Hub : Genes

P4ha3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression P4ha3 0.18 0.09 3.0e-14 0.13 0.12 0.12 0.12 5.6e-14 2.4e-13 5.4e-13 1.9e-13
2 IC gene expression P4ha3 0.21 0.11 3.2e-06 0.14 0.14 0.14 0.14 1.7e-06 1.8e-06 2.3e-06 2.0e-06
3 BLA gene expression P4ha3 0.08 0.06 1.2e-03 0.04 0.04 0.03 0.03 4.6e-03 4.4e-03 8.4e-03 1.2e-02
4 pVTA gene expression P4ha3 0.34 0.15 0.0e+00 0.18 0.23 0.23 0.24 1.5e-14 1.5e-18 3.3e-18 4.9e-19
5 Brain mRNA stability P4ha3 0.25 0.13 0.0e+00 0.26 0.25 0.25 0.26 7.6e-24 3.6e-23 2.5e-23 7.7e-24
6 IL mRNA stability P4ha3 0.24 0.15 4.0e-04 0.06 0.04 0.01 0.01 1.4e-02 3.4e-02 1.5e-01 1.4e-01
7 OFC mRNA stability P4ha3 0.38 0.18 2.0e-07 0.25 0.23 0.23 0.22 1.5e-06 3.4e-06 3.8e-06 5.2e-06
8 BLA mRNA stability P4ha3 0.27 0.14 4.1e-12 0.2 0.21 0.21 0.2 1.4e-10 3.5e-11 2.7e-11 4.5e-11
9 PL mRNA stability P4ha3 0.45 0.18 0.0e+00 0.29 0.31 0.31 0.29 5.5e-32 6.8e-34 6.9e-34 6.5e-32
10 IC mRNA stability P4ha3 0.26 0.12 2.2e-10 0.13 0.18 0.17 0.17 3.5e-06 6.8e-08 1.6e-07 1.7e-07
11 BLA intron excision ratio chr1_164041088_164046678 0.07 0.06 2.4e-03 0.03 0.03 0.02 0.02 9.3e-03 1.0e-02 2.0e-02 1.8e-02
12 NAcc gene expression P4ha3 0.23 0.13 0.0e+00 0.15 0.15 0.14 0.15 6.6e-22 5.6e-22 3.4e-21 1.0e-21
13 Brain gene expression P4ha3 0.23 0.13 2.7e-12 0.13 0.12 0.11 0.13 3.5e-12 1.2e-11 1.1e-10 8.9e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.31.1-0.7-0.7-0.1-1.00.30.30.30.10.00.10.1-0.9-1.0
Area under the delay curve0.10.20.30.30.3-0.40.1-0.4-0.4-0.4-0.4-0.5-0.40.50.50.6
BMI with tail0.72.34.70.80.9-1.11.8-1.5-1.5-1.5-1.3-1.3-1.31.42.22.2
BMI without tail0.92.88.21.61.7-0.52.6-1.3-1.3-1.3-1.0-0.9-1.01.12.92.7
Body weight1.04.310.31.41.5-1.22.8-1.9-1.9-1.9-1.6-1.6-1.71.73.23.2
Weight adjusted by age0.20.31.30.80.7-0.20.8-0.2-0.2-0.2-0.2-0.4-0.30.41.01.1
Bone surface0.40.61.41.21.10.80.90.80.80.80.80.70.7-0.40.60.4
Bone volume0.20.30.50.70.70.60.50.60.60.60.60.40.5-0.30.30.2
Breakpoint value in progressive ratio session0.60.72.2-1.3-1.3-0.5-1.5-0.2-0.2-0.2-0.2-0.3-0.20.1-1.3-1.1
Number of licking bursts3.35.37.9-2.3-2.3-2.8-1.2-2.6-2.6-2.6-2.7-2.7-2.72.7-0.00.1
Context. condit. distance diff. score2.42.94.51.51.52.10.62.02.02.02.02.12.0-2.1-0.2-0.2
Locomotion velocity, session 10.50.51.7-0.7-0.70.2-1.10.40.40.40.40.30.4-0.4-1.2-1.3
Locomotion distance, session 11.01.32.00.80.81.40.11.41.41.41.41.31.4-1.4-0.4-0.5
Locomotion velocity, session 20.00.10.10.40.40.10.40.10.10.10.10.10.1-0.00.30.3
Locomotion distance, session 20.50.71.10.80.81.00.31.01.01.00.90.90.9-1.0-0.1-0.2
Locomotion velocity, session 31.11.31.90.60.61.3-0.21.41.41.41.31.31.3-1.3-0.7-0.8
Locomotion distance, session 31.92.13.20.70.71.7-0.31.81.81.81.81.71.7-1.7-0.9-1.0
Stereotopy head waving bouts, day 30.70.81.2-0.5-0.5-1.00.2-1.1-1.1-1.1-1.1-1.0-1.11.10.60.6
Stereotopy head waving duration, day 30.10.20.30.20.20.50.00.40.40.40.50.50.5-0.5-0.2-0.2
Locomotion velocity, session 70.20.20.6-0.6-0.6-0.1-0.7-0.1-0.1-0.1-0.1-0.0-0.0-0.0-0.7-0.8
Locomotion distance, session 70.10.10.2-0.5-0.5-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.40.4-0.1-0.2
Stereotopy head waving bouts, day 72.73.04.51.71.72.10.72.02.02.02.02.02.0-2.1-0.1-0.1
