Hub : Genes

P4ha3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression P4ha3 0.2 0.1 5.6e-16 0.13 0.14 0.14 0.14 2.0e-14 3.7e-15 5.1e-15 1.2e-14
2 BLA gene expression P4ha3 0.09 0.07 4.6e-04 0.03 0.04 0.01 0.03 7.1e-03 2.2e-03 7.5e-02 9.1e-03
3 PL mRNA stability P4ha3 0.45 0.18 0.0e+00 0.28 0.3 0.3 0.29 4.2e-31 6.3e-34 1.7e-33 4.5e-32
4 IL mRNA stability P4ha3 0.26 0.15 1.6e-04 0.09 0.06 0.01 0.04 3.8e-03 1.5e-02 1.4e-01 4.5e-02
5 OFC mRNA stability P4ha3 0.42 0.18 7.5e-09 0.3 0.29 0.29 0.28 5.6e-08 1.1e-07 1.1e-07 2.5e-07
6 BLA mRNA stability P4ha3 0.28 0.14 5.9e-13 0.2 0.21 0.21 0.21 1.0e-10 1.2e-11 1.5e-11 1.3e-11
7 pVTA gene expression P4ha3 0.29 0.13 9.5e-09 0.1 0.18 0.17 0.18 3.1e-05 3.3e-08 5.6e-08 3.8e-08
8 Brain mRNA stability P4ha3 0.25 0.13 0.0e+00 0.25 0.27 0.26 0.26 1.5e-23 9.3e-25 2.1e-24 8.9e-24
9 Brain gene expression P4ha3 0.22 0.13 1.5e-11 0.12 0.12 0.12 0.12 2.5e-11 2.0e-11 5.8e-11 2.3e-11
10 NAcc gene expression P4ha3 0.19 0.1 2.0e-14 0.12 0.11 0.11 0.11 9.3e-14 8.3e-13 1.1e-12 9.9e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.30.6-0.60.20.2-0.4-0.40.3-0.80.3-0.80.8
Area under the delay curve0.10.10.3-0.0-0.4-0.50.30.3-0.40.1-0.40.2-0.1
BMI with tail0.10.30.50.1-0.4-0.50.70.7-0.50.4-0.50.5-0.3
BMI without tail1.53.16.61.7-0.8-1.21.21.2-1.32.4-1.42.6-2.6
Body weight1.04.48.31.8-1.2-1.71.71.7-1.82.7-1.82.9-2.8
Weight adjusted by age0.60.71.81.1-0.1-0.20.30.3-0.31.3-0.41.3-1.3
Bone surface0.40.81.41.21.00.9-0.9-0.90.90.80.80.7-0.5
Bone volume0.30.50.70.80.80.8-0.8-0.80.70.50.70.4-0.3
Breakpoint value in progressive ratio session0.30.41.0-0.80.00.1-0.1-0.10.2-1.00.2-1.01.0
Number of licking bursts4.14.87.8-2.0-2.8-2.72.72.7-2.6-0.9-2.5-0.60.1
Context. condit. distance diff. score2.22.64.31.32.12.0-2.0-2.02.00.42.00.10.3
Locomotion velocity, session 10.50.61.4-0.80.20.4-0.4-0.40.4-1.10.5-1.11.2
Locomotion distance, session 10.91.22.10.51.31.3-1.4-1.41.3-0.11.3-0.20.5
Locomotion velocity, session 20.00.00.10.30.20.1-0.1-0.10.10.30.10.3-0.2
Locomotion distance, session 20.40.50.90.50.90.9-0.9-0.90.90.20.90.00.1
Locomotion velocity, session 31.01.11.90.31.31.3-1.4-1.41.3-0.41.3-0.50.7
Locomotion distance, session 31.82.03.20.51.71.7-1.8-1.81.7-0.41.7-0.60.9
Stereotopy head waving bouts, day 30.60.71.1-0.2-1.0-1.01.11.1-1.00.3-1.00.4-0.6
Stereotopy head waving duration, day 30.10.10.20.00.40.5-0.4-0.40.5-0.20.5-0.20.3
Locomotion velocity, session 70.20.20.5-0.7-0.2-0.10.10.1-0.1-0.7-0.0-0.70.7
Locomotion distance, session 70.10.10.2-0.3-0.5-0.50.40.4-0.4-0.1-0.4-0.1-0.0
Stereotopy head waving bouts, day 72.12.43.91.32.01.9-1.9-1.91.90.51.90.20.1
Stereotopy head waving duration, day 72.22.64.31.72.11.9-1.9-1.91.90.91.80.7-0.3
Locomotion velocity, session 80.60.71.10.81.11.0-1.0-1.01.00.31.00.20.0
