licks in bursts1.54.16.0-2.1-2.22.41.2-2.3-2.32.3-2.32.32.32.20.3-0.2
Cd content in liver0.70.81.20.40.3-1.00.31.11.1-1.11.1-1.0-1.1-1.00.7-0.8
Co content in liver0.80.92.6-1.5-1.50.61.6-0.2-0.20.2-0.30.30.30.31.4-1.4
Cu content in liver1.11.34.1-1.0-1.1-0.41.70.80.8-0.80.8-0.7-0.7-0.61.9-2.0
Fe content in liver0.00.00.10.30.2-0.2-0.20.20.2-0.20.2-0.1-0.10.0-0.1-0.0
K content in liver0.40.40.60.10.1-0.70.40.70.7-0.70.8-0.7-0.7-0.70.6-0.6
Mg content in liver0.10.10.2-0.4-0.40.20.4-0.1-0.10.1-0.10.10.10.20.3-0.3
Mn content in liver0.80.92.81.41.4-0.3-1.7-0.0-0.00.00.0-0.0-0.00.0-1.61.6
Na content in liver0.40.40.6-0.8-0.70.80.5-0.6-0.60.6-0.70.70.70.70.2-0.2
Rb content in liver0.20.20.5-0.7-0.70.50.5-0.4-0.40.4-0.40.50.50.50.3-0.3
Se content in liver2.93.48.02.82.8-1.8-2.51.41.4-1.41.5-1.4-1.4-1.2-1.81.7
Sr content in liver0.30.30.4-0.1-0.10.6-0.3-0.6-0.60.6-0.60.60.60.6-0.50.6
Zn content in liver1.71.94.7-2.2-2.21.22.1-0.8-0.80.8-0.80.90.90.81.6-1.6
Bone: minimum diameter1.12.15.6-1.3-1.2-0.62.21.01.0-1.00.9-1.0-1.0-1.12.4-2.4
Time in familiar zone, hab. session 10.10.20.3-0.1-0.1-0.30.40.40.4-0.40.4-0.4-0.4-0.40.6-0.5
Time in novel zone, hab. session 10.20.20.30.50.5-0.5-0.30.40.4-0.40.4-0.5-0.5-0.4-0.20.0
Total zone transitions, hab. session 10.40.51.20.30.30.6-0.7-0.8-0.80.8-0.70.70.70.8-1.01.1
Total locomotion distance, hab. session 11.52.23.20.40.4-1.70.61.81.8-1.81.8-1.8-1.8-1.71.3-1.3
Locomotion velocity, hab. session 10.91.31.80.30.3-1.20.51.31.3-1.31.4-1.4-1.4-1.21.0-1.1
Time in familiar zone, hab. session 20.91.12.3-1.5-1.51.01.4-0.8-0.80.8-0.80.90.80.91.0-0.8
Time in novel zone, hab. session 20.30.30.80.80.8-0.3-0.90.20.2-0.20.2-0.2-0.2-0.3-0.80.6
Total zone transitions, hab. session 21.62.13.2-1.0-1.01.70.2-1.7-1.71.7-1.71.71.71.8-0.50.6
Total locomotion distance, hab. session 20.91.12.5-0.5-0.5-0.81.21.01.0-1.01.0-1.0-1.0-0.91.5-1.6
Locomotion velocity, hab. session 21.21.53.1-0.4-0.4-1.01.31.31.3-1.31.3-1.2-1.2-1.21.7-1.8
Novel to familiar place preference ratio0.00.00.1-0.2-0.20.30.1-0.2-0.20.2-0.30.30.30.3-0.0-0.1
Novelty place preference0.00.00.1-0.2-0.20.30.1-0.2-0.20.2-0.30.30.30.3-0.0-0.1
Time in novel zone, NPP test0.10.20.3-0.4-0.40.50.2-0.4-0.40.4-0.50.50.50.5-0.0-0.1
Total zone transitions, NPP test0.40.60.9-0.2-0.20.8-0.3-0.9-0.90.9-0.90.80.91.0-0.60.7