Stereotopy head waving duration, day 72.63.14.52.02.02.11.21.91.91.92.02.02.0-2.00.40.3
Locomotion velocity, session 80.70.81.20.90.91.10.51.11.11.11.01.01.0-1.10.0-0.1
Locomotion distance, session 82.23.14.81.81.82.10.92.02.02.01.92.12.0-2.20.10.0
Degree of sensitization distance2.42.53.5-0.3-0.3-1.60.9-1.9-1.9-1.9-1.8-1.8-1.81.81.51.6
Degree of sensitization stereotypy5.25.78.32.52.52.91.22.72.72.72.72.72.7-2.80.10.0
Conditioned locomotion0.20.30.7-0.5-0.50.2-0.70.40.40.40.30.30.3-0.4-0.8-0.9
Cocaine response after cond. corrected2.02.33.4-1.3-1.3-1.9-0.4-1.8-1.8-1.8-1.8-1.8-1.81.80.30.6
Cocaine response after cond. not corrected0.50.50.8-0.7-0.8-0.9-0.3-0.9-0.9-0.9-0.8-0.8-0.80.80.10.3
Cocaine response before conditioning2.42.94.41.21.22.10.22.02.02.02.12.12.1-2.0-0.6-0.7
Saline control response1.01.33.01.71.71.11.60.80.80.80.80.90.8-0.81.11.2
Bone: connectivity density0.30.51.3-0.4-0.30.4-0.80.70.70.70.60.50.5-0.4-0.9-1.1
Bone: cortical apparent density1.62.23.5-1.5-1.5-1.9-0.8-1.6-1.6-1.6-1.7-1.8-1.81.7-0.1-0.1
Bone: cortical area0.20.20.80.70.6-0.00.9-0.1-0.1-0.1-0.1-0.2-0.20.30.90.8
Bone: cortical porosity1.21.31.90.40.41.2-0.31.41.41.41.31.41.3-1.4-0.8-0.9
Bone: cortical porosity1.31.42.10.50.51.3-0.21.41.41.41.31.41.4-1.5-0.7-0.9
Bone: cortical thickness0.20.30.8-0.8-0.9-0.6-0.8-0.3-0.3-0.3-0.5-0.5-0.50.4-0.5-0.7
Bone: cortical thickness0.20.20.50.40.30.50.10.70.70.70.50.40.5-0.4-0.1-0.3
Bone: cortical tissue density1.52.13.2-1.6-1.5-1.8-1.0-1.5-1.5-1.5-1.6-1.7-1.71.7-0.2-0.2
Condit. Reinf. active minus inactive responses0.30.30.90.60.6-0.10.9-0.3-0.3-0.3-0.2-0.3-0.30.30.90.9
Condit. Reinf. active-inactive response ratio0.50.51.61.01.00.11.2-0.1-0.1-0.1-0.1-0.1-0.10.11.21.2
Condit. Reinf. active responses0.10.10.30.20.2-0.20.4-0.4-0.4-0.4-0.3-0.3-0.30.30.50.5
Condit. Reinf. inactive responses0.00.00.1-0.3-0.3-0.0-0.3-0.0-0.0-0.00.00.00.0-0.0-0.3-0.3
Incentive salience index mean0.20.30.80.70.70.00.9-0.1-0.1-0.1-0.1-0.1-0.10.20.90.8
Condit. Reinf. lever presses0.10.20.40.70.70.30.60.30.30.30.30.20.2-0.20.50.3
Condit. Reinf. active minus inactive responses4.45.613.63.73.72.23.31.71.71.71.81.71.7-1.62.42.1
Condit. Reinf. active-inactive response ratio1.01.12.61.61.61.11.30.90.90.90.90.90.9-0.80.90.7
Condit. Reinf. active responses5.78.019.64.44.42.54.11.91.91.91.91.81.9-1.63.12.8
Condit. Reinf. inactive responses3.14.09.93.13.11.63.01.21.21.21.21.21.2-1.02.42.3
Condit. Reinf. lever presses11.215.431.95.65.64.24.73.43.43.43.53.53.5-3.23.02.5
Condit. Reinf. lever reinforcers received6.59.121.94.74.72.84.22.12.12.12.22.12.1-1.93.12.8
Conditioned reinforcement - actives1.42.43.31.31.41.80.51.81.81.81.81.81.8-1.8-0.2-0.5
Conditioned reinforcement - inactives0.10.20.5-0.7-0.7-0.2-0.6-0.3-0.3-0.3-0.10.0-0.10.1-0.5-0.5
Conditioned locomotion3.64.77.31.21.22.5-0.02.62.62.62.72.62.6-2.7-1.1-1.5
Patch foraging indifference point 0 sec2.34.37.72.62.82.41.82.12.12.12.12.12.1-2.11.01.1
Patch foraging indifference point AUC0.40.61.70.50.6-0.51.0-0.5-0.5-0.5-0.7-0.7-0.70.81.31.3
Delay disc. indifference point, 0s delay0.80.82.11.51.50.81.20.60.60.60.70.60.7-0.70.90.9
Delay disc. indifference point, 16s delay0.00.00.2-0.1-0.2-0.2-0.4-0.0-0.0-0.0-0.1-0.1-0.10.2-0.2-0.2