Locomotion distance, session 81.82.64.31.52.12.0-1.9-1.91.90.71.90.5-0.1
Degree of sensitization distance2.62.73.80.2-1.7-1.81.91.9-1.91.1-1.91.3-1.7
Degree of sensitization stereotypy4.54.98.12.02.82.7-2.7-2.72.70.92.60.50.0
Conditioned locomotion0.10.20.4-0.50.10.2-0.2-0.20.2-0.60.2-0.70.7
Cocaine response after cond. corrected1.92.23.7-0.9-1.9-1.81.91.9-1.8-0.1-1.80.1-0.5
Cocaine response after cond. not corrected0.50.51.1-0.5-0.9-0.81.01.0-0.9-0.1-0.9-0.0-0.1
Cocaine response before conditioning2.12.54.20.82.02.0-2.0-2.02.0-0.12.0-0.40.8
Saline control response1.21.63.92.01.10.9-0.7-0.70.71.80.71.6-1.4
Bone: connectivity density0.40.60.9-0.40.60.7-0.8-0.80.8-0.80.8-0.80.9
Bone: cortical apparent density1.82.44.0-1.1-2.0-2.01.91.9-1.9-0.2-1.90.0-0.4
Bone: cortical area0.30.41.11.00.20.1-0.1-0.10.01.00.01.0-1.0
Bone: cortical porosity1.31.42.30.51.41.5-1.4-1.41.5-0.21.5-0.40.7
Bone: cortical porosity1.11.32.00.31.31.4-1.4-1.41.4-0.31.4-0.50.8
Bone: cortical thickness0.10.10.3-0.5-0.3-0.30.20.2-0.2-0.4-0.2-0.40.3
Bone: cortical thickness0.20.30.40.10.60.6-0.7-0.70.6-0.20.6-0.20.3
Bone: cortical tissue density1.72.33.8-1.1-1.9-1.91.81.8-1.9-0.3-1.9-0.0-0.3
Condit. Reinf. active minus inactive responses0.40.41.20.8-0.1-0.20.30.3-0.31.0-0.31.0-1.1
Condit. Reinf. active-inactive response ratio0.60.72.01.20.1-0.10.20.2-0.21.3-0.21.3-1.4
Condit. Reinf. active responses0.10.20.40.3-0.2-0.30.30.3-0.30.5-0.30.5-0.6
Condit. Reinf. inactive responses0.00.00.1-0.3-0.1-0.00.00.00.0-0.40.0-0.30.4
Incentive salience index mean0.30.31.00.80.0-0.10.10.1-0.10.9-0.20.9-1.0
Condit. Reinf. lever presses0.10.10.20.40.20.1-0.1-0.10.10.40.10.4-0.4
Condit. Reinf. active minus inactive responses4.35.312.73.62.21.7-1.7-1.71.53.11.52.8-2.4
Condit. Reinf. active-inactive response ratio1.11.22.31.51.21.0-1.0-1.01.01.20.91.0-0.8
Condit. Reinf. active responses5.57.719.04.42.41.8-1.8-1.81.63.91.53.6-3.1
Condit. Reinf. inactive responses3.23.910.13.21.51.1-1.0-1.00.92.90.82.8-2.5
Condit. Reinf. lever presses10.614.429.05.44.23.6-3.5-3.53.34.13.23.6-2.8
Condit. Reinf. lever reinforcers received6.28.720.74.62.72.2-2.2-2.21.93.91.83.6-3.1
Conditioned reinforcement - actives2.62.64.41.32.12.0-2.0-2.02.00.42.00.10.5
Conditioned reinforcement - inactives0.30.30.8-0.0-0.5-0.40.90.9-0.50.3-0.60.3-0.4
Conditioned locomotion3.03.66.01.02.42.3-2.4-2.42.4-0.12.4-0.40.7
Patch foraging indifference point 0 sec2.54.16.42.52.52.2-2.2-2.22.21.62.11.3-0.7
Patch foraging indifference point AUC0.70.81.50.6-0.6-0.80.60.6-0.81.0-0.81.1-1.2
Delay disc. indifference point, 0s delay0.40.51.01.00.60.5-0.5-0.50.50.90.40.8-0.8
Delay disc. indifference point, 16s delay0.10.10.2-0.4-0.1-0.1-0.1-0.10.0-0.40.0-0.40.5
Delay disc. indifference point, 2s delay0.60.61.71.20.1-0.10.10.1-0.11.3-0.11.3-1.2
Delay disc. indifference point, 24s delay0.60.61.2-1.1-0.9-0.80.60.6-0.7-0.9-0.6-0.80.7