Total locomotion distance, NPP test1.01.42.10.20.2-1.30.71.41.4-1.41.4-1.4-1.4-1.41.1-1.2
Locomotion velocity, NPP test1.31.92.80.50.5-1.60.41.61.6-1.61.7-1.7-1.7-1.61.0-1.1
Intraocular pressure0.40.61.20.0-0.00.8-0.5-1.1-1.11.1-0.90.80.80.7-0.80.9
Delta distance traveled before/after self-admin2.32.54.2-0.7-0.61.9-0.0-1.8-1.81.8-2.02.12.02.0-1.01.3
Delta ambulatory time before/after self-admin1.52.64.5-0.6-0.62.0-0.1-1.8-1.81.8-2.12.12.02.0-1.11.4
Parametrial fat weight0.71.62.61.21.2-1.4-0.41.61.6-1.61.3-1.3-1.4-1.40.1-0.5
Pavlov. Cond. lever latency1.01.32.71.61.6-1.2-1.31.01.0-1.01.0-1.0-1.0-1.0-0.90.7
Pavlov. Cond. magazine entry latency2.22.85.8-2.4-2.41.82.0-1.4-1.41.4-1.51.51.51.41.3-1.2
Pavlov. Cond. change in total contacts1.01.12.2-1.5-1.51.11.2-0.9-0.90.9-0.90.90.90.90.8-0.7
Pavlov. Cond. index score1.92.45.2-2.3-2.31.61.9-1.3-1.31.3-1.31.31.31.31.3-1.1
Pavlov. Cond. latency score1.82.34.9-2.2-2.21.61.8-1.3-1.31.3-1.41.31.31.31.2-1.0
Pavlov. Cond. lever contacts0.91.12.5-1.6-1.61.01.4-0.8-0.80.8-0.80.80.80.81.0-0.8
Pavlov. Cond. magazine entry number2.32.95.92.42.4-1.8-2.01.51.5-1.51.5-1.5-1.5-1.5-1.31.1
Pavlov. Cond. intertrial magazine entries0.60.81.71.31.3-0.8-1.20.70.7-0.70.7-0.7-0.7-0.6-0.80.8
Pavlov. Cond. lever-magazine prob. diff.1.51.94.1-2.0-2.01.41.7-1.1-1.11.1-1.21.21.21.21.1-0.9
Pavlov. Cond. response bias1.01.32.8-1.7-1.71.21.4-0.9-0.90.9-1.01.01.00.90.9-0.8
Pavlov. Cond. lever latency12.217.133.05.75.7-4.5-4.44.04.0-4.03.9-3.9-3.9-3.7-2.62.1
Pavlov. Cond. magazine entry latency2.94.26.0-2.4-2.32.41.4-2.2-2.22.2-2.22.32.32.10.5-0.2
Pavlov. Cond. change in total contacts5.413.124.3-4.9-4.94.03.7-3.5-3.53.5-3.53.53.53.42.1-1.6
Pavlov. Cond. index score8.112.723.7-4.9-4.84.03.6-3.5-3.53.5-3.43.53.53.32.1-1.6
Pavlov. Cond. latency score7.011.220.3-4.5-4.43.83.3-3.3-3.33.3-3.33.33.33.11.8-1.4
Pavlov. Cond. lever contacts10.916.131.4-5.6-5.54.44.4-3.8-3.83.8-3.73.73.73.52.6-2.1
Pavlov. Cond. magazine entry number5.57.210.23.23.1-3.2-2.02.92.9-2.92.9-2.9-2.9-2.8-0.70.5
Pavlov. Cond. intertrial magazine entries0.51.22.9-0.6-0.6-0.81.31.01.0-1.00.9-1.0-1.0-0.91.6-1.7
Pavlov. Cond. lever-magazine prob. diff.7.611.622.4-4.7-4.73.83.6-3.2-3.23.2-3.23.23.23.12.1-1.7
Pavlov. Cond. response bias12.216.931.2-5.6-5.54.64.2-4.0-4.04.0-4.04.04.03.82.4-1.9