Delay disc. indifference point, 2s delay0.60.72.01.31.40.21.3-0.2-0.2-0.2-0.0-0.1-0.00.31.41.4
Delay disc. indifference point, 24s delay0.60.71.1-1.0-1.0-1.0-1.0-0.7-0.7-0.7-0.8-0.9-0.81.1-0.5-0.5
Delay disc. indifference point, 4s delay1.11.13.31.61.60.11.7-0.1-0.1-0.1-0.2-0.2-0.20.41.81.7
Delay disc. indifference point, 8s delay0.10.10.20.30.4-0.2-0.0-0.1-0.1-0.1-0.2-0.2-0.20.10.40.5
Indifference point function ln k1.73.04.50.90.92.0-0.42.12.12.12.12.02.1-2.1-1.2-1.3
Indifference point function log k1.73.04.50.90.92.0-0.42.12.12.12.12.02.1-2.1-1.2-1.3
Patch foraging total patch changes 0 sec1.83.56.82.52.62.11.81.81.81.81.81.81.8-1.81.01.1
Patch foraging total patch changes 12 sec0.91.23.31.61.70.21.80.10.10.1-0.1-0.1-0.10.11.81.8
Patch foraging total patch changes 18 sec1.32.04.92.12.21.32.00.90.90.91.01.01.0-0.91.51.6
Patch foraging total patch changes 24 sec0.50.92.91.51.50.31.7-0.0-0.0-0.00.00.10.00.11.61.4
Patch foraging total patch changes 6 sec0.50.81.61.21.30.90.81.01.01.00.70.70.8-0.70.50.4
Patch foraging time to switch 0 sec1.73.57.5-2.7-2.7-1.9-2.0-1.6-1.6-1.6-1.6-1.6-1.61.5-1.5-1.5
Patch foraging water rate 0 sec1.73.66.32.52.52.21.61.91.91.91.91.91.9-1.80.90.8
Patch foraging water rate 12 sec1.42.94.31.71.62.10.72.02.02.02.02.12.0-1.8-0.1-0.3
Patch foraging water rate 18 sec0.61.02.31.51.41.11.20.90.90.90.90.90.9-0.80.80.4
Patch foraging water rate 24 sec1.92.64.50.90.81.8-0.22.12.12.11.91.81.9-1.8-0.9-1.2
Patch foraging water rate 6 sec1.11.52.50.80.91.50.21.51.51.51.51.61.5-1.4-0.3-0.6
Seeking ratio, delayed vs. immediate footshock1.01.23.6-1.8-1.9-0.6-1.5-0.7-0.7-0.7-0.4-0.2-0.40.2-1.5-1.2
Distance traveled before self-admin0.60.81.4-1.0-0.9-1.1-0.7-0.8-0.8-0.8-1.1-1.2-1.11.0-0.1-0.1
Distance traveled after self-admin1.11.44.4-1.4-1.40.3-1.80.50.50.50.60.50.5-0.6-2.0-2.1
Extensor digitorum longus weight0.52.02.80.00.1-1.41.1-1.5-1.5-1.5-1.6-1.6-1.61.51.61.7
Bone: elastic displacement1.31.53.9-2.0-1.9-1.0-2.0-0.6-0.6-0.6-0.7-0.7-0.70.7-1.5-1.4
Bone: elastic work1.31.64.4-2.0-2.0-0.9-2.1-0.4-0.4-0.4-0.6-0.6-0.60.5-1.7-1.7
Bone: endosteal estimation1.02.27.02.22.10.52.60.00.00.00.10.10.10.22.42.4
Bone: endosteal perimeter1.12.47.42.52.40.82.70.30.30.30.40.30.4-0.12.32.4
Epididymis fat weight0.31.22.2-0.9-0.8-1.3-0.2-1.5-1.5-1.5-1.2-1.2-1.21.20.30.6
Delta time in closed arm before/after self-admin3.43.25.2-0.8-0.8-2.00.4-2.3-2.3-2.3-2.2-2.1-2.12.11.21.2
Delta time in open arm before/after self-admin1.61.63.01.71.71.41.51.01.01.01.31.31.2-1.20.91.1
Diff in mean of infusions in LGA sessions3.54.38.2-2.6-2.9-2.3-2.0-2.1-2.1-2.1-2.0-1.9-2.01.9-1.2-1.2
Delay discount exponential model param0.20.20.4-0.3-0.30.4-0.10.40.40.40.40.50.4-0.6-0.5-0.6
Extinction: sum of active levers before priming0.10.10.30.10.1-0.10.4-0.4-0.4-0.4-0.1-0.1-0.10.10.40.6
Active lever presses in extinction session 64.54.56.90.50.62.3-1.12.62.62.62.52.42.5-2.6-1.8-1.6
Bone: final force0.00.10.2-0.4-0.4-0.3-0.3-0.2-0.2-0.2-0.3-0.3-0.30.3-0.1-0.1
Bone: final moment0.00.00.0-0.2-0.1-0.2-0.1-0.0-0.0-0.0-0.2-0.1-0.20.2-0.00.0
Food consumed during 24 hour testing period2.94.06.02.02.02.41.02.32.32.32.32.32.3-2.20.1-0.1
Glucose0.00.00.1-0.0-0.0-0.20.0-0.1-0.1-0.1-0.2-0.3-0.20.30.1-0.0