Delay disc. indifference point, 4s delay0.80.92.31.3-0.0-0.30.20.2-0.31.5-0.41.5-1.4
Delay disc. indifference point, 8s delay0.00.00.00.1-0.1-0.1-0.1-0.1-0.00.1-0.00.10.0
Indifference point function ln k2.12.94.50.32.02.0-2.1-2.12.1-0.72.1-0.91.3
Indifference point function log k2.12.94.50.32.02.0-2.1-2.12.1-0.72.1-0.91.3
Patch foraging total patch changes 0 sec2.03.25.32.32.21.9-1.9-1.91.81.61.81.3-0.7
Patch foraging total patch changes 12 sec1.01.33.41.70.40.0-0.2-0.2-0.01.8-0.11.8-1.7
Patch foraging total patch changes 18 sec1.31.63.82.01.31.1-1.0-1.00.91.60.91.5-1.1
Patch foraging total patch changes 24 sec0.91.13.01.60.40.20.00.00.01.7-0.01.7-1.6
Patch foraging total patch changes 6 sec0.40.61.10.90.90.7-1.1-1.10.80.50.80.4-0.2
Patch foraging time to switch 0 sec2.13.26.4-2.5-2.0-1.71.61.6-1.6-1.9-1.5-1.71.4
Patch foraging water rate 0 sec2.03.35.02.22.22.0-2.0-2.02.01.31.91.1-0.7
Patch foraging water rate 12 sec1.72.64.51.52.12.1-1.9-1.92.00.71.90.4-0.2
Patch foraging water rate 18 sec0.81.12.31.51.11.0-0.8-0.80.81.20.81.1-1.2
Patch foraging water rate 24 sec1.72.44.20.51.81.8-2.1-2.11.9-0.41.9-0.60.8
Patch foraging water rate 6 sec1.11.62.70.91.61.6-1.6-1.61.50.21.50.00.1
Seeking ratio, delayed vs. immediate footshock0.80.92.3-1.5-0.6-0.20.70.7-0.3-1.4-0.3-1.41.2
Distance traveled before self-admin1.01.12.4-1.1-1.4-1.51.01.0-1.3-0.6-1.2-0.40.3
Distance traveled after self-admin1.01.12.5-1.10.30.5-0.8-0.80.6-1.50.7-1.61.6
Extensor digitorum longus weight0.41.82.30.4-1.3-1.41.51.5-1.51.1-1.51.3-1.5
Bone: elastic displacement1.41.64.0-2.0-1.0-0.80.70.7-0.7-1.8-0.6-1.71.5
Bone: elastic work1.31.74.4-2.1-0.8-0.50.50.5-0.4-2.0-0.3-1.91.8
Bone: endosteal estimation1.02.15.62.30.50.3-0.0-0.00.12.4-0.02.3-2.2
Bone: endosteal perimeter1.12.35.92.40.90.6-0.5-0.50.42.40.32.3-2.1
Epididymis fat weight1.43.24.70.1-1.9-2.12.12.1-2.21.2-2.21.4-1.5
Delta time in closed arm before/after self-admin4.14.06.1-0.1-2.3-2.52.32.3-2.51.1-2.51.4-1.6
Delta time in open arm before/after self-admin2.42.33.92.01.91.8-1.5-1.51.61.41.51.1-0.9
Diff in mean of infusions in LGA sessions2.42.64.5-1.7-2.1-2.01.81.8-1.9-0.9-1.9-0.60.1
Delay discount exponential model param0.10.10.30.10.50.6-0.4-0.40.5-0.10.5-0.20.1
Extinction: sum of active levers before priming0.10.10.2-0.2-0.4-0.30.40.4-0.3-0.1-0.3-0.00.0
Active lever presses in extinction session 64.24.17.40.42.32.2-2.7-2.72.4-0.82.5-1.01.5
Bone: final force0.00.00.0-0.1-0.2-0.20.20.2-0.20.0-0.20.1-0.1
Bone: final moment0.00.00.10.20.0-0.00.00.0-0.00.3-0.10.3-0.3
Food consumed during 24 hour testing period3.13.76.11.82.52.4-2.4-2.42.30.82.30.4-0.0
Glucose0.10.10.2-0.10.30.3-0.4-0.40.4-0.30.4-0.30.4
Heart weight0.91.21.91.31.41.3-1.2-1.21.20.81.20.6-0.4