Time in closed arm before self-admin2.03.55.6-0.9-0.92.2-0.3-2.4-2.42.4-2.22.22.22.2-1.11.3
Time in closed arm after self-admin0.50.62.31.11.2-0.4-1.2-0.1-0.10.10.2-0.2-0.2-0.1-1.21.5
Time in open arm before self-admin2.63.24.91.81.6-2.2-1.21.91.9-1.92.1-2.2-2.1-2.1-0.0-0.1
Time in open arm after self-admin0.60.62.5-0.5-0.6-0.40.90.70.7-0.70.5-0.5-0.6-0.61.2-1.6
Bone: periosteal estimation0.71.55.0-1.9-1.80.42.2-0.0-0.00.0-0.1-0.0-0.0-0.22.0-2.0
Bone: periosteal perimeter0.71.44.3-1.8-1.70.52.1-0.1-0.10.1-0.20.10.1-0.11.8-1.9
Bone: post-yield work0.00.00.2-0.3-0.30.10.30.00.0-0.0-0.00.00.00.00.3-0.4
Progressive ratio test 1 active lever presses0.20.41.00.40.50.4-0.5-0.4-0.40.4-0.60.70.60.6-0.91.0
Progressive ratio test 1 breakpoint0.20.30.90.40.50.4-0.4-0.3-0.30.3-0.60.70.50.6-0.81.0
Progressive ratio test 1 inactive lever presses0.10.30.60.60.70.3-0.50.10.1-0.1-0.40.70.50.5-0.80.7
Progressive ratio test 2 active lever presses0.30.40.9-0.9-0.90.60.6-0.6-0.60.6-0.60.60.60.60.5-0.2
Progressive ratio test 2 breakpoint0.30.40.9-0.9-0.90.70.6-0.6-0.60.6-0.60.70.60.60.5-0.2
Progressive ratio test 2 inactive lever presses0.20.61.3-0.3-0.40.9-0.0-0.8-0.80.8-1.01.11.01.1-0.40.4
Incentive Sensitization - Responses0.30.82.2-1.5-1.50.70.9-0.8-0.80.8-0.50.50.50.51.0-0.8
Incentive Sensitization - Breakpoint0.30.71.9-1.4-1.40.70.8-0.8-0.80.8-0.50.50.60.50.8-0.7
Sum of active levers in priming session hrs 5-60.10.10.30.20.20.2-0.6-0.5-0.50.5-0.30.20.30.3-0.50.1
Progressive ratio0.20.71.3-0.4-0.40.9-0.1-1.1-1.11.1-1.01.00.91.1-0.40.3
Food seeking constrained by brief footshock0.91.12.8-1.7-1.60.51.7-0.4-0.40.4-0.30.10.20.11.6-1.6
Seeking ratio, punishment vs. effort0.61.33.4-1.2-1.0-0.41.80.90.9-0.90.7-0.7-0.7-0.91.8-1.8
Retroperitoneal fat weight3.113.921.91.71.6-4.20.84.74.7-4.74.4-4.4-4.4-4.42.4-2.9
Reaction time number correct0.41.42.20.20.31.0-1.1-1.4-1.41.4-1.21.01.21.1-1.51.5
Reaction time mean minus median0.10.61.6-1.2-1.30.61.1-0.3-0.30.3-0.50.50.40.31.0-1.1
Reaction time mean minus median AUC0.21.01.5-1.2-1.21.20.8-1.0-1.01.0-1.21.11.11.10.4-0.5
Reaction time num false alarms1.52.64.01.31.3-2.0-0.61.91.9-1.92.0-2.0-1.9-1.80.3-0.4
Reaction time num false alarms AUC0.51.21.80.90.9-1.4-0.51.31.3-1.31.3-1.4-1.3-1.10.1-0.2