Heart weight0.71.11.71.21.21.20.81.11.11.11.11.21.1-1.30.30.1
Delay discount hyperbolic model param0.30.30.7-0.5-0.50.4-0.40.50.50.50.50.60.5-0.7-0.8-0.9
Intermittent access intake day 1-15 change0.51.02.30.70.71.00.11.51.51.51.00.91.0-0.9-0.3-0.4
Intermittent access intake escalation0.61.32.70.80.81.20.21.61.61.61.21.11.2-1.1-0.3-0.5
Intermittent access intake escalation 20.70.71.61.01.00.90.51.31.31.30.70.60.7-0.70.3-0.1
Intermitt. access day 1 inactive lever presses0.41.52.0-1.3-1.3-1.4-0.6-1.4-1.4-1.4-1.4-1.2-1.31.3-0.1-0.3
Intermitt. access day 15 inactive lever presses0.30.61.8-1.4-1.3-0.3-1.2-0.1-0.1-0.1-0.1-0.0-0.1-0.0-1.3-1.3
Intermitt. access escalation Index0.00.00.10.40.30.10.20.10.10.10.1-0.00.1-0.00.2-0.1
Intermittent access day 1 total infusions1.11.73.41.21.11.70.81.21.21.21.61.81.6-1.7-0.1-0.2
Intermittent access day 15 total infusions1.62.43.61.31.31.90.51.91.91.91.91.91.8-1.8-0.3-0.6
Intermittent access terminal intake (last 3 days)2.02.73.81.71.71.90.82.02.02.01.91.81.8-1.80.1-0.2
Intermittent access total infusions1.51.82.91.51.41.71.11.31.31.31.61.71.5-1.50.30.1
Intermittent access day 1 locomotion0.50.71.20.20.20.9-0.00.90.90.91.11.11.0-1.1-0.6-0.8
Intermittent access day 15 total locomotion1.32.33.90.70.71.7-0.12.02.02.01.81.81.7-1.8-0.9-1.0
Intermittent access total locomotion1.01.22.30.70.71.40.31.31.31.31.41.51.4-1.4-0.4-0.5
Intermittent access standard deviation0.20.41.10.80.9-0.21.0-0.0-0.0-0.0-0.4-0.5-0.30.41.01.0
Left kidney weight0.41.95.51.31.3-0.62.0-0.9-0.9-0.9-1.0-1.0-1.01.02.32.3
Right kidney weight0.62.77.91.61.6-0.72.5-1.1-1.1-1.1-1.1-1.1-1.11.22.82.7
Cocaine induced anxiety0.91.32.6-1.6-1.6-1.3-1.4-0.9-0.9-0.9-1.1-1.2-1.11.1-0.7-0.6
Post-drug Anxiety1.71.82.8-1.7-1.6-1.6-1.2-1.3-1.3-1.3-1.4-1.4-1.41.4-0.5-0.5
Baseline Anxiety0.10.10.30.50.60.20.6-0.2-0.2-0.20.20.30.1-0.10.50.5
Tail length1.04.011.82.02.0-0.73.1-1.4-1.4-1.4-1.2-1.2-1.21.23.43.3
Length with tail0.62.77.81.51.4-0.62.6-1.3-1.3-1.3-0.9-0.9-1.01.02.72.8
Length without tail0.10.30.5-0.4-0.5-0.60.0-0.7-0.7-0.7-0.6-0.5-0.60.60.10.3
Times rat made contact with spout0.80.91.6-0.2-0.2-1.10.3-1.1-1.1-1.1-1.1-1.2-1.21.30.90.8
Lifetime Intake1.82.23.91.51.51.91.21.41.41.41.82.01.8-1.70.20.1
Liver weight, left0.81.32.30.30.2-1.01.1-1.2-1.2-1.2-1.2-1.2-1.21.31.51.4
Liver weight, right2.13.75.4-0.4-0.5-2.10.9-2.3-2.3-2.3-2.3-2.2-2.32.31.71.8
Locomotor activity0.60.91.51.21.21.00.41.21.21.20.80.70.9-0.90.30.1
Locomotor testing distance1.01.84.72.22.21.11.71.11.11.10.90.80.9-0.81.41.1
Locomotor testing rearing0.50.92.81.31.40.01.60.00.00.0-0.3-0.3-0.30.31.71.6
Locomotion in novel chamber1.21.53.00.60.71.2-0.41.71.71.71.21.01.3-1.4-0.7-1.0
Locomotion in novel chamber post-restriction1.62.64.01.41.51.90.71.91.91.91.91.91.9-2.0-0.1-0.4
Fecal boli incidents, locomotor time 10.91.32.20.50.51.3-0.21.31.31.31.51.41.4-1.5-0.8-0.9
Change in fecal boli incidents, locomotor task0.70.71.0-0.9-1.0-1.0-0.4-0.9-0.9-0.9-1.0-0.9-0.91.0-0.1-0.3
Time >=10cm from walls, locomotor time 12.12.33.31.31.31.80.51.81.81.81.81.81.8-1.8-0.2-0.3
Bouts of movement, locomotor time 10.20.20.40.30.30.60.30.40.40.40.60.50.5-0.5-0.0-0.0