Delay discount hyperbolic model param0.20.20.3-0.20.40.6-0.4-0.40.5-0.40.5-0.50.4
Intermittent access intake day 1-15 change0.60.51.10.70.90.7-1.1-1.10.80.40.80.3-0.2
Intermittent access intake escalation0.70.71.50.71.00.8-1.2-1.20.90.30.90.2-0.1
Intermittent access intake escalation 20.20.20.70.60.0-0.3-0.3-0.3-0.10.7-0.10.7-0.8
Intermitt. access day 1 inactive lever presses0.40.41.0-0.2-0.7-0.61.01.0-0.80.2-0.80.2-0.4
Intermitt. access day 15 inactive lever presses0.30.30.70.10.70.8-0.5-0.50.7-0.20.7-0.40.6
Intermitt. access escalation Index0.30.20.50.50.50.4-0.7-0.70.50.30.50.3-0.1
Intermittent access day 1 total infusions0.80.91.81.31.21.2-0.5-0.51.01.00.90.8-0.5
Intermittent access day 15 total infusions1.41.52.51.31.61.5-1.4-1.41.40.71.40.5-0.1
Intermittent access terminal intake (last 3 days)1.01.11.81.31.31.2-1.1-1.11.10.91.10.7-0.4
Intermittent access total infusions0.80.81.61.31.11.2-0.6-0.61.00.90.90.7-0.5
Intermittent access day 1 locomotion0.20.20.50.10.60.7-0.4-0.40.6-0.20.6-0.30.4
Intermittent access day 15 total locomotion1.21.32.20.91.41.3-1.5-1.51.30.41.30.20.1
Intermittent access total locomotion0.50.61.00.81.01.0-0.7-0.70.90.50.90.3-0.1
Intermittent access standard deviation0.10.10.30.4-0.1-0.20.00.0-0.20.5-0.20.5-0.4
Left kidney weight1.02.77.32.3-0.1-0.50.40.4-0.62.7-0.62.7-2.4
Right kidney weight0.61.84.71.7-0.2-0.60.40.4-0.62.1-0.62.2-2.0
Cocaine induced anxiety1.41.62.7-1.7-1.5-1.41.21.2-1.3-1.2-1.2-1.00.8
Post-drug Anxiety0.91.01.7-0.8-1.3-1.31.21.2-1.3-0.2-1.2-0.1-0.3
Baseline Anxiety0.70.81.81.30.80.7-0.5-0.50.51.10.51.1-1.1
Tail length3.19.224.23.7-0.5-1.21.31.3-1.54.7-1.64.8-4.9
Length with tail1.86.715.92.7-1.0-1.51.71.7-1.83.7-1.93.8-4.0
Length without tail0.10.20.4-0.6-0.5-0.40.50.5-0.4-0.5-0.4-0.40.4
Times rat made contact with spout0.81.01.40.0-1.1-1.21.11.1-1.20.6-1.20.7-0.9
Lifetime Intake1.01.12.01.41.41.4-0.7-0.71.21.01.10.8-0.5
Liver weight, left1.62.53.70.0-1.7-1.81.91.9-1.90.9-1.91.2-1.4
Liver weight, right3.45.78.4-0.0-2.6-2.82.92.9-2.91.3-2.91.7-2.2
Locomotor activity0.40.71.40.71.00.7-1.2-1.20.90.30.90.20.2
Locomotor testing distance1.11.83.71.91.41.1-1.3-1.31.11.51.11.3-0.9
Locomotor testing rearing0.60.92.71.40.0-0.30.00.0-0.31.6-0.31.6-1.3
Locomotion in novel chamber1.41.74.00.11.31.1-2.0-2.01.4-0.71.5-0.81.0
Locomotion in novel chamber post-restriction2.12.54.11.22.02.0-2.0-2.02.00.31.90.00.1
Fecal boli incidents, locomotor time 11.21.32.40.51.41.4-1.5-1.51.4-0.21.4-0.40.6
Change in fecal boli incidents, locomotor task0.80.81.3-0.9-1.1-1.11.11.1-1.1-0.4-1.0-0.3-0.0
Time >=10cm from walls, locomotor time 11.81.83.01.01.71.7-1.7-1.71.60.31.60.10.2
Bouts of movement, locomotor time 10.20.30.50.30.60.6-0.7-0.70.60.10.6-0.00.1
Total resting periods, locomotor time 10.50.50.8-0.10.80.8-0.9-0.90.9-0.50.9-0.60.7
Rest time, locomotor task time 10.30.40.7-0.50.40.6-0.4-0.40.5-0.80.5-0.80.8