Reaction time trials correct on left0.41.42.20.20.31.0-1.1-1.4-1.41.4-1.21.01.21.1-1.51.5
Reaction time trials on left0.41.42.30.20.31.0-1.2-1.4-1.41.4-1.21.01.21.1-1.51.5
Reaction time mean0.61.42.60.90.8-1.3-0.31.61.6-1.61.3-1.2-1.3-1.30.4-0.7
Reaction time mean AUC0.61.52.71.31.2-1.3-0.71.61.6-1.61.2-1.2-1.3-1.3-0.0-0.2
Median of all reaction times1.32.03.51.41.3-1.6-0.91.91.9-1.91.5-1.4-1.5-1.5-0.0-0.3
Reaction time omissions0.30.50.80.00.0-0.70.40.90.9-0.90.8-0.7-0.7-0.70.7-0.9
Reaction time false alarm rate1.72.33.80.80.8-1.8-0.12.02.0-2.01.9-1.8-1.8-1.70.7-0.7
Reaction time premature initiation rate1.42.16.8-1.7-1.8-0.02.50.60.6-0.60.4-0.3-0.4-0.52.5-2.6
Reaction time premature initiations0.31.02.8-1.5-1.50.71.7-0.4-0.40.4-0.40.40.40.31.4-1.5
Std. dev. reaction times0.31.02.7-0.8-0.9-0.51.30.80.8-0.80.7-0.7-0.7-0.81.6-1.6
Reaction time trials completed0.41.42.30.20.31.0-1.2-1.4-1.41.4-1.21.01.21.1-1.51.5
Reaction time trials AUC0.31.01.70.10.20.8-0.9-1.3-1.31.3-1.00.91.00.9-1.21.2
Run reversals in cocaine runway, females3.23.65.5-0.1-0.1-1.71.42.32.3-2.31.9-1.9-2.0-2.12.0-2.3
Run reversals in cocaine runway, males0.10.10.20.50.5-0.1-0.30.30.3-0.3-0.00.10.00.0-0.40.3
Latency to leave start box in cocaine runway3.34.56.91.81.7-2.6-0.62.62.6-2.62.6-2.4-2.5-2.50.4-0.7
Latency to leave start box in cocaine runway, F4.55.68.71.61.4-2.80.03.03.0-3.02.9-2.7-2.8-2.81.0-1.5
Latency to leave start box in cocaine runway, M0.30.30.80.80.9-0.3-0.80.20.2-0.20.2-0.2-0.2-0.2-0.70.7
Std. dev. time between licks in bursts1.12.06.5-1.6-1.6-0.22.30.60.6-0.60.6-0.6-0.6-0.72.5-2.5
Total sessions with >9 infusions1.72.23.3-1.8-1.71.81.6-1.3-1.31.3-1.61.81.61.60.6-0.4
Short access day 1 total inactive lever presses0.00.10.40.20.30.20.10.20.2-0.2-0.20.60.30.3-0.20.1
Short access day 10 total inactive lever presses0.10.51.01.01.0-0.7-0.90.40.4-0.40.6-0.7-0.6-0.6-0.60.9
Short access day 1 total infusions1.42.86.0-2.4-2.41.82.2-1.1-1.11.1-1.61.71.61.51.3-1.3
Short access day 10 total infusions1.01.63.2-1.8-1.71.41.5-1.1-1.11.1-1.21.41.31.30.8-0.5
Short access total infusions1.72.44.3-1.7-1.61.91.5-1.3-1.31.3-1.82.11.81.80.4-0.5
Short access day 1 locomotion1.72.95.0-1.3-1.52.10.7-1.8-1.81.8-2.12.22.12.1-0.20.2
Short access day 10 total locomotion0.41.52.9-1.6-1.71.21.1-1.4-1.41.4-1.10.91.01.00.8-0.2