Total resting periods, locomotor time 10.40.40.8-0.1-0.20.7-0.20.60.60.60.90.80.8-0.8-0.8-0.7
Rest time, locomotor task time 10.50.61.5-0.7-0.80.5-0.80.50.50.50.60.70.6-0.8-1.2-1.1
Distance moved, locomotor task time 10.50.82.00.80.7-0.61.0-0.5-0.5-0.5-0.8-0.9-0.81.01.41.4
Vertical activity count, locomotor time 10.20.51.61.01.0-0.11.0-0.2-0.2-0.2-0.4-0.2-0.30.31.31.1
Time >=10cm from walls, locomotor time 20.81.22.41.51.51.11.31.01.01.00.91.01.0-1.00.80.7
Bouts of movement, locomotor time 20.40.62.30.90.9-0.21.5-0.3-0.3-0.3-0.3-0.5-0.40.61.41.1
Total resting periods, locomotor time 20.30.51.30.50.5-0.41.1-0.5-0.5-0.5-0.6-0.7-0.60.71.10.9
Rest time, locomotor task time 21.82.24.9-2.2-2.2-1.6-1.7-1.3-1.3-1.3-1.5-1.2-1.31.2-1.1-0.9
Distance moved, locomotor task time 21.92.25.42.32.31.41.91.21.21.21.11.11.1-0.91.41.4
Vertical activity count, locomotor time 20.71.02.81.71.60.61.50.40.40.40.30.40.4-0.31.41.2
Light reinforcement 11.23.04.6-2.1-2.1-2.0-1.4-1.9-1.9-1.9-1.8-1.8-1.81.8-0.60.0
Light reinforcement 20.20.31.1-0.9-0.8-0.2-1.10.10.10.10.00.00.0-0.1-0.9-0.6
Bone: marrow area0.92.06.32.12.00.32.5-0.1-0.1-0.1-0.0-0.1-0.10.32.32.4
Bone: maximum diameter0.91.74.82.12.00.82.20.50.50.50.50.50.5-0.41.81.8
Bone: maximum force0.00.00.1-0.2-0.2-0.2-0.2-0.0-0.0-0.0-0.1-0.1-0.10.1-0.10.0
Bone: maximum moment0.00.00.00.00.1-0.00.00.10.10.1-0.0-0.0-0.00.00.10.1
Mean time between licks in bursts1.53.710.82.92.90.83.30.30.30.30.30.40.3-0.23.03.1
Mean num. licks in bursts2.64.16.02.12.22.41.22.32.32.32.32.32.3-2.20.30.2
Cd content in liver0.70.81.2-0.4-0.3-1.00.3-1.1-1.1-1.1-1.1-1.0-1.11.00.70.8
Co content in liver0.80.92.61.51.50.61.60.20.20.20.30.30.3-0.31.41.4
Cu content in liver1.11.34.11.01.1-0.41.7-0.8-0.8-0.8-0.8-0.7-0.70.61.92.0
Fe content in liver0.00.00.1-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.1-0.0-0.10.0
K content in liver0.40.40.6-0.1-0.1-0.70.4-0.7-0.7-0.7-0.8-0.7-0.70.70.60.6
Mg content in liver0.10.10.20.40.40.20.40.10.10.10.10.10.1-0.20.30.3
Mn content in liver0.80.92.8-1.4-1.4-0.3-1.70.00.00.0-0.0-0.0-0.0-0.0-1.6-1.6
Na content in liver0.40.40.60.80.70.80.50.60.60.60.70.70.7-0.70.20.2
Rb content in liver0.20.20.50.70.70.50.50.40.40.40.40.50.5-0.50.30.3
Se content in liver2.93.48.0-2.8-2.8-1.8-2.5-1.4-1.4-1.4-1.5-1.4-1.41.2-1.8-1.7
Sr content in liver0.30.30.40.10.10.6-0.30.60.60.60.60.60.6-0.6-0.5-0.6
Zn content in liver1.71.94.72.22.21.22.10.80.80.80.80.90.9-0.81.61.6
Bone: minimum diameter1.12.15.61.31.2-0.62.2-1.0-1.0-1.0-0.9-1.0-1.01.12.42.4
Time in familiar zone, hab. session 10.20.20.30.10.1-0.30.4-0.4-0.4-0.4-0.4-0.4-0.40.40.60.5
Time in novel zone, hab. session 10.20.20.3-0.5-0.5-0.5-0.3-0.4-0.4-0.4-0.4-0.5-0.50.4-0.2-0.0
Total zone transitions, hab. session 10.40.51.2-0.3-0.30.6-0.70.80.80.80.70.70.7-0.8-1.0-1.1
Total locomotion distance, hab. session 11.62.23.2-0.4-0.4-1.70.6-1.8-1.8-1.8-1.8-1.8-1.81.71.31.3
Locomotion velocity, hab. session 10.91.31.8-0.3-0.3-1.20.5-1.3-1.3-1.3-1.4-1.4-1.41.21.01.1
Time in familiar zone, hab. session 21.01.12.31.51.51.01.40.80.80.80.80.90.8-0.91.00.8
Time in novel zone, hab. session 20.30.30.8-0.8-0.8-0.3-0.9-0.2-0.2-0.2-0.2-0.2-0.20.3-0.8-0.6
Total zone transitions, hab. session 21.62.13.21.01.01.70.21.71.71.71.71.71.7-1.8-0.5-0.6