Distance moved, locomotor task time 10.80.81.70.8-0.5-0.80.60.6-0.81.2-0.81.3-1.3
Vertical activity count, locomotor time 10.50.51.20.9-0.1-0.20.40.4-0.31.1-0.31.1-1.0
Time >=10cm from walls, locomotor time 20.91.02.01.41.11.1-0.8-0.80.91.10.90.9-0.7
Bouts of movement, locomotor time 20.70.71.80.9-0.3-0.60.40.4-0.61.3-0.61.3-1.3
Total resting periods, locomotor time 20.60.61.20.5-0.6-0.80.70.7-0.81.0-0.81.0-1.1
Rest time, locomotor task time 21.92.24.4-2.1-1.6-1.31.51.5-1.3-1.6-1.3-1.41.1
Distance moved, locomotor task time 22.02.35.42.31.51.2-1.2-1.21.11.91.01.8-1.5
Vertical activity count, locomotor time 20.91.02.71.60.50.3-0.1-0.10.21.60.21.6-1.4
Light reinforcement 11.63.04.5-2.1-2.1-1.91.91.9-1.8-1.4-1.8-1.10.8
Light reinforcement 20.30.41.1-1.0-0.10.0-0.0-0.00.1-1.10.1-1.11.0
Bone: marrow area0.91.95.12.10.40.10.10.1-0.12.3-0.22.2-2.1
Bone: maximum diameter1.01.94.92.21.10.8-0.6-0.60.72.00.61.9-1.7
Bone: maximum force0.00.00.10.20.10.0-0.0-0.00.00.20.00.2-0.2
Bone: maximum moment0.10.10.20.50.30.2-0.2-0.20.20.40.20.4-0.3
Mean time between licks in bursts3.54.912.83.51.00.6-0.2-0.20.33.60.23.5-3.2
Mean num. licks in bursts3.13.75.92.02.42.3-2.3-2.32.21.12.20.8-0.3
Cd content in liver0.91.01.6-0.3-1.2-1.21.21.2-1.30.3-1.30.5-0.7
Co content in liver1.01.23.11.80.60.4-0.3-0.30.31.70.21.7-1.5
Cu content in liver0.81.02.71.50.2-0.10.20.2-0.21.6-0.21.6-1.6
Fe content in liver0.10.10.1-0.0-0.3-0.30.30.3-0.30.2-0.30.2-0.2
K content in liver0.40.40.6-0.1-0.7-0.80.80.8-0.80.3-0.80.4-0.5
Mg content in liver0.10.10.30.50.20.2-0.1-0.10.10.50.10.5-0.4
Mn content in liver1.21.33.4-1.8-0.5-0.20.10.1-0.1-1.9-0.0-1.81.7
Na content in liver0.20.20.40.40.60.7-0.5-0.50.60.10.60.00.1
Rb content in liver0.50.61.31.20.70.6-0.6-0.60.61.00.50.9-0.7
Se content in liver2.02.45.2-2.3-1.7-1.41.41.4-1.3-1.8-1.3-1.61.2
Sr content in liver0.30.30.5-0.30.40.5-0.5-0.50.5-0.60.6-0.70.7
Zn content in liver2.93.25.92.42.11.9-1.7-1.71.81.71.71.5-1.0
Bone: minimum diameter1.22.35.41.6-0.6-0.91.01.0-1.02.1-1.12.2-2.3
Time in familiar zone, hab. session 10.20.20.40.3-0.3-0.30.40.4-0.40.5-0.40.5-0.6
Time in novel zone, hab. session 10.20.20.3-0.5-0.5-0.50.50.5-0.5-0.3-0.4-0.20.2
Total zone transitions, hab. session 10.40.61.0-0.40.60.7-0.7-0.70.7-0.80.8-0.91.0
Total locomotion distance, hab. session 11.62.33.3-0.1-1.7-1.71.81.8-1.80.8-1.81.0-1.4
Locomotion velocity, hab. session 10.91.31.90.0-1.2-1.31.41.4-1.40.7-1.40.8-1.1
Time in familiar zone, hab. session 20.91.02.21.51.00.8-0.7-0.70.71.20.71.1-1.0
Time in novel zone, hab. session 20.30.30.8-0.9-0.3-0.20.10.1-0.1-0.9-0.1-0.80.8
Total zone transitions, hab. session 21.51.93.00.81.71.7-1.7-1.71.70.01.7-0.20.5
Total locomotion distance, hab. session 21.01.32.50.8-0.8-0.91.11.1-1.11.3-1.11.4-1.6