Short access total locomotion0.61.01.6-0.7-0.71.10.3-1.2-1.21.2-1.31.11.21.2-0.30.4
One hour access (0.3 mA shock)1.21.42.1-1.2-1.11.40.8-1.5-1.51.5-1.31.41.31.30.10.2
Compulsive drug intake0.81.14.41.31.20.1-2.1-0.6-0.60.6-0.30.30.40.4-1.81.6
One hour access (shock baseline)0.82.23.0-1.7-1.61.71.4-1.6-1.61.6-1.61.61.51.50.5-0.2
Social response proportion0.50.71.30.40.5-1.00.10.90.9-0.91.1-1.0-1.0-1.10.5-0.2
Social responses1.11.52.30.20.2-1.20.81.51.5-1.51.4-1.3-1.4-1.51.2-1.2
Social time1.32.15.52.32.3-1.3-1.81.11.1-1.11.0-1.0-1.0-1.0-1.51.3
Soleus weight1.44.06.5-0.2-0.3-1.91.72.12.1-2.12.1-2.2-2.2-2.32.4-2.5
Bone: stiffness0.50.91.30.80.8-1.1-0.21.11.1-1.11.1-1.1-1.1-1.00.3-0.3
Tibialis anterior weight0.20.71.8-0.6-0.6-0.51.10.70.7-0.70.7-0.7-0.7-0.61.3-1.3
Time to tail flick, vehicle, before self-admin0.30.30.7-0.4-0.40.60.1-0.8-0.80.8-0.60.50.60.6-0.10.3
Time to tail flick, vehicle, after self-admin0.71.42.4-1.3-1.01.50.9-1.1-1.11.1-1.41.51.41.50.1-0.3
Time to tail flick, test, before self-admin0.50.51.8-0.9-0.70.11.30.50.5-0.50.1-0.1-0.1-0.21.1-1.3
Time to tail flick, test, after self-admin0.60.61.6-0.6-0.6-0.31.30.70.7-0.70.5-0.4-0.5-0.51.3-1.3
Delta time to tail flick, vehicle, before/after SA0.40.41.0-0.7-0.60.90.7-0.3-0.30.3-0.81.00.80.90.1-0.5
Delta time to tail flick, test, before/after SA0.20.30.60.80.7-0.6-0.60.40.4-0.40.5-0.5-0.5-0.5-0.30.4
Tibia length1.85.17.6-1.8-1.82.70.4-2.8-2.82.8-2.72.72.72.6-0.60.8
Ambulatory time before self-admin0.20.71.31.21.1-0.9-1.10.50.5-0.50.8-0.9-0.8-0.7-0.60.8
Ambulatory time after self-admin1.42.26.60.91.01.0-1.6-1.2-1.21.2-1.41.31.31.4-2.22.6
Bone: tissue strength1.11.13.31.11.00.3-1.8-0.6-0.60.6-0.60.60.60.6-1.81.8
Total heroin consumption0.10.10.20.10.10.3-0.3-0.4-0.40.4-0.40.40.40.4-0.40.1
Bone: trabecular number0.61.13.11.71.6-0.7-1.80.30.3-0.30.4-0.5-0.5-0.6-1.41.5
Bone: trabecular spacing0.71.01.4-1.1-1.11.20.7-1.1-1.11.1-1.11.21.11.10.2-0.1
Bone: trabecular thickness0.40.60.90.80.7-1.0-0.50.80.8-0.80.8-1.0-0.9-0.9-0.0-0.0
Bone: trabecular tissue density1.93.35.11.01.1-2.20.02.22.2-2.22.1-2.3-2.2-2.20.9-1.0
Water consumed over 24 hours0.20.30.70.90.8-0.5-0.80.40.4-0.40.4-0.4-0.4-0.5-0.50.6
Number of responses in last shaping day0.81.01.40.20.1-1.00.61.21.2-1.21.2-1.1-1.1-1.11.0-1.0