Total locomotion distance, hab. session 20.91.12.50.50.5-0.81.2-1.0-1.0-1.0-1.0-1.0-1.00.91.51.6
Locomotion velocity, hab. session 21.21.53.10.40.4-1.01.3-1.3-1.3-1.3-1.3-1.2-1.21.21.71.8
Novel to familiar place preference ratio0.00.00.10.20.20.30.10.20.20.20.30.30.3-0.3-0.00.1
Novelty place preference0.00.00.10.20.20.30.10.20.20.20.30.30.3-0.3-0.00.1
Time in novel zone, NPP test0.10.20.30.40.40.50.20.40.40.40.50.50.5-0.5-0.00.1
Total zone transitions, NPP test0.40.60.90.20.20.8-0.30.90.90.90.90.80.9-1.0-0.6-0.7
Total locomotion distance, NPP test1.11.42.1-0.2-0.2-1.30.7-1.4-1.4-1.4-1.4-1.4-1.41.41.11.2
Locomotion velocity, NPP test1.31.92.8-0.5-0.5-1.60.4-1.6-1.6-1.6-1.7-1.7-1.71.61.01.1
Intraocular pressure0.40.61.2-0.00.00.8-0.51.11.11.10.90.80.8-0.7-0.8-0.9
Delta distance traveled before/after self-admin2.42.54.20.70.61.9-0.01.81.81.82.02.12.0-2.0-1.0-1.3
Delta ambulatory time before/after self-admin2.12.64.50.60.62.0-0.11.81.81.82.12.12.0-2.0-1.1-1.4
Parametrial fat weight0.71.62.6-1.2-1.2-1.4-0.4-1.6-1.6-1.6-1.3-1.3-1.41.40.10.5
Pavlov. Cond. lever latency1.01.32.7-1.6-1.6-1.2-1.3-1.0-1.0-1.0-1.0-1.0-1.01.0-0.9-0.7
Pavlov. Cond. magazine entry latency2.22.85.82.42.41.82.01.41.41.41.51.51.5-1.41.31.2
Pavlov. Cond. change in total contacts1.01.12.21.51.51.11.20.90.90.90.90.90.9-0.90.80.7
Pavlov. Cond. index score1.92.45.22.32.31.61.91.31.31.31.31.31.3-1.31.31.1
Pavlov. Cond. latency score1.82.34.92.22.21.61.81.31.31.31.41.31.3-1.31.21.0
Pavlov. Cond. lever contacts0.91.12.51.61.61.01.40.80.80.80.80.80.8-0.81.00.8
Pavlov. Cond. magazine entry number2.32.95.9-2.4-2.4-1.8-2.0-1.5-1.5-1.5-1.5-1.5-1.51.5-1.3-1.1
Pavlov. Cond. intertrial magazine entries0.60.81.7-1.3-1.3-0.8-1.2-0.7-0.7-0.7-0.7-0.7-0.70.6-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.1.51.94.12.02.01.41.71.11.11.11.21.21.2-1.21.10.9
Pavlov. Cond. response bias1.01.32.81.71.71.21.40.90.90.91.01.01.0-0.90.90.8
Pavlov. Cond. lever latency12.617.133.0-5.7-5.7-4.5-4.4-4.0-4.0-4.0-3.9-3.9-3.93.7-2.6-2.1
Pavlov. Cond. magazine entry latency3.44.26.02.42.32.41.42.22.22.22.22.32.3-2.10.50.2
Pavlov. Cond. change in total contacts8.213.124.34.94.94.03.73.53.53.53.53.53.5-3.42.11.6
Pavlov. Cond. index score9.412.723.74.94.84.03.63.53.53.53.43.53.5-3.32.11.6
Pavlov. Cond. latency score8.511.220.34.54.43.83.33.33.33.33.33.33.3-3.11.81.4
Pavlov. Cond. lever contacts11.716.131.45.65.54.44.43.83.83.83.73.73.7-3.52.62.1
Pavlov. Cond. magazine entry number5.87.210.2-3.2-3.1-3.2-2.0-2.9-2.9-2.9-2.9-2.9-2.92.8-0.7-0.5
Pavlov. Cond. intertrial magazine entries0.81.22.90.60.6-0.81.3-1.0-1.0-1.0-0.9-1.0-1.00.91.61.7
Pavlov. Cond. lever-magazine prob. diff.8.711.622.44.74.73.83.63.23.23.23.23.23.2-3.12.11.7
Pavlov. Cond. response bias12.416.931.25.65.54.64.24.04.04.04.04.04.0-3.82.41.9
Time in closed arm before self-admin2.83.55.60.90.92.2-0.32.42.42.42.22.22.2-2.2-1.1-1.3
Time in closed arm after self-admin0.60.62.3-1.1-1.2-0.4-1.20.10.10.1-0.2-0.2-0.20.1-1.2-1.5
Time in open arm before self-admin2.93.24.9-1.8-1.6-2.2-1.2-1.9-1.9-1.9-2.1-2.2-2.12.1-0.00.1
Time in open arm after self-admin0.60.62.50.50.6-0.40.9-0.7-0.7-0.7-0.5-0.5-0.60.61.21.6
Bone: periosteal estimation0.71.55.01.91.80.42.20.00.00.00.1-0.0-0.00.22.02.0