Locomotion velocity, hab. session 21.31.83.00.7-1.0-1.21.31.3-1.31.4-1.41.5-1.7
Novel to familiar place preference ratio0.10.10.10.20.30.3-0.3-0.30.30.00.3-0.00.1
Novelty place preference0.10.10.10.20.30.3-0.3-0.30.30.00.3-0.00.1
Time in novel zone, NPP test0.20.20.30.30.50.5-0.5-0.50.50.10.50.00.0
Total zone transitions, NPP test0.40.61.00.10.90.9-1.0-1.00.9-0.41.0-0.50.6
Total locomotion distance, NPP test1.11.52.10.1-1.3-1.41.41.4-1.40.8-1.51.0-1.2
Locomotion velocity, NPP test1.31.82.8-0.2-1.6-1.61.61.6-1.70.6-1.70.8-1.1
Intraocular pressure0.60.81.3-0.10.90.9-1.2-1.21.0-0.51.0-0.60.9
Delta distance traveled before/after self-admin1.71.94.00.71.82.0-1.5-1.51.8-0.01.7-0.30.4
Delta ambulatory time before/after self-admin2.22.45.00.52.02.2-1.8-1.82.0-0.32.0-0.60.8
Parametrial fat weight1.42.64.4-0.4-1.9-1.92.12.1-2.00.5-2.00.7-1.0
Pavlov. Cond. lever latency0.70.91.9-1.4-1.1-0.90.90.9-0.9-1.1-0.8-0.90.7
Pavlov. Cond. magazine entry latency1.72.24.92.21.61.4-1.2-1.21.31.71.21.5-1.2
Pavlov. Cond. change in total contacts0.90.92.11.51.00.9-0.8-0.80.81.20.71.1-0.8
Pavlov. Cond. index score1.82.25.02.21.61.3-1.2-1.21.21.81.11.6-1.3
Pavlov. Cond. latency score1.72.24.72.21.61.3-1.2-1.21.21.71.21.5-1.2
Pavlov. Cond. lever contacts0.80.92.31.50.80.6-0.6-0.60.61.30.51.2-1.0
Pavlov. Cond. magazine entry number2.12.65.0-2.2-1.9-1.61.51.5-1.5-1.7-1.5-1.41.0
Pavlov. Cond. intertrial magazine entries0.60.71.6-1.3-0.9-0.70.70.7-0.7-1.0-0.6-0.90.6
Pavlov. Cond. lever-magazine prob. diff.1.41.83.92.01.41.2-1.1-1.11.11.61.01.4-1.1
Pavlov. Cond. response bias0.70.92.21.50.90.7-0.6-0.60.61.30.61.2-0.9
Pavlov. Cond. lever latency11.014.827.6-5.3-4.4-3.83.83.8-3.6-3.9-3.5-3.32.5
Pavlov. Cond. magazine entry latency3.03.45.42.02.32.2-2.2-2.22.11.12.10.8-0.4
Pavlov. Cond. change in total contacts8.712.020.04.54.13.7-3.7-3.73.53.13.42.6-1.8
Pavlov. Cond. index score8.711.219.74.43.93.5-3.4-3.43.33.23.22.7-1.9
Pavlov. Cond. latency score7.99.816.84.13.73.3-3.3-3.33.12.93.02.4-1.7
Pavlov. Cond. lever contacts11.415.629.05.44.53.9-3.9-3.93.74.03.63.4-2.6
Pavlov. Cond. magazine entry number5.26.410.0-2.8-3.2-2.93.03.0-2.8-1.6-2.8-1.20.6
Pavlov. Cond. intertrial magazine entries1.11.42.40.7-0.8-1.01.21.2-1.11.3-1.11.4-1.6
Pavlov. Cond. lever-magazine prob. diff.8.110.318.94.43.73.3-3.2-3.23.03.22.92.7-2.0
Pavlov. Cond. response bias11.715.928.15.34.74.1-4.1-4.13.93.83.83.2-2.3
Time in closed arm before self-admin4.24.87.40.32.52.6-2.7-2.72.7-0.92.7-1.31.7
Time in closed arm after self-admin0.70.71.9-1.3-0.2-0.1-0.2-0.20.0-1.40.1-1.31.4
Time in open arm before self-admin3.74.07.3-1.8-2.7-2.72.22.2-2.5-0.8-2.4-0.40.1
Time in open arm after self-admin0.91.02.21.0-0.4-0.60.60.6-0.71.4-0.71.5-1.5
Bone: periosteal estimation0.81.74.52.00.60.3-0.1-0.10.12.10.12.1-1.9