Bone: periosteal perimeter0.81.44.31.81.70.52.10.10.10.10.20.10.10.11.81.9
Bone: post-yield work0.00.00.20.30.30.10.3-0.0-0.0-0.00.00.00.0-0.00.30.4
Progressive ratio test 1 active lever presses0.30.41.0-0.4-0.50.4-0.50.40.40.40.60.70.6-0.6-0.9-1.0
Progressive ratio test 1 breakpoint0.30.30.9-0.4-0.50.4-0.40.30.30.30.60.70.5-0.6-0.8-1.0
Progressive ratio test 1 inactive lever presses0.20.30.6-0.6-0.70.3-0.5-0.1-0.1-0.10.40.70.5-0.5-0.8-0.7
Progressive ratio test 2 active lever presses0.30.40.90.90.90.60.60.60.60.60.60.60.6-0.60.50.2
Progressive ratio test 2 breakpoint0.40.40.90.90.90.70.60.60.60.60.60.70.6-0.60.50.2
Progressive ratio test 2 inactive lever presses0.40.61.30.30.40.9-0.00.80.80.81.01.11.0-1.1-0.4-0.4
Incentive Sensitization - Responses0.60.82.21.51.50.70.90.80.80.80.50.50.5-0.51.00.8
Incentive Sensitization - Breakpoint0.60.71.91.41.40.70.80.80.80.80.50.50.6-0.50.80.7
Sum of active levers in priming session hrs 5-60.10.10.3-0.2-0.20.2-0.60.50.50.50.30.20.3-0.3-0.5-0.1
Progressive ratio0.50.71.30.40.40.9-0.11.11.11.11.01.00.9-1.1-0.4-0.3
Food seeking constrained by brief footshock0.91.12.81.71.60.51.70.40.40.40.30.10.2-0.11.61.6
Seeking ratio, punishment vs. effort0.91.33.41.21.0-0.41.8-0.9-0.9-0.9-0.7-0.7-0.70.91.81.8
Retroperitoneal fat weight3.313.921.9-1.7-1.6-4.20.8-4.7-4.7-4.7-4.4-4.4-4.44.42.42.9
Reaction time number correct0.71.42.2-0.2-0.31.0-1.11.41.41.41.21.01.2-1.1-1.5-1.5
Reaction time mean minus median0.20.61.61.21.30.61.10.30.30.30.50.50.4-0.31.01.1
Reaction time mean minus median AUC0.41.01.51.21.21.20.81.01.01.01.21.11.1-1.10.40.5
Reaction time num false alarms1.82.64.0-1.3-1.3-2.0-0.6-1.9-1.9-1.9-2.0-2.0-1.91.80.30.4
Reaction time num false alarms AUC0.81.21.8-0.9-0.9-1.4-0.5-1.3-1.3-1.3-1.3-1.4-1.31.10.10.2
Reaction time trials correct on left0.71.42.2-0.2-0.31.0-1.11.41.41.41.21.01.2-1.1-1.5-1.5
Reaction time trials on left0.71.42.3-0.2-0.31.0-1.21.41.41.41.21.01.2-1.1-1.5-1.5
Reaction time mean0.91.42.6-0.9-0.8-1.3-0.3-1.6-1.6-1.6-1.3-1.2-1.31.30.40.7
Reaction time mean AUC0.91.52.7-1.3-1.2-1.3-0.7-1.6-1.6-1.6-1.2-1.2-1.31.3-0.00.2
Median of all reaction times1.42.03.5-1.4-1.3-1.6-0.9-1.9-1.9-1.9-1.5-1.4-1.51.5-0.00.3
Reaction time omissions0.30.50.8-0.0-0.0-0.70.4-0.9-0.9-0.9-0.8-0.7-0.70.70.70.9
Reaction time false alarm rate1.72.33.8-0.8-0.8-1.8-0.1-2.0-2.0-2.0-1.9-1.8-1.81.70.70.7
Reaction time premature initiation rate1.52.16.81.71.8-0.02.5-0.6-0.6-0.6-0.4-0.3-0.40.52.52.6
Reaction time premature initiations0.61.02.81.51.50.71.70.40.40.40.40.40.4-0.31.41.5
Std. dev. reaction times0.51.02.70.80.9-0.51.3-0.8-0.8-0.8-0.7-0.7-0.70.81.61.6
Reaction time trials completed0.71.42.3-0.2-0.31.0-1.21.41.41.41.21.01.2-1.1-1.5-1.5
Reaction time trials AUC0.51.01.7-0.1-0.20.8-0.91.31.31.31.00.91.0-0.9-1.2-1.2
Run reversals in cocaine runway, females3.63.65.50.10.1-1.71.4-2.3-2.3-2.3-1.9-1.9-2.02.12.02.3
Run reversals in cocaine runway, males0.10.10.2-0.5-0.5-0.1-0.3-0.3-0.3-0.30.00.10.0-0.0-0.4-0.3
Latency to leave start box in cocaine runway4.04.56.9-1.8-1.7-2.6-0.6-2.6-2.6-2.6-2.6-2.4-2.52.50.40.7
Latency to leave start box in cocaine runway, F4.95.68.7-1.6-1.4-2.80.0-3.0-3.0-3.0-2.9-2.7-2.82.81.01.5
Latency to leave start box in cocaine runway, M0.30.30.8-0.8-0.9-0.3-0.8-0.2-0.2-0.2-0.2-0.2-0.20.2-0.7-0.7
Std. dev. time between licks in bursts1.52.06.51.61.6-0.22.3-0.6-0.6-0.6-0.6-0.6-0.60.72.52.5
Total sessions with >9 infusions1.82.23.31.81.71.81.61.31.31.31.61.81.6-1.60.60.4
Short access day 1 total inactive lever presses0.10.10.4-0.2-0.30.20.1-0.2-0.2-0.20.20.60.3-0.3-0.2-0.1
Short access day 10 total inactive lever presses0.20.51.0-1.0-1.0-0.7-0.9-0.4-0.4-0.4-0.6-0.7-0.60.6-0.6-0.9
Short access day 1 total infusions2.12.86.02.42.41.82.21.11.11.11.61.71.6-1.51.31.3
Short access day 10 total infusions1.31.63.21.81.71.41.51.11.11.11.21.41.3-1.30.80.5
Short access total infusions1.92.44.31.71.61.91.51.31.31.31.82.11.8-1.80.40.5
Short access day 1 locomotion2.32.95.01.31.52.10.71.81.81.82.12.22.1-2.1-0.2-0.2
Short access day 10 total locomotion0.81.52.91.61.71.21.11.41.41.41.10.91.0-1.00.80.2
Short access total locomotion0.81.01.60.70.71.10.31.21.21.21.31.11.2-1.2-0.3-0.4
One hour access (0.3 mA shock)1.31.42.11.21.11.40.81.51.51.51.31.41.3-1.30.1-0.2
Compulsive drug intake0.91.14.4-1.3-1.20.1-2.10.60.60.60.30.30.4-0.4-1.8-1.6
One hour access (shock baseline)1.42.23.01.71.61.71.41.61.61.61.61.61.5-1.50.50.2
Social response proportion0.60.71.3-0.4-0.5-1.00.1-0.9-0.9-0.9-1.1-1.0-1.01.10.50.2
Social responses1.21.52.3-0.2-0.2-1.20.8-1.5-1.5-1.5-1.4-1.3-1.41.51.21.2
Social time1.52.15.5-2.3-2.3-1.3-1.8-1.1-1.1-1.1-1.0-1.0-1.01.0-1.5-1.3
Soleus weight1.44.06.50.20.3-1.91.7-2.1-2.1-2.1-2.1-2.2-2.22.32.42.5
Bone: stiffness0.50.91.3-0.8-0.8-1.1-0.2-1.1-1.1-1.1-1.1-1.1-1.11.00.30.3
Tibialis anterior weight0.20.71.80.60.6-0.51.1-0.7-0.7-0.7-0.7-0.7-0.70.61.31.3
Time to tail flick, vehicle, before self-admin0.30.30.70.40.40.60.10.80.80.80.60.50.6-0.6-0.1-0.3
Time to tail flick, vehicle, after self-admin1.01.42.41.31.01.50.91.11.11.11.41.51.4-1.50.10.3
Time to tail flick, test, before self-admin0.50.51.80.90.70.11.3-0.5-0.5-0.5-0.1-0.1-0.10.21.11.3
Time to tail flick, test, after self-admin0.60.61.60.60.6-0.31.3-0.7-0.7-0.7-0.5-0.4-0.50.51.31.3
Delta time to tail flick, vehicle, before/after SA0.50.41.00.70.60.90.70.30.30.30.81.00.8-0.90.10.5
Delta time to tail flick, test, before/after SA0.30.30.6-0.8-0.7-0.6-0.6-0.4-0.4-0.4-0.5-0.5-0.50.5-0.3-0.4
Tibia length1.95.17.61.81.82.70.42.82.82.82.72.72.7-2.6-0.6-0.8
Ambulatory time before self-admin0.50.71.3-1.2-1.1-0.9-1.1-0.5-0.5-0.5-0.8-0.9-0.80.7-0.6-0.8
Ambulatory time after self-admin1.92.26.6-0.9-1.01.0-1.61.21.21.21.41.31.3-1.4-2.2-2.6
Bone: tissue strength1.11.13.3-1.1-1.00.3-1.80.60.60.60.60.60.6-0.6-1.8-1.8
Total heroin consumption0.10.10.2-0.1-0.10.3-0.30.40.40.40.40.40.4-0.4-0.4-0.1
Bone: trabecular number0.71.13.1-1.7-1.6-0.7-1.8-0.3-0.3-0.3-0.4-0.5-0.50.6-1.4-1.5
Bone: trabecular spacing0.71.01.41.11.11.20.71.11.11.11.11.21.1-1.10.20.1
Bone: trabecular thickness0.50.60.9-0.8-0.7-1.0-0.5-0.8-0.8-0.8-0.8-1.0-0.90.9-0.00.0
Bone: trabecular tissue density2.23.35.1-1.0-1.1-2.20.0-2.2-2.2-2.2-2.1-2.3-2.22.20.91.0
Water consumed over 24 hours0.20.30.7-0.9-0.8-0.5-0.8-0.4-0.4-0.4-0.4-0.4-0.40.5-0.5-0.6
Number of responses in last shaping day0.91.01.4-0.2-0.1-1.00.6-1.2-1.2-1.2-1.2-1.1-1.11.11.01.0