Bone: periosteal perimeter0.91.43.61.90.80.5-0.5-0.50.41.80.31.7-1.6
Bone: post-yield work0.10.10.20.50.50.4-0.4-0.40.40.30.40.2-0.1
Progressive ratio test 1 active lever presses0.10.10.2-0.2-0.10.00.40.4-0.1-0.2-0.1-0.20.2
Progressive ratio test 1 breakpoint0.10.10.3-0.1-0.2-0.10.50.5-0.30.1-0.30.0-0.0
Progressive ratio test 1 inactive lever presses0.30.30.70.80.60.90.30.30.50.70.40.5-0.3
Progressive ratio test 2 active lever presses0.50.61.41.20.70.5-0.5-0.50.51.00.41.0-0.7
Progressive ratio test 2 breakpoint0.50.61.61.30.70.5-0.5-0.50.51.10.41.0-0.8
Progressive ratio test 2 inactive lever presses0.80.91.90.91.31.4-0.8-0.81.20.41.10.20.2
Incentive Sensitization - Responses1.31.33.21.80.90.6-0.9-0.90.61.60.61.5-1.2
Incentive Sensitization - Breakpoint1.11.22.71.61.00.6-1.0-1.00.71.40.71.3-1.0
Sum of active levers in priming session hrs 5-60.30.30.6-0.7-0.1-0.1-0.4-0.40.1-0.80.2-0.80.8
Progressive ratio0.20.20.3-0.20.40.5-0.5-0.50.5-0.50.5-0.50.5
Food seeking constrained by brief footshock0.70.92.31.40.2-0.1-0.1-0.1-0.11.5-0.11.5-1.5
Seeking ratio, punishment vs. effort1.11.33.41.5-0.2-0.50.50.5-0.61.8-0.61.8-1.8
Retroperitoneal fat weight5.919.330.6-0.6-5.0-5.25.55.5-5.32.0-5.42.6-3.4
Reaction time number correct1.11.52.0-0.71.01.0-1.4-1.41.2-1.31.3-1.41.3
Reaction time mean minus median0.40.51.41.20.60.5-0.3-0.30.41.10.31.0-0.9
Reaction time mean minus median AUC0.70.91.41.11.21.1-1.1-1.11.10.71.00.5-0.4
Reaction time num false alarms1.82.44.0-1.3-2.0-2.01.91.9-1.9-0.5-1.9-0.2-0.0
Reaction time num false alarms AUC0.81.11.8-1.1-1.4-1.31.31.3-1.2-0.6-1.2-0.40.3
Reaction time trials correct on left1.11.52.0-0.71.01.0-1.4-1.41.2-1.31.3-1.41.3
Reaction time trials on left1.11.52.1-0.70.91.0-1.4-1.41.2-1.41.3-1.41.4
Reaction time mean0.81.22.1-0.6-1.3-1.31.51.5-1.3-0.0-1.30.2-0.4
Reaction time mean AUC0.91.22.2-0.9-1.3-1.21.51.5-1.2-0.4-1.2-0.2-0.0
Median of all reaction times1.21.62.8-1.1-1.6-1.51.71.7-1.4-0.5-1.4-0.30.0
Reaction time omissions0.40.50.8-0.4-0.9-0.90.90.9-0.90.0-0.90.1-0.1
Reaction time false alarm rate1.52.23.7-0.8-1.8-1.81.91.9-1.80.1-1.80.3-0.4
Reaction time premature initiation rate1.82.46.42.1-0.0-0.30.50.5-0.52.5-0.62.5-2.4
Reaction time premature initiations0.71.02.51.60.70.5-0.4-0.40.41.50.31.4-1.4
Std. dev. reaction times0.81.12.41.0-0.5-0.70.80.8-0.81.4-0.81.5-1.5
Reaction time trials completed1.11.52.1-0.70.91.0-1.4-1.41.2-1.41.3-1.41.4
Reaction time trials AUC0.81.11.6-0.60.80.9-1.3-1.31.0-1.11.1-1.21.1
Run reversals in cocaine runway, females4.84.66.50.7-1.9-2.02.52.5-2.31.9-2.42.1-2.5
Run reversals in cocaine runway, males0.10.10.2-0.3-0.10.10.20.20.0-0.30.0-0.30.4
Latency to leave start box in cocaine runway2.83.05.4-1.2-2.2-2.02.32.3-2.1-0.2-2.10.1-0.4
Latency to leave start box in cocaine runway, F3.33.66.3-0.7-2.3-2.22.52.5-2.30.4-2.40.7-1.0
Latency to leave start box in cocaine runway, M0.30.30.9-0.9-0.2-0.00.00.00.0-0.90.0-0.90.8
Std. dev. time between licks in bursts2.02.46.02.0-0.2-0.50.60.6-0.72.4-0.72.4-2.4
Total sessions with >9 infusions2.22.55.01.62.12.2-1.5-1.51.90.81.90.5-0.1
Short access day 1 total inactive lever presses0.10.10.2-0.20.00.40.40.40.1-0.20.0-0.30.2
Short access day 10 total inactive lever presses0.10.10.2-0.4-0.2-0.2-0.1-0.1-0.1-0.4-0.0-0.40.3
Short access day 1 total infusions1.61.73.51.91.51.5-0.9-0.91.31.41.21.2-0.9
Short access day 10 total infusions0.91.02.61.60.90.8-0.4-0.40.61.40.61.3-1.0
Short access total infusions0.70.81.91.41.01.1-0.2-0.20.81.10.71.0-0.8
Short access day 1 locomotion2.22.44.50.92.02.1-1.8-1.82.0-0.02.0-0.30.6
Short access day 10 total locomotion0.20.20.50.70.3-0.1-0.5-0.50.10.70.20.7-0.6
Short access total locomotion0.10.10.20.40.40.4-0.3-0.30.40.20.40.2-0.1
One hour access (0.3 mA shock)1.41.63.01.71.51.3-1.2-1.21.21.31.21.1-0.8
Compulsive drug intake0.50.51.1-0.60.40.4-0.6-0.60.5-0.90.6-0.91.0
One hour access (shock baseline)1.11.22.81.71.10.9-0.9-0.90.81.40.81.3-1.1
Social response proportion0.60.61.0-0.1-0.9-0.90.90.9-1.00.4-1.00.5-0.9
Social responses1.31.72.40.3-1.3-1.31.51.5-1.51.0-1.51.2-1.5
Social time1.62.14.8-2.2-1.4-1.01.21.2-1.0-1.8-1.0-1.71.3
Soleus weight1.33.95.90.9-1.7-2.02.02.0-2.12.0-2.12.2-2.4
Bone: stiffness0.50.71.1-0.0-0.9-1.01.01.0-1.00.5-1.00.6-0.8
Tibialis anterior weight0.20.61.40.9-0.3-0.40.50.5-0.51.1-0.51.2-1.2
Time to tail flick, vehicle, before self-admin0.10.10.2-0.40.00.0-0.5-0.50.1-0.40.2-0.40.4
Time to tail flick, vehicle, after self-admin2.42.55.11.32.12.3-1.7-1.72.00.51.90.20.2
Time to tail flick, test, before self-admin0.30.30.90.80.10.10.30.3-0.00.9-0.10.9-0.9
Time to tail flick, test, after self-admin1.01.13.01.1-0.3-0.50.40.4-0.71.5-0.71.6-1.7
Delta time to tail flick, vehicle, before/after SA1.41.43.41.21.61.8-0.9-0.91.50.61.40.4-0.1
Delta time to tail flick, test, before/after SA0.20.20.4-0.3-0.6-0.60.40.4-0.6-0.1-0.60.0-0.2
Tibia length1.85.08.11.42.82.8-2.8-2.82.80.12.8-0.20.8
Ambulatory time before self-admin0.90.91.6-1.2-1.2-1.30.80.8-1.0-0.9-0.9-0.70.6
Ambulatory time after self-admin1.71.83.7-1.10.81.1-1.2-1.21.1-1.61.2-1.81.9
Bone: tissue strength1.41.33.0-1.10.60.8-0.9-0.90.9-1.60.9-1.61.7
Total heroin consumption0.40.50.80.20.90.9-0.8-0.80.9-0.20.9-0.30.4
Bone: trabecular number0.60.92.4-1.5-0.5-0.30.10.1-0.2-1.6-0.1-1.51.4
Bone: trabecular spacing0.60.71.11.01.11.0-0.9-0.90.90.60.90.5-0.2
Bone: trabecular thickness0.20.30.4-0.4-0.7-0.70.60.6-0.6-0.1-0.6-0.0-0.1
Bone: trabecular tissue density2.53.55.4-0.3-2.2-2.32.32.3-2.30.8-2.31.1-1.5
Water consumed over 24 hours0.30.41.1-1.0-0.6-0.50.30.3-0.4-0.9-0.4-0.80.7
Number of responses in last shaping day0.30.30.70.70.0-0.10.10.1-0.10.9-0.20.9-0.7